SIMILAR PATTERNS OF AMINO ACIDS FOR 4X1Y_D_LOCD502_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6h NEUTROPHIL CYTOSOL
FACTOR 4

(Homo sapiens) 		PF00787
(PX) 		5 LEU A 117
ASN A  25
LYS A  46
ALA A  21
ILE A  55
 None
 0.97A 4x1yD-1h6hA:
undetectable		 4x1yD-1h6hA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htd ATROLYSIN C

(Crotalus atrox) 		PF01421
(Reprolysin) 		5 LEU A  47
LEU A 148
ASN A 147
MET A 116
ILE A 198
 None
 0.99A 4x1yD-1htdA:
undetectable		 4x1yD-1htdA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixx COAGULATION FACTORS
IX/X-BINDING PROTEIN

(Protobothrops
flavoviridis) 		PF00059
(Lectin_C) 		5 ASN A  58
MET A  59
VAL A  40
LYS A  15
ILE A  66
 None
 1.04A 4x1yD-1ixxA:
undetectable		 4x1yD-1ixxA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1izo CYTOCHROME P450
152A1

(Bacillus
subtilis) 		PF00067
(p450) 		5 LEU A 241
LEU A 102
LEU A 214
ALA A 218
ILE A 198
 None
 1.01A 4x1yD-1izoA:
undetectable		 4x1yD-1izoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j1u TYROSYL-TRNA
SYNTHETASE

(Methanocaldococcus
jannaschii) 		PF00579
(tRNA-synt_1b) 		5 LEU A  24
LEU A  55
MET A  52
VAL A 189
ILE A 191
 None
 1.03A 4x1yD-1j1uA:
undetectable		 4x1yD-1j1uA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kug METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		5 CYH A  46
LEU A  49
LEU A 150
MET A 118
ILE A 199
 None
 1.06A 4x1yD-1kugA:
undetectable		 4x1yD-1kugA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lbz FRUCTOSE
1,6-BISPHOSPHATASE/I
NOSITOL
MONOPHOSPHATASE

(Archaeoglobus
fulgidus) 		PF00459
(Inositol_P) 		5 LEU A  81
ALA A  53
VAL A  17
ALA A  49
ILE A  13
 None
 1.05A 4x1yD-1lbzA:
undetectable		 4x1yD-1lbzA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A

(Thermobifida
fusca) 		PF00079
(Serpin) 		5 LEU A 145
THR A 298
ALA A 319
ALA A 317
ILE A 157
 None
 0.77A 4x1yD-1mtpA:
undetectable		 4x1yD-1mtpA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrw HYPOTHETICAL
PROTEIN, HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacillus
subtilis) 		PF08282
(Hydrolase_3) 		5 LEU A 285
MET A   1
ALA A 233
VAL A 235
ILE A   4
 None
 1.05A 4x1yD-1nrwA:
undetectable		 4x1yD-1nrwA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8d HYPOTHETICAL PROTEIN
(TT1679)

(Thermus
thermophilus) 		PF04260
(DUF436) 		5 LEU A  93
LEU A 100
LEU A  68
ALA A  51
ILE A 173
 None
 0.88A 4x1yD-1v8dA:
undetectable		 4x1yD-1v8dA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8d HYPOTHETICAL PROTEIN
(TT1679)

(Thermus
thermophilus) 		PF04260
(DUF436) 		5 LEU A 191
LEU A  55
MET A  60
LYS A 205
ALA A 203
 None
 1.07A 4x1yD-1v8dA:
undetectable		 4x1yD-1v8dA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG

(Mus musculus) 		PF00225
(Kinesin) 		6 MET A  81
ALA A 326
VAL A 328
LYS A   7
ALA A   9
ILE A  93
 None
 1.07A 4x1yD-1vfwA:
undetectable		 4x1yD-1vfwA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5t ORC2

