SIMILAR PATTERNS OF AMINO ACIDS FOR 4XE3_A_CL6A502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a99 PUTRESCINE-BINDING
PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		4 LEU A 299
THR A  53
VAL A  57
ILE A  55
 None
 0.89A 4xe3A-1a99A:
0.0		 4xe3A-1a99A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 184
ALA A 246
VAL A 242
ILE A 170
 None
 0.97A 4xe3A-1cliA:
0.0		 4xe3A-1cliA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e2z CYTOCHROME F

(Chlamydomonas
reinhardtii) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		4 LEU A 113
ALA A  47
VAL A  89
ILE A  93
 None
 0.90A 4xe3A-1e2zA:
0.0		 4xe3A-1e2zA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE

(Streptomyces
antibioticus) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03726
(PNPase) 		4 ALA A 486
THR A 471
VAL A 438
ILE A 435
 None
 0.95A 4xe3A-1e3hA:
0.0		 4xe3A-1e3hA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e59 PHOSPHOGLYCERATE
MUTASE

(Escherichia
coli) 		PF00300
(His_Phos_1) 		4 LEU A 190
ALA A 182
VAL A 178
ILE A 179
 None
 0.89A 4xe3A-1e59A:
0.0		 4xe3A-1e59A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnx BETA-GLUCOSIDASE

(Streptomyces
sp.) 		PF00232
(Glyco_hydro_1) 		4 LEU A 366
ALA A 413
VAL A 424
ILE A 418
 None
 0.86A 4xe3A-1gnxA:
0.0		 4xe3A-1gnxA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		4 LEU A 322
ALA A 289
VAL A 474
ILE A 526
 None
 0.95A 4xe3A-1gz4A:
0.0		 4xe3A-1gz4A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iir GLYCOSYLTRANSFERASE
GTFB

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		4 LEU A  17
ALA A  35
VAL A 109
ILE A  87
 None
 0.89A 4xe3A-1iirA:
0.0		 4xe3A-1iirA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j33 COBT

(Thermus
thermophilus) 		PF02277
(DBI_PRT) 		4 LEU A 230
ALA A  54
THR A  71
ILE A 165
 None
 0.95A 4xe3A-1j33A:
0.0		 4xe3A-1j33A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4j ACYL-HOMOSERINELACTO
NE SYNTHASE ESAI

(Pantoea
stewartii) 		PF00765
(Autoind_synth) 		4 LEU A 176
ALA A 130
VAL A  67
ILE A  55
 None
 0.94A 4xe3A-1k4jA:
undetectable		 4xe3A-1k4jA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		4 LEU A  17
ALA A 407
VAL A  65
ILE A 401
 None
 0.94A 4xe3A-1kcxA:
undetectable		 4xe3A-1kcxA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l3w EP-CADHERIN

(Xenopus laevis) 		PF00028
(Cadherin) 		4 LEU A 513
ALA A 485
VAL A 525
ILE A 509
 None
 0.97A 4xe3A-1l3wA:
undetectable		 4xe3A-1l3wA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE

(Methanothermobacter
thermautotrophicus) 		PF00215
(OMPdecase) 		4 LEU A  21
ALA A  18
VAL A  34
ILE A  38
 None
UP6  A5001 (-3.7A)
None
None
 0.89A 4xe3A-1losA:
undetectable		 4xe3A-1losA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0u GST2 GENE PRODUCT

(Drosophila
melanogaster) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 LEU A  67
ALA A 203
VAL A 138
ILE A 141
 None
 0.73A 4xe3A-1m0uA:
undetectable		 4xe3A-1m0uA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mxs KDPG ALDOLASE

(Pseudomonas
putida) 		PF01081
(Aldolase) 		4 LEU A  66
ALA A  97
VAL A 103
ILE A 121
 None
 0.99A 4xe3A-1mxsA:
undetectable		 4xe3A-1mxsA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzj HYPOTHETICAL PROTEIN
YADB

