SIMILAR PATTERNS OF AMINO ACIDS FOR 4XE5_A_OBNA1104

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b07 PROTEIN
(PROTO-ONCOGENE CRK
(CRK))

(Mus musculus) 		PF00018
(SH3_1) 		5 GLU A 176
ASP A 174
GLY A 156
ALA A 139
ILE A 182
 None
 1.29A 4xe5A-1b07A:
undetectable		 4xe5A-1b07A:
5.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		5 ASP A 379
LEU A 383
GLU A 353
GLU A 388
ASP A 513
 None
 1.00A 4xe5A-1biyA:
0.4		 4xe5A-1biyA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddb PROTEIN (BID)

(Mus musculus) 		PF06393
(BID) 		6 GLU A  41
ASP A  18
GLU A  36
GLY A  23
ALA A  87
ILE A 178
 None
 1.49A 4xe5A-1ddbA:
undetectable		 4xe5A-1ddbA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1c METHYLMALONYL-COA
MUTASE ALPHA CHAIN

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		5 ASP A 148
GLY A 539
ALA A 176
ILE A 174
ASP A 128
 None
 1.18A 4xe5A-1e1cA:
2.5		 4xe5A-1e1cA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek2 EPOXIDE HYDROLASE

(Mus musculus) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		5 GLU A 267
LEU A 395
GLU A 445
GLU A 394
ILE A 427
 None
 1.27A 4xe5A-1ek2A:
undetectable		 4xe5A-1ek2A:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eq9 CHYMOTRYPSIN

(Solenopsis
invicta) 		PF00089
(Trypsin) 		5 GLU A 159
LEU A 184
GLU A 157
GLY A 189
ALA A 221
 None
 1.19A 4xe5A-1eq9A:
undetectable		 4xe5A-1eq9A:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxk CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF06470
(SMC_hinge) 		5 LEU A 613
GLU A 645
GLY A 539
ALA A 542
ILE A 524
 None
 0.96A 4xe5A-1gxkA:
undetectable		 4xe5A-1gxkA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8q HYALURONATE LYASE

(Streptococcus
agalactiae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 GLY A 764
ALA A 748
PHE A 674
ILE A 767
ASP A 793
 None
 1.24A 4xe5A-1i8qA:
0.7		 4xe5A-1i8qA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 GLU A 226
GLY A 382
ALA A 463
GLU A 459
ILE A 471
 None
 1.25A 4xe5A-1lpfA:
3.4		 4xe5A-1lpfA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pw5 NAGD PROTEIN,
PUTATIVE

(Thermotoga
maritima) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 ASP A 213
LEU A 210
GLY A 230
GLU A 235
PHE A 246
 SO4  A 302 ( 4.7A)
None
None
NDG  A 254 (-3.1A)
None
 1.28A 4xe5A-1pw5A:
6.8		 4xe5A-1pw5A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3n BETA-ALANINE
SYNTHASE

(Lachancea
kluyveri) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLU A 160
GLY A 129
ALA A 132
PHE A 412
ILE A 432
 ZN  A 501 (-2.0A)
None
None
None
None
 1.29A 4xe5A-1r3nA:
undetectable		 4xe5A-1r3nA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tf1 NEGATIVE REGULATOR
OF ALLANTOIN AND
GLYOXYLATE
UTILIZATION OPERONS

(Escherichia
coli) 		PF01614
(IclR) 		5 LEU A 111
GLU A 124
GLY A  70
ALA A  74
PHE A 162
 None
 1.30A 4xe5A-1tf1A:
undetectable		 4xe5A-1tf1A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woq INORGANIC
POLYPHOSPHATE/ATP-GL
UCOMANNOKINASE

(Arthrobacter
sp. KM) 		PF00480
(ROK) 		5 GLU A  70
LEU A  31
GLU A  64
GLY A  16
ALA A 255
 None
 1.12A 4xe5A-1woqA:
undetectable		 4xe5A-1woqA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzc MANNOSYL-3-PHOSPHOGL
YCERATE PHOSPHATASE

(Pyrococcus
horikoshii) 		PF08282
(Hydrolase_3) 		5 GLU A 141
GLY A  65
ALA A 183
PHE A  60
ILE A  90
 None
 1.19A 4xe5A-1wzcA:
5.4		 4xe5A-1wzcA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9y CYSTEINE PROTEINASE

(Staphylococcus
aureus) 		PF05543
(Peptidase_C47)
PF14731
(Staphopain_pro) 		5 GLU A 162
ASP A 161
LEU A 159
GLY A  95
GLU A 168
 None
 1.15A 4xe5A-1x9yA:
undetectable		 4xe5A-1x9yA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk7 MERCURIC REDUCTASE

(Pseudomonas
aeruginosa) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 462
GLU A 413
GLY A 447
ALA A 451
ASP A 388
 None
 1.27A 4xe5A-1zk7A:
undetectable		 4xe5A-1zk7A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2o HYPOTHETICAL PROTEIN
BT3146

(Bacteroides
thetaiotaomicron) 		no annotation 5 GLY A  61
ALA A  63
PHE A 233
ILE A 189
ASP A  79
 None
None
EDO  A 249 ( 4.3A)
None
EDO  A 248 ( 4.1A)
 1.28A 4xe5A-2a2oA:
undetectable		 4xe5A-2a2oA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 LEU A 293
GLU A 341
ALA A 352
PHE A 367
ILE A 356
 None
 1.28A 4xe5A-2dieA:
undetectable		 4xe5A-2dieA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef4 ARGINASE

(Thermus
thermophilus) 		PF00491
(Arginase) 		5 LEU A 151
GLY A 102
ALA A  74
ILE A  70
ASP A 119
 None
 1.21A 4xe5A-2ef4A:
undetectable		 4xe5A-2ef4A:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f59 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
1

(Brucella
abortus) 		PF00885
(DMRL_synthase) 		5 GLU A 123
LEU A  30
ALA A  20
PHE A  91
ILE A 117
 None
None
INI  A 201 ( 3.7A)
INI  A 201 (-4.0A)
None
 1.29A 4xe5A-2f59A:
undetectable		 4xe5A-2f59A:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fck RIBOSOMAL-PROTEIN-SE
RINE
ACETYLTRANSFERASE,
PUTATIVE

(Vibrio cholerae) 		PF13302
(Acetyltransf_3) 		5 GLN A  13
LEU A  16
GLU A  74
GLY A  71
ILE A  55
 None
 1.28A 4xe5A-2fckA:
undetectable		 4xe5A-2fckA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fvg ENDOGLUCANASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		5 GLU A 179
ASP A 176
GLU A  28
ALA A  59
PHE A  22
 None
 1.18A 4xe5A-2fvgA:
undetectable		 4xe5A-2fvgA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hvq HYPOTHETICAL 37.6
KDA PROTEIN IN
GP24-HOC INTERGENIC
REGION

(Escherichia
virus T4) 		PF09414
(RNA_ligase) 		5 GLU A 246
LEU A 317
GLU A 249
GLY A 256
ALA A 259
 None
 1.23A 4xe5A-2hvqA:
2.2		 4xe5A-2hvqA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5g AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		5 GLU A 167
GLU A 168
GLU A 198
ILE A 145
ASP A 135
 None
 1.27A 4xe5A-2i5gA:
undetectable		 4xe5A-2i5gA:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7x PROTEIN CFT2