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		6 LEU A 104
LEU A 129
ASN A 132
VAL A 142
ALA A  90
ILE A 180
 None
 1.31A 4x1yD-1w5tA:
undetectable		 4x1yD-1w5tA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wni TRIMERELYSIN II

(Protobothrops
flavoviridis) 		PF01421
(Reprolysin) 		5 LEU A  47
LEU A 148
ASN A 147
MET A 116
ILE A 197
 None
 1.03A 4x1yD-1wniA:
undetectable		 4x1yD-1wniA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp1 FII

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		5 LEU A  47
LEU A 148
ASN A 147
MET A 116
ILE A 197
 None
 0.93A 4x1yD-1yp1A:
undetectable		 4x1yD-1yp1A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9d URIDYLATE KINASE

(Streptococcus
pyogenes) 		PF00696
(AA_kinase) 		5 LEU A  11
LEU A  51
MET A  89
ALA A 162
ILE A  39
 None
 1.05A 4x1yD-1z9dA:
undetectable		 4x1yD-1z9dA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 LEU A 410
LEU A 436
ASN A 437
LYS A 441
ILE A 397
 None
 0.90A 4x1yD-2bucA:
2.8		 4x1yD-2bucA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t 3-KETOACYL-COA
THIOLASE
FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00108
(Thiolase_N)
PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
PF02803
(Thiolase_C) 		5 LEU C 142
LEU A 223
ASN A 264
ALA A 233
ILE A 259
 None
 1.04A 4x1yD-2d3tC:
undetectable		 4x1yD-2d3tC:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyk GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1) 		5 LEU A  17
LEU A  84
VAL A  44
LYS A   3
ILE A 156
 None
 1.06A 4x1yD-2dykA:
5.1		 4x1yD-2dykA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B

(Homo sapiens) 		PF14580
(LRR_9) 		5 LEU A 113
LEU A 122
LEU A 102
ASN A 101
ILE A  83
 None
 1.01A 4x1yD-2ellA:
undetectable		 4x1yD-2ellA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epg HYPOTHETICAL PROTEIN
TTHA1785

(Thermus
thermophilus) 		PF01139
(RtcB) 		5 LEU A 371
LEU A 468
LEU A 323
VAL A 465
ALA A 466
 None
 0.98A 4x1yD-2epgA:
undetectable		 4x1yD-2epgA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		5 LEU A 185
LEU A 292
MET A 295
ALA A 282
ILE A 278
 None
 0.96A 4x1yD-2fj0A:
2.6		 4x1yD-2fj0A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 ASN A 160
THR A 393
VAL A 220
ALA A 170
ILE A 228
 None
 1.08A 4x1yD-2gepA:
undetectable		 4x1yD-2gepA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m1x TIR
DOMAIN-CONTAINING
ADAPTER MOLECULE 1

(Homo sapiens) 		no annotation 5 LEU A 533
LEU A 416
THR A 426
ALA A 450
ILE A 453
 None
 0.92A 4x1yD-2m1xA:
undetectable		 4x1yD-2m1xA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsj DNA-BINDING RESPONSE
REGULATOR, LUXR
FAMILY

(Ruegeria
pomeroyi) 		PF00072
(Response_reg) 		5 LEU A  43
ASN A  47
VAL A   7
ALA A  33
ILE A  52
 None
 0.84A 4x1yD-2qsjA:
4.8		 4x1yD-2qsjA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Paraburkholderia
phytofirmans) 		PF13407
(Peripla_BP_4) 		5 LEU A 149
LEU A 348
VAL A 146
ALA A 147
ILE A 307
 None
 0.88A 4x1yD-2rjoA:
3.4		 4x1yD-2rjoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9v SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR

(Moorella
thermoacetica) 		PF09105
(SelB-wing_1)
PF09106
(SelB-wing_2) 		5 LEU A 432
LEU A 414
MET A 417
ALA A 400
ILE A 387
 None
 1.01A 4x1yD-2v9vA:
undetectable		 4x1yD-2v9vA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		5 LEU A 315
MET A 318
VAL A 675
ALA A 674
ILE A 366
 None
 1.04A 4x1yD-2xsgA:
undetectable		 4x1yD-2xsgA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		5 LEU A 185
LEU A 220
VAL A 197
ALA A 152
ILE A 207
 None
 0.66A 4x1yD-3a24A:
undetectable		 4x1yD-3a24A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 377
LEU A 395
LEU A 350
ALA A 341
ILE A 339
 None
 1.02A 4x1yD-3b2dA:
undetectable		 4x1yD-3b2dA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		5 LEU A 374
ASN A 378
ALA A 358
ALA A 333
ILE A 360
 None
 1.03A 4x1yD-3bz5A:
undetectable		 4x1yD-3bz5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfa CALCIUM-DEPENDENT
PROTEIN KINASE
CGD3_920

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 CYH A 257
LEU A 258
LEU A 239
ALA A 191
VAL A 188
 None
 1.01A 4x1yD-3dfaA:
undetectable		 4x1yD-3dfaA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr2 EXPORTED
GLUCONOLACTONASE

(Xanthomonas
campestris) 		PF08450
(SGL) 		5 CYH A 261
LEU A 252
ALA A 234
VAL A 236
ILE A 217
 None
 1.03A 4x1yD-3dr2A:
undetectable		 4x1yD-3dr2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsl ZINC
METALLOPROTEINASE-DI
SINTEGRIN
BOTHROPASIN

(Bothrops
jararaca) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		6 LEU A  50
LEU A 151
ASN A 150
MET A 119
ALA A  54
ILE A 201
 None
 1.14A 4x1yD-3dslA:
undetectable		 4x1yD-3dslA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8p UNCHARACTERIZED
PROTEIN

(Shewanella
oneidensis) 		PF03061
(4HBT) 		5 LEU A 105
LEU A  83
ALA A  24
VAL A  26
ILE A  41
 None
 1.07A 4x1yD-3e8pA:
undetectable		 4x1yD-3e8pA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdu PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE

(Acinetobacter
baumannii) 		PF00378
(ECH_1) 		5 LEU A  47
LEU A  22
LEU A  61
ALA A  15
ILE A  26
 None
 0.95A 4x1yD-3fduA:
undetectable		 4x1yD-3fduA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbo ZINC
METALLOPROTEINASE
BMOOMPALFA-I

(Bothrops
moojeni) 		PF01421
(Reprolysin) 		5 LEU A 146
ASN A 145
MET A 114
ALA A  49
ILE A 196
 None
 1.01A 4x1yD-3gboA:
undetectable		 4x1yD-3gboA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 CYH A 326
LEU A 327
LEU A 308
ALA A 260
VAL A 257
 None
 1.05A 4x1yD-3igoA:
undetectable		 4x1yD-3igoA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k53 FERROUS IRON
TRANSPORT PROTEIN B

(Pyrococcus
furiosus) 		PF02421
(FeoB_N) 		5 ASN A  81
THR A   5
ALA A   7
VAL A   9
ILE A  85
 None
 0.93A 4x1yD-3k53A:
2.9		 4x1yD-3k53A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7o LYMPHOCYTE ANTIGEN
86

(Mus musculus) 		PF02221
(E1_DerP2_DerF2) 		5 LEU A  53
LEU A 142
ALA A 157
VAL A  40
ALA A  32
 None
L9R  A 301 (-4.0A)
None
None
None
 1.01A 4x1yD-3m7oA:
undetectable		 4x1yD-3m7oA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 377
LEU A 395
LEU A 350
ALA A 341
ILE A 339
 None
 1.04A 4x1yD-3rg1A:
undetectable		 4x1yD-3rg1A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rnr STAGE II SPORULATION
E FAMILY PROTEIN