(Escherichia
coli) 		PF00749
(tRNA-synt_1c) 		4 LEU A  23
ALA A 249
VAL A 267
ILE A 270
 None
 0.90A 4xe3A-1nzjA:
undetectable		 4xe3A-1nzjA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osn THYMIDINE KINASE

(Human
alphaherpesvirus
3) 		PF00693
(Herpes_TK) 		4 LEU A  73
ALA A  82
THR A  86
ILE A  65
 None
None
None
BVP  A 500 ( 4.2A)
 0.86A 4xe3A-1osnA:
undetectable		 4xe3A-1osnA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 APOCYTOCHROME F

(Chlamydomonas
reinhardtii) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		4 LEU A 113
ALA A  47
VAL A  89
ILE A  93
 None
 0.96A 4xe3A-1q90A:
undetectable		 4xe3A-1q90A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
SMALL SUBUNIT

(Pseudomonas
putida) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		4 LEU A  95
ALA A 104
VAL A 133
ILE A 151
 None
 0.99A 4xe3A-1t3qA:
undetectable		 4xe3A-1t3qA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE

(Escherichia
coli) 		PF00291
(PALP)
PF00585
(Thr_dehydrat_C) 		4 LEU A 192
ALA A 292
VAL A 209
ILE A 210
 PLP  A 962 (-4.5A)
None
None
None
 0.95A 4xe3A-1tdjA:
undetectable		 4xe3A-1tdjA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ARP2/3 COMPLEX 16KDA
SUBUNIT
ARP2/3 COMPLEX 20KDA
SUBUNIT

(Bos taurus) 		PF04699
(P16-Arc)
PF05856
(ARPC4) 		4 ALA F  11
THR F  15
VAL G 144
ILE G 141
 None
 0.88A 4xe3A-1u2vF:
undetectable		 4xe3A-1u2vF:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ARP2/3 COMPLEX 16KDA
SUBUNIT
ARP2/3 COMPLEX 20KDA
SUBUNIT

(Bos taurus) 		PF04699
(P16-Arc)
PF05856
(ARPC4) 		4 LEU G 125
ALA F  11
THR F  15
ILE G 141
 None
 0.86A 4xe3A-1u2vG:
undetectable		 4xe3A-1u2vG:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vec ATP-DEPENDENT RNA
HELICASE P54

(Homo sapiens) 		PF00270
(DEAD) 		4 LEU A 140
ALA A 156
VAL A 160
ILE A 159
 None
 0.89A 4xe3A-1vecA:
undetectable		 4xe3A-1vecA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdi RV3303C-LPDA

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A   8
ALA A 314
THR A 307
VAL A 289
ILE A 291
 FAD  A 999 ( 4.8A)
None
None
None
None
 1.10A 4xe3A-1xdiA:
undetectable		 4xe3A-1xdiA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnj BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		no annotation 4 LEU B 291
ALA B 353
VAL B 369
ILE B 366
 None
 0.98A 4xe3A-1xnjB:
undetectable		 4xe3A-1xnjB:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xqp 8-OXOGUANINE DNA
GLYCOSYLASE

(Pyrobaculum
aerophilum) 		PF09171
(AGOG) 		4 ALA A 207
THR A 210
VAL A  10
ILE A  11
 None
 0.96A 4xe3A-1xqpA:
undetectable		 4xe3A-1xqpA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yrv UBIQUITIN-CONJUGATIN
G LIGASE MGC351130

(Homo sapiens) 		PF00179
(UQ_con) 		4 LEU A  93
ALA A 111
VAL A  38
ILE A  40
 None
 0.89A 4xe3A-1yrvA:
undetectable		 4xe3A-1yrvA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbt PEPTIDE CHAIN
RELEASE FACTOR 1

(Streptococcus
mutans) 		PF00472
(RF-1)
PF03462
(PCRF) 		4 LEU A 338
ALA A 141
VAL A 207
ILE A 113
 None
 0.98A 4xe3A-1zbtA:
undetectable		 4xe3A-1zbtA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A

