SIMILAR PATTERNS OF AMINO ACIDS FOR 4X3M_A_ADNA301_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b8x | PROTEIN (AML-1B) (Escherichiacoli) |
PF02798(GST_N)PF14497(GST_C_3) | 5 | LEU A 4GLY A 5ILE A 71SER A 67THR A 16 | None | 1.08A | 4x3mA-1b8xA:undetectable | 4x3mA-1b8xA:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bg5 | FUSION PROTEIN OFALPHA-NA,K-ATPASEWITH GLUTATHIONES-TRANSFERASE (Rattusnorvegicus) |
PF02798(GST_N)PF14497(GST_C_3) | 5 | LEU A 5GLY A 6ILE A 75VAL A 14THR A 17 | None | 1.29A | 4x3mA-1bg5A:undetectable | 4x3mA-1bg5A:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c3c | PROTEIN(ADENYLOSUCCINATELYASE) (Thermotogamaritima) |
PF00206(Lyase_1)PF10397(ADSL_C) | 5 | LEU A 204GLY A 203GLU A 25ILE A 180THR A 100 | None | 1.45A | 4x3mA-1c3cA:undetectable | 4x3mA-1c3cA:23.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d1t | ALCOHOLDEHYDROGENASE CLASSIV SIGMA CHAIN (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | PRO A 243LEU A 200GLY A 199ILE A 241VAL A 197 | NoneNoneNAD A1377 ( 3.7A)NoneNone | 1.10A | 4x3mA-1d1tA:2.8 | 4x3mA-1d1tA:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dof | ADENYLOSUCCINATELYASE (Pyrobaculumaerophilum) |
PF00206(Lyase_1) | 5 | LEU A 208GLY A 207GLU A 30ILE A 181THR A 102 | None | 1.42A | 4x3mA-1dofA:undetectable | 4x3mA-1dofA:25.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f20 | NITRIC-OXIDESYNTHASE (Rattusnorvegicus) |
PF00175(NAD_binding_1)PF00667(FAD_binding_1) | 5 | PRO A1205LEU A1043GLU A1151VAL A1147THR A1145 | None | 1.46A | 4x3mA-1f20A:undetectable | 4x3mA-1f20A:22.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ipa | RNA 2'-O-RIBOSEMETHYLTRANSFERASE (Thermusthermophilus) |
PF00588(SpoU_methylase)PF08032(SpoU_sub_bind) | 5 | GLY A 215ILE A 235MET A 237SER A 243VAL A 246 | None | 0.73A | 4x3mA-1ipaA:25.3 | 4x3mA-1ipaA:53.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j0n | XANTHAN LYASE (Bacillus sp.GL1) |
PF02278(Lyase_8)PF02884(Lyase_8_C)PF08124(Lyase_8_N) | 5 | GLY A 194ILE A 202MET A 156VAL A 259THR A 262 | None | 1.10A | 4x3mA-1j0nA:undetectable | 4x3mA-1j0nA:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jqo | PHOSPHOENOLPYRUVATECARBOXYLASE (Zea mays) |
PF00311(PEPcase) | 5 | LEU A 83GLY A 84ILE A 102VAL A 903THR A 900 | None | 1.21A | 4x3mA-1jqoA:2.6 | 4x3mA-1jqoA:15.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lac | DIHYDROLIPOAMIDEACETYLTRANSFERASE (Geobacillusstearothermophilus) |
PF00364(Biotin_lipoyl) | 5 | LEU A 75GLY A 53GLU A 31ILE A 47VAL A 51 | None | 1.24A | 4x3mA-1lacA:undetectable | 4x3mA-1lacA:16.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q3t | CYTIDYLATE KINASE (Streptococcuspneumoniae) |
PF02224(Cytidylate_kin) | 5 | LEU A 59ILE A 115SER A 113VAL A 108THR A 55 | None | 1.43A | 4x3mA-1q3tA:undetectable | 4x3mA-1q3tA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r1a | HUMAN RHINOVIRUS 1ACOAT PROTEIN(SUBUNIT VP1)HUMAN RHINOVIRUS 1ACOAT PROTEIN(SUBUNIT VP2) (Rhinovirus A) |
