SIMILAR PATTERNS OF AMINO ACIDS FOR 4X1Y_B_LOCB502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1al8 GLYCOLATE OXIDASE

(Spinacia
oleracea) 		PF01070
(FMN_dh) 		5 LEU A 298
ALA A 297
MET A  74
THR A 101
ILE A  64
 None
 1.10A 4x1yB-1al8A:
2.7		 4x1yB-1al8A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bud PROTEIN (ACUTOLYSIN
A)

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		5 LEU A  47
LEU A 148
ASN A 147
MET A 116
ILE A 198
 None
 0.98A 4x1yB-1budA:
undetectable		 4x1yB-1budA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e32 P97

(Mus musculus) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2) 		5 LEU A 357
THR A 347
ALA A 345
VAL A 343
ILE A 303
 None
 0.96A 4x1yB-1e32A:
undetectable		 4x1yB-1e32A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htd ATROLYSIN C

(Crotalus atrox) 		PF01421
(Reprolysin) 		5 LEU A  47
LEU A 148
ASN A 147
MET A 116
ILE A 198
 None
 1.00A 4x1yB-1htdA:
undetectable		 4x1yB-1htdA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixx COAGULATION FACTORS
IX/X-BINDING PROTEIN

(Protobothrops
flavoviridis) 		PF00059
(Lectin_C) 		5 ASN A  58
MET A  59
VAL A  40
LYS A  15
ILE A  66
 None
 1.13A 4x1yB-1ixxA:
undetectable		 4x1yB-1ixxA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy2 ATP-DEPENDENT
METALLOPROTEASE FTSH

(Thermus
thermophilus) 		PF00004
(AAA) 		5 LEU A 283
LEU A 311
THR A 301
ALA A 299
VAL A 297
 None
 0.97A 4x1yB-1iy2A:
undetectable		 4x1yB-1iy2A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3v CAPSID PROTEIN VP2

(Ungulate
protoparvovirus
1) 		PF00740
(Parvo_coat) 		5 LEU A  86
ALA A 101
LEU A 218
ASN A 217
ILE A 230
 None
 0.92A 4x1yB-1k3vA:
undetectable		 4x1yB-1k3vA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhm S-ADENOSYLMETHIONINE
DECARBOXYLASE

(Solanum
tuberosum) 		PF01536
(SAM_decarbox) 		5 LEU A 140
LEU B  19
VAL A 110
LYS A  81
ILE A  99
 None
 0.98A 4x1yB-1mhmA:
undetectable		 4x1yB-1mhmA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)

(Thermoproteus
tenax) 		PF00171
(Aldedh) 		5 LEU A 409
LEU A 304
ALA A 412
ALA A 425
ILE A 447
 None
 1.13A 4x1yB-1uxtA:
undetectable		 4x1yB-1uxtA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9k RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE C

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		5 LEU A 137
LEU A 139
LEU A 127
LYS A 107
ILE A  95
 None
 1.08A 4x1yB-1v9kA:
undetectable		 4x1yB-1v9kA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		5 LEU A 517
LEU A 511
ALA A 495
THR A 609
ALA A 611
 None
 1.08A 4x1yB-1w99A:
undetectable		 4x1yB-1w99A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wni TRIMERELYSIN II

(Protobothrops
flavoviridis) 		PF01421
(Reprolysin) 		5 LEU A  47
LEU A 148
ASN A 147
MET A 116
ILE A 197
 None
 1.05A 4x1yB-1wniA:
undetectable		 4x1yB-1wniA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA

(Mycobacterium
tuberculosis) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 LEU A 105
ALA A 109
LEU A 150
THR A 158
VAL A 133
 None
 0.96A 4x1yB-1zj9A:
undetectable		 4x1yB-1zj9A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bg9 ACETYLCHOLINE
RECEPTOR PROTEIN,
BETA CHAIN

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 LEU B 259
LEU B 297
MET B 446
VAL B 238
ILE B 442
 None
 1.08A 4x1yB-2bg9B:
undetectable		 4x1yB-2bg9B:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 LEU A 410
LEU A 436
ASN A 437
LYS A 441
ILE A 397
 None
 1.06A 4x1yB-2bucA:
undetectable		 4x1yB-2bucA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhr FTSH

