SIMILAR PATTERNS OF AMINO ACIDS FOR 4X61_A_SAMA701_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dq3 | ENDONUCLEASE (Pyrococcusfuriosus) |
PF09061(Stirrup)PF09062(Endonuc_subdom)PF14528(LAGLIDADG_3)PF14890(Intein_splicing) | 5 | GLY A 148GLY A 150LEU A 220MET A 263LEU A 246 | None | 1.24A | 4x61A-1dq3A:0.0 | 4x61A-1dq3A:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ehy | PROTEIN (SOLUBLEEPOXIDE HYDROLASE) (Agrobacteriumtumefaciens) |
PF00561(Abhydrolase_1) | 5 | GLY A 243GLY A 245PRO A 135ARG A 288LEU A 277 | None | 1.24A | 4x61A-1ehyA:0.4 | 4x61A-1ehyA:19.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f2j | FRUCTOSE-BISPHOSPHATE ALDOLASE,GLYCOSOMAL (Trypanosomabrucei) |
PF00274(Glycolytic) | 5 | LEU A 186GLY A 235PRO A 275LEU A 274ARG A 182 | None | 1.22A | 4x61A-1f2jA:2.5 | 4x61A-1f2jA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f8v | MATURE CAPSIDPROTEIN BETAMATURE CAPSIDPROTEIN GAMMA (Pariacotovirus;Pariacoto virus) |
PF01829(Peptidase_A6)no annotation | 5 | LEU A 52GLY D 398ASN A 49LEU D 396CYH A 344 | None | 1.22A | 4x61A-1f8vA:0.0 | 4x61A-1f8vA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ia7 | CELLULASE CEL9M ([Clostridium]cellulolyticum) |
PF00759(Glyco_hydro_9) | 5 | GLY A 392GLY A 305LEU A 389ASN A 303LEU A 298 | None | 1.30A | 4x61A-1ia7A:undetectable | 4x61A-1ia7A:20.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1itz | TRANSKETOLASE (Zea mays) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | GLY A 264GLY A 262PRO A 39ASN A 270GLU A 283 | None | 1.29A | 4x61A-1itzA:undetectable | 4x61A-1itzA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l5j | ACONITATE HYDRATASE2 (Escherichiacoli) |
PF00330(Aconitase)PF06434(Aconitase_2_N)PF11791(Aconitase_B_N) | 5 | LEU A 123GLY A 290PRO A 293LEU A 335LEU A 347 | None | 1.27A | 4x61A-1l5jA:2.4 | 4x61A-1l5jA:22.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lfw | PEPV (Lactobacillusdelbrueckii) |
PF01546(Peptidase_M20) | 5 | LEU A 283GLY A 265GLY A 267ASN A 278GLU A 95 | None | 1.16A | 4x61A-1lfwA:undetectable | 4x61A-1lfwA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n2m | PYRUVOYL-DEPENDENTARGININEDECARBOXYLASE (Methanocaldococcusjannaschii) |
PF01862(PvlArgDC) | 5 | GLY A 44GLY A 42LEU A 67ASN A 40LEU A 48 | None | 1.19A | 4x61A-1n2mA:undetectable | 4x61A-1n2mA:13.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q1a | HST2 PROTEIN (Saccharomycescerevisiae) |
PF02146(SIR2) | 5 | LEU A 120GLY A 34GLY A 223LEU A 249CYH A 39 | NoneOAD A1001 (-3.5A)OAD A1001 (-3.5A)OAD A1001 (-4.2A)None | 1.19A | 4x61A-1q1aA:undetectable | 4x61A-1q1aA:18.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sb3 | 4-HYDROXYBENZOYL-COAREDUCTASE ALPHASUBUNIT4-HYDROXYBENZOYL-COAREDUCTASE GAMMASUBUNIT (Thaueraaromatica;Thaueraaromatica) |
PF01315(Ald_Xan_dh_C)PF02738(Ald_Xan_dh_C2)PF00111(Fer2)PF01799(Fer2_2) | 5 | GLY C 43LEU C 59ASN A 690MET A 191ARG C 136 | NoneFES C1908 ( 4.2A)NoneNoneNone | 1.28A | 4x61A-1sb3C:undetectable | 4x61A-1sb3C:12.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sg4 | 3,2-TRANS-ENOYL-COAISOMERASE,MITOCHONDRIAL (Homo sapiens) |
PF00378(ECH_1) | 5 | LEU A 54GLY A 112GLY A 65ASN A 26CYH A 119 | None | 1.22A | 4x61A-1sg4A:undetectable | 4x61A-1sg4A:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sng | COG4826: SERINEPROTEASE INHIBITOR (Thermobifidafusca) |
