SIMILAR PATTERNS OF AMINO ACIDS FOR 4XDT_A_ACTA408

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3l ORN/LYS/ARG
DECARBOXYLASE FAMILY
PROTEIN

(Staphylococcus
aureus) 		PF01276
(OKR_DC_1)
PF03711
(OKR_DC_1_C) 		4 ARG A 397
LEU A 442
LYS A 437
TRP A 384
 None
 1.11A 4xdtA-2x3lA:
0.0		 4xdtA-2x3lA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psh PROTEIN HI_1472

(Haemophilus
influenzae) 		PF01497
(Peripla_BP_2) 		4 ARG A 136
LEU A 150
LYS A 221
ASN A 147
 None
 1.37A 4xdtA-3pshA:
0.0		 4xdtA-3pshA:
23.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xdt FAD:PROTEIN FMN
TRANSFERASE

(Treponema
pallidum) 		PF02424
(ApbE) 		5 ARG A  24
LEU A 185
LYS A 198
TRP A 212
ASN A 213
 ACT  A 408 (-3.1A)
ACT  A 408 (-3.9A)
ACT  A 408 (-2.8A)
ACT  A 408 ( 4.8A)
ACT  A 408 (-4.4A)
 0.22A 4xdtA-4xdtA:
57.2		 4xdtA-4xdtA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yk8 MEIOTICALLY
UP-REGULATED GENE 66
PROTEIN

(Schizosaccharomyces
pombe) 		PF07855
(ATG101) 		4 ARG A  31
LEU A  85
TRP A 103
ASN A   3
 None
 1.30A 4xdtA-4yk8A:
0.0		 4xdtA-4yk8A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I,
MODIFICATION SUBUNIT

(Escherichia
coli) 		PF01555
(N6_N4_Mtase) 		4 LEU A 175
LYS A  63
TRP A  60
ASN A  59
 None
 1.18A 4xdtA-4zcfA:
0.0		 4xdtA-4zcfA:
19.01