(Thermus
thermophilus) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		5 LEU A 283
LEU A 311
ALA A 299
VAL A 297
ILE A 257
 None
 1.10A 4x1yB-2dhrA:
undetectable		 4x1yB-2dhrA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyk GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1) 		5 LEU A  17
LEU A  84
VAL A  44
LYS A   3
ILE A 156
 None
 0.98A 4x1yB-2dykA:
3.7		 4x1yB-2dykA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fur HYPOTHETICAL PROTEIN

(Thermoplasma
acidophilum) 		PF12900
(Pyridox_ox_2) 		5 ALA A  26
LEU A  28
ASN A  31
ALA A 104
ILE A 106
 None
 1.13A 4x1yB-2furA:
undetectable		 4x1yB-2furA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		5 LEU A 258
LEU A 267
ALA A 256
ALA A 182
ILE A 188
 None
 1.12A 4x1yB-2gouA:
2.5		 4x1yB-2gouA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lvv FLAGELLAR
CALCIUM-BINDING
PROTEIN TB-24

(Trypanosoma
brucei) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		5 LEU A 150
LEU A 152
ASN A 177
ALA A 172
ILE A 169
 None
 1.17A 4x1yB-2lvvA:
undetectable		 4x1yB-2lvvA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nc8 LIPOPROTEIN LPPM

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 164
ALA A 125
ALA A  30
VAL A  28
ILE A  44
 None
 0.83A 4x1yB-2nc8A:
undetectable		 4x1yB-2nc8A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nc8 LIPOPROTEIN LPPM

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 164
ALA A 125
LEU A 110
ALA A  30
VAL A  28
 None
 1.04A 4x1yB-2nc8A:
undetectable		 4x1yB-2nc8A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2omv INTERNALIN-A

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		5 LEU A 160
LEU A 144
LEU A 149
MET A 127
ILE A 113
 None
 1.13A 4x1yB-2omvA:
undetectable		 4x1yB-2omvA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5t PEZT

(Streptococcus
pneumoniae) 		PF06414
(Zeta_toxin) 		5 LEU B 184
LEU B 227
ALA B 144
LEU B 142
ILE B 200
 None
 1.12A 4x1yB-2p5tB:
2.4		 4x1yB-2p5tB:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pr7 HALOACID
DEHALOGENASE/EPOXIDE
HYDROLASE FAMILY

(Corynebacterium
glutamicum) 		PF00702
(Hydrolase) 		5 LEU A  26
LEU A 132
ALA A  29
LEU A   4
VAL A 123
 None
 1.11A 4x1yB-2pr7A:
undetectable		 4x1yB-2pr7A:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rik TITIN

(Oryctolagus
cuniculus) 		PF07679
(I-set) 		5 CYH A  85
ALA A  87
THR A  51
ALA A  57
ILE A  33
 None
 1.15A 4x1yB-2rikA:
undetectable		 4x1yB-2rikA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5r HYPOTHETICAL PROTEIN
ORF126

(Pyrobaculum
spherical virus) 		no annotation 5 LEU A  61
ALA A  65
ASN A 100
ALA A  97
VAL A  41
 None
 0.94A 4x1yB-2x5rA:
undetectable		 4x1yB-2x5rA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr3 MYOSIN LIGHT CHAIN
KINASE, SMOOTH
MUSCLE

(Homo sapiens) 		PF07679
(I-set) 		5 CYH A  92
ALA A  94
THR A  58
ALA A  64
ILE A  43
 None
 1.11A 4x1yB-2yr3A:
undetectable		 4x1yB-2yr3A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyt OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Geobacillus
kaustophilus) 		PF00215
(OMPdecase) 		5 LEU A  78
ALA A  83
ASN A  87
ALA A 100
ILE A 101
 None
 1.10A 4x1yB-2yytA:
undetectable		 4x1yB-2yytA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aag GENERAL
GLYCOSYLATION
PATHWAY PROTEIN