PF00079(Serpin) | 5 | LEU A 286GLY A 44PRO A 68LEU A 69LEU A 58 | NoneCAF A 41 ( 3.6A)NoneNoneNone | 1.31A | 4x61A-1sngA:undetectable | 4x61A-1sngA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ufx | KIAA1526 PROTEIN (Homo sapiens) |
PF00595(PDZ) | 5 | GLY A 67GLY A 26PRO A 34LEU A 65ASN A 28 | None | 1.08A | 4x61A-1ufxA:undetectable | 4x61A-1ufxA:11.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wr8 | PHOSPHOGLYCOLATEPHOSPHATASE (Pyrococcushorikoshii) |
PF08282(Hydrolase_3) | 5 | PRO A 150ASN A 133ARG A 96GLU A 86LEU A 89 | None | 1.32A | 4x61A-1wr8A:2.9 | 4x61A-1wr8A:16.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xm9 | PLAKOPHILIN 1 (Homo sapiens) |
PF00514(Arm) | 5 | LEU A 375GLY A 330GLU A 366LEU A 367CYH A 409 | None | 1.26A | 4x61A-1xm9A:undetectable | 4x61A-1xm9A:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yw1 | PROTEIN YTNJ (Bacillussubtilis) |
PF00296(Bac_luciferase) | 5 | GLY A 122GLY A 94LEU A 113ASN A 124LEU A 422 | NoneNoneNoneFMN A2606 ( 4.5A)None | 1.31A | 4x61A-1yw1A:undetectable | 4x61A-1yw1A:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zmb | ACETYLXYLAN ESTERASERELATED ENZYME (Clostridiumacetobutylicum) |
PF03629(SASA) | 5 | LEU A 142GLY A 113ASN A 190GLU A 110LEU A 111 | None | 1.21A | 4x61A-1zmbA:2.2 | 4x61A-1zmbA:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dw6 | BLL6730 PROTEIN (Bradyrhizobiumjaponicum) |
PF13378(MR_MLE_C) | 5 | GLY A 336PRO A 316LEU A 306ASN A 145LEU A 136 | None | 1.28A | 4x61A-2dw6A:3.8 | 4x61A-2dw6A:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iu4 | DIHYDROXYACETONEKINASE (Lactococcuslactis) |
PF02733(Dak1) | 5 | LEU A 203GLY A 302GLY A 261LEU A 268GLU A 267 | None | 1.19A | 4x61A-2iu4A:2.1 | 4x61A-2iu4A:19.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jzk | CYANOVIRIN-N HOMOLOG (Tuber borchii) |
PF08881(CVNH) | 5 | LEU A 71GLY A 42GLY A 51LEU A 48CYH A 73 | None | 1.19A | 4x61A-2jzkA:undetectable | 4x61A-2jzkA:10.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nwq | PROBABLE SHORT-CHAINDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00106(adh_short) | 5 | LEU A 46GLY A 15GLY A 9LEU A 137ARG A 20 | NoneNoneSO4 A 254 (-3.1A)NoneNone | 1.29A | 4x61A-2nwqA:3.9 | 4x61A-2nwqA:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p17 | PIRIN-LIKE PROTEIN (Geobacilluskaustophilus) |
PF02678(Pirin)PF05726(Pirin_C) | 5 | GLY A 84GLY A 69PRO A 103LEU A 71ARG A 148 | None | 1.31A | 4x61A-2p17A:undetectable | 4x61A-2p17A:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ppq | HOMOSERINE KINASE (Agrobacteriumfabrum) |
PF01636(APH) | 5 | LEU A 110GLY A 208LEU A 77ASN A 198LEU A 206 | NoneNoneNonePO4 A 401 (-2.8A)None | 1.31A | 4x61A-2ppqA:undetectable | 4x61A-2ppqA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q3z | TRANSGLUTAMINASE 2 (Homo sapiens) |
PF00868(Transglut_N)PF00927(Transglut_C)PF01841(Transglut_core) | 5 | LEU A 534LEU A 544LYS A 540MET A 475LEU A 507 | None | 1.21A | 4x61A-2q3zA:undetectable | 4x61A-2q3zA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r44 | UNCHARACTERIZEDPROTEIN (Cytophagahutchinsonii) |
PF07726(AAA_3) | 5 | LEU A 71PRO A 54LEU A 50ASN A 63LEU A 151 | None | 1.23A | 4x61A-2r44A:undetectable | 4x61A-2r44A:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r79 | PERIPLASMIC BINDINGPROTEIN (Pseudomonasaeruginosa) |
