SIMILAR PATTERNS OF AMINO ACIDS FOR 4XIW_A_AZMA402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd0 CARBONIC ANHYDRASE
XII


(Homo sapiens)
PF00194
(Carb_anhydrase)
11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 4.5A)
ZN  A 901 ( 3.1A)
AZM  A1400 (-4.6A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
0.41A 4xiwA-1jd0A:
25.5
4xiwH-1jd0A:
25.5
4xiwA-1jd0A:
29.71
4xiwH-1jd0A:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd0 CARBONIC ANHYDRASE
XII


(Homo sapiens)
PF00194
(Carb_anhydrase)
6 HIS A  94
GLU A 117
HIS A 119
VAL A 121
VAL A 143
TRP A 209
ZN  A 901 ( 3.2A)
None
ZN  A 901 ( 3.1A)
AZM  A1400 (-4.6A)
AZM  A1400 ( 4.9A)
None
1.48A 4xiwA-1jd0A:
25.5
4xiwH-1jd0A:
25.5
4xiwA-1jd0A:
29.71
4xiwH-1jd0A:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd0 CARBONIC ANHYDRASE
XII


(Homo sapiens)
PF00194
(Carb_anhydrase)
6 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
THR A 200
ZN  A 901 ( 3.2A)
ZN  A 901 ( 4.5A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
0.91A 4xiwA-1jd0A:
25.5
4xiwH-1jd0A:
25.5
4xiwA-1jd0A:
29.71
4xiwH-1jd0A:
29.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd0 CARBONIC ANHYDRASE
XII


(Homo sapiens)
PF00194
(Carb_anhydrase)
6 HIS A 119
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
ZN  A 901 ( 3.1A)
ZN  A 901 ( 3.2A)
AZM  A1400 ( 4.9A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
1.44A 4xiwA-1jd0A:
25.5
4xiwH-1jd0A:
25.5
4xiwA-1jd0A:
29.71
4xiwH-1jd0A:
29.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae)
PF00194
(Carb_anhydrase)
7 GLN A  69
HIS A  92
HIS A  94
GLU A  98
LEU A 176
THR A 177
THR A 178
None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 4.6A)
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
1.12A 4xiwA-1kopA:
28.5
4xiwH-1kopA:
28.1
4xiwA-1kopA:
38.58
4xiwH-1kopA:
38.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae)
PF00194
(Carb_anhydrase)
6 GLN A  69
HIS A  94
GLU A  98
VAL A 113
LEU A 176
THR A 178
None
ZN  A 301 ( 3.3A)
ZN  A 301 ( 4.6A)
None
AZI  A 305 (-4.2A)
AZI  A 305 ( 4.2A)
1.21A 4xiwA-1kopA:
28.5
4xiwH-1kopA:
28.1
4xiwA-1kopA:
38.58
4xiwH-1kopA:
38.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae)
PF00194
(Carb_anhydrase)
7 GLN A  90
HIS A  92
GLU A 109
HIS A 111
VAL A 113
VAL A 123
TRP A 187
None
ZN  A 301 ( 3.2A)
None
ZN  A 301 ( 3.2A)
None
None
None
1.47A 4xiwA-1kopA:
28.5
4xiwH-1kopA:
28.1
4xiwA-1kopA:
38.58
4xiwH-1kopA:
38.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae)
PF00194
(Carb_anhydrase)
11 GLN A  90
HIS A  92
HIS A  94
GLU A  98
HIS A 111
VAL A 113
VAL A 123
LEU A 176
THR A 177
THR A 178
TRP A 187
None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 4.6A)
ZN  A 301 ( 3.2A)
None
None
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
None
0.33A 4xiwA-1kopA:
28.5
4xiwH-1kopA:
28.1
4xiwA-1kopA:
38.58
4xiwH-1kopA:
38.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV


(Mus musculus)
PF00194
(Carb_anhydrase)
7 GLN A  67
HIS A  94
HIS A  96
GLU A 106
LEU A 198
THR A 199
THR A 200
None
ZN  A 601 ( 3.3A)
ZN  A 601 (-3.3A)
ZN  A 601 ( 4.5A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
1.12A 4xiwA-1rj6A:
26.3
4xiwH-1rj6A:
26.3
4xiwA-1rj6A:
29.30
4xiwH-1rj6A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV


(Mus musculus)
PF00194
(Carb_anhydrase)
6 GLN A  67
HIS A  96
GLU A 106
VAL A 121
LEU A 198
THR A 200
None
ZN  A 601 (-3.3A)
ZN  A 601 ( 4.5A)
AZM  A 400 (-4.8A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
1.20A 4xiwA-1rj6A:
26.3
4xiwH-1rj6A:
26.3
4xiwA-1rj6A:
29.30
4xiwH-1rj6A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV


(Mus musculus)
PF00194
(Carb_anhydrase)
11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
AZM  A 400 (-4.3A)
ZN  A 601 ( 3.3A)
ZN  A 601 (-3.3A)
ZN  A 601 ( 4.5A)
ZN  A 601 ( 3.2A)
AZM  A 400 (-4.8A)
None
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
None
0.39A 4xiwA-1rj6A:
26.3
4xiwH-1rj6A:
26.3
4xiwA-1rj6A:
29.30
4xiwH-1rj6A:
29.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV


(Mus musculus)
PF00194
(Carb_anhydrase)
6 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
THR A 200
ZN  A 601 (-3.3A)
ZN  A 601 ( 4.5A)
None
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
0.94A 4xiwA-1rj6A:
26.3
4xiwH-1rj6A:
26.3
4xiwA-1rj6A:
29.30
4xiwH-1rj6A:
29.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus)
PF00194
(Carb_anhydrase)
7 GLN A  67
HIS A  94
GLU A 106
HIS A 119
LEU A 198
THR A 199
THR A 200
None
ZN  A 280 (-3.2A)
ZN  A 280 ( 4.7A)
ZN  A 280 (-3.2A)
None
ZN  A 280 ( 4.9A)
None
1.30A 4xiwA-1urtA:
24.6
4xiwH-1urtA:
24.5
4xiwA-1urtA:
35.59
4xiwH-1urtA:
35.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus)
PF00194
(Carb_anhydrase)
6 GLN A  92
HIS A  94
GLU A 117
VAL A 121
VAL A 143
THR A 199
None
ZN  A 280 (-3.2A)
None
None
None
ZN  A 280 ( 4.9A)
1.35A 4xiwA-1urtA:
24.6
4xiwH-1urtA:
24.5
4xiwA-1urtA:
35.59
4xiwH-1urtA:
35.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus)
PF00194
(Carb_anhydrase)
11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
None
ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
ZN  A 280 ( 4.7A)
ZN  A 280 (-3.2A)
None
None
None
ZN  A 280 ( 4.9A)
None
None
0.37A 4xiwA-1urtA:
24.6
4xiwH-1urtA:
24.5
4xiwA-1urtA:
35.59
4xiwH-1urtA:
35.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus)
PF00194
(Carb_anhydrase)
7 GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 143
LEU A 198
THR A 199
None
ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
None
None
ZN  A 280 ( 4.9A)
1.36A 4xiwA-1urtA:
24.6
4xiwH-1urtA:
24.5
4xiwA-1urtA:
35.59
4xiwH-1urtA:
35.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus)
PF00194
(Carb_anhydrase)
6 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
THR A 200
ZN  A 280 (-3.2A)
ZN  A 280 ( 4.7A)
None
None
ZN  A 280 ( 4.9A)
None
0.82A 4xiwA-1urtA:
24.6
4xiwH-1urtA:
24.5
4xiwA-1urtA:
35.59
4xiwH-1urtA:
35.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1urt CARBONIC ANHYDRASE V

(Mus musculus)
PF00194
(Carb_anhydrase)
6 HIS A 119
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
None
ZN  A 280 ( 4.9A)
None
1.39A 4xiwA-1urtA:
24.6
4xiwH-1urtA:
24.5
4xiwA-1urtA:
35.59
4xiwH-1urtA:
35.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)


(Dunaliella
salina)
PF00194
(Carb_anhydrase)
7 GLN A 113
HIS A 115
GLU A 133
HIS A 135
VAL A 137
VAL A 153
TRP A 227
None
ZN  A 283 ( 3.2A)
None
ZN  A 283 ( 3.1A)
ACY  A 279 ( 4.7A)
None
None
1.41A 4xiwA-1y7wA:
22.9
4xiwH-1y7wA:
23.0
4xiwA-1y7wA:
31.13
4xiwH-1y7wA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)


(Dunaliella
salina)
PF00194
(Carb_anhydrase)
11 GLN A 113
HIS A 115
HIS A 117
GLU A 122
HIS A 135
VAL A 137
VAL A 153
LEU A 216
THR A 217
THR A 218
TRP A 227
None
ZN  A 283 ( 3.2A)
ZN  A 283 (-3.2A)
ZN  A 283 ( 4.5A)
ZN  A 283 ( 3.1A)
ACY  A 279 ( 4.7A)
None
ACY  A 279 (-4.3A)
ACY  A 279 (-3.4A)
ACY  A 279 ( 4.9A)
None
0.29A 4xiwA-1y7wA:
22.9
4xiwH-1y7wA:
23.0
4xiwA-1y7wA:
31.13
4xiwH-1y7wA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)


(Dunaliella
salina)
PF00194
(Carb_anhydrase)
6 HIS A 115
HIS A 135
LEU A 216
THR A 217
THR A 218
TRP A 227
ZN  A 283 ( 3.2A)
ZN  A 283 ( 3.1A)
ACY  A 279 (-4.3A)
ACY  A 279 (-3.4A)
ACY  A 279 ( 4.9A)
None
1.50A 4xiwA-1y7wA:
22.9
4xiwH-1y7wA:
23.0
4xiwA-1y7wA:
31.13
4xiwH-1y7wA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)


(Dunaliella
salina)
PF00194
(Carb_anhydrase)
6 HIS A 117
GLU A 122
VAL A 153
LEU A 216
THR A 217
THR A 218
ZN  A 283 (-3.2A)
ZN  A 283 ( 4.5A)
None
ACY  A 279 (-4.3A)
ACY  A 279 (-3.4A)
ACY  A 279 ( 4.9A)
0.85A 4xiwA-1y7wA:
22.9
4xiwH-1y7wA:
23.0
4xiwA-1y7wA:
31.13
4xiwH-1y7wA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens)
PF00194
(Carb_anhydrase)
9 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
TRP A 209
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
0.58A 4xiwA-2it4A:
26.1
4xiwH-2it4A:
26.0
4xiwA-2it4A:
32.58
4xiwH-2it4A:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens)
PF00194
(Carb_anhydrase)
6 HIS A  96
GLU A 106
HIS A 119
VAL A 143
LEU A 198
THR A 199
ZN  A 561 ( 3.2A)
ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
0.99A 4xiwA-2it4A:
26.1
4xiwH-2it4A:
26.0
4xiwA-2it4A:
32.58
4xiwH-2it4A:
32.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN


(Homo sapiens)
PF00194
(Carb_anhydrase)
6 HIS A 118
GLU A 128
HIS A 141
LEU A 222
THR A 223
TRP A 233
CL  A 401 (-4.2A)
None
CL  A 401 (-4.1A)
None
CL  A 401 ( 4.8A)
None
0.28A 4xiwA-2w2jA:
25.5
4xiwH-2w2jA:
25.5
4xiwA-2w2jA:
30.90
4xiwH-2w2jA:
30.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV


