SIMILAR PATTERNS OF AMINO ACIDS FOR 4X20_B_LOCB502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmu BGLI RESTRICTION
ENDONUCLEASE


(Bacillus
subtilis)
PF14562
(Endonuc_BglI)
5 LEU A 155
LEU A 261
VAL A 292
ALA A 238
ILE A 288
None
1.01A 4x20B-1dmuA:
undetectable
4x20B-1dmuA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4a L-FUCULOSE
1-PHOSPHATE ALDOLASE


(Escherichia
coli)
PF00596
(Aldolase_II)
5 CYH P  14
LEU P  15
LEU P  50
VAL P  30
ILE P  55
BME  P 303 (-2.0A)
None
None
BME  P 303 ( 4.8A)
None
0.99A 4x20B-1e4aP:
undetectable
4x20B-1e4aP:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g65 PROTEASOME COMPONENT
PUP3


(Saccharomyces
cerevisiae)
PF00227
(Proteasome)
5 ALA I 158
LEU I 160
ALA I 173
VAL I 175
ALA I  15
None
0.88A 4x20B-1g65I:
undetectable
4x20B-1g65I:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME


(Homo sapiens)
PF00390
(malic)
PF03949
(Malic_M)
5 LEU A 512
ALA A 293
LEU A 291
ALA A 444
ILE A 390
None
1.02A 4x20B-1gz4A:
3.6
4x20B-1gz4A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy2 ATP-DEPENDENT
METALLOPROTEASE FTSH


(Thermus
thermophilus)
PF00004
(AAA)
5 LEU A 283
LEU A 311
THR A 301
ALA A 299
VAL A 297
None
0.98A 4x20B-1iy2A:
0.0
4x20B-1iy2A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j33 COBT

(Thermus
thermophilus)
PF02277
(DBI_PRT)
5 LEU A 260
ALA A 256
ASN A 167
ALA A  52
ALA A 160
None
0.95A 4x20B-1j33A:
3.1
4x20B-1j33A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdi L-RIBULOSE 5
PHOSPHATE
4-EPIMERASE


(Escherichia
coli)
PF00596
(Aldolase_II)
5 LEU A 190
ALA A 101
THR A 145
VAL A  94
ALA A 175
None
1.02A 4x20B-1jdiA:
undetectable
4x20B-1jdiA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jg3 PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE


(Pyrococcus
furiosus)
PF01135
(PCMT)
5 LEU A  89
ASN A  88
VAL A  80
ALA A  81
ILE A 163
None
0.97A 4x20B-1jg3A:
0.0
4x20B-1jg3A:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3v CAPSID PROTEIN VP2

(Ungulate
protoparvovirus
1)
PF00740
(Parvo_coat)
5 LEU A  86
ALA A 101
LEU A 218
ASN A 217
ILE A 230
None
1.04A 4x20B-1k3vA:
0.0
4x20B-1k3vA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks8 ENDO-B-1,4-GLUCANASE

(Nasutitermes
takasagoensis)
PF00759
(Glyco_hydro_9)
5 LEU A 184
LEU A 177
ALA A  99
LYS A  97
ALA A 162
None
0.97A 4x20B-1ks8A:
undetectable
4x20B-1ks8A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION


(Bacillus
subtilis)
PF01256
(Carb_kinase)
5 CYH A 227
LEU A  55
ALA A 100
ALA A  30
ILE A 126
None
0.94A 4x20B-1kyhA:
undetectable
4x20B-1kyhA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A


(Thermobifida
fusca)
PF00079
(Serpin)
5 LEU A 145
THR A 298
ALA A 319
ALA A 317
ILE A 157
None
0.87A 4x20B-1mtpA:
undetectable
4x20B-1mtpA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE


(Rhodotorula
toruloides)
PF00221
(Lyase_aromatic)
5 LEU A 386
ASN A 420
THR A 489
ALA A 506
ALA A 279
None
0.89A 4x20B-1t6pA:
undetectable
4x20B-1t6pA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tig TRANSLATION
INITIATION FACTOR 3


(Geobacillus
stearothermophilus)
PF00707
(IF3_C)
5 CYH A 144
LEU A 110
ALA A 148
ALA A 118
ALA A 106
None
0.90A 4x20B-1tigA:
undetectable
4x20B-1tigA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlt PUTATIVE
OXIDOREDUCTASE
(VIRULENCE FACTOR
MVIM HOMOLOG)


