SIMILAR PATTERNS OF AMINO ACIDS FOR 4X20_D_LOCD502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3q PROTEIN (NUCLEAR
FACTOR KAPPA-B P52)

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		3 SER A 115
ALA A 121
VAL A 122
 None
 0.57A 4x20C-1a3qA:
undetectable		 4x20C-1a3qA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)

(Escherichia
coli) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain) 		3 SER B1739
ALA B1696
VAL B1695
 None
 0.61A 4x20C-1a9xB:
undetectable		 4x20C-1a9xB:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 SER A 259
ALA A 257
VAL A 256
 None
 0.63A 4x20C-1e8cA:
undetectable		 4x20C-1e8cA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eav MOLYBDOPTERIN
BIOSYNTHESIS CNX1
PROTEIN

(Arabidopsis
thaliana) 		PF00994
(MoCF_biosynth) 		3 SER A  26
ALA A  30
VAL A  33
 None
 0.67A 4x20C-1eavA:
2.5		 4x20C-1eavA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16) 		3 SER B 237
ALA B 355
VAL B 354
 None
 0.64A 4x20C-1ezvB:
undetectable		 4x20C-1ezvB:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3l PROTEIN ARGININE
METHYLTRANSFERASE
PRMT3

(Rattus
norvegicus) 		PF06325
(PrmA) 		3 SER A 368
ALA A 366
VAL A 365
 None
 0.62A 4x20C-1f3lA:
2.3		 4x20C-1f3lA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N) 		3 SER A  33
ALA A 166
VAL A 165
 None
 0.52A 4x20C-1fi4A:
undetectable		 4x20C-1fi4A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fna FIBRONECTIN
CELL-ADHESION MODULE
TYPE III-10

(Homo sapiens) 		PF00041
(fn3) 		3 SER A  17
ALA A  12
VAL A  11
 None
 0.64A 4x20C-1fnaA:
undetectable		 4x20C-1fnaA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		3 SER A  46
ALA A  29
VAL A  28
 None
 0.54A 4x20C-1gkeA:
undetectable		 4x20C-1gkeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvh FLAVOHEMOPROTEIN

(Escherichia
coli) 		PF00042
(Globin)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 SER A 169
ALA A 159
VAL A 158
 None
 0.61A 4x20C-1gvhA:
4.9		 4x20C-1gvhA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h54 MALTOSE
PHOSPHORYLASE

(Lactobacillus
brevis) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		3 SER A 123
ALA A 134
VAL A 133
 None
 0.67A 4x20C-1h54A:
2.3		 4x20C-1h54A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		3 SER A  14
ALA A  10
VAL A   9
 None
 0.65A 4x20C-1h7wA:
2.0		 4x20C-1h7wA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 SER A  33
ALA A  31
VAL A  30
 None
 0.61A 4x20C-1hr7A:
undetectable		 4x20C-1hr7A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2o TRANSALDOLASE B

(Escherichia
coli) 		PF00923
(TAL_FSA) 		3 SER A  94
ALA A  96
VAL A  97
 None
 0.65A 4x20C-1i2oA:
3.0		 4x20C-1i2oA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ijq LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		3 SER A 589
ALA A 591
VAL A 592
 None
 0.62A 4x20C-1ijqA:
undetectable		 4x20C-1ijqA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		3 SER A 171
ALA A 375
VAL A 376
 None
 0.59A 4x20C-1j1wA:
undetectable		 4x20C-1j1wA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jtd BETA-LACTAMASE
INHIBITOR PROTEIN II

(Streptomyces
exfoliatus) 		PF13540
(RCC1_2) 		3 SER B  64
ALA B  40
VAL B  39
 None
 0.60A 4x20C-1jtdB:
undetectable		 4x20C-1jtdB:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzu LIPOCALIN Q83

(Coturnix
coturnix) 		PF00061
(Lipocalin) 		3 SER A  50
ALA A  52
VAL A  53
 None
 0.65A 4x20C-1jzuA:
undetectable		 4x20C-1jzuA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1e DEOXY-D-MANNOSE-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE

