SIMILAR PATTERNS OF AMINO ACIDS FOR 4XE5_A_OBNA1104_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR

(Escherichia
coli) 		PF12849
(PBP_like_2) 		4 PRO A  73
ILE A  76
VAL A  15
PHE A  11
 None
 0.99A 4xe5A-1a40A:
undetectable		 4xe5A-1a40A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE

(Human
alphaherpesvirus
2) 		PF00716
(Peptidase_S21) 		4 ILE A 121
VAL A  94
THR A 212
ARG A 226
 None
 1.17A 4xe5A-1at3A:
undetectable		 4xe5A-1at3A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb8 PROTEIN
(CHONDROITINASE AC)

(Pedobacter
heparinus) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 PRO A 410
ILE A 400
VAL A 290
ARG A 393
 None
 0.88A 4xe5A-1cb8A:
0.0		 4xe5A-1cb8A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpm GMP SYNTHETASE

(Escherichia
coli) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 ILE A  54
VAL A  23
PHE A 197
ARG A 174
 None
 0.88A 4xe5A-1gpmA:
2.6		 4xe5A-1gpmA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		4 ILE A 636
VAL A 625
PHE A 564
THR A 554
 None
 0.98A 4xe5A-1h7wA:
undetectable		 4xe5A-1h7wA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ILE A1063
VAL A1071
THR A1077
ARG A 793
 None
None
MTE  A3003 (-4.5A)
None
 0.96A 4xe5A-1n5xA:
0.0		 4xe5A-1n5xA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pmi PHOSPHOMANNOSE
ISOMERASE

(Candida
albicans) 		PF01238
(PMI_typeI) 		4 PRO A  96
PHE A 412
THR A  53
ARG A 436
 None
 1.11A 4xe5A-1pmiA:
undetectable		 4xe5A-1pmiA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pu7 3-METHYLADENINE DNA
GLYCOSYLASE

(Helicobacter
pylori) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		4 PRO A  86
VAL A  38
PHE A  45
THR A  43
 None
None
39A  A 219 (-3.5A)
None
 1.18A 4xe5A-1pu7A:
undetectable		 4xe5A-1pu7A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv5 HYPOTHETICAL PROTEIN
YWQG

(Bacillus
subtilis) 		PF09234
(DUF1963) 		4 PRO A 155
ILE A 182
THR A 164
ARG A  12
 None
 1.16A 4xe5A-1pv5A:
undetectable		 4xe5A-1pv5A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpt PROSTATIC ACID
PHOSPHATASE

(Rattus
norvegicus) 		PF00328
(His_Phos_2) 		5 ILE A 235
VAL A 295
PHE A   5
THR A 243
ARG A 249
 None
 1.48A 4xe5A-1rptA:
undetectable		 4xe5A-1rptA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ILE A  68
VAL A  33
THR A  16
ARG A 100
 None
None
UMA  A 963 (-3.6A)
None
 1.17A 4xe5A-1uagA:
undetectable		 4xe5A-1uagA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2i RV0130

(Mycobacterium
tuberculosis) 		PF01575
(MaoC_dehydratas) 		4 PRO A  99
ILE A  44
VAL A  31
THR A  66
 None
 1.10A 4xe5A-2c2iA:
undetectable		 4xe5A-2c2iA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Pyrococcus
furiosus) 		PF01380
(SIS) 		4 PRO A 293
PHE A 144
THR A 140
ARG A 151
 None
 1.13A 4xe5A-2cb0A:
4.1		 4xe5A-2cb0A:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chq REPLICATION FACTOR C
SMALL SUBUNIT

(Archaeoglobus
fulgidus) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 PRO A  13
ILE A  26
VAL A 161
PHE A 158
 ANP  A 700 (-4.0A)
None
None
None
 1.14A 4xe5A-2chqA:
2.4		 4xe5A-2chqA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5a LIPOYLTRANSFERASE 1

(Bos taurus) 		no annotation 4 PRO A  54
ILE A 246
THR A  79
ARG A  74
 None
 1.13A 4xe5A-2e5aA:
undetectable		 4xe5A-2e5aA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5f HYPOTHETICAL PROTEIN
PH0510

(Pyrococcus
horikoshii) 		PF01380
(SIS) 		4 PRO A 293
PHE A 144
THR A 140
ARG A 151
 None
 1.09A 4xe5A-2e5fA:
4.3		 4xe5A-2e5fA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9n EUKARYOTIC
INITIATION FACTOR
4A-I

