SIMILAR PATTERNS OF AMINO ACIDS FOR 4X1K_D_LOCD502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE

(Streptomyces
antibioticus) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03726
(PNPase) 		4 ASN A 476
SER A 576
ALA A 477
VAL A 479
 None
 1.17A 4x1kC-1e3hA:
undetectable		 4x1kC-1e3hA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eav MOLYBDOPTERIN
BIOSYNTHESIS CNX1
PROTEIN

(Arabidopsis
thaliana) 		PF00994
(MoCF_biosynth) 		4 ASN A 140
SER A 112
ALA A 143
VAL A 144
 None
 1.00A 4x1kC-1eavA:
undetectable		 4x1kC-1eavA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fbn MJ FIBRILLARIN
HOMOLOGUE

(Methanocaldococcus
jannaschii) 		PF01269
(Fibrillarin) 		4 ASN A 123
SER A  29
ALA A  93
VAL A  92
 None
 1.24A 4x1kC-1fbnA:
3.4		 4x1kC-1fbnA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7h ALKALINE PHOSPHATASE

(Pandalus
borealis) 		PF00245
(Alk_phosphatase) 		4 ASN A  78
SER A  86
ALA A  88
VAL A 103
 None
ZN  A 478 (-1.7A)
None
None
 1.31A 4x1kC-1k7hA:
undetectable		 4x1kC-1k7hA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khd ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Pectobacterium
carotovorum) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 ASN A 195
SER A 150
ALA A 118
VAL A 117
 None
 1.00A 4x1kC-1khdA:
2.2		 4x1kC-1khdA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m22 PEPTIDE AMIDASE

(Stenotrophomonas
maltophilia) 		PF01425
(Amidase) 		4 ASN A 234
SER A 203
ALA A 207
VAL A 210
 None
 1.32A 4x1kC-1m22A:
undetectable		 4x1kC-1m22A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
40 KDA SUBUNIT

(Paracoccus
denitrificans) 		no annotation 4 ASN B 286
SER B 245
ALA B 247
VAL B 248
 None
 1.11A 4x1kC-1pbyB:
undetectable		 4x1kC-1pbyB:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkx CDP-GLUCOSE-4,6-DEHY
DRATASE

(Yersinia
pseudotuberculosis) 		PF16363
(GDP_Man_Dehyd) 		4 ASN A 129
SER A 160
ALA A 164
VAL A 167
 None
 1.24A 4x1kC-1rkxA:
6.7		 4x1kC-1rkxA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua7 ALPHA-AMYLASE

(Bacillus
subtilis) 		PF00128
(Alpha-amylase) 		4 ASN A 396
SER A 418
ALA A 420
VAL A 372
 None
 1.25A 4x1kC-1ua7A:
undetectable		 4x1kC-1ua7A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulv GLUCODEXTRANASE

(Arthrobacter
globiformis) 		PF00723
(Glyco_hydro_15)
PF09136
(Glucodextran_B)
PF09137
(Glucodextran_N)
PF09985
(Glucodextran_C) 		4 ASN A 202
SER A 213
ALA A 181
VAL A 180
 None
 1.35A 4x1kC-1ulvA:
undetectable		 4x1kC-1ulvA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uqw PUTATIVE BINDING
PROTEIN YLIB

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 ASN A  82
SER A 144
ALA A  85
VAL A  86
 None
 1.19A 4x1kC-1uqwA:
undetectable		 4x1kC-1uqwA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urd MALTOSE-BINDING
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF01547
(SBP_bac_1) 		4 ASN A 392
SER A 370
ALA A 368
VAL A 365
 None
 1.29A 4x1kC-1urdA:
undetectable		 4x1kC-1urdA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdw HYPOTHETICAL PROTEIN
PH1897

(Pyrococcus
horikoshii) 		PF00459
(Inositol_P) 		4 ASN A 240
SER A 150
ALA A 189
VAL A 190
 None
 1.23A 4x1kC-1vdwA:
undetectable		 4x1kC-1vdwA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcd MAJOR STRUCTURAL
PROTEIN VP2

(Infectious
bursal disease
virus) 		PF01766
(Birna_VP2) 		4 ASN J 125
SER J  54
ALA J 353
VAL J 352
 None
 1.28A 4x1kC-1wcdJ:
undetectable		 4x1kC-1wcdJ:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x7h PUTATIVE KETOACYL
REDUCTASE

(Streptomyces
coelicolor) 		PF00106
(adh_short) 		4 ASN A  90
SER A  16
ALA A  14
VAL A  35
 NDP  A 301 (-3.3A)
NDP  A 301 (-3.1A)
None
None
 1.26A 4x1kC-1x7hA:
6.9		 4x1kC-1x7hA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xww LOW MOLECULAR WEIGHT
PHOSPHOTYROSINE
PROTEIN PHOSPHATASE

(Homo sapiens) 		PF01451
(LMWPc) 		4 ASN A  15
SER A  54
ALA A  74
VAL A  51
 None
 1.26A 4x1kC-1xwwA:
2.8		 4x1kC-1xwwA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3t HYPOTHETICAL PROTEIN
YXAG

(Bacillus
subtilis) 		PF07883
(Cupin_2) 		4 ASN A  38
SER A 128
ALA A 124
VAL A 123
 None
 1.35A 4x1kC-1y3tA:
undetectable		 4x1kC-1y3tA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxo CONSERVED
HYPOTHETICAL PROTEIN
Q8A1P1

(Bacteroides
thetaiotaomicron) 		no annotation 4 ASN A 191
SER A 196
ALA A 146
VAL A 147
 None
 1.27A 4x1kC-1zxoA:
undetectable		 4x1kC-1zxoA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c9k PESTICIDAL CRYSTAL
PROTEIN CRY4AA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		4 ASN A 642
SER A 607
ALA A 612
VAL A 611
 None
 1.34A 4x1kC-2c9kA:
undetectable		 4x1kC-2c9kA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cgj L-RHAMNULOSE KINASE

(Escherichia
coli) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ASN A 173
SER A 235
ALA A 232
VAL A 231
 None
 1.15A 4x1kC-2cgjA:
undetectable		 4x1kC-2cgjA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		4 ASN A 179
SER A 148
ALA A 152
VAL A 155
 None
 1.32A 4x1kC-2dc0A:
undetectable		 4x1kC-2dc0A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ASN A 352
SER A  47
ALA A  45
VAL A  44
 None
 0.63A 4x1kC-2e5vA:
undetectable		 4x1kC-2e5vA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		4 ASN A 575
SER A 503
ALA A 562
VAL A 561
 None
 0.88A 4x1kC-2eaeA:
undetectable		 4x1kC-2eaeA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fqd BLUE COPPER OXIDASE
CUEO

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ASN A 245
SER A 271
ALA A 247
VAL A 296
 None
 1.17A 4x1kC-2fqdA:
undetectable		 4x1kC-2fqdA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipa PROTEIN ARSC

