SIMILAR PATTERNS OF AMINO ACIDS FOR 4XO7_A_ASDA402_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amk TRIOSE PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00121
(TIM) 		4 ILE A 150
TRP A 193
LEU A 189
LEU A 190
 None
 1.01A 4xo7A-1amkA:
8.3		 4xo7A-1amkA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aog TRYPANOTHIONE
REDUCTASE

(Trypanosoma
cruzi) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A  34
ILE A  35
LEU A 297
LEU A 130
 None
FAD  A 492 ( 4.6A)
None
None
 0.97A 4xo7A-1aogA:
undetectable		 4xo7A-1aogA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1atg PERIPLASMIC
MOLYBDATE-BINDING
PROTEIN

(Azotobacter
vinelandii) 		PF13531
(SBP_bac_11) 		4 VAL A 142
ILE A 141
TRP A 105
LEU A  85
 None
 1.01A 4xo7A-1atgA:
undetectable		 4xo7A-1atgA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dr6 DIHYDROFOLATE
REDUCTASE

(Gallus gallus) 		PF00186
(DHFR_1) 		4 VAL A 120
ILE A 114
LEU A 105
LEU A 100
 NAP  A 191 (-4.3A)
None
None
None
 0.99A 4xo7A-1dr6A:
undetectable		 4xo7A-1dr6A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee0 2-PYRONE SYNTHASE

(Gerbera hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 VAL A 347
ILE A 350
LEU A 324
LEU A 329
 None
 0.92A 4xo7A-1ee0A:
undetectable		 4xo7A-1ee0A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f5a POLY(A) POLYMERASE

(Bos taurus) 		PF01909
(NTP_transf_2)
PF04926
(PAP_RNA-bind)
PF04928
(PAP_central) 		4 VAL A  72
ILE A  76
LEU A 189
LEU A 173
 None
 1.01A 4xo7A-1f5aA:
undetectable		 4xo7A-1f5aA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		4 VAL A  69
ILE A  70
LEU A  95
LEU A  97
 None
 0.85A 4xo7A-1g0dA:
undetectable		 4xo7A-1g0dA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 VAL A 496
ILE A 499
LEU A 528
LEU A 526
 None
 1.03A 4xo7A-1g8kA:
undetectable		 4xo7A-1g8kA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN

(Escherichia
virus T4) 		PF13597
(NRDD) 		5 TYR A 507
VAL A 235
ILE A 270
HIS A 477
LEU A 531
 None
 1.41A 4xo7A-1h79A:
2.7		 4xo7A-1h79A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i51 CASPASE-7 SUBUNIT
P20

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 VAL A 108
ILE A 109
LEU A 162
LEU A 123
 None
 0.91A 4xo7A-1i51A:
undetectable		 4xo7A-1i51A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j0n XANTHAN LYASE

(Bacillus sp.
GL1) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 VAL A 209
ILE A 210
LEU A 105
LEU A 164
 None
 0.80A 4xo7A-1j0nA:
undetectable		 4xo7A-1j0nA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeq KU70

(Homo sapiens) 		PF02037
(SAP)
PF02735
(Ku)
PF03730
(Ku_C)
PF03731
(Ku_N) 		4 VAL A 268
ILE A 269
LEU A 434
LEU A 413
 None
 0.85A 4xo7A-1jeqA:
undetectable		 4xo7A-1jeqA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jm1 RIESKE IRON-SULFUR
PROTEIN SOXF

(Sulfolobus
acidocaldarius) 		PF00355
(Rieske) 		4 VAL A 197
ILE A 196
LEU A  98
LEU A  95
 None
 0.95A 4xo7A-1jm1A:
undetectable		 4xo7A-1jm1A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k86 CASPASE-7

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 VAL A 108
ILE A 109
LEU A 162
LEU A 123
 None
 0.89A 4xo7A-1k86A:
undetectable		 4xo7A-1k86A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kbz DTDP-GLUCOSE
OXIDOREDUCTASE