(Homo sapiens) 		PF00233
(PDEase_I) 		4 LEU A 243
ALA A 248
THR A 251
ILE A 201
 None
 0.89A 4xe3A-1zklA:
undetectable		 4xe3A-1zklA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		4 ALA A 239
THR A 242
VAL A 156
ILE A 157
 None
 0.83A 4xe3A-2aazA:
undetectable		 4xe3A-2aazA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aw5 NADP-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		4 LEU A 312
ALA A 279
VAL A 461
ILE A 513
 None
 0.93A 4xe3A-2aw5A:
undetectable		 4xe3A-2aw5A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cf5 CINNAMYL ALCOHOL
DEHYDROGENASE

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 224
THR A 251
VAL A 168
ILE A 249
 None
 0.95A 4xe3A-2cf5A:
undetectable		 4xe3A-2cf5A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg8 DIHYDRONEOPTERIN
ALDOLASE
6-HYDROXYMETHYL-7,8-
DIHYDROPTERIN
SYNTHASE

(Streptococcus
pneumoniae) 		PF01288
(HPPK)
PF02152
(FolB) 		4 LEU A 191
ALA A 140
VAL A 178
ILE A 151
 None
 0.92A 4xe3A-2cg8A:
undetectable		 4xe3A-2cg8A:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dqb DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE,
PUTATIVE

(Thermus
thermophilus) 		PF01966
(HD)
PF13286
(HD_assoc) 		4 LEU A 296
ALA A 258
VAL A  86
ILE A  90
 None
 0.88A 4xe3A-2dqbA:
undetectable		 4xe3A-2dqbA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drw D-AMINO ACID AMIDASE

(Ochrobactrum
anthropi) 		PF00144
(Beta-lactamase) 		4 LEU A 103
ALA A 241
VAL A 131
ILE A 130
 None
 0.94A 4xe3A-2drwA:
undetectable		 4xe3A-2drwA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2euh NADP DEPENDENT NON
PHOSPHORYLATING
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Streptococcus
mutans) 		PF00171
(Aldedh) 		4 ALA A 160
THR A 104
VAL A  71
ILE A 108
 None
 0.95A 4xe3A-2euhA:
undetectable		 4xe3A-2euhA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjr MALATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A  58
ALA A  22
THR A  89
ILE A  87
 None
None
APR  A3001 (-4.9A)
None
 0.98A 4xe3A-2hjrA:
undetectable		 4xe3A-2hjrA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i3o GAMMA-GLUTAMYLTRANSF
ERASE RELATED
PROTEIN

(Thermoplasma
acidophilum) 		PF01019
(G_glu_transpept) 		4 LEU A  30
ALA A  42
VAL A 344
ILE A 346
 None
 0.91A 4xe3A-2i3oA:
undetectable		 4xe3A-2i3oA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ALA A 396
THR A 399
VAL A 302
ILE A 456
 None
 0.79A 4xe3A-2iwzA:
undetectable		 4xe3A-2iwzA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx8 TRNA-SPECIFIC
ADENOSINE DEAMINASE

(Streptococcus
pyogenes) 		PF14437
(MafB19-deam) 		4 LEU A  88
ALA A 101
VAL A 122
ILE A 128
 None
 0.98A 4xe3A-2nx8A:
undetectable		 4xe3A-2nx8A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocd L-ASPARAGINASE I

(Vibrio cholerae) 		PF00710
(Asparaginase) 		4 LEU A 313
ALA A 308
VAL A 269
ILE A 239
 None
 0.98A 4xe3A-2ocdA:
undetectable		 4xe3A-2ocdA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjd RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE C

(Escherichia
coli) 		PF05175
(MTS)
PF08468
(MTS_N) 		4 LEU A 188
ALA A 213
VAL A 200
ILE A 221
 None
 0.89A 4xe3A-2pjdA:
undetectable		 4xe3A-2pjdA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjf BIFUNCTIONAL
3'-PHOSPHOADENOSINE
5'-PHOSPHOSULFATE
SYNTHETASE 1