(Mus musculus)
PF00194
(Carb_anhydrase)
11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
None
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
ZN  A   1 ( 4.8A)
ZN  A   1 ( 3.2A)
None
None
None
ZN  A   1 ( 4.7A)
None
None
0.35A 4xiwA-2zncA:
25.6
4xiwH-2zncA:
25.3
4xiwA-2zncA:
34.20
4xiwH-2zncA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV


(Mus musculus)
PF00194
(Carb_anhydrase)
6 HIS A  94
GLU A 117
HIS A 119
VAL A 121
VAL A 143
TRP A 209
ZN  A   1 ( 3.3A)
None
ZN  A   1 ( 3.2A)
None
None
None
1.44A 4xiwA-2zncA:
25.6
4xiwH-2zncA:
25.3
4xiwA-2zncA:
34.20
4xiwH-2zncA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV


(Mus musculus)
PF00194
(Carb_anhydrase)
6 HIS A  94
HIS A 119
VAL A 143
LEU A 198
THR A 200
TRP A 209
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.2A)
None
None
None
None
1.46A 4xiwA-2zncA:
25.6
4xiwH-2zncA:
25.3
4xiwA-2zncA:
34.20
4xiwH-2zncA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV


(Mus musculus)
PF00194
(Carb_anhydrase)
6 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
THR A 200
ZN  A   1 ( 3.3A)
ZN  A   1 ( 4.8A)
None
None
ZN  A   1 ( 4.7A)
None
0.77A 4xiwA-2zncA:
25.6
4xiwH-2zncA:
25.3
4xiwA-2zncA:
34.20
4xiwH-2zncA:
34.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2znc CARBONIC ANHYDRASE
IV


(Mus musculus)
PF00194
(Carb_anhydrase)
6 HIS A 119
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
ZN  A   1 ( 3.2A)
ZN  A   1 ( 3.3A)
None
None
ZN  A   1 ( 4.7A)
None
1.37A 4xiwA-2zncA:
25.6
4xiwH-2zncA:
25.3
4xiwA-2zncA:
34.20
4xiwH-2zncA:
34.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii)
PF00194
(Carb_anhydrase)
7 GLN A 115
HIS A 163
HIS A 165
GLU A 169
HIS A 182
THR A 260
THR A 261
None
ZN  A 378 (-3.2A)
ZN  A 378 (-3.3A)
ZN  A 378 ( 4.5A)
ZN  A 378 (-3.1A)
ZN  A 378 ( 4.5A)
None
1.04A 4xiwA-3b1bA:
26.6
4xiwH-3b1bA:
26.4
4xiwA-3b1bA:
25.52
4xiwH-3b1bA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii)
PF00194
(Carb_anhydrase)
5 GLN A 115
HIS A 165
GLU A 169
VAL A 184
THR A 261
None
ZN  A 378 (-3.3A)
ZN  A 378 ( 4.5A)
None
None
0.93A 4xiwA-3b1bA:
26.6
4xiwH-3b1bA:
26.4
4xiwA-3b1bA:
25.52
4xiwH-3b1bA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii)
PF00194
(Carb_anhydrase)
7 GLN A 161
HIS A 163
GLU A 180
HIS A 182
VAL A 184
VAL A 201
TRP A 270
None
ZN  A 378 (-3.2A)
None
ZN  A 378 (-3.1A)
None
None
None
1.47A 4xiwA-3b1bA:
26.6
4xiwH-3b1bA:
26.4
4xiwA-3b1bA:
25.52
4xiwH-3b1bA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii)
PF00194
(Carb_anhydrase)
11 GLN A 161
HIS A 163
HIS A 165
GLU A 169
HIS A 182
VAL A 184
VAL A 201
LEU A 259
THR A 260
THR A 261
TRP A 270
None
ZN  A 378 (-3.2A)
ZN  A 378 (-3.3A)
ZN  A 378 ( 4.5A)
ZN  A 378 (-3.1A)
None
None
None
ZN  A 378 ( 4.5A)
None
None
0.27A 4xiwA-3b1bA:
26.6
4xiwH-3b1bA:
26.4
4xiwA-3b1bA:
25.52
4xiwH-3b1bA:
25.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii)
PF00194
(Carb_anhydrase)
6 HIS A 165
GLU A 169
VAL A 201
LEU A 259
THR A 260
THR A 261
ZN  A 378 (-3.3A)
ZN  A 378 ( 4.5A)
None
None
ZN  A 378 ( 4.5A)
None
0.92A 4xiwA-3b1bA:
26.6
4xiwH-3b1bA:
26.4
4xiwA-3b1bA:
25.52
4xiwH-3b1bA:
25.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13


(Homo sapiens)
PF00194
(Carb_anhydrase)
9 HIS A  95
HIS A  97
GLU A 107
HIS A 120
VAL A 122
VAL A 144
LEU A 199
THR A 200
TRP A 210
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
ZN  A 301 ( 4.9A)
ZN  A 301 ( 3.2A)
4MD  A 401 ( 4.6A)
4MD  A 401 ( 4.4A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
0.42A 4xiwA-3da2A:
25.8
4xiwH-3da2A:
25.6
4xiwA-3da2A:
30.74
4xiwH-3da2A:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13