(Bacillus
subtilis) 		PF01451
(LMWPc) 		4 ASN B  47
SER B  17
ALA B  48
VAL B  49
 None
 1.12A 4x1kC-2ipaB:
3.4		 4x1kC-2ipaB:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 ASN A 156
SER A 314
ALA A 300
VAL A 299
 PLP  A1494 ( 4.7A)
PLP  A1494 ( 4.9A)
None
None
 0.98A 4x1kC-2jisA:
3.0		 4x1kC-2jisA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l80 UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 13

(Homo sapiens) 		PF02148
(zf-UBP) 		4 ASN A  36
SER A  85
ALA A  70
VAL A  71
 None
 1.01A 4x1kC-2l80A:
undetectable		 4x1kC-2l80A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntb PECTINESTERASE A

(Dickeya
dadantii) 		PF01095
(Pectinesterase) 		4 ASN A  65
SER A 126
ALA A  89
VAL A  90
 None
 0.80A 4x1kC-2ntbA:
undetectable		 4x1kC-2ntbA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2q FORMYLTETRAHYDROFOLA
TE DEHYDROGENASE

(Rattus
norvegicus) 		PF00171
(Aldedh) 		4 ASN A 706
SER A 678
ALA A 709
VAL A 699
 GOL  A   1 (-3.3A)
None
None
None
 1.32A 4x1kC-2o2qA:
2.7		 4x1kC-2o2qA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6h HYPOTHETICAL PROTEIN

(Aeropyrum
pernix) 		PF01894
(UPF0047) 		4 ASN A  90
SER A  96
ALA A  47
VAL A 117
 None
 0.97A 4x1kC-2p6hA:
undetectable		 4x1kC-2p6hA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qbu PRECORRIN-2
METHYLTRANSFERASE

(Methanothermobacter
thermautotrophicus) 		PF00590
(TP_methylase) 		4 ASN A 202
SER A 178
ALA A 201
VAL A 200
 None
 1.25A 4x1kC-2qbuA:
undetectable		 4x1kC-2qbuA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsf DNA REPAIR PROTEIN
RAD4

(Saccharomyces
cerevisiae) 		PF03835
(Rad4)
PF10403
(BHD_1)
PF10405
(BHD_3) 		4 ASN A 570
SER A 548
ALA A 615
VAL A 614
 None
 1.36A 4x1kC-2qsfA:
undetectable		 4x1kC-2qsfA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qts ACID-SENSING ION
CHANNEL

(Gallus gallus) 		PF00858
(ASC) 		4 ASN A 199
SER A 252
ALA A  90
VAL A  91
 None
NAG  A   1 ( 4.0A)
None
None
 1.25A 4x1kC-2qtsA:
undetectable		 4x1kC-2qtsA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 ASN G 612
SER G 639
ALA G 608
VAL G 607
 None
 1.33A 4x1kC-2uv8G:
0.0		 4x1kC-2uv8G:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v2f PENICILLIN BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		4 ASN F 274
SER F 331
ALA F 361
VAL F 362
 None
 1.41A 4x1kC-2v2fF:
undetectable		 4x1kC-2v2fF:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlc TYPE 2
RIBOSOME-INACTIVATIN
G PROTEIN CINNAMOMIN
III

(Cinnamomum
camphora) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		4 ASN A 206
SER A 219
ALA A 207
VAL A 208
 None
 1.38A 4x1kC-2vlcA:
undetectable		 4x1kC-2vlcA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjs LAMININ SUBUNIT
ALPHA-2

(Mus musculus) 		PF00054
(Laminin_G_1) 		4 ASN A2431
SER A2448
ALA A2446
VAL A2445
 NAG  A4003 (-1.9A)
None
None
None
 1.29A 4x1kC-2wjsA:
undetectable		 4x1kC-2wjsA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0h PROBABLE PORIN

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		4 ASN A 385
SER A 349
ALA A 361
VAL A 360
 None
 1.33A 4x1kC-2y0hA:
undetectable		 4x1kC-2y0hA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg1 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Heterobasidion
annosum) 		PF00840
(Glyco_hydro_7) 		4 ASN A 163
SER A 167
ALA A 165
VAL A   3
 PCA  A   1 (-3.6A)
None
PCA  A   1 ( 3.6A)
None
 1.26A 4x1kC-2yg1A:
undetectable		 4x1kC-2yg1A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zhl GALECTIN-9

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ASN A  63
SER A 139
ALA A  46
VAL A  47
 GAL  A1493 (-3.6A)
None
NAG  A1491 ( 3.9A)
None
 1.03A 4x1kC-2zhlA:
undetectable		 4x1kC-2zhlA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b43 TITIN

(Oryctolagus
cuniculus) 		PF07679
(I-set) 		4 ASN A 541
SER A 535
ALA A 537
VAL A 487
 None
 1.06A 4x1kC-3b43A:
undetectable		 4x1kC-3b43A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1t HALOGENASE

(Chondromyces
crocatus) 		PF04820
(Trp_halogenase) 		4 ASN A 331
SER A  24
ALA A 327
VAL A 326
 None
 1.35A 4x1kC-3e1tA:
undetectable		 4x1kC-3e1tA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		4 ASN A 332
SER A 308
ALA A 329
VAL A 349
 None
 1.40A 4x1kC-3g06A:
undetectable		 4x1kC-3g06A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)

(Corynebacterium
glutamicum) 		PF13377
(Peripla_BP_3) 		4 ASN A 242
SER A 186
ALA A 216
VAL A 217
 None
 1.40A 4x1kC-3gybA:
2.2		 4x1kC-3gybA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbx GLUTAMATE
DECARBOXYLASE 1

(Arabidopsis
thaliana) 		PF00282
(Pyridoxal_deC) 		4 ASN A 215
SER A 379
ALA A 377
VAL A 376
 None
 1.19A 4x1kC-3hbxA:
undetectable		 4x1kC-3hbxA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5

(Homo sapiens) 		PF00443
(UCH)
PF00627
(UBA)
PF02148
(zf-UBP) 		4 ASN A 211
SER A 260
ALA A 245
VAL A 246
 None
 0.83A 4x1kC-3ihpA:
undetectable		 4x1kC-3ihpA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob4 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ARAH 2

(Arachis
duranensis;
Escherichia
coli) 		PF00234
(Tryp_alpha_amyl)
PF13416
(SBP_bac_8) 		4 ASN A 367
SER A 337
ALA A 342
VAL A 343
 None
 1.37A 4x1kC-3ob4A:
undetectable		 4x1kC-3ob4A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wv6 GALECTIN-9

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ASN A  63
SER A 139
ALA A  46
VAL A  47
 GAL  A 402 (-3.9A)
None
None
None
 0.98A 4x1kC-3wv6A:
undetectable		 4x1kC-3wv6A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX ALPHA-CHAIN
FADB
FATTY ACID
BETA-OXIDATION
COMPLEX BETA-CHAIN
FADA

