SIMILAR PATTERNS OF AMINO ACIDS FOR 4X1I_D_LOCD502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkh MUCONATE LACTONIZING
ENZYME

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 128
LEU A 319
THR A 301
ALA A 287
ILE A 274
 None
 1.14A 4x1iD-1bkhA:
4.0		 4x1iD-1bkhA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bud PROTEIN (ACUTOLYSIN
A)

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		5 LEU A  47
LEU A 148
ASN A 147
MET A 116
ILE A 198
 None
 1.03A 4x1iD-1budA:
undetectable		 4x1iD-1budA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h6h NEUTROPHIL CYTOSOL
FACTOR 4

(Homo sapiens) 		PF00787
(PX) 		5 LEU A 117
ASN A  25
LYS A  46
ALA A  21
ILE A  55
 None
 0.97A 4x1iD-1h6hA:
undetectable		 4x1iD-1h6hA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htd ATROLYSIN C

(Crotalus atrox) 		PF01421
(Reprolysin) 		5 LEU A  47
LEU A 148
ASN A 147
MET A 116
ILE A 198
 None
 1.02A 4x1iD-1htdA:
undetectable		 4x1iD-1htdA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1izo CYTOCHROME P450
152A1

(Bacillus
subtilis) 		PF00067
(p450) 		5 LEU A 241
LEU A 102
LEU A 214
ALA A 218
ILE A 198
 None
 1.06A 4x1iD-1izoA:
undetectable		 4x1iD-1izoA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kug METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		5 CYH A  46
LEU A  49
LEU A 150
MET A 118
ILE A 199
 None
 1.11A 4x1iD-1kugA:
undetectable		 4x1iD-1kugA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION

(Bacillus
subtilis) 		PF01256
(Carb_kinase) 		5 CYH A 227
LEU A  55
ALA A 100
ALA A  30
ILE A 126
 None
 1.15A 4x1iD-1kyhA:
2.5		 4x1iD-1kyhA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lva SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR

(Moorella
thermoacetica) 		PF09105
(SelB-wing_1)
PF09106
(SelB-wing_2)
PF09107
(SelB-wing_3) 		5 LYS A 412
LEU A 414
MET A 417
ALA A 403
ILE A 387
 None
 1.16A 4x1iD-1lvaA:
undetectable		 4x1iD-1lvaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A

(Thermobifida
fusca) 		PF00079
(Serpin) 		5 LEU A 145
THR A 298
ALA A 319
ALA A 317
ILE A 157
 None
 0.78A 4x1iD-1mtpA:
undetectable		 4x1iD-1mtpA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		5 LEU A 386
ASN A 420
THR A 489
ALA A 506
ALA A 279
 None
 1.12A 4x1iD-1t6pA:
undetectable		 4x1iD-1t6pA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8d HYPOTHETICAL PROTEIN
(TT1679)

(Thermus
thermophilus) 		PF04260
(DUF436) 		5 LEU A  93
LEU A 100
LEU A  68
ALA A  51
ILE A 173
 None
 0.95A 4x1iD-1v8dA:
undetectable		 4x1iD-1v8dA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8d HYPOTHETICAL PROTEIN
(TT1679)

(Thermus
thermophilus) 		PF04260
(DUF436) 		5 LEU A 191
LEU A  55
MET A  60
LYS A 205
ALA A 203
 None
 1.11A 4x1iD-1v8dA:
undetectable		 4x1iD-1v8dA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG

(Mus musculus) 		PF00225
(Kinesin) 		5 MET A  81
ALA A 326
LYS A   7
ALA A   9
ILE A  93
 None
 1.11A 4x1iD-1vfwA:
undetectable		 4x1iD-1vfwA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wni TRIMERELYSIN II

(Protobothrops
flavoviridis) 		PF01421
(Reprolysin) 		5 LEU A  47
LEU A 148
ASN A 147
MET A 116
ILE A 197
 None
 1.05A 4x1iD-1wniA:
undetectable		 4x1iD-1wniA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp1 FII

(Deinagkistrodon
acutus) 		PF01421
(Reprolysin) 		5 LEU A  47
LEU A 148
ASN A 147
MET A 116
ILE A 197
 None
 0.99A 4x1iD-1yp1A:
undetectable		 4x1iD-1yp1A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z9d URIDYLATE KINASE