(Saccharomyces
cerevisiae) 		PF16661
(Lactamase_B_6) 		5 GLU A 344
ASP A 103
GLU A 372
GLY A  68
ILE A 111
 None
 1.29A 4xe5A-2i7xA:
2.6		 4xe5A-2i7xA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLN A 430
LEU A 422
GLU A 431
ALA A 373
PHE A 438
 None
 1.24A 4xe5A-2iwzA:
undetectable		 4xe5A-2iwzA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lv7 CALCIUM-BINDING
PROTEIN 7

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 GLU A  92
GLU A  93
LEU A  98
ALA A  41
ASP A  86
 None
CA  A 202 (-2.4A)
None
None
CA  A 202 (-3.2A)
 1.29A 4xe5A-2lv7A:
undetectable		 4xe5A-2lv7A:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owi REGULATOR OF
G-PROTEIN SIGNALING
18

(Homo sapiens) 		PF00615
(RGS) 		5 GLU A  13
LEU A 129
GLY A  24
ALA A  27
ILE A 125
 None
 1.26A 4xe5A-2owiA:
2.5		 4xe5A-2owiA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnz PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1

(Pyrococcus
abyssi) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 ASP A  12
GLY A 183
GLU A 211
ILE A 171
ASP A  19
 None
MPD  A 251 (-4.5A)
None
None
None
 1.21A 4xe5A-2pnzA:
undetectable		 4xe5A-2pnzA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps2 PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Aspergillus
oryzae) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLU A 222
ASP A 196
ALA A 183
PHE A 192
ILE A 142
 MG  A 401 (-3.2A)
MG  A 401 (-2.6A)
None
None
None
 1.17A 4xe5A-2ps2A:
undetectable		 4xe5A-2ps2A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6r CELL DIVISION
PROTEIN FTSZ

(Aquifex
aeolicus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLU 1  28
ASP 1 183
LEU 1 186
GLY 1  14
ALA 1  99
 None
GDP  1 339 (-3.2A)
None
None
None
 1.23A 4xe5A-2r6r1:
undetectable		 4xe5A-2r6r1:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4i GLUTAMATE RACEMASE

(Helicobacter
pylori) 		PF01177
(Asp_Glu_race) 		5 LEU A  19
GLU A 251
GLY A  12
ALA A  69
ILE A 214
 None
 1.29A 4xe5A-2w4iA:
undetectable		 4xe5A-2w4iA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7j 2-SUCCINYL-5-ENOLPYR
UVYL-6-HYDROXY-3-CYC
LOHEXENE
-1-CARBOXYLATE
SYNTHASE

(Bacillus
subtilis) 		PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
PF16582
(TPP_enzyme_M_2) 		5 GLU A 279
LEU A 275
ALA A 270
PHE A 363
ILE A 268
 None
 1.25A 4xe5A-2x7jA:
3.1		 4xe5A-2x7jA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9x SELENOCYSTEINE LYASE

(Rattus
norvegicus) 		PF00266
(Aminotran_5) 		5 GLU A 285
GLU A 277
GLY A 294
ALA A 297
ILE A 243
 None
 1.29A 4xe5A-3a9xA:
undetectable		 4xe5A-3a9xA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b40 PROBABLE DIPEPTIDASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		5 GLU A 405
ASP A 402
LEU A  81
GLU A  47
GLY A  87
 None
 1.27A 4xe5A-3b40A:
undetectable		 4xe5A-3b40A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		5 GLN A 814
ASP A 761
LEU A 767
GLU A 831
ALA A 826
 None
 1.27A 4xe5A-3bgaA:
undetectable		 4xe5A-3bgaA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq9 PREDICTED ROSSMANN
FOLD
NUCLEOTIDE-BINDING
DOMAIN-CONTAINING
PROTEIN

(Idiomarina
baltica) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		5 GLN A 432
GLU A 431
LEU A 295
GLY A 254
ALA A 258
 GOL  A 463 ( 3.8A)
None
None
SO4  A 460 (-3.5A)
None
 1.23A 4xe5A-3bq9A:
undetectable		 4xe5A-3bq9A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlj BETA-ALA-HIS
DIPEPTIDASE

(Homo sapiens) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLU A 451
GLY A 142
ALA A 146
ILE A 464
ASP A 448
 None
 1.17A 4xe5A-3dljA:
undetectable		 4xe5A-3dljA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dx5 UNCHARACTERIZED
PROTEIN ASBF

(Bacillus
anthracis) 		PF01261
(AP_endonuc_2) 		5 GLN A  22
GLU A  26
LEU A  57
PHE A  10
ILE A  64
 None
None
GOL  A 291 ( 4.3A)
None
None
 1.21A 4xe5A-3dx5A:
undetectable		 4xe5A-3dx5A:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ejw SMLSRB

(Sinorhizobium
meliloti) 		PF13407
(Peripla_BP_4) 		5 ASP A  90
GLU A 301
GLY A 247
ALA A  23
PHE A 315
 PAV  A 400 (-2.8A)
None
None
None
None
 1.21A 4xe5A-3ejwA:
3.2		 4xe5A-3ejwA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gb0 PEPTIDASE T

(Bacillus cereus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ASP A 241
GLU A 198
GLY A 276
ALA A 272
ILE A 186
 None
 1.23A 4xe5A-3gb0A:
undetectable		 4xe5A-3gb0A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307

([Ruminococcus]
gnavus) 		PF02645
(DegV) 		5 GLU A 258
GLU A 257
GLU A 262
GLY A 293
ALA A 289
 None
None
None
None
PG6  A 299 ( 4.6A)
 1.26A 4xe5A-3jr7A:
undetectable		 4xe5A-3jr7A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1j ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF05362
(Lon_C)
PF13654
(AAA_32) 		5 GLU A 585
ASP A 587
GLU A 604
GLY A 549
ALA A 523
 None
 1.11A 4xe5A-3k1jA:
3.3		 4xe5A-3k1jA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6r SERINE RACEMASE

(Homo sapiens) 		PF00291
(PALP) 		5 GLU A 283
GLU A  47
GLY A 289
ALA A 292
GLU A 266
 LLP  A  56 ( 3.6A)
None
None
None
None
 1.28A 4xe5A-3l6rA:
3.0		 4xe5A-3l6rA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE

(Sus scrofa) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 GLN A  95
GLU A  99
GLY A 265
ALA A 267
ILE A 339
 CO8  A 400 ( 4.7A)
None
None
None
None
 1.17A 4xe5A-3mdeA:
2.6		 4xe5A-3mdeA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn1 PROBABLE YRBI FAMILY
PHOSPHATASE

