SIMILAR PATTERNS OF AMINO ACIDS FOR 4XI3_B_29SB601_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aos ARGININOSUCCINATE
LYASE

(Homo sapiens) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		4 LEU A 199
GLU A 219
LEU A 107
HIS A  89
 None
 1.05A 4xi3B-1aosA:
undetectable		 4xi3B-1aosA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcn DELTA 2 CRYSTALLIN

(Anas
platyrhynchos) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		4 LEU A 201
GLU A 221
LEU A 109
HIS A  91
 None
 1.12A 4xi3B-1dcnA:
1.0		 4xi3B-1dcnA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp3 N-ACYL-D-GLUCOSAMINE
2-EPIMERASE

(Sus scrofa) 		PF07221
(GlcNAc_2-epim) 		4 LEU A 268
GLU A 329
LEU A 186
HIS A 208
 None
 1.09A 4xi3B-1fp3A:
0.4		 4xi3B-1fp3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2w BETA-LACTAMASE

(Bacillus
licheniformis) 		PF13354
(Beta-lactamase2) 		4 LEU A  81
GLU A 205
MET A 211
LEU A 127
 None
 1.20A 4xi3B-1i2wA:
0.0		 4xi3B-1i2wA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5p PESTICIDIAL CRYSTAL
PROTEIN CRY2AA

(Bacillus
thuringiensis) 		PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
PF09131
(Endotoxin_mid) 		4 LEU A 173
GLU A  98
MET A  90
LEU A 117
 None
 1.37A 4xi3B-1i5pA:
1.2		 4xi3B-1i5pA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1igw ISOCITRATE LYASE

(Escherichia
coli) 		PF00463
(ICL) 		4 LEU A 229
MET A 175
LEU A 171
HIS A 184
 None
None
None
PYR  A1444 (-4.5A)
 1.37A 4xi3B-1igwA:
0.0		 4xi3B-1igwA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqp DIPEPTIDYL PEPTIDASE
I

(Rattus
norvegicus) 		PF00112
(Peptidase_C1)
PF08773
(CathepsinC_exc) 		4 LEU A 334
GLU A 426
LEU A 206
HIS A 342
 None
 1.37A 4xi3B-1jqpA:
undetectable		 4xi3B-1jqpA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkd BIPHENYL-2,3-DIOL
1,2-DIOXYGENASE

(Paraburkholderia
xenovorans) 		PF00903
(Glyoxalase) 		4 LEU A 197
MET A   9
LEU A  60
HIS A 210
 None
None
None
FE2  A 500 ( 3.5A)
 1.08A 4xi3B-1lkdA:
undetectable		 4xi3B-1lkdA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8y PROTOONCOPROTEIN

(Rattus
norvegicus) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 LEU C 453
GLU C 480
LEU C 472
HIS C 448
 None
 1.29A 4xi3B-1n8yC:
undetectable		 4xi3B-1n8yC:
17.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 346
GLU A 353
MET A 388
LEU A 428
HIS A 524
 EST  A   1 (-4.4A)
EST  A   1 (-2.8A)
None
None
EST  A   1 (-3.8A)
 0.67A 4xi3B-1pcgA:
32.7		 4xi3B-1pcgA:
97.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF16363
(GDP_Man_Dehyd) 		4 LEU A  21
GLU A  77
MET A 233
LEU A 297
 None
 1.27A 4xi3B-1rpnA:
undetectable		 4xi3B-1rpnA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uar RHODANESE

(Thermus
thermophilus) 		PF00581
(Rhodanese) 		4 LEU A   9
GLU A   7
LEU A 257
HIS A 248
 None
 1.36A 4xi3B-1uarA:
undetectable		 4xi3B-1uarA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uwv 23S RRNA
(URACIL-5-)-METHYLTR
ANSFERASE RUMA

(Escherichia
coli) 		PF01938
(TRAM)
PF05958
(tRNA_U5-meth_tr) 		4 LEU A 239
MET A 203
LEU A 230
HIS A 207
 None
 1.31A 4xi3B-1uwvA:
undetectable		 4xi3B-1uwvA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amx ADENOSINE DEAMINASE