(Homo sapiens)
PF00194
(Carb_anhydrase)
5 HIS A  97
GLU A 107
VAL A 122
LEU A 199
THR A 200
ZN  A 301 ( 3.5A)
ZN  A 301 ( 4.9A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
0.84A 4xiwA-3da2A:
25.8
4xiwH-3da2A:
25.6
4xiwA-3da2A:
30.74
4xiwH-3da2A:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens)
PF00194
(Carb_anhydrase)
6 GLN A 109
HIS A 111
GLU A 136
HIS A 138
VAL A 140
TRP A 230
None
MG  A 901 (-3.4A)
None
MG  A 901 (-3.2A)
None
None
1.40A 4xiwA-3fe4A:
24.5
4xiwH-3fe4A:
24.2
4xiwA-3fe4A:
32.30
4xiwH-3fe4A:
32.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens)
PF00194
(Carb_anhydrase)
10 GLN A 109
HIS A 111
HIS A 113
GLU A 125
HIS A 138
VAL A 140
VAL A 161
LEU A 219
THR A 220
TRP A 230
None
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
MG  A 901 ( 4.4A)
MG  A 901 (-3.2A)
None
None
None
None
None
0.72A 4xiwA-3fe4A:
24.5
4xiwH-3fe4A:
24.2
4xiwA-3fe4A:
32.30
4xiwH-3fe4A:
32.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens)
PF00194
(Carb_anhydrase)
5 GLU A 125
LEU A 219
THR A 220
THR A 221
TRP A 230
MG  A 901 ( 4.4A)
None
None
None
None
0.69A 4xiwA-3fe4A:
24.5
4xiwH-3fe4A:
24.2
4xiwA-3fe4A:
32.30
4xiwH-3fe4A:
32.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens)
PF00194
(Carb_anhydrase)
6 HIS A 111
HIS A 113
VAL A 140
VAL A 161
LEU A 219
THR A 220
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
None
None
None
None
1.43A 4xiwA-3fe4A:
24.5
4xiwH-3fe4A:
24.2
4xiwA-3fe4A:
32.30
4xiwH-3fe4A:
32.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA


(Homo sapiens)
PF00194
(Carb_anhydrase)
5 HIS A 129
GLU A 141
LEU A 235
THR A 236
TRP A 246
None
0.26A 4xiwA-3jxfA:
25.5
4xiwH-3jxfA:
25.2
4xiwA-3jxfA:
26.24
4xiwH-3jxfA:
26.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens)
PF00194
(Carb_anhydrase)
5 GLN A  67
HIS A  96
GLU A 106
VAL A 121
THR A 200
None
ZN  A 263 ( 3.2A)
ZN  A 263 ( 4.6A)
AZM  A 264 (-4.7A)
AZM  A 264 (-3.5A)
0.93A 4xiwA-3ml5A:
26.0
4xiwH-3ml5A:
25.6
4xiwA-3ml5A:
34.91
4xiwH-3ml5A:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens)
PF00194
(Carb_anhydrase)
7 GLN A  92
HIS A  94
GLU A 117
HIS A 119
VAL A 121
VAL A 143
TRP A 209
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
None
ZN  A 263 ( 3.1A)
AZM  A 264 (-4.7A)
AZM  A 264 ( 4.9A)
None
1.41A 4xiwA-3ml5A:
26.0
4xiwH-3ml5A:
25.6
4xiwA-3ml5A:
34.91
4xiwH-3ml5A:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens)
PF00194
(Carb_anhydrase)
11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 4.6A)
ZN  A 263 ( 3.1A)
AZM  A 264 (-4.7A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
0.29A 4xiwA-3ml5A:
26.0
4xiwH-3ml5A:
25.6
4xiwA-3ml5A:
34.91
4xiwH-3ml5A:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens)
PF00194
(Carb_anhydrase)
6 HIS A 119
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
ZN  A 263 ( 3.1A)
ZN  A 263 ( 3.2A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
1.44A 4xiwA-3ml5A:
26.0
4xiwH-3ml5A:
25.6
4xiwA-3ml5A:
34.91
4xiwH-3ml5A:
34.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae)
PF00194
(Carb_anhydrase)
6 GLN A 102
HIS A 123
HIS A 125
GLU A 129
THR A 215
THR A 216
None
ZN  A   1 ( 3.2A)
ZN  A   1 (-3.3A)
ZN  A   1 ( 4.7A)
MLT  A   3 ( 4.3A)
MLT  A   3 (-2.8A)
1.14A 4xiwA-3q31A:
23.2
4xiwH-3q31A:
23.1
4xiwA-3q31A:
32.09
4xiwH-3q31A:
32.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae)
PF00194
(Carb_anhydrase)
6 GLN A 102
HIS A 125
GLU A 129
VAL A 144
THR A 215
THR A 216
None
ZN  A   1 (-3.3A)
ZN  A   1 ( 4.7A)
None
MLT  A   3 ( 4.3A)
MLT  A   3 (-2.8A)
1.12A 4xiwA-3q31A:
23.2
4xiwH-3q31A:
23.1
4xiwA-3q31A:
32.09
4xiwH-3q31A:
32.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae)
PF00194
(Carb_anhydrase)
7 GLN A 121
HIS A 123
GLU A 140
HIS A 142
VAL A 144
VAL A 154
TRP A 225
MLT  A   3 (-3.9A)
ZN  A   1 ( 3.2A)
None
ZN  A   1 ( 3.2A)
None
MLT  A   3 (-4.6A)
MLT  A   3 (-4.9A)
1.43A 4xiwA-3q31A:
23.2
4xiwH-3q31A:
23.1
4xiwA-3q31A:
32.09
4xiwH-3q31A:
32.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae)
PF00194
(Carb_anhydrase)
11 GLN A 121
HIS A 123
HIS A 125
GLU A 129
HIS A 142
VAL A 144
VAL A 154
LEU A 214
THR A 215
THR A 216
TRP A 225
MLT  A   3 (-3.9A)
ZN  A   1 ( 3.2A)
ZN  A   1 (-3.3A)
ZN  A   1 ( 4.7A)
ZN  A   1 ( 3.2A)
None
MLT  A   3 (-4.6A)
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
MLT  A   3 (-2.8A)
MLT  A   3 (-4.9A)
0.44A 4xiwA-3q31A:
23.2
4xiwH-3q31A:
23.1
4xiwA-3q31A:
32.09
4xiwH-3q31A:
32.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae)
PF00194
(Carb_anhydrase)
6 HIS A 123
HIS A 142
VAL A 154
LEU A 214
THR A 216
TRP A 225
ZN  A   1 ( 3.2A)
ZN  A   1 ( 3.2A)
MLT  A   3 (-4.6A)
MLT  A   3 ( 4.2A)
MLT  A   3 (-2.8A)
MLT  A   3 (-4.9A)
1.44A 4xiwA-3q31A:
23.2
4xiwH-3q31A:
23.1
4xiwA-3q31A:
32.09
4xiwH-3q31A:
32.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens)
PF00194
(Carb_anhydrase)
10 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 121
VAL A 142
THR A 198
THR A 199
TRP A 208
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
ZN  A 261 ( 4.9A)
ZN  A 261 (-3.2A)
None
None
ZN  A 261 ( 4.4A)
None
None
0.47A 4xiwA-3uyqA:
25.8
4xiwH-3uyqA:
25.9
4xiwA-3uyqA:
31.05
4xiwH-3uyqA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens)
PF00194
(Carb_anhydrase)
6 GLN A  92
HIS A  94
HIS A  96
VAL A 121
VAL A 142
THR A 198
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
None
ZN  A 261 ( 4.4A)
1.21A 4xiwA-3uyqA:
25.8
4xiwH-3uyqA:
25.9
4xiwA-3uyqA:
31.05
4xiwH-3uyqA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens)
PF00194
(Carb_anhydrase)
5 HIS A  96
GLU A 106
VAL A 142
THR A 198
THR A 199
ZN  A 261 (-3.3A)
ZN  A 261 ( 4.9A)
None
ZN  A 261 ( 4.4A)
None
0.69A 4xiwA-3uyqA:
25.8
4xiwH-3uyqA:
25.9
4xiwA-3uyqA:
31.05
4xiwH-3uyqA:
31.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE


(Sulfurihydrogenibium
sp. YO3AOP1)
PF00194
(Carb_anhydrase)
7 GLN A  87
HIS A  89
GLU A 106
HIS A 108
VAL A 110
VAL A 120
TRP A 184
AZM  A 302 (-4.4A)
ZN  A 301 ( 3.2A)
None
ZN  A 301 ( 3.1A)
AZM  A 302 (-4.7A)
AZM  A 302 ( 4.8A)
None
1.44A 4xiwA-4g7aA:
28.0
4xiwH-4g7aA:
27.9
4xiwA-4g7aA:
32.71
4xiwH-4g7aA:
32.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE


(Sulfurihydrogenibium
sp. YO3AOP1)
PF00194
(Carb_anhydrase)
11 GLN A  87
HIS A  89
HIS A  91
GLU A  95
HIS A 108
VAL A 110
VAL A 120
LEU A 173
THR A 174
THR A 175
TRP A 184
AZM  A 302 (-4.4A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.6A)
ZN  A 301 ( 3.1A)
AZM  A 302 (-4.7A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
AZM  A 302 (-3.4A)
None
0.25A 4xiwA-4g7aA:
28.0
4xiwH-4g7aA:
27.9
4xiwA-4g7aA:
32.71
4xiwH-4g7aA:
32.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE


(Sulfurihydrogenibium
sp. YO3AOP1)
PF00194
(Carb_anhydrase)
6 HIS A  89
HIS A  91
VAL A 120
LEU A 173
THR A 174
THR A 175
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
AZM  A 302 (-3.4A)
1.01A 4xiwA-4g7aA:
28.0
4xiwH-4g7aA:
27.9
4xiwA-4g7aA:
32.71
4xiwH-4g7aA:
32.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4g7a CARBONATE
DEHYDRATASE


(Sulfurihydrogenibium
sp. YO3AOP1)
PF00194
(Carb_anhydrase)
6 HIS A 108
HIS A  91
VAL A 120
LEU A 173
THR A 174
THR A 175
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
AZM  A 302 (-3.4A)
1.43A 4xiwA-4g7aA:
28.0
4xiwH-4g7aA:
27.9
4xiwA-4g7aA:
32.71
4xiwH-4g7aA:
32.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqs HYPOTHETICAL PROTEIN

(Bacteroides
uniformis)
PF06283
(ThuA)
5 HIS A 120
HIS A  48
GLU A  45
HIS A 234
TRP A 148
None
0.85A 4xiwA-4jqsA:
undetectable
4xiwH-4jqsA:
undetectable
4xiwA-4jqsA:
22.79
4xiwH-4jqsA:
22.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens)
PF00194
(Carb_anhydrase)
7 GLN A  92
HIS A  94
GLU A 117
HIS A 119
VAL A 121
VAL A 143
TRP A 209
None
ZN  A 301 (-3.2A)
None
ZN  A 301 (-3.1A)
None
None
None
1.40A 4xiwA-4qk3A:
26.7
4xiwH-4qk3A:
26.8
4xiwA-4qk3A:
34.85
4xiwH-4qk3A:
34.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens)
PF00194
(Carb_anhydrase)
11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.5A)
ZN  A 301 (-3.1A)
None
None
None
ZN  A 301 ( 4.4A)
None
None
0.29A 4xiwA-4qk3A:
26.7
4xiwH-4qk3A:
26.8
4xiwA-4qk3A:
34.85
4xiwH-4qk3A:
34.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens)
PF00194
(Carb_anhydrase)
6 HIS A  94
HIS A 119
LEU A 198
THR A 199
THR A 200
TRP A 209
ZN  A 301 (-3.2A)
ZN  A 301 (-3.1A)
None
ZN  A 301 ( 4.4A)
None
None
1.47A 4xiwA-4qk3A:
26.7
4xiwH-4qk3A:
26.8
4xiwA-4qk3A:
34.85
4xiwH-4qk3A:
34.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens)
PF00194
(Carb_anhydrase)
6 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
THR A 200
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.5A)
None
None
ZN  A 301 ( 4.4A)
None
0.85A 4xiwA-4qk3A:
26.7
4xiwH-4qk3A:
26.8
4xiwA-4qk3A:
34.85
4xiwH-4qk3A:
34.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4twl DIOSCORIN 5

