SIMILAR PATTERNS OF AMINO ACIDS FOR 4X20_D_LOCD502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3q PROTEIN (NUCLEAR
FACTOR KAPPA-B P52)

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		3 SER A 115
ALA A 121
VAL A 122
 None
 0.57A 4x20C-1a3qA:
undetectable		 4x20C-1a3qA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)

(Escherichia
coli) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain) 		3 SER B1739
ALA B1696
VAL B1695
 None
 0.61A 4x20C-1a9xB:
undetectable		 4x20C-1a9xB:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 SER A 259
ALA A 257
VAL A 256
 None
 0.63A 4x20C-1e8cA:
undetectable		 4x20C-1e8cA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eav MOLYBDOPTERIN
BIOSYNTHESIS CNX1
PROTEIN

(Arabidopsis
thaliana) 		PF00994
(MoCF_biosynth) 		3 SER A  26
ALA A  30
VAL A  33
 None
 0.67A 4x20C-1eavA:
2.5		 4x20C-1eavA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16) 		3 SER B 237
ALA B 355
VAL B 354
 None
 0.64A 4x20C-1ezvB:
undetectable		 4x20C-1ezvB:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3l PROTEIN ARGININE
METHYLTRANSFERASE
PRMT3

(Rattus
norvegicus) 		PF06325
(PrmA) 		3 SER A 368
ALA A 366
VAL A 365
 None
 0.62A 4x20C-1f3lA:
2.3		 4x20C-1f3lA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N) 		3 SER A  33
ALA A 166
VAL A 165
 None
 0.52A 4x20C-1fi4A:
undetectable		 4x20C-1fi4A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fna FIBRONECTIN
CELL-ADHESION MODULE
TYPE III-10

(Homo sapiens) 		PF00041
(fn3) 		3 SER A  17
ALA A  12
VAL A  11
 None
 0.64A 4x20C-1fnaA:
undetectable		 4x20C-1fnaA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		3 SER A  46
ALA A  29
VAL A  28
 None
 0.54A 4x20C-1gkeA:
undetectable		 4x20C-1gkeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvh FLAVOHEMOPROTEIN

(Escherichia
coli) 		PF00042
(Globin)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 SER A 169
ALA A 159
VAL A 158
 None
 0.61A 4x20C-1gvhA:
4.9		 4x20C-1gvhA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h54 MALTOSE
PHOSPHORYLASE

(Lactobacillus
brevis) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		3 SER A 123
ALA A 134
VAL A 133
 None
 0.67A 4x20C-1h54A:
2.3		 4x20C-1h54A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7w DIHYDROPYRIMIDINE
DEHYDROGENASE

(Sus scrofa) 		PF01180
(DHO_dh)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
PF14697
(Fer4_21) 		3 SER A  14
ALA A  10
VAL A   9
 None
 0.65A 4x20C-1h7wA:
2.0		 4x20C-1h7wA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		3 SER A  33
ALA A  31
VAL A  30
 None
 0.61A 4x20C-1hr7A:
undetectable		 4x20C-1hr7A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2o TRANSALDOLASE B

(Escherichia
coli) 		PF00923
(TAL_FSA) 		3 SER A  94
ALA A  96
VAL A  97
 None
 0.65A 4x20C-1i2oA:
3.0		 4x20C-1i2oA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ijq LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		3 SER A 589
ALA A 591
VAL A 592
 None
 0.62A 4x20C-1ijqA:
undetectable		 4x20C-1ijqA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1w ISOCITRATE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF03971
(IDH) 		3 SER A 171
ALA A 375
VAL A 376
 None
 0.59A 4x20C-1j1wA:
undetectable		 4x20C-1j1wA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jtd BETA-LACTAMASE
INHIBITOR PROTEIN II

(Streptomyces
exfoliatus) 		PF13540
(RCC1_2) 		3 SER B  64
ALA B  40
VAL B  39
 None
 0.60A 4x20C-1jtdB:
undetectable		 4x20C-1jtdB:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzu LIPOCALIN Q83

(Coturnix
coturnix) 		PF00061
(Lipocalin) 		3 SER A  50
ALA A  52
VAL A  53
 None
 0.65A 4x20C-1jzuA:
undetectable		 4x20C-1jzuA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1e DEOXY-D-MANNOSE-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE

(Haemophilus
influenzae) 		PF08282
(Hydrolase_3) 		3 SER A 121
ALA A 123
VAL A 124
 None
 0.38A 4x20C-1k1eA:
undetectable		 4x20C-1k1eA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka9 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00117
(GATase) 		3 SER H  28
ALA H  30
VAL H  31
 None
 0.62A 4x20C-1ka9H:
undetectable		 4x20C-1ka9H:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kzq MAJOR SURFACE
ANTIGEN P30

(Toxoplasma
gondii) 		PF04092
(SAG) 		3 SER A 133
ALA A 140
VAL A 139
 None
 0.41A 4x20C-1kzqA:
undetectable		 4x20C-1kzqA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpo MALTOPORIN

(Escherichia
coli) 		PF02264
(LamB) 		3 SER A  67
ALA A  65
VAL A  64
 None
 0.66A 4x20C-1mpoA:
undetectable		 4x20C-1mpoA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8p CYSTATHIONINE
GAMMA-LYASE

(Saccharomyces
cerevisiae) 		PF01053
(Cys_Met_Meta_PP) 		3 SER A  94
ALA A  96
VAL A  97
 None
 0.63A 4x20C-1n8pA:
undetectable		 4x20C-1n8pA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnw HYPOTHETICAL PROTEIN

(Pyrococcus
furiosus) 		no annotation 3 SER A 194
ALA A 174
VAL A 173
 None
 0.48A 4x20C-1nnwA:
undetectable		 4x20C-1nnwA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxu HYPOTHETICAL
OXIDOREDUCTASE YIAK

(Escherichia
coli) 		PF02615
(Ldh_2) 		3 SER A 260
ALA A 110
VAL A 109
 None
 0.46A 4x20C-1nxuA:
undetectable		 4x20C-1nxuA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o3t CATABOLITE GENE
ACTIVATOR PROTEIN

(Escherichia
coli) 		PF00027
(cNMP_binding)
PF00325
(Crp) 		3 SER A  46
ALA A  48
VAL A  49
 None
None
CMP  A 762 (-4.5A)
 0.59A 4x20C-1o3tA:
undetectable		 4x20C-1o3tA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oaa SEPIAPTERIN
REDUCTASE