(Thermanaerovibrio
acidaminovorans) 		PF07228
(SpoIIE) 		5 LEU A  37
THR A 202
ALA A 204
VAL A 206
ALA A 176
 None
 0.79A 4x1yD-3rnrA:
undetectable		 4x1yD-3rnrA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF00982
(Glyco_transf_20) 		5 LEU A 313
LEU A 375
ALA A 432
ALA A 307
ILE A 403
 None
 1.07A 4x1yD-3t5tA:
5.5		 4x1yD-3t5tA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		5 LEU A 377
LEU A 395
LEU A 350
ALA A 341
ILE A 339
 None
 1.01A 4x1yD-3t6qA:
undetectable		 4x1yD-3t6qA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfw PUTATIVE
O-METHYLTRANSFERASE

(Klebsiella
pneumoniae) 		PF01596
(Methyltransf_3) 		5 LEU A 151
THR A 218
ALA A 220
VAL A 222
ILE A 164
 None
 1.02A 4x1yD-3tfwA:
3.3		 4x1yD-3tfwA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A

(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 LEU A 309
LEU A 337
THR A 327
ALA A 325
VAL A 323
 LEU  A 309 ( 0.6A)
LEU  A 337 ( 0.6A)
THR  A 327 ( 0.8A)
ALA  A 325 ( 0.0A)
VAL  A 323 ( 0.6A)
 1.04A 4x1yD-3whlA:
undetectable		 4x1yD-3whlA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwe OXIDIZED POLYVINYL
ALCOHOL HYDROLASE

(Pseudomonas sp.
VM15C) 		no annotation 5 LEU A  74
ASN A  82
ALA A  94
VAL A  96
ILE A  46
 None
 1.03A 4x1yD-3wweA:
5.0		 4x1yD-3wweA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfc CHROMOSOME-ASSOCIATE
D KINESIN KIF4

(Mus musculus) 		PF00225
(Kinesin) 		5 CYH A 191
LEU A 192
LEU A 152
VAL A 182
ILE A 219
 None
 0.93A 4x1yD-3zfcA:
undetectable		 4x1yD-3zfcA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akm LYSOSOME-ASSOCIATED
MEMBRANE
GLYCOPROTEIN 3

(Homo sapiens) 		PF01299
(Lamp) 		5 LEU A 360
LEU A 292
ASN A 291
ALA A 270
ILE A 244
 None
None
NAG  A1379 (-2.0A)
None
None
 1.02A 4x1yD-4akmA:
undetectable		 4x1yD-4akmA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE

(Thermotoga
maritima) 		PF13597
(NRDD) 		5 LEU A  83
VAL A 408
LYS A 403
ALA A 407
ILE A 372
 None
 0.97A 4x1yD-4conA:
3.1		 4x1yD-4conA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE

(Pseudomonas
aeruginosa) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 LEU A 363
ALA A 386
VAL A 382
ALA A 403
ILE A 351
 None
 1.05A 4x1yD-4cvmA:
undetectable		 4x1yD-4cvmA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1j GLYCEROL KINASE

(Sinorhizobium
meliloti) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A  29
THR A  81
ALA A  85
ALA A  50
ILE A  86
 None
 1.04A 4x1yD-4e1jA:
undetectable		 4x1yD-4e1jA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecf ABC-TYPE PHOSPHATE
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Lactobacillus
brevis) 		PF12849
(PBP_like_2) 		5 LEU A  46
LEU A 239
THR A  61
VAL A  65
ALA A  37
 None
 0.92A 4x1yD-4ecfA:
undetectable		 4x1yD-4ecfA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		5 LEU A 250
ASN A 347
MET A 348
VAL A  26
ILE A  24
 None
 1.05A 4x1yD-4fidA:
5.6		 4x1yD-4fidA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT

(Escherichia
coli) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 ASN A 160
THR A 393
VAL A 220
ALA A 170
ILE A 228
 None
 1.06A 4x1yD-4g38A:
undetectable		 4x1yD-4g38A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4m ZINC-DEPENDENT
METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		5 LEU A  49
LEU A 150
ASN A 149
MET A 118
ILE A 199
 None
 1.02A 4x1yD-4j4mA:
undetectable		 4x1yD-4j4mA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knw N-ACYLNEURAMINATE-9-
PHOSPHATASE

