SIMILAR PATTERNS OF AMINO ACIDS FOR 4X5I_A_FOLA201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9x M32 CARBOXYPEPTIDASE

(Pyrococcus
furiosus) 		PF02074
(Peptidase_M32) 		3 ASP A 348
ARG A 303
ARG A 311
 None
 0.89A 4x5iA-1k9xA:
0.0		 4x5iA-1k9xA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgy TRIACYLGLYCEROL
LIPASE

(Rhizopus niveus) 		PF01764
(Lipase_3) 		3 ASP A 243
ARG A 179
ARG A 198
 None
 0.87A 4x5iA-1lgyA:
0.0		 4x5iA-1lgyA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE

(Saccharomyces
cerevisiae) 		PF01259
(SAICAR_synt) 		3 ASP A 171
ARG A 242
ARG A 122
 None
SO4  A 308 (-2.6A)
SO4  A 308 (-2.9A)
 0.96A 4x5iA-1obgA:
0.0		 4x5iA-1obgA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		3 ASP A 209
ARG A 434
ARG A 308
 SAM  A 501 (-3.7A)
None
None
 0.98A 4x5iA-1oltA:
0.0		 4x5iA-1oltA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhf PROTEIN
(PHOSPHOGLYCERATE
MUTASE)

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		3 ASP A 197
ARG A  87
ARG A 186
 None
 0.97A 4x5iA-1qhfA:
1.5		 4x5iA-1qhfA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tez DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Synechococcus
elongatus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 ASP A 101
ARG A 255
ARG A  14
 HDF  A5486 (-3.5A)
None
None
 0.87A 4x5iA-1tezA:
0.2		 4x5iA-1tezA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0f ENDO-ALPHA-SIALIDASE

(Enterobacteria
phage K1F) 		PF12217
(End_beta_propel)
PF12218
(End_N_terminal)
PF12219
(End_tail_spike) 		3 ASP A 731
ARG A 349
ARG A 354
 ASP  A 731 ( 0.6A)
ARG  A 349 ( 0.6A)
ARG  A 354 ( 0.6A)
 0.96A 4x5iA-1v0fA:
0.0		 4x5iA-1v0fA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgq FORMYL-COENZYME A
TRANSFERASE

(Oxalobacter
formigenes) 		PF02515
(CoA_transf_3) 		3 ASP A  12
ARG A 376
ARG A  46
 None
 0.98A 4x5iA-1vgqA:
0.0		 4x5iA-1vgqA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyh PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
BETA SUBUNIT
PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT

(Homo sapiens;
Mus musculus) 		PF13472
(Lipase_GDSL_2)
PF00400
(WD40) 		3 ASP A  41
ARG C 212
ARG C 238
 None
 0.73A 4x5iA-1vyhA:
0.1		 4x5iA-1vyhA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wru 43 KDA TAIL PROTEIN

(Escherichia
virus Mu) 		PF05954
(Phage_GPD) 		3 ASP A 131
ARG A 268
ARG A 336
 None
 0.95A 4x5iA-1wruA:
undetectable		 4x5iA-1wruA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Agrobacterium
tumefaciens) 		PF04095
(NAPRTase) 		3 ASP A  33
ARG A  16
ARG A 161
 None
 0.77A 4x5iA-1ybeA:
undetectable		 4x5iA-1ybeA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yll CONSERVED
HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF05962
(HutD) 		3 ASP A  46
ARG A  61
ARG A  41
 None
 0.90A 4x5iA-1yllA:
undetectable		 4x5iA-1yllA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 ASP B  33
ARG B 359
ARG B 353
 None
 0.78A 4x5iA-2amcB:
undetectable		 4x5iA-2amcB:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 ASP B 157
ARG B 359
ARG B 353
 None
 0.97A 4x5iA-2amcB:
undetectable		 4x5iA-2amcB:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlq GLI-KRUPPEL FAMILY
MEMBER HKR3