(Homo sapiens) 		PF00270
(DEAD) 		4 PRO A  55
ILE A  30
VAL A 236
THR A  85
 MLY  A  54 ( 2.6A)
None
MLY  A 237 ( 3.0A)
MLY  A  82 ( 3.9A)
 1.09A 4xe5A-2g9nA:
undetectable		 4xe5A-2g9nA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 PRO A 512
ILE A 568
VAL A 532
PHE A 527
 None
None
SF4  A 610 ( 4.3A)
None
 1.19A 4xe5A-2gmhA:
2.9		 4xe5A-2gmhA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h18 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
8A

(Homo sapiens) 		PF00025
(Arf) 		4 ILE A  67
VAL A  39
PHE A  16
THR A 173
 None
 1.08A 4xe5A-2h18A:
2.8		 4xe5A-2h18A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjr MALATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 PRO A 285
ILE A 298
VAL A 277
THR A 269
 None
 1.14A 4xe5A-2hjrA:
3.7		 4xe5A-2hjrA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5p GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
1

(Kluyveromyces
marxianus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ILE O 161
VAL O 262
PHE O 292
THR O 290
 None
 1.05A 4xe5A-2i5pO:
4.7		 4xe5A-2i5pO:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 ILE A 107
VAL A 553
THR A  77
ARG A  71
 None
 1.17A 4xe5A-2inyA:
undetectable		 4xe5A-2inyA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 PRO X 348
ILE X 383
VAL X 395
THR X 130
 None
 1.19A 4xe5A-2iv2X:
4.7		 4xe5A-2iv2X:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjp CYTOCHROME P450
113A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		4 ILE A 111
VAL A 148
THR A 245
ARG A 364
 None
None
HEM  A 412 (-3.4A)
None
 1.18A 4xe5A-2jjpA:
undetectable		 4xe5A-2jjpA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jvn POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		PF08063
(PADR1) 		4 ILE A 248
VAL A 255
THR A 335
ARG A 282
 None
 0.81A 4xe5A-2jvnA:
undetectable		 4xe5A-2jvnA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0s FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		4 ILE A 212
VAL A  55
THR A  62
ARG A 224
 None
 1.17A 4xe5A-2n0sA:
2.3		 4xe5A-2n0sA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nmp CYSTATHIONINE
GAMMA-LYASE

(Homo sapiens) 		PF01053
(Cys_Met_Meta_PP) 		4 PRO A 198
ILE A 167
VAL A 176
ARG A 305
 None
 1.12A 4xe5A-2nmpA:
1.8		 4xe5A-2nmpA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4a CLAVAMINATE
SYNTHASE-LIKE
PROTEIN AT3G21360

(Arabidopsis
thaliana) 		PF02668
(TauD) 		4 ILE A  47
VAL A  64
PHE A 134
ARG A 104
 None
 1.19A 4xe5A-2q4aA:
undetectable		 4xe5A-2q4aA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgs PROTEIN SE1688

(Staphylococcus
epidermidis) 		no annotation 4 ILE A   7
VAL A  93
PHE A  79
THR A  61
 None
 1.19A 4xe5A-2qgsA:
2.0		 4xe5A-2qgsA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME

(Aeropyrum
pernix) 		PF00326
(Peptidase_S9) 		4 PRO A 370
ILE A 412
VAL A 175
THR A 401
 None
 0.94A 4xe5A-2qzpA:
2.0		 4xe5A-2qzpA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 ILE G 101
VAL G 251
PHE G 137
ARG G 135
 None
 1.16A 4xe5A-2uv8G:
undetectable		 4xe5A-2uv8G:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		4 ILE A 295
VAL A 714
THR A 616
ARG A 309
 None
 1.06A 4xe5A-2xsgA:
undetectable		 4xe5A-2xsgA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN

(Yersinia pestis) 		no annotation 4 PRO X  73
ILE X  76
VAL X  15
PHE X  11
 None
 0.99A 4xe5A-2z22X:
undetectable		 4xe5A-2z22X:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq9 PREDICTED ROSSMANN
FOLD
NUCLEOTIDE-BINDING
DOMAIN-CONTAINING
PROTEIN

(Idiomarina
baltica) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		4 PRO A 252
ILE A 315
VAL A 321
THR A 163
 None
 1.10A 4xe5A-3bq9A:
undetectable		 4xe5A-3bq9A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6v PROBABLE
TAUTOMERASE/DEHALOGE
NASE AU4130