(Salmonella
enterica) 		PF04321
(RmlD_sub_bind) 		4 VAL A  85
ILE A  88
LEU A  16
LEU A   5
 None
 1.01A 4xo7A-1kbzA:
undetectable		 4xo7A-1kbzA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION

(Bacillus
subtilis) 		PF01256
(Carb_kinase) 		4 VAL A 144
ILE A 145
LEU A  32
LEU A 223
 None
 1.02A 4xo7A-1kyhA:
undetectable		 4xo7A-1kyhA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mox EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		4 VAL A 417
ILE A 439
LEU A 399
LEU A 426
 None
 1.02A 4xo7A-1moxA:
undetectable		 4xo7A-1moxA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 TYR A 827
VAL A 863
ILE A 866
LEU A1184
 None
 1.00A 4xo7A-1ofeA:
4.6		 4xo7A-1ofeA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi7 SUCCINYL-COA
SYNTHETASE ALPHA
CHAIN

(Thermus
thermophilus) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding) 		4 VAL A 108
ILE A 111
LEU A   3
LEU A  91
 None
 0.86A 4xo7A-1oi7A:
undetectable		 4xo7A-1oi7A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC

(Escherichia
coli) 		PF05138
(PaaA_PaaC) 		4 VAL A  84
ILE A 101
LEU A 112
LEU A 108
 None
 0.99A 4xo7A-1otkA:
undetectable		 4xo7A-1otkA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poj ISOASPARTYL
DIPEPTIDASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		4 VAL A 152
ILE A 155
LEU A  71
LEU A 116
 None
 0.98A 4xo7A-1pojA:
8.1		 4xo7A-1pojA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8c HYPOTHETICAL PROTEIN
MG027

(Mycoplasma
genitalium) 		PF09185
(DUF1948) 		4 VAL A  22
ILE A  25
LEU A 147
LEU A 110
 None
 1.01A 4xo7A-1q8cA:
undetectable		 4xo7A-1q8cA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)

(Escherichia
coli) 		PF01464
(SLT)
PF14718
(SLT_L) 		4 ILE A 570
TRP A 324
LEU A 308
LEU A 304
 None
 0.97A 4xo7A-1qsaA:
undetectable		 4xo7A-1qsaA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tua HYPOTHETICAL PROTEIN
APE0754

(Aeropyrum
pernix) 		PF00013
(KH_1) 		4 VAL A  24
ILE A  28
LEU A  88
LEU A  81
 None
 1.01A 4xo7A-1tuaA:
undetectable		 4xo7A-1tuaA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1typ TRYPANOTHIONE
REDUCTASE

(Crithidia
fasciculata) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A  33
ILE A  34
LEU A 296
LEU A 129
 None
FAD  A 493 ( 4.8A)
None
None
 1.03A 4xo7A-1typA:
undetectable		 4xo7A-1typA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE

(Aquifex
aeolicus) 		PF02446
(Glyco_hydro_77) 		4 VAL A 356
ILE A 357
LEU A 478
LEU A 426
 None
 1.02A 4xo7A-1tz7A:
8.1		 4xo7A-1tz7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukw ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 TYR A 115
ILE A 125
LEU A  76
LEU A  82
 None
 1.01A 4xo7A-1ukwA:
undetectable		 4xo7A-1ukwA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		4 VAL A 143
ILE A 144
LEU A 157
LEU A 184
 None
 0.89A 4xo7A-1urtA:
undetectable		 4xo7A-1urtA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlu GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomyces
cerevisiae) 		PF00171
(Aldedh) 		4 VAL A 128
ILE A 132
LEU A 192
LEU A 119
 None
 0.98A 4xo7A-1vluA:
undetectable		 4xo7A-1vluA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9c CRM1 PROTEIN