(Mus musculus) 		PF00096
(zf-C2H2)
PF13894
(zf-C2H2_4) 		3 ASP A 109
ARG A  28
ARG A  79
 None
 0.86A 4x5iA-2dlqA:
undetectable		 4x5iA-2dlqA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0i 432AA LONG
HYPOTHETICAL
DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Sulfurisphaera
tokodaii) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 ASP A  98
ARG A 228
ARG A  12
 FAD  A1200 (-3.8A)
None
None
 0.93A 4x5iA-2e0iA:
undetectable		 4x5iA-2e0iA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		3 ASP A 293
ARG A  76
ARG A  72
 None
 0.91A 4x5iA-2gfiA:
undetectable		 4x5iA-2gfiA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN

(Thermotoga
maritima) 		PF13177
(DNA_pol3_delta2) 		3 ASP A 278
ARG A 127
ARG A 171
 None
 0.99A 4x5iA-2gnoA:
undetectable		 4x5iA-2gnoA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		3 ASP A 905
ARG A 336
ARG A 341
 None
 0.96A 4x5iA-2ipcA:
undetectable		 4x5iA-2ipcA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7j PUTATIVE SENSORY
BOX/GGDEF FAMILY
PROTEIN

(Vibrio
parahaemolyticus) 		PF02743
(dCache_1) 		3 ASP A 172
ARG A 115
ARG A  82
 None
SO4  A 501 (-2.6A)
SO4  A 501 (-3.2A)
 0.97A 4x5iA-2p7jA:
undetectable		 4x5iA-2p7jA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfq 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		3 ASP A  48
ARG A 344
ARG A 124
 None
FMT  A 601 (-2.6A)
FMT  A 602 (-3.1A)
 0.86A 4x5iA-2qfqA:
undetectable		 4x5iA-2qfqA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbz CYTOCHROME P450-SU1

(Streptomyces
griseolus) 		PF00067
(p450) 		3 ASP A 292
ARG A  73
ARG A 297
 None
VDX  A 501 ( 4.2A)
HEM  A 413 (-3.0A)
 0.98A 4x5iA-2zbzA:
undetectable		 4x5iA-2zbzA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqw PUTATIVE CAPSID
PROTEIN OF PROPHAGE

(Escherichia
coli) 		PF03864
(Phage_cap_E) 		3 ASP A 106
ARG A 126
ARG A  19
 None
 0.86A 4x5iA-3bqwA:
undetectable		 4x5iA-3bqwA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8r THIOREDOXIN
REDUCTASE (TRXB-3)

(Sulfolobus
solfataricus) 		PF07992
(Pyr_redox_2) 		3 ASP A 264
ARG A 126
ARG A 296
 None
NAP  A4001 (-3.0A)
NAP  A4001 (-3.2A)
 0.99A 4x5iA-3f8rA:
undetectable		 4x5iA-3f8rA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4o NITROREDUCTASE
FAMILY PROTEIN

(Clostridioides
difficile) 		PF00881
(Nitroreductase) 		3 ASP A 101
ARG A 155
ARG A 160
 None
FMN  A 300 (-3.9A)
FMN  A 300 (-3.0A)
 0.85A 4x5iA-3h4oA:
undetectable		 4x5iA-3h4oA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA

(Moorella
thermoacetica) 		PF03598
(CdhC) 		3 ASP M 203
ARG M 649
ARG M 616
 None
 0.94A 4x5iA-3i04M:
undetectable		 4x5iA-3i04M:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldr FRUCTOSYLTRANSFERASE