(Haemophilus
influenzae) 		PF08282
(Hydrolase_3) 		3 SER A 121
ALA A 123
VAL A 124
 None
 0.38A 4x20C-1k1eA:
undetectable		 4x20C-1k1eA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka9 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00117
(GATase) 		3 SER H  28
ALA H  30
VAL H  31
 None
 0.62A 4x20C-1ka9H:
undetectable		 4x20C-1ka9H:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzq MAJOR SURFACE
ANTIGEN P30

(Toxoplasma
gondii) 		PF04092
(SAG) 		3 SER A 133
ALA A 140
VAL A 139
 None
 0.41A 4x20C-1kzqA:
undetectable		 4x20C-1kzqA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpo MALTOPORIN

(Escherichia
coli) 		PF02264
(LamB) 		3 SER A  67
ALA A  65
VAL A  64
 None
 0.66A 4x20C-1mpoA:
undetectable		 4x20C-1mpoA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8p CYSTATHIONINE
GAMMA-LYASE

(Saccharomyces
cerevisiae) 		PF01053
(Cys_Met_Meta_PP) 		3 SER A  94
ALA A  96
VAL A  97
 None
 0.63A 4x20C-1n8pA:
undetectable		 4x20C-1n8pA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnw HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		no annotation 3 SER A 194
ALA A 174
VAL A 173
 None
 0.48A 4x20C-1nnwA:
undetectable		 4x20C-1nnwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK

(Escherichia
coli) 		PF02615
(Ldh_2) 		3 SER A 260
ALA A 110
VAL A 109
 None
 0.46A 4x20C-1nxuA:
undetectable		 4x20C-1nxuA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o3t CATABOLITE GENE
ACTIVATOR PROTEIN

(Escherichia
coli) 		PF00027
(cNMP_binding)
PF00325
(Crp) 		3 SER A  46
ALA A  48
VAL A  49
 None
None
CMP  A 762 (-4.5A)
 0.59A 4x20C-1o3tA:
undetectable		 4x20C-1o3tA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oaa SEPIAPTERIN
REDUCTASE

(Mus musculus) 		PF00106
(adh_short) 		3 SER A  33
ALA A   9
VAL A  10
 None
 0.56A 4x20C-1oaaA:
7.4		 4x20C-1oaaA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		3 SER A 239
ALA A 215
VAL A 214
 None
 0.60A 4x20C-1oznA:
undetectable		 4x20C-1oznA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyt CHYMOTRYPSINOGEN C

(Bos taurus) 		PF00089
(Trypsin) 		3 SER D 780
ALA D 767
VAL D 766
 None
 0.59A 4x20C-1pytD:
undetectable		 4x20C-1pytD:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9h CELLOBIOHYDROLASE I
CATALYTIC DOMAIN

(Rasamsonia
emersonii) 		PF00840
(Glyco_hydro_7) 		3 SER A 219
ALA A 221
VAL A 222
 None
 0.58A 4x20C-1q9hA:
undetectable		 4x20C-1q9hA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qox BETA-GLUCOSIDASE

(Bacillus
circulans) 		PF00232
(Glyco_hydro_1) 		3 SER A 224
ALA A 226
VAL A 227
 None
 0.64A 4x20C-1qoxA:
1.2		 4x20C-1qoxA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spj KALLIKREIN 1

(Homo sapiens) 		PF00089
(Trypsin) 		3 SER A 226
ALA A 228
VAL A 229
 None
 0.59A 4x20C-1spjA:
undetectable		 4x20C-1spjA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE

(Geobacillus
stearothermophilus) 		PF02578
(Cu-oxidase_4) 		3 SER A 239
ALA A 174
VAL A 173
 None
 0.60A 4x20C-1t8hA:
undetectable		 4x20C-1t8hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE

(Escherichia
coli) 		PF00291
(PALP)
PF00585
(Thr_dehydrat_C) 		3 SER A 315
ALA A 285
VAL A 284
 PLP  A 962 (-3.1A)
None
None
 0.56A 4x20C-1tdjA:
2.3		 4x20C-1tdjA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 SER B 396
ALA B 398
VAL B 399
 None
 0.66A 4x20C-1tqyB:
undetectable		 4x20C-1tqyB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujx POLYNUCLEOTIDE
KINASE
3'-PHOSPHATASE

(Mus musculus) 		no annotation 3 SER A  91
ALA A  70
VAL A  69
 None
 0.56A 4x20C-1ujxA:
undetectable		 4x20C-1ujxA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9l GLUTAMATE
DEHYDROGENASE