(Homo sapiens) 		PF08767
(CRM1_C) 		4 VAL A 953
ILE A 958
LEU A 897
LEU A 901
 None
 1.00A 4xo7A-1w9cA:
undetectable		 4xo7A-1w9cA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		4 VAL B 337
ILE B 338
LEU B 388
LEU B 384
 None
 0.96A 4xo7A-1wa5B:
undetectable		 4xo7A-1wa5B:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00291
(PALP) 		4 VAL B 196
ILE B 195
LEU B  15
LEU B  19
 None
 0.73A 4xo7A-1wdwB:
undetectable		 4xo7A-1wdwB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ww6 GALECTIN

(Agrocybe
cylindracea) 		PF00337
(Gal-bind_lectin) 		4 VAL A 152
ILE A  11
LEU A  61
LEU A  52
 None
 0.96A 4xo7A-1ww6A:
undetectable		 4xo7A-1ww6A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xeu INTERNALIN C

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		4 VAL A 178
ILE A 177
LEU A 145
LEU A 167
 None
 0.98A 4xo7A-1xeuA:
undetectable		 4xo7A-1xeuA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		4 ILE A 222
HIS A 192
LEU A 238
LEU A 243
 None
 1.00A 4xo7A-1xjeA:
2.9		 4xo7A-1xjeA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xm7 HYPOTHETICAL PROTEIN
AQ_1665

(Aquifex
aeolicus) 		PF12850
(Metallophos_2) 		5 VAL A 169
ILE A   5
TRP A  65
LEU A  86
LEU A  74
 None
 1.36A 4xo7A-1xm7A:
undetectable		 4xo7A-1xm7A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y0u ARSENICAL RESISTANCE
OPERON REPRESSOR,
PUTATIVE

(Archaeoglobus
fulgidus) 		PF12840
(HTH_20) 		4 VAL A  80
ILE A  71
LEU A  53
LEU A  58
 None
 0.90A 4xo7A-1y0uA:
undetectable		 4xo7A-1y0uA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zg4 BETA-LACTAMASE TEM

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		4 VAL A  80
ILE A 142
LEU A 169
LEU A 162
 None
 0.80A 4xo7A-1zg4A:
undetectable		 4xo7A-1zg4A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amx ADENOSINE DEAMINASE

(Plasmodium
yoelii) 		PF00962
(A_deaminase) 		4 VAL A 280
ILE A 285
LEU A 219
LEU A 259
 None
 1.02A 4xo7A-2amxA:
5.4		 4xo7A-2amxA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2apo PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE B

(Methanocaldococcus
jannaschii) 		PF01472
(PUA)
PF01509
(TruB_N)
PF08068
(DKCLD)
PF16198
(TruB_C_2) 		4 VAL A 258
ILE A 261
LEU A 245
LEU A 286
 None
 0.89A 4xo7A-2apoA:
undetectable		 4xo7A-2apoA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8n GLYCERATE KINASE,
PUTATIVE

(Thermotoga
maritima) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		4 VAL A 177
HIS A 246
LEU A  35
LEU A  37
 None
 1.02A 4xo7A-2b8nA:
undetectable		 4xo7A-2b8nA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfu COWPEA MOSAIC VIRUS,
LARGE (L) SUBUNIT

(Cowpea mosaic
virus) 		PF02247
(Como_LCP) 		4 VAL L 104
TRP L 115
LEU L  32
LEU L  42
 None
 0.94A 4xo7A-2bfuL:
undetectable		 4xo7A-2bfuL:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cc1 BETA-LACTAMASE

(Mycolicibacterium
fortuitum) 		PF13354
(Beta-lactamase2) 		4 VAL A  80
ILE A 142
LEU A 169
LEU A 162
 None
 0.99A 4xo7A-2cc1A:
undetectable		 4xo7A-2cc1A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjw GTP-BINDING PROTEIN
GEM

