SIMILAR PATTERNS OF AMINO ACIDS FOR 4XK8_A_PQNA845_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aoa | T-FIMBRIN (Homo sapiens) |
PF00307(CH) | 4 | ARG A 220ALA A 216LEU A 219GLY A 161 | ARG A 220 ( 0.6A)ALA A 216 ( 0.0A)LEU A 219 ( 0.6A)GLY A 161 ( 0.0A) | 0.91A | 4xk8a-1aoaA:undetectable | 4xk8a-1aoaA:16.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1csj | HEPATITIS C VIRUSRNA POLYMERASE(NS5B) (Hepacivirus C) |
PF00998(RdRP_3) | 4 | PHE A 526ALA A 510LEU A 511GLY A 522 | None | 0.76A | 4xk8a-1csjA:undetectable | 4xk8a-1csjA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fpz | CYCLIN-DEPENDENTKINASE INHIBITOR 3 (Homo sapiens) |
PF05706(CDKN3) | 4 | SER A 30ALA A 179LEU A 144GLY A 143 | NoneNoneNoneSO4 A 900 ( 4.7A) | 0.85A | 4xk8a-1fpzA:undetectable | 4xk8a-1fpzA:13.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ijl | PHOSPHOLIPASE A2 (Deinagkistrodonacutus) |
PF00068(Phospholip_A2_1) | 4 | MET A 18PHE A 19SER A 22ARG A 110 | None | 0.76A | 4xk8a-1ijlA:2.3 | 4xk8a-1ijlA:8.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jf5 | ALPHA AMYLASE II (Thermoactinomycesvulgaris) |
PF00128(Alpha-amylase)PF02903(Alpha-amylase_N)PF16657(Malt_amylase_C) | 4 | MET A 372SER A 370ALA A 131GLY A 448 | None | 0.86A | 4xk8a-1jf5A:undetectable | 4xk8a-1jf5A:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kv9 | TYPE IIQUINOHEMOPROTEINALCOHOLDEHYDROGENASE (Pseudomonasputida) |
PF13360(PQQ_2)PF13442(Cytochrome_CBB3) | 4 | PHE A 194ARG A 276ALA A 283GLY A 280 | None | 0.77A | 4xk8a-1kv9A:0.0 | 4xk8a-1kv9A:23.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n5x | XANTHINEDEHYDROGENASE (Bos taurus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 4 | PHE A 911ALA A1198LEU A1264GLY A 913 | None | 0.89A | 4xk8a-1n5xA:undetectable | 4xk8a-1n5xA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ogy | PERIPLASMIC NITRATEREDUCTASE (Rhodobactersphaeroides) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF04879(Molybdop_Fe4S4) | 4 | SER A 142ALA A 132LEU A 135GLY A 139 | None | 0.92A | 4xk8a-1ogyA:undetectable | 4xk8a-1ogyA:22.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oy1 | PUTATIVE SIGMACROSS-REACTINGPROTEIN 27A (Escherichiacoli) |
no annotation | 4 | PHE A 42ALA A 86LEU A 89GLY A 8 | None | 0.99A | 4xk8a-1oy1A:undetectable | 4xk8a-1oy1A:13.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rwr | FILAMENTOUSHEMAGGLUTININ (Bordetellapertussis) |
PF05860(Haemagg_act) | 4 | PHE A 39ARG A 87ALA A 89LEU A 88 | None | 0.89A | 4xk8a-1rwrA:undetectable | 4xk8a-1rwrA:18.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sqj | OLIGOXYLOGLUCANREDUCING-END-SPECIFIC CELLOBIOHYDROLASE (Geotrichum sp.M128) |
PF15899(BNR_6) | 4 | SER A 343TRP A 435ALA A 358GLY A 353 | None | 1.00A | 4xk8a-1sqjA:undetectable | 4xk8a-1sqjA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tyj | CELLULOSOMALSCAFFOLDIN (Pseudobacteroidescellulosolvens) |
PF00963(Cohesin) | 4 | ARG A 91ALA A 74LEU A 92GLY A 33 | NoneEDO A 175 (-3.6A)NoneNone | 0.90A | 4xk8a-1tyjA:undetectable | 4xk8a-1tyjA:13.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vpd | TARTRONATESEMIALDEHYDEREDUCTASE (Salmonellaenterica) |