(Campylobacter
jejuni) 		PF02516
(STT3) 		5 LEU A 491
ALA A 682
LEU A 562
LYS A 695
ILE A 560
 None
MLY  A 493 ( 3.6A)
None
MLY  A 694 ( 3.3A)
None
 1.11A 4x1yB-3aagA:
undetectable		 4x1yB-3aagA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr2 EXPORTED
GLUCONOLACTONASE

(Xanthomonas
campestris) 		PF08450
(SGL) 		5 CYH A 261
LEU A 252
ALA A 234
VAL A 236
ILE A 217
 None
 1.14A 4x1yB-3dr2A:
undetectable		 4x1yB-3dr2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsl ZINC
METALLOPROTEINASE-DI
SINTEGRIN
BOTHROPASIN

(Bothrops
jararaca) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		5 LEU A  50
LEU A 151
ASN A 150
MET A 119
ILE A 201
 None
 1.01A 4x1yB-3dslA:
undetectable		 4x1yB-3dslA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo7 PUTATIVE
NITROREDUCTASE

(Trichormus
variabilis) 		PF00881
(Nitroreductase) 		5 ALA A 351
LEU A 353
THR A 504
VAL A 388
ILE A 383
 None
 1.07A 4x1yB-3eo7A:
undetectable		 4x1yB-3eo7A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1x SERINE
ACETYLTRANSFERASE

(Bacteroides
vulgatus) 		PF00132
(Hexapep) 		5 LEU A 130
ASN A 162
THR A 189
ALA A 156
ILE A 205
 None
 1.08A 4x1yB-3f1xA:
undetectable		 4x1yB-3f1xA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgq NEUROSERPIN

(Homo sapiens) 		PF00079
(Serpin) 		5 LEU A 325
LEU A 125
LEU A 112
ASN A 137
ALA A 134
 None
 1.12A 4x1yB-3fgqA:
undetectable		 4x1yB-3fgqA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxi TOLL-LIKE RECEPTOR 4

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 258
LEU A 208
ASN A 213
MET A 215
ILE A 218
 None
 1.08A 4x1yB-3fxiA:
undetectable		 4x1yB-3fxiA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		5 LEU A  53
LEU A   7
ALA A  22
VAL A  20
ILE A 245
 None
 1.14A 4x1yB-3g5iA:
7.0		 4x1yB-3g5iA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gaz ALCOHOL
DEHYDROGENASE
SUPERFAMILY PROTEIN

(Novosphingobium
aromaticivorans) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 CYH A 245
LEU A 246
THR A 181
VAL A 163
ILE A 156
 None
 1.13A 4x1yB-3gazA:
3.6		 4x1yB-3gazA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1w MANNOSE-6-PHOSPHATE
ISOMERASE

(Salmonella
enterica) 		PF01238
(PMI_typeI) 		5 LEU A 235
LEU A 187
MET A 190
ALA A 198
VAL A 161
 None
EDO  A 394 ( 4.0A)
None
None
None
 1.14A 4x1yB-3h1wA:
undetectable		 4x1yB-3h1wA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 SMALL NUCLEAR
RIBONUCLEOPROTEIN SM
D2

(Schizosaccharomyces
pombe) 		PF01423
(LSM) 		5 LEU G 101
ASN G  65
MET G  66
VAL G 107
ILE G  45
 None
U  C 101 ( 3.2A)
None
None
None
 1.08A 4x1yB-3jb9G:
undetectable		 4x1yB-3jb9G:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF00465
(Fe-ADH) 		6 CYH A 222
LEU A 223
LEU A 202
ALA A 226
ASN A 173
VAL A 209
 None
None
None
None
NAD  A 400 ( 4.8A)
None
 1.34A 4x1yB-3jzdA:
3.0		 4x1yB-3jzdA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n08 PUTATIVE
PHOSPHATIDYLETHANOLA
MINE-BINDING PROTEIN
(PEBP)