(Aspergillus
japonicus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 ASP A 363
ARG A 616
ARG A 552
 None
 0.87A 4x5iA-3ldrA:
undetectable		 4x5iA-3ldrA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		3 ASP A 160
ARG A 105
ARG A  41
 None
FAD  A 501 (-2.6A)
FAD  A 501 (-3.2A)
 0.98A 4x5iA-3nixA:
undetectable		 4x5iA-3nixA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvs 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Vibrio cholerae) 		PF00275
(EPSP_synthase) 		3 ASP A  48
ARG A 345
ARG A 124
 None
GPJ  A 429 (-2.6A)
GPJ  A 429 (-3.0A)
 0.93A 4x5iA-3nvsA:
undetectable		 4x5iA-3nvsA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ny2 E3 UBIQUITIN-PROTEIN
LIGASE UBR2

(Homo sapiens) 		PF02207
(zf-UBR) 		3 ASP A 118
ARG A 137
ARG A 139
 None
 0.98A 4x5iA-3ny2A:
undetectable		 4x5iA-3ny2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogk CORONATINE-INSENSITI
VE PROTEIN 1
JAZ1 INCOMPLETE
DEGRON PEPTIDE

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		no annotation
PF09425
(CCT_2) 		3 ASP B 407
ARG B 121
ARG Q 206
 None
PO4  B1103 (-3.0A)
PO4  B1102 (-3.1A)
 0.78A 4x5iA-3ogkB:
undetectable		 4x5iA-3ogkB:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pst PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF08324
(PUL)
PF09070
(PFU) 		3 ASP A 392
ARG A 706
ARG A 669
 None
 0.86A 4x5iA-3pstA:
undetectable		 4x5iA-3pstA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r08 MOUSE ANTI-MOUSE
CD3EPSILON ANTIBODY
2C11 HEAVY CHAIN
MOUSE ANTI-MOUSE
CD3EPSILON ANTIBODY
2C11 LIGHT CHAIN

(Cricetulus
migratorius;
Cricetulus
migratorius) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		3 ASP L   1
ARG H  66
ARG H  38
 None
 0.82A 4x5iA-3r08L:
undetectable		 4x5iA-3r08L:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv6 ISOCHORISMATE
SYNTHASE/ISOCHORISMA
TE-PYRUVATE LYASE
MBTI

(Mycobacterium
tuberculosis) 		PF00425
(Chorismate_bind) 		3 ASP A 395
ARG A 149
ARG A 140
 None
 0.96A 4x5iA-3rv6A:
undetectable		 4x5iA-3rv6A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr1 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Coxiella
burnetii) 		PF00275
(EPSP_synthase) 		3 ASP A 233
ARG A 123
ARG A 346
 None
PO4  A 440 (-2.9A)
PO4  A 439 (-2.6A)
 0.97A 4x5iA-3tr1A:
undetectable		 4x5iA-3tr1A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u24 PUTATIVE LIPOPROTEIN

(Shewanella
oneidensis) 		PF05960
(DUF885) 		3 ASP A 289
ARG A 466
ARG A 548
 ZN  A   5 (-2.2A)
None
None
 0.93A 4x5iA-3u24A:
undetectable		 4x5iA-3u24A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3urg ALR1010 PROTEIN

(Nostoc sp. PCC
7120) 		PF11535
(Calci_bind_CcbP) 		3 ASP A 106
ARG A  10
ARG A  13
 None
 0.86A 4x5iA-3urgA:
undetectable		 4x5iA-3urgA:
25.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vay HAD-SUPERFAMILY
HYDROLASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13419
(HAD_2) 		3 ASP A  10
ARG A  50
ARG A  68
 None
IOD  A 305 (-3.4A)
IOD  A 305 ( 4.1A)
 0.98A 4x5iA-3vayA:
undetectable		 4x5iA-3vayA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vte TETRAHYDROCANNABINOL
IC ACID SYNTHASE

(Cannabis sativa) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 ASP A  57
ARG A 110
ARG A 133
 None
 0.79A 4x5iA-3vteA:
undetectable		 4x5iA-3vteA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzh PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
pyogenes) 		PF09704
(Cas_Cas5d) 		3 ASP A 113
ARG A 125
ARG A 132
 None
 0.88A 4x5iA-3vzhA:
undetectable		 4x5iA-3vzhA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1g DNA LIGASE 4