(Homo sapiens) 		PF13419
(HAD_2) 		5 CYH A  98
LEU A 101
LEU A  94
ALA A  47
ILE A  34
 None
 1.00A 4x1yD-4knwA:
3.9		 4x1yD-4knwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0x CHLOROMUCONATE
CYCLOISOMERASE

(Rhodococcus
opacus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  74
THR A  52
ALA A  50
VAL A  36
ALA A  10
 None
 0.94A 4x1yD-4m0xA:
3.1		 4x1yD-4m0xA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhl INTERLEUKIN-11

(Homo sapiens) 		PF07400
(IL11) 		5 LEU A  78
LEU A  75
ASN A  71
ALA A 176
ILE A 177
 None
 1.07A 4x1yD-4mhlA:
undetectable		 4x1yD-4mhlA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf2 ORNITHINE
CARBAMOYLTRANSFERASE

(Bacillus
anthracis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ASN A 222
ALA A 159
VAL A 161
ALA A 185
ILE A 227
 None
 1.06A 4x1yD-4nf2A:
2.6		 4x1yD-4nf2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofw PROTEIN DJ-1 HOMOLOG
D

(Arabidopsis
thaliana) 		PF01965
(DJ-1_PfpI) 		5 LEU A 382
ALA A 277
VAL A 279
ALA A 310
ILE A 200
 None
 0.98A 4x1yD-4ofwA:
2.4		 4x1yD-4ofwA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6q MSX2-INTERACTING
PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		5 LEU A 501
LEU A 508
LEU A 454
ALA A 479
ILE A 469
 None
 1.02A 4x1yD-4p6qA:
undetectable		 4x1yD-4p6qA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Shewanella
benthica) 		PF00701
(DHDPS) 		5 LEU A 282
ALA A 289
LYS A 287
ALA A 285
ILE A 236
 None
 1.05A 4x1yD-4pfmA:
2.5		 4x1yD-4pfmA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5c LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 147
LEU A 192
ASN A 186
THR A 184
VAL A 199
 None
 1.06A 4x1yD-4r5cA:
undetectable		 4x1yD-4r5cA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6g LEUCINE RICH REPEATS
DLRR_K

(synthetic
construct) 		PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 203
LEU A 248
ASN A 242
THR A 240
VAL A 255
 None
 1.06A 4x1yD-4r6gA:
undetectable		 4x1yD-4r6gA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7z CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus) 		PF00493
(MCM) 		5 LEU A 325
LEU A 338
LEU A 761
MET A 764
ILE A 772
 None
 1.05A 4x1yD-4r7zA:
undetectable		 4x1yD-4r7zA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnh MOTILITY REGULATOR

(Pseudomonas
aeruginosa) 		PF00563
(EAL)
PF00990
(GGDEF) 		5 LEU A 986
LEU A1063
VAL A1039
ALA A1040
ILE A1085
 None
 0.93A 4x1yD-4rnhA:
undetectable		 4x1yD-4rnhA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u48 PUTATIVE INNER
MEMBRANE LIPOPROTEIN

(Salmonella
enterica) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
PF11974
(MG1) 		5 LEU A 853
LEU A 969
VAL A 888
ALA A 992
ILE A 967
 None
 0.99A 4x1yD-4u48A:
undetectable		 4x1yD-4u48A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usp CCL2 LECTIN

(Coprinopsis
cinerea) 		no annotation 5 LEU A  20
LEU A  44
THR A  30
VAL A 138
ILE A  14
 None
 1.06A 4x1yD-4uspA:
undetectable		 4x1yD-4uspA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjn NUCLEOCAPSID

