SIMILAR PATTERNS OF AMINO ACIDS FOR 4XEY_A_1N1A601_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ea9 | CYCLOMALTODEXTRINASE (Bacillus sp.(in: Bacteria)) |
PF00128(Alpha-amylase)PF02903(Alpha-amylase_N)PF16657(Malt_amylase_C) | 3 | MET C 372ASP C 238PHE C 191 | None | 1.04A | 4xeyA-1ea9C:undetectable | 4xeyA-1ea9C:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fez | PHOSPHONOACETALDEHYDE HYDROLASE (Bacillus cereus) |
PF13419(HAD_2) | 3 | MET A 165ASP A 12PHE A 11 | None MG A 801 (-3.7A)None | 0.98A | 4xeyA-1fezA:undetectable | 4xeyA-1fezA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k7s | FERRICHROME-BINDINGPERIPLASMIC PROTEIN (Escherichiacoli) |
PF01497(Peripla_BP_2) | 3 | MET N 250ASP N 239PHE N 238 | None | 1.06A | 4xeyA-1k7sN:0.0 | 4xeyA-1k7sN:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lqt | FPRA (Mycobacteriumtuberculosis) |
PF07992(Pyr_redox_2) | 3 | MET A 111ASP A 127PHE A 128 | None | 0.90A | 4xeyA-1lqtA:0.0 | 4xeyA-1lqtA:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mh6 | BLEOMYCIN RESISTANCEPROTEIN (Klebsiellapneumoniae) |
no annotation | 3 | MET A 236ASP A 310PHE A 260 | None | 0.90A | 4xeyA-1mh6A:0.1 | 4xeyA-1mh6A:14.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mi5 | TCR ALPHA CHAIN (Homo sapiens) |
PF07686(V-set)PF09291(DUF1968) | 3 | MET D 168ASP D 143PHE D 144 | None | 1.07A | 4xeyA-1mi5D:0.5 | 4xeyA-1mi5D:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1okc | ADP, ATP CARRIERPROTEIN HEARTISOFORM T1 (Bos taurus) |
PF00153(Mito_carr) | 3 | MET A 238ASP A 231PHE A 230 | NoneCXT A 401 (-3.6A)LDM A 904 ( 4.7A) | 1.06A | 4xeyA-1okcA:undetectable | 4xeyA-1okcA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qq6 | PROTEIN(L-2-HALOACIDDEHALOGENASE) (Xanthobacterautotrophicus) |
PF00702(Hydrolase) | 3 | MET A 218ASP A 15PHE A 14 | None | 0.82A | 4xeyA-1qq6A:0.0 | 4xeyA-1qq6A:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s5t | DIHYDRODIPICOLINATESYNTHASE (Escherichiacoli) |
PF00701(DHDPS) | 3 | MET A 237ASP A 193PHE A 194 | None | 1.05A | 4xeyA-1s5tA:0.0 | 4xeyA-1s5tA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tq4 | INTERFERON-INDUCIBLEGTPASE (Mus musculus) |
PF05049(IIGP) | 3 | MET A 144ASP A 126PHE A 124 | None MG A 501 (-2.8A)None | 1.01A | 4xeyA-1tq4A:0.0 | 4xeyA-1tq4A:22.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vzo | RIBOSOMAL PROTEIN S6KINASE ALPHA 5 (Homo sapiens) |
PF00069(Pkinase) | 3 | MET A 295ASP A 288PHE A 317 | None | 0.96A | 4xeyA-1vzoA:19.8 | 4xeyA-1vzoA:24.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ylo | HYPOTHETICAL PROTEINSF2450 (Shigellaflexneri) |
PF05343(Peptidase_M42) | 3 | MET A 58ASP A 40PHE A 39 | None | 1.06A | 4xeyA-1yloA:undetectable | 4xeyA-1yloA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ebn | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE F1 (Elizabethkingiameningoseptica) |