PF00073(Rhv) | 5 | LEU 2 173GLY 2 177ILE 1 278VAL 1 257THR 1 276 | None | 1.25A | 4x3mA-1r1a2:undetectable | 4x3mA-1r1a2:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u3t | ALCOHOLDEHYDROGENASE ALPHACHAIN (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | PRO A 243LEU A 200GLY A 199ILE A 241VAL A 197 | NoneNoneNAD A1377 (-3.5A)NoneNone | 1.19A | 4x3mA-1u3tA:2.6 | 4x3mA-1u3tA:22.45 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1v2x | TRNA (GM18)METHYLTRANSFERASE (Thermusthermophilus) |
PF00588(SpoU_methylase)PF12105(SpoU_methylas_C) | 5 | GLY A 122ILE A 142MET A 144SER A 150VAL A 153 | SAM A 400 (-3.2A)SAM A 400 (-3.6A)SAM A 400 (-3.3A)SAM A 400 ( 3.7A)SAM A 400 (-3.9A) | 0.43A | 4x3mA-1v2xA:18.7 | 4x3mA-1v2xA:30.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v33 | DNA PRIMASE SMALLSUBUNIT (Pyrococcushorikoshii) |
PF01896(DNA_primase_S) | 5 | PRO A 256LEU A 264GLY A 260ILE A 242SER A 234 | None | 1.21A | 4x3mA-1v33A:undetectable | 4x3mA-1v33A:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v5b | 3-ISOPROPYLMALATEDEHYDROGENASE (Bacilluscoagulans) |
PF00180(Iso_dh) | 5 | LEU A 248GLY A 245SER A 187VAL A 221THR A 224 | None | 0.99A | 4x3mA-1v5bA:2.1 | 4x3mA-1v5bA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vbg | PYRUVATE,ORTHOPHOSPHATE DIKINASE (Zea mays) |
PF00391(PEP-utilizers)PF01326(PPDK_N)PF02896(PEP-utilizers_C) | 5 | LEU A 719GLY A 720ILE A 749VAL A 710THR A 747 | None | 1.48A | 4x3mA-1vbgA:undetectable | 4x3mA-1vbgA:15.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vjo | ALANINE--GLYOXYLATEAMINOTRANSFERASE (Nostoc sp. PCC7120) |
PF00266(Aminotran_5) | 5 | PRO A 28LEU A 314GLY A 161GLU A 157THR A 186 | NoneNoneNoneNonePLP A 400 (-4.5A) | 1.04A | 4x3mA-1vjoA:undetectable | 4x3mA-1vjoA:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vkz | PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (Thermotogamaritima) |
PF01071(GARS_A)PF02843(GARS_C)PF02844(GARS_N) | 5 | GLY A 19GLU A 15ILE A 286MET A 188THR A 283 | None | 1.37A | 4x3mA-1vkzA:2.9 | 4x3mA-1vkzA:23.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wcg | THIOGLUCOSIDASE (Brevicorynebrassicae) |
PF00232(Glyco_hydro_1) | 5 | LEU A 434GLY A 433ILE A 68VAL A 415THR A 13 | None | 1.50A | 4x3mA-1wcgA:2.8 | 4x3mA-1wcgA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zjr | TRNA(GUANOSINE-2'-O-)-METHYLTRANSFERASE (Aquifexaeolicus) |
PF00588(SpoU_methylase)PF12105(SpoU_methylas_C) | 5 | GLY A 126ILE A 146MET A 148SER A 154VAL A 157 | GOL A 529 (-4.0A)NoneNoneGOL A 529 (-3.5A)GOL A 529 (-3.7A) | 0.63A | 4x3mA-1zjrA:15.4 | 4x3mA-1zjrA:24.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a3n | PUTATIVEGLUCOSAMINE-FRUCTOSE-6-PHOSPHATEAMINOTRANSFERASE (Salmonellaenterica) |
PF01380(SIS) | 5 | LEU A 131GLY A 101MET A 57SER A 53THR A 96 | None | 1.42A | 4x3mA-2a3nA:2.5 | 4x3mA-2a3nA:22.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dm4 | SORTILIN-RELATEDRECEPTOR (Homo sapiens) |
PF00041(fn3) | 5 | PRO A 19GLY A 102ILE A 26VAL A 72THR A 99 | None | 1.28A | 4x3mA-2dm4A:undetectable | 4x3mA-2dm4A:16.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eel | CELL DEATH ACTIVATORCIDE-A (Homo sapiens) |