(Mammalian
rubulavirus 5) 		PF00973
(Paramyxo_ncap) 		5 LEU A  73
THR A 178
ALA A 174
VAL A 170
ILE A 219
 None
 1.00A 4x1yD-4xjnA:
undetectable		 4x1yD-4xjnA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		5 CYH A 399
ALA A 331
VAL A 379
ALA A 406
ILE A  64
 None
 1.02A 4x1yD-5a4jA:
4.4		 4x1yD-5a4jA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		5 LEU A 336
ALA A 331
VAL A 379
ALA A 406
ILE A  64
 None
 1.07A 4x1yD-5a4jA:
4.4		 4x1yD-5a4jA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		5 LEU A 298
LEU A 412
THR A 152
ALA A 123
VAL A 127
 None
 1.06A 4x1yD-5e78A:
undetectable		 4x1yD-5e78A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9a ADHESIN BINDING
FUCOSYLATED
HISTO-BLOOD GROUP
ANTIGEN,ADHESIN,ADHE
SIN BINDING
FUCOSYLATED
HISTO-BLOOD GROUP
ANTIGEN

(Helicobacter
pylori) 		no annotation 5 LEU A  73
LEU A 315
LEU A 362
ALA A  85
ILE A 434
 None
 1.06A 4x1yD-5f9aA:
undetectable		 4x1yD-5f9aA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 NICASTRIN

(Homo sapiens) 		PF05450
(Nicastrin) 		5 LEU A 312
LEU A 494
THR A 280
ALA A 278
VAL A 276
 None
 0.90A 4x1yD-5fn4A:
undetectable		 4x1yD-5fn4A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6o PORPHOBILINOGEN
DEAMINASE

(Vibrio cholerae) 		no annotation 5 LEU A 244
ASN A 241
MET A 240
ALA A 267
VAL A 278
 None
 1.07A 4x1yD-5h6oA:
undetectable		 4x1yD-5h6oA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jdd TITIN

(Homo sapiens) 		PF07679
(I-set) 		5 LEU A 260
LEU A 184
LEU A 234
MET A 225
ILE A 217
 None
 0.94A 4x1yD-5jddA:
undetectable		 4x1yD-5jddA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l56 PLEXIN-A1

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		5 LEU A 535
LEU A 590
ALA A 584
VAL A 562
ALA A 650
 None
 1.07A 4x1yD-5l56A:
undetectable		 4x1yD-5l56A:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA

(Escherichia
coli) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5) 		5 LEU A 208
LEU A 266
ALA A 234
ALA A 226
ILE A 271
 None
 1.07A 4x1yD-5lm7A:
undetectable		 4x1yD-5lm7A:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 LEU A 253
MET A 257
THR A 311
ALA A 313
ILE A 367
 None
 1.01A 4x1yD-5mjsA:
53.3		 4x1yD-5mjsA:
58.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 MET A 257
THR A 311
ALA A 313
ALA A 351
ILE A 367
 None
 0.61A 4x1yD-5mjsA:
53.3		 4x1yD-5mjsA:
58.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 6 LEU B 252
THR B 314
ALA B 316
VAL B 318
ALA B 354
ILE B 378
 None
 1.01A 4x1yD-5n5nB:
53.7		 4x1yD-5n5nB:
97.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 6 LEU B 255
ASN B 258
MET B 259
THR B 314
ALA B 316
ILE B 378
 None
 0.93A 4x1yD-5n5nB:
53.7		 4x1yD-5n5nB:
97.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 6 MET B 259
THR B 314
ALA B 316
VAL B 318
ALA B 354
ILE B 378
 None
 0.69A 4x1yD-5n5nB:
53.7		 4x1yD-5n5nB:
97.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8p S-LAYER PROTEIN

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		5 LEU A 930
THR A 985
VAL A 989
ALA A 976
ILE A1005
 None
 0.97A 4x1yD-5n8pA:
undetectable		 4x1yD-5n8pA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n97 S-LAYER PROTEIN RSAA