(Homo sapiens) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		4 LEU A 291
ALA A 353
VAL A 369
ILE A 366
 None
 0.94A 4xe3A-2qjfA:
undetectable		 4xe3A-2qjfA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r87 PURP PROTEIN PF1517

(Pyrococcus
furiosus) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		4 LEU A  38
ALA A  29
THR A   7
ILE A  16
 None
 0.91A 4xe3A-2r87A:
undetectable		 4xe3A-2r87A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115

(Homo sapiens) 		PF04869
(Uso1_p115_head) 		4 ALA A 327
THR A 331
VAL A 385
ILE A 334
 None
 0.76A 4xe3A-2w3cA:
undetectable		 4xe3A-2w3cA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wws COAT PROTEIN

(Physalis mottle
virus) 		PF00983
(Tymo_coat) 		4 LEU A 154
ALA A  50
THR A  48
VAL A  92
 None
 0.97A 4xe3A-2wwsA:
undetectable		 4xe3A-2wwsA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd3 MALTOSE/MALTODEXTRIN
-BINDING PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		4 LEU A 391
ALA A 405
VAL A 383
ILE A 412
 None
 0.99A 4xe3A-2xd3A:
undetectable		 4xe3A-2xd3A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy4 ZINC ABC
TRANSPORTER,
PERIPLASMIC
ZINC-BINDING PROTEIN

(Salmonella
enterica) 		PF01297
(ZnuA) 		4 LEU A 150
ALA A 155
THR A 158
VAL A  81
 None
 0.96A 4xe3A-2xy4A:
undetectable		 4xe3A-2xy4A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z04 PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
ATPASE SUBUNIT

(Aquifex
aeolicus) 		PF02222
(ATP-grasp) 		4 ALA A 277
THR A 279
VAL A   4
ILE A  60
 None
 0.90A 4xe3A-2z04A:
undetectable		 4xe3A-2z04A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a76 GAMMA-HEXACHLOROCYCL
OHEXANE
DEHYDROCHLORINASE

(Sphingomonas
paucimobilis) 		PF13577
(SnoaL_4) 		4 LEU A  59
ALA A 131
THR A 133
ILE A 109
 None
GOL  A 502 (-3.0A)
SPD  A 300 (-4.0A)
None
 0.97A 4xe3A-3a76A:
undetectable		 4xe3A-3a76A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a7s UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE ISOZYME L5

(Homo sapiens) 		PF01088
(Peptidase_C12) 		4 LEU A  55
ALA A  92
VAL A  32
ILE A 223
 None
 0.82A 4xe3A-3a7sA:
undetectable		 4xe3A-3a7sA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b78 EXOTOXIN A

(Pseudomonas
aeruginosa) 		PF09009
(Exotox-A_cataly) 		4 LEU B 508
ALA B 541
THR B 554
ILE B 471
 None
 0.94A 4xe3A-3b78B:
undetectable		 4xe3A-3b78B:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3br8 PROBABLE
ACYLPHOSPHATASE

(Bacillus
subtilis) 		PF00708
(Acylphosphatase) 		4 LEU A  30
ALA A  59
VAL A  74
ILE A  72
 None
 0.95A 4xe3A-3br8A:
undetectable		 4xe3A-3br8A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5

(Schizosaccharomyces
pombe) 		PF04699
(P16-Arc)
PF05856
(ARPC4) 		4 ALA F  11
THR F  15
VAL G 145
ILE G 142
 None
 0.96A 4xe3A-3dwlF:
undetectable		 4xe3A-3dwlF:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 4
ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 5

(Schizosaccharomyces
pombe) 		PF04699
(P16-Arc)
PF05856
(ARPC4) 		4 LEU G 126
ALA F  11
THR F  15
ILE G 142
 None
 0.89A 4xe3A-3dwlG:
undetectable		 4xe3A-3dwlG:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq2 GENERAL VESICULAR
TRANSPORT FACTOR
P115