(Mus musculus) 		PF00106
(adh_short) 		3 SER A  33
ALA A   9
VAL A  10
 None
 0.56A 4x20C-1oaaA:
7.4		 4x20C-1oaaA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozn RETICULON 4 RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8) 		3 SER A 239
ALA A 215
VAL A 214
 None
 0.60A 4x20C-1oznA:
undetectable		 4x20C-1oznA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyt CHYMOTRYPSINOGEN C

(Bos taurus) 		PF00089
(Trypsin) 		3 SER D 780
ALA D 767
VAL D 766
 None
 0.59A 4x20C-1pytD:
undetectable		 4x20C-1pytD:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9h CELLOBIOHYDROLASE I
CATALYTIC DOMAIN

(Rasamsonia
emersonii) 		PF00840
(Glyco_hydro_7) 		3 SER A 219
ALA A 221
VAL A 222
 None
 0.58A 4x20C-1q9hA:
undetectable		 4x20C-1q9hA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qox BETA-GLUCOSIDASE

(Bacillus
circulans) 		PF00232
(Glyco_hydro_1) 		3 SER A 224
ALA A 226
VAL A 227
 None
 0.64A 4x20C-1qoxA:
1.2		 4x20C-1qoxA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spj KALLIKREIN 1

(Homo sapiens) 		PF00089
(Trypsin) 		3 SER A 226
ALA A 228
VAL A 229
 None
 0.59A 4x20C-1spjA:
undetectable		 4x20C-1spjA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE

(Geobacillus
stearothermophilus) 		PF02578
(Cu-oxidase_4) 		3 SER A 239
ALA A 174
VAL A 173
 None
 0.60A 4x20C-1t8hA:
undetectable		 4x20C-1t8hA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE

(Escherichia
coli) 		PF00291
(PALP)
PF00585
(Thr_dehydrat_C) 		3 SER A 315
ALA A 285
VAL A 284
 PLP  A 962 (-3.1A)
None
None
 0.56A 4x20C-1tdjA:
2.3		 4x20C-1tdjA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		3 SER B 396
ALA B 398
VAL B 399
 None
 0.66A 4x20C-1tqyB:
undetectable		 4x20C-1tqyB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ujx POLYNUCLEOTIDE
KINASE
3'-PHOSPHATASE

(Mus musculus) 		no annotation 3 SER A  91
ALA A  70
VAL A  69
 None
 0.56A 4x20C-1ujxA:
undetectable		 4x20C-1ujxA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9l GLUTAMATE
DEHYDROGENASE

(Pyrobaculum
islandicum) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 SER A 240
ALA A 214
VAL A 213
 NAD  A 430 ( 4.0A)
None
None
 0.65A 4x20C-1v9lA:
undetectable		 4x20C-1v9lA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE

(Aeropyrum
pernix) 		PF00793
(DAHP_synth_1) 		3 SER A  38
ALA A  40
VAL A  41
 None
 0.66A 4x20C-1vs1A:
undetectable		 4x20C-1vs1A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpq GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD+], CYTOPLASMIC

(Homo sapiens) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		3 SER A  11
ALA A  75
VAL A  74
 NAD  A3001 (-4.0A)
None
None
 0.66A 4x20C-1wpqA:
4.0		 4x20C-1wpqA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		3 SER A 182
ALA A 241
VAL A 240
 SER  A 182 ( 0.0A)
ALA  A 241 ( 0.0A)
VAL  A 240 ( 0.6A)
 0.51A 4x20C-1wqaA:
undetectable		 4x20C-1wqaA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wv8 HYPOTHETICAL PROTEIN
TTHA1013

(Thermus
thermophilus) 		PF08972
(DUF1902) 		3 SER A  21
ALA A  19
VAL A  18
 None
 0.64A 4x20C-1wv8A:
undetectable		 4x20C-1wv8A:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxd SHIKIMATE
5-DEHYDROGENASE

(Thermus
thermophilus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		3 SER A  32
ALA A   5
VAL A   6
 None
 0.57A 4x20C-1wxdA:
2.4		 4x20C-1wxdA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xks NUCLEAR PORE COMPLEX
PROTEIN NUP133

(Homo sapiens) 		no annotation 3 SER A 162
ALA A 172
VAL A 173
 None
 0.62A 4x20C-1xksA:
undetectable		 4x20C-1xksA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xww LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE

(Homo sapiens) 		PF01451
(LMWPc) 		3 SER A  43
ALA A  45
VAL A  46
 None
 0.38A 4x20C-1xwwA:
2.9		 4x20C-1xwwA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y30 HYPOTHETICAL PROTEIN
RV1155

(Mycobacterium
tuberculosis) 		PF01243
(Putative_PNPOx) 		3 SER A 137
ALA A  82
VAL A  81
 None
 0.61A 4x20C-1y30A:
undetectable		 4x20C-1y30A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yax VIRULENCE SENSOR
PROTEIN PHOQ, SENSOR
DOMAIN

(Salmonella
enterica) 		PF08918
(PhoQ_Sensor) 		3 SER A 158
ALA A 160
VAL A 161
 None
 0.65A 4x20C-1yaxA:
undetectable		 4x20C-1yaxA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygh PROTEIN
(TRANSCRIPTIONAL
ACTIVATOR GCN5)

(Saccharomyces
cerevisiae) 		PF00583
(Acetyltransf_1) 		3 SER A 147
ALA A 149
VAL A 150
 None
 0.67A 4x20C-1yghA:
undetectable		 4x20C-1yghA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjm POLYNUCLEOTIDE
5'-HYDROXYL-KINASE

(Mus musculus) 		no annotation 3 SER A  84
ALA A  63
VAL A  62
 None
 0.55A 4x20C-1yjmA:
undetectable		 4x20C-1yjmA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR YIAJ

(Escherichia
coli) 		PF01614
(IclR) 		3 SER A 147
ALA A 145
VAL A 135
 PO4  A 301 (-2.8A)
None
None
 0.65A 4x20C-1ysqA:
undetectable		 4x20C-1ysqA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zeq CATION EFFLUX SYSTEM
PROTEIN CUSF

(Escherichia
coli) 		PF11604
(CusF_Ec) 		3 SER X  17
ALA X  69
VAL X  68
 None
 0.51A 4x20C-1zeqX:
undetectable		 4x20C-1zeqX:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjj HYPOTHETICAL PROTEIN
PH1952

(Pyrococcus
horikoshii) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		3 SER A 169
ALA A 173
VAL A 176
 None
 0.65A 4x20C-1zjjA:
undetectable		 4x20C-1zjjA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2d N-ACETYLGALACTOSAMIN
E KINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		3 SER A 219
ALA A 221
VAL A 222
 None
 0.65A 4x20C-2a2dA:
undetectable		 4x20C-2a2dA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adv GLUTARYL 7-
AMINOCEPHALOSPORANIC
ACID ACYLASE