PF02017(CIDE-N) | 5 | LEU A 33ILE A 76SER A 15VAL A 25THR A 37 | None | 1.35A | 4x3mA-2eelA:undetectable | 4x3mA-2eelA:16.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fzw | ALCOHOLDEHYDROGENASE CLASSIII CHI CHAIN (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | PRO A 242LEU A 199GLY A 198ILE A 240VAL A 196 | NoneNoneNAD A1377 (-3.6A)NoneNone | 1.11A | 4x3mA-2fzwA:3.0 | 4x3mA-2fzwA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ha8 | TAR (HIV-1) RNA LOOPBINDING PROTEIN (Homo sapiens) |
PF00588(SpoU_methylase) | 5 | LEU A 128GLY A 129ILE A 149SER A 157VAL A 160 | SAH A 401 ( 4.6A)SAH A 401 (-3.1A)SAH A 401 (-3.8A)SAH A 401 ( 3.8A)SAH A 401 (-3.6A) | 0.92A | 4x3mA-2ha8A:19.8 | 4x3mA-2ha8A:26.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vsm | HEMAGGLUTININ-NEURAMINIDASE (Nipahhenipavirus) |
PF00423(HN) | 5 | PRO A 273LEU A 319GLY A 251VAL A 293THR A 317 | None | 1.08A | 4x3mA-2vsmA:undetectable | 4x3mA-2vsmA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ynm | LIGHT-INDEPENDENTPROTOCHLOROPHYLLIDEREDUCTASE SUBUNIT B (Prochlorococcusmarinus) |
PF00148(Oxidored_nitro)PF08369(PCP_red) | 5 | LEU D 120GLY D 92ILE D 19MET D 23THR D 136 | None | 1.36A | 4x3mA-2ynmD:undetectable | 4x3mA-2ynmD:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cru | GLUTATHIONES-TRANSFERASECLASS-MU 26 KDAISOZYME (Schistosomajaponicum) |
PF02798(GST_N)PF14497(GST_C_3) | 5 | LEU A 5GLY A 6ILE A 75VAL A 14THR A 17 | None | 1.16A | 4x3mA-3cruA:undetectable | 4x3mA-3cruA:24.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e48 | PUTATIVENUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE (Staphylococcusaureus) |
PF13460(NAD_binding_10) | 5 | PRO A 163GLY A 240GLU A 231ILE A 161SER A 225 | None | 1.13A | 4x3mA-3e48A:2.7 | 4x3mA-3e48A:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fah | ALDEHYDEOXIDOREDUCTASE (Desulfovibriogigas) |
PF00111(Fer2)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2) | 5 | LEU A 85ILE A 76SER A 104VAL A 186THR A 190 | NoneNoneFES A 908 ( 4.7A)NoneNone | 1.30A | 4x3mA-3fahA:undetectable | 4x3mA-3fahA:15.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fed | GLUTAMATECARBOXYPEPTIDASE III (Homo sapiens) |
PF02225(PA)PF04253(TFR_dimer)PF04389(Peptidase_M28) | 5 | LEU A 299GLY A 322ILE A 216MET A 334VAL A 165 | None | 1.47A | 4x3mA-3fedA:2.4 | 4x3mA-3fedA:16.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gyq | RRNA(ADENOSINE-2'-O-)-METHYLTRANSFERASE (Streptomycescyaneus) |
PF00588(SpoU_methylase)PF04705(TSNR_N) | 5 | GLY A 218ILE A 238MET A 240SER A 246VAL A 249 | SAM A 270 (-2.9A)SAM A 270 (-3.5A)SAM A 270 (-3.5A)SAM A 270 (-2.8A)SAM A 270 ( 4.2A) | 0.91A | 4x3mA-3gyqA:22.8 | 4x3mA-3gyqA:29.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kzu | 3-OXOACYL-(ACYL-CARRIER-PROTEIN)SYNTHASE II (Brucellamelitensis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | LEU A 9GLY A 8ILE A 364VAL A 358THR A 361 | None | 1.45A | 4x3mA-3kzuA:undetectable | 4x3mA-3kzuA:24.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lcc | PUTATIVE METHYLCHLORIDE TRANSFERASE (Arabidopsisthaliana) |
PF05724(TPMT) | 5 | LEU A 220GLY A 221GLU A 166ILE A 56MET A 84 | None | 1.36A | 4x3mA-3lccA:undetectable | 4x3mA-3lccA:22.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3nk7 | 23S RRNAMETHYLTRANSFERASE (Streptomycesactuosus) |