(Mycobacterium
tuberculosis) 		PF00108
(Thiolase_N)
PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
PF02803
(Thiolase_C) 		4 ASN C 198
SER A 284
ALA A 288
VAL A 291
 None
 1.30A 4x1kC-4b3iC:
undetectable		 4x1kC-4b3iC:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1i BETA-GALACTOSIDASE,
PUTATIVE, BGL35A

(Cellvibrio
japonicus) 		PF02449
(Glyco_hydro_42) 		4 ASN A 281
SER A  91
ALA A 348
VAL A 347
 None
 1.28A 4x1kC-4d1iA:
undetectable		 4x1kC-4d1iA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgu LEGUMAIN

(Homo sapiens) 		PF01650
(Peptidase_C13) 		4 ASN A 211
SER A 215
ALA A 210
VAL A 267
 None
 1.39A 4x1kC-4fguA:
2.6		 4x1kC-4fguA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp8 ANTIBODY C05, HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 ASN H  52
SER H  97
ALA H  33
VAL H  34
 None
 1.04A 4x1kC-4fp8H:
undetectable		 4x1kC-4fp8H:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gga CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ASN A 329
SER A 378
ALA A 357
VAL A 358
 None
 0.77A 4x1kC-4ggaA:
undetectable		 4x1kC-4ggaA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glw DNA LIGASE

(Streptococcus
pneumoniae) 		PF01653
(DNA_ligase_aden) 		4 ASN A 138
SER A 116
ALA A 126
VAL A 125
 None
 1.31A 4x1kC-4glwA:
undetectable		 4x1kC-4glwA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnj TRIOSEPHOSPHATE
ISOMERASE

(Leishmania sp.
'siamensis') 		PF00121
(TIM) 		4 ASN A  12
SER A  45
ALA A  43
VAL A  42
 None
 1.28A 4x1kC-4gnjA:
undetectable		 4x1kC-4gnjA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxr MALONYL COA
SYNTHETASE,
BENZOATE-COA LIGASE
CHIMERIC PROTEIN

(Paraburkholderia
xenovorans;
Rhodopseudomonas
palustris) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ASN A 484
SER A 277
ALA A 488
VAL A 489
 None
CO3  A 608 ( 2.3A)
None
MLY  A 491 ( 4.9A)
 1.32A 4x1kC-4gxrA:
undetectable		 4x1kC-4gxrA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjh PHOSPHOMANNOMUTASE

(Brucella
melitensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 ASN A 283
SER A 380
ALA A 378
VAL A 377
 None
 1.30A 4x1kC-4hjhA:
undetectable		 4x1kC-4hjhA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxc PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
uniformis) 		PF06439
(DUF1080) 		4 ASN A 171
SER A 189
ALA A 187
VAL A 168
 None
 1.40A 4x1kC-4hxcA:
undetectable		 4x1kC-4hxcA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iau BETA-GAMMA-CRYSTALLI
N

(Geodia cydonium) 		PF00030
(Crystall) 		4 ASN A 153
SER A 115
ALA A 146
VAL A 151
 GOL  A 801 (-3.3A)
None
None
None
 1.02A 4x1kC-4iauA:
undetectable		 4x1kC-4iauA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyj GDSL-LIKE PROTEIN

(Bacteroides
uniformis) 		PF13472
(Lipase_GDSL_2) 		4 ASN A 194
SER A 199
ALA A 196
VAL A 190
 None
 1.40A 4x1kC-4iyjA:
undetectable		 4x1kC-4iyjA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knc ALGINATE
BIOSYNTHESIS PROTEIN
ALGX

(Pseudomonas
aeruginosa) 		no annotation 4 ASN B 291
SER B 295
ALA B 293
VAL B 266
 None
 1.14A 4x1kC-4kncB:
undetectable		 4x1kC-4kncB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lps HYDROGENASE/UREASE
NICKEL INCORPORATION
PROTEIN HYPB

(Helicobacter
pylori) 		PF02492
(cobW) 		4 ASN A  50
SER A 238
ALA A 150
VAL A  48
 None
MLI  A 309 ( 4.2A)
None
None
 1.27A 4x1kC-4lpsA:
3.2		 4x1kC-4lpsA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lw8 PUTATIVE EPIMERASE

(Burkholderia
cenocepacia) 		PF01370
(Epimerase) 		4 ASN A 150
SER A 128
ALA A 153
VAL A 154
 None
 1.24A 4x1kC-4lw8A:
6.2		 4x1kC-4lw8A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1e PURINE NUCLEOSIDE
PHOSPHORYLASE

(Planctopirus
limnophila) 		PF01048
(PNP_UDP_1) 		4 ASN A 135
SER A 189
ALA A 187
VAL A 186
 None
 1.21A 4x1kC-4m1eA:
3.3		 4x1kC-4m1eA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n14 CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ASN A 329
SER A 378
ALA A 357
VAL A 358
 None
 0.99A 4x1kC-4n14A:
undetectable		 4x1kC-4n14A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oca UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF01041
(DegT_DnrJ_EryC1) 		4 ASN A  41
SER A  61
ALA A  59
VAL A  58
 None
 1.10A 4x1kC-4ocaA:
undetectable		 4x1kC-4ocaA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqs CYP105AS1

(Amycolatopsis
orientalis) 		PF00067
(p450) 		4 ASN A 247
SER A 387
ALA A 389
VAL A 282
 None
None
None
HEM  A 501 ( 4.8A)
 1.13A 4x1kC-4oqsA:
undetectable		 4x1kC-4oqsA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf7 ARGININE KINASE

(Anthopleura
japonica) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		4 ASN A 278
SER A 134
ALA A 132
VAL A 131
 ARG  A 805 ( 4.6A)
None
None
None
 1.29A 4x1kC-4rf7A:
undetectable		 4x1kC-4rf7A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmx PHI92_GP150

(Enterobacteria
phage phi92) 		no annotation 4 ASN A 392
SER A 430
ALA A 428
VAL A 427
 SR  A 907 ( 4.6A)
None
None
None
 1.10A 4x1kC-4rmxA:
undetectable		 4x1kC-4rmxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmx PHI92_GP150

(Enterobacteria
phage phi92) 		no annotation 4 ASN A 392
SER A 430
ALA A 428
VAL A 462
 SR  A 907 ( 4.6A)
None
None
None
 1.30A 4x1kC-4rmxA:
undetectable		 4x1kC-4rmxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4sli INTRAMOLECULAR
TRANS-SIALIDASE

(Macrobdella
decora) 		PF02973
(Sialidase)
PF13088
(BNR_2) 		4 ASN A 675
SER A 701
ALA A 703
VAL A 704
 None
 1.37A 4x1kC-4sliA:
undetectable		 4x1kC-4sliA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfe RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA

(Mus musculus) 		PF00041
(fn3) 		4 ASN A 354
SER A 359
ALA A 402
VAL A 401
 None
 1.10A 4x1kC-4yfeA:
undetectable		 4x1kC-4yfeA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysh GLYCINE OXIDASE