(Pseudomonas sp.
SY-77-1) 		PF01804
(Penicil_amidase) 		3 SER C 122
ALA C 138
VAL C 137
 None
 0.65A 4x20C-2advC:
undetectable		 4x20C-2advC:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aj4 GALACTOKINASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		3 SER A 523
ALA A  48
VAL A  47
 None
 0.53A 4x20C-2aj4A:
undetectable		 4x20C-2aj4A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b30 PVIVAX HYPOTHETICAL
PROTEIN

(Plasmodium
vivax) 		PF08282
(Hydrolase_3) 		3 SER A 262
ALA A 264
VAL A 265
 None
 0.40A 4x20C-2b30A:
3.9		 4x20C-2b30A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btj GREEN TO RED
PHOTOCONVERTIBLE
GPF-LIKE PROTEIN
EOSFP

(Lobophyllia
hemprichii) 		PF01353
(GFP) 		3 SER A 218
ALA A 216
VAL A 215
 None
 0.58A 4x20C-2btjA:
undetectable		 4x20C-2btjA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Sulfolobus
solfataricus) 		PF00218
(IGPS) 		3 SER A 181
ALA A 209
VAL A 208
 None
 0.40A 4x20C-2c3zA:
undetectable		 4x20C-2c3zA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbm NEOCARZINOSTATIN

(Streptomyces
carzinostaticus) 		PF00960
(Neocarzinostat) 		3 SER A  62
ALA A  22
VAL A  21
 None
 0.60A 4x20C-2cbmA:
undetectable		 4x20C-2cbmA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cy7 CYSTEINE PROTEASE
APG4B

(Homo sapiens) 		PF03416
(Peptidase_C54) 		3 SER A 316
ALA A 318
VAL A 319
 None
 0.54A 4x20C-2cy7A:
undetectable		 4x20C-2cy7A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhz RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR (GEF)-LIKE 1

(Homo sapiens) 		no annotation 3 SER A  62
ALA A  60
VAL A  59
 None
 0.60A 4x20C-2dhzA:
undetectable		 4x20C-2dhzA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		3 SER A  47
ALA A  45
VAL A  44
 None
 0.51A 4x20C-2e5vA:
undetectable		 4x20C-2e5vA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6m WERNER SYNDROME
ATP-DEPENDENT
HELICASE HOMOLOG

(Mus musculus) 		PF01612
(DNA_pol_A_exo1) 		3 SER A 110
ALA A  92
VAL A  91
 None
 0.40A 4x20C-2e6mA:
undetectable		 4x20C-2e6mA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekx CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF00017
(SH2) 		3 SER A  53
ALA A  55
VAL A  56
 None
 0.53A 4x20C-2ekxA:
undetectable		 4x20C-2ekxA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 SER A 304
ALA A 307
VAL A 308
 None
 0.66A 4x20C-2ep5A:
3.1		 4x20C-2ep5A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbv WERNER SYNDROME
HELICASE

(Homo sapiens) 		PF01612
(DNA_pol_A_exo1) 		3 SER A 116
ALA A  98
VAL A  97
 None
 0.49A 4x20C-2fbvA:
undetectable		 4x20C-2fbvA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fdr CONSERVED
HYPOTHETICAL PROTEIN

(Agrobacterium
fabrum) 		PF13419
(HAD_2) 		3 SER A  18
ALA A  22
VAL A  25
 None
 0.62A 4x20C-2fdrA:
3.9		 4x20C-2fdrA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frg TREM-LIKE
TRANSCRIPT-1

(Homo sapiens) 		no annotation 3 SER P  64
ALA P  66
VAL P  67
 None
 0.38A 4x20C-2frgP:
undetectable		 4x20C-2frgP:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuk XC6422 PROTEIN

(Xanthomonas
campestris) 		PF12146
(Hydrolase_4) 		3 SER A  10
ALA A  25
VAL A  24
 None
 0.55A 4x20C-2fukA:
undetectable		 4x20C-2fukA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjn HYPOTHETICAL PROTEIN
PA1024

(Pseudomonas
aeruginosa) 		PF03060
(NMO) 		3 SER A 227
ALA A 242
VAL A 241
 None
 0.58A 4x20C-2gjnA:
undetectable		 4x20C-2gjnA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gju 252AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		no annotation 3 SER A 194
ALA A 174
VAL A 173
 None
 0.50A 4x20C-2gjuA:
undetectable		 4x20C-2gjuA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gnw NON-SYMBIOTIC
HEMOGLOBIN 1

(Oryza sativa) 		PF00042
(Globin) 		3 SER A  12
ALA A  10
VAL A   9
 None
 0.63A 4x20C-2gnwA:
undetectable		 4x20C-2gnwA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw3 KAEDE

(Trachyphyllia
geoffroyi) 		PF01353
(GFP) 		3 SER A 218
ALA A 216
VAL A 215
 None
 0.58A 4x20C-2gw3A:
undetectable		 4x20C-2gw3A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gw4 KAEDE

(Trachyphyllia
geoffroyi) 		PF01353
(GFP) 		3 SER B 218
ALA B 216
VAL B 215
 None
 0.58A 4x20C-2gw4B:
undetectable		 4x20C-2gw4B:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6v GENERAL SECRETION
PATHWAY PROTEIN C

(Vibrio cholerae) 		no annotation 3 SER A 289
ALA A 263
VAL A 262
 None
 0.64A 4x20C-2i6vA:
undetectable		 4x20C-2i6vA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iks DNA-BINDING
TRANSCRIPTIONAL DUAL
REGULATOR

(Escherichia
coli) 		PF00532
(Peripla_BP_1) 		3 SER A 124
ALA A 146
VAL A 145
 None
 0.57A 4x20C-2iksA:
undetectable		 4x20C-2iksA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k9u FILAMIN-BINDING LIM
PROTEIN 1

(Homo sapiens) 		no annotation 3 SER B  12
ALA B  10
VAL B   9
 None
 0.66A 4x20C-2k9uB:
undetectable		 4x20C-2k9uB:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2khc TESTIS-SPECIFIC
RNP-TYPE RNA BINDING
PROTEIN

(Drosophila
melanogaster) 		PF00076
(RRM_1) 		3 SER A 503
ALA A 501
VAL A 500
 None
 0.54A 4x20C-2khcA:
undetectable		 4x20C-2khcA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkz RNA-BINDING PROTEIN
5

(Homo sapiens) 		PF00076
(RRM_1) 		3 SER A  35
ALA A  37
VAL A  38
 None
 0.65A 4x20C-2lkzA:
undetectable		 4x20C-2lkzA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mfi 30S RIBOSOMAL
PROTEIN S1