(Chlamydia
trachomatis) 		PF01161
(PBP) 		5 LEU A 118
ALA A 132
LEU A 130
THR A 140
ILE A  44
 None
 1.12A 4x1yB-3n08A:
undetectable		 4x1yB-3n08A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A  -1
LEU A 309
ASN A 307
ALA A  15
ILE A 106
 None
 1.06A 4x1yB-3oc4A:
undetectable		 4x1yB-3oc4A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouh EGL NINE HOMOLOG 1

(Homo sapiens) 		PF13640
(2OG-FeII_Oxy_3) 		5 LEU A 271
THR A 257
ALA A 298
LYS A 297
ILE A 386
 None
 1.11A 4x1yB-3ouhA:
undetectable		 4x1yB-3ouhA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl2 SUGAR KINASE,
RIBOKINASE FAMILY

(Corynebacterium
glutamicum) 		PF00294
(PfkB) 		5 CYH A 205
LEU A 171
ALA A 208
ALA A 229
VAL A 231
 None
 0.97A 4x1yB-3pl2A:
4.6		 4x1yB-3pl2A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 525
LEU A 498
LEU A 503
THR A 459
ILE A 486
 None
 1.05A 4x1yB-3rg1A:
undetectable		 4x1yB-3rg1A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vas PUTATIVE ADENOSINE
KINASE

(Schistosoma
mansoni) 		PF00294
(PfkB) 		5 LEU A 107
LEU A 340
LEU A  67
ALA A  62
ILE A  98
 None
 1.07A 4x1yB-3vasA:
6.6		 4x1yB-3vasA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A

(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 LEU A 309
LEU A 337
ALA A 325
VAL A 323
ILE A 283
 LEU  A 309 ( 0.6A)
LEU  A 337 ( 0.6A)
ALA  A 325 ( 0.0A)
VAL  A 323 ( 0.6A)
ILE  A 283 ( 0.7A)
 1.17A 4x1yB-3whlA:
undetectable		 4x1yB-3whlA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A

(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 LEU A 309
LEU A 337
THR A 327
ALA A 325
VAL A 323
 LEU  A 309 ( 0.6A)
LEU  A 337 ( 0.6A)
THR  A 327 ( 0.8A)
ALA  A 325 ( 0.0A)
VAL  A 323 ( 0.6A)
 1.16A 4x1yB-3whlA:
undetectable		 4x1yB-3whlA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjs NADH OXIDASE

(Gluconobacter
oxydans) 		PF00724
(Oxidored_FMN) 		5 LEU A 249
LEU A 258
ALA A 247
ALA A 173
ILE A 179
 None
 1.16A 4x1yB-3wjsA:
undetectable		 4x1yB-3wjsA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3t DNA MISMATCH REPAIR
PROTEIN HSM3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 291
LEU A 314
ALA A 268
LEU A 264
ILE A 298
 None
 1.17A 4x1yB-4a3tA:
undetectable		 4x1yB-4a3tA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		5 LEU A  47
LEU A 148
ASN A 147
MET A 116
ILE A 198
 None
 0.97A 4x1yB-4aigA:
undetectable		 4x1yB-4aigA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boo ACETYLCHOLINE
RECEPTOR BETA
SUBUNIT

(Torpedo
marmorata) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 LEU B 259
LEU B 297
MET B 446
VAL B 238
ILE B 442
 None
 1.08A 4x1yB-4booB:
undetectable		 4x1yB-4booB:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		5 LEU A 250
ASN A 347
MET A 348
VAL A  26
ILE A  24
 None
 1.08A 4x1yB-4fidA:
2.1		 4x1yB-4fidA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4m ZINC-DEPENDENT
METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		5 LEU A  49
LEU A 150
ASN A 149
MET A 118
ILE A 199
 None
 1.06A 4x1yB-4j4mA:
undetectable		 4x1yB-4j4mA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb7 ACCESSORY
COLONIZATION FACTOR
ACFC