(Pyrobaculum
islandicum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 SER A 240
ALA A 214
VAL A 213
 NAD  A 430 ( 4.0A)
None
None
 0.65A 4x20C-1v9lA:
undetectable		 4x20C-1v9lA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE

(Aeropyrum
pernix) 		PF00793
(DAHP_synth_1) 		3 SER A  38
ALA A  40
VAL A  41
 None
 0.66A 4x20C-1vs1A:
undetectable		 4x20C-1vs1A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC

(Homo sapiens) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		3 SER A  11
ALA A  75
VAL A  74
 NAD  A3001 (-4.0A)
None
None
 0.66A 4x20C-1wpqA:
4.0		 4x20C-1wpqA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 SER A 182
ALA A 241
VAL A 240
 SER  A 182 ( 0.0A)
ALA  A 241 ( 0.0A)
VAL  A 240 ( 0.6A)
 0.51A 4x20C-1wqaA:
undetectable		 4x20C-1wqaA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wv8 HYPOTHETICAL PROTEIN
TTHA1013

(Thermus
thermophilus) 		PF08972
(DUF1902) 		3 SER A  21
ALA A  19
VAL A  18
 None
 0.64A 4x20C-1wv8A:
undetectable		 4x20C-1wv8A:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxd SHIKIMATE
5-DEHYDROGENASE

(Thermus
thermophilus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		3 SER A  32
ALA A   5
VAL A   6
 None
 0.57A 4x20C-1wxdA:
2.4		 4x20C-1wxdA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xks NUCLEAR PORE COMPLEX
PROTEIN NUP133

(Homo sapiens) 		no annotation 3 SER A 162
ALA A 172
VAL A 173
 None
 0.62A 4x20C-1xksA:
undetectable		 4x20C-1xksA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xww LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE

(Homo sapiens) 		PF01451
(LMWPc) 		3 SER A  43
ALA A  45
VAL A  46
 None
 0.38A 4x20C-1xwwA:
2.9		 4x20C-1xwwA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y30 HYPOTHETICAL PROTEIN
RV1155

(Mycobacterium
tuberculosis) 		PF01243
(Putative_PNPOx) 		3 SER A 137
ALA A  82
VAL A  81
 None
 0.61A 4x20C-1y30A:
undetectable		 4x20C-1y30A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yax VIRULENCE SENSOR
PROTEIN PHOQ, SENSOR
DOMAIN

(Salmonella
enterica) 		PF08918
(PhoQ_Sensor) 		3 SER A 158
ALA A 160
VAL A 161
 None
 0.65A 4x20C-1yaxA:
undetectable		 4x20C-1yaxA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygh PROTEIN
(TRANSCRIPTIONAL
ACTIVATOR GCN5)

(Saccharomyces
cerevisiae) 		PF00583
(Acetyltransf_1) 		3 SER A 147
ALA A 149
VAL A 150
 None
 0.67A 4x20C-1yghA:
undetectable		 4x20C-1yghA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjm POLYNUCLEOTIDE
5'-HYDROXYL-KINASE

(Mus musculus) 		no annotation 3 SER A  84
ALA A  63
VAL A  62
 None
 0.55A 4x20C-1yjmA:
undetectable		 4x20C-1yjmA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YIAJ

(Escherichia
coli) 		PF01614
(IclR) 		3 SER A 147
ALA A 145
VAL A 135
 PO4  A 301 (-2.8A)
None
None
 0.65A 4x20C-1ysqA:
undetectable		 4x20C-1ysqA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zeq CATION EFFLUX SYSTEM
PROTEIN CUSF

(Escherichia
coli) 		PF11604
(CusF_Ec) 		3 SER X  17
ALA X  69
VAL X  68
 None
 0.51A 4x20C-1zeqX:
undetectable		 4x20C-1zeqX:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjj HYPOTHETICAL PROTEIN
PH1952

(Pyrococcus
horikoshii) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		3 SER A 169
ALA A 173
VAL A 176
 None
 0.65A 4x20C-1zjjA:
undetectable		 4x20C-1zjjA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2d N-ACETYLGALACTOSAMIN
E KINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		3 SER A 219
ALA A 221
VAL A 222
 None
 0.65A 4x20C-2a2dA:
undetectable		 4x20C-2a2dA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adv GLUTARYL 7-
AMINOCEPHALOSPORANIC
ACID ACYLASE

