SIMILAR PATTERNS OF AMINO ACIDS FOR 4XE3_B_CL6B502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2z PYRROLIDONE CARBOXYL
PEPTIDASE

(Thermococcus
litoralis) 		PF01470
(Peptidase_C15) 		4 LEU A  42
ALA A  24
VAL A  65
ILE A  66
 None
 0.86A 4xe3B-1a2zA:
0.0		 4xe3B-1a2zA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a99 PUTRESCINE-BINDING
PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		4 LEU A 299
THR A  53
VAL A  57
ILE A  55
 None
 0.85A 4xe3B-1a99A:
0.0		 4xe3B-1a99A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdm MALATE DEHYDROGENASE

(Thermus
thermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A  84
ALA A  80
VAL A  35
ILE A  36
 None
 0.96A 4xe3B-1bdmA:
0.0		 4xe3B-1bdmA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e2z CYTOCHROME F

(Chlamydomonas
reinhardtii) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		4 LEU A 113
ALA A  47
VAL A  89
ILE A  93
 None
 0.94A 4xe3B-1e2zA:
0.0		 4xe3B-1e2zA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE

(Streptomyces
antibioticus) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03726
(PNPase) 		4 ALA A 219
THR A 209
VAL A 438
ILE A 210
 None
 0.94A 4xe3B-1e3hA:
0.0		 4xe3B-1e3hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE

(Streptomyces
antibioticus) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03726
(PNPase) 		4 ALA A 486
THR A 471
VAL A 438
ILE A 435
 None
 0.94A 4xe3B-1e3hA:
0.0		 4xe3B-1e3hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e59 PHOSPHOGLYCERATE
MUTASE

(Escherichia
coli) 		PF00300
(His_Phos_1) 		4 LEU A 190
ALA A 182
VAL A 178
ILE A 179
 None
 0.80A 4xe3B-1e59A:
0.0		 4xe3B-1e59A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvy THYMIDYLATE SYNTHASE

(Homo sapiens) 		PF00303
(Thymidylat_synt) 		4 ALA A 238
THR A 241
VAL A 164
ILE A 165
 None
None
BME  A1514 (-4.3A)
None
 0.91A 4xe3B-1hvyA:
0.0		 4xe3B-1hvyA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iir GLYCOSYLTRANSFERASE
GTFB

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		4 LEU A  17
ALA A  35
VAL A 109
ILE A  87
 None
 0.87A 4xe3B-1iirA:
0.0		 4xe3B-1iirA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j33 COBT

(Thermus
thermophilus) 		PF02277
(DBI_PRT) 		4 LEU A 230
ALA A  54
THR A  71
ILE A 165
 None
 0.96A 4xe3B-1j33A:
0.0		 4xe3B-1j33A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka0 HALOTOLERANCE
PROTEIN HAL2

(Saccharomyces
cerevisiae) 		PF00459
(Inositol_P) 		4 ALA A  52
THR A  21
VAL A  28
ILE A  24
 None
 0.90A 4xe3B-1ka0A:
undetectable		 4xe3B-1ka0A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		4 LEU A  17
ALA A 407
VAL A  65
ILE A 401
 None
 0.96A 4xe3B-1kcxA:
undetectable		 4xe3B-1kcxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krm ADENOSINE DEAMINASE

(Bos taurus) 		PF00962
(A_deaminase) 		4 LEU A 104
ALA A  75
THR A  23
ILE A  24
 None
 0.93A 4xe3B-1krmA:
undetectable		 4xe3B-1krmA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lml LEISHMANOLYSIN

(Leishmania
major) 		PF01457
(Peptidase_M8) 		4 LEU A 365
ALA A 360
VAL A 322
ILE A 335
 None
 0.95A 4xe3B-1lmlA:
undetectable		 4xe3B-1lmlA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		4 LEU A 223
ALA A 403
THR A 405
ILE A 214
 None
 0.89A 4xe3B-1lnsA:
undetectable		 4xe3B-1lnsA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0u GST2 GENE PRODUCT

(Drosophila
melanogaster) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 LEU A  67
ALA A 203
VAL A 138
ILE A 141
 None
 0.84A 4xe3B-1m0uA:
undetectable		 4xe3B-1m0uA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdw CALPAIN II,
CATALYTIC SUBUNIT