(Geobacillus
kaustophilus) 		PF01266
(DAO) 		4 ASN A 337
SER A  69
ALA A  66
VAL A  63
 None
 1.39A 4x1kC-4yshA:
undetectable		 4x1kC-4yshA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 ASN A 580
SER A 627
ALA A 603
VAL A 602
 None
 1.39A 4x1kC-4z64A:
undetectable		 4x1kC-4z64A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8i PEPTIDOGLYCAN
RECOGNITION PROTEIN
3

(Branchiostoma
belcheri) 		PF01510
(Amidase_2) 		4 ASN A  26
SER A 185
ALA A  29
VAL A  30
 None
 1.38A 4x1kC-4z8iA:
undetectable		 4x1kC-4z8iA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqg 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Moraxella
catarrhalis) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 ASN A 127
SER A 112
ALA A 102
VAL A 101
 NAD  A 501 (-4.4A)
None
None
None
 1.18A 4x1kC-4zqgA:
1.8		 4x1kC-4zqgA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu9 ELONGATION FACTOR
SELB

(Aquifex
aeolicus) 		PF00009
(GTP_EFTU)
PF09107
(SelB-wing_3) 		4 ASN A 175
SER A 200
ALA A 238
VAL A 237
 None
 0.92A 4x1kC-4zu9A:
2.1		 4x1kC-4zu9A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7m BETA-XYLOSIDASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ASN A 356
SER A 250
ALA A 202
VAL A 201
 None
 1.13A 4x1kC-5a7mA:
undetectable		 4x1kC-5a7mA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fok IRON TRANSPORT OUTER
MEMBRANE RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ASN A 121
SER A 227
ALA A 211
VAL A 210
 None
None
None
C8E  A1722 ( 4.7A)
 1.01A 4x1kC-5fokA:
undetectable		 4x1kC-5fokA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g53 ADENOSINE RECEPTOR
A2A

(Homo sapiens) 		PF00001
(7tm_1) 		4 ASN A  24
SER A  91
ALA A  49
VAL A  46
 None
 1.27A 4x1kC-5g53A:
undetectable		 4x1kC-5g53A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ASN A 756
SER A 819
ALA A 816
VAL A 696
 None
None
None
PGO  A 901 (-4.3A)
 1.16A 4x1kC-5i2gA:
undetectable		 4x1kC-5i2gA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		4 ASN A4034
SER A4004
ALA A4009
VAL A4010
 None
 1.39A 4x1kC-5ii5A:
undetectable		 4x1kC-5ii5A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ASN Q 329
SER Q 378
ALA Q 357
VAL Q 358
 None
 0.78A 4x1kC-5lcwQ:
undetectable		 4x1kC-5lcwQ:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 ASN R 329
SER R 378
ALA R 357
VAL R 358
 None
 0.79A 4x1kC-5lcwR:
undetectable		 4x1kC-5lcwR:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 4 ASN A 121
SER A 214
ALA A 212
VAL A 211
 None
 1.06A 4x1kC-5necA:
undetectable		 4x1kC-5necA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nec TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Pseudomonas
aeruginosa) 		no annotation 4 ASN A 121
SER A 228
ALA A 212
VAL A 211
 None
 1.03A 4x1kC-5necA:
undetectable		 4x1kC-5necA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szx ZTA TRANSCRIPTION
FACTOR

(Human
gammaherpesvirus
4) 		no annotation 4 ASN A 182
SER A 189
ALA A 185
VAL A 184
 None
 1.28A 4x1kC-5szxA:
undetectable		 4x1kC-5szxA:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2a AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Brucella canis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ASN A 243
SER A 294
ALA A 292
VAL A 319
 None
 1.39A 4x1kC-5u2aA:
undetectable		 4x1kC-5u2aA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4o ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bacillus
anthracis) 		PF00496
(SBP_bac_5) 		4 ASN A 121
SER A 183
ALA A 124
VAL A 125
 None
 1.18A 4x1kC-5u4oA:
undetectable		 4x1kC-5u4oA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkw ADENYLOSUCCINATE
LYASE

(Candida
albicans) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 ASN A 418
SER A 404
ALA A 407
VAL A 410
 None
 1.25A 4x1kC-5vkwA:
undetectable		 4x1kC-5vkwA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Neisseria
gonorrhoeae) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ASN A 154
SER A 120
ALA A 148
VAL A 130
 None
NAD  A 401 (-3.2A)
None
None
 1.39A 4x1kC-5vmtA:
3.0		 4x1kC-5vmtA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 4 ASN A  52
SER A 122
ALA A  77
VAL A  74
 None
NA  A1224 (-2.3A)
None
OLA  A1207 ( 4.5A)
 1.20A 4x1kC-5wivA:
undetectable		 4x1kC-5wivA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axg RAS GUANYL-RELEASING
PROTEIN 4

(Homo sapiens) 		no annotation 4 ASN A 288
SER A 249
ALA A 292
VAL A 293
 None
 1.29A 4x1kC-6axgA:
undetectable		 4x1kC-6axgA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfi VIN1

(Oscarella
pearsei) 		no annotation 4 ASN A 539
SER A 573
ALA A 535
VAL A 534
 None
 1.18A 4x1kC-6bfiA:
undetectable		 4x1kC-6bfiA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		no annotation 4 ASN A  52
SER A 121
ALA A  77
VAL A  74
 None
 1.16A 4x1kC-6cm4A:
undetectable		 4x1kC-6cm4A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1

(Homo sapiens) 		no annotation 4 ASN R  27
SER R  94
ALA R  52
VAL R  49
 None
 1.33A 4x1kC-6d9hR:
undetectable		 4x1kC-6d9hR:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dxt -

(-) 		no annotation 4 ASN A 211
SER A 260
ALA A 245
VAL A 246
 UNX  A 702 ( 4.2A)
None
None
None
 0.77A 4x1kC-6dxtA:
undetectable		 4x1kC-6dxtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1

(Mus musculus) 		no annotation 4 ASN A 165
SER A 323
ALA A 309
VAL A 308
 PLP  A 601 ( 4.5A)
PLP  A 601 ( 4.8A)
None
None
 0.97A 4x1kC-6enzA:
undetectable		 4x1kC-6enzA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 4 ASN A1246
SER A1173
ALA A1186
VAL A1196
 None
 1.34A 4x1kC-6eojA:
undetectable		 4x1kC-6eojA:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esl BACTERIAL LEUCYL
AMINOPEPTIDASE

(Legionella
pneumophila) 		no annotation 4 ASN A 325
SER A 294
ALA A 331
VAL A 265
 None
 1.28A 4x1kC-6eslA:
3.2		 4x1kC-6eslA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amk TRIOSE PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00121
(TIM) 		5 LEU A 232
THR A  44
ALA A  42
VAL A  40
ALA A   9
 PGA  A 600 ( 4.2A)
None
None
None
None
 1.15A 4x1kD-1amkA:
2.9		 4x1kD-1amkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkh MUCONATE LACTONIZING
ENZYME