PF00588(SpoU_methylase)PF04705(TSNR_N) | 5 | GLY A 218ILE A 238MET A 240SER A 246VAL A 249 | SAM A 770 (-3.0A)SAM A 770 (-3.8A)SAM A 770 (-3.3A)SAM A 770 (-3.9A)SAM A 770 (-3.7A) | 0.64A | 4x3mA-3nk7A:24.9 | 4x3mA-3nk7A:30.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3noy | 4-HYDROXY-3-METHYLBUT-2-EN-1-YLDIPHOSPHATE SYNTHASE (Aquifexaeolicus) |
PF04551(GcpE) | 5 | LEU A 235GLY A 208ILE A 249VAL A 241THR A 245 | None | 1.39A | 4x3mA-3noyA:undetectable | 4x3mA-3noyA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qnq | PTS SYSTEM,CELLOBIOSE-SPECIFICIIC COMPONENT (Bacillus cereus) |
PF02378(PTS_EIIC) | 5 | LEU A 106GLY A 190ILE A 152VAL A 194THR A 110 | None | 1.27A | 4x3mA-3qnqA:undetectable | 4x3mA-3qnqA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r4t | 4-AMINOBUTYRATEAMINOTRANSFERASEGABT (Mycobacteriummarinum) |
PF00202(Aminotran_3) | 5 | GLY A 296ILE A 338MET A 343VAL A 77THR A 334 | LLP A 291 ( 4.9A)NoneNoneNoneNone | 1.29A | 4x3mA-3r4tA:undetectable | 4x3mA-3r4tA:24.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sdo | NITRILOTRIACETATEMONOOXYGENASE (Burkholderiapseudomallei) |
PF00296(Bac_luciferase) | 5 | PRO A 271LEU A 401GLY A 400MET A 378VAL A 405 | None | 1.44A | 4x3mA-3sdoA:3.8 | 4x3mA-3sdoA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tr9 | DIHYDROPTEROATESYNTHASE (Coxiellaburnetii) |
PF00809(Pterin_bind) | 5 | GLY A 32GLU A 61ILE A 257VAL A 276THR A 279 | None | 1.45A | 4x3mA-3tr9A:3.6 | 4x3mA-3tr9A:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uho | GLUTAMATE RACEMASE (Campylobacterjejuni) |
PF01177(Asp_Glu_race) | 5 | LEU A 13GLY A 12GLU A 150ILE A 243THR A 240 | None | 1.44A | 4x3mA-3uhoA:undetectable | 4x3mA-3uhoA:22.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vsc | PROTEIN CYSO (Aeropyrumpernix) |
PF00291(PALP) | 5 | PRO A 368LEU A 114MET A 266SER A 259VAL A 346 | PLP A 401 (-4.1A)NoneNonePLP A 401 (-3.4A)None | 1.49A | 4x3mA-3vscA:undetectable | 4x3mA-3vscA:23.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vyl | L-RIBULOSE3-EPIMERASE (Mesorhizobiumloti) |
PF01261(AP_endonuc_2) | 5 | LEU A 59GLY A 60ILE A 6SER A 8THR A 27 | None | 1.45A | 4x3mA-3vylA:3.0 | 4x3mA-3vylA:24.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zyt | ESTERASE A (Paenarthrobacternitroguajacolicus) |
PF00144(Beta-lactamase) | 5 | LEU A 265GLU A 252ILE A 177MET A 64THR A 181 | None | 1.31A | 4x3mA-3zytA:undetectable | 4x3mA-3zytA:25.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bva | THIOMORPHOLINE-CARBOXYLATE DEHYDROGENASE (Mus musculus) |
PF02423(OCD_Mu_crystall) | 5 | LEU A 23GLU A 69ILE A 114MET A 109VAL A 300 | None | 1.38A | 4x3mA-4bvaA:2.4 | 4x3mA-4bvaA:23.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e8o | AAC(6')-IH PROTEIN (Acinetobacterbaumannii) |
PF00583(Acetyltransf_1) | 5 | LEU A 130GLY A 131GLU A 101VAL A 97THR A 94 | None | 1.37A | 4x3mA-4e8oA:undetectable | 4x3mA-4e8oA:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ilq | CT771 (Chlamydiatrachomatis) |
PF00293(NUDIX) | 5 | PRO A 14GLY A 67ILE A 31VAL A 61THR A 64 | None | 1.28A | 4x3mA-4ilqA:undetectable | 4x3mA-4ilqA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ilq | CT771 (Chlamydiatrachomatis) |