(Bos taurus) 		PF04869
(Uso1_p115_head) 		4 ALA A 327
THR A 331
VAL A 385
ILE A 334
 None
 0.89A 4xe3A-3gq2A:
undetectable		 4xe3A-3gq2A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0n UNCHARACTERIZED
PROTEIN DUF1470

(Jannaschia sp.
CCS1) 		PF07336
(ABATE)
PF11706
(zf-CGNR) 		4 LEU A 132
ALA A  75
VAL A 155
ILE A 146
 None
 0.88A 4xe3A-3h0nA:
undetectable		 4xe3A-3h0nA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hyk HOLO-[ACYL-CARRIER-P
ROTEIN] SYNTHASE

(Bacillus
anthracis) 		PF01648
(ACPS) 		4 LEU A 114
ALA A  59
VAL A  72
ILE A  68
 None
None
None
CL  A 122 (-4.4A)
 0.98A 4xe3A-3hykA:
undetectable		 4xe3A-3hykA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifr CARBOHYDRATE KINASE,
FGGY

(Rhodospirillum
rubrum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LEU A 424
ALA A 406
VAL A 273
ILE A 255
 None
 0.76A 4xe3A-3ifrA:
undetectable		 4xe3A-3ifrA:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij6 UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Lactobacillus
acidophilus) 		PF04909
(Amidohydro_2) 		4 LEU A  60
ALA A  99
VAL A 114
ILE A 118
 None
 0.93A 4xe3A-3ij6A:
undetectable		 4xe3A-3ij6A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9y 1,25-DIHYDROXYVITAMI
N D(3)
24-HYDROXYLASE,
MITOCHONDRIAL

(Rattus
norvegicus) 		PF00067
(p450) 		4 ALA A 326
THR A 330
VAL A 391
ILE A 500
 HEM  A 520 ( 3.3A)
HEM  A 520 ( 3.8A)
HEM  A 520 ( 4.8A)
None
 0.82A 4xe3A-3k9yA:
26.6		 4xe3A-3k9yA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgs 5'-METHYLTHIOADENOSI
NE NUCLEOSIDASES

(Arabidopsis
thaliana) 		PF01048
(PNP_UDP_1) 		4 ALA A  95
THR A  99
VAL A 217
ILE A 111
 None
 0.88A 4xe3A-3lgsA:
undetectable		 4xe3A-3lgsA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moy PROBABLE ENOYL-COA
HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		4 LEU A 117
ALA A 101
VAL A  38
ILE A  19
 None
 0.95A 4xe3A-3moyA:
undetectable		 4xe3A-3moyA:
24.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nra ASPARTATE
AMINOTRANSFERASE

(Rhodobacter
sphaeroides) 		PF00155
(Aminotran_1_2) 		4 ALA A 119
THR A 121
VAL A 245
ILE A 270
 None
 0.94A 4xe3A-3nraA:
undetectable		 4xe3A-3nraA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oei RELK (TOXIN RV3358)

(Mycobacterium
tuberculosis) 		PF06769
(YoeB_toxin) 		4 LEU C  15
ALA C  25
THR C  29
ILE C  32
 None
 0.71A 4xe3A-3oeiC:
undetectable		 4xe3A-3oeiC:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oid ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH]

(Bacillus
subtilis) 		PF13561
(adh_short_C2) 		4 LEU A 161
ALA A 121
VAL A  63
ILE A  69
 None
None
NDP  A 501 (-3.7A)
None
 0.93A 4xe3A-3oidA:
undetectable		 4xe3A-3oidA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5b LOW DENSITY
LIPOPROTEIN RECEPTOR
VARIANT