PF03446(NAD_binding_2)PF14833(NAD_binding_11) | 4 | PHE A 7ALA A 46LEU A 28GLY A 6 | None | 0.90A | 4xk8a-1vpdA:undetectable | 4xk8a-1vpdA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yzp | PEROXIDASEMANGANESE-DEPENDENTI (Phanerochaetechrysosporium) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 4 | PHE A 45SER A 172ALA A 272LEU A 276 | HEM A 396 (-3.6A)HEM A 396 (-2.8A)NoneNone | 0.98A | 4xk8a-1yzpA:undetectable | 4xk8a-1yzpA:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zx5 | MANNOSEPHOSPHATEISOMERASE, PUTATIVE (Archaeoglobusfulgidus) |
PF01238(PMI_typeI) | 4 | SER A 186ALA A 192LEU A 191GLY A 115 | NoneNoneNoneEDO A 801 ( 4.2A) | 0.79A | 4xk8a-1zx5A:undetectable | 4xk8a-1zx5A:17.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zzg | GLUCOSE-6-PHOSPHATEISOMERASE (Thermusthermophilus) |
PF00342(PGI) | 4 | TRP A 260ALA A 83LEU A 84GLY A 195 | None | 0.84A | 4xk8a-1zzgA:0.8 | 4xk8a-1zzgA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bac | PUTATIVEAMINOOXIDASE (Cutibacteriumacnes) |
PF01593(Amino_oxidase) | 4 | MET A 190ALA A 113LEU A 117GLY A 118 | None | 1.01A | 4xk8a-2bacA:undetectable | 4xk8a-2bacA:18.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fnu | AMINOTRANSFERASE (Helicobacterpylori) |
PF01041(DegT_DnrJ_EryC1) | 4 | PHE A 179ALA A 246LEU A 243GLY A 239 | None | 0.97A | 4xk8a-2fnuA:undetectable | 4xk8a-2fnuA:18.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iqt | FRUCTOSE-BISPHOSPHATE ALDOLASE CLASS 1 (Porphyromonasgingivalis) |
PF00274(Glycolytic) | 4 | PHE A 15ALA A 262LEU A 263GLY A 17 | None | 0.84A | 4xk8a-2iqtA:undetectable | 4xk8a-2iqtA:17.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j4d | CRYPTOCHROME DASH (Arabidopsisthaliana) |
PF00875(DNA_photolyase)PF03441(FAD_binding_7) | 4 | PHE A 260ALA A 9LEU A 10GLY A 257 | None | 1.01A | 4xk8a-2j4dA:undetectable | 4xk8a-2j4dA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mf4 | HYBRID POLYKETIDESYNTHASE-NONRIBOSOMAL PEPTIDESYNTHETASE (Streptomycesvirginiae) |
PF00550(PP-binding) | 4 | PHE A6776ALA A6792LEU A6793GLY A6773 | None | 0.90A | 4xk8a-2mf4A:undetectable | 4xk8a-2mf4A:6.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mzw | ELONGATION FACTOR G (Staphylococcusaureus) |
PF00679(EFG_C)PF03764(EFG_IV)PF14492(EFG_II) | 4 | ARG A 659ALA A 655LEU A 658GLY A 666 | None | 0.91A | 4xk8a-2mzwA:undetectable | 4xk8a-2mzwA:15.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nux | 2-KETO-3-DEOXYGLUCONATE/2-KETO-3-DEOXY-6-PHOSPHO GLUCONATEALDOLASE (Sulfolobusacidocaldarius) |
PF00701(DHDPS) | 4 | ARG A 234ALA A 230LEU A 233GLY A 237 | None | 0.97A | 4xk8a-2nuxA:undetectable | 4xk8a-2nuxA:17.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q34 | CURF (Mooreaproducens) |
PF00378(ECH_1) | 4 | MET A 111PHE A 131ALA A 138GLY A 177 | None | 1.00A | 4xk8a-2q34A:undetectable | 4xk8a-2q34A:15.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q8n | GLUCOSE-6-PHOSPHATEISOMERASE (Thermotogamaritima) |
PF00342(PGI) | 4 | TRP A 274ALA A 83LEU A 84GLY A 206 | None | 0.80A | 4xk8a-2q8nA:undetectable | 4xk8a-2q8nA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qyf | MAD2L1-BINDINGPROTEIN (Homo sapiens) |