(Aspergillus
fumigatus) 		PF14832
(Tautomerase_3) 		4 ILE A  66
VAL A  39
PHE A  -2
ARG A  79
 None
 1.18A 4xe5A-3c6vA:
undetectable		 4xe5A-3c6vA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e96 DIHYDRODIPICOLINATE
SYNTHASE

(Bacillus
clausii) 		PF00701
(DHDPS) 		4 ILE A 170
VAL A 166
PHE A 203
THR A 212
 None
 1.14A 4xe5A-3e96A:
undetectable		 4xe5A-3e96A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez9 PARA

(Salmonella
enterica) 		PF13614
(AAA_31) 		4 ILE A 147
VAL A 136
THR A 386
ARG A 397
 None
 1.16A 4xe5A-3ez9A:
undetectable		 4xe5A-3ez9A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbk REGULATOR OF
G-PROTEIN SIGNALING
3

(Homo sapiens) 		PF00168
(C2) 		4 PRO A  95
ILE A 131
VAL A 116
THR A  86
 None
 0.89A 4xe5A-3fbkA:
undetectable		 4xe5A-3fbkA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdy UDP-GALACTOPYRANOSE
MUTASE

(Deinococcus
radiodurans) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 PRO A 298
ILE A 122
VAL A 163
THR A 180
 None
GDU  A 500 ( 4.3A)
None
GDU  A 500 (-3.2A)
 1.14A 4xe5A-3hdyA:
undetectable		 4xe5A-3hdyA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3o SHORT CHAIN
DEHYDROGENASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		4 ILE A 226
VAL A 247
PHE A 243
THR A   9
 NAE  A 311 (-4.4A)
None
NAE  A 311 (-4.8A)
None
 1.19A 4xe5A-3i3oA:
undetectable		 4xe5A-3i3oA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 ILE A 196
VAL A 203
PHE A 263
THR A 101
 None
 0.75A 4xe5A-3jxfA:
undetectable		 4xe5A-3jxfA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l22 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 PRO A 442
VAL A 191
THR A 448
ARG A 418
 ACT  A  12 (-3.9A)
None
None
None
 1.14A 4xe5A-3l22A:
undetectable		 4xe5A-3l22A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mxl NITROSOSYNTHASE

(Micromonospora
sp. ATCC 39149) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ILE A 255
VAL A  93
THR A 213
ARG A 364
 None
 1.13A 4xe5A-3mxlA:
undetectable		 4xe5A-3mxlA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Streptomyces
avermitilis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 PRO A  84
ILE A 156
VAL A 185
ARG A 278
 None
 1.10A 4xe5A-3n05A:
undetectable		 4xe5A-3n05A:
21.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 PRO A 118
ILE A 315
THR A 797
ARG A 880
 OBN  A   1 (-3.6A)
None
OBN  A   1 (-2.8A)
OBN  A   1 (-3.7A)
 1.05A 4xe5A-3n23A:
47.7		 4xe5A-3n23A:
95.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 PRO A 118
VAL A 322
PHE A 783
ARG A 880
 OBN  A   1 (-3.6A)
OBN  A   1 (-3.2A)
OBN  A   1 (-3.5A)
OBN  A   1 (-3.7A)
 1.18A 4xe5A-3n23A:
47.7		 4xe5A-3n23A:
95.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaa ATP SYNTHASE SUBUNIT
BETA

(Escherichia
coli) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 PRO D  23
VAL D   6
THR D  53
ARG D  37
 None
 1.06A 4xe5A-3oaaD:
undetectable		 4xe5A-3oaaD:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p94 GDSL-LIKE LIPASE

(Parabacteroides
distasonis) 		PF13472
(Lipase_GDSL_2) 		4 ILE A 222
VAL A  73
PHE A  66
THR A  56
 None
 1.03A 4xe5A-3p94A:
undetectable		 4xe5A-3p94A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFE

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		4 ILE A 417
VAL A 327
PHE A 414
THR A 441
 None
 0.92A 4xe5A-3pdiA:
undetectable		 4xe5A-3pdiA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvu SULFOTRANSFERASE 1A1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 PRO A  74
ILE A 243
PHE A  84
THR A  95
 None
 1.12A 4xe5A-3qvuA:
undetectable		 4xe5A-3qvuA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2g INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE

(Legionella
pneumophila) 		PF00478
(IMPDH) 		4 ILE A 291
VAL A  45
PHE A  61
THR A  54
 None
 1.17A 4xe5A-3r2gA:
undetectable		 4xe5A-3r2gA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6b METHIONINE
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24) 		4 PRO A 356
ILE A 214
VAL A 225
THR A 361
 None
 1.08A 4xe5A-3s6bA:
undetectable		 4xe5A-3s6bA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8d COENZYME A
TRANSFERASE

(Yersinia pestis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 ILE A  21
VAL A  57
THR A  69
ARG A  49
 None
 1.16A 4xe5A-3s8dA:
undetectable		 4xe5A-3s8dA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ILE C1063
VAL C1071
THR C1077
ARG C 793
 None
 0.92A 4xe5A-3sr6C:
undetectable		 4xe5A-3sr6C:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v6a APOPTOSIS INHIBITOR
5

(Homo sapiens) 		PF05918
(API5) 		4 ILE A 197
VAL A 171
PHE A 137
ARG A 148
 None
 1.09A 4xe5A-3v6aA:
undetectable		 4xe5A-3v6aA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v6a APOPTOSIS INHIBITOR
5

(Homo sapiens) 		PF05918
(API5) 		4 ILE A 197
VAL A 171
PHE A 137
THR A 132
 None
 1.13A 4xe5A-3v6aA:
undetectable		 4xe5A-3v6aA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3won DIPEPTIDYL
AMINOPEPTIDASE BII

(Pseudoxanthomonas
mexicana) 		PF10459
(Peptidase_S46) 		4 PRO A 273
ILE A 581
VAL A 661
THR A  71
 None
 1.18A 4xe5A-3wonA:
undetectable		 4xe5A-3wonA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq4 BETA-PRIMEVEROSIDASE

(Camellia
sinensis) 		PF00232
(Glyco_hydro_1) 		4 ILE A 302
VAL A 333
PHE A 337
THR A 200
 None
 1.18A 4xe5A-3wq4A:
undetectable		 4xe5A-3wq4A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3t DNA MISMATCH REPAIR
PROTEIN HSM3

(Saccharomyces
cerevisiae) 		no annotation 4 ILE A  29
VAL A  79
PHE A  61
THR A  57
 None
 1.13A 4xe5A-4a3tA:
undetectable		 4xe5A-4a3tA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4alq CHITIN BINDING
PROTEIN

(Enterococcus
faecalis) 		PF03067
(LPMO_10) 		4 ILE A 160
VAL A  32
THR A  97
ARG A 166
 None
 1.19A 4xe5A-4alqA:
undetectable		 4xe5A-4alqA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc4 NITRITE TRANSPORTER
NIRC

(Salmonella
enterica) 		PF01226
(Form_Nir_trans) 		4 ILE A  73
PHE A  86
THR A   5
ARG A  15
 None
 1.02A 4xe5A-4fc4A:
undetectable		 4xe5A-4fc4A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcy TRANSPOSASE

(Escherichia
virus Mu) 		PF02316
(HTH_Tnp_Mu_1)
PF02914
(DDE_2)
PF09039
(HTH_Tnp_Mu_2)
PF09299
(Mu-transpos_C) 		4 PRO A 328
ILE A 266
PHE A 468
ARG A 324
 None
 1.13A 4xe5A-4fcyA:
undetectable		 4xe5A-4fcyA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF13306
(LRR_5) 		4 PRO A  99
ILE A  29
VAL A  63
PHE A  87
 None
 1.05A 4xe5A-4fs7A:
undetectable		 4xe5A-4fs7A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2

(Sulfolobus
solfataricus) 		PF10040
(CRISPR_Cas6) 		4 PRO A  20
ILE A  75
VAL A  11
THR A 105
 None
 1.18A 4xe5A-4ilrA:
undetectable		 4xe5A-4ilrA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldc DOUBLE C2-LIKE
DOMAIN-CONTAINING
PROTEIN BETA

(Rattus
norvegicus) 		PF00168
(C2) 		4 PRO A 331
ILE A 367
VAL A 353
THR A 322
 None
 0.86A 4xe5A-4ldcA:
undetectable		 4xe5A-4ldcA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ngu TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Desulfovibrio
alaskensis) 		PF03480
(DctP) 		4 PRO A 220
ILE A 226
VAL A 205
THR A 163
 None
 0.97A 4xe5A-4nguA:
undetectable		 4xe5A-4nguA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov4 2-ISOPROPYLMALATE
SYNTHASE