(Escherichia
coli) 		PF00575
(S1) 		3 SER A  22
ALA A  71
VAL A  70
 None
 0.37A 4x20C-2mfiA:
undetectable		 4x20C-2mfiA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n51 ELONGATION FACTOR
1-DELTA

(Homo sapiens) 		PF00736
(EF1_GNE)
PF10587
(EF-1_beta_acid) 		3 SER A 196
ALA A 194
VAL A 193
 None
 0.55A 4x20C-2n51A:
undetectable		 4x20C-2n51A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n7y COPPER-TRANSPORTING
ATPASE 2

(Homo sapiens) 		PF00403
(HMA) 		3 SER A   9
ALA A   7
VAL A   6
 None
 0.64A 4x20C-2n7yA:
undetectable		 4x20C-2n7yA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nn6 EXOSOME COMPLEX
EXONUCLEASE RRP43

(Homo sapiens) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		3 SER C 197
ALA C 195
VAL C 194
 None
 0.66A 4x20C-2nn6C:
undetectable		 4x20C-2nn6C:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oo4 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 2

(Homo sapiens) 		PF00066
(Notch)
PF06816
(NOD)
PF07684
(NODP) 		3 SER A1621
ALA A1619
VAL A1618
 None
 0.56A 4x20C-2oo4A:
undetectable		 4x20C-2oo4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4u ACID PHOSPHATASE 1

(Mus musculus) 		PF01451
(LMWPc) 		3 SER A  44
ALA A  46
VAL A  47
 None
 0.39A 4x20C-2p4uA:
undetectable		 4x20C-2p4uA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6p GLYCOSYL TRANSFERASE

(Streptomyces
fradiae) 		PF06722
(DUF1205) 		3 SER A 195
ALA A 193
VAL A 192
 None
 0.32A 4x20C-2p6pA:
4.9		 4x20C-2p6pA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF16073
(SAT) 		3 SER B 295
ALA B 299
VAL B 302
 None
 0.66A 4x20C-2pffB:
undetectable		 4x20C-2pffB:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpt EH DOMAIN-CONTAINING
PROTEIN-2

(Mus musculus) 		PF00350
(Dynamin_N)
PF12763
(EF-hand_4)
PF16880
(EHD_N) 		3 SER A 150
ALA A  99
VAL A  98
 None
 0.65A 4x20C-2qptA:
undetectable		 4x20C-2qptA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v24 SPRY
DOMAIN-CONTAINING
SOCS BOX PROTEIN 4

(Homo sapiens) 		PF00622
(SPRY) 		3 SER A 147
ALA A 160
VAL A 159
 None
 0.64A 4x20C-2v24A:
undetectable		 4x20C-2v24A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w1v NITRILASE HOMOLOG 2

(Mus musculus) 		PF00795
(CN_hydrolase) 		3 SER A 260
ALA A 242
VAL A 241
 None
 0.48A 4x20C-2w1vA:
undetectable		 4x20C-2w1vA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wym L-ASCORBATE-6-PHOSPH
ATE LACTONASE ULAG

(Escherichia
coli) 		PF13483
(Lactamase_B_3) 		3 SER A 224
ALA A 245
VAL A 244
 None
 0.43A 4x20C-2wymA:
undetectable		 4x20C-2wymA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Heterobasidion
annosum) 		PF00840
(Glyco_hydro_7) 		3 SER A 224
ALA A 226
VAL A 227
 None
 0.51A 4x20C-2yg1A:
undetectable		 4x20C-2yg1A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygl BLOOD GROUP A-AND
B-CLEAVING
ENDO-BETA-GALACTOSID
ASE

(Streptococcus
pneumoniae) 		PF08305
(NPCBM) 		3 SER A 126
ALA A 124
VAL A 123
 None
 0.58A 4x20C-2yglA:
undetectable		 4x20C-2yglA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yha POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa) 		PF02171
(Piwi) 		3 SER A 934
ALA A 699
VAL A 687
 None
 0.62A 4x20C-2yhaA:
undetectable		 4x20C-2yhaA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhb POST-TRANSCRIPTIONAL
GENE SILENCING
PROTEIN QDE-2

(Neurospora
crassa) 		PF02171
(Piwi) 		3 SER A 934
ALA A 699
VAL A 687
 None
 0.59A 4x20C-2yhbA:
undetectable		 4x20C-2yhbA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yux MYOSIN-BINDING
PROTEIN C, SLOW-TYPE

(Homo sapiens) 		PF00041
(fn3) 		3 SER A  75
ALA A  35
VAL A  34
 None
 0.54A 4x20C-2yuxA:
undetectable		 4x20C-2yuxA:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpa UNCHARACTERIZED
PROTEIN YPFI

(Escherichia
coli) 		PF05127
(Helicase_RecD)
PF08351
(DUF1726)
PF13718
(GNAT_acetyltr_2)
PF17176
(tRNA_bind_3) 		3 SER A 100
ALA A  76
VAL A  77
 None
 0.61A 4x20C-2zpaA:
undetectable		 4x20C-2zpaA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsc TAMAVIDIN2

(Pleurotus
cornucopiae) 		PF01382
(Avidin) 		3 SER A  81
ALA A  62
VAL A  61
 None
None
GOL  A1810 (-4.5A)
 0.61A 4x20C-2zscA:
undetectable		 4x20C-2zscA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akc CYTIDYLATE KINASE

(Thermus
thermophilus) 		PF02224
(Cytidylate_kin) 		3 SER A  33
ALA A 123
VAL A 122
 CDP  A 209 (-3.1A)
None
None
 0.64A 4x20C-3akcA:
undetectable		 4x20C-3akcA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aoh ANTI-CLEAVAGE
ANTI-GREA
TRANSCRIPTION FACTOR
GFH1

(Thermus
thermophilus) 		PF01272
(GreA_GreB)
PF03449
(GreA_GreB_N) 		3 SER X  70
ALA X  72
VAL X  73
 None
 0.66A 4x20C-3aohX:
undetectable		 4x20C-3aohX:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE

(Homo sapiens) 		PF00198
(2-oxoacid_dh) 		3 SER A 430
ALA A 428
VAL A 427
 None
 0.52A 4x20C-3b8kA:
undetectable		 4x20C-3b8kA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htd ATROLYSIN C

(Crotalus atrox) 		PF01421
(Reprolysin) 		5 LEU A  47
LEU A 148
ASN A 147
MET A 116
ILE A 198
 None
 1.02A 4x20D-1htdA:
undetectable		 4x20D-1htdA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixx COAGULATION FACTORS
IX/X-BINDING PROTEIN

