SIMILAR PATTERNS OF AMINO ACIDS FOR 4X3U_B_SVRB101_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pdq POLYCOMB PROTEIN

(Drosophila
melanogaster) 		PF00385
(Chromo) 		6 ARG A  35
TRP A  47
TYR A  54
THR A  56
TRP A  57
LEU A  64
 None
 0.73A 4x3uA-1pdqA:
7.8		 4x3uA-1pdqA:
44.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pdq POLYCOMB PROTEIN

(Drosophila
melanogaster) 		PF00385
(Chromo) 		6 TRP A  47
TRP A  50
TYR A  54
THR A  56
TRP A  57
LEU A  64
 None
 0.64A 4x3uA-1pdqA:
7.8		 4x3uA-1pdqA:
44.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pfb POLYCOMB PROTEIN

(Drosophila
melanogaster) 		PF00385
(Chromo) 		6 ARG A  35
TRP A  47
TYR A  54
THR A  56
TRP A  57
LEU A  64
 None
 0.79A 4x3uA-1pfbA:
8.7		 4x3uA-1pfbA:
51.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pfb POLYCOMB PROTEIN

(Drosophila
melanogaster) 		PF00385
(Chromo) 		6 TRP A  47
TRP A  50
TYR A  54
THR A  56
TRP A  57
LEU A  64
 None
 0.68A 4x3uA-1pfbA:
8.7		 4x3uA-1pfbA:
51.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2t CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 1

(Homo sapiens) 		PF00385
(Chromo) 		6 ARG A  23
LEU A  61
TRP A  64
TRP A  67
THR A  73
TRP A  74
 None
 0.44A 4x3uA-2b2tA:
5.8		 4x3uA-2b2tA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2y CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 1

(Homo sapiens) 		PF00385
(Chromo) 		5 ARG C  23
LEU C  61
TRP C  64
THR C  73
TRP C  74
 None
 0.28A 4x3uA-2b2yC:
5.4		 4x3uA-2b2yC:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2d9u CHROMOBOX PROTEIN
HOMOLOG 2 (ISOFORM
2)

(Homo sapiens) 		PF00385
(Chromo) 		5 ARG A  20
LEU A  29
TRP A  32
TRP A  35
TRP A  42
 None
 0.85A 4x3uA-2d9uA:
7.6		 4x3uA-2d9uA:
58.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2d9u CHROMOBOX PROTEIN
HOMOLOG 2 (ISOFORM
2)

(Homo sapiens) 		PF00385
(Chromo) 		5 ARG A  20
LEU A  29
TRP A  32
TRP A  42
LEU A  49
 None
 1.08A 4x3uA-2d9uA:
7.6		 4x3uA-2d9uA:
58.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dnv CHROMOBOX PROTEIN
HOMOLOG 8

(Mus musculus) 		PF00385
(Chromo) 		5 LEU A  29
TRP A  32
TRP A  35
THR A  41
TRP A  42
 None
 0.53A 4x3uA-2dnvA:
4.7		 4x3uA-2dnvA:
59.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dnv CHROMOBOX PROTEIN
HOMOLOG 8

(Mus musculus) 		PF00385
(Chromo) 		5 TRP A  32
TRP A  35
THR A  41
TRP A  42
LEU A  49
 None
 0.79A 4x3uA-2dnvA:
4.7		 4x3uA-2dnvA:
59.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1e CHROMO DOMAIN
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00385
(Chromo) 		5 ARG A  22
LEU A  50
THR A  62
TRP A  63
LEU A  75
 None
 1.00A 4x3uA-2h1eA:
5.3		 4x3uA-2h1eA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1e CHROMO DOMAIN
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00385
(Chromo) 		5 ARG A  22
LEU A  50
TRP A  53
THR A  62
TRP A  63
 None
 0.26A 4x3uA-2h1eA:
5.3		 4x3uA-2h1eA:
23.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2k1b CHROMOBOX PROTEIN
HOMOLOG 7

(Homo sapiens) 		PF00385
(Chromo) 		5 LEU A  22
TRP A  25
TYR A  32
THR A  34
TRP A  35
 None
 1.08A 4x3uA-2k1bA:
6.8		 4x3uA-2k1bA:
78.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2l1b CHROMOBOX PROTEIN
HOMOLOG 7

(Homo sapiens) 		PF00385
(Chromo) 		5 LEU A  23
TRP A  26
TRP A  29
TRP A  36
LEU A  43
 None
 1.02A 4x3uA-2l1bA:
7.8		 4x3uA-2l1bA:
93.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2l1b CHROMOBOX PROTEIN
HOMOLOG 7

(Homo sapiens) 		PF00385
(Chromo) 		6 LEU A  23
TRP A  26
TRP A  29
TYR A  33
THR A  35
TRP A  36
 None
 0.69A 4x3uA-2l1bA:
7.8		 4x3uA-2l1bA:
93.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2l1b CHROMOBOX PROTEIN
HOMOLOG 7