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition) 		4 LEU L 590
ALA L 500
THR L 513
ILE L 521
 None
 0.97A 4xe3A-3p5bL:
undetectable		 4xe3A-3p5bL:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8n 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		4 LEU A 438
ALA A 362
VAL A 382
ILE A 370
 None
 0.89A 4xe3A-3q8nA:
undetectable		 4xe3A-3q8nA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Sorangium
cellulosum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A  92
ALA A  69
VAL A  38
ILE A  12
 None
 0.79A 4xe3A-3s5sA:
undetectable		 4xe3A-3s5sA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgg HYPOTHETICAL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF14323
(GxGYxYP_C)
PF16216
(GxGYxYP_N) 		4 LEU A 179
ALA A 174
VAL A 134
ILE A 143
 None
 0.95A 4xe3A-3sggA:
undetectable		 4xe3A-3sggA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfo PUTATIVE
3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		4 LEU A  60
ALA A  74
VAL A 123
ILE A  82
 None
 0.96A 4xe3A-3tfoA:
undetectable		 4xe3A-3tfoA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3two MANNITOL
DEHYDROGENASE

(Helicobacter
pylori) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ALA A 161
THR A 165
VAL A 182
ILE A 239
 None
 0.93A 4xe3A-3twoA:
undetectable		 4xe3A-3twoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waf IRON ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING PROTEIN

(Thermus
thermophilus) 		PF13416
(SBP_bac_8) 		4 LEU A 269
THR A  46
VAL A  50
ILE A  48
 None
 0.85A 4xe3A-3wafA:
undetectable		 4xe3A-3wafA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl1 CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		4 LEU A 172
ALA A 187
VAL A 102
ILE A  58
 None
 0.93A 4xe3A-3wl1A:
undetectable		 4xe3A-3wl1A:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsv L-LACTATE
DEHYDROGENASE

(Enterococcus
mundtii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 LEU A 128
THR A 240
VAL A  16
ILE A  20
 None
 0.89A 4xe3A-3wsvA:
undetectable		 4xe3A-3wsvA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ze7 PERIPLASMIC [NIFESE]
HYDROGENASE, LARGE
SUBUNIT,
SELENOCYSTEINE-CONTA
INING

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		4 LEU B 465
ALA B 485
VAL B  24
ILE B  27
 None
 0.95A 4xe3A-3ze7B:
undetectable		 4xe3A-3ze7B:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx2 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 1

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		4 ALA A  95
THR A  98
VAL A 152
ILE A 101
 None
 0.95A 4xe3A-3zx2A:
undetectable		 4xe3A-3zx2A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bej DYNAMIN 1-LIKE
PROTEIN

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 LEU A  67
ALA A 286
THR A 282
VAL A 258
ILE A 262
 None
 1.11A 4xe3A-4bejA:
undetectable		 4xe3A-4bejA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bps FKBO

(Streptomyces
hygroscopicus) 		no annotation 4 ALA A 112
THR A 115
VAL A 141
ILE A 189
 None
 0.96A 4xe3A-4bpsA:
undetectable		 4xe3A-4bpsA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c60 OCHRATOXINASE

(Aspergillus
niger) 		PF01979
(Amidohydro_1) 		4 LEU A 305
ALA A 249
VAL A 274
ILE A 273
 None
 0.92A 4xe3A-4c60A:
undetectable		 4xe3A-4c60A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emb 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Borreliella
burgdorferi) 		PF00300
(His_Phos_1) 		4 LEU A 194
ALA A 186
VAL A 182
ILE A 183
 None
 0.97A 4xe3A-4embA:
undetectable		 4xe3A-4embA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emy AMINOTRANSFERASE
CLASS I AND II

(Anaerococcus
prevotii) 		PF00155
(Aminotran_1_2) 		4 LEU A 399
ALA A 404
THR A 407
ILE A 366
 None
 0.92A 4xe3A-4emyA:
undetectable		 4xe3A-4emyA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjh PHOSPHOMANNOMUTASE

(Brucella
melitensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ALA A  25
THR A  29
VAL A  50
ILE A  99
 None
 0.94A 4xe3A-4hjhA:
undetectable		 4xe3A-4hjhA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3u ALDEHYDE
DEHYDROGENASE (NAD+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 LEU A  80
ALA A 200
VAL A 168
ILE A 172
 None
 0.95A 4xe3A-4i3uA:
undetectable		 4xe3A-4i3uA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhb MOLYBDOPTERIN
ADENYLYLTRANSFERASE