PF00293(NUDIX) | 5 | PRO A 52GLY A 44ILE A 75VAL A 94THR A 95 | NoneSO4 A 201 (-3.2A)NoneNoneNone | 1.41A | 4x3mA-4ilqA:undetectable | 4x3mA-4ilqA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iu9 | NITRITE EXTRUSIONPROTEIN 2 (Escherichiacoli) |
no annotation | 5 | PRO B 296LEU B 174GLY B 175ILE B 298MET B 353 | None | 1.34A | 4x3mA-4iu9B:undetectable | 4x3mA-4iu9B:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nvt | TRIOSEPHOSPHATEISOMERASE (Brucellamelitensis) |
PF00121(TIM) | 5 | LEU A 65GLY A 66ILE A 28SER A 238VAL A 46 | None | 1.27A | 4x3mA-4nvtA:3.6 | 4x3mA-4nvtA:25.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o99 | ACETYL-COAACETYLTRANSFERASE (Cupriavidusnecator) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | PRO A 65GLY A 54GLU A 116SER A 61VAL A 56 | None | 1.38A | 4x3mA-4o99A:undetectable | 4x3mA-4o99A:24.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ptf | DNA POLYMERASEEPSILON CATALYTICSUBUNIT A (Saccharomycescerevisiae) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1) | 5 | LEU A 515GLY A 511ILE A 493MET A 420THR A 507 | None | 1.46A | 4x3mA-4ptfA:undetectable | 4x3mA-4ptfA:12.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pzk | TRNA(CYTIDINE(34)-2'-O)-METHYLTRANSFERASE (Bacillusanthracis) |
PF00588(SpoU_methylase) | 5 | GLY A 104ILE A 125MET A 127SER A 133THR A 139 | SAH A 201 (-3.1A)SAH A 201 (-3.9A)SAH A 201 (-3.3A)SAH A 201 ( 3.8A)SAH A 201 (-3.6A) | 0.76A | 4x3mA-4pzkA:17.6 | 4x3mA-4pzkA:25.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u0p | LIPOYL SYNTHASE 2 (Thermosynechococcuselongatus) |
PF04055(Radical_SAM) | 5 | PRO B 179GLY B 214GLU B 219VAL B 173THR B 172 | None | 1.42A | 4x3mA-4u0pB:undetectable | 4x3mA-4u0pB:24.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wr4 | GLUTATHIONES-TRANSFERASECLASS-MU 26 KDAISOZYME (Schistosomajaponicum) |
PF02798(GST_N)PF14497(GST_C_3) | 5 | LEU A 4GLY A 5ILE A 74VAL A 13THR A 16 | BYR A 57 ( 4.4A)BYR A 32 ( 4.5A)BYR A 73 ( 4.3A)NoneNone | 1.16A | 4x3mA-4wr4A:undetectable | 4x3mA-4wr4A:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xsv | ETHANOLAMINE-PHOSPHATECYTIDYLYLTRANSFERASE (Homo sapiens) |
PF01467(CTP_transf_like) | 5 | LEU A 249GLY A 248GLU A 283VAL A 284THR A 272 | None | 1.40A | 4x3mA-4xsvA:undetectable | 4x3mA-4xsvA:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cnx | AMINOPEPTIDASE YPDF (Escherichiacoli) |
PF00557(Peptidase_M24)PF01321(Creatinase_N) | 5 | PRO A 194GLY A 330ILE A 184VAL A 332THR A 210 | None | 1.37A | 4x3mA-5cnxA:undetectable | 4x3mA-5cnxA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5co4 | PUTATIVE TRNA(CYTIDINE(34)-2'-O)-METHYLTRANSFERASE (Thermusthermophilus) |
no annotation | 5 | GLY B 101GLU B 103ILE B 120MET B 122SER B 128 | MTA B 401 (-3.2A)MTA B 401 (-4.3A)MTA B 401 (-3.7A)MTA B 401 (-3.4A)MTA B 401 ( 3.9A) | 0.62A | 4x3mA-5co4B:19.1 | 4x3mA-5co4B:26.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jtk | UNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
no annotation | 5 | PRO A 3LEU A 51GLY A 86ILE A 7VAL A 40 | None | 1.01A | 4x3mA-5jtkA:undetectable | 4x3mA-5jtkA:18.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k1s | OXIDOREDUCTASE,ZINC-BINDINGDEHYDROGENASE FAMILY (Myxococcusxanthus) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 220ILE A 242SER A 176VAL A 197THR A 173 | None | 1.43A | 4x3mA-5k1sA:2.3 | 4x3mA-5k1sA:26.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kp8 | CURB (Lyngbyamajuscula) |