(Vibrio cholerae) 		PF13531
(SBP_bac_11) 		5 LEU A 239
ALA A  42
LEU A  28
ASN A  54
LYS A   0
 None
TRS  A 302 ( 4.3A)
None
TRS  A 302 (-4.5A)
None
 1.10A 4x1yB-4jb7A:
undetectable		 4x1yB-4jb7A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krt AUTOLYTIC LYSOZYME

(Clostridium
phage phiSM101) 		PF01183
(Glyco_hydro_25)
PF08239
(SH3_3) 		5 CYH A 117
LEU A 121
THR A 138
ALA A 141
ILE A 169
 None
 1.09A 4x1yB-4krtA:
undetectable		 4x1yB-4krtA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktp GLYCOSIDE HYDROLASE
FAMILY 65 CENTRAL
CATALYTIC

([Bacillus]
selenitireducens) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		5 LEU A 257
ALA A 260
THR A 159
ALA A  79
ILE A 161
 None
 1.16A 4x1yB-4ktpA:
undetectable		 4x1yB-4ktpA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhq CAMELID NANOBODY

(Vicugna pacos) 		PF07686
(V-set) 		5 CYH B  22
LEU B   4
ALA B  24
ASN B  32
ILE B  51
 None
 0.75A 4x1yB-4lhqB:
undetectable		 4x1yB-4lhqB:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m38 PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Trypanosoma
brucei) 		PF06325
(PrmA) 		5 CYH A 215
LEU A 218
ALA A 299
LEU A 301
VAL A 257
 None
 1.07A 4x1yB-4m38A:
2.4		 4x1yB-4m38A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9n STEROL UPTAKE
CONTROL PROTEIN 2,
LYSOZYME

(Escherichia
virus T4;
Saccharomyces
cerevisiae) 		PF00959
(Phage_lysozyme)
PF11951
(Fungal_trans_2) 		5 LEU A 683
LEU A 649
LEU A 705
THR A 659
ALA A 655
 None
 1.08A 4x1yB-4n9nA:
undetectable		 4x1yB-4n9nA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmn REPLICATIVE DNA
HELICASE

(Aquifex
aeolicus) 		PF00772
(DnaB)
PF03796
(DnaB_C) 		5 LEU A  18
LEU A  47
LEU A  52
ASN A  54
ILE A  68
 None
 1.18A 4x1yB-4nmnA:
undetectable		 4x1yB-4nmnA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 ALA A 359
THR A 644
ALA A 642
LYS A 633
ILE A 653
 None
 1.14A 4x1yB-4nsxA:
undetectable		 4x1yB-4nsxA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4o DNA POLYMERASE BETA

(Leishmania
infantum) 		PF10391
(DNA_pol_lambd_f)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb)
PF14792
(DNA_pol_B_palm) 		5 LEU A 248
LEU A 225
ALA A 197
VAL A 270
ILE A 181
 None
 1.08A 4x1yB-4p4oA:
undetectable		 4x1yB-4p4oA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po4 LAMPETRA PLANERI
VLRC

(Lampetra
planeri) 		PF13855
(LRR_8) 		5 LEU A  93
LEU A  66
LEU A  71
ALA A  59
ILE A  55
 None
 1.15A 4x1yB-4po4A:
undetectable		 4x1yB-4po4A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		5 CYH A1407
LEU A1415
LEU A1405
VAL A1353
ILE A1385
 None
 1.11A 4x1yB-4r04A:
undetectable		 4x1yB-4r04A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		5 LEU A1757
ALA A1348
LEU A1344
ASN A1343
ILE A1286
 None
 1.17A 4x1yB-4r7yA:
undetectable		 4x1yB-4r7yA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Pseudomonas
aeruginosa) 		PF01425
(Amidase) 		5 LEU A  70
ALA A  11
LEU A   7
MET A 224
ILE A  74
 None
 1.12A 4x1yB-4wj3A:
undetectable		 4x1yB-4wj3A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjn NUCLEOCAPSID

(Mammalian
rubulavirus 5) 		PF00973
(Paramyxo_ncap) 		5 LEU A  73
THR A 178
ALA A 174
VAL A 170
ILE A 219
 None
 1.01A 4x1yB-4xjnA:
undetectable		 4x1yB-4xjnA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z1p CELL WALL SURFACE
ANCHOR PROTEIN