(Streptococcus
pyogenes) 		PF00696
(AA_kinase) 		5 LEU A  11
LEU A  51
MET A  89
ALA A 162
ILE A  39
 None
 1.06A 4x1iD-1z9dA:
undetectable		 4x1iD-1z9dA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amh SEPTUM FORMATION
PROTEIN MAF
HOMOLOGUE, PUTATIVE

(Trypanosoma
brucei) 		PF02545
(Maf) 		5 LEU A  69
MET A  65
THR A  87
ALA A  85
ILE A  13
 None
 1.16A 4x1iD-2amhA:
undetectable		 4x1iD-2amhA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buc DIPEPTIDYL PEPTIDASE
IV

(Sus scrofa) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 LEU A 410
LEU A 436
ASN A 437
LYS A 441
ILE A 397
 None
 0.90A 4x1iD-2bucA:
undetectable		 4x1iD-2bucA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t 3-KETOACYL-COA
THIOLASE
FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT

(Pseudomonas
fragi) 		PF00108
(Thiolase_N)
PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
PF02803
(Thiolase_C) 		5 LEU C 142
LEU A 223
ASN A 264
ALA A 233
ILE A 259
 None
 1.06A 4x1iD-2d3tC:
undetectable		 4x1iD-2d3tC:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2daj KIAA0977 PROTEIN

(Homo sapiens) 		PF09469
(Cobl) 		5 LEU A  72
LYS A  55
LEU A  77
THR A  51
ILE A  40
 None
 1.11A 4x1iD-2dajA:
undetectable		 4x1iD-2dajA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B

(Homo sapiens) 		PF14580
(LRR_9) 		5 LEU A 113
LEU A 122
LEU A 102
ASN A 101
ILE A  83
 None
 1.05A 4x1iD-2ellA:
undetectable		 4x1iD-2ellA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B

(Homo sapiens) 		PF14580
(LRR_9) 		5 LEU A 116
LEU A  97
LEU A 102
ASN A 101
ILE A  83
 None
 1.08A 4x1iD-2ellA:
undetectable		 4x1iD-2ellA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		5 LEU A 185
LEU A 292
MET A 295
ALA A 282
ILE A 278
 None
 0.95A 4x1iD-2fj0A:
2.6		 4x1iD-2fj0A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m1x TIR
DOMAIN-CONTAINING
ADAPTER MOLECULE 1

(Homo sapiens) 		no annotation 5 LEU A 533
LEU A 416
THR A 426
ALA A 450
ILE A 453
 None
 0.93A 4x1iD-2m1xA:
undetectable		 4x1iD-2m1xA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m45 MINICHROMOSOME
MAINTENANCE PROTEIN
MCM

(Sulfolobus
solfataricus) 		no annotation 5 LEU A 649
LYS A 664
LEU A 666
MET A 669
ILE A 633
 None
 1.06A 4x1iD-2m45A:
undetectable		 4x1iD-2m45A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m45 MINICHROMOSOME
MAINTENANCE PROTEIN
MCM

(Sulfolobus
solfataricus) 		no annotation 5 LYS A 664
LEU A 666
MET A 669
ALA A 652
ILE A 633
 None
 1.12A 4x1iD-2m45A:
undetectable		 4x1iD-2m45A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU X 257
LYS X 299
LEU X 301
ALA X 163
ILE X 325
 None
 1.12A 4x1iD-2p3gX:
undetectable		 4x1iD-2p3gX:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9v SELENOCYSTEINE-SPECI
FIC ELONGATION
FACTOR

(Moorella
thermoacetica) 		PF09105
(SelB-wing_1)
PF09106
(SelB-wing_2) 		5 LEU A 432
LEU A 414
MET A 417
ALA A 400
ILE A 387
 None
 0.97A 4x1iD-2v9vA:
undetectable		 4x1iD-2v9vA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyx BETA-LACTAMSE TOHO-1

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		5 LEU A 119
ASN A 136
ALA A 109
ALA A 125
ILE A  97
 None
 1.11A 4x1iD-2wyxA:
undetectable		 4x1iD-2wyxA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2d CD180 ANTIGEN