PF00704(Glyco_hydro_18) | 3 | MET A 247ASP A 130PHE A 129 | None | 0.99A | 4xeyA-2ebnA:undetectable | 4xeyA-2ebnA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f1z | UBIQUITINCARBOXYL-TERMINALHYDROLASE 7 (Homo sapiens) |
PF00443(UCH)PF00917(MATH) | 3 | MET A 328ASP A 349PHE A 324 | None | 1.02A | 4xeyA-2f1zA:undetectable | 4xeyA-2f1zA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g3n | ALPHA-GLUCOSIDASE (Sulfolobussolfataricus) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 3 | MET A 321ASP A 212PHE A 210 | BOG A2000 ( 4.0A)NoneNone | 1.06A | 4xeyA-2g3nA:1.3 | 4xeyA-2g3nA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gsj | PROTEIN PPL-2 (Parkiaplatycephala) |
PF00704(Glyco_hydro_18) | 3 | MET A 251ASP A 125PHE A 124 | None | 0.89A | 4xeyA-2gsjA:undetectable | 4xeyA-2gsjA:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hi0 | PUTATIVEPHOSPHOGLYCOLATEPHOSPHATASE (Lactobacillusdelbrueckii) |
PF13419(HAD_2) | 3 | MET A 169ASP A 9PHE A 8 | None NA A 240 (-2.9A)None | 0.95A | 4xeyA-2hi0A:undetectable | 4xeyA-2hi0A:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hjj | HYPOTHETICAL PROTEINYKFF (Escherichiacoli) |
PF06006(DUF905) | 3 | MET A 48ASP A 31PHE A 37 | None | 1.00A | 4xeyA-2hjjA:undetectable | 4xeyA-2hjjA:11.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2l9w | U4/U6SNRNA-ASSOCIATED-SPLICING FACTOR PRP24 (Saccharomycescerevisiae) |
PF16842(RRM_occluded) | 3 | MET A 370ASP A 389PHE A 317 | None | 1.07A | 4xeyA-2l9wA:undetectable | 4xeyA-2l9wA:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ldy | ORF1 CODES FOR A 40KDA PRODUCT (Homo sapiens) |
PF02994(Transposase_22)PF17490(Tnp_22_dsRBD) | 3 | MET A 323ASP A 305PHE A 306 | None | 0.92A | 4xeyA-2ldyA:undetectable | 4xeyA-2ldyA:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mzb | ADENOSYLCOBINAMIDE-PHOSPHATEGUANYLYLTRANSFERASE (Methanocaldococcusjannaschii) |
PF12804(NTP_transf_3) | 3 | MET A 14ASP A 183PHE A 176 | None | 0.94A | 4xeyA-2mzbA:undetectable | 4xeyA-2mzbA:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o3l | HYPOTHETICAL PROTEIN (Bacillus cereus) |
PF06304(DUF1048) | 3 | MET A 17ASP A 60PHE A 62 | None | 0.83A | 4xeyA-2o3lA:undetectable | 4xeyA-2o3lA:10.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2obb | HYPOTHETICAL PROTEIN (Bacteroidesthetaiotaomicron) |
no annotation | 3 | MET A 109ASP A 102PHE A 25 | None | 1.04A | 4xeyA-2obbA:undetectable | 4xeyA-2obbA:16.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ozk | URIDYLATE-SPECIFICENDORIBONUCLEASE (Severe acuterespiratorysyndrome-relatedcoronavirus) |
PF06471(NSP11) | 3 | MET A 251ASP A 267PHE A 268 | None | 1.04A | 4xeyA-2ozkA:undetectable | 4xeyA-2ozkA:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p0r | CALPAIN-9 (Homo sapiens) |
PF00648(Peptidase_C2) | 3 | MET A 32ASP A 47PHE A 48 | None | 1.05A | 4xeyA-2p0rA:undetectable | 4xeyA-2p0rA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p3x | POLYPHENOL OXIDASE,CHLOROPLAST (Vitis vinifera) |