(Leptospira
biflexa) 		PF00682
(HMGL-like) 		4 ILE A   8
VAL A 220
THR A 208
ARG A  97
 None
 1.18A 4xe5A-4ov4A:
undetectable		 4xe5A-4ov4A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p47 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ochrobactrum
anthropi) 		PF03480
(DctP) 		4 ILE A 312
PHE A 328
THR A 323
ARG A 335
 None
 1.18A 4xe5A-4p47A:
undetectable		 4xe5A-4p47A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4reg UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF01905
(DevR) 		5 PRO A  48
ILE A 148
VAL A  44
PHE A 282
ARG A   8
 None
 1.49A 4xe5A-4regA:
undetectable		 4xe5A-4regA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE

(Beutenbergia
cavernae) 		PF03372
(Exo_endo_phos) 		4 ILE A 235
VAL A 217
PHE A 296
ARG A 265
 None
 1.12A 4xe5A-4ruwA:
undetectable		 4xe5A-4ruwA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ts6 RAB3 INTERACTING
MOLECULE VARIANT 2

(Drosophila
melanogaster) 		PF00168
(C2) 		4 PRO A 903
ILE A 940
VAL A 926
THR A 894
 None
 0.89A 4xe5A-4ts6A:
undetectable		 4xe5A-4ts6A:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuu CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00571
(CBS) 		4 PRO A 422
ILE A 455
VAL A 459
PHE A 487
 SAM  A1546 (-4.7A)
None
None
None
 1.04A 4xe5A-4uuuA:
undetectable		 4xe5A-4uuuA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v11 SYNAPTOTAGMIN-1

(Homo sapiens) 		PF00168
(C2) 		4 PRO A 338
ILE A 374
VAL A 360
THR A 329
 None
 0.83A 4xe5A-4v11A:
undetectable		 4xe5A-4v11A:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr3 ALANINE RACEMASE,
BIOSYNTHETIC

(Escherichia
coli) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 PRO A 219
ILE A 197
VAL A  32
ARG A  19
 None
None
PLP  A1001 ( 4.6A)
None
 1.17A 4xe5A-4wr3A:
undetectable		 4xe5A-4wr3A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus AP22) 		no annotation 4 PRO A 483
ILE A 510
VAL A 576
ARG A 472
 None
 1.07A 4xe5A-4y9vA:
undetectable		 4xe5A-4y9vA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ILE A 127
VAL A 572
PHE A 698
THR A 675
 None
 0.97A 4xe5A-5a7mA:
4.8		 4xe5A-5a7mA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwe BENZYLSUCCINATE
SYNTHASE BETA CHAIN

(Thauera
aromatica) 		no annotation 4 PRO B  36
VAL B  54
THR B  33
ARG B  60
 None
 1.19A 4xe5A-5bweB:
undetectable		 4xe5A-5bweB:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		4 ILE A 217
VAL A 224
PHE A 284
THR A 123
 None
 0.90A 4xe5A-5e5uA:
undetectable		 4xe5A-5e5uA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		4 PRO A 251
ILE A 144
VAL A 260
THR A 274
 None
 0.84A 4xe5A-5ej1A:
undetectable		 4xe5A-5ej1A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffj ENDONUCLEASE AND
METHYLASE LLAGI

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII) 		4 PRO A 903
ILE A1081
VAL A1084
ARG A1069
 None
 1.12A 4xe5A-5ffjA:
1.6		 4xe5A-5ffjA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fya PATATIN-LIKE
PROTEIN, PLPD

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		4 VAL A 206
PHE A 176
THR A  59
ARG A 177
 None
 1.18A 4xe5A-5fyaA:
undetectable		 4xe5A-5fyaA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzp TRIOSEPHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF00121
(TIM) 		4 ILE A 206
VAL A 151
PHE A 127
THR A 144
 None
 0.88A 4xe5A-5gzpA:
undetectable		 4xe5A-5gzpA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb5 NUCLEOPORIN NUP145

(Chaetomium
thermophilum) 		PF04096
(Nucleoporin2) 		4 ILE A  56
VAL A  36
PHE A  26
ARG A  20
 None
 1.01A 4xe5A-5hb5A:
undetectable		 4xe5A-5hb5A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i84 PHOSPHATE-BINDING
PROTEIN PSTS