(Plasmodium
yoelii) 		PF00962
(A_deaminase) 		4 LEU A 297
GLU A 100
LEU A  60
HIS A 239
 None
None
None
CO  A1000 (-3.4A)
 1.34A 4xi3B-2amxA:
undetectable		 4xi3B-2amxA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atf CYSTEINE DIOXYGENASE
TYPE I

(Mus musculus) 		PF05995
(CDO_I) 		4 LEU A  98
GLU A  46
LEU A  37
HIS A 155
 None
 1.25A 4xi3B-2atfA:
undetectable		 4xi3B-2atfA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox) 		PF00491
(Arginase) 		4 LEU A  36
GLU A  34
MET A  27
LEU A  95
 None
 1.19A 4xi3B-2cevA:
undetectable		 4xi3B-2cevA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Aquifex
aeolicus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A 220
GLU A 218
MET A 212
LEU A 246
 None
 1.31A 4xi3B-2ebdA:
undetectable		 4xi3B-2ebdA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A  48
GLU A  42
LEU A 107
HIS A  23
 None
 1.13A 4xi3B-2eq9A:
undetectable		 4xi3B-2eq9A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 695
GLU A 693
MET A 680
LEU A 629
 None
 1.26A 4xi3B-2f57A:
undetectable		 4xi3B-2f57A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ffs HYPOTHETICAL PROTEIN
PA1206

(Pseudomonas
aeruginosa) 		PF08982
(DUF1857) 		4 LEU A 106
GLU A  99
MET A  96
LEU A  29
 None
 1.30A 4xi3B-2ffsA:
undetectable		 4xi3B-2ffsA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iae SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
56 KDA REGULATORY
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF01603
(B56) 		4 LEU B 275
GLU B 319
LEU B 248
HIS B 255
 None
 1.23A 4xi3B-2iaeB:
undetectable		 4xi3B-2iaeB:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iay HYPOTHETICAL PROTEIN

(Lactobacillus
plantarum) 		PF08866
(DUF1831) 		4 LEU A  46
GLU A  43
MET A  71
LEU A   9
 None
GOL  A 115 (-4.7A)
None
None
 1.30A 4xi3B-2iayA:
undetectable		 4xi3B-2iayA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1

(Saccharomyces
cerevisiae) 		PF03095
(PTPA) 		4 LEU A 142
GLU A 100
LEU A 187
HIS A 148
 None
 1.36A 4xi3B-2ixoA:
undetectable		 4xi3B-2ixoA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 LEU A 256
MET A 238
LEU A 235
HIS A 355
 None
 1.37A 4xi3B-2jgdA:
undetectable		 4xi3B-2jgdA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh9 VP4 CORE PROTEIN

(Bluetongue
virus) 		PF05059
(Orbi_VP4) 		4 LEU A 517
MET A 457
LEU A 568
HIS A 554
 None
 1.26A 4xi3B-2jh9A:
undetectable		 4xi3B-2jh9A:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nsa TRIGGER FACTOR

(Thermotoga
maritima) 		PF05698
(Trigger_C) 		4 LEU A 251
GLU A 277
MET A 271
LEU A 402
 None
 1.29A 4xi3B-2nsaA:
undetectable		 4xi3B-2nsaA:
23.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 346
GLU A 353
MET A 388
LEU A 428
HIS A 524
 EST  A 596 (-4.4A)
EST  A 596 (-2.7A)
None
None
EST  A 596 (-4.2A)
 0.59A 4xi3B-2ocfA:
32.0		 4xi3B-2ocfA:
98.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbx HEMAGGLUTININ/PROTEA
SE REGULATORY
PROTEIN

(Vibrio cholerae) 		PF00440
(TetR_N) 		4 LEU A  80
MET A 101
LEU A 112
HIS A 168
 None
 1.26A 4xi3B-2pbxA:
undetectable		 4xi3B-2pbxA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnl UNCHARACTERIZED
PROTEIN