PF01497(Peripla_BP_2) | 5 | LEU A 150GLY A 276PRO A 298ARG A 195LEU A 273 | NoneNoneNoneSO4 A 910 (-3.8A)None | 1.25A | 4x61A-2r79A:undetectable | 4x61A-2r79A:18.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vdv | TRNA(GUANINE-N(7)-)-METHYLTRANSFERASE (Saccharomycescerevisiae) |
PF02390(Methyltransf_4) | 5 | GLY E 212PRO E 281LEU E 280LYS E 177LEU E 241 | None | 1.13A | 4x61A-2vdvE:6.2 | 4x61A-2vdvE:16.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xax | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1SUBUNIT ALPHA (Escherichiacoli) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC)PF03477(ATP-cone) | 5 | GLY A 516PRO A 208LEU A 464ASN A 468LEU A 619 | None | 1.31A | 4x61A-2xaxA:2.4 | 4x61A-2xaxA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yuj | UBIQUITIN FUSIONDEGRADATION 1-LIKE (Homo sapiens) |
PF03152(UFD1) | 5 | LEU A 114GLY A 78GLY A 41PRO A 92LEU A 91 | None | 1.32A | 4x61A-2yujA:undetectable | 4x61A-2yujA:15.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yy9 | ZINC FINGER AND BTBDOMAIN-CONTAININGPROTEIN 48 (Mus musculus) |
PF00651(BTB) | 5 | LEU A 30GLY A 68LEU A 97GLU A 101LEU A 102 | None | 1.23A | 4x61A-2yy9A:undetectable | 4x61A-2yy9A:11.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zme | VACUOLARPROTEIN-SORTING-ASSOCIATED PROTEIN 25 (Homo sapiens) |
PF05871(ESCRT-II) | 5 | LEU C 78LEU C 43ASN C 86MET C 49LEU C 59 | None | 1.28A | 4x61A-2zmeC:undetectable | 4x61A-2zmeC:9.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bb8 | CDP-4-KETO-6-DEOXY-D-GLUCOSE-3-DEHYDRASE (Yersiniapseudotuberculosis) |
PF01041(DegT_DnrJ_EryC1) | 5 | LEU A 196GLY A 299LEU A 48GLU A 304LEU A 303 | None | 1.03A | 4x61A-3bb8A:2.2 | 4x61A-3bb8A:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3beo | UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (Bacillusanthracis) |
PF02350(Epimerase_2) | 5 | LEU A 23GLY A 175GLY A 353PRO A 351GLU A 291 | None | 1.16A | 4x61A-3beoA:3.9 | 4x61A-3beoA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bus | METHYLTRANSFERASE (Lechevalieriaaerocolonigenes) |
PF08241(Methyltransf_11) | 5 | GLY A 69GLY A 71PRO A 75LEU A 136GLU A 137 | SAH A 274 (-3.1A)SAH A 274 (-3.4A)SAH A 274 (-4.3A)SAH A 274 (-4.3A)None | 1.31A | 4x61A-3busA:8.5 | 4x61A-3busA:17.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cnh | HYDROLASE FAMILYPROTEIN (Deinococcusradiodurans) |
PF13419(HAD_2) | 5 | LEU A 49GLY A 18LEU A 15ASN A 108LEU A 113 | NoneNoneNonePO4 A 201 (-4.5A)None | 1.15A | 4x61A-3cnhA:undetectable | 4x61A-3cnhA:15.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dh3 | RIBOSOMAL LARGESUBUNITPSEUDOURIDINESYNTHASE F (Escherichiacoli) |
PF00849(PseudoU_synth_2)PF01479(S4) | 5 | GLY A 104PRO A 102LEU A 116ARG A 207LEU A 113 | G E2603 ( 3.6A)NoneNoneNoneNone | 1.10A | 4x61A-3dh3A:undetectable | 4x61A-3dh3A:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3djl | PROTEIN AIDB (Escherichiacoli) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M) | 5 | LEU A 56GLY A 130PRO A 134ASN A 63ARG A 312 | None | 1.31A | 4x61A-3djlA:undetectable | 4x61A-3djlA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gq9 | PRENECK APPENDAGEPROTEIN (Bacillus virusphi29) |
PF11962(Peptidase_G2)PF12708(Pectate_lyase_3) | 5 | LEU A 428GLY A 452LEU A 479ASN A 455ARG A 390 | None | 1.25A | 4x61A-3gq9A:undetectable | 4x61A-3gq9A:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h4x | PHOSPHATIDYLINOSITOL-SPECIFICPHOSPHOLIPASE C1 (Streptomycesantibioticus) |