PF00264(Tyrosinase)PF12142(PPO1_DWL) | 3 | MET A 152ASP A 265PHE A 268 | NoneNoneC2O A 340 ( 4.7A) | 0.92A | 4xeyA-2p3xA:undetectable | 4xeyA-2p3xA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v5q | DESIGN ANKYRINREPEAT PROTEIN (unidentified) |
PF12796(Ank_2)PF13637(Ank_4) | 3 | MET C 89ASP C 110PHE C 109 | None | 0.99A | 4xeyA-2v5qC:undetectable | 4xeyA-2v5qC:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vvt | GLUTAMATE RACEMASE (Enterococcusfaecalis) |
PF01177(Asp_Glu_race) | 3 | MET A 1ASP A 224PHE A 223 | None | 1.05A | 4xeyA-2vvtA:undetectable | 4xeyA-2vvtA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xvn | ASPERGILLUSFUMIGATUS CHITINASEA1 (Aspergillusfumigatus) |
PF00704(Glyco_hydro_18) | 3 | MET A 310ASP A 172PHE A 171 | KLS A1338 ( 4.9A)KLS A1338 (-2.8A)None | 0.88A | 4xeyA-2xvnA:undetectable | 4xeyA-2xvnA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ybu | ACIDIC MAMMALIANCHITINASE (Homo sapiens) |
PF00704(Glyco_hydro_18) | 3 | MET A 358ASP A 138PHE A 137 | NoneCX9 A1398 (-3.0A)None | 0.84A | 4xeyA-2ybuA:undetectable | 4xeyA-2ybuA:22.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zfu | CEREBRAL PROTEIN 1 (Homo sapiens) |
PF05148(Methyltransf_8) | 3 | MET A 367ASP A 334PHE A 333 | SAH A 900 ( 3.7A)SAH A 900 (-2.7A)None | 0.72A | 4xeyA-2zfuA:undetectable | 4xeyA-2zfuA:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zxq | ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE (Bifidobacteriumlongum) |
PF12905(Glyco_hydro_101)PF17451(Glyco_hyd_101C) | 3 | MET A1102ASP A1248PHE A1247 | None MN A 3 (-2.2A)None | 1.04A | 4xeyA-2zxqA:0.0 | 4xeyA-2zxqA:15.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zzw | ABC TRANSPORTER,SOLUTE-BINDINGPROTEIN (Thermusthermophilus) |
PF03480(DctP) | 3 | MET A 106ASP A 253PHE A 98 | NoneNoneLAC A 401 (-4.0A) | 0.97A | 4xeyA-2zzwA:undetectable | 4xeyA-2zzwA:23.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cb5 | FACT COMPLEX SUBUNITSPT16 (Schizosaccharomycespombe) |
PF00557(Peptidase_M24)PF14826(FACT-Spt16_Nlob) | 3 | MET A 195ASP A 413PHE A 425 | None | 1.05A | 4xeyA-3cb5A:undetectable | 4xeyA-3cb5A:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cq5 | HISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Corynebacteriumglutamicum) |
PF00155(Aminotran_1_2) | 3 | MET A 150ASP A 176PHE A 146 | None | 0.92A | 4xeyA-3cq5A:undetectable | 4xeyA-3cq5A:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3edl | KINESIN13 MOTORDOMAIN (Drosophilamelanogaster) |
PF00225(Kinesin) | 3 | MET D 265ASP D 225PHE D 224 | None | 1.05A | 4xeyA-3edlD:undetectable | 4xeyA-3edlD:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f7s | UNCHARACTERIZEDNTF2-LIKE PROTEIN (Pseudomonasputida) |
PF13474(SnoaL_3) | 3 | MET A 104ASP A 40PHE A 39 | UNL A 142 ( 4.9A)UNL A 142 (-3.1A)None | 1.06A | 4xeyA-3f7sA:undetectable | 4xeyA-3f7sA:16.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gw4 | UNCHARACTERIZEDPROTEIN (Deinococcusradiodurans) |