(Escherichia
coli)
PF01408
(GFO_IDH_MocA)
5 LEU A 164
LEU A  98
ALA A  99
LEU A 102
ALA A 292
None
1.05A 4x20B-1tltA:
4.2
4x20B-1tltA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umf CHORISMATE SYNTHASE

(Helicobacter
pylori)
PF01264
(Chorismate_synt)
5 CYH A 335
LEU A 338
THR A 298
VAL A 293
ALA A 204
None
1.04A 4x20B-1umfA:
undetectable
4x20B-1umfA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vic 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE


(Haemophilus
influenzae)
PF02348
(CTP_transf_3)
5 LEU A 116
ALA A 117
ASN A  91
VAL A  95
ALA A 190
None
1.03A 4x20B-1vicA:
undetectable
4x20B-1vicA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vma CELL DIVISION
PROTEIN FTSY


(Thermotoga
maritima)
PF00448
(SRP54)
PF02881
(SRP54_N)
5 LEU A 216
LEU A 244
THR A 221
ALA A 230
ILE A 255
None
0.89A 4x20B-1vmaA:
3.7
4x20B-1vmaA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA


(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
5 LEU A 517
LEU A 511
ALA A 495
THR A 609
ALA A 611
None
0.96A 4x20B-1w99A:
undetectable
4x20B-1w99A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA


(Mycobacterium
tuberculosis)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
5 LEU A 105
ALA A 109
LEU A 150
THR A 158
VAL A 133
None
1.01A 4x20B-1zj9A:
1.6
4x20B-1zj9A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zkl HIGH-AFFINITY
CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 7A


(Homo sapiens)
PF00233
(PDEase_I)
5 LEU A 298
LEU A 292
LEU A 198
ALA A 250
ALA A 289
None
0.97A 4x20B-1zklA:
undetectable
4x20B-1zklA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zu4 FTSY

(Mycoplasma
mycoides)
PF00448
(SRP54)
PF02881
(SRP54_N)
5 LEU A 324
LEU A 352
THR A 329
ALA A 338
ILE A 363
None
1.01A 4x20B-1zu4A:
3.7
4x20B-1zu4A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR SMALL
SUBUNIT


(Klebsiella
oxytoca)
PF02288
(Dehydratase_MU)
5 ALA B  54
THR B  98
ALA B 102
VAL B 106
ILE B  29
None
0.95A 4x20B-2d0oB:
undetectable
4x20B-2d0oB:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpw HYPOTHETICAL PROTEIN
TTHA0179


(Thermus
thermophilus)
PF12804
(NTP_transf_3)
5 LEU A  97
ALA A  41
ALA A   5
VAL A   7
ALA A  90
None
1.02A 4x20B-2dpwA:
undetectable
4x20B-2dpwA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fy2 CHOLINE
O-ACETYLTRANSFERASE


(Homo sapiens)
PF00755
(Carn_acyltransf)
5 LEU A 428
LEU A 421
ALA A 424
ALA A 562
ILE A 394
None
1.05A 4x20B-2fy2A:
undetectable
4x20B-2fy2A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6e D-ARABINOSE
1-DEHYDROGENASE


(Sulfolobus
solfataricus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 ALA A 226
ASN A 177
VAL A 173
ALA A 239
ILE A 199
None
0.98A 4x20B-2h6eA:
3.8
4x20B-2h6eA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hne L-FUCONATE
DEHYDRATASE


(Xanthomonas
campestris)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
6 LEU A 153
ALA A 156
LEU A 313
THR A 303
ALA A 336
ILE A 321
None
1.48A 4x20B-2hneA:
2.5
4x20B-2hneA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0o SER/THR PHOSPHATASE

(Anopheles
gambiae)
PF00481
(PP2C)
5 CYH A 428
LEU A 515
VAL A 420
ALA A 411
ILE A 504
None
0.91A 4x20B-2i0oA:
undetectable
4x20B-2i0oA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m1x TIR
DOMAIN-CONTAINING
ADAPTER MOLECULE 1


(Homo sapiens)
no annotation 5 LEU A 533
LEU A 416
THR A 426
ALA A 450
ILE A 453
None
0.96A 4x20B-2m1xA:
undetectable
4x20B-2m1xA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nc8 LIPOPROTEIN LPPM