PF16670(PI-PLC-C1) | 5 | LEU A 58MET A 111GLU A 60LEU A 61CYH A 107 | None | 1.17A | 4x61A-3h4xA:5.9 | 4x61A-3h4xA:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jd8 | NIEMANN-PICK C1PROTEIN (Homo sapiens) |
PF02460(Patched)PF12349(Sterol-sensing)PF16414(NPC1_N) | 5 | LEU A 469GLY A 539GLY A 535PRO A 532LEU A 472 | None | 1.24A | 4x61A-3jd8A:undetectable | 4x61A-3jd8A:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kqf | ENOYL-COAHYDRATASE/ISOMERASEFAMILY PROTEIN (Bacillusanthracis) |
PF00378(ECH_1) | 5 | LEU A 56GLY A 114GLY A 67ASN A 28CYH A 121 | None | 1.30A | 4x61A-3kqfA:2.6 | 4x61A-3kqfA:17.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lh5 | TIGHT JUNCTIONPROTEIN ZO-1 (Homo sapiens) |
PF00625(Guanylate_kin)PF07653(SH3_2) | 5 | LEU A 583GLY A 555GLY A 552LEU A 549ASN A 578 | None | 0.99A | 4x61A-3lh5A:undetectable | 4x61A-3lh5A:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nsw | EXCRETORY-SECRETORYPROTEIN 2 (Ancylostomaceylanicum) |
no annotation | 5 | LEU A 67GLY A 56PRO A 53ASN A 35LEU A 75 | None | 1.32A | 4x61A-3nswA:undetectable | 4x61A-3nswA:11.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p5m | ENOYL-COAHYDRATASE/ISOMERASE (Mycobacteriumavium) |
PF00378(ECH_1) | 5 | LEU A 52GLY A 103GLY A 62ASN A 24CYH A 110 | None | 1.33A | 4x61A-3p5mA:undetectable | 4x61A-3p5mA:17.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q71 | POLY [ADP-RIBOSE]POLYMERASE 14 (Homo sapiens) |
PF01661(Macro) | 5 | GLY A1133GLY A1135PRO A1045LEU A1046MET A1108 | AR6 A 800 (-3.4A)AR6 A 800 (-3.1A)AR6 A 800 (-3.3A)AR6 A 800 (-3.6A)None | 1.21A | 4x61A-3q71A:2.9 | 4x61A-3q71A:16.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3suc | PRENECK APPENDAGEPROTEIN (Bacillus virusphi29) |
PF11962(Peptidase_G2)PF12708(Pectate_lyase_3) | 5 | LEU A 428GLY A 452LEU A 479ASN A 455ARG A 390 | None | 1.22A | 4x61A-3sucA:undetectable | 4x61A-3sucA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tgl | TRIACYL-GLYCEROLACYLHYDROLASE (Rhizomucormiehei) |
PF01764(Lipase_3) | 5 | LEU A 122GLY A 146GLY A 81ASN A 63CYH A 153 | None | 1.30A | 4x61A-3tglA:2.4 | 4x61A-3tglA:18.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ua4 | PROTEIN ARGININEN-METHYLTRANSFERASE5 (Caenorhabditiselegans) |
PF05185(PRMT5)PF17285(PRMT5_TIM)PF17286(PRMT5_C) | 8 | GLY A 414GLY A 416ASN A 452MET A 478ARG A 479GLU A 499LEU A 500CYH A 513 | None | 0.70A | 4x61A-3ua4A:19.6 | 4x61A-3ua4A:34.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ua4 | PROTEIN ARGININEN-METHYLTRANSFERASE5 (Caenorhabditiselegans) |
PF05185(PRMT5)PF17285(PRMT5_TIM)PF17286(PRMT5_C) | 8 | GLY A 414GLY A 416PRO A 419ASN A 452MET A 478GLU A 499LEU A 500CYH A 513 | None | 0.73A | 4x61A-3ua4A:19.6 | 4x61A-3ua4A:34.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ua4 | PROTEIN ARGININEN-METHYLTRANSFERASE5 (Caenorhabditiselegans) |
PF05185(PRMT5)PF17285(PRMT5_TIM)PF17286(PRMT5_C) | 7 | GLY A 414LYS A 451ASN A 452ARG A 479GLU A 499LEU A 500CYH A 513 | None | 0.86A | 4x61A-3ua4A:19.6 | 4x61A-3ua4A:34.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ua4 | PROTEIN ARGININEN-METHYLTRANSFERASE5 (Caenorhabditiselegans) |
PF05185(PRMT5)PF17285(PRMT5_TIM)PF17286(PRMT5_C) | 7 | GLY A 414PRO A 419LYS A 451ASN A 452GLU A 499LEU A 500CYH A 513 | None | 0.91A | 4x61A-3ua4A:19.6 | 4x61A-3ua4A:34.04 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ua4 | PROTEIN ARGININEN-METHYLTRANSFERASE5 (Caenorhabditiselegans) |