(Pseudomonas
savastanoi) 		PF08282
(Hydrolase_3) 		5 LEU A  10
GLY A 130
ALA A 144
ILE A 147
ASP A  49
 None
 1.29A 4xe5A-3mn1A:
17.6		 4xe5A-3mn1A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mog PROBABLE
3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Escherichia
coli) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 GLU A  39
LEU A  33
GLY A  14
ALA A  18
ILE A  48
 None
 1.25A 4xe5A-3mogA:
3.2		 4xe5A-3mogA:
19.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		9 ASP A 121
LEU A 125
GLU A 312
GLY A 319
ALA A 323
GLU A 327
PHE A 786
ILE A 800
ASP A 884
 OBN  A   1 (-3.4A)
None
None
OBN  A   1 ( 4.8A)
OBN  A   1 (-3.2A)
None
None
OBN  A   1 ( 4.7A)
OBN  A   1 ( 4.8A)
 0.82A 4xe5A-3n23A:
47.7		 4xe5A-3n23A:
95.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, ALPHA
SUBUNIT
PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Roseobacter
denitrificans;
Ruegeria
pomeroyi) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 GLN A 643
GLU B  76
GLU A 645
ALA A 530
ILE A 572
 None
 1.23A 4xe5A-3n6rA:
2.5		 4xe5A-3n6rA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1

(Mus musculus) 		PF00856
(SET)
PF01753
(zf-MYND) 		5 ASP A  45
LEU A  47
GLY A 194
ALA A 192
ASP A 150
 GOL  A 493 (-4.9A)
None
None
None
None
 1.18A 4xe5A-3n71A:
undetectable		 4xe5A-3n71A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pk0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 LEU A 228
GLU A 174
GLY A 238
ALA A 240
PHE A 167
 None
 1.24A 4xe5A-3pk0A:
5.1		 4xe5A-3pk0A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pk0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 LEU A 228
GLU A 174
GLY A 238
PHE A 167
ILE A 185
 None
 1.29A 4xe5A-3pk0A:
5.1		 4xe5A-3pk0A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnr FALCIPAIN 2

(Plasmodium
falciparum) 		PF00112
(Peptidase_C1) 		5 GLU A 241
LEU A 129
GLY A 144
ALA A 139
ILE A   8
 None
 1.18A 4xe5A-3pnrA:
undetectable		 4xe5A-3pnrA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 GLU A 227
GLU A 119
LEU A 424
GLU A 276
ASP A 151
 LNV  A 901 (-3.4A)
LNV  A 901 (-3.6A)
None
LNV  A 901 (-2.9A)
LNV  A 901 (-3.4A)
 1.03A 4xe5A-3ti8A:
undetectable		 4xe5A-3ti8A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txx PUTRESCINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 GLN A  50
GLU A 105
ASP A 127
GLY A 124
GLU A 134
 None
 1.16A 4xe5A-3txxA:
undetectable		 4xe5A-3txxA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl4 UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF02585
(PIG-L) 		5 GLU A 146
GLY A  47
ALA A  45
GLU A  92
PHE A 230
 None
 1.08A 4xe5A-3wl4A:
undetectable		 4xe5A-3wl4A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zh4 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Streptococcus
pneumoniae) 		PF00275
(EPSP_synthase) 		5 GLU A 192
GLY A 302
ALA A 298
ILE A 328
ASP A 233
 None
 1.23A 4xe5A-3zh4A:
undetectable		 4xe5A-3zh4A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zid TUBULIN/FTSZ, GTPASE

(Methanothrix
thermoacetophila) 		PF00091
(Tubulin) 		5 GLU A 292
GLU A 288
GLU A 294
GLY A 306
ILE A 309
 None
 1.27A 4xe5A-3zidA:
2.8		 4xe5A-3zidA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a05 CELLOBIOHYDROLASE
FAMILY 6

(Chaetomium
thermophilum) 		PF01341
(Glyco_hydro_6) 		5 GLU A 250
ASP A 294
LEU A 330
ALA A 310
ASP A 206
 None
None
None
None
CTT  A 503 (-3.1A)
 1.08A 4xe5A-4a05A:
undetectable		 4xe5A-4a05A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au0 EXOGLUCANASE 2

(Trichoderma
reesei) 		PF01341
(Glyco_hydro_6) 		5 GLU A 219
ASP A 263
LEU A 299
ALA A 279
ASP A 175
 None
None
None
None
BGC  A 602 (-3.1A)
 1.04A 4xe5A-4au0A:
undetectable		 4xe5A-4au0A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8n CYTOCHROME B5-HOST
ORIGIN

(Ostreococcus
tauri virus 2) 		PF00173
(Cyt-b5) 		5 GLU A  27
GLU A  28
GLY A  60
ALA A  22
GLU A  20
 None
 1.18A 4xe5A-4b8nA:
undetectable		 4xe5A-4b8nA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccd GALACTOCEREBROSIDASE

(Mus musculus) 		PF02057
(Glyco_hydro_59)
PF17387
(Glyco_hydro_59M) 		5 ASP A  89
GLY A  95
ALA A  50
GLU A 114
PHE A 498
 None
 1.20A 4xe5A-4ccdA:
undetectable		 4xe5A-4ccdA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fim LACTOTRANSFERRIN

(Bos taurus) 		PF00405
(Transferrin) 		5 ASP A 379
LEU A 383
GLU A 353
GLU A 388
ASP A 513
 None
 1.15A 4xe5A-4fimA:
undetectable		 4xe5A-4fimA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2l ALPHA-GLOBIN

(Peromyscus
maniculatus) 		PF00042
(Globin) 		5 GLU A  30
LEU A 105
GLY A  59
ALA A  63
ILE A  17
 None
 0.94A 4xe5A-4h2lA:
2.0		 4xe5A-4h2lA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhr ALPHA-DIOXYGENASE

(Arabidopsis
thaliana) 		PF03098
(An_peroxidase) 		5 GLU A 533
LEU A 137
GLU A 497
GLY A 539
ALA A 542
 None
 1.25A 4xe5A-4hhrA:
2.7		 4xe5A-4hhrA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htg PORPHOBILINOGEN
DEAMINASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		5 GLU A 234
LEU A 228
GLY A 214
ALA A 216
ILE A 105
 None
 1.25A 4xe5A-4htgA:
undetectable		 4xe5A-4htgA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcr ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT

(Listeria
monocytogenes) 		PF00574
(CLP_protease) 		5 GLU A 103
GLU A 101
LEU A  98
GLY A 152
ALA A 148
 None
 1.13A 4xe5A-4jcrA:
undetectable		 4xe5A-4jcrA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw1 EFFECTOR PROTEIN B

(Legionella
pneumophila) 		no annotation 5 GLN A  81
ASP A 256
LEU A 257
GLU A  83
GLY A  88
 None
 1.26A 4xe5A-4jw1A:
2.9		 4xe5A-4jw1A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6l CYTOLETHAL
DISTENDING TOXIN
SUBUNIT B HOMOLOG

(Salmonella
enterica) 		PF03372
(Exo_endo_phos) 		5 ASP F 195
GLY F 235
ALA F 220
ILE F 231
ASP F 168
 None
 1.18A 4xe5A-4k6lF:
undetectable		 4xe5A-4k6lF:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7u UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		5 GLU A 191
GLY A 302
ALA A 298
ILE A 328
ASP A 232
 None
None
None
UD1  A 503 (-4.7A)
None
 1.19A 4xe5A-4r7uA:
undetectable		 4xe5A-4r7uA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u39 CELL DIVISION
PROTEIN FTSZ

(Bacillus
subtilis) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 GLU A  32
ASP A 187
LEU A 190
GLY A  18
ALA A 103
 None
 1.22A 4xe5A-4u39A:
3.2		 4xe5A-4u39A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE

(Shigella sonnei) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 GLU A 284
GLU A 290
ASP A 585
GLY A 444
ILE A 593
 None
 1.27A 4xe5A-4umvA:
24.9		 4xe5A-4umvA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BOTULINUM NEUROTOXIN
TYPE E,
NONTOXIC-NONHEMAGGLU
TININ COMPONENT,
NTNH

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07953
(Toxin_R_bind_N)
PF08470
(NTNH_C) 		5 GLU B 802
ASP B 818
LEU B 805
GLU B 860
ILE B 816
 None
 1.10A 4xe5A-4zktB:
undetectable		 4xe5A-4zktB:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5af3 VAPBC49

(Mycobacterium
tuberculosis) 		PF04255
(DUF433) 		5 GLU A  20
LEU A  25
GLY A  72
ALA A  74
ILE A 173
 None
 1.22A 4xe5A-5af3A:
undetectable		 4xe5A-5af3A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cx7 ATP:COB(I)ALAMIN
ADENOSYLTRANSFERASE

(Salmonella
enterica) 		PF03928
(Haem_degrading) 		5 LEU A 110
GLU A 128
GLY A 107
ALA A  67
ILE A  39
 None
 1.16A 4xe5A-5cx7A:
undetectable		 4xe5A-5cx7A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d01 N-ACETYL-ALPHA-D-GLU
COSAMINYL L-MALATE
SYNTHASE

(Bacillus
subtilis) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 GLU A 339
ASP A 274
GLY A 296
ALA A 292
ILE A 203
 None
 1.24A 4xe5A-5d01A:
4.4		 4xe5A-5d01A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		5 GLU A1265
ASP A1128
GLY A1231
GLU A1199
ASP A1343
 None
 1.27A 4xe5A-5d0fA:
undetectable		 4xe5A-5d0fA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML

(Bacillus
velezensis) 		PF13847
(Methyltransf_31) 		5 GLU A 194
GLU A 195
LEU A 200
GLY A 215
ILE A 159
 None
 1.23A 4xe5A-5dlyA:
2.1		 4xe5A-5dlyA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmy BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		5 GLU A  79
GLU A  81
LEU A 597
GLY A 169
ALA A 335
 NI  A 904 (-2.8A)
NI  A 904 (-3.6A)
None
None
None
 1.14A 4xe5A-5dmyA:
undetectable		 4xe5A-5dmyA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eul AYC08
PROTEIN TRANSLOCASE
SUBUNIT SECY

(Geobacillus
thermodenitrificans;
Vicugna pacos) 		PF00344
(SecY)
PF07686
(V-set) 		5 GLU V  46
LEU Y 140
GLY V  35
PHE V  67
ASP V  89
 None
 1.05A 4xe5A-5eulV:
undetectable		 4xe5A-5eulV:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl3 PILI RETRACTION
PROTEIN PILT

(Thermus
thermophilus) 		PF00437
(T2SSE) 		5 GLU A 187
ASP A 191
GLU A 214
GLY A 198
ALA A 202
 None
 1.29A 4xe5A-5fl3A:
2.1		 4xe5A-5fl3A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gkv ESTERASE A

(Caulobacter
vibrioides) 		PF00144
(Beta-lactamase) 		5 GLU A 324
ASP A 339
GLU A 291
GLY A 327
ILE A 367
 None
 1.19A 4xe5A-5gkvA:
undetectable		 4xe5A-5gkvA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gm2 O-METHYLRANSFERASE

(Streptomyces
blastmyceticus) 		PF08241
(Methyltransf_11) 		5 GLU A 144
LEU A 177
GLY A 165
ALA A 163
ILE A  84
 None
 1.25A 4xe5A-5gm2A:
undetectable		 4xe5A-5gm2A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gui CHAPERONE PROTEIN
CLPC1, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF02861
(Clp_N) 		5 LEU A 202
GLU A 100
GLY A 136
ALA A 139
ILE A 131
 None
PO4  A 305 ( 4.4A)
PO4  A 301 (-3.3A)
None
None
 1.21A 4xe5A-5guiA:
undetectable		 4xe5A-5guiA:
11.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5he9 HELICASE LOADER

(Staphylococcus
aureus) 		PF01695
(IstB_IS21) 		5 GLU A 287
LEU A 270
GLY A 242
GLU A 230
ILE A 227
 None
 1.09A 4xe5A-5he9A:
undetectable		 4xe5A-5he9A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn8 ADENINE DNA
GLYCOSYLASE

(Geobacillus
stearothermophilus) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		5 GLU A 181
LEU A 134
ALA A 142
GLU A  43
ILE A 191
 None
 1.15A 4xe5A-5kn8A:
undetectable		 4xe5A-5kn8A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9s ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (MANNOPINE)

(Agrobacterium
fabrum) 		PF13416
(SBP_bac_8) 		5 GLN A 159
LEU A 146
GLY A 259
ALA A 248
ILE A 243
 ACT  A 401 ( 4.8A)
None
ACT  A 401 ( 3.9A)
None
None
 1.29A 4xe5A-5l9sA:
undetectable		 4xe5A-5l9sA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mfb YIII(DQ)4CQI

(synthetic
construct) 		PF00514
(Arm) 		5 GLU A 177
GLU A 170
GLY A 209
ALA A 207
ILE A 203
 None
 1.25A 4xe5A-5mfbA:
undetectable		 4xe5A-5mfbA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
ATP-BINDING SUBUNIT

(Escherichia
coli) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 LEU B 333
GLU B 406
ALA B 325
ILE B 323
ASP B 399
 None
 1.22A 4xe5A-5mrwB:
8.7		 4xe5A-5mrwB:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o25 TMPDE

(Thermotoga
maritima) 		no annotation 5 LEU A   8
GLU A 138
GLY A  36
PHE A 129
ILE A 102
 None
 1.14A 4xe5A-5o25A:
2.9		 4xe5A-5o25A:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2u CAPSID PROTEIN P24
VHH 59H10

(Human
immunodeficiency
virus 1;
Lama glama) 		PF00607
(Gag_p24)
PF07686
(V-set) 		5 GLU B  46
GLY B  35
GLU A 213
PHE B  67
ASP B  86
 None
 1.07A 4xe5A-5o2uB:
undetectable		 4xe5A-5o2uB:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3w PEPTIDE CYCLASE 1

(Gypsophila
vaccaria) 		no annotation 5 GLU A 583
GLU A 559
ALA A 541
PHE A 507
ILE A 512
 None
 1.26A 4xe5A-5o3wA:
2.9		 4xe5A-5o3wA:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vhj 26S PROTEASOME
REGULATORY SUBUNIT 7

(Homo sapiens) 		PF00004
(AAA) 		5 ASP A 325
LEU A 327
GLU A 276
GLY A 281
ALA A 283
 None
 1.24A 4xe5A-5vhjA:
2.8		 4xe5A-5vhjA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1j THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Echinococcus
granulosus) 		no annotation 5 ASP A 139
LEU A 137
GLU A 259
GLY A 120
ALA A 123
 FAD  A 601 (-3.0A)
None
None
FAD  A 601 (-3.7A)
None
 1.15A 4xe5A-5w1jA:
1.5		 4xe5A-5w1jA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcy GLUCANASE