(Homo sapiens) 		PF00071
(Ras) 		4 VAL A 189
ILE A 218
HIS A  99
LEU A 118
 None
 0.98A 4xo7A-2cjwA:
2.5		 4xo7A-2cjwA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvt RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
LARGE CHAIN 1

(Saccharomyces
cerevisiae) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 TYR A 143
VAL A 136
ILE A 135
LEU A 156
 None
 0.91A 4xo7A-2cvtA:
3.1		 4xo7A-2cvtA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN

(Daboia
siamensis) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 VAL A 129
ILE A 128
HIS A  95
LEU A  89
 None
 1.02A 4xo7A-2e3xA:
undetectable		 4xo7A-2e3xA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e54 ACETYLORNITHINE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00202
(Aminotran_3) 		4 VAL A  88
ILE A 252
LEU A 286
LEU A 223
 None
 0.97A 4xo7A-2e54A:
undetectable		 4xo7A-2e54A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL
SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF08442
(ATP-grasp_2) 		4 VAL A 243
ILE A 213
LEU B 275
LEU A 165
 None
 0.99A 4xo7A-2fpgA:
undetectable		 4xo7A-2fpgA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5c PREPHENATE
DEHYDROGENASE

(Aquifex
aeolicus) 		PF02153
(PDH) 		4 VAL A  87
ILE A 114
LEU A 135
LEU A 139
 None
 1.00A 4xo7A-2g5cA:
undetectable		 4xo7A-2g5cA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gb3 ASPARTATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		4 TYR A  80
VAL A 208
ILE A 207
LEU A 277
 None
 0.83A 4xo7A-2gb3A:
undetectable		 4xo7A-2gb3A:
21.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		5 VAL A 128
HIS A 222
TRP A 227
LEU A 306
LEU A 308
 None
NAP  A   1 ( 4.8A)
FFA  A 325 (-3.8A)
FFA  A 325 (-4.8A)
FFA  A 325 (-4.5A)
 0.88A 4xo7A-2ipjA:
56.0		 4xo7A-2ipjA:
99.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ipj ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		5 VAL A 128
ILE A 129
HIS A 222
TRP A 227
LEU A 308
 None
None
NAP  A   1 ( 4.8A)
FFA  A 325 (-3.8A)
FFA  A 325 (-4.5A)
 0.82A 4xo7A-2ipjA:
56.0		 4xo7A-2ipjA:
99.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isq CYSTEINE SYNTHASE

(Arabidopsis
thaliana) 		PF00291
(PALP) 		4 TYR A 158
ILE A 173
LEU A 239
LEU A 202
 None
 1.01A 4xo7A-2isqA:
undetectable		 4xo7A-2isqA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 VAL A 143
ILE A 144
LEU A 157
LEU A 184
 PPF  A 500 (-4.9A)
None
None
None
 0.83A 4xo7A-2it4A:
undetectable		 4xo7A-2it4A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7c BETA-GLUCOSIDASE A

(Thermotoga
maritima) 		PF00232
(Glyco_hydro_1) 		4 TYR A 146
VAL A 158
ILE A 105
LEU A  98
 None
 0.89A 4xo7A-2j7cA:
11.1		 4xo7A-2j7cA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k31 PHOSPHODIESTERASE
5A, CGMP-SPECIFIC

(Mus musculus) 		PF01590
(GAF) 		4 VAL A 269
ILE A 261
LEU A 203
LEU A 194
 None
 0.96A 4xo7A-2k31A:
undetectable		 4xo7A-2k31A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knd PHOTOSYSTEM II 11
KDA PROTEIN

(Synechocystis
sp. PCC 6803) 		PF13326
(PSII_Pbs27) 		4 VAL A  18
ILE A  19
LEU A  91
LEU A  95
 None
 0.84A 4xo7A-2kndA:
undetectable		 4xo7A-2kndA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7e TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 14