(Cytophaga
hutchinsonii) 		PF12867
(DinB_2) 		4 LEU A 113
GLU A  65
MET A  60
LEU A 106
 None
 1.25A 4xi3B-2qnlA:
undetectable		 4xi3B-2qnlA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6b L-LACTATE
DEHYDROGENASE

(Deinococcus
radiodurans) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A 287
GLU A 199
LEU A 307
HIS A 304
 None
 1.37A 4xi3B-2v6bA:
undetectable		 4xi3B-2v6bA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vea PHYTOCHROME-LIKE
PROTEIN CPH1

(Synechocystis
sp. PCC 6803) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 LEU A 286
GLU A 306
LEU A 215
HIS A 260
 CYC  A1521 ( 4.9A)
None
None
CYC  A1521 (-3.4A)
 1.12A 4xi3B-2veaA:
undetectable		 4xi3B-2veaA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z00 DIHYDROOROTASE

(Thermus
thermophilus) 		PF01979
(Amidohydro_1) 		4 LEU A 291
GLU A 289
LEU A 336
HIS A 260
 None
 1.32A 4xi3B-2z00A:
undetectable		 4xi3B-2z00A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aux DNA DOUBLE-STRAND
BREAK REPAIR RAD50
ATPASE

(Methanocaldococcus
jannaschii) 		PF13476
(AAA_23) 		4 LEU A 844
GLU A 174
MET A 168
LEU A 851
 None
 1.30A 4xi3B-3auxA:
undetectable		 4xi3B-3auxA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3azq AMINOPEPTIDASE

(Streptomyces
morookaense) 		PF00326
(Peptidase_S9) 		4 LEU A 219
GLU A 248
LEU A 163
HIS A 187
 None
 1.29A 4xi3B-3azqA:
undetectable		 4xi3B-3azqA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz6 UPF0502 PROTEIN
PSPTO_2686

(Pseudomonas
syringae group
genomosp. 3) 		PF04337
(DUF480) 		4 LEU A 126
GLU A 124
LEU A 145
HIS A 133
 None
 1.22A 4xi3B-3bz6A:
undetectable		 4xi3B-3bz6A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3daw TWINFILIN-1

(Mus musculus) 		PF00241
(Cofilin_ADF) 		4 LEU B 279
GLU B 284
LEU B 193
HIS B 237
 None
 1.37A 4xi3B-3dawB:
undetectable		 4xi3B-3dawB:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dgt ENDO-1,3-BETA-GLUCAN
ASE

(Streptomyces
sioyaensis) 		PF00722
(Glyco_hydro_16) 		4 LEU A 126
GLU A 147
MET A 159
HIS A 234
 None
 1.19A 4xi3B-3dgtA:
undetectable		 4xi3B-3dgtA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewd ADENOSINE DEAMINASE

(Plasmodium
vivax) 		PF00962
(A_deaminase) 		4 LEU A 283
GLU A  87
LEU A  47
HIS A 225
 None
None
MCF  A 372 (-4.3A)
ZN  A 371 ( 3.4A)
 1.33A 4xi3B-3ewdA:
undetectable		 4xi3B-3ewdA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN

(Bos taurus) 		PF03055
(RPE65) 		4 LEU A 439
GLU A 469
LEU A  15
HIS A   7
 None
 1.32A 4xi3B-3fsnA:
undetectable		 4xi3B-3fsnA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g33 CCND3 PROTEIN

(Homo sapiens) 		PF00134
(Cyclin_N)
PF02984
(Cyclin_C) 		4 LEU B 186
GLU B  76
LEU B 165
HIS B 181
 None
 1.12A 4xi3B-3g33B:
2.7		 4xi3B-3g33B:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 LEU A 417
GLU A 488
LEU A 423
HIS A 258
 None
 1.34A 4xi3B-3ihvA:
undetectable		 4xi3B-3ihvA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il7 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Staphylococcus
aureus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A 142
MET A 201
LEU A 190
HIS A 238
 None
 1.27A 4xi3B-3il7A:
undetectable		 4xi3B-3il7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3imh GALACTOSE-1-EPIMERAS
E