PF13424(TPR_12) | 3 | MET A 191ASP A 176PHE A 151 | None | 1.04A | 4xeyA-3gw4A:undetectable | 4xeyA-3gw4A:20.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h4q | PUTATIVEACETYLTRANSFERASE (Staphylococcusaureus) |
PF00583(Acetyltransf_1) | 3 | MET A 1ASP A 9PHE A 63 | None | 0.90A | 4xeyA-3h4qA:undetectable | 4xeyA-3h4qA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h9c | METHIONYL-TRNASYNTHETASE (Escherichiacoli) |
PF09334(tRNA-synt_1g) | 3 | MET A 184ASP A 138PHE A 140 | None | 0.75A | 4xeyA-3h9cA:undetectable | 4xeyA-3h9cA:21.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hjz | TRANSALDOLASE B (Prochlorococcusmarinus) |
PF00923(TAL_FSA) | 3 | MET A 226ASP A 17PHE A 251 | None | 0.98A | 4xeyA-3hjzA:undetectable | 4xeyA-3hjzA:24.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i1c | DIISOPROPYL-FLUOROPHOSPHATASE (Loligo vulgaris) |
PF08450(SGL) | 3 | MET A 261ASP A 234PHE A 233 | None | 1.02A | 4xeyA-3i1cA:undetectable | 4xeyA-3i1cA:21.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ihk | THIAMINPYROPHOSPHOKINASE (Streptococcusmutans) |
PF04263(TPK_catalytic)PF04265(TPK_B1_binding) | 3 | MET A 105ASP A 128PHE A 95 | None | 1.06A | 4xeyA-3ihkA:undetectable | 4xeyA-3ihkA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iru | PHOSHONOACETALDEHYDEHYDROLASE LIKEPROTEIN (Oleispiraantarctica) |
PF13419(HAD_2) | 3 | MET A 55ASP A 25PHE A 26 | None | 1.03A | 4xeyA-3iruA:undetectable | 4xeyA-3iruA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kyd | SUMO-ACTIVATINGENZYME SUBUNIT 1 (Homo sapiens) |
PF00899(ThiF) | 3 | MET A 299ASP A 332PHE A 330 | None | 1.07A | 4xeyA-3kydA:undetectable | 4xeyA-3kydA:22.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l7i | TEICHOIC ACIDBIOSYNTHESIS PROTEINF (Staphylococcusepidermidis) |
PF04464(Glyphos_transf) | 3 | MET A 460ASP A 549PHE A 552 | None | 0.94A | 4xeyA-3l7iA:undetectable | 4xeyA-3l7iA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lg3 | ISOCITRATE LYASE (Yersinia pestis) |
PF00463(ICL) | 3 | MET A 199ASP A 257PHE A 264 | None | 1.03A | 4xeyA-3lg3A:undetectable | 4xeyA-3lg3A:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m0o | MONOMERIC SARCOSINEOXIDASE (Bacillus sp.B-0618) |
PF01266(DAO) | 3 | MET A 16ASP A 36PHE A 35 | NoneNoneFAD A 400 (-4.7A) | 1.00A | 4xeyA-3m0oA:undetectable | 4xeyA-3m0oA:24.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mlx | HUMAN MONOCLONALANTI-HIV-1 GP120 V3ANTIBODY 3074 FABHEAVY CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 3 | MET H 69ASP H 95PHE H 32 | None | 0.97A | 4xeyA-3mlxH:undetectable | 4xeyA-3mlxH:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n0a | TYROSINE-PROTEINPHOSPHATASE AUXILIN (Bos taurus) |