PF05185(PRMT5)PF17285(PRMT5_TIM)PF17286(PRMT5_C) | 5 | GLY A 415LYS A 451ARG A 479GLU A 499CYH A 513 | None | 1.12A | 4x61A-3ua4A:19.6 | 4x61A-3ua4A:34.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3va6 | TWO-COMPONENT SYSTEMSENSOR HISTIDINEKINASE (Bacteroidesthetaiotaomicron) |
PF07494(Reg_prop)PF07495(Y_Y_Y) | 5 | LEU A 70GLY A 106GLY A 110PRO A 129LEU A 144 | None | 1.24A | 4x61A-3va6A:undetectable | 4x61A-3va6A:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vps | NAD-DEPENDENTEPIMERASE/DEHYDRATASE (Streptomyceschartreusis) |
PF01370(Epimerase) | 5 | GLY A 14GLY A 17PRO A 44LEU A 40LEU A 37 | NAD A 401 (-3.2A)NAD A 401 (-3.3A)NoneNoneNone | 1.31A | 4x61A-3vpsA:2.7 | 4x61A-3vpsA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zbf | PROTO-ONCOGENETYROSINE-PROTEINKINASE ROS (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | LEU A2070PRO A1938LEU A1937ASN A2005LEU A2000 | None | 1.29A | 4x61A-3zbfA:undetectable | 4x61A-3zbfA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4af5 | HTH-TYPETRANSCRIPTIONALREPRESSOR ACNRCOMPND 2 (Corynebacteriumglutamicum) |
PF00440(TetR_N) | 5 | LEU A 177ASN A 77MET A 86GLU A 154LEU A 157 | None MG A1187 ( 4.4A)NoneNoneNone | 1.31A | 4x61A-4af5A:undetectable | 4x61A-4af5A:15.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b46 | CELL DIVISIONPROTEIN FTSZ (Haloferaxvolcanii) |
PF00091(Tubulin) | 5 | GLY A 135GLY A 106PRO A 138LEU A 137LEU A 164 | NoneGDP A1368 (-3.6A)GDP A1368 (-4.2A)NoneNone | 1.13A | 4x61A-4b46A:undetectable | 4x61A-4b46A:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c4a | PROTEIN ARGININEN-METHYLTRANSFERASE7 (Mus musculus) |
PF06325(PrmA) | 5 | GLY A 72GLY A 74LEU A 78GLU A 144LEU A 145 | SAH A1689 (-3.0A)SAH A1689 ( 3.7A)SAH A1689 (-4.5A)SAH A1689 (-4.4A)SAH A1689 (-4.4A) | 0.49A | 4x61A-4c4aA:18.1 | 4x61A-4c4aA:23.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dag | FUSION GLYCOPROTEINF0 (Humanmetapneumovirus) |
PF00523(Fusion_gly) | 5 | GLY A 257GLY A 255PRO A 274LEU A 273LEU A 221 | None | 1.17A | 4x61A-4dagA:undetectable | 4x61A-4dagA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4exq | UROPORPHYRINOGENDECARBOXYLASE (Burkholderiathailandensis) |
PF01208(URO-D) | 6 | LEU A 262GLY A 296GLY A 332PRO A 300LEU A 298LEU A 281 | None | 1.34A | 4x61A-4exqA:3.4 | 4x61A-4exqA:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f4o | HAPTOGLOBIN (Sus scrofa) |
PF00089(Trypsin) | 5 | LEU C 108GLY C 224GLY C 226ASN C 228LEU C 237 | None | 1.20A | 4x61A-4f4oC:undetectable | 4x61A-4f4oC:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fkz | UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (Bacillussubtilis) |
PF02350(Epimerase_2) | 5 | LEU A 22GLY A 173GLY A 351PRO A 349GLU A 289 | None | 1.12A | 4x61A-4fkzA:3.8 | 4x61A-4fkzA:20.46 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4g56 | HSL7 PROTEIN (Xenopus laevis) |
PF05185(PRMT5)PF17285(PRMT5_TIM)PF17286(PRMT5_C) | 10 | GLY A 361GLY A 363LEU A 367LYS A 389ASN A 390MET A 416ARG A 417GLU A 431LEU A 432CYH A 445 | SAH A 701 (-3.3A)SAH A 701 ( 4.1A)NoneSAH A 701 (-4.0A)NoneSAH A 701 (-4.3A)SAH A 701 ( 4.7A)SAH A 701 (-3.1A)SAH A 701 (-4.5A)SAH A 701 (-3.4A) | 0.49A | 4x61A-4g56A:40.2 | 4x61A-4g56A:80.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4g56 | HSL7 PROTEIN (Xenopus laevis) |