(Lactobacillus
acidophilus) 		PF01263
(Aldose_epim) 		4 LEU A 165
GLU A 317
LEU A 308
HIS A  88
 None
 1.31A 4xi3B-3imhA:
undetectable		 4xi3B-3imhA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv7 ALCOHOL
DEHYDROGENASE IV

(Corynebacterium
glutamicum) 		PF00465
(Fe-ADH) 		4 LEU A 181
GLU A 278
LEU A 174
HIS A 241
 EDO  A 364 ( 4.3A)
None
None
None
 1.30A 4xi3B-3iv7A:
undetectable		 4xi3B-3iv7A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jap EIF3A

(Saccharomyces
cerevisiae) 		PF00411
(Ribosomal_S11) 		4 GLU o 101
MET o 187
LEU o 202
HIS o 209
 None
 1.21A 4xi3B-3japo:
undetectable		 4xi3B-3japo:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k17 LIN0012 PROTEIN

(Listeria
innocua) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 LEU A  45
GLU A 360
MET A 134
LEU A  91
 None
 1.36A 4xi3B-3k17A:
undetectable		 4xi3B-3k17A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN

(Rhodobacter
sphaeroides) 		PF02126
(PTE) 		4 GLU A 175
MET A  31
LEU A 298
HIS A 231
 ZN  A 401 ( 2.6A)
None
None
None
 1.21A 4xi3B-3k2gA:
undetectable		 4xi3B-3k2gA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl8 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE II

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		4 LEU A 143
GLU A  96
LEU A 205
HIS A 114
 None
 1.36A 4xi3B-3kl8A:
undetectable		 4xi3B-3kl8A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3meb ASPARTATE
AMINOTRANSFERASE

(Giardia
intestinalis) 		PF00155
(Aminotran_1_2) 		4 LEU A 376
MET A 401
LEU A 343
HIS A 363
 None
 1.34A 4xi3B-3mebA:
undetectable		 4xi3B-3mebA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkq COATOMER
BETA'-SUBUNIT

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF04053
(Coatomer_WDAD) 		4 LEU A 307
GLU A 304
MET A 573
LEU A 587
 None
 1.28A 4xi3B-3mkqA:
undetectable		 4xi3B-3mkqA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nre ALDOSE 1-EPIMERASE

(Escherichia
coli) 		PF01263
(Aldose_epim) 		4 LEU A  71
GLU A  68
LEU A 141
HIS A 107
 None
 1.26A 4xi3B-3nreA:
undetectable		 4xi3B-3nreA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5p TAXADIENE SYNTHASE

(Taxus
brevifolia) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 LEU A 407
MET A 414
LEU A 457
HIS A 364
 None
EDO  A 921 (-3.6A)
None
None
 1.36A 4xi3B-3p5pA:
undetectable		 4xi3B-3p5pA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdf DIPEPTIDYL PEPTIDASE
1

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08773
(CathepsinC_exc) 		4 LEU A 335
GLU A 427
LEU A 207
HIS A 343
 None
 1.32A 4xi3B-3pdfA:
undetectable		 4xi3B-3pdfA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7w GTP-BINDING PROTEIN
GTR1

(Saccharomyces
cerevisiae) 		PF04670
(Gtr1_RagA) 		4 LEU A 159
MET A 143
LEU A 125
HIS A  89
 None
 1.37A 4xi3B-3r7wA:
undetectable		 4xi3B-3r7wA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 LEU A 370
GLU A 259
LEU A 449
HIS A 572
 None
 1.33A 4xi3B-3s5kA:
undetectable		 4xi3B-3s5kA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujg SERINE/THREONINE-PRO
TEIN KINASE SRK2E