PF06581(p31comet) | 4 | PHE B 60ARG B 249ALA B 173LEU B 172 | None | 0.97A | 4xk8a-2qyfB:undetectable | 4xk8a-2qyfB:14.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qyk | CYCLIC AMP-SPECIFICPHOSPHODIESTERASEHSPDE4A10 (Homo sapiens) |
PF00233(PDEase_I) | 4 | MET A 334PHE A 338ALA A 404LEU A 403 | None | 1.00A | 4xk8a-2qykA:undetectable | 4xk8a-2qykA:17.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wkn | FORMAMIDASE (Delftiaacidovorans) |
PF03069(FmdA_AmdA) | 4 | SER A 363ALA A 331LEU A 375GLY A 360 | None | 0.88A | 4xk8a-2wknA:undetectable | 4xk8a-2wknA:19.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wqk | 5'-NUCLEOTIDASE SURE (Aquifexaeolicus) |
PF01975(SurE) | 4 | PHE A 125ALA A 19LEU A 20GLY A 92 | None | 0.96A | 4xk8a-2wqkA:undetectable | 4xk8a-2wqkA:15.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xhz | ARABINOSE5-PHOSPHATEISOMERASE (Escherichiacoli) |
PF01380(SIS) | 4 | MET A 67PHE A 71ALA A 177LEU A 178 | None | 1.01A | 4xk8a-2xhzA:undetectable | 4xk8a-2xhzA:12.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y4l | MANNOSYLGLYCERATESYNTHASE (Rhodothermusmarinus) |
no annotation | 4 | SER A 157ALA A 378LEU A 149GLY A 146 | None | 0.91A | 4xk8a-2y4lA:undetectable | 4xk8a-2y4lA:18.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y93 | CIS-2,3-DIHYDROBIPHENYL-2,3-DIOLDEHYDROGENASE (Comamonastestosteroni) |
PF00106(adh_short) | 4 | ARG A 43ALA A 39LEU A 42GLY A 55 | None | 0.72A | 4xk8a-2y93A:undetectable | 4xk8a-2y93A:16.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yky | BETA-TRANSAMINASE (Mesorhizobiumsp. LUK) |
PF00202(Aminotran_3) | 5 | PHE A 348ARG A 259ALA A 416LEU A 417GLY A 345 | None | 1.26A | 4xk8a-2ykyA:undetectable | 4xk8a-2ykyA:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ylz | PHENYLACETONEMONOOXYGENASE (Thermobifidafusca) |
PF13738(Pyr_redox_3) | 4 | MET A 148PHE A 433SER A 150GLY A 436 | NoneNoneFAD A 700 (-4.9A)None | 1.00A | 4xk8a-2ylzA:undetectable | 4xk8a-2ylzA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aqs | BACTERIAL REGULATORYPROTEINS, TETRFAMILY (Corynebacteriumglutamicum) |
PF00440(TetR_N) | 4 | PHE A 159ARG A 203ALA A 212LEU A 202 | None | 1.02A | 4xk8a-3aqsA:undetectable | 4xk8a-3aqsA:16.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3beh | MLL3241 PROTEIN (Mesorhizobiumloti) |
PF07885(Ion_trans_2) | 4 | PHE A 214ALA A 207LEU A 210GLY A 213 | None | 0.97A | 4xk8a-3behA:undetectable | 4xk8a-3behA:20.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ch2 | SERINE-REPEATANTIGEN PROTEIN (Plasmodiumfalciparum) |
PF00112(Peptidase_C1) | 4 | PHE X 811SER X 708ALA X 760GLY X 756 | None | 0.97A | 4xk8a-3ch2X:undetectable | 4xk8a-3ch2X:13.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cnh | HYDROLASE FAMILYPROTEIN (Deinococcusradiodurans) |
PF13419(HAD_2) | 4 | TRP A 19ALA A 46LEU A 49GLY A 110 | None | 0.80A | 4xk8a-3cnhA:undetectable | 4xk8a-3cnhA:13.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ddu | PROLYL ENDOPEPTIDASE (Homo sapiens) |
PF00326(Peptidase_S9)PF02897(Peptidase_S9_N) | 4 | SER A 604ALA A 521LEU A 520GLY A 600 | None | 0.94A | 4xk8a-3dduA:undetectable | 4xk8a-3dduA:24.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ghy | KETOPANTOATEREDUCTASE PROTEIN (Ralstoniasolanacearum) |