PF10409(PTEN_C2) | 3 | MET A 212ASP A 292PHE A 322 | None | 0.78A | 4xeyA-3n0aA:undetectable | 4xeyA-3n0aA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n5f | N-CARBAMOYL-L-AMINOACID HYDROLASE (Geobacillusstearothermophilus) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 3 | MET A 369ASP A 90PHE A 89 | None CO A 410 (-2.8A)None | 0.92A | 4xeyA-3n5fA:undetectable | 4xeyA-3n5fA:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q3u | LIGNIN PEROXIDASE (Trametopsiscervina) |
PF00141(peroxidase)PF11895(Peroxidase_ext) | 3 | MET A 259ASP A 193PHE A 192 | None CA A 341 (-2.2A)HEM A 338 (-4.8A) | 1.05A | 4xeyA-3q3uA:undetectable | 4xeyA-3q3uA:19.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qty | PHOSPHORIBOSYLAMINOIMIDAZOLE (AIR)SYNTHETASE (Francisellatularensis) |
PF00586(AIRS)PF02769(AIRS_C) | 3 | MET A 23ASP A 107PHE A 88 | POP A 404 ( 3.9A)POP A 404 (-2.6A)None | 1.01A | 4xeyA-3qtyA:undetectable | 4xeyA-3qtyA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s7w | EIGHT-HEME NITRITEREDUCTASE (Thioalkalivibrionitratireducens) |
PF02335(Cytochrom_C552) | 3 | MET A 99ASP A 450PHE A 452 | None | 0.95A | 4xeyA-3s7wA:undetectable | 4xeyA-3s7wA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ssz | MANDELATERACEMASE/MUCONATELACTONIZING ENZYME,N-TERMINAL DOMAINPROTEIN (Rhodobacteraceaebacterium KLH11) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | MET A 343ASP A 389PHE A 387 | None | 1.00A | 4xeyA-3sszA:undetectable | 4xeyA-3sszA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ut3 | PLASMINOGENACTIVATOR INHIBITOR1 (Homo sapiens) |
PF00079(Serpin) | 3 | MET A 83ASP A 95PHE A 117 | None | 0.80A | 4xeyA-3ut3A:undetectable | 4xeyA-3ut3A:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vfd | SPASTIN (Homo sapiens) |
PF00004(AAA)PF09336(Vps4_C) | 3 | MET A 390ASP A 334PHE A 404 | None | 1.01A | 4xeyA-3vfdA:undetectable | 4xeyA-3vfdA:23.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a0l | CULLIN-4B (Homo sapiens) |
PF00888(Cullin)PF10557(Cullin_Nedd8) | 3 | MET E 586ASP E 521PHE E 522 | None | 0.94A | 4xeyA-4a0lE:undetectable | 4xeyA-4a0lE:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g7e | UREASE (Cajanus cajan) |
PF00449(Urease_alpha)PF00547(Urease_gamma)PF00699(Urease_beta)PF01979(Amidohydro_1) | 3 | MET B 376ASP B 356PHE B 306 | None | 1.06A | 4xeyA-4g7eB:undetectable | 4xeyA-4g7eB:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gwn | MEPRIN A SUBUNITBETA (Homo sapiens) |
PF00629(MAM)PF01400(Astacin) | 3 | MET A 302ASP A 578PHE A 437 | None | 1.00A | 4xeyA-4gwnA:undetectable | 4xeyA-4gwnA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lq0 | LAGLIDADG HOMINGENDONUCLEASE (Leptographiumtruncatum) |
PF00961(LAGLIDADG_1) | 3 | MET A 277ASP A 270PHE A 184 | None | 1.07A | 4xeyA-4lq0A:0.0 | 4xeyA-4lq0A:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mup | AMIDOHYDROLASE (Agrobacteriumfabrum) |
PF04909(Amidohydro_2) | 3 | MET A 145ASP A 172PHE A 171 | None | 0.95A | 4xeyA-4mupA:undetectable | 4xeyA-4mupA:22.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4my5 | PUTATIVE AMINO ACIDAMINOTRANSFERASE (Streptococcusmutans) |