(Mycobacterium
tuberculosis)
no annotation 5 LEU A 164
ALA A 125
ALA A  30
VAL A  28
ILE A  44
None
0.99A 4x20B-2nc8A:
undetectable
4x20B-2nc8A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2z HYPOTHETICAL PROTEIN

(Bacillus
halodurans)
PF01933
(UPF0052)
6 LEU A  19
ALA A  63
LEU A  61
VAL A  33
ALA A  31
ILE A 109
None
1.25A 4x20B-2o2zA:
4.8
4x20B-2o2zA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o78 PUTATIVE HISTIDINE
AMMONIA-LYASE


(Rhodobacter
sphaeroides)
PF00221
(Lyase_aromatic)
5 CYH A 466
LEU A 467
ALA A 411
ALA A 407
ILE A 459
None
0.89A 4x20B-2o78A:
undetectable
4x20B-2o78A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU


(Escherichia
coli)
PF00132
(Hexapep)
PF12804
(NTP_transf_3)
5 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
None
0.97A 4x20B-2oi6A:
undetectable
4x20B-2oi6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU


(Escherichia
coli)
PF00132
(Hexapep)
PF12804
(NTP_transf_3)
5 LEU A 367
ALA A 353
ALA A 342
VAL A 344
ALA A 361
None
0.88A 4x20B-2oi6A:
undetectable
4x20B-2oi6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pan GLYOXYLATE
CARBOLIGASE


(Escherichia
coli)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 LEU A 222
LEU A 329
VAL A 214
ALA A 219
ILE A 301
None
0.93A 4x20B-2panA:
undetectable
4x20B-2panA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qo3 ERYAII ERYTHROMYCIN
POLYKETIDE SYNTHASE
MODULES 3 AND 4


(Saccharopolyspora
erythraea)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 ALA A 208
LEU A 151
THR A 127
ALA A 224
ILE A 185
None
0.90A 4x20B-2qo3A:
undetectable
4x20B-2qo3A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsj DNA-BINDING RESPONSE
REGULATOR, LUXR
FAMILY


(Ruegeria
pomeroyi)
PF00072
(Response_reg)
5 ALA A  41
LEU A  43
ASN A  47
ALA A  33
ILE A  52
None
1.02A 4x20B-2qsjA:
4.4
4x20B-2qsjA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsj DNA-BINDING RESPONSE
REGULATOR, LUXR
FAMILY


(Ruegeria
pomeroyi)
PF00072
(Response_reg)
5 ALA A  41
LEU A  43
ASN A  47
VAL A   7
ALA A  33
None
0.90A 4x20B-2qsjA:
4.4
4x20B-2qsjA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfa TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6


(Mus musculus)
PF12796
(Ank_2)
PF13637
(Ank_4)
5 LEU A 137
LEU A 132
ALA A 120
VAL A 106
ALA A 141
None
0.93A 4x20B-2rfaA:
undetectable
4x20B-2rfaA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa)
PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc)
5 LEU A1022
ALA A1034
LEU A1032
ALA A1094
ILE A1059
None
1.05A 4x20B-2vz9A:
undetectable
4x20B-2vz9A:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wa0 MELANOMA-ASSOCIATED
ANTIGEN 4


(Homo sapiens)
PF01454
(MAGE)
5 LEU A 203
ALA A 278
LEU A 257
ALA A 211
ILE A 222
None
1.02A 4x20B-2wa0A:
undetectable
4x20B-2wa0A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyx BETA-LACTAMSE TOHO-1

(Escherichia
coli)
PF13354
(Beta-lactamase2)
5 LEU A 119
ASN A 136
ALA A 109
ALA A 125
ILE A  97
None
1.04A 4x20B-2wyxA:
undetectable
4x20B-2wyxA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE


(Amycolatopsis
orientalis)
PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N)
5 LEU A 292
LEU A 295
ALA A 245
VAL A 269
ALA A 270
None
1.03A 4x20B-2x05A:
undetectable
4x20B-2x05A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5r HYPOTHETICAL PROTEIN
ORF126


(Pyrobaculum
spherical virus)
no annotation 5 LEU A  61
ALA A  65
ASN A 100
ALA A  97
VAL A  41
None
1.03A 4x20B-2x5rA:
undetectable
4x20B-2x5rA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yn2 UNCHARACTERIZED
PROTEIN YNL108C


