SIMILAR PATTERNS OF AMINO ACIDS FOR 4X30_A_T44A401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b5l INTERFERON TAU

(Komagataella
pastoris) 		PF00143
(Interferon) 		5 ALA A 151
GLN A  90
LEU A  93
ASN A  66
LEU A  61
 None
 1.20A 4x30A-1b5lA:
0.7		 4x30A-1b5lA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		5 ALA A 289
LEU A 275
LEU A 262
LEU A 278
ARG A 279
 None
 1.49A 4x30A-1crlA:
0.0		 4x30A-1crlA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		5 ALA A 311
GLN A 360
LEU A 308
ASN A 300
LEU A 356
 None
 1.03A 4x30A-1dj2A:
undetectable		 4x30A-1dj2A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		5 ALA A 511
GLN A  35
LEU A 579
ASN A  37
LEU A  44
 None
 1.45A 4x30A-1flgA:
0.0		 4x30A-1flgA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyq CELL DIVISION
INHIBITOR (MIND-1)

(Archaeoglobus
fulgidus) 		PF01656
(CbiA) 		5 ALA A 132
LEU A  63
LEU A  89
LEU A 100
ARG A  93
 None
 1.44A 4x30A-1hyqA:
0.0		 4x30A-1hyqA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l7v VITAMIN B12
TRANSPORT
ATP-BINDING PROTEIN
BTUD

(Escherichia
coli) 		PF00005
(ABC_tran) 		5 ALA C 148
LEU C  94
LEU C 106
ASN C 108
LEU C 142
 None
 1.44A 4x30A-1l7vC:
0.0		 4x30A-1l7vC:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m59 CYTOCHROME B5

(Bos taurus) 		PF00173
(Cyt-b5) 		5 ALA A  54
LEU A  36
LEU A  23
LEU A  46
ARG A  47
 HEM  A 201 ( 4.1A)
None
None
None
None
 1.25A 4x30A-1m59A:
undetectable		 4x30A-1m59A:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oaa SEPIAPTERIN
REDUCTASE

(Mus musculus) 		PF00106
(adh_short) 		5 ALA A 239
LEU A  32
LEU A 243
LEU A  28
ARG A  30
 None
 1.46A 4x30A-1oaaA:
0.0		 4x30A-1oaaA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vd6 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Thermus
thermophilus) 		PF03009
(GDPD) 		5 ALA A 111
LEU A 147
LEU A 115
LEU A 138
ARG A 139
 None
 1.36A 4x30A-1vd6A:
0.0		 4x30A-1vd6A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd5 HYPOTHETICAL PROTEIN
TT1426

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		5 ALA A 170
LEU A  28
LEU A 140
LEU A 125
ARG A 118
 None
 1.42A 4x30A-1wd5A:
0.0		 4x30A-1wd5A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ALA A 102
LEU A 133
LEU A  99
LEU A 178
ARG A 180
 None
 1.09A 4x30A-1xkwA:
undetectable		 4x30A-1xkwA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ys2 LIPASE

(Burkholderia
cepacia) 		PF00561
(Abhydrolase_1) 		5 ALA X  97
LEU X  49
LEU X  83
LEU X  65
ARG X  61
 None
 1.26A 4x30A-1ys2X:
undetectable		 4x30A-1ys2X:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysr SENSOR-TYPE
HISTIDINE KINASE
PRRB

(Mycobacterium
tuberculosis) 		PF02518
(HATPase_c) 		5 ALA A 426
LEU A 410
LEU A 438
LEU A 412
ARG A 390
 None
 1.19A 4x30A-1ysrA:
undetectable		 4x30A-1ysrA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bku IMPORTIN BETA-1
SUBUNIT

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		5 ALA B  41
GLN B 117
LEU B  69
ASN B  67
LEU B 118
 None
 1.48A 4x30A-2bkuB:
undetectable		 4x30A-2bkuB:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg5 FATTY ACID SYNTHASE

(Homo sapiens) 		PF00550
(PP-binding) 		5 ALA B2130
LEU B2172
LEU B2127
LYS B2124
LEU B2166
 None
 1.41A 4x30A-2cg5B:
undetectable		 4x30A-2cg5B:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy0 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE

(Escherichia
coli) 		PF00156
(Pribosyltran) 		5 ALA A 153
GLN A   7
LEU A  48
LEU A 177
ARG A  51
 None
 1.45A 4x30A-2dy0A:
undetectable		 4x30A-2dy0A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epg HYPOTHETICAL PROTEIN
TTHA1785

(Thermus
thermophilus) 		PF01139
(RtcB) 		5 GLN A 368
LEU A 326
LEU A 323
LEU A 371
ARG A 101
 None
 1.45A 4x30A-2epgA:
undetectable		 4x30A-2epgA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu0 TYROSINE-PROTEIN
KINASE ITK/TSK

(Mus musculus) 		PF00017
(SH2) 		5 ALA A  79
GLN A  92
LEU A  89
ASN A  97
LEU A  90
 None
 1.10A 4x30A-2eu0A:
undetectable		 4x30A-2eu0A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1q ARGININE KINASE

(Trypanosoma
cruzi) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 ALA A  69
GLN A  99
LEU A 331
LEU A 268
LEU A 275
 None
 1.31A 4x30A-2j1qA:
undetectable		 4x30A-2j1qA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5t GLUTAMATE 5-KINASE

(Escherichia
coli) 		PF00696
(AA_kinase)
PF01472
(PUA) 		5 ALA A  55
LEU A  90
LEU A  23
ASN A  24
LEU A  86
 None
 1.45A 4x30A-2j5tA:
undetectable		 4x30A-2j5tA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq2 HYPOTHETICAL ABC
TRANSPORTER
ATP-BINDING PROTEIN
HI1470

(Haemophilus
influenzae) 		PF00005
(ABC_tran) 		5 ALA C 109
GLN C 133
LEU C 129
LEU C 113
ARG C 124
 None
 1.24A 4x30A-2nq2C:
undetectable		 4x30A-2nq2C:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0r RV0858C
(N-SUCCINYLDIAMINOPI
MELATE
AMINOTRANSFERASE)

(Mycobacterium
tuberculosis) 		PF00155
(Aminotran_1_2) 		5 ALA A 320
LEU A 381
LEU A 318
LEU A 298
ARG A 297
 None
 1.30A 4x30A-2o0rA:
undetectable		 4x30A-2o0rA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3e DIAMINOPIMELATE
DECARBOXYLASE

(Aquifex
aeolicus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 LEU A  25
LEU A   4
LYS A   5
ASN A   8
LEU A  18
 None
 1.32A 4x30A-2p3eA:
undetectable		 4x30A-2p3eA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmp 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF02542
(YgbB) 		5 ALA A 125
LEU A  43
ASN A 131
LEU A 119
ARG A 116
 None
 1.15A 4x30A-2pmpA:
undetectable		 4x30A-2pmpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5c NTRC FAMILY
TRANSCRIPTIONAL
REGULATOR

(Clostridium
acetobutylicum) 		PF06506
(PrpR_N) 		5 ALA A 174
LEU A  15
LEU A 171
LEU A   7
ARG A  56
 None
None
None
None
GOL  A 701 ( 4.3A)
 1.25A 4x30A-2q5cA:
undetectable		 4x30A-2q5cA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhg TYROCIDINE
SYNTHETASE A

(Brevibacillus
brevis) 		PF00668
(Condensation) 		5 ALA A 266
LEU A 248
LEU A 263
ASN A 260
LEU A 247
 None
 1.48A 4x30A-2xhgA:
undetectable		 4x30A-2xhgA:
21.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		5 ALA A  27
GLN A 238
LEU A 246
LEU A 269
ASN A 273
 T44  A1370 ( 3.9A)
T44  A1370 (-3.3A)
T44  A1370 (-4.6A)
T44  A1370 (-4.0A)
T44  A1370 ( 3.3A)
 0.35A 4x30A-2xn6A:
41.3		 4x30A-2xn6A:
88.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpz LEUKOTRIENE A-4
HYDROLASE

(Saccharomyces
cerevisiae) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 ALA A 517
GLN A 606
LEU A 583
LEU A 557
LEU A 582
 None
 1.29A 4x30A-2xpzA:
undetectable		 4x30A-2xpzA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvx CHELATASE, PUTATIVE