(Pseudomonas sp.
SY-77-1) 		PF01804
(Penicil_amidase) 		3 SER C 122
ALA C 138
VAL C 137
 None
 0.65A 4x20C-2advC:
undetectable		 4x20C-2advC:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aj4 GALACTOKINASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		3 SER A 523
ALA A  48
VAL A  47
 None
 0.53A 4x20C-2aj4A:
undetectable		 4x20C-2aj4A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b30 PVIVAX HYPOTHETICAL
PROTEIN

(Plasmodium
vivax) 		PF08282
(Hydrolase_3) 		3 SER A 262
ALA A 264
VAL A 265
 None
 0.40A 4x20C-2b30A:
3.9		 4x20C-2b30A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btj GREEN TO RED
PHOTOCONVERTIBLE
GPF-LIKE PROTEIN
EOSFP

(Lobophyllia
hemprichii) 		PF01353
(GFP) 		3 SER A 218
ALA A 216
VAL A 215
 None
 0.58A 4x20C-2btjA:
undetectable		 4x20C-2btjA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Sulfolobus
solfataricus) 		PF00218
(IGPS) 		3 SER A 181
ALA A 209
VAL A 208
 None
 0.40A 4x20C-2c3zA:
undetectable		 4x20C-2c3zA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbm NEOCARZINOSTATIN

(Streptomyces
carzinostaticus) 		PF00960
(Neocarzinostat) 		3 SER A  62
ALA A  22
VAL A  21
 None
 0.60A 4x20C-2cbmA:
undetectable		 4x20C-2cbmA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy7 CYSTEINE PROTEASE
APG4B

(Homo sapiens) 		PF03416
(Peptidase_C54) 		3 SER A 316
ALA A 318
VAL A 319
 None
 0.54A 4x20C-2cy7A:
undetectable		 4x20C-2cy7A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhz RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR (GEF)-LIKE 1

(Homo sapiens) 		no annotation 3 SER A  62
ALA A  60
VAL A  59
 None
 0.60A 4x20C-2dhzA:
undetectable		 4x20C-2dhzA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 SER A  47
ALA A  45
VAL A  44
 None
 0.51A 4x20C-2e5vA:
undetectable		 4x20C-2e5vA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG

(Mus musculus) 		PF01612
(DNA_pol_A_exo1) 		3 SER A 110
ALA A  92
VAL A  91
 None
 0.40A 4x20C-2e6mA:
undetectable		 4x20C-2e6mA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekx CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF00017
(SH2) 		3 SER A  53
ALA A  55
VAL A  56
 None
 0.53A 4x20C-2ekxA:
undetectable		 4x20C-2ekxA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 SER A 304
ALA A 307
VAL A 308
 None
 0.66A 4x20C-2ep5A:
3.1		 4x20C-2ep5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbv WERNER SYNDROME
HELICASE

(Homo sapiens) 		PF01612
(DNA_pol_A_exo1) 		3 SER A 116
ALA A  98
VAL A  97
 None
 0.49A 4x20C-2fbvA:
undetectable		 4x20C-2fbvA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fdr CONSERVED
HYPOTHETICAL PROTEIN

(Agrobacterium
fabrum) 		PF13419
(HAD_2) 		3 SER A  18
ALA A  22
VAL A  25
 None
 0.62A 4x20C-2fdrA:
3.9		 4x20C-2fdrA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frg TREM-LIKE
TRANSCRIPT-1

(Homo sapiens) 		no annotation 3 SER P  64
ALA P  66
VAL P  67
 None
 0.38A 4x20C-2frgP:
undetectable		 4x20C-2frgP:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuk XC6422 PROTEIN

(Xanthomonas
campestris) 		PF12146
(Hydrolase_4) 		3 SER A  10
ALA A  25
VAL A  24
 None
 0.55A 4x20C-2fukA:
undetectable		 4x20C-2fukA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjn HYPOTHETICAL PROTEIN
PA1024