(Saccharomyces
cerevisiae)
PF00300
(His_Phos_1)
5 LEU A  47
ALA A  48
THR A 162
VAL A 166
ALA A   9
None
1.02A 4x20B-2yn2A:
undetectable
4x20B-2yn2A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron)
PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C)
6 LEU A 185
ALA A 222
LEU A 220
VAL A 197
ALA A 152
ILE A 207
None
1.06A 4x20B-3a24A:
undetectable
4x20B-3a24A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcz PROTEIN MEMO1

(Homo sapiens)
PF01875
(Memo)
5 LEU A 177
ALA A 255
LEU A 253
ALA A  44
ILE A 224
None
1.04A 4x20B-3bczA:
undetectable
4x20B-3bczA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes)
PF12799
(LRR_4)
5 LEU A 374
ASN A 378
ALA A 358
ALA A 333
ILE A 360
None
1.00A 4x20B-3bz5A:
undetectable
4x20B-3bz5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c10 HISTONE DEACETYLASE
7A


(Homo sapiens)
PF00850
(Hist_deacetyl)
5 LEU A 839
LEU A 837
ALA A 798
ALA A 854
VAL A 856
None
1.00A 4x20B-3c10A:
undetectable
4x20B-3c10A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk5 3-OXOACYL-SYNTHASE
III


(Xanthomonas
oryzae)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 LEU A 137
ALA A  76
VAL A 198
ALA A 201
ILE A  78
None
0.91A 4x20B-3fk5A:
undetectable
4x20B-3fk5A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fww BIFUNCTIONAL PROTEIN
GLMU


(Yersinia pestis)
PF00132
(Hexapep)
PF12804
(NTP_transf_3)
5 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
None
1.02A 4x20B-3fwwA:
undetectable
4x20B-3fwwA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fww BIFUNCTIONAL PROTEIN
GLMU


(Yersinia pestis)
PF00132
(Hexapep)
PF12804
(NTP_transf_3)
5 LEU A 367
ALA A 353
ALA A 342
VAL A 344
ALA A 361
None
1.01A 4x20B-3fwwA:
undetectable
4x20B-3fwwA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g40 NA-K-CL
COTRANSPORTER


(Methanosarcina
acetivorans)
no annotation 5 LEU A 757
ALA A 695
LEU A 691
ALA A 658
ILE A 635
None
1.02A 4x20B-3g40A:
undetectable
4x20B-3g40A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN


(Novosphingobium
aromaticivorans)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 CYH A 245
LEU A 246
THR A 181
VAL A 163
ILE A 156
None
1.02A 4x20B-3gazA:
undetectable
4x20B-3gazA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i99 UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE


(Vibrio cholerae)
PF01565
(FAD_binding_4)
PF02873
(MurB_C)
5 LEU A 302
LEU A 286
LEU A 334
ALA A 284
ILE A 332
PO4  A 359 (-4.6A)
None
None
None
None
1.00A 4x20B-3i99A:
undetectable
4x20B-3i99A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ib6 UNCHARACTERIZED
PROTEIN


(Listeria
monocytogenes)
PF13419
(HAD_2)
5 ALA A 108
LEU A 106
ALA A 116
ALA A  53
ILE A 135
None
0.96A 4x20B-3ib6A:
4.1
4x20B-3ib6A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1j ATP-DEPENDENT
PROTEASE LON


(Thermococcus
onnurineus)
PF01078
(Mg_chelatase)
PF05362
(Lon_C)
PF13654
(AAA_32)
5 LEU A 208
ALA A 261
LEU A 258
ALA A 237
ILE A 244
None
0.85A 4x20B-3k1jA:
undetectable
4x20B-3k1jA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdu N-FORMIMINO-L-GLUTAM
ATE IMINOHYDROLASE


(Pseudomonas
aeruginosa)
PF01979
(Amidohydro_1)
5 LEU A 290
LEU A 267
ALA A 270
ALA A 282
ALA A 286
None
0.82A 4x20B-3mduA:
undetectable
4x20B-3mduA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2m POSSIBLE HYDROLASE