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 LEU A 156
GLU A 101
LEU A 141
HIS A  74
 None
 1.03A 4xi3B-3ujgA:
undetectable		 4xi3B-3ujgA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcu B1 GLOBIN CHAIN OF
GIANT V2 HEMOGLOBIN

(Lamellibrachia
satsuma) 		PF00042
(Globin) 		4 LEU D 105
MET D 113
LEU D  40
HIS D  67
 HEM  D 201 (-4.6A)
None
None
HEM  D 201 ( 4.6A)
 1.29A 4xi3B-3wcuD:
undetectable		 4xi3B-3wcuD:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wks O-PHOSPHO-L-SERYL-TR
NA:CYS-TRNA SYNTHASE

(Methanocaldococcus
jannaschii) 		PF05889
(SepSecS) 		4 LEU A 245
GLU A 268
MET A 109
LEU A 175
 None
 1.16A 4xi3B-3wksA:
undetectable		 4xi3B-3wksA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7k ALDOS-2-ULOSE
DEHYDRATASE

(Phanerochaete
chrysosporium) 		no annotation 4 LEU A 687
GLU A 674
LEU A 712
HIS A 630
 None
None
None
ZN  A 952 ( 3.3A)
 1.24A 4xi3B-4a7kA:
undetectable		 4xi3B-4a7kA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg5 BBA65

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		4 LEU A  24
GLU A  26
MET A  32
LEU A 137
 None
 1.15A 4xi3B-4bg5A:
undetectable		 4xi3B-4bg5A:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE

(Salmonella
enterica) 		PF01909
(NTP_transf_2)
PF13427
(DUF4111) 		4 LEU A 139
MET A 131
LEU A  96
HIS A  32
 None
 1.07A 4xi3B-4cs6A:
undetectable		 4xi3B-4cs6A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyo ASPARTYL
AMINOPEPTIDASE

(Homo sapiens) 		PF02127
(Peptidase_M18) 		4 LEU A 240
GLU A 237
LEU A 228
HIS A  33
 None
 1.35A 4xi3B-4dyoA:
undetectable		 4xi3B-4dyoA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g59 M152 PROTEIN
RETINOIC ACID
EARLY-INDUCIBLE
PROTEIN 1-GAMMA

(Murid
betaherpesvirus
1;
Mus musculus) 		PF11624
(M157)
PF14586
(MHC_I_2) 		4 LEU A  20
GLU C  28
LEU A   9
HIS A  91
 None
 1.17A 4xi3B-4g59A:
1.6		 4xi3B-4g59A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 983
GLU A 985
LEU A 902
HIS A 974
 IZA  A2001 ( 4.7A)
None
None
None
 1.13A 4xi3B-4gl9A:
undetectable		 4xi3B-4gl9A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Metarhizium
anisopliae) 		PF04909
(Amidohydro_2) 		4 LEU A  44
GLU A  25
LEU A  96
HIS A 197
 None
 1.24A 4xi3B-4hjwA:
undetectable		 4xi3B-4hjwA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpp PROBABLE GLUTAMINE
SYNTHETASE

(Pseudomonas
aeruginosa) 		PF00120
(Gln-synt_C)
PF16952
(Gln-synt_N_2) 		4 LEU A  96
GLU A  98
LEU A 412
HIS A 343
 None
 1.35A 4xi3B-4hppA:
undetectable		 4xi3B-4hppA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 956
GLU A 958
LEU A 875
HIS A 947
 19S  A1201 (-4.5A)
None
None
None
 1.25A 4xi3B-4hviA:
undetectable		 4xi3B-4hviA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjj CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Thermobifida
fusca) 		PF02011
(Glyco_hydro_48) 		4 GLU A  40
MET A  37
LEU A 596
HIS A 603
 CBK  A 702 ( 3.4A)
None
None
ZN  A 716 (-3.2A)
 1.30A 4xi3B-4jjjA:
undetectable		 4xi3B-4jjjA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 144
GLU A  96
LEU A 204
HIS A 115
 None
 1.33A 4xi3B-4jxfA:
undetectable		 4xi3B-4jxfA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 653
GLU A 651
MET A 638
LEU A 587
 None
 1.29A 4xi3B-4ks8A:
undetectable		 4xi3B-4ks8A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgv GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE

(Mycobacterium
avium) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 LEU A 110
GLU A 114
LEU A  33
HIS A  41
 None
 1.33A 4xi3B-4lgvA:
undetectable		 4xi3B-4lgvA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis) 		PF02222
(ATP-grasp) 		4 GLU A 363
MET A 309
LEU A 315
HIS A 324
 None
 1.35A 4xi3B-4ma5A:
undetectable		 4xi3B-4ma5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ma5 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Francisella
tularensis) 		PF02222
(ATP-grasp) 		4 LEU A 303
GLU A 363
MET A 309
LEU A 315
 None
 1.34A 4xi3B-4ma5A:
undetectable		 4xi3B-4ma5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nrh COPN

(Chlamydia
pneumoniae) 		PF07201
(HrpJ) 		4 LEU A 208
MET A 244
LEU A 260
HIS A 215
 None
 1.28A 4xi3B-4nrhA:
2.5		 4xi3B-4nrhA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0a E3 UBIQUITIN-PROTEIN
LIGASE RNF31

(Homo sapiens) 		PF09409
(PUB) 		4 LEU A 155
GLU A  80
LEU A  31
HIS A 168
 None
 0.80A 4xi3B-4p0aA:
undetectable		 4xi3B-4p0aA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdx PUTATIVE
ALKYL/ARYL-SULFATASE
YJCS

(Escherichia
coli) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 LEU A 351
GLU A 349
LEU A 341
HIS A 297
 None
 1.36A 4xi3B-4pdxA:
undetectable		 4xi3B-4pdxA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		4 LEU A 202
GLU A 200
MET A 194
LEU A 129
 None
 1.35A 4xi3B-4q2cA:
undetectable		 4xi3B-4q2cA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvj VP1

(Norwalk virus) 		PF08435
(Calici_coat_C) 		4 GLU A 530
MET A 533
LEU A 511
HIS A 496
 None
 1.31A 4xi3B-4qvjA:
undetectable		 4xi3B-4qvjA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		4 LEU A 221
GLU A 225
LEU A 283
HIS A 140
 None
 1.18A 4xi3B-4xz5A:
undetectable		 4xi3B-4xz5A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 LEU A1100
GLU A1171
LEU A1145
HIS A1184
 None
 1.34A 4xi3B-5a31A:
undetectable		 4xi3B-5a31A:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a60 INORGANIC
TRIPHOSPHATASE

(Escherichia
coli) 		PF01928
(CYTH) 		4 LEU A 255
GLU A 240
LEU A 284
HIS A 263
 None
 0.98A 4xi3B-5a60A:
undetectable		 4xi3B-5a60A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d68 KREV INTERACTION
TRAPPED PROTEIN 1

(Homo sapiens) 		PF00373
(FERM_M)
PF13857
(Ank_5) 		4 LEU A 340
GLU A 335
LEU A 374
HIS A 326
 None
 1.35A 4xi3B-5d68A:
undetectable		 4xi3B-5d68A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 4 LEU B1081
GLU B1034
LEU B1010
HIS B1052
 None
 1.36A 4xi3B-5dlqB:
undetectable		 4xi3B-5dlqB:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Vibrio cholerae) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		4 LEU A 171
GLU A 169
LEU A 210
HIS A 181
 None
 1.20A 4xi3B-5dt9A:
undetectable		 4xi3B-5dt9A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dvj BINDING PROTEIN
COMPONENT OF ABC
SUGAR TRANSPORTER

(Pseudomonas
putida) 		PF01547
(SBP_bac_1) 		4 LEU A 373
GLU A 366
LEU A 202
HIS A 211
 None
 1.00A 4xi3B-5dvjA:
undetectable		 4xi3B-5dvjA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 897
GLU A 925
MET A 978
LEU A 976
 None
None
5U3  A1200 ( 4.0A)
None
 1.13A 4xi3B-5f1zA:
undetectable		 4xi3B-5f1zA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2v N-ACETYLGLUCOSAMINE-
6-SULFATASE