(Pyrococcus
furiosus) 		PF00994
(MoCF_biosynth) 		4 LEU A  97
THR A  78
VAL A  61
ILE A  19
 None
 0.99A 4xe3A-4lhbA:
undetectable		 4xe3A-4lhbA:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		4 LEU A  79
ALA A 333
VAL A 128
ILE A 339
 None
 0.91A 4xe3A-4lvqA:
undetectable		 4xe3A-4lvqA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvq PHOSPHATE-BINDING
PROTEIN PSTS 3

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		4 LEU A  79
THR A 364
VAL A 128
ILE A 339
 None
 0.95A 4xe3A-4lvqA:
undetectable		 4xe3A-4lvqA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mix PUTATIVE
INSECTICIDAL TOXIN

(Photorhabdus
asymbiotica) 		PF04488
(Gly_transf_sug) 		4 LEU A2328
ALA A2354
VAL A2317
ILE A2294
 None
 0.94A 4xe3A-4mixA:
undetectable		 4xe3A-4mixA:
19.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mm0 P450-LIKE
MONOOXYGENASE

(Streptomyces
griseoviridis) 		PF00067
(p450) 		4 LEU A 121
ALA A 131
VAL A 246
ILE A 392
 None
 0.93A 4xe3A-4mm0A:
44.4		 4xe3A-4mm0A:
42.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7d GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		4 ALA A 338
THR A 342
VAL A 358
ILE A 345
 None
 0.98A 4xe3A-4o7dA:
undetectable		 4xe3A-4o7dA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo3 HYPOTHETICAL PROTEIN

(Parabacteroides
merdae) 		PF01408
(GFO_IDH_MocA)
PF16490
(Oxidoreduct_C) 		4 LEU A 448
ALA A 146
THR A 126
ILE A 129
 None
 0.89A 4xe3A-4oo3A:
undetectable		 4xe3A-4oo3A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqf PROTEIN RECA

(Mycobacterium
tuberculosis) 		PF00154
(RecA) 		4 LEU A  52
ALA A  47
VAL A  76
ILE A 269
 None
 0.94A 4xe3A-4oqfA:
undetectable		 4xe3A-4oqfA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		4 ALA B 363
THR B 339
VAL B 423
ILE B 424
 None
 0.94A 4xe3A-4ov6B:
undetectable		 4xe3A-4ov6B:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8e 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Vibrio cholerae) 		PF00926
(DHBP_synthase) 		4 LEU A  51
ALA A 123
VAL A 138
ILE A 100
 None
 0.96A 4xe3A-4p8eA:
undetectable		 4xe3A-4p8eA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1t GLUTAMATE 5-KINASE

(Burkholderia
thailandensis) 		PF00696
(AA_kinase)
PF01472
(PUA) 		4 LEU A 246
ALA A  37
VAL A 134
ILE A 100
 None
 0.88A 4xe3A-4q1tA:
undetectable		 4xe3A-4q1tA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwt LEIOMODIN-2

(Homo sapiens) 		no annotation 4 LEU C 260
ALA C 255
VAL C 243
ILE C 248
 None
 0.99A 4xe3A-4rwtC:
undetectable		 4xe3A-4rwtC:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6v DI-/TRIPEPTIDE
TRANSPORTER

(Yersinia
enterocolitica) 		PF00854
(PTR2) 		4 LEU A 350
ALA A 345
VAL A 410
ILE A 413
 None
 0.95A 4xe3A-4w6vA:
undetectable		 4xe3A-4w6vA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr3 ALANINE RACEMASE,
BIOSYNTHETIC

(Escherichia
coli) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 LEU A 237
THR A 286
VAL A 301
ILE A 297
 None
 0.84A 4xe3A-4wr3A:
undetectable		 4xe3A-4wr3A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z17 ENOLASE

(Chloroflexus
aurantiacus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 LEU A  95
ALA A 109
VAL A  24
ILE A  22
 None
 0.98A 4xe3A-4z17A:
undetectable		 4xe3A-4z17A:
24.48