(Mycobacterium
tuberculosis)
PF12697
(Abhydrolase_6)
5 LEU A 109
ALA A 144
ALA A  69
VAL A  67
ALA A  74
None
0.95A 4x20B-3p2mA:
3.9
4x20B-3p2mA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl2 SUGAR KINASE,
RIBOKINASE FAMILY


(Corynebacterium
glutamicum)
PF00294
(PfkB)
5 CYH A 205
LEU A 171
ALA A 208
ALA A 229
VAL A 231
None
1.04A 4x20B-3pl2A:
undetectable
4x20B-3pl2A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN


(Salmonella
enterica)
PF00291
(PALP)
5 LEU B 271
ALA B 284
THR B 199
ALA B 191
ILE B 238
None
1.02A 4x20B-3pr2B:
2.4
4x20B-3pr2B:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twd BIFUNCTIONAL PROTEIN
GLMU


(Escherichia
coli)
PF00132
(Hexapep)
5 LEU A 338
ALA A 336
ALA A 361
ALA A 342
ILE A 378
None
0.91A 4x20B-3twdA:
undetectable
4x20B-3twdA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twd BIFUNCTIONAL PROTEIN
GLMU


(Escherichia
coli)
PF00132
(Hexapep)
5 LEU A 338
LEU A 367
ALA A 361
ALA A 342
ILE A 378
None
0.93A 4x20B-3twdA:
undetectable
4x20B-3twdA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twd BIFUNCTIONAL PROTEIN
GLMU


(Escherichia
coli)
PF00132
(Hexapep)
5 LEU A 367
ALA A 353
ALA A 342
VAL A 344
ALA A 361
None
0.93A 4x20B-3twdA:
undetectable
4x20B-3twdA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuz PROTEIN SHQ1

(Saccharomyces
cerevisiae)
PF04925
(SHQ1)
5 LEU A 399
LEU A 303
THR A 371
ALA A 391
ILE A 369
None
0.98A 4x20B-3zuzA:
undetectable
4x20B-3zuzA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akm LYSOSOME-ASSOCIATED
MEMBRANE
GLYCOPROTEIN 3


(Homo sapiens)
PF01299
(Lamp)
5 LEU A 360
LEU A 292
ASN A 291
ALA A 270
ILE A 244
None
None
NAG  A1379 (-2.0A)
None
None
1.00A 4x20B-4akmA:
undetectable
4x20B-4akmA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE


(Thermotoga
maritima)
PF13597
(NRDD)
5 LEU A  83
VAL A 408
LYS A 403
ALA A 407
ILE A 372
None
0.99A 4x20B-4conA:
undetectable
4x20B-4conA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e3w ACID PHOSPHATASE

(Francisella
tularensis)
PF00328
(His_Phos_2)
5 ALA A  29
LEU A 170
THR A 182
ALA A 190
ILE A 209
None
0.87A 4x20B-4e3wA:
undetectable
4x20B-4e3wA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0l AMIDOHYDROLASE

(Brucella
abortus)
PF01979
(Amidohydro_1)
5 LEU A 295
LEU A 272
ALA A 275
ALA A 287
ALA A 291
None
0.93A 4x20B-4f0lA:
undetectable
4x20B-4f0lA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE


(Homo sapiens)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63)
6 LEU B 500
LEU B 488
LEU B 651
ALA B 513
ALA B 492
ILE B 613
None
1.25A 4x20B-4f92B:
undetectable
4x20B-4f92B:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmt CHPT PROTEIN

(Caulobacter
vibrioides)
PF10090
(HPTransfase)
5 LEU A 112
ALA A 101
ALA A 161
ALA A 146
ILE A 219
None
0.97A 4x20B-4fmtA:
undetectable
4x20B-4fmtA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hum MULTIDRUG EFFLUX
PROTEIN


(Neisseria
gonorrhoeae)
PF01554
(MatE)
6 LEU A  84
LEU A 163
ALA A  82
ALA A  76
ALA A 160
ILE A 250
None
1.16A 4x20B-4humA:
undetectable
4x20B-4humA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifr 2-AMINO-3-CARBOXYMUC
ONATE 6-SEMIALDEHYDE
DECARBOXYLASE


(Pseudomonas
fluorescens)
PF04909
(Amidohydro_2)
6 LEU A 126
ALA A 162
ALA A 133
LYS A 131
ALA A 129
ILE A 172
None
1.47A 4x20B-4ifrA:
undetectable
4x20B-4ifrA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhq CAMELID NANOBODY