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		3 ASP A 210
ARG A  40
ARG A  47
 None
 0.95A 4x5iA-3w1gA:
undetectable		 4x5iA-3w1gA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag4 EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		3 ASP A 212
ARG A 128
ARG A 124
 None
 0.98A 4x5iA-4ag4A:
undetectable		 4x5iA-4ag4A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b61 ALGINATE PRODUCTION
PROTEIN ALGE

(Pseudomonas
aeruginosa) 		PF13372
(Alginate_exp) 		3 ASP A  72
ARG A 371
ARG A 461
 None
 0.85A 4x5iA-4b61A:
undetectable		 4x5iA-4b61A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d65 PORIN 2

(Providencia
stuartii) 		PF00267
(Porin_1) 		3 ASP A  34
ARG A 126
ARG A  38
 None
 0.89A 4x5iA-4d65A:
undetectable		 4x5iA-4d65A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		3 ASP A  99
ARG A 360
ARG A  51
 None
IPE  A 405 ( 4.7A)
IPE  A 405 (-2.5A)
 0.87A 4x5iA-4e1eA:
undetectable		 4x5iA-4e1eA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ASP A 388
ARG A 364
ARG A 362
 None
 0.70A 4x5iA-4f7kA:
undetectable		 4x5iA-4f7kA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ft6 PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		3 ASP A 167
ARG A 378
ARG A  20
 None
 0.97A 4x5iA-4ft6A:
undetectable		 4x5iA-4ft6A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 ASP A 406
ARG A 935
ARG A 576
 None
 0.90A 4x5iA-4fysA:
undetectable		 4x5iA-4fysA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfi MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 296
ARG A  22
ARG A  25
 ALA  A 402 (-2.5A)
None
GLU  A 403 (-3.5A)
 0.87A 4x5iA-4gfiA:
undetectable		 4x5iA-4gfiA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htp DNA LIGASE 4

(Homo sapiens) 		PF04675
(DNA_ligase_A_N) 		3 ASP A 210
ARG A  40
ARG A  47
 None
 0.93A 4x5iA-4htpA:
undetectable		 4x5iA-4htpA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENC2

(Yersinia
entomophaga) 		no annotation 3 ASP B 114
ARG B 447
ARG B 444
 None
 0.59A 4x5iA-4iglB:
undetectable		 4x5iA-4iglB:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB
YENC2

(Yersinia
entomophaga;
Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN)
no annotation 		3 ASP A1480
ARG B 310
ARG B 683
 K  A1505 (-2.7A)
None
None
 0.94A 4x5iA-4iglA:
undetectable		 4x5iA-4iglA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4itu SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Xanthobacter
autotrophicus) 		PF13561
(adh_short_C2) 		3 ASP A 225
ARG A   4
ARG A  29
 None
 0.91A 4x5iA-4ituA:
undetectable		 4x5iA-4ituA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxr PPE41
ESPG5

(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		PF00823
(PPE)
PF14011
(ESX-1_EspG) 		3 ASP B 121
ARG C  34
ARG B 113
 None
 0.98A 4x5iA-4kxrB:
undetectable		 4x5iA-4kxrB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mij TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		3 ASP A  37
ARG A 174
ARG A 154
 None
GTR  A 405 (-3.0A)
ADA  A 406 ( 3.0A)
 0.96A 4x5iA-4mijA:
undetectable		 4x5iA-4mijA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mm1 GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE

(Methanothermobacter
thermautotrophicus) 		PF01884
(PcrB) 		3 ASP A  57
ARG A  88
ARG A  66
 None
 0.95A 4x5iA-4mm1A:
undetectable		 4x5iA-4mm1A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mp3 PUTATIVE ORNITHINE
CYCLODEAMINASE