(Rattus
norvegicus) 		PF00648
(Peptidase_C2) 		4 LEU A 107
ALA A 112
THR A 115
VAL A 124
 None
 0.95A 4xe3B-1mdwA:
undetectable		 4xe3B-1mdwA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mkb BETA-HYDROXYDECANOYL
THIOL ESTER
DEHYDRASE

(Escherichia
coli) 		PF07977
(FabA) 		4 LEU A  28
ALA A  85
VAL A  54
ILE A 128
 None
 0.95A 4xe3B-1mkbA:
undetectable		 4xe3B-1mkbA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzj HYPOTHETICAL PROTEIN
YADB

(Escherichia
coli) 		PF00749
(tRNA-synt_1c) 		4 LEU A  23
ALA A 249
VAL A 267
ILE A 270
 None
 0.84A 4xe3B-1nzjA:
undetectable		 4xe3B-1nzjA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orf GRANZYME A

(Homo sapiens) 		PF00089
(Trypsin) 		4 LEU A 108
ALA A  48
VAL A 118
ILE A 114
 None
 0.93A 4xe3B-1orfA:
undetectable		 4xe3B-1orfA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osn THYMIDINE KINASE

(Human
alphaherpesvirus
3) 		PF00693
(Herpes_TK) 		4 LEU A  73
ALA A  82
THR A  86
ILE A  65
 None
None
None
BVP  A 500 ( 4.2A)
 0.92A 4xe3B-1osnA:
undetectable		 4xe3B-1osnA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3h DEPHOSPHO-COA KINASE

(Escherichia
coli) 		PF01121
(CoaE) 		4 LEU A 115
ALA A  32
THR A  96
ILE A 100
 None
 0.90A 4xe3B-1t3hA:
undetectable		 4xe3B-1t3hA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ARP2/3 COMPLEX 16KDA
SUBUNIT
ARP2/3 COMPLEX 20KDA
SUBUNIT

(Bos taurus) 		PF04699
(P16-Arc)
PF05856
(ARPC4) 		5 LEU G 125
ALA F  11
THR F  15
VAL G 144
ILE G 141
 None
 1.00A 4xe3B-1u2vG:
undetectable		 4xe3B-1u2vG:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urd MALTOSE-BINDING
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF01547
(SBP_bac_1) 		4 LEU A 372
ALA A 386
VAL A 192
ILE A 205
 None
 0.95A 4xe3B-1urdA:
undetectable		 4xe3B-1urdA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vec ATP-DEPENDENT RNA
HELICASE P54

(Homo sapiens) 		PF00270
(DEAD) 		4 LEU A 140
ALA A 156
VAL A 160
ILE A 159
 None
 0.95A 4xe3B-1vecA:
undetectable		 4xe3B-1vecA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE

(Aeropyrum
pernix) 		PF00793
(DAHP_synth_1) 		4 LEU A 266
ALA A  43
VAL A 212
ILE A 211
 None
 0.88A 4xe3B-1vs1A:
undetectable		 4xe3B-1vs1A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdi RV3303C-LPDA

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A   8
THR A 307
VAL A 289
ILE A 291
 FAD  A 999 ( 4.8A)
None
None
None
 0.91A 4xe3B-1xdiA:
undetectable		 4xe3B-1xdiA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		no annotation 4 LEU B 291
ALA B 353
VAL B 369
ILE B 366
 None
 0.95A 4xe3B-1xnjB:
undetectable		 4xe3B-1xnjB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqp 8-OXOGUANINE DNA
GLYCOSYLASE

(Pyrobaculum
aerophilum) 		PF09171
(AGOG) 		4 ALA A 207
THR A 210
VAL A  10
ILE A  11
 None
 0.82A 4xe3B-1xqpA:
undetectable		 4xe3B-1xqpA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrv UBIQUITIN-CONJUGATIN
G LIGASE MGC351130

(Homo sapiens) 		PF00179
(UQ_con) 		4 LEU A  93
ALA A 111
VAL A  38
ILE A  40
 None
 0.73A 4xe3B-1yrvA:
undetectable		 4xe3B-1yrvA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		4 LEU A 243
ALA A 248
THR A 251
ILE A 201
 None
 0.97A 4xe3B-1zklA:
undetectable		 4xe3B-1zklA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		4 ALA A 239
THR A 242
VAL A 156
ILE A 157
 None
 0.79A 4xe3B-2aazA:
undetectable		 4xe3B-2aazA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aip PROTEIN C ACTIVATOR