(Saccharomyces
cerevisiae) 		PF03366
(YEATS) 		4 VAL A  37
ILE A  36
LEU A 105
LEU A  86
 None
 0.90A 4xo7A-2l7eA:
undetectable		 4xo7A-2l7eA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqc PENICILLIN V ACYLASE

(Bacillus
subtilis) 		PF02275
(CBAH) 		4 VAL A 316
ILE A  30
LEU A 135
LEU A  61
 None
 0.94A 4xo7A-2oqcA:
undetectable		 4xo7A-2oqcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkq GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
B

(Spinacia
oleracea) 		PF00044
(Gp_dh_N)
PF02672
(CP12)
PF02800
(Gp_dh_C) 		4 VAL O 305
ILE O 246
LEU O 218
LEU O 221
 None
 1.02A 4xo7A-2pkqO:
undetectable		 4xo7A-2pkqO:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ppv UNCHARACTERIZED
PROTEIN

(Staphylococcus
epidermidis) 		PF01933
(UPF0052) 		4 VAL A 121
ILE A 122
LEU A 204
LEU A 174
 None
 1.01A 4xo7A-2ppvA:
3.7		 4xo7A-2ppvA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9u A-TYPE FLAVOPROTEIN

(Giardia
intestinalis) 		no annotation 4 VAL A 130
ILE A 129
LEU A  94
LEU A 116
 None
 0.71A 4xo7A-2q9uA:
undetectable		 4xo7A-2q9uA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qw5 XYLOSE
ISOMERASE-LIKE TIM
BARREL

(Trichormus
variabilis) 		PF01261
(AP_endonuc_2) 		4 TYR A 109
ILE A 131
LEU A 168
LEU A 165
 None
 0.97A 4xo7A-2qw5A:
9.1		 4xo7A-2qw5A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyk CYCLIC AMP-SPECIFIC
PHOSPHODIESTERASE
HSPDE4A10

(Homo sapiens) 		PF00233
(PDEase_I) 		4 VAL A 321
ILE A 318
LEU A 406
LEU A 381
 None
 0.81A 4xo7A-2qykA:
undetectable		 4xo7A-2qykA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		4 TYR A 139
ILE A 107
LEU A 257
LEU A 226
 None
 0.84A 4xo7A-2r3aA:
undetectable		 4xo7A-2r3aA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vj5 PROTEIN MXIC

(Shigella
flexneri) 		PF07201
(HrpJ) 		4 VAL A 215
ILE A 248
LEU A 282
LEU A 283
 None
 1.00A 4xo7A-2vj5A:
undetectable		 4xo7A-2vj5A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw THIOSULFATE
REDUCTASE

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 TYR A 202
VAL A 311
ILE A 312
LEU A 354
LEU A 268
 None
 1.39A 4xo7A-2vpwA:
undetectable		 4xo7A-2vpwA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw THIOSULFATE
REDUCTASE

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 VAL A 311
ILE A 307
LEU A 347
LEU A 261
 None
 1.03A 4xo7A-2vpwA:
undetectable		 4xo7A-2vpwA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 VAL A 891
ILE A 890
LEU A 845
LEU A 881
 None
 0.98A 4xo7A-2wanA:
6.1		 4xo7A-2wanA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y35 LD22664P

(Drosophila
melanogaster) 		PF03159
(XRN_N) 		4 VAL A 956
ILE A 957
HIS A 997
LEU A 916
 None
 0.87A 4xo7A-2y35A:
undetectable		 4xo7A-2y35A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		4 TYR A 608
VAL A1012
ILE A1015
LEU A1000
 None
 1.01A 4xo7A-2y3aA:
undetectable		 4xo7A-2y3aA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjg LACTATE RACEMASE
APOPROTEIN

(Thermoanaerobacterium
thermosaccharolyticum) 		PF09861
(DUF2088) 		4 VAL A 372
ILE A 373
LEU A  13
LEU A 395
 None
 0.88A 4xo7A-2yjgA:
undetectable		 4xo7A-2yjgA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgk ANTI-TUMOR LECTIN