(Staphylococcus
aureus) 		PF02423
(OCD_Mu_crystall) 		3 ASP A 239
ARG A  60
ARG A  94
 None
None
GOL  A 402 (-4.0A)
 0.98A 4x5iA-4mp3A:
0.9		 4x5iA-4mp3A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtk VGRG1

(Pseudomonas
aeruginosa) 		PF05954
(Phage_GPD) 		3 ASP A 345
ARG A 246
ARG A 217
 None
 0.94A 4x5iA-4mtkA:
undetectable		 4x5iA-4mtkA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n17 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Burkholderia
ambifaria) 		PF03480
(DctP) 		3 ASP A  33
ARG A 169
ARG A 149
 None
GTR  A 401 (-3.0A)
GTR  A 401 (-3.1A)
 0.96A 4x5iA-4n17A:
undetectable		 4x5iA-4n17A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)

(Bradyrhizobium
sp. BTAi1) 		PF03480
(DctP) 		3 ASP A  29
ARG A 166
ARG A 145
 None
ADA  A 401 (-3.0A)
GTR  A 402 (-3.0A)
 0.98A 4x5iA-4n8yA:
undetectable		 4x5iA-4n8yA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1
SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101

(Arabidopsis
thaliana;
Arabidopsis
thaliana) 		PF01764
(Lipase_3)
PF01764
(Lipase_3) 		3 ASP B 299
ARG A 425
ARG A 493
 None
 0.85A 4x5iA-4nfuB:
undetectable		 4x5iA-4nfuB:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		3 ASP A 187
ARG A 404
ARG A 136
 None
 0.92A 4x5iA-4nmeA:
undetectable		 4x5iA-4nmeA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7z PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Pyrococcus
horikoshii) 		PF01259
(SAICAR_synt) 		3 ASP A 128
ARG A 198
ARG A  93
 None
5GP  A 301 (-3.0A)
5GP  A 301 (-2.9A)
 0.98A 4x5iA-4o7zA:
undetectable		 4x5iA-4o7zA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovr TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Xanthobacter
autotrophicus) 		PF03480
(DctP) 		3 ASP A  32
ARG A 168
ARG A 148
 None
GTR  A 403 (-2.9A)
GTR  A 403 (-3.1A)
 0.97A 4x5iA-4ovrA:
undetectable		 4x5iA-4ovrA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE

(Gallus gallus;
Rattus
norvegicus;
Lobophyllia
hemprichii) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		3 ASP A 346
ARG A 306
ARG A 331
 None
CR8  A 303 ( 2.9A)
CR8  A 303 ( 3.0A)
 0.95A 4x5iA-4oy4A:
undetectable		 4x5iA-4oy4A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		3 ASP A 104
ARG A 351
ARG A  60
 None
1WO  A 402 ( 4.6A)
1WO  A 402 (-2.6A)
 0.88A 4x5iA-4p0vA:
undetectable		 4x5iA-4p0vA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p47 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Ochrobactrum
anthropi) 		PF03480
(DctP) 		3 ASP A  76
ARG A 173
ARG A 152
 None
 0.98A 4x5iA-4p47A:
undetectable		 4x5iA-4p47A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twe N-ACETYLATED-ALPHA-L
INKED ACIDIC
DIPEPTIDASE-LIKE
PROTEIN

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		3 ASP A 224
ARG A 168
ARG A 539
 None
 0.88A 4x5iA-4tweA:
undetectable		 4x5iA-4tweA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgx MOLINATE HYDROLASE

(Gulosibacter
molinativorax) 		PF01979
(Amidohydro_1) 		3 ASP A 312
ARG A  78
ARG A 156
 None
None
MPD  A 501 ( 4.2A)
 0.94A 4x5iA-4wgxA:
undetectable		 4x5iA-4wgxA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjm RIBOKINASE:CARBOHYDR
ATE KINASE, PFKB