(Agkistrodon
contortrix) 		PF00089
(Trypsin) 		4 LEU A  41
ALA A 149
THR A 145
ILE A  17
 None
 0.94A 4xe3B-2aipA:
undetectable		 4xe3B-2aipA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aw5 NADP-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		4 LEU A 312
ALA A 279
VAL A 461
ILE A 513
 None
 0.97A 4xe3B-2aw5A:
undetectable		 4xe3B-2aw5A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cf5 CINNAMYL ALCOHOL
DEHYDROGENASE

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 224
THR A 251
VAL A 168
ILE A 249
 None
 0.84A 4xe3B-2cf5A:
undetectable		 4xe3B-2cf5A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE

(Thermus
thermophilus) 		PF01966
(HD)
PF13286
(HD_assoc) 		4 LEU A 296
ALA A 258
VAL A  86
ILE A  90
 None
 0.71A 4xe3B-2dqbA:
undetectable		 4xe3B-2dqbA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzd PYRUVATE CARBOXYLASE

(Geobacillus
thermodenitrificans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LEU A 146
ALA A 151
VAL A 176
ILE A 160
 None
 0.96A 4xe3B-2dzdA:
undetectable		 4xe3B-2dzdA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2euh NADP DEPENDENT NON
PHOSPHORYLATING
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Streptococcus
mutans) 		PF00171
(Aldedh) 		4 ALA A 160
THR A 104
VAL A  71
ILE A 108
 None
 0.86A 4xe3B-2euhA:
undetectable		 4xe3B-2euhA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyw V-CRK SARCOMA VIRUS
CT10 ONCOGENE
HOMOLOG ISOFORM A

(Homo sapiens) 		PF00018
(SH3_1) 		4 LEU A 159
ALA A 172
VAL A 184
ILE A 182
 None
 0.95A 4xe3B-2eywA:
undetectable		 4xe3B-2eywA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		4 LEU A 211
ALA A 257
VAL A 232
ILE A 264
 None
 0.94A 4xe3B-2gouA:
undetectable		 4xe3B-2gouA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjr MALATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A  58
ALA A  22
THR A  89
ILE A  87
 None
None
APR  A3001 (-4.9A)
None
 0.87A 4xe3B-2hjrA:
undetectable		 4xe3B-2hjrA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		4 LEU A 517
ALA A 502
THR A 497
ILE A 495
 None
 0.95A 4xe3B-2hnzA:
undetectable		 4xe3B-2hnzA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ALA A 396
THR A 399
VAL A 302
ILE A 456
 None
 0.86A 4xe3B-2iwzA:
undetectable		 4xe3B-2iwzA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l26 UNCHARACTERIZED
PROTEIN
RV0899/MT0922

(Mycobacterium
tuberculosis) 		PF00691
(OmpA)
PF04972
(BON) 		4 LEU A 300
ALA A 278
VAL A 324
ILE A 323
 None
 0.93A 4xe3B-2l26A:
undetectable		 4xe3B-2l26A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjd RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE C

(Escherichia
coli) 		PF05175
(MTS)
PF08468
(MTS_N) 		4 LEU A 188
ALA A 213
VAL A 200
ILE A 221
 None
 0.86A 4xe3B-2pjdA:
undetectable		 4xe3B-2pjdA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5e CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 2

(Homo sapiens) 		PF03031
(NIF) 		4 LEU A 108
ALA A 167
VAL A 127
ILE A 129
 None
 0.81A 4xe3B-2q5eA:
undetectable		 4xe3B-2q5eA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjf BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A 291
ALA A 353
VAL A 369
ILE A 366
 None
 0.88A 4xe3B-2qjfA:
undetectable		 4xe3B-2qjfA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qup BH1478 PROTEIN

(Bacillus
halodurans) 		PF03885
(DUF327) 		4 LEU A  43
ALA A 145
VAL A 105
ILE A 104
 None
 0.86A 4xe3B-2qupA:
undetectable		 4xe3B-2qupA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2raf PUTATIVE
DINUCLEOTIDE-BINDING
OXIDOREDUCTASE

(Lactobacillus
plantarum) 		PF03807
(F420_oxidored) 		5 LEU A  98
ALA A  91
THR A  71
VAL A  46
ILE A  70
 None
None
NAP  A 200 ( 4.2A)
NAP  A 200 ( 4.1A)
NAP  A 200 ( 4.3A)
 1.40A 4xe3B-2rafA:
undetectable		 4xe3B-2rafA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		4 LEU A  82
ALA A  89
VAL A 338
ILE A 342
 None
 0.92A 4xe3B-2vz9A:
undetectable		 4xe3B-2vz9A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115