(Agrocybe
aegerita) 		PF00337
(Gal-bind_lectin) 		4 VAL A 149
ILE A   8
LEU A  58
LEU A  49
 None
 0.97A 4xo7A-2zgkA:
undetectable		 4xo7A-2zgkA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9g PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrobaculum
aerophilum) 		PF07995
(GSDH) 		4 VAL A 124
ILE A 125
LEU A  60
LEU A  68
 None
 1.01A 4xo7A-3a9gA:
undetectable		 4xo7A-3a9gA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anx SPERMIDINE SYNTHASE

(Thermus
thermophilus) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 ILE A  62
HIS A  98
LEU A 262
LEU A 264
 None
 1.02A 4xo7A-3anxA:
undetectable		 4xo7A-3anxA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b46 AMINOTRANSFERASE
BNA3

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		4 VAL A 142
ILE A 143
LEU A 220
LEU A 223
 None
 0.96A 4xo7A-3b46A:
undetectable		 4xo7A-3b46A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8b CYSQ, SULFITE
SYNTHESIS PATHWAY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00459
(Inositol_P) 		4 TYR A 122
VAL A 168
ILE A 195
LEU A 158
 None
 0.85A 4xo7A-3b8bA:
undetectable		 4xo7A-3b8bA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3k ALANINE RACEMASE

(Actinobacillus
succinogenes) 		PF13377
(Peripla_BP_3) 		4 VAL A  27
ILE A  30
LEU A  59
LEU A  12
 None
 1.01A 4xo7A-3c3kA:
undetectable		 4xo7A-3c3kA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cji POLYPROTEIN

(Senecavirus A) 		no annotation 4 VAL A 235
ILE A  46
LEU A 182
LEU A  75
 None
 0.98A 4xo7A-3cjiA:
undetectable		 4xo7A-3cjiA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvr INVASION PLASMID
ANTIGEN

(Shigella
flexneri) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		4 VAL A  84
ILE A  82
LEU A  71
LEU A  74
 None
 0.96A 4xo7A-3cvrA:
undetectable		 4xo7A-3cvrA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dka DINB-LIKE PROTEIN

(Bacillus
subtilis) 		PF05163
(DinB) 		4 VAL A 115
ILE A 105
LEU A  93
LEU A  96
 None
 0.97A 4xo7A-3dkaA:
undetectable		 4xo7A-3dkaA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsl ZINC
METALLOPROTEINASE-DI
SINTEGRIN
BOTHROPASIN

(Bothrops
jararaca) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 VAL A 129
ILE A 128
HIS A  95
LEU A  89
 None
 0.97A 4xo7A-3dslA:
undetectable		 4xo7A-3dslA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 ILE A 305
HIS A 164
LEU A 183
LEU A 150
 None
 1.02A 4xo7A-3eb0A:
undetectable		 4xo7A-3eb0A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb7 INSECTICIDAL
DELTA-ENDOTOXIN
CRY8EA1

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 VAL A  89
ILE A  92
LEU A 175
LEU A 209
 None
 0.90A 4xo7A-3eb7A:
undetectable		 4xo7A-3eb7A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euj CHROMOSOME PARTITION
PROTEIN MUKB, LINKER

([Haemophilus]
ducreyi) 		PF04310
(MukB)
PF13558
(SbcCD_C) 		4 VAL A1301
ILE A1293
LEU A1433
LEU A1447
 None
 0.96A 4xo7A-3eujA:
undetectable		 4xo7A-3eujA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ew7 LMO0794 PROTEIN

(Listeria
monocytogenes) 		PF13460
(NAD_binding_10) 		4 VAL A 194
ILE A 198
LEU A  86
LEU A  98
 None
 1.00A 4xo7A-3ew7A:
undetectable		 4xo7A-3ew7A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9s PUTATIVE POLYKETIDE
CYCLASE