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 128
LEU A 319
THR A 301
ALA A 287
ILE A 274
 None
 1.13A 4x1kD-1bkhA:
3.2		 4x1kD-1bkhA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE

(Pseudomonas
stutzeri) 		PF00128
(Alpha-amylase)
PF09081
(DUF1921) 		5 LEU A  95
ASN A 180
ALA A 187
VAL A 109
ALA A  99
 None
 1.13A 4x1kD-1gcyA:
3.6		 4x1kD-1gcyA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7g 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Escherichia
coli) 		PF02348
(CTP_transf_3) 		5 CYH A 126
LEU A 125
ALA A 150
VAL A 142
ILE A 212
 None
 1.12A 4x1kD-1h7gA:
undetectable		 4x1kD-1h7gA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdi PHOSPHOGLYCERATE
KINASE

(Sus scrofa) 		PF00162
(PGK) 		5 LEU A 268
LEU A 211
LYS A 219
VAL A 230
ALA A 209
 None
None
AMP  A 417 (-2.8A)
None
None
 1.07A 4x1kD-1hdiA:
undetectable		 4x1kD-1hdiA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixx COAGULATION FACTORS
IX/X-BINDING PROTEIN

(Protobothrops
flavoviridis) 		PF00059
(Lectin_C) 		5 ASN A  58
MET A  59
VAL A  40
LYS A  15
ILE A  66
 None
 1.10A 4x1kD-1ixxA:
undetectable		 4x1kD-1ixxA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jro XANTHINE
DEHYDROGENASE, CHAIN
A

(Rhodobacter
capsulatus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C) 		5 LEU A 129
MET A  50
ALA A 115
VAL A  91
ILE A  81
 None
 1.16A 4x1kD-1jroA:
undetectable		 4x1kD-1jroA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3r CONSERVED PROTEIN
MT0001

(Methanothermobacter
thermautotrophicus) 		PF02598
(Methyltrn_RNA_3) 		5 LEU A 260
LEU A   6
VAL A 185
ALA A 213
ILE A 231
 None
 1.15A 4x1kD-1k3rA:
undetectable		 4x1kD-1k3rA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		5 LEU A  46
THR A 156
ALA A 154
VAL A 152
ALA A  16
 None
 1.15A 4x1kD-1mb9A:
undetectable		 4x1kD-1mb9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1

(Homo sapiens) 		PF00899
(ThiF) 		5 LEU A 185
ALA A 268
VAL A 272
ALA A 275
ILE A 247
 None
 1.10A 4x1kD-1r4nA:
2.4		 4x1kD-1r4nA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		5 LEU A 386
ASN A 420
THR A 489
ALA A 506
ALA A 279
 None
 1.04A 4x1kD-1t6pA:
undetectable		 4x1kD-1t6pA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcd TRIOSEPHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00121
(TIM) 		5 LEU A 233
THR A  45
ALA A  43
VAL A  41
ALA A  10
 None
 1.15A 4x1kD-1tcdA:
undetectable		 4x1kD-1tcdA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG

(Mus musculus) 		PF00225
(Kinesin) 		6 MET A  81
ALA A 326
VAL A 328
LYS A   7
ALA A   9
ILE A  93
 None
 1.04A 4x1kD-1vfwA:
undetectable		 4x1kD-1vfwA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjo ALANINE--GLYOXYLATE
AMINOTRANSFERASE

(Nostoc sp. PCC
7120) 		PF00266
(Aminotran_5) 		5 LEU A 112
LEU A 202
ALA A  91
VAL A  94
ALA A  93
 None
 1.08A 4x1kD-1vjoA:
undetectable		 4x1kD-1vjoA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5t ORC2

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13401
(AAA_22) 		5 LEU A 104
ASN A 132
VAL A 142
ALA A  90
ILE A 180
 None
 1.14A 4x1kD-1w5tA:
undetectable		 4x1kD-1w5tA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aym U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A

(Drosophila
melanogaster) 		PF00076
(RRM_1) 		5 LEU A  28
ASN A  15
VAL A  50
ALA A  48
ILE A  78
 None
 1.16A 4x1kD-2aymA:
undetectable		 4x1kD-2aymA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azp HYPOTHETICAL PROTEIN
PA1268

(Pseudomonas
aeruginosa) 		PF05544
(Pro_racemase) 		5 CYH A 246
LEU A 247
LEU A 166
ALA A 136
ALA A 158
 None
 1.15A 4x1kD-2azpA:
undetectable		 4x1kD-2azpA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7l 455AA LONG
HYPOTHETICAL
PHOSPHO-SUGAR MUTASE

(Sulfurisphaera
tokodaii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 LEU A 348
LYS A 273
ASN A 274
ALA A 323
ILE A 281
 None
 1.13A 4x1kD-2f7lA:
undetectable		 4x1kD-2f7lA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 ASN A 160
THR A 393
VAL A 220
ALA A 170
ILE A 228
 None
 1.05A 4x1kD-2gepA:
2.0		 4x1kD-2gepA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6e HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF02621
(VitK2_biosynth) 		5 LEU A 220
LEU A  34
ASN A  63
ALA A  19
VAL A  40
 None
 1.07A 4x1kD-2i6eA:
undetectable		 4x1kD-2i6eA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5t GLUTAMATE 5-KINASE

(Escherichia
coli) 		PF00696
(AA_kinase)
PF01472
(PUA) 		5 LEU A 155
LEU A 121
ALA A 162
VAL A   8
ILE A 229
 None
 1.11A 4x1kD-2j5tA:
undetectable		 4x1kD-2j5tA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kzf RIBOSOME-BINDING
FACTOR A

(Thermotoga
maritima) 		PF02033
(RBFA) 		5 LEU A  18
LEU A  11
ALA A  50
VAL A  41
ILE A  93
 None
 1.06A 4x1kD-2kzfA:
undetectable		 4x1kD-2kzfA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 5 LEU A  55
LEU A  62
THR A 165
VAL A 295
ALA A 294
 None
 1.11A 4x1kD-2po4A:
undetectable		 4x1kD-2po4A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q74 INOSITOL-1-MONOPHOSP
HATASE

(Mycobacterium
tuberculosis) 		PF00459
(Inositol_P) 		5 LEU A  18
LEU A  11
LYS A  98
ALA A 125
ILE A  80
 None
 1.15A 4x1kD-2q74A:
undetectable		 4x1kD-2q74A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ux8 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE

(Sphingomonas
elodea) 		PF00483
(NTP_transferase) 		5 LEU A 130
ALA A 118
VAL A  58
ALA A 114
ILE A  56
 None
 1.08A 4x1kD-2ux8A:
undetectable		 4x1kD-2ux8A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhf UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE CYLD