PF00155(Aminotran_1_2) | 3 | MET A 18ASP A 334PHE A 338 | None | 0.75A | 4xeyA-4my5A:undetectable | 4xeyA-4my5A:24.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ny4 | CYTOCHROME P450 3A4 (Homo sapiens) |
PF00067(p450) | 3 | MET A 371ASP A 214PHE A 213 | NoneNone2QH A 602 (-4.2A) | 0.98A | 4xeyA-4ny4A:undetectable | 4xeyA-4ny4A:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4toq | CLASS III CHITINASE (Punica granatum) |
PF00704(Glyco_hydro_18) | 3 | MET A 255ASP A 125PHE A 124 | None | 0.88A | 4xeyA-4toqA:undetectable | 4xeyA-4toqA:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u14 | MUSCARINICACETYLCHOLINERECEPTORM3,ENDOLYSIN,MUSCARINIC ACETYLCHOLINERECEPTOR M3 (Escherichiavirus T4;Rattusnorvegicus) |
PF00001(7tm_1)PF00959(Phage_lysozyme) | 3 | MET A1001ASP A 164PHE A 163 | None | 1.00A | 4xeyA-4u14A:undetectable | 4xeyA-4u14A:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wgx | MOLINATE HYDROLASE (Gulosibactermolinativorax) |
PF01979(Amidohydro_1) | 3 | MET A 155ASP A 174PHE A 177 | None | 0.95A | 4xeyA-4wgxA:undetectable | 4xeyA-4wgxA:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wl2 | PUTATIVE EXPORTEDCHOLOYLGLYCINEHYDROLASE (Pectobacteriumatrosepticum) |
PF02275(CBAH) | 3 | MET A 205ASP A 214PHE A 216 | None | 1.04A | 4xeyA-4wl2A:undetectable | 4xeyA-4wl2A:24.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xdi | CHLAMYDOMONASREINHARDTII THB1 (Chlamydomonasreinhardtii) |
PF01152(Bac_globin) | 3 | MET A 47ASP A 26PHE A 28 | None | 1.07A | 4xeyA-4xdiA:undetectable | 4xeyA-4xdiA:15.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xj5 | CYCLIC AMP-GMPSYNTHASE (Vibrio cholerae) |
no annotation | 3 | MET A 19ASP A 118PHE A 115 | NoneEDO A1008 (-3.7A)EDO A1008 (-4.2A) | 1.04A | 4xeyA-4xj5A:undetectable | 4xeyA-4xj5A:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xpd | N-TERMINALACETYLTRANSFERASE ACOMPLEX SUBUNIT NAT1 (Saccharomycescerevisiae) |
PF12569(NARP1) | 3 | MET A 751ASP A 717PHE A 720 | None | 0.97A | 4xeyA-4xpdA:undetectable | 4xeyA-4xpdA:17.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y05 | KINESIN-LIKE PROTEINKIF2C (Homo sapiens) |
PF00225(Kinesin) | 3 | MET A 451ASP A 411PHE A 402 | None | 1.02A | 4xeyA-4y05A:undetectable | 4xeyA-4y05A:24.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y05 | KINESIN-LIKE PROTEINKIF2C (Homo sapiens) |
PF00225(Kinesin) | 3 | MET A 451ASP A 411PHE A 410 | None | 1.07A | 4xeyA-4y05A:undetectable | 4xeyA-4y05A:24.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e24 | SUPPRESSOR OFHAIRLESS PROTEIN (Drosophilamelanogaster) |
PF09270(BTD)PF09271(LAG1-DNAbind) | 3 | MET E 110ASP E 119PHE E 414 | None | 1.06A | 4xeyA-5e24E:undetectable | 4xeyA-5e24E:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fku | DNA POLYMERASE IIISUBUNIT ALPHA (Escherichiacoli) |