(Desulfovibrio
vulgaris) 		PF06180
(CbiK) 		5 ALA A  47
LEU A 112
LEU A  13
LEU A  71
ARG A  45
 None
None
None
None
SO4  A1274 (-2.8A)
 1.27A 4x30A-2xvxA:
undetectable		 4x30A-2xvxA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE

(Pyrococcus
furiosus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 ALA A 361
LEU A 457
LEU A 357
LEU A 453
ARG A 359
 None
 1.44A 4x30A-3a2fA:
undetectable		 4x30A-3a2fA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3crj TRANSCRIPTION
REGULATOR

(Haloarcula
marismortui) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		5 ALA A 106
GLN A  18
LEU A 103
ARG A  22
ARG A  25
 None
 1.40A 4x30A-3crjA:
undetectable		 4x30A-3crjA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cuc PROTEIN OF UNKNOWN
FUNCTION WITH A FIC
DOMAIN

(Bacteroides
thetaiotaomicron) 		PF02661
(Fic) 		5 ALA A  65
LEU A  56
LEU A  47
ASN A  40
LEU A  55
 None
 1.49A 4x30A-3cucA:
undetectable		 4x30A-3cucA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE

(Bacillus
subtilis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 ALA A 184
GLN A 273
LEU A 266
LEU A 221
ARG A 219
 None
 1.24A 4x30A-3egoA:
undetectable		 4x30A-3egoA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fed GLUTAMATE
CARBOXYPEPTIDASE III

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 ALA A 521
LEU A 736
LEU A 459
ASN A 586
LEU A 661
 None
 1.37A 4x30A-3fedA:
undetectable		 4x30A-3fedA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gka N-ETHYLMALEIMIDE
REDUCTASE

(Burkholderia
pseudomallei) 		PF00724
(Oxidored_FMN) 		5 ALA A 183
LEU A 215
LEU A 234
LEU A 214
ARG A 262
 None
 1.46A 4x30A-3gkaA:
undetectable		 4x30A-3gkaA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzg PERMEASE
MOLYBDATE-BINDING
PERIPLASMIC PROTEIN

(Xanthomonas
citri) 		PF13531
(SBP_bac_11) 		5 ALA A 129
LEU A 109
LEU A 133
LEU A 115
ARG A 145
 None
 1.34A 4x30A-3gzgA:
undetectable		 4x30A-3gzgA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhr HUMAN GROWTH HORMONE

(Homo sapiens) 		PF00103
(Hormone_1) 		5 LEU A  23
LEU A 114
LEU A  20
ARG A  19
ARG A  16
 None
 1.30A 4x30A-3hhrA:
undetectable		 4x30A-3hhrA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksm ABC-TYPE SUGAR
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Hahella
chejuensis) 		PF13407
(Peripla_BP_4) 		5 ALA A 104
GLN A  61
LEU A  71
LEU A  45
LEU A  43
 None
 1.34A 4x30A-3ksmA:
undetectable		 4x30A-3ksmA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksx NITRATE TRANSPORT
PROTEIN

(Xanthomonas
citri) 		PF09084
(NMT1) 		5 ALA A 238
LEU A 268
LEU A  44
LEU A 242
ARG A 246
 None
 1.32A 4x30A-3ksxA:
undetectable		 4x30A-3ksxA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l19 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF13499
(EF-hand_7) 		5 ALA A 353
LEU A 480
LEU A 350
ASN A 346
LEU A 471
 None
 1.44A 4x30A-3l19A:
undetectable		 4x30A-3l19A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpx FYVE, RHOGEF AND PH
DOMAIN-CONTAINING
PROTEIN 5

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		5 ALA A 925
LEU A1003
LEU A1014
LEU A 942
ARG A 939
 None
 1.47A 4x30A-3mpxA:
undetectable		 4x30A-3mpxA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9n POSSIBLE
METHYLTRANSFERASE
(METHYLASE)