(Protobothrops
flavoviridis) 		PF00059
(Lectin_C) 		5 ASN A  58
MET A  59
VAL A  40
LYS A  15
ILE A  66
 None
 1.13A 4x20D-1ixxA:
undetectable		 4x20D-1ixxA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy1 ATP-DEPENDENT
METALLOPROTEASE FTSH

(Thermus
thermophilus) 		PF00004
(AAA) 		5 LEU A 283
LEU A 311
THR A 301
ALA A 299
VAL A 297
 None
 1.01A 4x20D-1iy1A:
undetectable		 4x20D-1iy1A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy2 ATP-DEPENDENT
METALLOPROTEASE FTSH

(Thermus
thermophilus) 		PF00004
(AAA) 		5 LEU A 283
LEU A 311
THR A 301
ALA A 299
VAL A 297
 None
 0.95A 4x20D-1iy2A:
undetectable		 4x20D-1iy2A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1izo CYTOCHROME P450
152A1

(Bacillus
subtilis) 		PF00067
(p450) 		5 LEU A 241
LEU A 102
LEU A 214
ALA A 218
ILE A 198
 None
 1.07A 4x20D-1izoA:
undetectable		 4x20D-1izoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1u TYROSYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00579
(tRNA-synt_1b) 		5 LEU A  24
LEU A  55
MET A  52
VAL A 189
ILE A 191
 None
 1.09A 4x20D-1j1uA:
undetectable		 4x20D-1j1uA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp1 P40 NUCLEOPROTEIN

(Borna disease
virus) 		PF06407
(BDV_P40) 		5 LEU X 144
LEU X 211
ALA X 233
VAL X 229
ILE X 149
 None
 1.15A 4x20D-1pp1X:
undetectable		 4x20D-1pp1X:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		5 LEU A 299
LYS A  21
ASN A  25
MET A  26
ALA A 274
 None
 1.10A 4x20D-1qjmA:
undetectable		 4x20D-1qjmA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR

(Bacillus
megaterium) 		no annotation 5 LEU G 234
ASN G 179
ALA G 181
VAL G 217
ILE G 243
 None
 1.09A 4x20D-1rzrG:
undetectable		 4x20D-1rzrG:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG

(Mus musculus) 		PF00225
(Kinesin) 		5 MET A  81
ALA A 326
VAL A 328
LYS A   7
ILE A  93
 None
 1.10A 4x20D-1vfwA:
undetectable		 4x20D-1vfwA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wni TRIMERELYSIN II

(Protobothrops
flavoviridis) 		PF01421
(Reprolysin) 		5 LEU A  47
LEU A 148
ASN A 147
MET A 116
ILE A 197
 None
 1.07A 4x20D-1wniA:
undetectable		 4x20D-1wniA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp1 FII

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		5 LEU A  47
LEU A 148
ASN A 147
MET A 116
ILE A 197
 None
 0.98A 4x20D-1yp1A:
undetectable		 4x20D-1yp1A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 LEU A 410
LEU A 436
ASN A 437
LYS A 441
ILE A 397
 None
 0.90A 4x20D-2bucA:
undetectable		 4x20D-2bucA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cnd NADH-DEPENDENT
NITRATE REDUCTASE

(Zea mays) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		5 LEU A  17
LEU A  78
LEU A 101
MET A  97
VAL A 112
 None
 1.16A 4x20D-2cndA:
undetectable		 4x20D-2cndA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		5 LEU A  47
LEU A 183
LEU A 206
ASN A 204
ILE A 304
 None
 1.14A 4x20D-2dh4A:
undetectable		 4x20D-2dh4A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhr FTSH

(Thermus
thermophilus) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		5 LEU A 283
LEU A 311
ALA A 299
VAL A 297
ILE A 257
 None
 1.10A 4x20D-2dhrA:
undetectable		 4x20D-2dhrA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyk GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1) 		5 LEU A  17
LEU A  84
VAL A  44
LYS A   3
ILE A 156
 None
 1.02A 4x20D-2dykA:
5.0		 4x20D-2dykA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B

(Homo sapiens) 		PF14580
(LRR_9) 		5 LEU A 113
LEU A 122
LEU A 102
ASN A 101
ILE A  83
 None
 1.19A 4x20D-2ellA:
undetectable		 4x20D-2ellA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B

(Homo sapiens) 		PF14580
(LRR_9) 		5 LEU A 116
LEU A  97
LEU A 102
ASN A 101
ILE A  83
 None
 1.18A 4x20D-2ellA:
undetectable		 4x20D-2ellA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewy BETA-SECRETASE 2

(Homo sapiens) 		PF00026
(Asp) 		5 LEU A 343
LEU A 300
LEU A 219
VAL A 349
ILE A 296
 None
 1.19A 4x20D-2ewyA:
undetectable		 4x20D-2ewyA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7l 455AA LONG
HYPOTHETICAL
PHOSPHO-SUGAR MUTASE

(Sulfurisphaera
tokodaii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 LEU A 348
LYS A 273
ASN A 274
ALA A 323
ILE A 281
 None
 1.18A 4x20D-2f7lA:
undetectable		 4x20D-2f7lA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gas ISOFLAVONE REDUCTASE

(Medicago sativa) 		PF05368
(NmrA) 		5 LEU A  10
THR A  80
ALA A  84
VAL A  88
ILE A  85
 None
 1.10A 4x20D-2gasA:
6.9		 4x20D-2gasA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6e HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF02621
(VitK2_biosynth) 		5 LEU A 220
LEU A  34
ASN A  63
ALA A  19
VAL A  40
 None
 1.08A 4x20D-2i6eA:
undetectable		 4x20D-2i6eA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix5 ACYL-COENZYME A
OXIDASE 4,
PEROXISOMAL

(Arabidopsis
thaliana) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A 284
LEU A 174
THR A 188
VAL A 274
ILE A 227
 CAA  A1432 (-4.2A)
FAD  A1433 (-4.4A)
None
None
None
 1.06A 4x20D-2ix5A:
undetectable		 4x20D-2ix5A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kzf RIBOSOME-BINDING
FACTOR A

(Thermotoga
maritima) 		PF02033
(RBFA) 		5 LEU A  18
LEU A  11
ALA A  50
VAL A  41
ILE A  93
 None
 1.03A 4x20D-2kzfA:
undetectable		 4x20D-2kzfA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz4 PARAPLEGIN