PF01336(tRNA_anti-codon)PF02811(PHP)PF07733(DNA_pol3_alpha)PF14579(HHH_6) | 3 | MET A 469ASP A1058PHE A1059 | None | 1.04A | 4xeyA-5fkuA:undetectable | 4xeyA-5fkuA:15.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h3x | FIBRONECTIN/FIBRINOGEN BINDING PROTEIN (Streptococcussuis) |
PF05833(FbpA) | 3 | MET A 11ASP A 262PHE A 263 | None | 1.03A | 4xeyA-5h3xA:undetectable | 4xeyA-5h3xA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hyd | PROTEIN S100-Z (Homo sapiens) |
PF01023(S_100) | 3 | MET A 78ASP A 71PHE A 27 | None | 0.78A | 4xeyA-5hydA:undetectable | 4xeyA-5hydA:13.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j9r | CHOLOYLGLYCINEHYDROLASE (Agrobacteriumtumefaciens) |
PF02275(CBAH) | 3 | MET A 196ASP A 205PHE A 207 | None | 1.06A | 4xeyA-5j9rA:undetectable | 4xeyA-5j9rA:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jqk | PEPTIDASE, PUTATIVE (Plasmodiumfalciparum) |
PF00557(Peptidase_M24)PF01321(Creatinase_N)PF16188(Peptidase_M24_C)PF16189(Creatinase_N_2) | 3 | MET A 714ASP A 710PHE A 709 | None | 0.95A | 4xeyA-5jqkA:undetectable | 4xeyA-5jqkA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k9t | PROTEIN TRANSLOCASESUBUNIT SECA (Escherichiacoli) |
PF01043(SecA_PP_bind)PF07517(SecA_DEAD) | 3 | MET A 92ASP A 85PHE A 84 | NoneNoneADP A 901 (-3.4A) | 1.00A | 4xeyA-5k9tA:undetectable | 4xeyA-5k9tA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m8h | ATPPHOSPHORIBOSYLTRANSFERASE REGULATORYSUBUNIT (Psychrobacterarcticus) |
PF13393(tRNA-synt_His) | 3 | MET A 367ASP A 329PHE A 333 | None | 1.02A | 4xeyA-5m8hA:1.0 | 4xeyA-5m8hA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5men | PROTEIN TRAV22,HUMANNKT TCR ALPHA CHAIN (Homo sapiens) |
PF07686(V-set)PF09291(DUF1968) | 3 | MET D 163ASP D 138PHE D 139 | None | 0.99A | 4xeyA-5menD:undetectable | 4xeyA-5menD:19.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mio | KINESIN-LIKE PROTEINKIF2C,KIF2C FUSED TOA DARPIN,KIF2C FUSEDTO A DARPIN (Homo sapiens) |
PF00023(Ank)PF00225(Kinesin)PF12796(Ank_2) | 3 | MET C 451ASP C 411PHE C 402 | None | 0.93A | 4xeyA-5mioC:undetectable | 4xeyA-5mioC:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mio | KINESIN-LIKE PROTEINKIF2C,KIF2C FUSED TOA DARPIN,KIF2C FUSEDTO A DARPIN (Homo sapiens) |
PF00023(Ank)PF00225(Kinesin)PF12796(Ank_2) | 3 | MET C 451ASP C 411PHE C 410 | None | 1.02A | 4xeyA-5mioC:undetectable | 4xeyA-5mioC:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mju | EXCITATORY AMINOACID TRANSPORTER1,NEUTRAL AMINO ACIDTRANSPORTERB(0),EXCITATORYAMINO ACIDTRANSPORTER 1 (Homo sapiens) |
PF00375(SDF) | 3 | MET A 379ASP A 456PHE A 458 | 7O9 A 602 (-4.3A)7O9 A 602 (-3.5A)None | 1.07A | 4xeyA-5mjuA:undetectable | 4xeyA-5mjuA:22.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n4l | CERULOPLASMIN (Rattusnorvegicus) |
no annotation | 3 | MET A 728ASP A 744PHE A 742 | None | 0.86A | 4xeyA-5n4lA:undetectable | 4xeyA-5n4lA:12.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5of4 | TFIIH BASALTRANSCRIPTION FACTORCOMPLEX HELICASE XPDSUBUNIT (Homo sapiens) |