(Homo sapiens) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 377
LEU A 395
LEU A 350
ALA A 341
ILE A 339
 None
 1.03A 4x1iD-3b2dA:
undetectable		 4x1iD-3b2dA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47

(Homo sapiens) 		PF00270
(DEAD) 		5 LEU A 192
LEU A 220
LEU A 215
ALA A 176
ILE A 179
 PGE  A 401 (-3.9A)
None
None
None
None
 1.09A 4x1iD-3berA:
2.5		 4x1iD-3berA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		5 LEU A 374
ASN A 378
ALA A 358
ALA A 333
ILE A 360
 None
 1.01A 4x1iD-3bz5A:
undetectable		 4x1iD-3bz5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsl ZINC
METALLOPROTEINASE-DI
SINTEGRIN
BOTHROPASIN

(Bothrops
jararaca) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		6 LEU A  50
LEU A 151
ASN A 150
MET A 119
ALA A  54
ILE A 201
 None
 1.15A 4x1iD-3dslA:
undetectable		 4x1iD-3dslA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eh1 PROTEIN TRANSPORT
PROTEIN SEC24B

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 LEU A1021
LEU A 964
THR A 946
ALA A 961
ILE A 926
 None
 1.11A 4x1iD-3eh1A:
4.9		 4x1iD-3eh1A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdu PUTATIVE ENOYL-COA
HYDRATASE/ISOMERASE

(Acinetobacter
baumannii) 		PF00378
(ECH_1) 		5 LEU A  47
LEU A  22
LEU A  61
ALA A  15
ILE A  26
 None
 0.91A 4x1iD-3fduA:
undetectable		 4x1iD-3fduA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbo ZINC
METALLOPROTEINASE
BMOOMPALFA-I

(Bothrops
moojeni) 		PF01421
(Reprolysin) 		5 LEU A 146
ASN A 145
MET A 114
ALA A  49
ILE A 196
 None
 1.01A 4x1iD-3gboA:
undetectable		 4x1iD-3gboA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1g CHEMOTAXIS PROTEIN
CHEY HOMOLOG

(Helicobacter
pylori) 		PF00072
(Response_reg) 		5 LEU A  64
LYS A  40
LEU A  41
ASN A  44
ILE A  77
 None
 1.06A 4x1iD-3h1gA:
5.4		 4x1iD-3h1gA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igs N-ACETYLMANNOSAMINE-
6-PHOSPHATE
2-EPIMERASE 2

(Salmonella
enterica) 		PF04131
(NanE) 		5 LEU A   3
ASN A  10
ALA A  49
ALA A 100
ILE A  18
 None
 1.12A 4x1iD-3igsA:
undetectable		 4x1iD-3igsA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4s FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		5 LEU A 388
LEU A 183
THR A 143
ALA A 137
ILE A 166
 None
 1.13A 4x1iD-3j4sA:
20.4		 4x1iD-3j4sA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jux PROTEIN TRANSLOCASE
SUBUNIT SECA

(Thermotoga
maritima) 		PF00271
(Helicase_C)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		5 LYS A 162
ASN A 163
ALA A 170
ALA A 196
ILE A 171
 None
 1.15A 4x1iD-3juxA:
2.1		 4x1iD-3juxA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3klb PUTATIVE
FLAVOPROTEIN

(Bacteroides
fragilis) 		PF12682
(Flavodoxin_4) 		5 LEU A 128
ASN A 127
ALA A  92
ALA A 114
ILE A  96
 None
 1.09A 4x1iD-3klbA:
4.2		 4x1iD-3klbA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzv UNCHARACTERIZED
OXIDOREDUCTASE
YIR035C

(Saccharomyces
cerevisiae) 		PF00106
(adh_short) 		5 LEU A 117
LEU A 125
LEU A   6
ALA A  72
LYS A  78
 None
 1.11A 4x1iD-3kzvA:
5.8		 4x1iD-3kzvA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1t PUTATIVE
PHOSPHOHYDROLASE

(Shewanella
amazonensis) 		PF08668
(HDOD) 		5 LEU A  13
LEU A  16
LYS A 189
THR A 132
ALA A  93
 None
 1.14A 4x1iD-3m1tA:
undetectable		 4x1iD-3m1tA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrw PHAGE
INTEGRASE/SITE-SPECI
FIC RECOMBINASE