(Mycobacterium
tuberculosis) 		PF03602
(Cons_hypoth95) 		5 ALA A  61
LEU A 178
LEU A 117
LEU A  32
ARG A  29
 None
 1.27A 4x30A-3p9nA:
undetectable		 4x30A-3p9nA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		5 LEU A  60
LEU A 124
LEU A 120
ARG A 117
ARG A 121
 FAD  A 401 (-4.6A)
None
None
FAD  A 401 (-2.8A)
FAD  A 401 (-4.6A)
 1.09A 4x30A-3p9uA:
undetectable		 4x30A-3p9uA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvo NMRA FAMILY PROTEIN

(Shigella
flexneri) 		PF13460
(NAD_binding_10) 		5 ALA A  63
GLN A  82
LEU A  74
LEU A  60
LEU A   7
 None
 1.22A 4x30A-3qvoA:
undetectable		 4x30A-3qvoA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwk INULINASE

(Aspergillus
ficuum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 ALA X 503
GLN X 368
LEU X 382
LEU X 505
LEU X 496
 None
 1.44A 4x30A-3rwkX:
undetectable		 4x30A-3rwkX:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbj ACTIBIND

(Aspergillus
niger) 		PF00445
(Ribonuclease_T2) 		5 ALA A 232
GLN A  57
LEU A 173
LEU A  76
LEU A 169
 None
 1.49A 4x30A-3tbjA:
undetectable		 4x30A-3tbjA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v76 FLAVOPROTEIN

(Sinorhizobium
meliloti) 		PF03486
(HI0933_like) 		5 ALA A 216
GLN A 202
LEU A 198
LEU A 256
LEU A 236
 None
 1.43A 4x30A-3v76A:
undetectable		 4x30A-3v76A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v76 FLAVOPROTEIN

(Sinorhizobium
meliloti) 		PF03486
(HI0933_like) 		5 ALA A 240
GLN A 202
LEU A 198
LEU A 256
LEU A 236
 None
 1.30A 4x30A-3v76A:
undetectable		 4x30A-3v76A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5i FERROUS IRON
TRANSPORT PROTEIN B

(Gallionella
capsiferriformans) 		PF02421
(FeoB_N) 		5 ALA A  83
LEU A  38
LEU A  75
ASN A  78
LEU A  55
 None
 1.45A 4x30A-3w5iA:
undetectable		 4x30A-3w5iA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ab4 XENOBIOTIC REDUCTASE
B

(Pseudomonas
putida) 		PF00724
(Oxidored_FMN) 		5 ALA A 175
LEU A 207
LEU A 226
LEU A 206
ARG A 254
 None
 1.49A 4x30A-4ab4A:
undetectable		 4x30A-4ab4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4heh APPA PROTEIN

(Rhodobacter
sphaeroides) 		no annotation 5 ALA A 218
LEU A 198
LEU A 214
LEU A 195
ARG A 194
 None
 1.43A 4x30A-4hehA:
undetectable		 4x30A-4hehA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		5 ALA A 137
GLN A 354
LEU A 114
ASN A 116
ARG A 119
 None
 1.48A 4x30A-4je5A:
undetectable		 4x30A-4je5A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6j WINGS APART-LIKE
PROTEIN HOMOLOG

(Homo sapiens) 		PF07814
(WAPL) 		5 ALA A1032
LEU A 987
LEU A1002
ASN A 998
LEU A 988
 None
 1.45A 4x30A-4k6jA:
undetectable		 4x30A-4k6jA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea) 		PF00232
(Glyco_hydro_1) 		5 ALA A  70
LEU A 430
LEU A  65
LEU A 429
ARG A 456
 None
 1.44A 4x30A-4mdpA:
undetectable		 4x30A-4mdpA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mm0 P450-LIKE
MONOOXYGENASE

(Streptomyces
griseoviridis) 		PF00067
(p450) 		5 ALA A 117
LEU A 368
LEU A 121
LEU A 361
ARG A 260
 None
 1.45A 4x30A-4mm0A:
undetectable		 4x30A-4mm0A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		5 ALA A 238
LEU A 326
ASN A 246
LEU A 275
ARG A 365
 None
 1.14A 4x30A-4o5pA:
undetectable		 4x30A-4o5pA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio cholerae) 		PF13531
(SBP_bac_11) 		5 ALA A 150
LEU A 131
LEU A 154
LEU A 136
ARG A 166
 None
 1.17A 4x30A-4rxlA:
undetectable		 4x30A-4rxlA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmc OLD YELLOW ENZYME