(Streptococcus
agalactiae) 		PF16364
(Antigen_C) 		5 LEU A  59
ALA A  58
LEU A 170
ASN A 168
ALA A  22
 None
 1.10A 4x1yB-4z1pA:
undetectable		 4x1yB-4z1pA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z23 CELL WALL SURFACE
ANCHOR PROTEIN

(Streptococcus
agalactiae) 		PF16364
(Antigen_C) 		5 LEU A  59
ALA A  58
LEU A 170
ASN A 168
ALA A  22
 None
None
None
None
EDO  A 401 (-3.8A)
 1.16A 4x1yB-4z23A:
undetectable		 4x1yB-4z23A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II) 		5 LEU K 131
LEU K 143
THR K 235
VAL K 123
ILE K 145
 None
 1.13A 4x1yB-5anbK:
undetectable		 4x1yB-5anbK:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm5 HYDROXYETHYLTHIAZOLE
KINASE

(Staphylococcus
aureus) 		PF02110
(HK) 		5 CYH A 102
LEU A 106
THR A 160
VAL A  92
ILE A 121
 None
 1.18A 4x1yB-5cm5A:
3.2		 4x1yB-5cm5A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE

(Thosea asigna
virus) 		no annotation 5 LEU B 517
LEU B 513
LEU B 329
MET B 307
ALA B 347
 None
 0.99A 4x1yB-5cyrB:
undetectable		 4x1yB-5cyrB:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		5 LEU A 298
LEU A 412
THR A 152
ALA A 123
VAL A 127
 None
 1.11A 4x1yB-5e78A:
undetectable		 4x1yB-5e78A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eku ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		PF06325
(PrmA) 		5 CYH A 215
LEU A 218
ALA A 299
LEU A 301
VAL A 257
 None
 1.07A 4x1yB-5ekuA:
undetectable		 4x1yB-5ekuA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE

(Pyrococcus
horikoshii) 		PF00004
(AAA) 		5 LEU A 234
LEU A 262
ALA A 250
VAL A 248
ILE A 208
 None
 1.14A 4x1yB-5eqtA:
undetectable		 4x1yB-5eqtA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 LEU A 325
LEU A 337
ALA A 328
THR A 375
VAL A 350
 None
 1.14A 4x1yB-5f56A:
3.3		 4x1yB-5f56A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
ALPHA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 LEU C 212
LEU C  37
THR C 170
ALA C 163
ILE C  33
 None
 1.12A 4x1yB-5fmgC:
undetectable		 4x1yB-5fmgC:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fno MANGANESE
LIPOXYGENASE

(Magnaporthe
oryzae) 		PF00305
(Lipoxygenase) 		5 LEU A 594
LEU A 538
MET A 541
ALA A 462
ILE A 402
 None
 1.16A 4x1yB-5fnoA:
undetectable		 4x1yB-5fnoA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 CYH A 338
LEU A 362
LEU A 317
LEU A 344
ILE A 331
 None
 1.09A 4x1yB-5gr8A:
undetectable		 4x1yB-5gr8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6o PORPHOBILINOGEN
DEAMINASE

(Vibrio cholerae) 		no annotation 5 LEU A 244
ASN A 241
MET A 240
ALA A 267
VAL A 278
 None
 1.15A 4x1yB-5h6oA:
undetectable		 4x1yB-5h6oA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixq RECEPTOR-LIKE
PROTEIN KINASE 5