(Homo sapiens) 		PF00004
(AAA) 		5 LEU A 437
LEU A 465
THR A 455
ALA A 453
VAL A 451
 None
 1.15A 4x20D-2qz4A:
undetectable		 4x20D-2qz4A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2va0 ABFS
ARABINOFURANOSIDASE
TWO COMPONENT SYSTEM
SENSOR PROTEIN

(Cellvibrio
japonicus) 		no annotation 5 LEU A  95
LEU A 134
ASN A 138
VAL A 142
ILE A 132
 None
None
None
None
CL  A1149 ( 4.6A)
 1.14A 4x20D-2va0A:
undetectable		 4x20D-2va0A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Homo sapiens) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 LEU A 411
LEU A 426
ASN A 257
ALA A 259
ILE A 230
 None
 1.10A 4x20D-2vxoA:
undetectable		 4x20D-2vxoA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w21 GLUTAMATE 5-KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		5 LEU A 155
LEU A 121
ALA A 162
VAL A   8
ILE A 229
 None
 1.15A 4x20D-2w21A:
undetectable		 4x20D-2w21A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wcu PROTEIN FUCU HOMOLOG

(Mus musculus) 		PF05025
(RbsD_FucU) 		5 LEU A  11
LEU A  19
MET A  22
VAL A 130
ILE A  28
 None
 1.09A 4x20D-2wcuA:
undetectable		 4x20D-2wcuA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 LEU A 688
LEU A 598
THR A 724
ALA A 715
ILE A  79
 None
PGR  A1742 (-4.0A)
None
None
None
 1.15A 4x20D-2xe4A:
undetectable		 4x20D-2xe4A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ygt DELTA TOXIN

(Clostridium
perfringens) 		PF07968
(Leukocidin) 		5 LYS A 239
LEU A 279
ALA A  48
VAL A  46
ILE A  63
 None
 1.11A 4x20D-2ygtA:
undetectable		 4x20D-2ygtA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1

(Homo sapiens) 		PF02144
(Rad1) 		5 LEU C  90
LEU C  27
ALA C  63
VAL C  51
ILE C  34
 None
 1.15A 4x20D-3a1jC:
undetectable		 4x20D-3a1jC:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 377
LEU A 395
LEU A 350
ALA A 341
ILE A 339
 None
 1.02A 4x20D-3b2dA:
undetectable		 4x20D-3b2dA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47

(Homo sapiens) 		PF00270
(DEAD) 		5 LEU A 192
LEU A 220
LEU A 215
ALA A 176
ILE A 179
 PGE  A 401 (-3.9A)
None
None
None
None
 1.14A 4x20D-3berA:
undetectable		 4x20D-3berA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsl ZINC
METALLOPROTEINASE-DI
SINTEGRIN
BOTHROPASIN

(Bothrops
jararaca) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		5 LEU A  50
LEU A 151
ASN A 150
MET A 119
ILE A 201
 None
 1.05A 4x20D-3dslA:
undetectable		 4x20D-3dslA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1g CHEMOTAXIS PROTEIN
CHEY HOMOLOG

(Helicobacter
pylori) 		PF00072
(Response_reg) 		5 LEU A  64
LYS A  40
LEU A  41
ASN A  44
ILE A  77
 None
 0.97A 4x20D-3h1gA:
4.9		 4x20D-3h1gA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR

(Homo sapiens) 		PF00079
(Serpin) 		5 LEU A 299
LEU A 304
ASN A 306
MET A 307
VAL A 280
 None
 1.17A 4x20D-3h5cA:
undetectable		 4x20D-3h5cA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig4 XAA-PRO
AMINOPEPTIDASE

(Bacillus
anthracis) 		PF00557
(Peptidase_M24)
PF05195
(AMP_N) 		5 LEU A 207
LEU A 195
ASN A 416
MET A 412
ILE A 408
 None
 1.18A 4x20D-3ig4A:
undetectable		 4x20D-3ig4A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4s FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		5 LEU A 388
LEU A 183
THR A 143
ALA A 137
ILE A 166
 None
 1.16A 4x20D-3j4sA:
20.4		 4x20D-3j4sA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2

(Schizosaccharomyces
pombe) 		PF01423
(LSM) 		5 LEU G 101
ASN G  65
MET G  66
VAL G 107
ILE G  45
 None
U  C 101 ( 3.2A)
None
None
None
 1.13A 4x20D-3jb9G:
undetectable		 4x20D-3jb9G:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k53 FERROUS IRON
TRANSPORT PROTEIN B

(Pyrococcus
furiosus) 		PF02421
(FeoB_N) 		5 ASN A  81
THR A   5
ALA A   7
VAL A   9
ILE A  85
 None
 0.93A 4x20D-3k53A:
4.6		 4x20D-3k53A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m5r NONSTRUCTURAL
PROTEIN 1

(Influenza A
virus) 		PF00600
(Flu_NS1) 		5 LEU A 181
LEU A 115
LEU A 147
ALA A 202
ILE A 198
 None
 1.14A 4x20D-3m5rA:
undetectable		 4x20D-3m5rA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mha LIPOPROTEIN LPRG

(Mycobacterium
tuberculosis) 		PF07161
(LppX_LprAFG) 		5 LEU A 111
THR A 116
ALA A 102
VAL A  91
ILE A 100
 Z69  A   1 ( 4.8A)
None
Z69  A   1 ( 4.9A)
Z69  A   1 (-4.8A)
None
 0.97A 4x20D-3mhaA:
undetectable		 4x20D-3mhaA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvk PROTEIN FUCU

(Bifidobacterium
longum) 		PF05025
(RbsD_FucU) 		5 LEU A  60
LEU A  17
LYS A 141
LEU A 139
ILE A  28
 None
 1.10A 4x20D-3mvkA:
undetectable		 4x20D-3mvkA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mw8 UROPORPHYRINOGEN-III
SYNTHASE

(Shewanella
amazonensis) 		PF02602
(HEM4) 		5 LEU A 109
LEU A 114
THR A  76
VAL A  80
ILE A  54
 None
 1.12A 4x20D-3mw8A:
undetectable		 4x20D-3mw8A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A  -1
LEU A 309
ASN A 307
ALA A  15
ILE A 106
 None
 1.18A 4x20D-3oc4A:
undetectable		 4x20D-3oc4A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 377
LEU A 395
LEU A 350
ALA A 341
ILE A 339
 None
 1.03A 4x20D-3rg1A:
undetectable		 4x20D-3rg1A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		5 LEU A 377
LEU A 395
LEU A 350
ALA A 341
ILE A 339
 None
 0.98A 4x20D-3t6qA:
undetectable		 4x20D-3t6qA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfw PUTATIVE
O-METHYLTRANSFERASE