(Phanerochaete
chrysosporium) 		PF01341
(Glyco_hydro_6) 		5 GLU A 214
ASP A 258
LEU A 294
ALA A 274
ASP A 170
 None
 1.04A 4xe5A-5xcyA:
undetectable		 4xe5A-5xcyA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
10, MITOCHONDRIAL

(Homo sapiens) 		PF06212
(GRIM-19) 		5 ASP w  63
GLY w  71
ALA w  74
ILE w  60
ASP w 166
 None
 1.07A 4xe5A-5xtdw:
undetectable		 4xe5A-5xtdw:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dch SCOE PROTEIN

(Streptomyces
coeruleorubidus) 		no annotation 5 GLU A 281
ASP A 284
GLU A 154
GLY A 158
ILE A  70
 None
 1.23A 4xe5A-6dchA:
undetectable		 4xe5A-6dchA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dch SCOE PROTEIN

(Streptomyces
coeruleorubidus) 		no annotation 5 GLU A 281
ASP A 284
LEU A 286
GLU A 154
GLY A 158
 None
 1.03A 4xe5A-6dchA:
undetectable		 4xe5A-6dchA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exs PEPTIDE ABC
TRANSPORTER PERMEASE

(Staphylococcus
hominis) 		no annotation 5 GLN A 344
GLU A 340
GLY A  42
GLU A  36
ILE A 129
 C3H  A 514 (-2.8A)
None
None
None
None
 1.27A 4xe5A-6exsA:
undetectable		 4xe5A-6exsA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhs RUVB-LIKE HELICASE

(Chaetomium
thermophilum) 		no annotation 5 ASP A 393
GLU A 371
GLY A 399
GLU A 435
ILE A 431
 None
 1.26A 4xe5A-6fhsA:
undetectable		 4xe5A-6fhsA:
6.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a40 PHOSPHATE-BINDING
PERIPLASMIC PROTEIN
PRECURSOR

(Escherichia
coli) 		PF12849
(PBP_like_2) 		4 PRO A  73
ILE A  76
VAL A  15
PHE A  11
 None
 0.99A 4xe5A-1a40A:
undetectable		 4xe5A-1a40A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE

(Human
alphaherpesvirus
2) 		PF00716
(Peptidase_S21) 		4 ILE A 121
VAL A  94
THR A 212
ARG A 226
 None
 1.17A 4xe5A-1at3A:
undetectable		 4xe5A-1at3A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb8 PROTEIN
(CHONDROITINASE AC)

(Pedobacter
heparinus) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 PRO A 410
ILE A 400
VAL A 290
ARG A 393
 None
 0.88A 4xe5A-1cb8A:
0.0		 4xe5A-1cb8A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpm GMP SYNTHETASE

(Escherichia
coli) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 ILE A  54
VAL A  23
PHE A 197
ARG A 174
 None
 0.88A 4xe5A-1gpmA:
2.6		 4xe5A-1gpmA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		4 ILE A 636
VAL A 625
PHE A 564
THR A 554
 None
 0.98A 4xe5A-1h7wA:
undetectable		 4xe5A-1h7wA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ILE A1063
VAL A1071
THR A1077
ARG A 793
 None
None
MTE  A3003 (-4.5A)
None
 0.96A 4xe5A-1n5xA:
0.0		 4xe5A-1n5xA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pmi PHOSPHOMANNOSE
ISOMERASE

(Candida
albicans) 		PF01238
(PMI_typeI) 		4 PRO A  96
PHE A 412
THR A  53
ARG A 436
 None
 1.11A 4xe5A-1pmiA:
undetectable		 4xe5A-1pmiA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pu7 3-METHYLADENINE DNA
GLYCOSYLASE

(Helicobacter
pylori) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		4 PRO A  86
VAL A  38
PHE A  45
THR A  43
 None
None
39A  A 219 (-3.5A)
None
 1.18A 4xe5A-1pu7A:
undetectable		 4xe5A-1pu7A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pv5 HYPOTHETICAL PROTEIN
YWQG

(Bacillus
subtilis) 		PF09234
(DUF1963) 		4 PRO A 155
ILE A 182
THR A 164
ARG A  12
 None
 1.16A 4xe5A-1pv5A:
undetectable		 4xe5A-1pv5A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpt PROSTATIC ACID
PHOSPHATASE

(Rattus
norvegicus) 		PF00328
(His_Phos_2) 		5 ILE A 235
VAL A 295
PHE A   5
THR A 243
ARG A 249
 None
 1.48A 4xe5A-1rptA:
undetectable		 4xe5A-1rptA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uag UDP-N-ACETYLMURAMOYL
-L-ALANINE/:D-GLUTAM
ATE LIGASE

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ILE A  68
VAL A  33
THR A  16
ARG A 100
 None
None
UMA  A 963 (-3.6A)
None
 1.17A 4xe5A-1uagA:
undetectable		 4xe5A-1uagA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2i RV0130

(Mycobacterium
tuberculosis) 		PF01575
(MaoC_dehydratas) 		4 PRO A  99
ILE A  44
VAL A  31
THR A  66
 None
 1.10A 4xe5A-2c2iA:
undetectable		 4xe5A-2c2iA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb0 GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Pyrococcus
furiosus) 		PF01380
(SIS) 		4 PRO A 293
PHE A 144
THR A 140
ARG A 151
 None
 1.13A 4xe5A-2cb0A:
4.1		 4xe5A-2cb0A:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chq REPLICATION FACTOR C
SMALL SUBUNIT

(Archaeoglobus
fulgidus) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 PRO A  13
ILE A  26
VAL A 161
PHE A 158
 ANP  A 700 (-4.0A)
None
None
None
 1.14A 4xe5A-2chqA:
2.4		 4xe5A-2chqA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5a LIPOYLTRANSFERASE 1

(Bos taurus) 		no annotation 4 PRO A  54
ILE A 246
THR A  79
ARG A  74
 None
 1.13A 4xe5A-2e5aA:
undetectable		 4xe5A-2e5aA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5f HYPOTHETICAL PROTEIN
PH0510

(Pyrococcus
horikoshii) 		PF01380
(SIS) 		4 PRO A 293
PHE A 144
THR A 140
ARG A 151
 None
 1.09A 4xe5A-2e5fA:
4.3		 4xe5A-2e5fA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9n EUKARYOTIC
INITIATION FACTOR
4A-I

(Homo sapiens) 		PF00270
(DEAD) 		4 PRO A  55
ILE A  30
VAL A 236
THR A  85
 MLY  A  54 ( 2.6A)
None
MLY  A 237 ( 3.0A)
MLY  A  82 ( 3.9A)
 1.09A 4xe5A-2g9nA:
undetectable		 4xe5A-2g9nA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmh ELECTRON TRANSFER
FLAVOPROTEIN-UBIQUIN
ONE OXIDOREDUCTASE

(Sus scrofa) 		PF05187
(ETF_QO)
PF13450
(NAD_binding_8) 		4 PRO A 512
ILE A 568
VAL A 532
PHE A 527
 None
None
SF4  A 610 ( 4.3A)
None
 1.19A 4xe5A-2gmhA:
2.9		 4xe5A-2gmhA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h18 ADP-RIBOSYLATION
FACTOR-LIKE PROTEIN
8A