(Arabidopsis
thaliana) 		PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 LEU A 189
LEU A 217
LEU A 183
THR A 178
ILE A 155
 None
 1.18A 4x1yB-5ixqA:
undetectable		 4x1yB-5ixqA:
21.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 LEU A 253
MET A 257
THR A 311
ALA A 313
ILE A 367
 None
 1.12A 4x1yB-5mjsA:
53.3		 4x1yB-5mjsA:
58.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 LEU B 255
ASN B 258
MET B 259
THR B 314
ILE B 378
 None
 0.86A 4x1yB-5n5nB:
54.0		 4x1yB-5n5nB:
97.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 LEU B 255
MET B 259
THR B 314
ALA B 316
ILE B 378
 None
 1.02A 4x1yB-5n5nB:
54.0		 4x1yB-5n5nB:
97.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 MET B 259
THR B 314
ALA B 316
VAL B 318
ILE B 378
 None
 0.78A 4x1yB-5n5nB:
54.0		 4x1yB-5n5nB:
97.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvd TM16

(Trichuris muris) 		PF01161
(PBP) 		5 CYH A  29
LEU A  28
LEU A  56
ALA A  31
VAL A 126
 None
 0.95A 4x1yB-5tvdA:
undetectable		 4x1yB-5tvdA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvj ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycobacterium
tuberculosis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 LEU A 217
ALA A 255
MET A 262
ALA A 236
VAL A 238
 None
 0.97A 4x1yB-5tvjA:
undetectable		 4x1yB-5tvjA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vop 5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 5 LEU A 624
LEU A 586
THR A 534
ALA A 548
ILE A 537
 None
 1.13A 4x1yB-5vopA:
undetectable		 4x1yB-5vopA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1j THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Echinococcus
granulosus) 		no annotation 5 CYH A 291
LEU A 388
ALA A 390
VAL A 312
ILE A 336
 None
 1.12A 4x1yB-5w1jA:
undetectable		 4x1yB-5w1jA:
20.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 LEU B 253
ASN B 256
THR B 312
ALA B 314
ILE B 368
 None
 0.84A 4x1yB-5w3jB:
53.8		 4x1yB-5w3jB:
75.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wkn NUCLEOPROTEIN

(Mammalian
rubulavirus 5) 		no annotation 5 LEU A  73
THR A 178
ALA A 174
VAL A 170
ILE A 219
 None
 1.11A 4x1yB-5wknA:
undetectable		 4x1yB-5wknA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z9s GLYCOSYL HYDROLASE
FAMILY 3 PROTEIN

(Bifidobacterium
longum) 		no annotation 5 LEU A 411
ASN A 597
ALA A 595
VAL A 558
ILE A 386
 None
 1.16A 4x1yB-5z9sA:
undetectable		 4x1yB-5z9sA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5c KATANIN P60
ATPASE-CONTAINING
SUBUNIT A-LIKE 1

(Homo sapiens) 		no annotation 5 LEU A 333
LEU A 368
THR A 358
ALA A 356
VAL A 354
 None
 1.02A 4x1yB-6b5cA:
undetectable		 4x1yB-6b5cA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf6 INSULIN-DEGRADING
ENZYME

(Homo sapiens) 		no annotation 5 LEU A 642
LEU A 616
LEU A 574
ASN A 573
ILE A 733
 None
 1.16A 4x1yB-6bf6A:
undetectable		 4x1yB-6bf6A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 10
N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT

(Homo sapiens) 		no annotation 5 LEU A 541
LEU B  11
ASN B  13
MET B  14
ALA B   6
 None
 0.96A 4x1yB-6c9mA:
undetectable		 4x1yB-6c9mA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
EXONUCLEASE RRP44

(Homo sapiens) 		no annotation 5 LEU K 551
ALA K 507
LEU K 558
VAL K 555
ILE K 459
 None
 1.05A 4x1yB-6d6qK:
undetectable		 4x1yB-6d6qK:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eyy ACRIIA6

(Streptococcus
phage 73) 		no annotation 5 LEU A 104
LEU A 179
ASN A 177
VAL A 136
ILE A 182
 None
 1.15A 4x1yB-6eyyA:
undetectable		 4x1yB-6eyyA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Mus musculus) 		no annotation 5 CYH M 199
LEU M 160
LEU M 195
ALA M 163
THR M 182
 None
None
3PE  M 502 ( 4.1A)
3PE  M 502 ( 4.3A)
None
 1.10A 4x1yB-6g2jM:
undetectable		 4x1yB-6g2jM:
11.81