(Brucella
abortus) 		PF00294
(PfkB) 		3 ASP A  11
ARG A  67
ARG A  41
 None
 0.95A 4x5iA-4wjmA:
undetectable		 4x5iA-4wjmA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zsl MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		3 ASP A  53
ARG A 392
ARG A 122
 None
 0.61A 4x5iA-4zslA:
undetectable		 4x5iA-4zslA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6f GATING RING OF
POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a) 		3 ASP C 871
ARG C 923
ARG C 934
 None
 0.87A 4x5iA-5a6fC:
0.7		 4x5iA-5a6fC:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aga DNA POLYMERASE THETA

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ASP A 216
ARG A 433
ARG A 480
 MG  A1895 (-3.2A)
None
None
 0.83A 4x5iA-5agaA:
undetectable		 4x5iA-5agaA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d79 BERBERINE BRIDGE
ENZYME-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 ASP A  54
ARG A 107
ARG A 131
 None
 0.88A 4x5iA-5d79A:
undetectable		 4x5iA-5d79A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl7 PORIN

(Acinetobacter
baumannii) 		PF03573
(OprD) 		3 ASP A 168
ARG A 395
ARG A  19
 None
 0.84A 4x5iA-5dl7A:
undetectable		 4x5iA-5dl7A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmu NHEJ POLYMERASE

(Methanocella
paludicola) 		no annotation 3 ASP A 298
ARG A 140
ARG A 149
 None
 0.87A 4x5iA-5dmuA:
undetectable		 4x5iA-5dmuA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT

(Aquifex
aeolicus) 		PF02091
(tRNA-synt_2e) 		3 ASP A 113
ARG A  70
ARG A 163
 None
None
G5A  A 300 (-4.0A)
 0.61A 4x5iA-5f5wA:
undetectable		 4x5iA-5f5wA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE

(Streptococcus
porcinus) 		PF01791
(DeoC) 		3 ASP A 172
ARG A 277
ARG A  33
 None
SO4  A 401 (-3.6A)
SO4  A 403 (-2.5A)
 0.86A 4x5iA-5hjlA:
undetectable		 4x5iA-5hjlA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqb ALPHA-GLUCOSIDASE

(Pseudoalteromonas
sp. K8) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		3 ASP A 460
ARG A 591
ARG A  92
 None
 0.88A 4x5iA-5hqbA:
undetectable		 4x5iA-5hqbA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		3 ASP A 167
ARG A 823
ARG A 799
 None
 0.89A 4x5iA-5jouA:
undetectable		 4x5iA-5jouA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktk POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		3 ASP A 328
ARG A 228
ARG A 252
 None
NDP  A 601 (-3.3A)
NDP  A 601 (-3.7A)
 0.89A 4x5iA-5ktkA:
undetectable		 4x5iA-5ktkA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT
ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT

(Aromatoleum
aromaticum;
Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B)
PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		3 ASP B 334
ARG A 445
ARG B 121
 None
 0.90A 4x5iA-5l9wB:
undetectable		 4x5iA-5l9wB:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT
ACETOPHENONE
CARBOXYLASE ALPHA
SUBUNIT

(Aromatoleum
aromaticum;
Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N)
PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		3 ASP b 498
ARG B 192
ARG B 162
 None
 0.96A 4x5iA-5l9wb:
undetectable		 4x5iA-5l9wb:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA
OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMC

(Escherichia
coli;
Escherichia
coli) 		PF01103
(Bac_surface_Ag)
PF07244
(POTRA)
PF06804
(Lipoprotein_18) 		3 ASP C  64
ARG A 350
ARG A 353
 None
 0.96A 4x5iA-5ljoC:
undetectable		 4x5iA-5ljoC:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqm GLYCOSYL HYDROLASES
FAMILY 2, SUGAR
BINDING DOMAIN

(Bacteroides
thetaiotaomicron) 		PF17132
(Glyco_hydro_106) 		3 ASP A 758
ARG A 875
ARG A 775
 None
 0.76A 4x5iA-5mqmA:
undetectable		 4x5iA-5mqmA:
9.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msx PUTATIVE
ENDO-1,4-BETA-XYLANA
SE