PF02558(ApbA)PF08546(ApbA_C) | 4 | SER A 174ALA A 181LEU A 166GLY A 167 | None | 0.81A | 4xk8a-3ghyA:undetectable | 4xk8a-3ghyA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i83 | 2-DEHYDROPANTOATE2-REDUCTASE (Methylococcuscapsulatus) |
PF02558(ApbA)PF08546(ApbA_C) | 4 | SER A 156ALA A 163LEU A 148GLY A 149 | None | 0.73A | 4xk8a-3i83A:undetectable | 4xk8a-3i83A:15.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jwe | MGLL PROTEIN (Homo sapiens) |
PF12146(Hydrolase_4) | 4 | PHE A 219ALA A 226LEU A 223GLY A 220 | NoneNoneF4P A 314 ( 4.3A)None | 0.99A | 4xk8a-3jweA:undetectable | 4xk8a-3jweA:17.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lmm | UNCHARACTERIZEDPROTEIN (Corynebacteriumdiphtheriae) |
PF04326(AlbA_2)PF13749(HATPase_c_4) | 4 | PHE A 232SER A 263ALA A 194LEU A 193 | None | 0.96A | 4xk8a-3lmmA:undetectable | 4xk8a-3lmmA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n29 | CARBOXYNORSPERMIDINEDECARBOXYLASE (Campylobacterjejuni) |
PF00278(Orn_DAP_Arg_deC) | 4 | PHE A 102ALA A 159LEU A 120GLY A 121 | None | 0.95A | 4xk8a-3n29A:undetectable | 4xk8a-3n29A:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ps0 | CRISPR-ASSOCIATEDPROTEIN, CSA2 (Sulfolobussolfataricus) |
PF01905(DevR) | 4 | PHE A 186ALA A 54LEU A 139GLY A 140 | None | 0.87A | 4xk8a-3ps0A:undetectable | 4xk8a-3ps0A:17.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rlf | MALTOSE TRANSPORTSYSTEM PERMEASEPROTEIN MALGMALTOSE/MALTODEXTRINIMPORT ATP-BINDINGPROTEIN MALK (Escherichiacoli) |
PF00005(ABC_tran)PF00528(BPD_transp_1)PF08402(TOBE_2) | 4 | ARG A 146ALA G 191LEU G 194GLY A 78 | None | 1.01A | 4xk8a-3rlfA:undetectable | 4xk8a-3rlfA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sqz | PUTATIVEHYDROXYMETHYLGLUTARYL-COA SYNTHASE (Streptococcusmutans) |
PF00195(Chal_sti_synt_N)PF08540(HMG_CoA_synt_C) | 4 | SER A 12ALA A 41LEU A 42GLY A 154 | None | 0.94A | 4xk8a-3sqzA:undetectable | 4xk8a-3sqzA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sqz | PUTATIVEHYDROXYMETHYLGLUTARYL-COA SYNTHASE (Streptococcusmutans) |
PF00195(Chal_sti_synt_N)PF08540(HMG_CoA_synt_C) | 4 | SER A 13ALA A 41LEU A 42GLY A 154 | None | 0.72A | 4xk8a-3sqzA:undetectable | 4xk8a-3sqzA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tzw | POLYKETIDE SYNTHASEPKS13 (Mycobacteriumtuberculosis) |
PF00698(Acyl_transf_1) | 4 | ARG A 690ALA A 642LEU A 689GLY A 688 | None | 0.91A | 4xk8a-3tzwA:undetectable | 4xk8a-3tzwA:21.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w0l | GLUCOKINASE (Xenopus laevis) |
PF00349(Hexokinase_1)PF03727(Hexokinase_2) | 4 | PHE A 141ALA A 194LEU A 139GLY A 140 | None | 0.97A | 4xk8a-3w0lA:undetectable | 4xk8a-3w0lA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w1h | L-SERYL-TRNA(SEC)SELENIUM TRANSFERASE (Aquifexaeolicus) |
PF03841(SelA) | 4 | PHE A 147ALA A 311LEU A 314GLY A 144 | None | 0.93A | 4xk8a-3w1hA:undetectable | 4xk8a-3w1hA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w1j | L-SERYL-TRNA(SEC)SELENIUM TRANSFERASE (Aquifexaeolicus) |