(Acidithiobacillus
ferrooxidans) 		PF07366
(SnoaL) 		4 TYR A  35
ILE A  24
HIS A 125
LEU A  62
 None
None
GOL  A 146 (-4.1A)
None
 1.00A 4xo7A-3f9sA:
undetectable		 4xo7A-3f9sA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpk FERREDOXIN-NADP
REDUCTASE

(Salmonella
enterica) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 TYR A 121
VAL A 185
ILE A 189
LEU A 109
 None
 1.00A 4xo7A-3fpkA:
undetectable		 4xo7A-3fpkA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)

(Oryza sativa) 		PF01450
(IlvC)
PF07991
(IlvN) 		4 VAL A 258
ILE A 273
LEU A 324
LEU A 501
 None
 1.03A 4xo7A-3fr8A:
undetectable		 4xo7A-3fr8A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		4 VAL A 228
ILE A 229
LEU A 277
LEU A 257
 None
 0.94A 4xo7A-3g06A:
undetectable		 4xo7A-3g06A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gk3 ACETOACETYL-COA
REDUCTASE

(Burkholderia
pseudomallei) 		PF13561
(adh_short_C2) 		4 VAL A 210
ILE A 208
LEU A  16
LEU A 187
 None
 0.89A 4xo7A-3gk3A:
undetectable		 4xo7A-3gk3A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h74 PYRIDOXAL KINASE

(Lactobacillus
plantarum) 		PF08543
(Phos_pyr_kin) 		4 VAL A 135
ILE A 136
LEU A 157
LEU A 161
 None
 0.95A 4xo7A-3h74A:
undetectable		 4xo7A-3h74A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Shewanella
denitrificans) 		PF01380
(SIS) 		4 TYR A 306
VAL A 258
ILE A 260
LEU A 185
 None
 0.95A 4xo7A-3hbaA:
undetectable		 4xo7A-3hbaA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbx GLUTAMATE
DECARBOXYLASE 1

(Arabidopsis
thaliana) 		PF00282
(Pyridoxal_deC) 		4 VAL A 367
ILE A 366
LEU A 433
LEU A 354
 None
 0.83A 4xo7A-3hbxA:
undetectable		 4xo7A-3hbxA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF08668
(HDOD) 		4 ILE A 128
HIS A 250
LEU A 259
LEU A 260
 None
 0.93A 4xo7A-3hc1A:
undetectable		 4xo7A-3hc1A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9f PUTATIVE TYPE 11
METHYLTRANSFERASE

(Sulfolobus
solfataricus) 		PF08241
(Methyltransf_11) 		4 VAL A 108
ILE A 109
LEU A 169
LEU A 171
 None
 0.84A 4xo7A-3i9fA:
undetectable		 4xo7A-3i9fA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k17 LIN0012 PROTEIN

(Listeria
innocua) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 TYR A  18
VAL A 232
ILE A 235
LEU A 283
 None
 0.93A 4xo7A-3k17A:
undetectable		 4xo7A-3k17A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8k ALPHA-AMYLASE, SUSG

(Bacteroides
thetaiotaomicron) 		PF00128
(Alpha-amylase) 		4 VAL A 382
ILE A 146
LEU A 126
LEU A  82
 None
 0.96A 4xo7A-3k8kA:
8.9		 4xo7A-3k8kA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Homo sapiens) 		PF01409
(tRNA-synt_2d)
PF03483
(B3_4)
PF03484
(B5) 		4 VAL B 481
ILE B 480
HIS A 371
LEU B 413
 None
 0.95A 4xo7A-3l4gB:
undetectable		 4xo7A-3l4gB:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6y CATENIN DELTA-1

(Homo sapiens) 		PF00514
(Arm) 		4 VAL A 562
ILE A 561
LEU A 548
LEU A 554
 None
 1.00A 4xo7A-3l6yA:
undetectable		 4xo7A-3l6yA:
19.73