(Pseudomonas
aeruginosa) 		PF03060
(NMO) 		3 SER A 227
ALA A 242
VAL A 241
 None
 0.58A 4x20C-2gjnA:
undetectable		 4x20C-2gjnA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gju 252AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		no annotation 3 SER A 194
ALA A 174
VAL A 173
 None
 0.50A 4x20C-2gjuA:
undetectable		 4x20C-2gjuA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gnw NON-SYMBIOTIC
HEMOGLOBIN 1

(Oryza sativa) 		PF00042
(Globin) 		3 SER A  12
ALA A  10
VAL A   9
 None
 0.63A 4x20C-2gnwA:
undetectable		 4x20C-2gnwA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw3 KAEDE

(Trachyphyllia
geoffroyi) 		PF01353
(GFP) 		3 SER A 218
ALA A 216
VAL A 215
 None
 0.58A 4x20C-2gw3A:
undetectable		 4x20C-2gw3A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw4 KAEDE

(Trachyphyllia
geoffroyi) 		PF01353
(GFP) 		3 SER B 218
ALA B 216
VAL B 215
 None
 0.58A 4x20C-2gw4B:
undetectable		 4x20C-2gw4B:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6v GENERAL SECRETION
PATHWAY PROTEIN C

(Vibrio cholerae) 		no annotation 3 SER A 289
ALA A 263
VAL A 262
 None
 0.64A 4x20C-2i6vA:
undetectable		 4x20C-2i6vA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iks DNA-BINDING
TRANSCRIPTIONAL DUAL
REGULATOR

(Escherichia
coli) 		PF00532
(Peripla_BP_1) 		3 SER A 124
ALA A 146
VAL A 145
 None
 0.57A 4x20C-2iksA:
undetectable		 4x20C-2iksA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k9u FILAMIN-BINDING LIM
PROTEIN 1

(Homo sapiens) 		no annotation 3 SER B  12
ALA B  10
VAL B   9
 None
 0.66A 4x20C-2k9uB:
undetectable		 4x20C-2k9uB:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2khc TESTIS-SPECIFIC
RNP-TYPE RNA BINDING
PROTEIN

(Drosophila
melanogaster) 		PF00076
(RRM_1) 		3 SER A 503
ALA A 501
VAL A 500
 None
 0.54A 4x20C-2khcA:
undetectable		 4x20C-2khcA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkz RNA-BINDING PROTEIN
5

(Homo sapiens) 		PF00076
(RRM_1) 		3 SER A  35
ALA A  37
VAL A  38
 None
 0.65A 4x20C-2lkzA:
undetectable		 4x20C-2lkzA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mfi 30S RIBOSOMAL
PROTEIN S1

(Escherichia
coli) 		PF00575
(S1) 		3 SER A  22
ALA A  71
VAL A  70
 None
 0.37A 4x20C-2mfiA:
undetectable		 4x20C-2mfiA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n51 ELONGATION FACTOR
1-DELTA

(Homo sapiens) 		PF00736
(EF1_GNE)
PF10587
(EF-1_beta_acid) 		3 SER A 196
ALA A 194
VAL A 193
 None
 0.55A 4x20C-2n51A:
undetectable		 4x20C-2n51A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n7y COPPER-TRANSPORTING
ATPASE 2

(Homo sapiens) 		PF00403
(HMA) 		3 SER A   9
ALA A   7
VAL A   6
 None
 0.64A 4x20C-2n7yA:
undetectable		 4x20C-2n7yA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn6 EXOSOME COMPLEX
EXONUCLEASE RRP43

(Homo sapiens) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		3 SER C 197
ALA C 195
VAL C 194
 None
 0.66A 4x20C-2nn6C:
undetectable		 4x20C-2nn6C:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oo4 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 2

(Homo sapiens) 		PF00066
(Notch)
PF06816
(NOD)
PF07684
(NODP) 		3 SER A1621
ALA A1619
VAL A1618
 None
 0.56A 4x20C-2oo4A:
undetectable		 4x20C-2oo4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4u ACID PHOSPHATASE 1

(Mus musculus) 		PF01451
(LMWPc) 		3 SER A  44
ALA A  46
VAL A  47
 None
 0.39A 4x20C-2p4uA:
undetectable		 4x20C-2p4uA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6p GLYCOSYL TRANSFERASE