PF06733(DEAD_2)PF06777(HBB)PF13307(Helicase_C_2) | 3 | MET B 657ASP B 681PHE B 621 | None | 1.07A | 4xeyA-5of4B:undetectable | 4xeyA-5of4B:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ojs | TRANSCRIPTION-ASSOCIATED PROTEIN 1 (Saccharomycescerevisiae) |
PF00454(PI3_PI4_kinase)PF02259(FAT) | 3 | MET T3489ASP T3737PHE T3740 | None | 1.05A | 4xeyA-5ojsT:undetectable | 4xeyA-5ojsT:7.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tz8 | GLYCOSYL TRANSFERASE (Staphylococcusaureus) |
PF00535(Glycos_transf_2) | 3 | MET A 225ASP A 178PHE A 181 | None | 0.96A | 4xeyA-5tz8A:undetectable | 4xeyA-5tz8A:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tzk | GLYCOSYL TRANSFERASE (Staphylococcusaureus) |
PF00535(Glycos_transf_2) | 3 | MET C 225ASP C 178PHE C 181 | NoneSO4 C 406 ( 4.6A)None | 0.99A | 4xeyA-5tzkC:undetectable | 4xeyA-5tzkC:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u3c | CTP SYNTHASE (Escherichiacoli) |
PF00117(GATase)PF06418(CTP_synth_N) | 3 | MET A 52ASP A 70PHE A 61 | None | 1.02A | 4xeyA-5u3cA:undetectable | 4xeyA-5u3cA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v54 | 5-HYDROXYTRYPTAMINERECEPTOR 1B,OB-1FUSED 5-HT1BRECEPTOR,5-HYDROXYTRYPTAMINE RECEPTOR 1B (Homo sapiens;Spodopterafrugiperda) |
no annotation | 3 | MET A 337ASP A 352PHE A 353 | None | 1.06A | 4xeyA-5v54A:undetectable | 4xeyA-5v54A:12.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vpu | 2,3-BISPHOSPHOGLYCERATE-INDEPENDENTPHOSPHOGLYCERATEMUTASE (Acinetobacterbaumannii) |
PF01676(Metalloenzyme)PF06415(iPGM_N) | 3 | MET A 72ASP A 83PHE A 84 | NoneNoneEDO A 607 ( 4.7A) | 0.80A | 4xeyA-5vpuA:undetectable | 4xeyA-5vpuA:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5whs | CATALASE-PEROXIDASE (Neurosporacrassa) |
no annotation | 3 | MET A 394ASP A 349PHE A 348 | None | 0.89A | 4xeyA-5whsA:undetectable | 4xeyA-5whsA:12.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xgu | RIBONUCLEASE R (Escherichiacoli) |
no annotation | 3 | MET B 246ASP B 194PHE B 193 | None | 1.06A | 4xeyA-5xguB:undetectable | 4xeyA-5xguB:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y8p | PROBABLE3-HYDROXYISOBUTYRATEDEHYDROGENASE (Mycobacteriumtuberculosis) |
no annotation | 3 | MET A 16ASP A 90PHE A 88 | None | 1.06A | 4xeyA-5y8pA:undetectable | 4xeyA-5y8pA:11.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cnh | SERINE/THREONINE-PROTEIN KINASE PRP4HOMOLOG (Homo sapiens) |
no annotation | 3 | MET A 985ASP A 978PHE A1002 | None | 1.01A | 4xeyA-6cnhA:21.0 | 4xeyA-6cnhA:13.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6evj | RNA-DIRECTED RNAPOLYMERASE CATALYTICSUBUNIT (Influenza Avirus) |
no annotation | 3 | MET B 711ASP B 165PHE B 166 | None | 0.96A | 4xeyA-6evjB:undetectable | 4xeyA-6evjB:11.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6grw | - (-) |
no annotation | 3 | MET A 89ASP A 253PHE A 84 | None | 0.99A | 4xeyA-6grwA:undetectable | 4xeyA-6grwA:undetectable |