(Vicugna pacos)
PF07686
(V-set)
5 CYH B  22
LEU B   4
ALA B  24
ASN B  32
ILE B  51
None
0.73A 4x20B-4lhqB:
undetectable
4x20B-4lhqB:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojz PUTATIVE ALGINATE
LYASE


(Saccharophagus
degradans)
PF05426
(Alginate_lyase)
PF07940
(Hepar_II_III)
5 LEU A 327
THR A 352
VAL A 362
LYS A 357
ALA A 361
None
1.05A 4x20B-4ojzA:
undetectable
4x20B-4ojzA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojz PUTATIVE ALGINATE
LYASE


(Saccharophagus
degradans)
PF05426
(Alginate_lyase)
PF07940
(Hepar_II_III)
5 THR A 352
VAL A 362
LYS A 357
ALA A 361
ILE A 349
None
1.03A 4x20B-4ojzA:
undetectable
4x20B-4ojzA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhr ALANINE RACEMASE

(Acinetobacter
baumannii)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
5 ALA A  48
LEU A  17
ASN A  16
VAL A  33
ALA A  37
None
None
None
LLP  A  34 ( 3.3A)
None
0.99A 4x20B-4qhrA:
undetectable
4x20B-4qhrA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnh MOTILITY REGULATOR

(Pseudomonas
aeruginosa)
PF00563
(EAL)
PF00990
(GGDEF)
5 LEU A 986
LEU A1063
VAL A1039
ALA A1040
ILE A1085
None
0.95A 4x20B-4rnhA:
undetectable
4x20B-4rnhA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE


(Homo sapiens)
PF00365
(PFK)
5 LEU A 636
LEU A 556
ALA A 597
ALA A 600
ILE A 320
None
1.02A 4x20B-4u1rA:
undetectable
4x20B-4u1rA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9p UPF0264 PROTEIN
MJ1099


(Methanocaldococcus
jannaschii)
PF04476
(4HFCP_synth)
5 LEU A  34
ALA A 184
VAL A 118
ALA A 120
ILE A 204
None
1.00A 4x20B-4u9pA:
undetectable
4x20B-4u9pA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v0p MELANOMA-ASSOCIATED
ANTIGEN 3


(Homo sapiens)
PF01454
(MAGE)
5 LEU A 202
ALA A 277
LEU A 256
ALA A 210
ILE A 221
None
1.01A 4x20B-4v0pA:
undetectable
4x20B-4v0pA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2i ESTERASE/LIPASE

(Thalassospira
sp. GB04J01)
PF07859
(Abhydrolase_3)
5 LEU A 314
ALA A 107
LEU A 103
ALA A 155
ALA A 181
None
1.00A 4x20B-4v2iA:
3.8
4x20B-4v2iA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjn NUCLEOCAPSID

(Mammalian
rubulavirus 5)
PF00973
(Paramyxo_ncap)
5 LEU A  73
THR A 178
ALA A 174
VAL A 170
ILE A 219
None
0.99A 4x20B-4xjnA:
undetectable
4x20B-4xjnA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpx ATP-DEPENDENT
PROTEASE LON


(Thermococcus
onnurineus)
PF01078
(Mg_chelatase)
PF13654
(AAA_32)
5 LEU A 208
ALA A 261
LEU A 258
ALA A 237
ILE A 244
None
0.85A 4x20B-4zpxA:
undetectable
4x20B-4zpxA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5isv RIBOSOMAL-PROTEIN-AL
ANINE
ACETYLTRANSFERASE


(Escherichia
coli)
PF00583
(Acetyltransf_1)
6 LEU A  45
ALA A  83
LEU A  85
THR A  57
VAL A  71
ALA A  53
None
1.42A 4x20B-5isvA:
undetectable
4x20B-5isvA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izn 50S RIBOSOMAL
PROTEIN L25


(Vibrio
vulnificus)
PF01386
(Ribosomal_L25p)
5 LEU A  19
ALA A  15
LEU A  11
ALA A  38
ALA A  40
None
1.04A 4x20B-5iznA:
undetectable
4x20B-5iznA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n3u PHYCOCYANOBILIN
LYASE SUBUNIT ALPHA