PF05185(PRMT5)PF17285(PRMT5_TIM)PF17286(PRMT5_C) | 10 | GLY A 361GLY A 363PRO A 366LEU A 367LYS A 389ASN A 390MET A 416GLU A 431LEU A 432CYH A 445 | SAH A 701 (-3.3A)SAH A 701 ( 4.1A)NoneNoneSAH A 701 (-4.0A)NoneSAH A 701 (-4.3A)SAH A 701 (-3.1A)SAH A 701 (-4.5A)SAH A 701 (-3.4A) | 0.56A | 4x61A-4g56A:40.2 | 4x61A-4g56A:80.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4g56 | HSL7 PROTEIN (Xenopus laevis) |
PF05185(PRMT5)PF17285(PRMT5_TIM)PF17286(PRMT5_C) | 9 | LEU A 311GLY A 361GLY A 363LYS A 389ASN A 390MET A 416ARG A 417GLU A 431CYH A 445 | SAH A 701 (-4.1A)SAH A 701 (-3.3A)SAH A 701 ( 4.1A)SAH A 701 (-4.0A)NoneSAH A 701 (-4.3A)SAH A 701 ( 4.7A)SAH A 701 (-3.1A)SAH A 701 (-3.4A) | 0.64A | 4x61A-4g56A:40.2 | 4x61A-4g56A:80.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4g56 | HSL7 PROTEIN (Xenopus laevis) |
PF05185(PRMT5)PF17285(PRMT5_TIM)PF17286(PRMT5_C) | 9 | LEU A 311GLY A 361GLY A 363PRO A 366LYS A 389ASN A 390MET A 416GLU A 431CYH A 445 | SAH A 701 (-4.1A)SAH A 701 (-3.3A)SAH A 701 ( 4.1A)NoneSAH A 701 (-4.0A)NoneSAH A 701 (-4.3A)SAH A 701 (-3.1A)SAH A 701 (-3.4A) | 0.68A | 4x61A-4g56A:40.2 | 4x61A-4g56A:80.82 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4gqb | PROTEIN ARGININEN-METHYLTRANSFERASE5 (Homo sapiens) |
PF05185(PRMT5)PF17285(PRMT5_TIM)PF17286(PRMT5_C) | 12 | LEU A 315GLY A 365GLY A 367PRO A 370LEU A 371LYS A 393ASN A 394MET A 420ARG A 421GLU A 435LEU A 436CYH A 449 | 0XU A 701 (-3.9A)0XU A 701 (-2.9A)0XU A 701 ( 3.7A)0XU A 701 (-4.2A)0XU A 701 (-4.3A)0XU A 701 (-3.9A)None0XU A 701 (-4.4A)0XU A 701 ( 4.9A)0XU A 701 (-4.2A)None0XU A 701 (-3.6A) | 0.52A | 4x61A-4gqbA:50.3 | 4x61A-4gqbA:98.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i66 | UNCHARACTERIZEDPROTEIN HOCH_4089 (Haliangiumochraceum) |
PF13709(DUF4159) | 5 | LEU A 116GLY A 178PRO A 145MET A 176LEU A 185 | None | 1.22A | 4x61A-4i66A:undetectable | 4x61A-4i66A:17.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k0e | HEAVY METAL CATIONTRICOMPONENT EFFLUXPUMP ZNEA(CZCA-LIKE) (Cupriavidusmetallidurans) |
PF00873(ACR_tran) | 5 | LEU A 690GLY A 846GLY A 662LEU A 660LEU A 667 | None | 1.33A | 4x61A-4k0eA:undetectable | 4x61A-4k0eA:22.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lgn | CELLULOSE-BINDING,FAMILY II (Acidothermuscellulolyticus) |
no annotation | 5 | LEU A 449GLY A 724GLY A 708ASN A 726LEU A 436 | NoneNoneNoneNoneGOL A 822 (-4.4A) | 1.12A | 4x61A-4lgnA:undetectable | 4x61A-4lgnA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lwo | ARGININEN-METHYLTRANSFERASE,PUTATIVE (Trypanosomabrucei) |
no annotation | 5 | GLY B 62GLY B 64LEU B 68ARG B 359GLU B 142 | None | 1.01A | 4x61A-4lwoB:17.3 | 4x61A-4lwoB:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mll | BETA-LACTAMASE OXA-1 (Escherichiacoli) |
PF00905(Transpeptidase) | 5 | LEU A 161GLY A 214GLY A 227ASN A 226GLU A 230 | 1S6 A 301 ( 4.3A)1S6 A 301 (-3.3A)NoneNoneNone | 1.30A | 4x61A-4mllA:undetectable | 4x61A-4mllA:16.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r16 | 418AA LONGHYPOTHETICALUDP-N-ACETYL-D-MANNOSAMINURONIC ACIDDEHYDROGENASE (Pyrococcushorikoshii) |
PF00984(UDPG_MGDP_dh)PF03720(UDPG_MGDP_dh_C)PF03721(UDPG_MGDP_dh_N) | 5 | GLY A 7GLY A 9PRO A 14ARG A 99GLU A 117 | None | 1.08A | 4x61A-4r16A:4.1 | 4x61A-4r16A:22.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xg0 | UNCHARACTERIZEDPROTEIN (Bordetellabronchiseptica) |