PF03841(SelA) | 4 | PHE A 147ALA A 311LEU A 314GLY A 144 | None | 0.91A | 4xk8a-3w1jA:undetectable | 4xk8a-3w1jA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wrf | NON-REDUCING ENDBETA-L-ARABINOFURANOSIDASE (Bifidobacteriumlongum) |
PF07944(Glyco_hydro_127) | 4 | PHE A 467SER A 465LEU A 536GLY A 471 | None | 1.02A | 4xk8a-3wrfA:0.5 | 4xk8a-3wrfA:23.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a01 | PROTONPYROPHOSPHATASE (Vigna radiata) |
PF03030(H_PPase) | 4 | PHE A 108ALA A 137LEU A 136GLY A 112 | None | 0.93A | 4xk8a-4a01A:undetectable | 4xk8a-4a01A:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cuk | D-LACTATEDEHYDROGENASE (Salmonellaenterica) |
PF00389(2-Hacid_dh)PF02826(2-Hacid_dh_C) | 4 | MET A 142PHE A 166ALA A 159GLY A 165 | None | 0.83A | 4xk8a-4cukA:undetectable | 4xk8a-4cukA:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eun | THERMORESISTANTGLUCOKINASE (Janibacter sp.HTCC2649) |
PF01202(SKI) | 4 | MET A 127PHE A 126SER A 15ALA A 37 | None | 0.67A | 4xk8a-4eunA:undetectable | 4xk8a-4eunA:14.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gpc | HEME OXYGENASE (Corynebacteriumdiphtheriae) |
PF01126(Heme_oxygenase) | 4 | MET A 29PHE A 28SER A 26GLY A 212 | BLA A 901 (-3.6A)NoneNoneNone | 0.81A | 4xk8a-4gpcA:undetectable | 4xk8a-4gpcA:15.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hrt | GLOBIN-2 A CHAIN (Scapharcainaequivalvis) |
PF00042(Globin) | 4 | PHE A 111ALA A 148LEU A 149GLY A 108 | HEM A 201 (-3.8A)NoneNoneNone | 1.02A | 4xk8a-4hrtA:undetectable | 4xk8a-4hrtA:11.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i3g | BETA-GLUCOSIDASE (Streptomycesvenezuelae) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 4 | MET A 534PHE A 532ALA A 506GLY A 531 | None | 0.65A | 4xk8a-4i3gA:undetectable | 4xk8a-4i3gA:22.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ncj | DNA DOUBLE-STRANDBREAK REPAIR RAD50ATPASE (Pyrococcusfuriosus) |
PF02463(SMC_N) | 4 | MET A 808PHE A 804ALA A 145GLY A 801 | None | 0.80A | 4xk8a-4ncjA:undetectable | 4xk8a-4ncjA:17.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nme | PROLINEDEHYDROGENASE ANDDELTA-1-PYRROLINE-5-CARBOXYLATEDEHYDROGENASE (Geobactersulfurreducens) |
PF00171(Aldedh)PF01619(Pro_dh) | 4 | PHE A 17ARG A 361ALA A 365GLY A 14 | None | 0.86A | 4xk8a-4nmeA:undetectable | 4xk8a-4nmeA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o9u | NAD(P)TRANSHYDROGENASESUBUNIT BETA (Thermusthermophilus) |
PF02233(PNTB) | 4 | PHE B 220ALA B 116LEU B 120GLY B 121 | None | 0.99A | 4xk8a-4o9uB:undetectable | 4xk8a-4o9uB:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p72 | PHENYLALANINE--TRNALIGASE BETA SUBUNIT (Pseudomonasaeruginosa) |
PF01588(tRNA_bind)PF03147(FDX-ACB)PF03483(B3_4)PF03484(B5) | 4 | PHE A 524SER A 547TRP A 549ALA A 592 | None | 1.01A | 4xk8a-4p72A:undetectable | 4xk8a-4p72A:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pfr | TRAP DICARBOXYLATETRANSPORTER, DCTPSUBUNIT (Rhodobactersphaeroides) |
PF03480(DctP) | 4 | PHE A 45ALA A 137LEU A 138GLY A 257 | None | 0.85A | 4xk8a-4pfrA:undetectable | 4xk8a-4pfrA:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pph | CONGLUTIN GAMMA (Lupinusangustifolius) |