(Klebsiella
pneumoniae) 		PF01596
(Methyltransf_3) 		5 LEU A 151
THR A 218
ALA A 220
VAL A 222
ILE A 164
 None
 1.02A 4x20D-3tfwA:
3.9		 4x20D-3tfwA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		5 LEU A  43
LEU A  20
THR A   8
ALA A   6
ILE A  57
 None
 1.17A 4x20D-3v8vA:
3.5		 4x20D-3v8vA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vs8 TYPE III POLYKETIDE
SYNTHASE

(Azotobacter
vinelandii) 		PF02797
(Chal_sti_synt_C) 		5 LEU A 377
LEU A 404
MET A 270
VAL A 251
ILE A 267
 None
 1.16A 4x20D-3vs8A:
undetectable		 4x20D-3vs8A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A

(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 LEU A 309
LEU A 337
THR A 327
ALA A 325
VAL A 323
 LEU  A 309 ( 0.6A)
LEU  A 337 ( 0.6A)
THR  A 327 ( 0.8A)
ALA  A 325 ( 0.0A)
VAL  A 323 ( 0.6A)
 0.93A 4x20D-3whlA:
undetectable		 4x20D-3whlA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A

(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 LEU A 309
THR A 327
ALA A 325
VAL A 323
ILE A 280
 LEU  A 309 ( 0.6A)
THR  A 327 ( 0.8A)
ALA  A 325 ( 0.0A)
VAL  A 323 ( 0.6A)
ILE  A 280 ( 0.7A)
 1.09A 4x20D-3whlA:
undetectable		 4x20D-3whlA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2q RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		5 LEU A 612
LEU A 619
LEU A 644
THR A 698
VAL A 742
 None
 1.13A 4x20D-4a2qA:
undetectable		 4x20D-4a2qA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2w RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		5 LEU A 612
LEU A 619
LEU A 644
THR A 698
VAL A 742
 None
 1.13A 4x20D-4a2wA:
undetectable		 4x20D-4a2wA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buj ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT) 		5 LEU A1150
LEU A1171
ALA A1219
VAL A1215
ILE A1275
 None
 1.06A 4x20D-4bujA:
undetectable		 4x20D-4bujA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE

(Oceanicola
granulosus) 		PF00294
(PfkB) 		5 LEU A  37
LEU A 262
ALA A 159
VAL A 125
ILE A 188
 None
 0.91A 4x20D-4e69A:
5.5		 4x20D-4e69A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		5 LEU A 250
ASN A 347
MET A 348
VAL A  26
ILE A  24
 None
 0.99A 4x20D-4fidA:
2.9		 4x20D-4fidA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h41 PUTATIVE
ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF14488
(DUF4434)
PF17134
(DUF5109) 		5 LEU A 355
LYS A 318
LEU A 319
THR A 298
ILE A  60
 None
 1.15A 4x20D-4h41A:
3.3		 4x20D-4h41A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3u ALDEHYDE
DEHYDROGENASE (NAD+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 LEU A 202
ASN A 175
ALA A 171
VAL A 168
ILE A 151
 None
 1.15A 4x20D-4i3uA:
undetectable		 4x20D-4i3uA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4m ZINC-DEPENDENT
METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		5 LEU A  49
LEU A 150
ASN A 149
MET A 118
ILE A 199
 None
 1.05A 4x20D-4j4mA:
undetectable		 4x20D-4j4mA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhl INTERLEUKIN-11

(Homo sapiens) 		PF07400
(IL11) 		5 LEU A  78
LEU A  75
ASN A  71
ALA A 176
ILE A 177
 None
 1.15A 4x20D-4mhlA:
undetectable		 4x20D-4mhlA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qmk TYPE III SECRETION
SYSTEM EFFECTOR
PROTEIN EXOU

(Pseudomonas
fluorescens) 		PF01734
(Patatin) 		5 LEU A 441
LEU A 448
ASN A 450
VAL A  30
ILE A  37
 None
 1.08A 4x20D-4qmkA:
undetectable		 4x20D-4qmkA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5c LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 147
LEU A 192
ASN A 186
THR A 184
VAL A 199
 None
 1.13A 4x20D-4r5cA:
undetectable		 4x20D-4r5cA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7z CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus) 		PF00493
(MCM) 		5 LEU A 325
LEU A 338
LEU A 761
MET A 764
ILE A 772
 None
 1.04A 4x20D-4r7zA:
undetectable		 4x20D-4r7zA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3B

(Lachancea
kluyveri) 		PF00318
(Ribosomal_S2) 		5 LEU b 603
ALA b 651
VAL b 649
LYS b 665
ILE b 640
 None
 0.92A 4x20D-4uerb:
undetectable		 4x20D-4uerb:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzy FLAGELLAR ASSOCIATED
PROTEIN

(Chlamydomonas
reinhardtii) 		PF12895
(ANAPC3)
PF13174
(TPR_6) 		5 LEU A 453
LEU A 495
ASN A 494
ALA A 469
ILE A 470
 None
 1.17A 4x20D-4uzyA:
undetectable		 4x20D-4uzyA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjn NUCLEOCAPSID

(Mammalian
rubulavirus 5) 		PF00973
(Paramyxo_ncap) 		5 LEU A  73
THR A 178
ALA A 174
VAL A 170
ILE A 219
 None
 0.98A 4x20D-4xjnA:
undetectable		 4x20D-4xjnA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z1p CELL WALL SURFACE
ANCHOR PROTEIN

(Streptococcus
agalactiae) 		PF16364
(Antigen_C) 		5 LEU A  90
LEU A  97
ALA A  50
VAL A  52
ILE A 155
 None
 1.08A 4x20D-4z1pA:
undetectable		 4x20D-4z1pA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zem TRANSLATION
INITIATION FACTOR
EIF2B-LIKE
PROTEIN,TRANSLATION
INITIATION FACTOR
EIF2B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF01008
(IF-2B) 		5 LEU A 265
LYS A 228
ALA A 223
VAL A 245
ILE A 295
 None
 1.13A 4x20D-4zemA:
3.1		 4x20D-4zemA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE

(Thosea asigna
virus) 		no annotation 5 LEU B 517
LEU B 513
LEU B 329
MET B 307
ALA B 347
 None
 1.18A 4x20D-5cyrB:
undetectable		 4x20D-5cyrB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		5 LEU A 298
LEU A 412
THR A 152
ALA A 123
VAL A 127
 None
 1.04A 4x20D-5e78A:
undetectable		 4x20D-5e78A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48

(Mycolicibacterium
smegmatis) 		PF00004
(AAA)
PF02359
(CDC48_N) 		5 LEU A 454
LEU A 439
ALA A 166
VAL A 169
ILE A 171
 None
 1.16A 4x20D-5e7pA:
undetectable		 4x20D-5e7pA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE

(Pyrococcus
horikoshii) 		PF00004
(AAA) 		5 LEU A 234
LEU A 262
THR A 252
ALA A 250
VAL A 248
 None
 0.88A 4x20D-5eqtA:
undetectable		 4x20D-5eqtA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE

(Pyrococcus
horikoshii) 		PF00004
(AAA) 		5 LEU A 234
THR A 252
ALA A 250
VAL A 248
ILE A 205
 None
 1.11A 4x20D-5eqtA:
undetectable		 4x20D-5eqtA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 NICASTRIN

(Homo sapiens) 		PF05450
(Nicastrin) 		5 LEU A 312
LEU A 494
THR A 280
ALA A 278
VAL A 276
 None
 0.87A 4x20D-5fn4A:
4.3		 4x20D-5fn4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT RRP42

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU E 103
LEU E 149
ASN E 150
VAL E  60
ILE E  62
 None
 1.12A 4x20D-5g06E:
undetectable		 4x20D-5g06E:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4l OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Clostridium sp.) 		PF13561
(adh_short_C2) 		5 LEU A  33
LEU A 240
ALA A  42
VAL A  44
LYS A  18
 None
 1.15A 4x20D-5g4lA:
6.9		 4x20D-5g4lA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		5 LEU A 786
LEU A 689
LEU A 782
VAL A 754
ILE A 780
 None
 1.05A 4x20D-5gl7A:
undetectable		 4x20D-5gl7A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6o PORPHOBILINOGEN
DEAMINASE

(Vibrio cholerae) 		no annotation 5 LEU A 244
ASN A 241
MET A 240
ALA A 267
VAL A 278
 None
 1.14A 4x20D-5h6oA:
undetectable		 4x20D-5h6oA:
22.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 LEU A 253
MET A 257
THR A 311
ALA A 313
ILE A 367
 None
 1.12A 4x20D-5mjsA:
53.0		 4x20D-5mjsA:
58.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 LYS A 252
MET A 257
THR A 311
ALA A 313
ILE A 367
 None
 1.17A 4x20D-5mjsA:
53.0		 4x20D-5mjsA:
58.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 LEU B 252
THR B 314
ALA B 316
VAL B 318
ILE B 378
 None
 1.04A 4x20D-5n5nB:
53.4		 4x20D-5n5nB:
97.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 LEU B 255
ASN B 258
MET B 259
THR B 314
ILE B 378
 None
 0.98A 4x20D-5n5nB:
53.4		 4x20D-5n5nB:
97.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 LEU B 255
MET B 259
THR B 314
ALA B 316
ILE B 378
 None
 1.06A 4x20D-5n5nB:
53.4		 4x20D-5n5nB:
97.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 LYS B 254
ASN B 258
MET B 259
THR B 314
ILE B 378
 None
 0.77A 4x20D-5n5nB:
53.4		 4x20D-5n5nB:
97.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 MET B 259
THR B 314
ALA B 316
VAL B 318
ILE B 378
 None
 0.77A 4x20D-5n5nB:
53.4		 4x20D-5n5nB:
97.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swv PENTAFUNCTIONAL AROM
POLYPEPTIDE

(Schizosaccharomyces
pombe) 		PF01487
(DHquinase_I)
PF08501
(Shikimate_dh_N) 		5 LYS C1338
LEU C1340
ALA C1348
VAL C1350
ILE C1378
 None
 0.84A 4x20D-5swvC:
undetectable		 4x20D-5swvC:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t67 SUGAR 3-C-METHYL
TRANSFERASE

(Actinomadura
kijaniata) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		5 LEU A 185
ASN A 177
ALA A 175
VAL A 202
ILE A 112
 None
SAH  A 502 ( 3.7A)
None
None
SAH  A 502 (-4.4A)
 1.09A 4x20D-5t67A:
2.9		 4x20D-5t67A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		6 LEU A 217
LEU A 259
MET A 262
ALA A 236
VAL A 238
ILE A 265
 None
 1.41A 4x20D-5tvjA:
undetectable		 4x20D-5tvjA:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 LEU B 253
ASN B 256
THR B 312
ALA B 314
ILE B 368
 None
 0.87A 4x20D-5w3jB:
53.2		 4x20D-5w3jB:
75.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wkn NUCLEOPROTEIN

(Mammalian
rubulavirus 5) 		no annotation 5 LEU A  73
THR A 178
ALA A 174
VAL A 170
ILE A 219
 None
 1.08A 4x20D-5wknA:
undetectable		 4x20D-5wknA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa2 CYSTEINE SYNTHASE

(Planctopirus
limnophila) 		PF00291
(PALP) 		5 LEU A 255
MET A 271
ALA A  32
VAL A  17
ILE A  19
 None
 1.11A 4x20D-5xa2A:
undetectable		 4x20D-5xa2A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5c KATANIN P60
ATPASE-CONTAINING
SUBUNIT A-LIKE 1

(Homo sapiens) 		no annotation 5 LEU A 333
LEU A 368
THR A 358
ALA A 356
VAL A 354
 None
 0.88A 4x20D-6b5cA:
undetectable		 4x20D-6b5cA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5c KATANIN P60
ATPASE-CONTAINING
SUBUNIT A-LIKE 1

(Homo sapiens) 		no annotation 5 LEU A 333
THR A 358
ALA A 356
VAL A 354
ILE A 306
 None
 1.15A 4x20D-6b5cA:
undetectable		 4x20D-6b5cA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf6 INSULIN-DEGRADING
ENZYME

(Homo sapiens) 		no annotation 6 LEU A 642
LEU A 616
LEU A 574
ASN A 573
LYS A 571
ILE A 733
 None
 1.28A 4x20D-6bf6A:
undetectable		 4x20D-6bf6A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9e CYSTEINE DESULFURASE

(Legionella
pneumophila) 		no annotation 5 LYS A 168
LEU A 169
ASN A 170
ALA A 203
VAL A 205
 None
 1.18A 4x20D-6c9eA:
undetectable		 4x20D-6c9eA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 10
N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT

(Homo sapiens) 		no annotation 5 LEU A 541
LEU B  11
ASN B  13
MET B  14
ALA B   6
 None
 0.99A 4x20D-6c9mA:
undetectable		 4x20D-6c9mA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e29 -

(-) 		no annotation 5 LEU D  92
LEU D  95
ASN D  33
ALA D  40
VAL D  48
 None
 1.09A 4x20D-6e29D:
undetectable		 4x20D-6e29D:
undetectable