PF07005(DUF1537)PF17042(DUF1357_C) | 5 | LEU A 93GLY A 216GLY A 219PRO A 223LEU A 224 | None | 1.30A | 4x61A-4xg0A:undetectable | 4x61A-4xg0A:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xru | PNKP1 (Capnocytophagagingivalis) |
PF13671(AAA_33) | 5 | GLY A 186LEU A 184ASN A 308ARG A 297CYH A 304 | MG A 401 ( 4.7A)NoneNoneNoneNone | 1.22A | 4x61A-4xruA:3.2 | 4x61A-4xruA:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yam | BETA-ETHERASE (Sphingobium sp.SYK-6) |
PF13417(GST_N_3) | 5 | LEU A 236GLY A 228GLY A 226MET A 233LEU A 196 | None | 1.27A | 4x61A-4yamA:undetectable | 4x61A-4yamA:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zr8 | UROPORPHYRINOGENDECARBOXYLASE (Acinetobacterbaumannii) |
PF01208(URO-D) | 5 | LEU A 256GLY A 290GLY A 329LEU A 292LEU A 275 | None | 1.20A | 4x61A-4zr8A:10.8 | 4x61A-4zr8A:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d3q | DYNAMIN-1,DYNAMIN-1 (Homo sapiens) |
PF00350(Dynamin_N)PF01031(Dynamin_M) | 5 | LEU A 305PRO A 32LEU A 31ASN A 298LEU A 735 | None | 1.11A | 4x61A-5d3qA:undetectable | 4x61A-5d3qA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dwz | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 (Pseudomonasaeruginosa) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | GLY C 116PRO C 74LEU C 67MET C 107GLU C 64 | None | 1.25A | 4x61A-5dwzC:undetectable | 4x61A-5dwzC:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5enz | UDP-GLCNAC2-EPIMERASE (Staphylococcusaureus) |
PF02350(Epimerase_2) | 5 | LEU A 20GLY A 171GLY A 349PRO A 347GLU A 287 | None | 1.31A | 4x61A-5enzA:undetectable | 4x61A-5enzA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gra | TRNA(CYTIDINE/URIDINE-2'-O-)-METHYLTRANSFERASE TRMJ (Zymomonasmobilis) |
PF00588(SpoU_methylase) | 5 | GLY A 20GLY A 16PRO A 13LEU A 10LEU A 59 | None | 1.30A | 4x61A-5graA:2.0 | 4x61A-5graA:18.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hzr | SNF2-FAMILY ATPDEPENDENT CHROMATINREMODELING FACTORLIKE PROTEIN (Thermothelomycesthermophila) |
PF00176(SNF2_N)PF00271(Helicase_C)PF14619(SnAC) | 5 | LEU A 592GLY A 575PRO A 730LEU A 729LEU A 568 | NoneNoneNoneKH2 A1204 (-4.6A)None | 1.32A | 4x61A-5hzrA:3.8 | 4x61A-5hzrA:21.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ipx | ORF49 PROTEIN (Humangammaherpesvirus8) |
PF04793(Herpes_BBRF1) | 5 | LEU A 87GLY A 101ASN A 100LEU A 121CYH A 211 | None | 1.20A | 4x61A-5ipxA:undetectable | 4x61A-5ipxA:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5je8 | 3-HYDROXYISOBUTYRATEDEHYDROGENASE (Bacillus cereus) |
PF03446(NAD_binding_2)PF14833(NAD_binding_11) | 5 | GLY A 8GLY A 10PRO A 15ASN A 33LEU A 65 | NAD A 401 ( 3.7A)NAD A 401 (-3.3A)NoneNoneNAD A 401 (-4.9A) | 1.29A | 4x61A-5je8A:2.8 | 4x61A-5je8A:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jij | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE (Mycolicibacteriumthermoresistibile) |
PF00982(Glyco_transf_20) | 5 | LEU A 47GLY A 164PRO A 151LEU A 154ARG A 51 | None | 1.27A | 4x61A-5jijA:3.7 | 4x61A-5jijA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5khl | HEMIN ABCTRANSPORTER,PERIPLASMICHEMIN-BINDINGPROTEIN HUTB (Vibrio cholerae) |