(Kluyveromyces
marxianus) 		PF00724
(Oxidored_FMN) 		5 ALA A 327
LEU A 366
ASN A 367
LEU A 356
ARG A  60
 None
 1.49A 4x30A-4tmcA:
undetectable		 4x30A-4tmcA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v3q YIII_M4_AII

(synthetic
construct) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 ALA A  57
GLN A  68
LEU A  61
LEU A  28
ARG A  33
 None
 1.38A 4x30A-4v3qA:
undetectable		 4x30A-4v3qA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjm RIBOKINASE:CARBOHYDR
ATE KINASE, PFKB

(Brucella
abortus) 		PF00294
(PfkB) 		5 ALA A 122
GLN A 277
LEU A 273
LEU A 265
LEU A 270
 None
 1.37A 4x30A-4wjmA:
undetectable		 4x30A-4wjmA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT

(Caldanaerobacter
subterraneus) 		no annotation 5 ALA J 117
GLN J 141
LEU J 137
LEU J 121
LEU J 145
 None
 1.49A 4x30A-4ymwJ:
undetectable		 4x30A-4ymwJ:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5g FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		5 ALA A  82
LEU A 428
LEU A 421
LEU A 425
ARG A 427
 None
 1.12A 4x30A-5a5gA:
undetectable		 4x30A-5a5gA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex6 CYTOCHROME P450

(Streptomyces
toyocaensis) 		no annotation 5 ALA C 261
LEU C 280
LEU C 252
ASN C 255
LEU C 276
 None
 1.34A 4x30A-5ex6C:
undetectable		 4x30A-5ex6C:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fok IRON TRANSPORT OUTER
MEMBRANE RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ALA A  71
GLN A 115
LEU A 106
LEU A  68
LEU A 147
 None
 1.45A 4x30A-5fokA:
undetectable		 4x30A-5fokA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g5g PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT

(Escherichia
coli) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ALA C 111
LEU C 220
ASN C  95
LEU C 253
ARG C 249
 None
 1.45A 4x30A-5g5gC:
undetectable		 4x30A-5g5gC:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF

(Thermus
thermophilus) 		no annotation 5 ALA F 809
LEU F 885
LEU F 796
LEU F 881
ARG F 867
 None
 1.26A 4x30A-5it5F:
undetectable		 4x30A-5it5F:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgx PENTAERYTHRITOL
TETRANITRATE
REDUCTASE

(Enterobacter
cloacae) 		PF00724
(Oxidored_FMN) 		5 ALA A   2
LEU A 332
LEU A   5
ASN A  18
LEU A 336
 None
 1.38A 4x30A-5lgxA:
undetectable		 4x30A-5lgxA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC

(Flaveria
trinervia) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		5 ALA A 208
GLN A  76
LEU A  90
LEU A 205
LEU A  92
 None
 1.43A 4x30A-5lu4A:
undetectable		 4x30A-5lu4A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mil DUTPASE FAMILY
PROTEIN

(Staphylococcus
aureus) 		PF08761
(dUTPase_2) 		5 ALA A  79
GLN A   9
LEU A   5
LEU A  14
LEU A  10
 None
 1.42A 4x30A-5milA:
undetectable		 4x30A-5milA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap4 DNA POLYMERASE III
SUBUNIT BETA

(Acinetobacter
baumannii) 		no annotation 5 ALA A 287
LEU A 306
LEU A 283
LEU A 308
ARG A 285
 None
 1.37A 4x30A-6ap4A:
undetectable		 4x30A-6ap4A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en3 ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE
F2,MULTIFUNCTIONAL-A
UTOPROCESSING
REPEATS-IN-TOXIN

(Streptococcus
pyogenes;
Vibrio cholerae) 		no annotation 5 ALA A 466
LEU A 504
LEU A 487
LEU A 485
ARG A 486
 None
 1.29A 4x30A-6en3A:
undetectable		 4x30A-6en3A:
12.91