(Homo sapiens) 		PF04869
(Uso1_p115_head) 		4 ALA A 327
THR A 331
VAL A 385
ILE A 334
 None
 0.77A 4xe3B-2w3cA:
undetectable		 4xe3B-2w3cA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsz RUVB-LIKE 1

(Homo sapiens) 		PF06068
(TIP49) 		4 LEU A  38
ALA A  98
VAL A  80
ILE A 237
 None
 0.95A 4xe3B-2xszA:
undetectable		 4xe3B-2xszA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3awd PUTATIVE POLYOL
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF13561
(adh_short_C2) 		4 ALA A  93
THR A  16
VAL A  78
ILE A  14
 None
 0.96A 4xe3B-3awdA:
undetectable		 4xe3B-3awdA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3br8 PROBABLE
ACYLPHOSPHATASE

(Bacillus
subtilis) 		PF00708
(Acylphosphatase) 		4 LEU A  30
ALA A  59
VAL A  74
ILE A  72
 None
 0.90A 4xe3B-3br8A:
undetectable		 4xe3B-3br8A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czb PUTATIVE
TRANSGLYCOSYLASE

(Caulobacter
vibrioides) 		PF03562
(MltA)
PF06725
(3D) 		4 LEU A 332
ALA A 135
VAL A 319
ILE A 359
 None
 0.87A 4xe3B-3czbA:
undetectable		 4xe3B-3czbA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5t MALATE DEHYDROGENASE

(Burkholderia
pseudomallei) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A  86
ALA A  82
VAL A  37
ILE A  38
 None
 0.90A 4xe3B-3d5tA:
undetectable		 4xe3B-3d5tA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5

(Schizosaccharomyces
pombe) 		PF04699
(P16-Arc)
PF05856
(ARPC4) 		4 LEU G 126
ALA F  11
THR F  15
VAL G 145
 None
 0.94A 4xe3B-3dwlG:
undetectable		 4xe3B-3dwlG:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5

(Schizosaccharomyces
pombe) 		PF04699
(P16-Arc)
PF05856
(ARPC4) 		4 LEU G 126
THR F  15
VAL G 145
ILE G 142
 None
 0.90A 4xe3B-3dwlG:
undetectable		 4xe3B-3dwlG:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0x LIPASE-ESTERASE
RELATED PROTEIN

(Clostridium
acetobutylicum) 		PF12146
(Hydrolase_4) 		4 LEU A 181
ALA A  99
VAL A  60
ILE A  64
 None
 0.89A 4xe3B-3e0xA:
undetectable		 4xe3B-3e0xA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7w D-ALANINE--POLY(PHOS
PHORIBITOL) LIGASE
SUBUNIT 1

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 127
ALA A  40
VAL A  57
ILE A  55
 None
 0.90A 4xe3B-3e7wA:
undetectable		 4xe3B-3e7wA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		4 ALA A 363
THR A 339
VAL A 423
ILE A 424
 None
 0.95A 4xe3B-3gcwA:
undetectable		 4xe3B-3gcwA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq2 GENERAL VESICULAR
TRANSPORT FACTOR
P115

(Bos taurus) 		PF04869
(Uso1_p115_head) 		4 ALA A 327
THR A 331
VAL A 385
ILE A 334
 None
 0.85A 4xe3B-3gq2A:
undetectable		 4xe3B-3gq2A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwb PEPTIDASE M16
INACTIVE DOMAIN
FAMILY PROTEIN

(Pseudomonas
protegens) 		PF05193
(Peptidase_M16_C) 		4 LEU A  63
ALA A  90
VAL A 197
ILE A  41
 None
 0.91A 4xe3B-3gwbA:
undetectable		 4xe3B-3gwbA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyf REVERSE
TRANSCRIPTASE/RNASEH

(Escherichia
coli;
Human
immunodeficiency
virus 1) 		PF00075
(RNase_H) 		4 LEU A 517
ALA A 502
THR A 497
ILE A 495
 None
 0.95A 4xe3B-3hyfA:
undetectable		 4xe3B-3hyfA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifr CARBOHYDRATE KINASE,
FGGY