PF01497(Peripla_BP_2) | 5 | GLY B 186GLY B 183LEU B 147ASN B 189LEU B 275 | None | 1.21A | 4x61A-5khlB:3.5 | 4x61A-5khlB:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5li8 | PUTATIVE CYTOCHROMEP450 126 (Mycobacteriumtuberculosis) |
PF00067(p450) | 5 | GLY A 385GLY A 413PRO A 139LEU A 411LEU A 381 | None | 1.12A | 4x61A-5li8A:undetectable | 4x61A-5li8A:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lq3 | CMEB (Campylobacterjejuni) |
PF00873(ACR_tran) | 5 | LEU A 646PRO A 577LEU A 576MET A 625GLU A 588 | None | 1.29A | 4x61A-5lq3A:undetectable | 4x61A-5lq3A:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m1t | MUCRPHOSPHODIESTERASE (Pseudomonasaeruginosa) |
PF00563(EAL) | 5 | LEU A 605GLY A 586GLY A 584PRO A 554LEU A 557 | None | 1.31A | 4x61A-5m1tA:5.1 | 4x61A-5m1tA:17.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ubk | ACYL-HOMOSERINELACTONE ACYLASE PVDQ (Pseudomonasaeruginosa) |
PF01804(Penicil_amidase) | 5 | LEU A 695GLY A 702PRO A 130LEU A 708ASN A 152 | 83M A 801 ( 4.4A)NoneNoneNoneNone | 1.21A | 4x61A-5ubkA:undetectable | 4x61A-5ubkA:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v2i | GLYCOSYLASPARAGINASE (Elizabethkingiameningoseptica) |
PF01112(Asparaginase_2) | 5 | GLY A 52GLY A 54LYS A 86ARG A 40GLU A 48 | None | 1.19A | 4x61A-5v2iA:undetectable | 4x61A-5v2iA:18.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vkt | CINNAMYL ALCOHOLDEHYDROGENASES(SBCAD4) (Sorghum bicolor) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 92GLY A 73LEU A 141LEU A 164CYH A 308 | NoneNoneNoneNoneGOL A 403 (-3.0A) | 1.28A | 4x61A-5vktA:7.2 | 4x61A-5vktA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wb0 | FUSION GLYCOPROTEINF0 (Humanmetapneumovirus) |
no annotation | 5 | GLY F 257GLY F 255PRO F 274LEU F 273LEU F 221 | None | 1.29A | 4x61A-5wb0F:undetectable | 4x61A-5wb0F:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wrt | SOLUBLE INORGANICPYROPHOSPHATASE (Toxoplasmagondii) |
no annotation | 5 | GLY A 236PRO A 238MET A 122GLU A 202LEU A 204 | None | 1.28A | 4x61A-5wrtA:undetectable | 4x61A-5wrtA:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xau | LAMININ SUBUNITALPHA-5 (Homo sapiens) |
PF02210(Laminin_G_2)PF06009(Laminin_II) | 5 | LEU A3077GLY A3067GLY A2950LEU A2946CYH A2990 | None | 1.28A | 4x61A-5xauA:undetectable | 4x61A-5xauA:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y3r | DNA-DEPENDENTPROTEIN KINASECATALYTIC SUBUNIT (Homo sapiens) |
PF00454(PI3_PI4_kinase)PF02259(FAT)PF02260(FATC)PF08163(NUC194) | 5 | LEU C2219GLY C2181GLY C2179LEU C2083LEU C2171 | None | 1.19A | 4x61A-5y3rC:undetectable | 4x61A-5y3rC:10.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c6k | INTERFERON-INDUCEDPROTEIN WITHTETRATRICOPEPTIDEREPEATS 1 (Homo sapiens) |
no annotation | 5 | LEU A 42ASN A 58GLU A 38LEU A 37CYH A 154 | None | 1.26A | 4x61A-6c6kA:undetectable | 4x61A-6c6kA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dey | - (-) |
no annotation | 5 | GLY A 52GLY A 54LYS A 86ARG A 40GLU A 48 | None | 1.31A | 4x61A-6deyA:undetectable | 4x61A-6deyA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6g72 | NADH-UBIQUINONEOXIDOREDUCTASE CHAIN1NADH DEHYDROGENASE[UBIQUINONE]IRON-SULFUR PROTEIN8, MITOCHONDRIALNADH DEHYDROGENASE[UBIQUINONE] 1 ALPHASUBCOMPLEX SUBUNIT13 (Mus musculus;Mus musculus;Mus musculus) |
no annotationno annotationno annotation | 5 | LEU Z 29GLY Z 38GLY Z 40LEU H 176MET I 28 | None | 1.16A | 4x61A-6g72Z:undetectable | 4x61A-6g72Z:undetectable |