(Homo sapiens) 		PF00385
(Chromo) 		5 LEU A  23
TYR A  33
THR A  35
TRP A  36
HIS A  41
 None
 0.77A 4x3uA-2l1bA:
7.8		 4x3uA-2l1bA:
93.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cb5 FACT COMPLEX SUBUNIT
SPT16

(Schizosaccharomyces
pombe) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		5 ARG A  14
LEU A 173
TYR A  51
TRP A  60
LEU A 379
 None
 1.42A 4x3uA-3cb5A:
undetectable		 4x3uA-3cb5A:
10.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3f2u CHROMOBOX PROTEIN
HOMOLOG 1

(Homo sapiens) 		PF00385
(Chromo) 		5 ARG A  12
LEU A  21
TRP A  24
THR A  33
TRP A  34
 None
 0.20A 4x3uA-3f2uA:
7.1		 4x3uA-3f2uA:
43.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fdt CHROMOBOX PROTEIN
HOMOLOG 5

(Homo sapiens) 		PF00385
(Chromo) 		5 ARG A  13
LEU A  22
TRP A  25
THR A  34
TRP A  35
 None
 0.31A 4x3uA-3fdtA:
7.6		 4x3uA-3fdtA:
39.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gv6 CHROMOBOX PROTEIN
HOMOLOG 6

(Homo sapiens) 		PF00385
(Chromo) 		8 ARG A  20
LEU A  29
TRP A  32
TRP A  35
TYR A  39
THR A  41
TRP A  42
LEU A  49
 None
 0.68A 4x3uA-3gv6A:
9.3		 4x3uA-3gv6A:
69.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3h91 CHROMOBOX PROTEIN
HOMOLOG 2

(Homo sapiens) 		PF00385
(Chromo) 		6 ARG A  21
LEU A  30
TRP A  33
TRP A  36
TRP A  43
LEU A  50
 None
 0.66A 4x3uA-3h91A:
8.4		 4x3uA-3h91A:
66.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i8z E3 SUMO-PROTEIN
LIGASE CBX4

(Homo sapiens) 		PF00385
(Chromo) 		6 ARG A  20
LEU A  29
TRP A  32
TYR A  39
THR A  41
TRP A  42
 None
 0.60A 4x3uA-3i8zA:
4.9		 4x3uA-3i8zA:
73.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i90 CHROMOBOX PROTEIN
HOMOLOG 6

(Homo sapiens) 		PF00385
(Chromo) 		8 ARG A  20
LEU A  29
TRP A  32
TRP A  35
TYR A  39
THR A  41
TRP A  42
LEU A  49
 None
 0.64A 4x3uA-3i90A:
8.1		 4x3uA-3i90A:
63.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3i91 CHROMOBOX PROTEIN
HOMOLOG 8

(Homo sapiens) 		PF00385
(Chromo) 		8 ARG A  20
LEU A  29
TRP A  32
TRP A  35
TYR A  39
THR A  41
TRP A  42
LEU A  49
 None
 0.75A 4x3uA-3i91A:
8.5		 4x3uA-3i91A:
68.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hae CHROMODOMAIN Y-LIKE
PROTEIN 2

(Homo sapiens) 		PF00385
(Chromo) 		5 ARG A  16
LEU A  26
TRP A  29
THR A  38
TRP A  39
 None
 0.31A 4x3uA-4haeA:
4.3		 4x3uA-4haeA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4quf RE36324P

(Drosophila
melanogaster) 		PF00385
(Chromo) 		5 ARG A  33
LEU A  42
TRP A  45
THR A  54
TRP A  55
 None
 0.23A 4x3uA-4qufA:
8.6		 4x3uA-4qufA:
38.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u68 RHINO

(Drosophila
melanogaster) 		PF00385
(Chromo) 		5 ARG A  33
LEU A  42
TRP A  45
THR A  54
TRP A  55
 None
 0.30A 4x3uA-4u68A:
8.6		 4x3uA-4u68A:
40.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e4w SIGNAL RECOGNITION
PARTICLE 43 KDA
PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00385
(Chromo) 		5 ARG C 329
LEU C 340
TRP C 343
THR C 350
TRP C 351
 None
 0.36A 4x3uA-5e4wC:
6.4		 4x3uA-5e4wC:
38.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ejw CHROMOBOX PROTEIN
HOMOLOG 7

(Mus musculus) 		PF00385
(Chromo) 		9 ARG A  20
LEU A  29
TRP A  32
TRP A  35
TYR A  39
THR A  41
TRP A  42
HIS A  47
LEU A  49
 None
None
5PZ  A 101 (-3.6A)
5PZ  A 101 (-4.1A)
None
5PZ  A 101 (-3.5A)
None
None
None
 0.68A 4x3uA-5ejwA:
8.4		 4x3uA-5ejwA:
92.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 6 ARG W 186
LEU W 214
TRP W 217
THR W 226
TRP W 227
LEU W 239
 None
 0.83A 4x3uA-5o9gW:
7.9		 4x3uA-5o9gW:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ftx -

(-) 		no annotation 5 LEU W 214
TRP W 217
THR W 226
TRP W 227
LEU W 239
 None
 0.76A 4x3uA-6ftxW:
4.7		 4x3uA-6ftxW:
undetectable