PF00550(PP-binding) | 5 | LEU B 26GLU B 22ILE B 45MET B 48THR B 14 | None | 1.38A | 4x3mA-5kp8B:undetectable | 4x3mA-5kp8B:17.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m85 | SENSORY TRANSDUCTIONHISTIDINE KINASE (Synechocystissp. PCC 6803) |
no annotation | 5 | LEU A 556GLY A 557SER A 478VAL A 452THR A 448 | None | 1.41A | 4x3mA-5m85A:undetectable | 4x3mA-5m85A:14.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n1x | B-CELL LYMPHOMA 6PROTEIN (Homo sapiens) |
PF00651(BTB) | 5 | PRO D 80LEU D 86ILE D 78VAL D 105THR D 108 | None | 1.15A | 4x3mA-5n1xD:undetectable | 4x3mA-5n1xD:19.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n9j | MEDIATOR COMPLEXSUBUNIT 9MEDIATOR OF RNAPOLYMERASE IITRANSCRIPTIONSUBUNIT 4 (Schizosaccharomycespombe) |
PF10018(Med4)no annotation | 5 | LEU G 57GLY G 54GLU F 67ILE F 76VAL F 70 | None | 1.43A | 4x3mA-5n9jG:undetectable | 4x3mA-5n9jG:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oki | DNA POLYMERASEEPSILON CATALYTICSUBUNIT A (Saccharomycescerevisiae) |
no annotation | 5 | LEU A 515GLY A 511ILE A 493MET A 420THR A 507 | None | 1.46A | 4x3mA-5okiA:undetectable | 4x3mA-5okiA:14.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u09 | CANNABINOID RECEPTOR1,GLGA GLYCOGENSYNTHASE (Homo sapiens;Pyrococcusabyssi) |
PF00001(7tm_1)PF00534(Glycos_transf_1) | 5 | PRO A 394LEU A 138GLY A 157SER A 390VAL A 161 | SO4 A1209 (-4.7A)NoneNone7DY A1210 ( 4.1A)None | 1.45A | 4x3mA-5u09A:4.2 | 4x3mA-5u09A:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u7z | ACID CERAMIDASE (Homo sapiens) |
no annotation | 5 | LEU B 307GLY B 291ILE B 349MET B 354VAL B 316 | None | 1.15A | 4x3mA-5u7zB:undetectable | 4x3mA-5u7zB:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ve8 | KAP123 (Kluyveromyceslactis) |
no annotation | 5 | LEU A 853GLY A 856ILE A 788SER A 794VAL A 860 | None | 1.45A | 4x3mA-5ve8A:undetectable | 4x3mA-5ve8A:13.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y0m | - (-) |
no annotation | 5 | GLY A 199ILE A 298MET A 294VAL A 217THR A 268 | None | 1.44A | 4x3mA-5y0mA:undetectable | 4x3mA-5y0mA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yjp | HUMAN CHYMASE (Homo sapiens) |
no annotation | 5 | PRO A 198LEU A 33ILE A 212VAL A 52THR A 54 | None | 1.45A | 4x3mA-5yjpA:undetectable | 4x3mA-5yjpA:15.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dft | - (-) |
no annotation | 5 | LEU A 370GLY A 371GLU A 431ILE A 439VAL A 432 | NoneNAD A 502 (-3.8A)NAD A 502 (-4.0A)NoneNAD A 502 (-4.1A) | 1.50A | 4x3mA-6dftA:2.5 | 4x3mA-6dftA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6eub | ANGIOPOIETIN-RELATEDPROTEIN 4 (Homo sapiens) |
no annotation | 5 | LEU A 257GLY A 258ILE A 204SER A 209VAL A 262 | None | 1.33A | 4x3mA-6eubA:undetectable | 4x3mA-6eubA:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f42 | DNA-DIRECTED RNAPOLYMERASE IIISUBUNIT RPC1 (Saccharomycescerevisiae) |
no annotation | 5 | LEU A 242GLY A 243GLU A 240ILE A 234SER A 236 | None | 1.37A | 4x3mA-6f42A:undetectable | 4x3mA-6f42A:14.40 |