(Xanthomonas
citri) 		PF12849
(PBP_like_2) 		4 PRO A  97
ILE A 100
VAL A  39
PHE A  35
 None
 1.12A 4xe5A-5i84A:
undetectable		 4xe5A-5i84A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixd TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 4 ILE A 384
VAL A 381
PHE A 405
THR A 288
 None
 1.18A 4xe5A-5ixdA:
undetectable		 4xe5A-5ixdA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale) 		PF07992
(Pyr_redox_2) 		4 PRO A 211
ILE A 307
VAL A 215
THR A 191
 None
 1.15A 4xe5A-5m10A:
undetectable		 4xe5A-5m10A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mbh BETA SUBUNIT OF
PHOTOACTIVATED
ADENYLYL CYCLASE

(Beggiatoa sp.
PS) 		PF00211
(Guanylate_cyc)
PF04940
(BLUF) 		4 ILE A 199
VAL A 195
PHE A 155
ARG A 278
 None
 1.14A 4xe5A-5mbhA:
undetectable		 4xe5A-5mbhA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr7 GRAINYHEAD-LIKE
PROTEIN 2 HOMOLOG

(Homo sapiens) 		no annotation 4 ILE A 393
PHE A 357
THR A 343
ARG A 297
 None
 1.07A 4xe5A-5mr7A:
undetectable		 4xe5A-5mr7A:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME

(Lysobacter sp.
XL1) 		no annotation 4 PRO A  26
ILE A   7
VAL A  48
ARG A 107
 None
 0.94A 4xe5A-5mrtA:
undetectable		 4xe5A-5mrtA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		4 ILE A 310
VAL A 358
PHE A 363
THR A 365
 None
None
None
FMT  A 510 ( 4.8A)
 1.07A 4xe5A-5v0tA:
undetectable		 4xe5A-5v0tA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9x ATP-DEPENDENT DNA
HELICASE

(Mycolicibacterium
smegmatis) 		no annotation 4 ILE A 416
VAL A 241
PHE A 636
ARG A 630
 None
 1.19A 4xe5A-5v9xA:
undetectable		 4xe5A-5v9xA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9x ATP-DEPENDENT DNA
HELICASE

(Mycolicibacterium
smegmatis) 		no annotation 4 PRO A 139
ILE A 143
VAL A 167
PHE A  59
 None
 1.19A 4xe5A-5v9xA:
undetectable		 4xe5A-5v9xA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 4 ILE A 157
VAL A 477
PHE A 274
THR A 422
 None
 1.13A 4xe5A-5xqoA:
undetectable		 4xe5A-5xqoA:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysb LIN1841 PROTEIN

(Listeria
innocua) 		no annotation 4 PRO A 194
ILE A 236
VAL A 229
THR A 199
 None
 1.11A 4xe5A-5ysbA:
undetectable		 4xe5A-5ysbA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b8a DNA-BINDING
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		no annotation 4 ILE A 147
VAL A 122
PHE A 284
ARG A 289
 None
 1.19A 4xe5A-6b8aA:
undetectable		 4xe5A-6b8aA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhq IGH PROTEIN

(Mus musculus) 		no annotation 4 PRO A 374
ILE A 247
VAL A 379
THR A 396
 None
 1.14A 4xe5A-6bhqA:
undetectable		 4xe5A-6bhqA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chd LYSINE--TRNA LIGASE

(Homo sapiens) 		no annotation 4 ILE A 353
PHE A 486
THR A 500
ARG A 393
 None
 1.17A 4xe5A-6chdA:
undetectable		 4xe5A-6chdA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza

() 		no annotation 4 PRO B 184
ILE A 229
VAL A 745
PHE B 228
 SF4  B 301 ( 4.8A)
None
None
None
 1.13A 4xe5A-6czaB:
undetectable		 4xe5A-6czaB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44

(Homo sapiens) 		no annotation 4 PRO K 375
ILE K 402
VAL K 417
ARG K 384
 A  O  51 ( 4.5A)
None
None
A  O  48 ( 3.6A)
 1.13A 4xe5A-6d6qK:
undetectable		 4xe5A-6d6qK:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza B
virus) 		no annotation 4 ILE B 248
VAL B 254
PHE B 413
THR B 322
 None
 1.09A 4xe5A-6f5oB:
undetectable		 4xe5A-6f5oB:
6.56