(Bacteroides
thetaiotaomicron) 		PF00754
(F5_F8_type_C)
PF04616
(Glyco_hydro_43) 		3 ASP A 310
ARG A 282
ARG A 350
 None
 0.87A 4x5iA-5msxA:
undetectable		 4x5iA-5msxA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxn PORIN 1

(Providencia
stuartii) 		no annotation 3 ASP A  37
ARG A 129
ARG A  41
 None
 0.94A 4x5iA-5nxnA:
undetectable		 4x5iA-5nxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE

(Methanocaldococcus
jannaschii) 		no annotation 3 ASP A 313
ARG A  59
ARG A 282
 None
 0.90A 4x5iA-5od2A:
undetectable		 4x5iA-5od2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odj SINGLE-STRANDED
DNA-BINDING PROTEIN

(Enterobacter
phage Enc34) 		no annotation 3 ASP A  96
ARG A 112
ARG A 159
 None
 0.86A 4x5iA-5odjA:
undetectable		 4x5iA-5odjA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5onu OUTER MEMBRANE
PROTEIN OMPU

(Vibrio cholerae) 		no annotation 3 ASP A 143
ARG A  74
ARG A 116
 None
GOL  A 402 (-3.0A)
GOL  A 403 (-3.3A)
 0.94A 4x5iA-5onuA:
undetectable		 4x5iA-5onuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u03 CTP SYNTHASE 1

(Homo sapiens) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		3 ASP A 134
ARG A 477
ARG A 532
 None
 0.95A 4x5iA-5u03A:
undetectable		 4x5iA-5u03A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1

(Arabidopsis
thaliana) 		no annotation 3 ASP A 576
ARG A 958
ARG A 718
 None
 0.93A 4x5iA-5wblA:
undetectable		 4x5iA-5wblA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbi PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		no annotation 3 ASP A 165
ARG A 123
ARG A 252
 None
 0.87A 4x5iA-5xbiA:
undetectable		 4x5iA-5xbiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbt PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		no annotation 3 ASP A 165
ARG A 123
ARG A 252
 None
 0.63A 4x5iA-5xbtA:
undetectable		 4x5iA-5xbtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xh9 EXTRACELLULAR
INVERTASE

(Aspergillus
kawachii) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 ASP A 336
ARG A 589
ARG A 525
 None
 0.82A 4x5iA-5xh9A:
undetectable		 4x5iA-5xh9A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoy [LYSW]-LYSINE
HYDROLASE

(Thermus
thermophilus) 		PF01546
(Peptidase_M20) 		3 ASP A  69
ARG A 216
ARG A 162
 None
None
LYS  A 401 (-4.4A)
 0.81A 4x5iA-5xoyA:
undetectable		 4x5iA-5xoyA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xs7 HEAVY CHAIN OF FAB
1D5
LIGHT CHAIN OF FAB
1D5

(Mus musculus;
Mus musculus) 		PF07686
(V-set)
PF07686
(V-set) 		3 ASP L   1
ARG H  75
ARG H  43
 None
 0.82A 4x5iA-5xs7L:
undetectable		 4x5iA-5xs7L:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 3 ASP A 436
ARG A1248
ARG A1196
 None
 0.98A 4x5iA-6bhuA:
undetectable		 4x5iA-6bhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dip NOCTURNIN

(Homo sapiens) 		no annotation 3 ASP A 234
ARG A 367
ARG A 290
 None
 0.64A 4x5iA-6dipA:
undetectable		 4x5iA-6dipA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehc OUTER MEMBRANE
PROTEIN U

(Vibrio cholerae) 		no annotation 3 ASP A 113
ARG A  44
ARG A  86
 None
 0.87A 4x5iA-6ehcA:
undetectable		 4x5iA-6ehcA:
undetectable