PF14541(TAXi_C)PF14543(TAXi_N) | 4 | SER A 105ALA A 119LEU A 118GLY A 102 | EDO A 509 ( 4.9A)NoneNoneNone | 1.01A | 4xk8a-4pphA:undetectable | 4xk8a-4pphA:19.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ppr | PENICILLIN-BINDINGPROTEIN DACB1 (Mycobacteriumtuberculosis) |
PF00768(Peptidase_S11) | 4 | PHE A 330ALA A 323LEU A 326GLY A 329 | None | 0.98A | 4xk8a-4pprA:undetectable | 4xk8a-4pprA:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r9o | PUTATIVE ALDO/KETOREDUCTASE (Salmonellaenterica) |
PF00248(Aldo_ket_red) | 4 | PHE A 64ALA A 71LEU A 68GLY A 65 | None | 0.79A | 4xk8a-4r9oA:undetectable | 4xk8a-4r9oA:16.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rdc | AMINO ACID/AMIDE ABCTRANSPORTERSUBSTRATE-BINDINGPROTEIN, HAAT FAMILY (Trichormusvariabilis) |
PF13458(Peripla_BP_6) | 4 | SER A 205ALA A 257LEU A 282GLY A 279 | None | 0.97A | 4xk8a-4rdcA:undetectable | 4xk8a-4rdcA:18.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4rku | PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A1 (Pisum sativum) |
PF00223(PsaA_PsaB) | 8 | MET A 691PHE A 692SER A 695ARG A 697TRP A 700ALA A 724LEU A 725GLY A 730 | CLA A9013 ( 3.6A)PQN A5001 (-3.6A)PQN A5001 (-3.5A)NonePQN A5001 ( 3.4A)PQN A5001 (-3.4A)PQN A5001 ( 3.7A)PQN A5001 ( 4.0A) | 0.30A | 4xk8a-4rkuA:45.4 | 4xk8a-4rkuA:99.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4rku | PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A2 (Pisum sativum) |
PF00223(PsaA_PsaB) | 7 | MET B 662PHE B 663SER B 666ARG B 668TRP B 671ALA B 699LEU B 700 | CLA B9023 ( 3.3A)PQN B5002 ( 4.3A)PQN B5002 (-3.2A)NonePQN B5002 ( 3.3A)PQN B5002 (-3.2A)PQN B5002 (-3.7A) | 0.49A | 4xk8a-4rkuB:34.5 | 4xk8a-4rkuB:44.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4roq | MALYL-COALYASE/BETA-METHYLMALYL-COA LYASE (Methylobacteriumextorquens) |
PF03328(HpcH_HpaI) | 4 | PHE A 250ARG A 223ALA A 160GLY A 252 | None | 1.00A | 4xk8a-4roqA:undetectable | 4xk8a-4roqA:18.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rxl | MOLYBDENUM ABCTRANSPORTER,PERIPLASMICMOLYBDENUM-BINDINGPROTEIN (Vibrio cholerae) |
PF13531(SBP_bac_11) | 4 | SER A 105ALA A 195LEU A 196GLY A 248 | None | 0.86A | 4xk8a-4rxlA:undetectable | 4xk8a-4rxlA:14.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4usc | PEROXIDASE (Trachycarpusfortunei) |
PF00141(peroxidase) | 4 | ARG A 123ALA A 102LEU A 101GLY A 51 | None | 1.01A | 4xk8a-4uscA:undetectable | 4xk8a-4uscA:17.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xu4 | UNCHARACTERIZEDPROTEIN (Mycolicibacteriumvanbaalenii) |
no annotation | 4 | PHE A 171ALA A 61LEU A 60GLY A 172 | DDQ A 303 (-3.5A)NoneNoneNone | 0.94A | 4xk8a-4xu4A:undetectable | 4xk8a-4xu4A:13.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a2o | NITRATE TRANSPORTER1.1 (Arabidopsisthaliana) |
PF00854(PTR2) | 4 | PHE A 429ALA A 477LEU A 478GLY A 426 | None | 0.81A | 4xk8a-5a2oA:undetectable | 4xk8a-5a2oA:24.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bsz | N-METHYLTRANSFERASE (Streptoalloteichussp. ATCC 53650) |
PF13649(Methyltransf_25) | 4 | ARG A 243ALA A 133LEU A 142GLY A 241 | None | 0.96A | 4xk8a-5bszA:undetectable | 4xk8a-5bszA:16.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5egn | ESTERASE (unculturedbacterium) |