(Homo sapiens) 		PF00025
(Arf) 		4 ILE A  67
VAL A  39
PHE A  16
THR A 173
 None
 1.08A 4xe5A-2h18A:
2.8		 4xe5A-2h18A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjr MALATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 PRO A 285
ILE A 298
VAL A 277
THR A 269
 None
 1.14A 4xe5A-2hjrA:
3.7		 4xe5A-2hjrA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5p GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
1

(Kluyveromyces
marxianus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ILE O 161
VAL O 262
PHE O 292
THR O 290
 None
 1.05A 4xe5A-2i5pO:
4.7		 4xe5A-2i5pO:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iny HEXON PROTEIN

(Fowl
aviadenovirus A) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 ILE A 107
VAL A 553
THR A  77
ARG A  71
 None
 1.17A 4xe5A-2inyA:
undetectable		 4xe5A-2inyA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 PRO X 348
ILE X 383
VAL X 395
THR X 130
 None
 1.19A 4xe5A-2iv2X:
4.7		 4xe5A-2iv2X:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjp CYTOCHROME P450
113A1

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		4 ILE A 111
VAL A 148
THR A 245
ARG A 364
 None
None
HEM  A 412 (-3.4A)
None
 1.18A 4xe5A-2jjpA:
undetectable		 4xe5A-2jjpA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jvn POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		PF08063
(PADR1) 		4 ILE A 248
VAL A 255
THR A 335
ARG A 282
 None
 0.81A 4xe5A-2jvnA:
undetectable		 4xe5A-2jvnA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n0s FE-HYDROGENASE

(Chlamydomonas
reinhardtii) 		PF02256
(Fe_hyd_SSU)
PF02906
(Fe_hyd_lg_C) 		4 ILE A 212
VAL A  55
THR A  62
ARG A 224
 None
 1.17A 4xe5A-2n0sA:
2.3		 4xe5A-2n0sA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nmp CYSTATHIONINE
GAMMA-LYASE

(Homo sapiens) 		PF01053
(Cys_Met_Meta_PP) 		4 PRO A 198
ILE A 167
VAL A 176
ARG A 305
 None
 1.12A 4xe5A-2nmpA:
1.8		 4xe5A-2nmpA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4a CLAVAMINATE
SYNTHASE-LIKE
PROTEIN AT3G21360

(Arabidopsis
thaliana) 		PF02668
(TauD) 		4 ILE A  47
VAL A  64
PHE A 134
ARG A 104
 None
 1.19A 4xe5A-2q4aA:
undetectable		 4xe5A-2q4aA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgs PROTEIN SE1688

(Staphylococcus
epidermidis) 		no annotation 4 ILE A   7
VAL A  93
PHE A  79
THR A  61
 None
 1.19A 4xe5A-2qgsA:
2.0		 4xe5A-2qgsA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzp ACYLAMINO-ACID-RELEA
SING ENZYME

(Aeropyrum
pernix) 		PF00326
(Peptidase_S9) 		4 PRO A 370
ILE A 412
VAL A 175
THR A 401
 None
 0.94A 4xe5A-2qzpA:
2.0		 4xe5A-2qzpA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 ILE G 101
VAL G 251
PHE G 137
ARG G 135
 None
 1.16A 4xe5A-2uv8G:
undetectable		 4xe5A-2uv8G:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		4 ILE A 295
VAL A 714
THR A 616
ARG A 309
 None
 1.06A 4xe5A-2xsgA:
undetectable		 4xe5A-2xsgA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z22 PERIPLASMIC
PHOSPHATE-BINDING
PROTEIN

(Yersinia pestis) 		no annotation 4 PRO X  73
ILE X  76
VAL X  15
PHE X  11
 None
 0.99A 4xe5A-2z22X:
undetectable		 4xe5A-2z22X:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq9 PREDICTED ROSSMANN
FOLD
NUCLEOTIDE-BINDING
DOMAIN-CONTAINING
PROTEIN

(Idiomarina
baltica) 		PF03641
(Lysine_decarbox)
PF11892
(DUF3412)
PF14793
(DUF4478) 		4 PRO A 252
ILE A 315
VAL A 321
THR A 163
 None
 1.10A 4xe5A-3bq9A:
undetectable		 4xe5A-3bq9A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6v PROBABLE
TAUTOMERASE/DEHALOGE
NASE AU4130

(Aspergillus
fumigatus) 		PF14832
(Tautomerase_3) 		4 ILE A  66
VAL A  39
PHE A  -2
ARG A  79
 None
 1.18A 4xe5A-3c6vA:
undetectable		 4xe5A-3c6vA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e96 DIHYDRODIPICOLINATE
SYNTHASE

(Bacillus
clausii) 		PF00701
(DHDPS) 		4 ILE A 170
VAL A 166
PHE A 203
THR A 212
 None
 1.14A 4xe5A-3e96A:
undetectable		 4xe5A-3e96A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez9 PARA

(Salmonella
enterica) 		PF13614
(AAA_31) 		4 ILE A 147
VAL A 136
THR A 386
ARG A 397
 None
 1.16A 4xe5A-3ez9A:
undetectable		 4xe5A-3ez9A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbk REGULATOR OF
G-PROTEIN SIGNALING
3

(Homo sapiens) 		PF00168
(C2) 		4 PRO A  95
ILE A 131
VAL A 116
THR A  86
 None
 0.89A 4xe5A-3fbkA:
undetectable		 4xe5A-3fbkA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdy UDP-GALACTOPYRANOSE
MUTASE

(Deinococcus
radiodurans) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		4 PRO A 298
ILE A 122
VAL A 163
THR A 180
 None
GDU  A 500 ( 4.3A)
None
GDU  A 500 (-3.2A)
 1.14A 4xe5A-3hdyA:
undetectable		 4xe5A-3hdyA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3o SHORT CHAIN
DEHYDROGENASE

(Bacillus
anthracis) 		PF13561
(adh_short_C2) 		4 ILE A 226
VAL A 247
PHE A 243
THR A   9
 NAE  A 311 (-4.4A)
None
NAE  A 311 (-4.8A)
None
 1.19A 4xe5A-3i3oA:
undetectable		 4xe5A-3i3oA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 ILE A 196
VAL A 203
PHE A 263
THR A 101
 None
 0.75A 4xe5A-3jxfA:
undetectable		 4xe5A-3jxfA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l22 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 PRO A 442
VAL A 191
THR A 448
ARG A 418
 ACT  A  12 (-3.9A)
None
None
None
 1.14A 4xe5A-3l22A:
undetectable		 4xe5A-3l22A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mxl NITROSOSYNTHASE

(Micromonospora
sp. ATCC 39149) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ILE A 255
VAL A  93
THR A 213
ARG A 364
 None
 1.13A 4xe5A-3mxlA:
undetectable		 4xe5A-3mxlA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Streptomyces
avermitilis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 PRO A  84
ILE A 156
VAL A 185
ARG A 278
 None
 1.10A 4xe5A-3n05A:
undetectable		 4xe5A-3n05A:
21.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 PRO A 118
ILE A 315
THR A 797
ARG A 880
 OBN  A   1 (-3.6A)
None
OBN  A   1 (-2.8A)
OBN  A   1 (-3.7A)
 1.05A 4xe5A-3n23A:
47.7		 4xe5A-3n23A:
95.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 PRO A 118
VAL A 322
PHE A 783
ARG A 880
 OBN  A   1 (-3.6A)
OBN  A   1 (-3.2A)
OBN  A   1 (-3.5A)
OBN  A   1 (-3.7A)
 1.18A 4xe5A-3n23A:
47.7		 4xe5A-3n23A:
95.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaa ATP SYNTHASE SUBUNIT
BETA