(Homo sapiens) 		PF00443
(UCH) 		5 CYH A 609
LEU A 610
LEU A 865
ALA A 874
ILE A 594
 None
 1.09A 4x1kD-2vhfA:
undetectable		 4x1kD-2vhfA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w21 GLUTAMATE 5-KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		5 LEU A 155
LEU A 121
ALA A 162
VAL A   8
ILE A 229
 None
 1.19A 4x1kD-2w21A:
undetectable		 4x1kD-2w21A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyx BETA-LACTAMSE TOHO-1

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		5 LEU A 119
ASN A 136
ALA A 109
ALA A 125
ILE A  97
 None
 1.10A 4x1kD-2wyxA:
undetectable		 4x1kD-2wyxA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 LEU A 688
LEU A 598
THR A 724
ALA A 715
ILE A  79
 None
PGR  A1742 (-4.0A)
None
None
None
 1.14A 4x1kD-2xe4A:
undetectable		 4x1kD-2xe4A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 201
LEU A 208
THR A 277
VAL A 146
ALA A 103
 None
 1.11A 4x1kD-2xikA:
undetectable		 4x1kD-2xikA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1

(Homo sapiens) 		PF02144
(Rad1) 		5 LEU C  90
LEU C  27
ALA C  63
VAL C  51
ILE C  34
 None
 1.16A 4x1kD-3a1jC:
undetectable		 4x1kD-3a1jC:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhg ADENYLOSUCCINATE
LYASE

(Legionella
pneumophila) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 LEU A  32
THR A 122
VAL A  96
ALA A  95
ILE A 126
 None
 1.08A 4x1kD-3bhgA:
undetectable		 4x1kD-3bhgA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		5 LEU A 374
ASN A 378
ALA A 358
ALA A 333
ILE A 360
 None
 1.04A 4x1kD-3bz5A:
undetectable		 4x1kD-3bz5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0d PUTATIVE NITRITE
REDUCTASE NADPH
(SMALL SUBUNIT)
OXIDOREDUCTASE
PROTEIN

(Vibrio
parahaemolyticus) 		PF13806
(Rieske_2) 		5 CYH A  10
LEU A  15
THR A  95
VAL A  23
ILE A  25
 None
 1.17A 4x1kD-3c0dA:
undetectable		 4x1kD-3c0dA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da8 PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN

(Mycobacterium
tuberculosis) 		PF00551
(Formyl_trans_N) 		5 LEU A  26
THR A  85
ALA A  43
VAL A  61
ALA A  56
 IOD  A 603 (-4.8A)
None
None
None
None
 1.17A 4x1kD-3da8A:
undetectable		 4x1kD-3da8A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj4 MUCONATE
CYCLOISOMERASE

(Pseudomonas
protegens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 130
LEU A 321
THR A 303
ALA A 289
ILE A 276
 None
None
MUC  A 383 (-4.6A)
None
None
 1.16A 4x1kD-3fj4A:
undetectable		 4x1kD-3fj4A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7m XYLANASE INHIBITOR
TL-XI

(Triticum
aestivum) 		PF00314
(Thaumatin) 		5 MET A 111
THR A  85
ALA A  87
VAL A  89
ILE A  48
 None
 1.03A 4x1kD-3g7mA:
undetectable		 4x1kD-3g7mA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3goa 3-KETOACYL-COA
THIOLASE

(Salmonella
enterica) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ASN A  71
THR A  86
ALA A  84
VAL A  82
ILE A  53
 None
 0.98A 4x1kD-3goaA:
undetectable		 4x1kD-3goaA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4u ATP-DEPENDENT RNA
HELICASE DHX8

(Homo sapiens) 		PF04408
(HA2)
PF07717
(OB_NTP_bind) 		5 CYH A1108
LEU A1173
VAL A1150
LYS A1117
ALA A1115
 None
 1.17A 4x1kD-3i4uA:
undetectable		 4x1kD-3i4uA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipr PTS SYSTEM, IIA
COMPONENT

(Enterococcus
faecalis) 		PF03610
(EIIA-man) 		5 LEU A 103
ASN A  98
ALA A  16
ALA A  20
ILE A   6
 None
 1.11A 4x1kD-3iprA:
3.7		 4x1kD-3iprA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k53 FERROUS IRON
TRANSPORT PROTEIN B

(Pyrococcus
furiosus) 		PF02421
(FeoB_N) 		5 ASN A  81
THR A   5
ALA A   7
VAL A   9
ILE A  85
 None
 0.96A 4x1kD-3k53A:
undetectable		 4x1kD-3k53A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mha LIPOPROTEIN LPRG

(Mycobacterium
tuberculosis) 		PF07161
(LppX_LprAFG) 		5 LEU A 111
THR A 116
ALA A 102
VAL A  91
ILE A 100
 Z69  A   1 ( 4.8A)
None
Z69  A   1 ( 4.9A)
Z69  A   1 (-4.8A)
None
 1.00A 4x1kD-3mhaA:
undetectable		 4x1kD-3mhaA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 480
LEU A 487
ALA A 200
VAL A 170
ALA A 174
 None
 1.10A 4x1kD-3pm0A:
undetectable		 4x1kD-3pm0A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6k RESPONSE REGULATOR
RECEIVER

(Chloroflexus
aurantiacus) 		PF00072
(Response_reg) 		5 LYS A  45
ASN A  46
THR A   5
VAL A   9
ALA A  33
 None
None
SO4  A 137 (-3.0A)
None
None
 1.10A 4x1kD-3t6kA:
undetectable		 4x1kD-3t6kA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx8 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Corynebacterium
glutamicum) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 LEU A 112
THR A  64
ALA A  62
VAL A  60
ALA A 132
 None
 1.16A 4x1kD-3tx8A:
2.7		 4x1kD-3tx8A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcy UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aliivibrio
fischeri) 		PF00275
(EPSP_synthase) 		5 LEU A 267
ALA A 242
VAL A 245
ALA A 244
ILE A 379
 None
 1.04A 4x1kD-3vcyA:
undetectable		 4x1kD-3vcyA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		5 LEU A 405
ALA A 347
VAL A 351
ALA A 981
ILE A 348
 None
 1.17A 4x1kD-3w9hA:
undetectable		 4x1kD-3w9hA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A

(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 LEU A 309
THR A 327
ALA A 325
VAL A 323
ILE A 280
 LEU  A 309 ( 0.6A)
THR  A 327 ( 0.8A)
ALA  A 325 ( 0.0A)
VAL  A 323 ( 0.6A)
ILE  A 280 ( 0.7A)
 1.09A 4x1kD-3whlA:
undetectable		 4x1kD-3whlA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxf UNCHARACTERIZED
PROTEIN

(Danio rerio) 		PF00443
(UCH) 		5 CYH A 604
LEU A 605
LEU A 795
ALA A 804
ILE A 589
 None
 1.19A 4x1kD-3wxfA:
undetectable		 4x1kD-3wxfA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zny CTX-M-12A ENZYME

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		5 LEU A 119
ASN A 136
ALA A 109
ALA A 125
ILE A  97
 None
 1.16A 4x1kD-3znyA:
undetectable		 4x1kD-3znyA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a25 FERRITIN DPS FAMILY
PROTEIN