PF12697(Abhydrolase_6) | 4 | PHE A 142ALA A 149LEU A 146GLY A 143 | None | 1.00A | 4xk8a-5egnA:undetectable | 4xk8a-5egnA:15.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f9k | DEOXYURIDINE5'-TRIPHOSPHATENUCLEOTIDOHYDROLASE (Dictyosteliumdiscoideum) |
PF00692(dUTPase) | 4 | SER A 31ALA A 43LEU A 44GLY A 89 | None | 1.02A | 4xk8a-5f9kA:undetectable | 4xk8a-5f9kA:11.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gqr | LEUCINE-RICH REPEATRECEPTOR-LIKEPROTEIN KINASE TDR (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13855(LRR_8) | 4 | PHE B 245ARG B 220ALA B 195GLY B 222 | None | 0.81A | 4xk8a-5gqrB:undetectable | 4xk8a-5gqrB:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hcc | COMPLEMENT C5 (Homo sapiens) |
PF01835(A2M_N)PF07703(A2M_N_2) | 4 | SER B 556ALA B 649LEU B 648GLY B 639 | None | 0.97A | 4xk8a-5hccB:undetectable | 4xk8a-5hccB:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l75 | FIG000906: PREDICTEDPERMEASE (Klebsiellapneumoniae) |
PF03739(YjgP_YjgQ) | 4 | PHE G 319ALA G 72LEU G 73GLY G 316 | None | 0.81A | 4xk8a-5l75G:2.0 | 4xk8a-5l75G:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l9s | ABC TRANSPORTER,SUBSTRATE BINDINGPROTEIN (MANNOPINE) (Agrobacteriumfabrum) |
PF13416(SBP_bac_8) | 4 | PHE A 266ALA A 192LEU A 191GLY A 264 | None | 1.01A | 4xk8a-5l9sA:undetectable | 4xk8a-5l9sA:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ol2 | ACYL-COADEHYDROGENASE (Clostridioidesdifficile) |
no annotation | 4 | ARG C 350ALA C 27LEU C 30GLY C 205 | None | 0.86A | 4xk8a-5ol2C:2.3 | 4xk8a-5ol2C:19.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oy0 | PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A1 (Synechocystissp. PCC 6803) |
no annotation | 8 | MET 1 684PHE 1 685SER 1 688ARG 1 690TRP 1 693ALA 1 717LEU 1 718GLY 1 723 | CLA 1 802 ( 3.2A)PQN 1 842 (-3.8A)PQN 1 842 (-3.4A)NonePQN 1 842 ( 3.3A)PQN 1 842 (-3.2A)PQN 1 842 ( 3.6A)PQN 1 842 ( 3.9A) | 0.27A | 4xk8a-5oy01:45.1 | 4xk8a-5oy01:8.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oy0 | PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A2 (Synechocystissp. PCC 6803) |
no annotation | 7 | MET b 659PHE b 660SER b 663ARG b 665TRP b 668ALA b 696LEU b 697 | CLA b1807 ( 3.2A)PQN b1844 ( 4.2A)PQN b1844 (-3.7A)NonePQN b1844 ( 3.4A)PQN b1844 (-3.2A)PQN b1844 ( 3.8A) | 0.59A | 4xk8a-5oy0b:34.6 | 4xk8a-5oy0b:15.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tir | SUPEROXIDE DISMUTASE (Trichodermareesei) |
no annotation | 4 | PHE A 6ALA A 45LEU A 46GLY A 4 | None | 0.94A | 4xk8a-5tirA:undetectable | 4xk8a-5tirA:13.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tr1 | CHLORIDE CHANNELPROTEIN (Bos taurus) |
PF00654(Voltage_CLC) | 4 | MET A 421SER A 107ALA A 156LEU A 155 | None | 0.98A | 4xk8a-5tr1A:undetectable | 4xk8a-5tr1A:24.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v8k | P800 REACTION CENTERCORE PROTEIN (Heliobacteriummodesticaldum) |
PF00223(PsaA_PsaB) | 4 | ARG A 551ALA A 580LEU A 581GLY A 586 | NoneAOH A1003 ( 4.9A)NoneNone | 0.60A | 4xk8a-5v8kA:22.1 | 4xk8a-5v8kA:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v8k | P800 REACTION CENTERCORE PROTEIN (Heliobacteriummodesticaldum) |