(Haloarcula
marismortui) 		PF13102
(Phage_int_SAM_5) 		5 LEU A  83
LEU A  90
LEU A  54
ALA A  12
ILE A  48
 None
 1.08A 4x1iD-3nrwA:
undetectable		 4x1iD-3nrwA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyy PUTATIVE
GLYCYL-GLYCINE
ENDOPEPTIDASE LYTM

([Ruminococcus]
gnavus) 		PF01551
(Peptidase_M23) 		5 LYS A 251
LEU A 250
ALA A 113
ALA A 194
ILE A 114
 2PE  A 281 (-2.9A)
None
None
None
None
 1.04A 4x1iD-3nyyA:
undetectable		 4x1iD-3nyyA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouh EGL NINE HOMOLOG 1

(Homo sapiens) 		PF13640
(2OG-FeII_Oxy_3) 		5 LEU A 271
THR A 257
ALA A 298
LYS A 297
ILE A 386
 None
 1.10A 4x1iD-3ouhA:
undetectable		 4x1iD-3ouhA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rg1 CD180 MOLECULE

(Bos taurus) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 377
LEU A 395
LEU A 350
ALA A 341
ILE A 339
 None
 1.06A 4x1iD-3rg1A:
undetectable		 4x1iD-3rg1A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF00982
(Glyco_transf_20) 		5 LEU A 313
LEU A 375
ALA A 432
ALA A 307
ILE A 403
 None
 1.09A 4x1iD-3t5tA:
3.2		 4x1iD-3t5tA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6g SH2
DOMAIN-CONTAINING
PROTEIN 3C

(Homo sapiens) 		PF00617
(RasGEF) 		5 LEU A 507
LEU A 535
LEU A 490
MET A 486
ALA A 515
 None
 1.14A 4x1iD-3t6gA:
undetectable		 4x1iD-3t6gA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q CD180 ANTIGEN

(Mus musculus) 		PF13855
(LRR_8) 		5 LEU A 377
LEU A 395
LEU A 350
ALA A 341
ILE A 339
 None
 1.02A 4x1iD-3t6qA:
undetectable		 4x1iD-3t6qA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8v RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L

(Escherichia
coli) 		PF01170
(UPF0020)
PF02926
(THUMP)
PF10672
(Methyltrans_SAM) 		5 LEU A  43
LEU A  20
THR A   8
ALA A   6
ILE A  57
 None
 1.13A 4x1iD-3v8vA:
3.4		 4x1iD-3v8vA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsv XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF13229
(Beta_helix) 		5 LEU A 628
LEU A 437
ASN A 436
ALA A 531
ILE A 481
 None
 1.06A 4x1iD-3vsvA:
undetectable		 4x1iD-3vsvA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zny CTX-M-12A ENZYME

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		5 LEU A 119
ASN A 136
ALA A 109
ALA A 125
ILE A  97
 None
 1.15A 4x1iD-3znyA:
undetectable		 4x1iD-3znyA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00202
(Aminotran_3)
PF13500
(AAA_26) 		5 LEU A 271
LYS A 294
LEU A 296
ALA A 244
ILE A 215
 None
 1.10A 4x1iD-4a0hA:
3.9		 4x1iD-4a0hA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aig ADAMALYSIN II

(Crotalus
adamanteus) 		PF01421
(Reprolysin) 		5 LEU A  47
LEU A 148
ASN A 147
MET A 116
ILE A 198
 None
 1.01A 4x1iD-4aigA:
undetectable		 4x1iD-4aigA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akm LYSOSOME-ASSOCIATED
MEMBRANE
GLYCOPROTEIN 3

(Homo sapiens) 		PF01299
(Lamp) 		5 LEU A 360
LEU A 292
ASN A 291
ALA A 270
ILE A 244
 None
None
NAG  A1379 (-2.0A)
None
None
 1.06A 4x1iD-4akmA:
undetectable		 4x1iD-4akmA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqh UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Trypanosoma
brucei) 		PF01704
(UDPGP) 		5 LEU A 515
LEU A 522
ALA A 498
LYS A 497
ILE A 500
 None
 1.10A 4x1iD-4bqhA:
undetectable		 4x1iD-4bqhA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8y CAS6A