(Streptomyces
fradiae) 		PF06722
(DUF1205) 		3 SER A 195
ALA A 193
VAL A 192
 None
 0.32A 4x20C-2p6pA:
4.9		 4x20C-2p6pA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF16073
(SAT) 		3 SER B 295
ALA B 299
VAL B 302
 None
 0.66A 4x20C-2pffB:
undetectable		 4x20C-2pffB:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpt EH DOMAIN-CONTAINING
PROTEIN-2

(Mus musculus) 		PF00350
(Dynamin_N)
PF12763
(EF-hand_4)
PF16880
(EHD_N) 		3 SER A 150
ALA A  99
VAL A  98
 None
 0.65A 4x20C-2qptA:
undetectable		 4x20C-2qptA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v24 SPRY
DOMAIN-CONTAINING
SOCS BOX PROTEIN 4

(Homo sapiens) 		PF00622
(SPRY) 		3 SER A 147
ALA A 160
VAL A 159
 None
 0.64A 4x20C-2v24A:
undetectable		 4x20C-2v24A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1v NITRILASE HOMOLOG 2

(Mus musculus) 		PF00795
(CN_hydrolase) 		3 SER A 260
ALA A 242
VAL A 241
 None
 0.48A 4x20C-2w1vA:
undetectable		 4x20C-2w1vA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG

(Escherichia
coli) 		PF13483
(Lactamase_B_3) 		3 SER A 224
ALA A 245
VAL A 244
 None
 0.43A 4x20C-2wymA:
undetectable		 4x20C-2wymA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Heterobasidion
annosum) 		PF00840
(Glyco_hydro_7) 		3 SER A 224
ALA A 226
VAL A 227
 None
 0.51A 4x20C-2yg1A:
undetectable		 4x20C-2yg1A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygl BLOOD GROUP A-AND
B-CLEAVING
ENDO-BETA-GALACTOSID
ASE

(Streptococcus
pneumoniae) 		PF08305
(NPCBM) 		3 SER A 126
ALA A 124
VAL A 123
 None
 0.58A 4x20C-2yglA:
undetectable		 4x20C-2yglA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yha POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa) 		PF02171
(Piwi) 		3 SER A 934
ALA A 699
VAL A 687
 None
 0.62A 4x20C-2yhaA:
undetectable		 4x20C-2yhaA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhb POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa) 		PF02171
(Piwi) 		3 SER A 934
ALA A 699
VAL A 687
 None
 0.59A 4x20C-2yhbA:
undetectable		 4x20C-2yhbA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yux MYOSIN-BINDING
PROTEIN C, SLOW-TYPE

(Homo sapiens) 		PF00041
(fn3) 		3 SER A  75
ALA A  35
VAL A  34
 None
 0.54A 4x20C-2yuxA:
undetectable		 4x20C-2yuxA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpa UNCHARACTERIZED
PROTEIN YPFI

(Escherichia
coli) 		PF05127
(Helicase_RecD)
PF08351
(DUF1726)
PF13718
(GNAT_acetyltr_2)
PF17176
(tRNA_bind_3) 		3 SER A 100
ALA A  76
VAL A  77
 None
 0.61A 4x20C-2zpaA:
undetectable		 4x20C-2zpaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsc TAMAVIDIN2

(Pleurotus
cornucopiae) 		PF01382
(Avidin) 		3 SER A  81
ALA A  62
VAL A  61
 None
None
GOL  A1810 (-4.5A)
 0.61A 4x20C-2zscA:
undetectable		 4x20C-2zscA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akc CYTIDYLATE KINASE

(Thermus
thermophilus) 		PF02224
(Cytidylate_kin) 		3 SER A  33
ALA A 123
VAL A 122
 CDP  A 209 (-3.1A)
None
None
 0.64A 4x20C-3akcA:
undetectable		 4x20C-3akcA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoh ANTI-CLEAVAGE
ANTI-GREA
TRANSCRIPTION FACTOR
GFH1

(Thermus
thermophilus) 		PF01272
(GreA_GreB)
PF03449
(GreA_GreB_N) 		3 SER X  70
ALA X  72
VAL X  73
 None
 0.66A 4x20C-3aohX:
undetectable		 4x20C-3aohX:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE

(Homo sapiens) 		PF00198
(2-oxoacid_dh) 		3 SER A 430
ALA A 428
VAL A 427
 None
 0.52A 4x20C-3b8kA:
undetectable		 4x20C-3b8kA:
19.78