(Rhodospirillum
rubrum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LEU A 424
ALA A 406
VAL A 273
ILE A 255
 None
 0.64A 4xe3B-3ifrA:
undetectable		 4xe3B-3ifrA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij6 UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Lactobacillus
acidophilus) 		PF04909
(Amidohydro_2) 		4 LEU A  60
ALA A  99
VAL A 114
ILE A 118
 None
 0.86A 4xe3B-3ij6A:
undetectable		 4xe3B-3ij6A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2p REVERSE
TRANSCRIPTASE

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H) 		4 LEU A 517
ALA A 502
THR A 497
ILE A 495
 None
 0.90A 4xe3B-3k2pA:
undetectable		 4xe3B-3k2pA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n92 ALPHA-AMYLASE, GH57
FAMILY

(Thermococcus
kodakarensis) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 LEU A 461
ALA A 431
VAL A 439
ILE A 438
 None
 0.88A 4xe3B-3n92A:
undetectable		 4xe3B-3n92A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nku DRRA

(Legionella
pneumophila) 		no annotation 4 LEU A 192
ALA A 113
VAL A 126
ILE A 160
 None
 0.92A 4xe3B-3nkuA:
undetectable		 4xe3B-3nkuA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oei RELK (TOXIN RV3358)

(Mycobacterium
tuberculosis) 		PF06769
(YoeB_toxin) 		4 LEU C  15
ALA C  25
THR C  29
ILE C  32
 None
 0.75A 4xe3B-3oeiC:
undetectable		 4xe3B-3oeiC:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pft FLAVIN REDUCTASE

(Mycolicibacterium
goodii) 		PF01613
(Flavin_Reduct) 		4 LEU A  98
ALA A  26
VAL A  22
ILE A  23
 None
 0.89A 4xe3B-3pftA:
undetectable		 4xe3B-3pftA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q62 3-HYDROXYDECANOYL-[A
CYL-CARRIER-PROTEIN]
DEHYDRATASE

(Yersinia pestis) 		PF07977
(FabA) 		4 LEU A  29
ALA A  86
VAL A  55
ILE A 129
 None
 0.91A 4xe3B-3q62A:
undetectable		 4xe3B-3q62A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdq 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Clostridium
aminobutyricum) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 ALA A  30
THR A 141
VAL A 168
ILE A 145
 None
 0.91A 4xe3B-3qdqA:
undetectable		 4xe3B-3qdqA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Sorangium
cellulosum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A  92
ALA A  69
VAL A  38
ILE A  12
 None
 0.81A 4xe3B-3s5sA:
undetectable		 4xe3B-3s5sA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgg HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF14323
(GxGYxYP_C)
PF16216
(GxGYxYP_N) 		4 LEU A 179
ALA A 174
VAL A 134
ILE A 143
 None
 0.94A 4xe3B-3sggA:
undetectable		 4xe3B-3sggA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdf DIHYDRODIPICOLINATE
SYNTHASE

(Acinetobacter
baumannii) 		PF00701
(DHDPS) 		5 LEU A 256
ALA A 207
THR A  36
VAL A  28
ILE A  39
 None
 1.49A 4xe3B-3tdfA:
undetectable		 4xe3B-3tdfA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		4 LEU A  60
ALA A  74
VAL A 123
ILE A  82
 None
 0.88A 4xe3B-3tfoA:
undetectable		 4xe3B-3tfoA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4c ALDEHYDE
DEHYDROGENASE
(NADP+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 LEU A 108
ALA A 197
VAL A 211
ILE A 202
 None
 0.97A 4xe3B-3v4cA:
undetectable		 4xe3B-3v4cA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4r CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		4 LEU A 172
ALA A 187
VAL A 102
ILE A  58
 None
 0.95A 4xe3B-3w4rA:
undetectable		 4xe3B-3w4rA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waf IRON ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING PROTEIN

(Thermus
thermophilus) 		PF13416
(SBP_bac_8) 		4 LEU A 269
THR A  46
VAL A  50
ILE A  48
 None
 0.81A 4xe3B-3wafA:
undetectable		 4xe3B-3wafA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wky PROPHENOLOXIDASE B

(Marsupenaeus
japonicus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 LEU A  57
ALA A 115
THR A 119
ILE A  88
 None
 0.96A 4xe3B-3wkyA:
undetectable		 4xe3B-3wkyA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl1 CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		4 LEU A 172
ALA A 187
VAL A 102
ILE A  58
 None
 0.93A 4xe3B-3wl1A:
undetectable		 4xe3B-3wl1A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		4 LEU B 465
ALA B 485
VAL B  24
ILE B  27
 None
 0.94A 4xe3B-3ze7B:
undetectable		 4xe3B-3ze7B:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx2 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 1