(Bacteroides
thetaiotaomicron) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		4 LEU A 320
MET A 312
LEU A  51
HIS A  39
 None
 1.28A 4xi3B-5g2vA:
undetectable		 4xi3B-5g2vA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idn CYCLIN-DEPENDENT
KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 158
GLU A 165
LEU A  70
HIS A 149
 6A7  A 401 (-4.8A)
None
None
FMT  A 403 (-4.6A)
 0.96A 4xi3B-5idnA:
undetectable		 4xi3B-5idnA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j04 ENOLASE

(Synechococcus
elongatus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LEU A 116
GLU A 348
LEU A 380
HIS A 124
 None
 1.36A 4xi3B-5j04A:
undetectable		 4xi3B-5j04A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j47 LARGE T ANTIGEN

(Human
polyomavirus 2) 		PF06431
(Polyoma_lg_T_C) 		4 LEU A 410
GLU A 408
MET A 402
LEU A 579
 None
 1.26A 4xi3B-5j47A:
undetectable		 4xi3B-5j47A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9n POLYAMINE N
ACETYLTRANSFERASE

(Drosophila
melanogaster) 		PF00583
(Acetyltransf_1) 		4 LEU A  53
GLU A  51
LEU A 104
HIS A 127
 None
 1.19A 4xi3B-5k9nA:
undetectable		 4xi3B-5k9nA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0o RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP1

(Homo sapiens) 		PF00307
(CH) 		4 LEU A  68
GLU A  70
LEU A  78
HIS A 153
 None
 1.30A 4xi3B-5l0oA:
undetectable		 4xi3B-5l0oA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o4g RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		no annotation 4 LEU C 452
GLU C 479
LEU C 471
HIS C 447
 None
 1.26A 4xi3B-5o4gC:
undetectable		 4xi3B-5o4gC:
13.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 298
GLU A 305
MET A 340
LEU A 380
HIS A 475
 EST  A 601 (-4.1A)
EST  A 601 (-2.4A)
EST  A 601 ( 4.8A)
None
EST  A 601 (-4.4A)
 0.65A 4xi3B-5toaA:
30.4		 4xi3B-5toaA:
59.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xly CHEMOTAXIS PROTEIN
METHYLTRANSFERASE 1

(Pseudomonas
aeruginosa) 		PF01739
(CheR)
PF03705
(CheR_N) 		4 LEU A  61
GLU A  63
MET A  69
LEU A  35
 None
 1.15A 4xi3B-5xlyA:
undetectable		 4xi3B-5xlyA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 LEU B 707
GLU B 742
MET B 699
HIS B 735
 None
 1.35A 4xi3B-5xogB:
undetectable		 4xi3B-5xogB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yz0 SERINE/THREONINE-PRO
TEIN KINASE ATR

(Homo sapiens) 		no annotation 4 LEU A2145
GLU A2340
LEU A2093
HIS A2151
 None
 1.15A 4xi3B-5yz0A:
undetectable		 4xi3B-5yz0A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqh LYSINE--TRNA LIGASE

(Mycolicibacterium
thermoresistibile) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 LEU A 292
GLU A 299
MET A 186
LEU A 253
 None
 1.03A 4xi3B-6aqhA:
undetectable		 4xi3B-6aqhA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 4 LEU A1010
GLU A1012
LEU A 929
HIS A1001
 ADP  A1201 (-4.5A)
None
None
None
 1.16A 4xi3B-6c7yA:
undetectable		 4xi3B-6c7yA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnu METHYLENETETRAHYDROF
OLATE REDUCTASE 1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A  17
GLU A 291
MET A  32
LEU A  71
 None
 1.14A 4xi3B-6fnuA:
undetectable		 4xi3B-6fnuA:
15.52