PF00223(PsaA_PsaB) | 4 | SER A 545ARG A 551ALA A 580GLY A 586 | AOH A1003 (-4.3A)NoneAOH A1003 ( 4.9A)None | 0.88A | 4xk8a-5v8kA:22.1 | 4xk8a-5v8kA:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5voh | NADH OXIDASE (Lactobacillusbrevis) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | SER A 336ALA A 343LEU A 339GLY A 386 | None | 0.99A | 4xk8a-5vohA:undetectable | 4xk8a-5vohA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wml | - (-) |
no annotation | 4 | MET A 364ALA A 350LEU A 353GLY A 358 | None | 0.88A | 4xk8a-5wmlA:undetectable | 4xk8a-5wmlA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x7v | NUCLEOSOME ASSEMBLYPROTEIN (Plasmodiumfalciparum) |
PF00956(NAP) | 4 | PHE A 123TRP A 80ALA A 81LEU A 101 | None | 0.94A | 4xk8a-5x7vA:undetectable | 4xk8a-5x7vA:13.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xfo | PHD FINGER PROTEIN 1 (Homo sapiens) |
PF00628(PHD) | 4 | PHE A 316ALA A 333LEU A 331GLY A 330 | None | 0.85A | 4xk8a-5xfoA:undetectable | 4xk8a-5xfoA:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xn7 | PUTATIVE RTX-TOXIN (Vibriovulnificus) |
PF11647(MLD) | 4 | PHE A2871ALA A2878LEU A2875GLY A2872 | None | 0.91A | 4xk8a-5xn7A:undetectable | 4xk8a-5xn7A:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yqr | ENDOLYSIN/MEMBRANE-ANCHOREDLIPID-BINDINGPROTEIN LAM6 FUSIONPROTEIN (Escherichiavirus T4;Saccharomycescerevisiae) |
no annotation | 4 | MET A 6SER A 1TRP A 158GLY A1159 | None | 0.80A | 4xk8a-5yqrA:undetectable | 4xk8a-5yqrA:7.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c26 | DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEINGLYCOSYLTRANSFERASESUBUNIT STT3 (Saccharomycescerevisiae) |
no annotation | 4 | PHE A 149ALA A 142LEU A 145GLY A 148 | None | 1.01A | 4xk8a-6c26A:undetectable | 4xk8a-6c26A:7.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6fos | PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A1 (Cyanidioschyzonmerolae) |
no annotation | 5 | MET A 681PHE A 682ARG A 687TRP A 690ALA A 714 | PQN A2001 ( 3.3A)PQN A2001 (-4.3A)NonePQN A2001 ( 3.2A)PQN A2001 (-3.2A) | 0.70A | 4xk8a-6fosA:42.2 | 4xk8a-6fosA:82.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6fos | PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A1 (Cyanidioschyzonmerolae) |
no annotation | 6 | MET A 681PHE A 682TRP A 690ALA A 714LEU A 715GLY A 720 | PQN A2001 ( 3.3A)PQN A2001 (-4.3A)PQN A2001 ( 3.2A)PQN A2001 (-3.2A)PQN A2001 (-3.7A)None | 0.58A | 4xk8a-6fosA:42.2 | 4xk8a-6fosA:82.50 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6fos | PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A1 (Cyanidioschyzonmerolae) |
no annotation | 4 | SER A 685ARG A 687TRP A 690ALA A 714 | PQN A2001 (-4.4A)NonePQN A2001 ( 3.2A)PQN A2001 (-3.2A) | 0.89A | 4xk8a-6fosA:42.2 | 4xk8a-6fosA:82.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fos | PHOTOSYSTEM I P700CHLOROPHYLL AAPOPROTEIN A2 (Cyanidioschyzonmerolae) |
no annotation | 7 | MET B 660PHE B 661SER B 664ARG B 666TRP B 669ALA B 697LEU B 698 | PQN B2002 ( 3.2A)PQN B2002 ( 4.3A)CLA B1023 (-4.5A)NonePQN B2002 (-3.3A)PQN B2002 (-3.1A)PQN B2002 (-3.6A) | 0.82A | 4xk8a-6fosB:27.3 | 4xk8a-6fosB:7.28 |