(Dioscorea
japonica)
PF00194
(Carb_anhydrase)
6 HIS A  97
GLU A 101
VAL A 116
VAL A 126
THR A 183
TRP A 193
ASC  A 303 (-4.4A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-4.2A)
ASC  A 303 ( 4.5A)
ASC  A 303 (-3.4A)
ASC  A 303 (-4.3A)
0.31A 4xiwA-4twlA:
26.1
4xiwH-4twlA:
25.9
4xiwA-4twlA:
34.50
4xiwH-4twlA:
34.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE


(Thermovibrio
ammonificans)
PF00194
(Carb_anhydrase)
7 GLN A 110
HIS A 112
GLU A 129
HIS A 131
VAL A 133
VAL A 143
TRP A 208
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
None
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
None
1.41A 4xiwA-4uovA:
28.9
4xiwH-4uovA:
28.8
4xiwA-4uovA:
37.74
4xiwH-4uovA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE


(Thermovibrio
ammonificans)
PF00194
(Carb_anhydrase)
11 GLN A 110
HIS A 112
HIS A 114
GLU A 118
HIS A 131
VAL A 133
VAL A 143
LEU A 197
THR A 198
THR A 199
TRP A 208
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.4A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
0.29A 4xiwA-4uovA:
28.9
4xiwH-4uovA:
28.8
4xiwA-4uovA:
37.74
4xiwH-4uovA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4uov CARBONATE
DEHYDRATASE


(Thermovibrio
ammonificans)
PF00194
(Carb_anhydrase)
6 HIS A 112
HIS A 114
VAL A 143
LEU A 197
THR A 198
THR A 199
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
1.02A 4xiwA-4uovA:
28.9
4xiwH-4uovA:
28.8
4xiwA-4uovA:
37.74
4xiwH-4uovA:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)


(Sulfurihydrogenibium
azorense)
PF00194
(Carb_anhydrase)
6 GLN A  67
HIS A  91
GLU A  95
VAL A 110
LEU A 173
THR A 175
None
ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.5A)
AZM  A 302 (-4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
1.21A 4xiwA-4x5sA:
29.1
4xiwH-4x5sA:
28.9
4xiwA-4x5sA:
37.25
4xiwH-4x5sA:
37.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)


(Sulfurihydrogenibium
azorense)
PF00194
(Carb_anhydrase)
7 GLN A  87
HIS A  89
GLU A 106
HIS A 108
VAL A 110
VAL A 120
TRP A 184
AZM  A 302 (-4.3A)
ZN  A 301 ( 3.1A)
None
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.8A)
AZM  A 302 ( 4.8A)
None
1.45A 4xiwA-4x5sA:
29.1
4xiwH-4x5sA:
28.9
4xiwA-4x5sA:
37.25
4xiwH-4x5sA:
37.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)


(Sulfurihydrogenibium
azorense)
PF00194
(Carb_anhydrase)
11 GLN A  87
HIS A  89
HIS A  91
GLU A  95
HIS A 108
VAL A 110
VAL A 120
LEU A 173
THR A 174
THR A 175
TRP A 184
AZM  A 302 (-4.3A)
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.5A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.8A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
None
0.28A 4xiwA-4x5sA:
29.1
4xiwH-4x5sA:
28.9
4xiwA-4x5sA:
37.25
4xiwH-4x5sA:
37.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)


(Sulfurihydrogenibium
azorense)
PF00194
(Carb_anhydrase)
6 HIS A  89
HIS A  91
VAL A 120
LEU A 173
THR A 174
THR A 175
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
1.00A 4xiwA-4x5sA:
29.1
4xiwH-4x5sA:
28.9
4xiwA-4x5sA:
37.25
4xiwH-4x5sA:
37.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)


(Sulfurihydrogenibium
azorense)
PF00194
(Carb_anhydrase)
6 HIS A  91
GLU A  95
VAL A 110
LEU A 173
THR A 174
THR A 175
ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.5A)
AZM  A 302 (-4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
0.99A 4xiwA-4x5sA:
29.1
4xiwH-4x5sA:
28.9
4xiwA-4x5sA:
37.25
4xiwH-4x5sA:
37.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xfw ALPHA-CARBONIC
ANHYDRASE


(Helicobacter
pylori)
PF00194
(Carb_anhydrase)
9 HIS A 110
HIS A 112
GLU A 116
HIS A 129
VAL A 131
VAL A 141
LEU A 190
THR A 191
TRP A 201
ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
ZN  A 301 (-4.9A)
ZN  A 301 ( 3.1A)
None
None
None
ZN  A 301 (-4.3A)
None
0.41A 4xiwA-4xfwA:
25.9
4xiwH-4xfwA:
25.6
4xiwA-4xfwA:
33.33
4xiwH-4xfwA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE


(Chlamydomonas
reinhardtii)
PF00194
(Carb_anhydrase)
6 GLN A 138
HIS A 162
GLU A 166
VAL A 181
LEU A 253
THR A 255
None
ZN  A 401 ( 3.2A)
2HP  A 402 ( 4.7A)
None
2HP  A 402 (-3.4A)
2HP  A 402 (-3.6A)
1.05A 4xiwA-4xixA:
42.8
4xiwH-4xixA:
40.3
4xiwA-4xixA:
100.00
4xiwH-4xixA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE


(Chlamydomonas
reinhardtii)
PF00194
(Carb_anhydrase)
11 GLN A 158
HIS A 160
HIS A 162
GLU A 166
HIS A 179
VAL A 181
VAL A 192
LEU A 253
THR A 254
THR A 255
TRP A 264
None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
2HP  A 402 ( 4.7A)
ZN  A 401 ( 3.1A)
None
None
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
2HP  A 402 (-3.6A)
None
0.15A 4xiwA-4xixA:
42.8
4xiwH-4xixA:
40.3
4xiwA-4xixA:
100.00
4xiwH-4xixA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE


(Chlamydomonas
reinhardtii)
PF00194
(Carb_anhydrase)
6 HIS A 162
GLU A 166
VAL A 192
LEU A 253
THR A 254
THR A 255
ZN  A 401 ( 3.2A)
2HP  A 402 ( 4.7A)
None
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
2HP  A 402 (-3.6A)
0.94A 4xiwA-4xixA:
42.8
4xiwH-4xixA:
40.3
4xiwA-4xixA:
100.00
4xiwH-4xixA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY


(Hydrogenovibrio
crunogenus)
PF00194
(Carb_anhydrase)
7 GLN A 163
HIS A 165
GLU A 182
HIS A 184
VAL A 186
VAL A 196
TRP A 262
None
ZN  A 401 ( 3.2A)
None
ZN  A 401 ( 3.1A)
None
None
None
1.41A 4xiwA-4xz5A:
28.4
4xiwH-4xz5A:
28.6
4xiwA-4xz5A:
40.80
4xiwH-4xz5A:
40.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY


(Hydrogenovibrio
crunogenus)
PF00194
(Carb_anhydrase)
11 GLN A 163
HIS A 165
HIS A 167
GLU A 171
HIS A 184
VAL A 186
VAL A 196
LEU A 251
THR A 252
THR A 253
TRP A 262
None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 4.5A)
ZN  A 401 ( 3.1A)
None
None
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
None
0.34A 4xiwA-4xz5A:
28.4
4xiwH-4xz5A:
28.6
4xiwA-4xz5A:
40.80
4xiwH-4xz5A:
40.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY


(Hydrogenovibrio
crunogenus)
PF00194
(Carb_anhydrase)
7 HIS A 167
GLU A 171
HIS A 184
VAL A 196
LEU A 251
THR A 252
THR A 253
ZN  A 401 ( 3.3A)
ZN  A 401 ( 4.5A)
ZN  A 401 ( 3.1A)
None
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
0.95A 4xiwA-4xz5A:
28.4
4xiwH-4xz5A:
28.6
4xiwA-4xz5A:
40.80
4xiwH-4xz5A:
40.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY


(Hydrogenovibrio
crunogenus)
PF00194
(Carb_anhydrase)
6 HIS A 184
HIS A 167
VAL A 196
LEU A 251
THR A 252
THR A 253
ZN  A 401 ( 3.1A)
ZN  A 401 ( 3.3A)
None
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
1.45A 4xiwA-4xz5A:
28.4
4xiwH-4xz5A:
28.6
4xiwA-4xz5A:
40.80
4xiwH-4xz5A:
40.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14


(Homo sapiens)
PF00194
(Carb_anhydrase)
5 GLN A  67
HIS A  96
GLU A 106
VAL A 121
THR A 200
GOL  A 303 (-3.4A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 4.6A)
520  A 302 ( 4.9A)
GOL  A 303 ( 3.5A)
0.90A 4xiwA-5cjfA:
26.2
4xiwH-5cjfA:
26.1
4xiwA-5cjfA:
30.34
4xiwH-5cjfA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14


(Homo sapiens)
PF00194
(Carb_anhydrase)
7 GLN A  92
HIS A  94
GLU A 117
HIS A 119
VAL A 121
VAL A 143
TRP A 209
GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
None
ZN  A 301 ( 3.1A)
520  A 302 ( 4.9A)
520  A 302 ( 4.9A)
None
1.43A 4xiwA-5cjfA:
26.2
4xiwH-5cjfA:
26.1
4xiwA-5cjfA:
30.34
4xiwH-5cjfA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14


(Homo sapiens)
PF00194
(Carb_anhydrase)
11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 4.6A)
ZN  A 301 ( 3.1A)
520  A 302 ( 4.9A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
0.23A 4xiwA-5cjfA:
26.2
4xiwH-5cjfA:
26.1
4xiwA-5cjfA:
30.34
4xiwH-5cjfA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5cjf CARBONIC ANHYDRASE
14


(Homo sapiens)
PF00194
(Carb_anhydrase)
6 HIS A  96
GLU A 106
VAL A 143
LEU A 198
THR A 199
THR A 200
ZN  A 301 ( 3.2A)
ZN  A 301 ( 4.6A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
0.90A 4xiwA-5cjfA:
26.2
4xiwH-5cjfA:
26.1
4xiwA-5cjfA:
30.34
4xiwH-5cjfA:
30.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA


(Mus musculus)
PF00194
(Carb_anhydrase)
6 HIS A 151
GLU A 162
LEU A 256
THR A 257
THR A 258
TRP A 267
None
0.30A 4xiwA-5e5uA:
25.1
4xiwH-5e5uA:
24.7
4xiwA-5e5uA:
30.07
4xiwH-5e5uA:
30.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus)
PF00194
(Carb_anhydrase)
7 GLN X  91
HIS X  93
GLU X 116
HIS X 118
VAL X 120
VAL X 141
TRP X 207
None
ZN  X 301 (-3.2A)
None
ZN  X 301 (-3.1A)
None
None
None
1.41A 4xiwA-5eztX:
26.1
4xiwH-5eztX:
26.3
4xiwA-5eztX:
33.83
4xiwH-5eztX:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus)
PF00194
(Carb_anhydrase)
11 GLN X  91
HIS X  93
HIS X  95
GLU X 105
HIS X 118
VAL X 120
VAL X 141
LEU X 196
THR X 197
THR X 198
TRP X 207
None
ZN  X 301 (-3.2A)
ZN  X 301 (-3.2A)
ZN  X 301 ( 4.6A)
ZN  X 301 (-3.1A)
None
None
None
ZN  X 301 ( 4.4A)
None
None
0.34A 4xiwA-5eztX:
26.1
4xiwH-5eztX:
26.3
4xiwA-5eztX:
33.83
4xiwH-5eztX:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus)
PF00194
(Carb_anhydrase)
6 HIS X  95
GLU X 105
VAL X 141
LEU X 196
THR X 197
THR X 198
ZN  X 301 (-3.2A)
ZN  X 301 ( 4.6A)
None
None
ZN  X 301 ( 4.4A)
None
0.89A 4xiwA-5eztX:
26.1
4xiwH-5eztX:
26.3
4xiwA-5eztX:
33.83
4xiwH-5eztX:
33.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum)
PF00194
(Carb_anhydrase)
7 GLN A  94
HIS A  96
GLU A 113
HIS A 115
VAL A 117
VAL A 127
TRP A 192
None
ZN  A 301 (-3.2A)
None
ZN  A 301 (-3.1A)
None
None
None
1.45A 4xiwA-5hpjA:
27.9
4xiwH-5hpjA:
27.6
4xiwA-5hpjA:
36.55
4xiwH-5hpjA:
36.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum)
PF00194
(Carb_anhydrase)
11 GLN A  94
HIS A  96
HIS A  98
GLU A 102
HIS A 115
VAL A 117
VAL A 127
LEU A 181
THR A 182
THR A 183
TRP A 192
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.6A)
ZN  A 301 (-3.1A)
None
None
None
ZN  A 301 ( 4.4A)
None
None
0.37A 4xiwA-5hpjA:
27.9
4xiwH-5hpjA:
27.6
4xiwA-5hpjA:
36.55
4xiwH-5hpjA:
36.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum)
PF00194
(Carb_anhydrase)
6 HIS A  98
GLU A 102
VAL A 117
LEU A 181
THR A 182
THR A 183
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.6A)
None
None
ZN  A 301 ( 4.4A)
None
1.06A 4xiwA-5hpjA:
27.9
4xiwH-5hpjA:
27.6
4xiwA-5hpjA:
36.55
4xiwH-5hpjA:
36.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens)
PF00194
(Carb_anhydrase)
11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 4.6A)
ZN  A 301 ( 3.2A)
EZL  A 302 (-4.7A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
None
0.35A 4xiwA-5jn9A:
25.8
4xiwH-5jn9A:
25.3
4xiwA-5jn9A:
34.89
4xiwH-5jn9A:
34.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens)
PF00194
(Carb_anhydrase)
6 HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
1.04A 4xiwA-5jn9A:
25.8
4xiwH-5jn9A:
25.3
4xiwA-5jn9A:
34.89
4xiwH-5jn9A:
34.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina)
no annotation 7 GLN A 115
HIS A 117
GLU A 134
HIS A 136
VAL A 138
VAL A 148
TRP A 212
None
ZN  A 301 (-3.3A)
None
ZN  A 301 (-3.2A)
None
None
None
1.36A 4xiwA-6ekiA:
28.9
4xiwH-6ekiA:
28.7
4xiwA-6ekiA:
16.90
4xiwH-6ekiA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina)
no annotation 11 GLN A 115
HIS A 117
HIS A 119
GLU A 123
HIS A 136
VAL A 138
VAL A 148
LEU A 201
THR A 202
THR A 203
TRP A 212
None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.2A)
None
None
None
ZN  A 301 (-4.4A)
None
None
0.26A 4xiwA-6ekiA:
28.9
4xiwH-6ekiA:
28.7
4xiwA-6ekiA:
16.90
4xiwH-6ekiA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eki CARBONIC ANHYDRASE

(Persephonella
marina)
no annotation 6 HIS A 119
GLU A 123
VAL A 138
LEU A 201
THR A 202
THR A 203
ZN  A 301 (-3.3A)
ZN  A 301 ( 4.7A)
None
None
ZN  A 301 (-4.4A)
None
0.99A 4xiwA-6ekiA:
28.9
4xiwH-6ekiA:
28.7
4xiwA-6ekiA:
16.90
4xiwH-6ekiA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens)
no annotation 9 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
LEU A 198
THR A 199
THR A 200
VAL A 131
V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-4.2A)
ZN  A 301 ( 3.1A)
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
V14  A 302 ( 4.6A)
1.26A 4xiwA-6fe1A:
26.6
4xiwH-6fe1A:
26.4
4xiwA-6fe1A:
17.14
4xiwH-6fe1A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens)
no annotation 11 GLN A  92
HIS A  94
HIS A  96
GLU A 106
HIS A 119
VAL A 121
VAL A 143
LEU A 198
THR A 199
THR A 200
TRP A 209
V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-4.2A)
ZN  A 301 ( 3.1A)
V14  A 302 (-4.7A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
0.42A 4xiwA-6fe1A:
26.6
4xiwH-6fe1A:
26.4
4xiwA-6fe1A:
17.14
4xiwH-6fe1A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens)
no annotation 6 HIS A  94
GLU A 117
HIS A 119
VAL A 121
VAL A 143
TRP A 209
ZN  A 301 ( 3.2A)
None
ZN  A 301 ( 3.1A)
V14  A 302 (-4.7A)
None
None
1.47A 4xiwA-6fe1A:
26.6
4xiwH-6fe1A:
26.4
4xiwA-6fe1A:
17.14
4xiwH-6fe1A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens)
no annotation 6 HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
0.96A 4xiwA-6fe1A:
26.6
4xiwH-6fe1A:
26.4
4xiwA-6fe1A:
17.14
4xiwH-6fe1A:
17.14