(Nostoc sp. PCC
7120)
no annotation 5 LEU A  84
ALA A  80
LEU A  41
ALA A  58
ILE A  23
None
0.99A 4x20B-5n3uA:
undetectable
4x20B-5n3uA:
11.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens)
no annotation 5 THR B 314
ALA B 316
VAL B 318
ALA B 354
ILE B 378
None
0.61A 4x20B-5n5nB:
53.6
4x20B-5n5nB:
97.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8p S-LAYER PROTEIN

(Caulobacter
vibrioides)
PF00353
(HemolysinCabind)
5 LEU A 930
THR A 985
VAL A 989
ALA A 976
ILE A1005
None
0.98A 4x20B-5n8pA:
undetectable
4x20B-5n8pA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n97 S-LAYER PROTEIN RSAA

(Caulobacter
vibrioides)
PF00353
(HemolysinCabind)
5 LEU A 930
THR A 985
VAL A 989
ALA A 976
ILE A1005
None
0.98A 4x20B-5n97A:
undetectable
4x20B-5n97A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjr METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE


(Pseudomonas sp.
AAC)
PF00171
(Aldedh)
5 LEU A 211
ALA A 143
LEU A 171
ASN A 199
ALA A 207
None
0.95A 4x20B-5tjrA:
undetectable
4x20B-5tjrA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvd TM16

(Trichuris muris)
PF01161
(PBP)
5 CYH A  29
LEU A  28
LEU A  56
ALA A  31
VAL A 126
None
0.89A 4x20B-5tvdA:
undetectable
4x20B-5tvdA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vst BILIARY GLYCOPROTEIN

(Mus musculus)
PF07686
(V-set)
PF13927
(Ig_3)
5 LEU A  20
THR A  98
ALA A 100
VAL A 102
ILE A  88
NAG  A 301 (-4.8A)
None
None
None
None
0.97A 4x20B-5vstA:
undetectable
4x20B-5vstA:
19.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae)
PF00091
(Tubulin)
PF03953
(Tubulin_C)
5 LEU B 253
ASN B 256
THR B 312
ALA B 314
ILE B 368
None
0.86A 4x20B-5w3jB:
53.5
4x20B-5w3jB:
75.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6


(Rattus
norvegicus)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4)
5 LEU A 136
ALA A 135
ASN A  92
ALA A  86
ALA A 120
LEU  A 136 ( 0.6A)
ALA  A 135 ( 0.0A)
ASN  A  92 ( 0.6A)
ALA  A  86 ( 0.0A)
ALA  A 120 ( 0.0A)
1.00A 4x20B-5wo6A:
undetectable
4x20B-5wo6A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wo6 TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6


(Rattus
norvegicus)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4)
5 LEU A 137
LEU A 132
ALA A 120
VAL A 106
ALA A 141
LEU  A 137 ( 0.6A)
LEU  A 132 ( 0.6A)
ALA  A 120 ( 0.0A)
VAL  A 106 ( 0.6A)
ALA  A 141 ( 0.0A)
0.99A 4x20B-5wo6A:
undetectable
4x20B-5wo6A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqw N-ACETYLGLUCOSAMINID
ASE


(Clostridium
perfringens)
PF01832
(Glucosaminidase)
5 CYH A 969
LEU A 970
LEU A1020
ALA A 954
ALA A1059
None
None
EDO  A1202 (-3.8A)
None
EDO  A1202 (-4.0A)
0.88A 4x20B-5wqwA:
undetectable
4x20B-5wqwA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5d MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1


(Caenorhabditis
elegans)
no annotation 5 LEU A 318
LEU A 349
ALA A 337
VAL A 335
ALA A 228
None
0.95A 4x20B-6b5dA:
undetectable
4x20B-6b5dA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44


(Homo sapiens)
no annotation 5 LEU K 551
ALA K 507
LEU K 558
VAL K 555
ILE K 459
None
1.04A 4x20B-6d6qK:
undetectable
4x20B-6d6qK:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esl BACTERIAL LEUCYL
AMINOPEPTIDASE


(Legionella
pneumophila)
no annotation 5 LEU A 300
ALA A 264
VAL A 266
ALA A 332
ILE A 189
None
0.93A 4x20B-6eslA:
3.3
4x20B-6eslA:
11.03