(Thermus
thermophilus) 		PF10040
(CRISPR_Cas6) 		5 LEU A 118
LEU A 147
THR A 126
ALA A 234
ALA A 236
 None
 1.11A 4x1iD-4c8yA:
undetectable		 4x1iD-4c8yA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1j GLYCEROL KINASE

(Sinorhizobium
meliloti) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A  29
THR A  81
ALA A  85
ALA A  50
ILE A  86
 None
 1.04A 4x1iD-4e1jA:
undetectable		 4x1iD-4e1jA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h41 PUTATIVE
ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF14488
(DUF4434)
PF17134
(DUF5109) 		5 LEU A 355
LYS A 318
LEU A 319
THR A 298
ILE A  60
 None
 1.10A 4x1iD-4h41A:
3.5		 4x1iD-4h41A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4m ZINC-DEPENDENT
METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		5 LEU A  49
LEU A 150
ASN A 149
MET A 118
ILE A 199
 None
 1.06A 4x1iD-4j4mA:
undetectable		 4x1iD-4j4mA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9w PROLINE RACEMASE
FAMILY PROTEIN

(Pseudomonas
protegens) 		PF05544
(Pro_racemase) 		5 CYH A 246
LEU A 247
LEU A 166
ALA A 136
ALA A 158
 None
 1.14A 4x1iD-4j9wA:
undetectable		 4x1iD-4j9wA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4knw N-ACYLNEURAMINATE-9-
PHOSPHATASE

(Homo sapiens) 		PF13419
(HAD_2) 		5 CYH A  98
LEU A 101
LEU A  94
ALA A  47
ILE A  34
 None
 1.05A 4x1iD-4knwA:
3.9		 4x1iD-4knwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krt AUTOLYTIC LYSOZYME

(Clostridium
phage phiSM101) 		PF01183
(Glyco_hydro_25)
PF08239
(SH3_3) 		5 CYH A 117
LEU A 121
THR A 138
ALA A 141
ILE A 169
 None
 1.14A 4x1iD-4krtA:
undetectable		 4x1iD-4krtA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhl INTERLEUKIN-11

(Homo sapiens) 		PF07400
(IL11) 		5 LEU A  78
LEU A  75
ASN A  71
ALA A 176
ILE A 177
 None
 1.11A 4x1iD-4mhlA:
undetectable		 4x1iD-4mhlA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkv RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Pisum sativum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 280
LEU A 289
ASN A 287
ALA A 257
ALA A 242
 None
 1.05A 4x1iD-4mkvA:
undetectable		 4x1iD-4mkvA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0g PROTEIN PHOSPHATASE
2C 37

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		6 CYH A 321
LEU A 346
LYS A 104
ASN A 360
ALA A 366
ALA A 342
 None
 1.29A 4x1iD-4n0gA:
undetectable		 4x1iD-4n0gA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0g PROTEIN PHOSPHATASE
2C 37

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		6 CYH A 321
LEU A 389
LEU A 346
LYS A 104
ASN A 360
ALA A 342
 None
 1.49A 4x1iD-4n0gA:
undetectable		 4x1iD-4n0gA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfm 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Shewanella
benthica) 		PF00701
(DHDPS) 		5 LEU A 282
ALA A 289
LYS A 287
ALA A 285
ILE A 236
 None
 1.07A 4x1iD-4pfmA:
3.0		 4x1iD-4pfmA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7z CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus) 		PF00493
(MCM) 		5 LEU A 325
LEU A 338
LEU A 761
MET A 764
ILE A 772
 None
 1.09A 4x1iD-4r7zA:
undetectable		 4x1iD-4r7zA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wyi MONOGALACTOSYLDIACYL
GLYCEROL SYNTHASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF04101
(Glyco_tran_28_C)
PF06925
(MGDG_synth) 		5 LEU A 493
MET A 421
ALA A 439
ALA A 500
ILE A 427
 None
 1.16A 4x1iD-4wyiA:
4.0		 4x1iD-4wyiA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Drosophila
melanogaster) 		PF07034
(ORC3_N) 		5 LEU C 292
LEU C 322
ALA C  56
ALA C 289
ILE C  60
 None
 1.13A 4x1iD-4xgcC:
undetectable		 4x1iD-4xgcC:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3