(Escherichia
coli) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 PRO D  23
VAL D   6
THR D  53
ARG D  37
 None
 1.06A 4xe5A-3oaaD:
undetectable		 4xe5A-3oaaD:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p94 GDSL-LIKE LIPASE

(Parabacteroides
distasonis) 		PF13472
(Lipase_GDSL_2) 		4 ILE A 222
VAL A  73
PHE A  66
THR A  56
 None
 1.03A 4xe5A-3p94A:
undetectable		 4xe5A-3p94A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFE

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro) 		4 ILE A 417
VAL A 327
PHE A 414
THR A 441
 None
 0.92A 4xe5A-3pdiA:
undetectable		 4xe5A-3pdiA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvu SULFOTRANSFERASE 1A1

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 PRO A  74
ILE A 243
PHE A  84
THR A  95
 None
 1.12A 4xe5A-3qvuA:
undetectable		 4xe5A-3qvuA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r2g INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE

(Legionella
pneumophila) 		PF00478
(IMPDH) 		4 ILE A 291
VAL A  45
PHE A  61
THR A  54
 None
 1.17A 4xe5A-3r2gA:
undetectable		 4xe5A-3r2gA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6b METHIONINE
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00557
(Peptidase_M24) 		4 PRO A 356
ILE A 214
VAL A 225
THR A 361
 None
 1.08A 4xe5A-3s6bA:
undetectable		 4xe5A-3s6bA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8d COENZYME A
TRANSFERASE

(Yersinia pestis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 ILE A  21
VAL A  57
THR A  69
ARG A  49
 None
 1.16A 4xe5A-3s8dA:
undetectable		 4xe5A-3s8dA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ILE C1063
VAL C1071
THR C1077
ARG C 793
 None
 0.92A 4xe5A-3sr6C:
undetectable		 4xe5A-3sr6C:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v6a APOPTOSIS INHIBITOR
5

(Homo sapiens) 		PF05918
(API5) 		4 ILE A 197
VAL A 171
PHE A 137
ARG A 148
 None
 1.09A 4xe5A-3v6aA:
undetectable		 4xe5A-3v6aA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v6a APOPTOSIS INHIBITOR
5

(Homo sapiens) 		PF05918
(API5) 		4 ILE A 197
VAL A 171
PHE A 137
THR A 132
 None
 1.13A 4xe5A-3v6aA:
undetectable		 4xe5A-3v6aA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3won DIPEPTIDYL
AMINOPEPTIDASE BII

(Pseudoxanthomonas
mexicana) 		PF10459
(Peptidase_S46) 		4 PRO A 273
ILE A 581
VAL A 661
THR A  71
 None
 1.18A 4xe5A-3wonA:
undetectable		 4xe5A-3wonA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq4 BETA-PRIMEVEROSIDASE

(Camellia
sinensis) 		PF00232
(Glyco_hydro_1) 		4 ILE A 302
VAL A 333
PHE A 337
THR A 200
 None
 1.18A 4xe5A-3wq4A:
undetectable		 4xe5A-3wq4A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3t DNA MISMATCH REPAIR
PROTEIN HSM3

(Saccharomyces
cerevisiae) 		no annotation 4 ILE A  29
VAL A  79
PHE A  61
THR A  57
 None
 1.13A 4xe5A-4a3tA:
undetectable		 4xe5A-4a3tA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4alq CHITIN BINDING
PROTEIN

(Enterococcus
faecalis) 		PF03067
(LPMO_10) 		4 ILE A 160
VAL A  32
THR A  97
ARG A 166
 None
 1.19A 4xe5A-4alqA:
undetectable		 4xe5A-4alqA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc4 NITRITE TRANSPORTER
NIRC

(Salmonella
enterica) 		PF01226
(Form_Nir_trans) 		4 ILE A  73
PHE A  86
THR A   5
ARG A  15
 None
 1.02A 4xe5A-4fc4A:
undetectable		 4xe5A-4fc4A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcy TRANSPOSASE

(Escherichia
virus Mu) 		PF02316
(HTH_Tnp_Mu_1)
PF02914
(DDE_2)
PF09039
(HTH_Tnp_Mu_2)
PF09299
(Mu-transpos_C) 		4 PRO A 328
ILE A 266
PHE A 468
ARG A 324
 None
 1.13A 4xe5A-4fcyA:
undetectable		 4xe5A-4fcyA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF13306
(LRR_5) 		4 PRO A  99
ILE A  29
VAL A  63
PHE A  87
 None
 1.05A 4xe5A-4fs7A:
undetectable		 4xe5A-4fs7A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ilr CRISPR-ASSOCIATED
ENDORIBONUCLEASE
CAS6 2

(Sulfolobus
solfataricus) 		PF10040
(CRISPR_Cas6) 		4 PRO A  20
ILE A  75
VAL A  11
THR A 105
 None
 1.18A 4xe5A-4ilrA:
undetectable		 4xe5A-4ilrA:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldc DOUBLE C2-LIKE
DOMAIN-CONTAINING
PROTEIN BETA

(Rattus
norvegicus) 		PF00168
(C2) 		4 PRO A 331
ILE A 367
VAL A 353
THR A 322
 None
 0.86A 4xe5A-4ldcA:
undetectable		 4xe5A-4ldcA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ngu TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Desulfovibrio
alaskensis) 		PF03480
(DctP) 		4 PRO A 220
ILE A 226
VAL A 205
THR A 163
 None
 0.97A 4xe5A-4nguA:
undetectable		 4xe5A-4nguA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov4 2-ISOPROPYLMALATE
SYNTHASE

(Leptospira
biflexa) 		PF00682
(HMGL-like) 		4 ILE A   8
VAL A 220
THR A 208
ARG A  97
 None
 1.18A 4xe5A-4ov4A:
undetectable		 4xe5A-4ov4A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p47 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ochrobactrum
anthropi) 		PF03480
(DctP) 		4 ILE A 312
PHE A 328
THR A 323
ARG A 335
 None
 1.18A 4xe5A-4p47A:
undetectable		 4xe5A-4p47A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4reg UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF01905
(DevR) 		5 PRO A  48
ILE A 148
VAL A  44
PHE A 282
ARG A   8
 None
 1.49A 4xe5A-4regA:
undetectable		 4xe5A-4regA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ruw ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE

(Beutenbergia
cavernae) 		PF03372
(Exo_endo_phos) 		4 ILE A 235
VAL A 217
PHE A 296
ARG A 265
 None
 1.12A 4xe5A-4ruwA:
undetectable		 4xe5A-4ruwA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ts6 RAB3 INTERACTING
MOLECULE VARIANT 2

(Drosophila
melanogaster) 		PF00168
(C2) 		4 PRO A 903
ILE A 940
VAL A 926
THR A 894
 None
 0.89A 4xe5A-4ts6A:
undetectable		 4xe5A-4ts6A:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uuu CYSTATHIONINE
BETA-SYNTHASE