(Caulobacter
vibrioides) 		PF00353
(HemolysinCabind) 		5 LEU A 930
THR A 985
VAL A 989
ALA A 976
ILE A1005
 None
 0.97A 4x1yD-5n97A:
undetectable		 4x1yD-5n97A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t33 RHPA GP120 CORE

(Human
immunodeficiency
virus) 		PF00516
(GP120) 		5 LEU G 342
LEU G 452
LEU G 390
VAL G 292
ILE G 333
 None
 0.85A 4x1yD-5t33G:
undetectable		 4x1yD-5t33G:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		6 LEU A 217
LEU A 259
MET A 262
ALA A 236
VAL A 238
ILE A 265
 None
 1.38A 4x1yD-5tvjA:
undetectable		 4x1yD-5tvjA:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 LEU B 253
ASN B 256
THR B 312
ALA B 314
ILE B 368
 None
 0.72A 4x1yD-5w3jB:
53.6		 4x1yD-5w3jB:
75.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc1 MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1

(Caenorhabditis
elegans) 		PF00004
(AAA) 		5 LEU A 318
LEU A 349
THR A 339
VAL A 335
ALA A 228
 None
 0.96A 4x1yD-5wc1A:
undetectable		 4x1yD-5wc1A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc1 MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1

(Caenorhabditis
elegans) 		PF00004
(AAA) 		6 LEU A 318
THR A 339
ALA A 337
VAL A 335
ALA A 228
ILE A 291
 None
 1.17A 4x1yD-5wc1A:
undetectable		 4x1yD-5wc1A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S15A

(Trichomonas
vaginalis) 		PF00410
(Ribosomal_S8) 		5 LEU W  11
LEU W  69
LEU W  38
VAL W  25
ILE W  61
 None
 1.06A 4x1yD-5xyiW:
undetectable		 4x1yD-5xyiW:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5c KATANIN P60
ATPASE-CONTAINING
SUBUNIT A-LIKE 1

(Homo sapiens) 		no annotation 5 LEU A 333
LEU A 368
THR A 358
ALA A 356
VAL A 354
 None
 0.97A 4x1yD-6b5cA:
undetectable		 4x1yD-6b5cA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5d MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1

(Caenorhabditis
elegans) 		no annotation 5 LEU A 318
ALA A 337
VAL A 335
ALA A 228
ILE A 291
 None
 0.75A 4x1yD-6b5dA:
undetectable		 4x1yD-6b5dA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5d MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1

(Caenorhabditis
elegans) 		no annotation 5 THR A 339
ALA A 337
VAL A 335
ALA A 228
ILE A 291
 None
 0.90A 4x1yD-6b5dA:
undetectable		 4x1yD-6b5dA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf6 INSULIN-DEGRADING
ENZYME

(Homo sapiens) 		no annotation 6 LEU A 642
LEU A 616
LEU A 574
ASN A 573
LYS A 571
ILE A 733
 None
 1.28A 4x1yD-6bf6A:
undetectable		 4x1yD-6bf6A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT B

(Flavobacterium
johnsoniae) 		no annotation 5 LEU B 488
THR B 186
VAL B 182
ALA B 208
ILE B 405
 None
 1.05A 4x1yD-6btmB:
undetectable		 4x1yD-6btmB:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 10
N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT

(Homo sapiens) 		no annotation 5 LEU A 541
LEU B  11
ASN B  13
MET B  14
ALA B   6
 None
 0.99A 4x1yD-6c9mA:
undetectable		 4x1yD-6c9mA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esl BACTERIAL LEUCYL
AMINOPEPTIDASE

(Legionella
pneumophila) 		no annotation 5 LEU A 300
ALA A 264
VAL A 266
ALA A 332
ILE A 189
 None
 0.86A 4x1yD-6eslA:
undetectable		 4x1yD-6eslA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD

(Acetobacterium
woodii) 		no annotation 5 CYH B  74
LEU B  34
ASN B  40
VAL B  59
ALA B   7
 None
 0.85A 4x1yD-6fahB:
undetectable		 4x1yD-6fahB:
11.60