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		4 ALA A  95
THR A  98
VAL A 152
ILE A 101
 None
 0.93A 4xe3B-3zx2A:
undetectable		 4xe3B-3zx2A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bej DYNAMIN 1-LIKE
PROTEIN

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 LEU A  67
ALA A 286
THR A 282
VAL A 258
ILE A 262
 None
 1.15A 4xe3B-4bejA:
3.7		 4xe3B-4bejA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE

(Methanocaldococcus
jannaschii) 		PF00464
(SHMT) 		4 LEU A 213
ALA A  86
VAL A 100
ILE A 246
 None
 0.95A 4xe3B-4bhdA:
undetectable		 4xe3B-4bhdA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c60 OCHRATOXINASE

(Aspergillus
niger) 		PF01979
(Amidohydro_1) 		4 LEU A 305
ALA A 249
VAL A 274
ILE A 273
 None
 0.90A 4xe3B-4c60A:
undetectable		 4xe3B-4c60A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA

(Methanothermobacter
marburgensis) 		PF04422
(FrhB_FdhB_N)
PF04432
(FrhB_FdhB_C) 		4 LEU C 128
ALA C 203
VAL C 219
ILE C 220
 None
 0.97A 4xe3B-4ci0C:
undetectable		 4xe3B-4ci0C:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxk ARYLSULFATASE

(Pseudomonas
aeruginosa) 		PF00884
(Sulfatase) 		4 LEU A 116
ALA A  96
THR A 411
VAL A 407
 None
 0.96A 4xe3B-4cxkA:
undetectable		 4xe3B-4cxkA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dio NAD(P)
TRANSHYDROGENASE
SUBUNIT ALPHA PART 1

(Sinorhizobium
meliloti) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		4 LEU A 238
ALA A 204
THR A 288
ILE A 286
 None
 0.96A 4xe3B-4dioA:
undetectable		 4xe3B-4dioA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Borreliella
burgdorferi) 		PF00300
(His_Phos_1) 		4 LEU A 194
ALA A 186
VAL A 182
ILE A 183
 None
 0.88A 4xe3B-4embA:
undetectable		 4xe3B-4embA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emy AMINOTRANSFERASE
CLASS I AND II

(Anaerococcus
prevotii) 		PF00155
(Aminotran_1_2) 		4 LEU A 399
ALA A 404
THR A 407
ILE A 366
 None
 0.96A 4xe3B-4emyA:
undetectable		 4xe3B-4emyA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grs PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE,
2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus;
Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		4 LEU A 322
ALA A  99
VAL A 268
ILE A 267
 None
 0.96A 4xe3B-4grsA:
undetectable		 4xe3B-4grsA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsc STREPTOLYSIN O

(Streptococcus
pyogenes) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		4 LEU X 278
ALA X 296
VAL X 415
ILE X 416
 None
 0.91A 4xe3B-4hscX:
undetectable		 4xe3B-4hscX:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3u ALDEHYDE
DEHYDROGENASE (NAD+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 LEU A  80
ALA A 200
VAL A 168
ILE A 172
 None
 0.92A 4xe3B-4i3uA:
undetectable		 4xe3B-4i3uA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ife GENE 2 PROTEIN

(Shigella virus
Sf6) 		PF04466
(Terminase_3)
PF17288
(Terminase_3C) 		4 LEU A 403
ALA A 408
THR A 411
ILE A 216
 None
 0.94A 4xe3B-4ifeA:
undetectable		 4xe3B-4ifeA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf7 NUP188

(Thermothelomyces
thermophila) 		PF10487
(Nup188) 		4 LEU A 819
ALA A 869
VAL A 915
ILE A 919
 None
 0.88A 4xe3B-4kf7A:
undetectable		 4xe3B-4kf7A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY

(Thermococcus
kodakarensis) 		PF00375
(SDF) 		4 LEU A  68
THR A 413
VAL A  83
ILE A  87
 None
 0.88A 4xe3B-4ky0A:
1.2		 4xe3B-4ky0A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		4 LEU A  79
ALA A 333
VAL A 128
ILE A 339
 None
 0.95A 4xe3B-4lvqA:
undetectable		 4xe3B-4lvqA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		4 LEU A  79
THR A 364
VAL A 128
ILE A 339
 None
 0.82A 4xe3B-4lvqA:
undetectable		 4xe3B-4lvqA:
22.07