(Homo sapiens) 		PF00571
(CBS) 		4 PRO A 422
ILE A 455
VAL A 459
PHE A 487
 SAM  A1546 (-4.7A)
None
None
None
 1.04A 4xe5A-4uuuA:
undetectable		 4xe5A-4uuuA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v11 SYNAPTOTAGMIN-1

(Homo sapiens) 		PF00168
(C2) 		4 PRO A 338
ILE A 374
VAL A 360
THR A 329
 None
 0.83A 4xe5A-4v11A:
undetectable		 4xe5A-4v11A:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr3 ALANINE RACEMASE,
BIOSYNTHETIC

(Escherichia
coli) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 PRO A 219
ILE A 197
VAL A  32
ARG A  19
 None
None
PLP  A1001 ( 4.6A)
None
 1.17A 4xe5A-4wr3A:
undetectable		 4xe5A-4wr3A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus AP22) 		no annotation 4 PRO A 483
ILE A 510
VAL A 576
ARG A 472
 None
 1.07A 4xe5A-4y9vA:
undetectable		 4xe5A-4y9vA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ILE A 127
VAL A 572
PHE A 698
THR A 675
 None
 0.97A 4xe5A-5a7mA:
4.8		 4xe5A-5a7mA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwe BENZYLSUCCINATE
SYNTHASE BETA CHAIN

(Thauera
aromatica) 		no annotation 4 PRO B  36
VAL B  54
THR B  33
ARG B  60
 None
 1.19A 4xe5A-5bweB:
undetectable		 4xe5A-5bweB:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		4 ILE A 217
VAL A 224
PHE A 284
THR A 123
 None
 0.90A 4xe5A-5e5uA:
undetectable		 4xe5A-5e5uA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		4 PRO A 251
ILE A 144
VAL A 260
THR A 274
 None
 0.84A 4xe5A-5ej1A:
undetectable		 4xe5A-5ej1A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffj ENDONUCLEASE AND
METHYLASE LLAGI

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII) 		4 PRO A 903
ILE A1081
VAL A1084
ARG A1069
 None
 1.12A 4xe5A-5ffjA:
1.6		 4xe5A-5ffjA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fya PATATIN-LIKE
PROTEIN, PLPD

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		4 VAL A 206
PHE A 176
THR A  59
ARG A 177
 None
 1.18A 4xe5A-5fyaA:
undetectable		 4xe5A-5fyaA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzp TRIOSEPHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF00121
(TIM) 		4 ILE A 206
VAL A 151
PHE A 127
THR A 144
 None
 0.88A 4xe5A-5gzpA:
undetectable		 4xe5A-5gzpA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb5 NUCLEOPORIN NUP145

(Chaetomium
thermophilum) 		PF04096
(Nucleoporin2) 		4 ILE A  56
VAL A  36
PHE A  26
ARG A  20
 None
 1.01A 4xe5A-5hb5A:
undetectable		 4xe5A-5hb5A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i84 PHOSPHATE-BINDING
PROTEIN PSTS

(Xanthomonas
citri) 		PF12849
(PBP_like_2) 		4 PRO A  97
ILE A 100
VAL A  39
PHE A  35
 None
 1.12A 4xe5A-5i84A:
undetectable		 4xe5A-5i84A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixd TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 4 ILE A 384
VAL A 381
PHE A 405
THR A 288
 None
 1.18A 4xe5A-5ixdA:
undetectable		 4xe5A-5ixdA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale) 		PF07992
(Pyr_redox_2) 		4 PRO A 211
ILE A 307
VAL A 215
THR A 191
 None
 1.15A 4xe5A-5m10A:
undetectable		 4xe5A-5m10A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mbh BETA SUBUNIT OF
PHOTOACTIVATED
ADENYLYL CYCLASE

(Beggiatoa sp.
PS) 		PF00211
(Guanylate_cyc)
PF04940
(BLUF) 		4 ILE A 199
VAL A 195
PHE A 155
ARG A 278
 None
 1.14A 4xe5A-5mbhA:
undetectable		 4xe5A-5mbhA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr7 GRAINYHEAD-LIKE
PROTEIN 2 HOMOLOG

(Homo sapiens) 		no annotation 4 ILE A 393
PHE A 357
THR A 343
ARG A 297
 None
 1.07A 4xe5A-5mr7A:
undetectable		 4xe5A-5mr7A:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrt LYTIC ENDOPEPTIDASE
PREPROENZYME

(Lysobacter sp.
XL1) 		no annotation 4 PRO A  26
ILE A   7
VAL A  48
ARG A 107
 None
 0.94A 4xe5A-5mrtA:
undetectable		 4xe5A-5mrtA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		4 ILE A 310
VAL A 358
PHE A 363
THR A 365
 None
None
None
FMT  A 510 ( 4.8A)
 1.07A 4xe5A-5v0tA:
undetectable		 4xe5A-5v0tA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9x ATP-DEPENDENT DNA
HELICASE

(Mycolicibacterium
smegmatis) 		no annotation 4 ILE A 416
VAL A 241
PHE A 636
ARG A 630
 None
 1.19A 4xe5A-5v9xA:
undetectable		 4xe5A-5v9xA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v9x ATP-DEPENDENT DNA
HELICASE

(Mycolicibacterium
smegmatis) 		no annotation 4 PRO A 139
ILE A 143
VAL A 167
PHE A  59
 None
 1.19A 4xe5A-5v9xA:
undetectable		 4xe5A-5v9xA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 4 ILE A 157
VAL A 477
PHE A 274
THR A 422
 None
 1.13A 4xe5A-5xqoA:
undetectable		 4xe5A-5xqoA:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ysb LIN1841 PROTEIN

(Listeria
innocua) 		no annotation 4 PRO A 194
ILE A 236
VAL A 229
THR A 199
 None
 1.11A 4xe5A-5ysbA:
undetectable		 4xe5A-5ysbA:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b8a DNA-BINDING
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		no annotation 4 ILE A 147
VAL A 122
PHE A 284
ARG A 289
 None
 1.19A 4xe5A-6b8aA:
undetectable		 4xe5A-6b8aA:
6.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhq IGH PROTEIN

(Mus musculus) 		no annotation 4 PRO A 374
ILE A 247
VAL A 379
THR A 396
 None
 1.14A 4xe5A-6bhqA:
undetectable		 4xe5A-6bhqA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6chd LYSINE--TRNA LIGASE

(Homo sapiens) 		no annotation 4 ILE A 353
PHE A 486
THR A 500
ARG A 393
 None
 1.17A 4xe5A-6chdA:
undetectable		 4xe5A-6chdA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza

() 		no annotation 4 PRO B 184
ILE A 229
VAL A 745
PHE B 228
 SF4  B 301 ( 4.8A)
None
None
None
 1.13A 4xe5A-6czaB:
undetectable		 4xe5A-6czaB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44

(Homo sapiens) 		no annotation 4 PRO K 375
ILE K 402
VAL K 417
ARG K 384
 A  O  51 ( 4.5A)
None
None
A  O  48 ( 3.6A)
 1.13A 4xe5A-6d6qK:
undetectable		 4xe5A-6d6qK:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza B
virus) 		no annotation 4 ILE B 248
VAL B 254
PHE B 413
THR B 322
 None
 1.09A 4xe5A-6f5oB:
undetectable		 4xe5A-6f5oB:
6.56