(Kineococcus
radiotolerans) 		PF00210
(Ferritin) 		5 LEU A  40
LEU A  63
ALA A 116
VAL A 103
ALA A  47
 None
 1.19A 4x1kD-4a25A:
undetectable		 4x1kD-4a25A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX ALPHA-CHAIN
FADB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		5 LEU A 290
THR A 154
ALA A 267
ALA A 263
ILE A 282
 None
 1.08A 4x1kD-4b3iA:
undetectable		 4x1kD-4b3iA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Trypanosoma
brucei) 		PF01704
(UDPGP) 		5 LEU A 515
LEU A 522
ALA A 498
LYS A 497
ILE A 500
 None
 1.09A 4x1kD-4bqhA:
undetectable		 4x1kD-4bqhA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4con ANAEROBIC
RIBONUCLEOSIDE-TRIPH
OSPHATE REDUCTASE

(Thermotoga
maritima) 		PF13597
(NRDD) 		5 LEU A  83
VAL A 408
LYS A 403
ALA A 407
ILE A 372
 None
 0.96A 4x1kD-4conA:
undetectable		 4x1kD-4conA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhe PROBABLE GTP-BINDING
PROTEIN ENGB

(Burkholderia
thailandensis) 		PF01926
(MMR_HSR1) 		5 CYH A  46
LEU A  51
ASN A  65
VAL A  69
ALA A   8
 None
 1.12A 4x1kD-4dheA:
3.5		 4x1kD-4dheA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fid G PROTEIN ALPHA
SUBUNIT

(Entamoeba
histolytica) 		PF00503
(G-alpha) 		5 LEU A 250
ASN A 347
MET A 348
VAL A  26
ILE A  24
 None
 1.10A 4x1kD-4fidA:
5.6		 4x1kD-4fidA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxq PUTATIVE
ADP-RIBOSYLTRANSFERA
SE CERTHRAX

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox)
PF07737
(ATLF) 		5 LEU A 210
ALA A 138
VAL A 142
ALA A 214
ILE A 139
 None
 1.15A 4x1kD-4fxqA:
undetectable		 4x1kD-4fxqA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT

(Escherichia
coli) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 ASN A 160
THR A 393
VAL A 220
ALA A 170
ILE A 228
 None
 1.04A 4x1kD-4g38A:
undetectable		 4x1kD-4g38A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3u ALDEHYDE
DEHYDROGENASE (NAD+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		5 LEU A 202
ASN A 175
ALA A 171
VAL A 168
ILE A 151
 None
 1.18A 4x1kD-4i3uA:
undetectable		 4x1kD-4i3uA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9w PROLINE RACEMASE
FAMILY PROTEIN

(Pseudomonas
protegens) 		PF05544
(Pro_racemase) 		5 CYH A 246
LEU A 247
LEU A 166
ALA A 136
ALA A 158
 None
 1.07A 4x1kD-4j9wA:
undetectable		 4x1kD-4j9wA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knw N-ACYLNEURAMINATE-9-
PHOSPHATASE

(Homo sapiens) 		PF13419
(HAD_2) 		5 CYH A  98
LEU A 101
LEU A  94
ALA A  47
ILE A  34
 None
 1.02A 4x1kD-4knwA:
3.8		 4x1kD-4knwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0x CHLOROMUCONATE
CYCLOISOMERASE

(Rhodococcus
opacus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  74
THR A  52
ALA A  50
VAL A  36
ALA A  10
 None
 1.01A 4x1kD-4m0xA:
3.7		 4x1kD-4m0xA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx2 ADENYLOSUCCINATE
LYASE

(Leishmania
donovani) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		5 LEU A  57
THR A 148
VAL A 123
ALA A 122
ILE A 152
 None
 1.11A 4x1kD-4mx2A:
undetectable		 4x1kD-4mx2A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n8y PUTATIVE TRAP-TYPE
C4-DICARBOXYLATE
TRANSPORT SYSTEM,
BINDING PERIPLASMIC
PROTEIN (DCTP
SUBUNIT)

(Bradyrhizobium
sp. BTAi1) 		PF03480
(DctP) 		5 LEU A 126
MET A  84
THR A  72
VAL A  95
ALA A 132
 None
 1.09A 4x1kD-4n8yA:
undetectable		 4x1kD-4n8yA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf2 ORNITHINE
CARBAMOYLTRANSFERASE

(Bacillus
anthracis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ASN A 222
ALA A 159
VAL A 161
ALA A 185
ILE A 227
 None
 1.04A 4x1kD-4nf2A:
undetectable		 4x1kD-4nf2A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Geobacter
sulfurreducens) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 LEU A 975
THR A 730
ALA A 728
ALA A 648
ILE A 757
 None
 1.10A 4x1kD-4nmeA:
undetectable		 4x1kD-4nmeA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojz PUTATIVE ALGINATE
LYASE

(Saccharophagus
degradans) 		PF05426
(Alginate_lyase)
PF07940
(Hepar_II_III) 		5 THR A 352
VAL A 362
LYS A 357
ALA A 361
ILE A 349
 None
 1.16A 4x1kD-4ojzA:
undetectable		 4x1kD-4ojzA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Shewanella
benthica) 		PF00701
(DHDPS) 		5 LEU A 282
ALA A 289
LYS A 287
ALA A 285
ILE A 236
 None
 1.13A 4x1kD-4pfmA:
2.2		 4x1kD-4pfmA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q60 PROLINE RACEMASE

(Burkholderia
multivorans) 		PF05544
(Pro_racemase) 		5 CYH A 247
LEU A 248
LEU A 167
ALA A 137
ALA A 159
 None
 1.09A 4x1kD-4q60A:
undetectable		 4x1kD-4q60A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5c LEUCINE RICH REPEAT
PROTEIN

(synthetic
construct) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 147
LEU A 192
ASN A 186
THR A 184
VAL A 199
 None
 1.16A 4x1kD-4r5cA:
undetectable		 4x1kD-4r5cA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv4 OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Bacillus
anthracis) 		PF00156
(Pribosyltran) 		5 LEU A 136
VAL A 166
LYS A 160
ALA A 164
ILE A 146
 None
 1.19A 4x1kD-4rv4A:
undetectable		 4x1kD-4rv4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4e THIOLASE

(Sphaerobacter
thermophilus) 		PF02803
(Thiolase_C) 		5 LEU A  53
ALA A  91
VAL A 216
ALA A 102
ILE A 232
 None
 1.04A 4x1kD-4u4eA:
undetectable		 4x1kD-4u4eA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9p UPF0264 PROTEIN
MJ1099

(Methanocaldococcus
jannaschii) 		PF04476
(4HFCP_synth) 		5 LEU A  34
ALA A 184
VAL A 118
ALA A 120
ILE A 204
 None
 1.06A 4x1kD-4u9pA:
undetectable		 4x1kD-4u9pA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9p UPF0264 PROTEIN
MJ1099

(Methanocaldococcus
jannaschii) 		PF04476
(4HFCP_synth) 		5 THR A 202
ALA A 184
VAL A 118
ALA A 120
ILE A 204
 None
 1.12A 4x1kD-4u9pA:
undetectable		 4x1kD-4u9pA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04101
(Glyco_tran_28_C)
PF06925
(MGDG_synth) 		5 LEU A 493
MET A 421
ALA A 439
ALA A 500
ILE A 427
 None
 1.16A 4x1kD-4wyiA:
3.9		 4x1kD-4wyiA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b37 TRYPTOPHAN
DEHYDROGENASE

(Nostoc
punctiforme) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 CYH A 233
LEU A 184
ALA A 173
ALA A 231
ILE A 222
 None
 1.11A 4x1kD-5b37A:
undetectable		 4x1kD-5b37A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5x AQUAPORIN-5

(Homo sapiens) 		PF00230
(MIP) 		5 LEU A  29
ASN A 120
ALA A 193
VAL A 195
ALA A 102
 None
 1.16A 4x1kD-5c5xA:
undetectable		 4x1kD-5c5xA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		5 LEU A 277
LEU A 287
ALA A 294
VAL A 314
ALA A 290
 None
 1.12A 4x1kD-5e78A:
undetectable		 4x1kD-5e78A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE

(Pyrococcus
horikoshii) 		PF00004
(AAA) 		5 LEU A 234
THR A 252
ALA A 250
VAL A 248
ILE A 205
 None
 1.12A 4x1kD-5eqtA:
undetectable		 4x1kD-5eqtA:
22.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 MET A 257
THR A 311
ALA A 313
ALA A 351
ILE A 367
 None
 0.62A 4x1kD-5mjsA:
53.1		 4x1kD-5mjsA:
58.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 6 LEU B 252
THR B 314
ALA B 316
VAL B 318
ALA B 354
ILE B 378
 None
 1.00A 4x1kD-5n5nB:
53.4		 4x1kD-5n5nB:
97.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 LYS B 254
ASN B 258
MET B 259
THR B 314
ILE B 378
 None
 0.80A 4x1kD-5n5nB:
53.4		 4x1kD-5n5nB:
97.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 6 MET B 259
THR B 314
ALA B 316
VAL B 318
ALA B 354
ILE B 378
 None
 0.72A 4x1kD-5n5nB:
53.4		 4x1kD-5n5nB:
97.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oki SISTER CHROMATID
COHESION PROTEIN
DCC1

(Saccharomyces
cerevisiae) 		no annotation 5 LEU C 193
LEU C 201
VAL C 215
ALA C 214
ILE C 231
 None
 1.17A 4x1kD-5okiC:
undetectable		 4x1kD-5okiC:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2u OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 LEU A 113
ASN A 131
VAL A  76
ALA A 117
ILE A  78
 None
 1.19A 4x1kD-5t2uA:
6.7		 4x1kD-5t2uA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t67 SUGAR 3-C-METHYL
TRANSFERASE

(Actinomadura
kijaniata) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		5 LEU A 185
ASN A 177
ALA A 175
VAL A 202
ILE A 112
 None
SAH  A 502 ( 3.7A)
None
None
SAH  A 502 (-4.4A)
 1.09A 4x1kD-5t67A:
2.1		 4x1kD-5t67A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ASN A 508
THR A 419
ALA A 421
ALA A 466
ILE A 512
 None
 1.14A 4x1kD-5tf0A:
undetectable		 4x1kD-5tf0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkq NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L

(Drosophila
melanogaster) 		PF00023
(Ank)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU A 454
ALA A 437
VAL A 427
ALA A 458
ILE A 405
 None
 1.13A 4x1kD-5vkqA:
undetectable		 4x1kD-5vkqA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc1 MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1

(Caenorhabditis
elegans) 		PF00004
(AAA) 		6 LEU A 318
THR A 339
ALA A 337
VAL A 335
ALA A 228
ILE A 291
 None
 1.14A 4x1kD-5wc1A:
undetectable		 4x1kD-5wc1A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE

(Geobacillus sp.
12AMOR1) 		no annotation 5 LEU A 221
LEU A 218
THR A 103
ALA A 121
ALA A 204
 None
 1.11A 4x1kD-5xksA:
undetectable		 4x1kD-5xksA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E

(Mus musculus) 		no annotation 5 LEU A 886
LEU A 865
ALA A 872
VAL A 809
ALA A 868
 None
 1.18A 4x1kD-5yudA:
undetectable		 4x1kD-5yudA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6at7 PHENYLALANINE
AMMONIA-LYASE

(Sorghum bicolor) 		no annotation 5 ASN A 525
ALA A 622
VAL A 626
ALA A 631
ILE A 519
 None
 1.17A 4x1kD-6at7A:
undetectable		 4x1kD-6at7A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5c KATANIN P60
ATPASE-CONTAINING
SUBUNIT A-LIKE 1

(Homo sapiens) 		no annotation 5 LEU A 333
THR A 358
ALA A 356
VAL A 354
ILE A 306
 None
 1.16A 4x1kD-6b5cA:
undetectable		 4x1kD-6b5cA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5d MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1

(Caenorhabditis
elegans) 		no annotation 5 LEU A 318
ALA A 337
VAL A 335
ALA A 228
ILE A 291
 None
 0.73A 4x1kD-6b5dA:
undetectable		 4x1kD-6b5dA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5d MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1

(Caenorhabditis
elegans) 		no annotation 5 THR A 339
ALA A 337
VAL A 335
ALA A 228
ILE A 291
 None
 0.87A 4x1kD-6b5dA:
undetectable		 4x1kD-6b5dA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bu3 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 5 LEU A 119
ASN A 136
ALA A 109
ALA A 125
ILE A  97
 None
 1.13A 4x1kD-6bu3A:
undetectable		 4x1kD-6bu3A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e29 -

(-) 		no annotation 5 LEU D  92
LEU D  95
ASN D  33
ALA D  40
VAL D  48
 None
 1.14A 4x1kD-6e29D:
undetectable		 4x1kD-6e29D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esl BACTERIAL LEUCYL
AMINOPEPTIDASE

(Legionella
pneumophila) 		no annotation 5 LEU A 300
ALA A 264
VAL A 266
ALA A 332
ILE A 189
 None
 0.92A 4x1kD-6eslA:
3.3		 4x1kD-6eslA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARD

(Acetobacterium
woodii) 		no annotation 5 CYH B  74
LEU B  34
ASN B  40
VAL B  59
ALA B   7
 None
 0.89A 4x1kD-6fahB:
undetectable		 4x1kD-6fahB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbg OUTER MEMBRANE
PROTEIN

(Helicobacter
pylori) 		no annotation 5 LEU A 173
LEU A 182
ALA A 287
ALA A 220
ILE A 284
 None
 1.07A 4x1kD-6gbgA:
undetectable		 4x1kD-6gbgA:
13.60