(Mus musculus) 		PF13855
(LRR_8) 		5 LEU B 180
LEU B 227
LEU B 195
ASN B 223
ILE B 190
 None
 1.16A 4x1iD-4yebB:
undetectable		 4x1iD-4yebB:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN

(Helicobacter
pylori) 		no annotation 6 LEU A  73
LEU A 321
LYS A 366
LEU A 368
ALA A  85
ILE A 440
 None
 1.30A 4x1iD-4zh7A:
undetectable		 4x1iD-4zh7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zh7 OUTER MEMBRANE
PROTEIN-ADHESIN

(Helicobacter
pylori) 		no annotation 6 LEU A  73
LEU A 321
LYS A 366
LEU A 368
ASN A 369
ALA A  85
 None
 1.12A 4x1iD-4zh7A:
undetectable		 4x1iD-4zh7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a29 EXOPOLYGALACTURONATE
LYASE

(Vibrio
vulnificus) 		PF06917
(Pectate_lyase_2) 		5 LEU A 360
LEU A 431
ASN A 434
MET A 435
ALA A 366
 None
EDO  A1579 ( 4.3A)
None
None
None
 1.10A 4x1iD-5a29A:
undetectable		 4x1iD-5a29A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9a ADHESIN BINDING
FUCOSYLATED
HISTO-BLOOD GROUP
ANTIGEN,ADHESIN,ADHE
SIN BINDING
FUCOSYLATED
HISTO-BLOOD GROUP
ANTIGEN

(Helicobacter
pylori) 		no annotation 5 LEU A  73
LEU A 315
LEU A 362
ALA A  85
ILE A 434
 None
 1.05A 4x1iD-5f9aA:
undetectable		 4x1iD-5f9aA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ft6 CYSTEINE DESULFURASE
CSDA

(Escherichia
coli) 		PF00266
(Aminotran_5) 		5 LEU A 223
LEU A 289
ALA A 297
ALA A 377
ILE A 294
 None
 1.09A 4x1iD-5ft6A:
undetectable		 4x1iD-5ft6A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gr8 LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE PEPR1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		5 CYH A 338
LEU A 362
LEU A 317
LEU A 344
ILE A 331
 None
 1.15A 4x1iD-5gr8A:
undetectable		 4x1iD-5gr8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ij6 LIPOATE--PROTEIN
LIGASE

(Enterococcus
faecalis) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		5 LEU A 189
LEU A 205
ALA A 108
ALA A 114
ILE A 105
 None
 1.14A 4x1iD-5ij6A:
undetectable		 4x1iD-5ij6A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 LEU B 356
LYS B 374
LEU B 378
ALA B 271
ILE B 282
 None
 1.14A 4x1iD-5ip9B:
undetectable		 4x1iD-5ip9B:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF13193
(AMP-binding_C) 		5 CYH A 731
LEU A 726
LEU A 697
THR A 690
ALA A 760
 None
 1.04A 4x1iD-5ja1A:
undetectable		 4x1iD-5ja1A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE

(Rhodopseudomonas
palustris) 		PF00171
(Aldedh) 		5 LEU A 346
ALA A 355
LYS A 351
ALA A 315
ILE A 404
 None
 1.13A 4x1iD-5jfmA:
undetectable		 4x1iD-5jfmA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjh 4-ALPHA-GLUCANOTRANS
FERASE

(Corynebacterium
glutamicum) 		PF02446
(Glyco_hydro_77) 		5 LEU A 387
LEU A 451
LEU A 494
ALA A 503
ILE A 526
 None
 1.03A 4x1iD-5jjhA:
undetectable		 4x1iD-5jjhA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA

(Escherichia
coli) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5) 		5 LEU A 208
LEU A 266
ALA A 234
ALA A 226
ILE A 271
 None
 1.08A 4x1iD-5lm7A:
undetectable		 4x1iD-5lm7A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdh MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A  64
LEU A  53
LEU A  20
ALA A  11
ALA A  69
 None
 1.05A 4x1iD-5mdhA:
undetectable		 4x1iD-5mdhA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 LEU A 253
MET A 257
THR A 311
ALA A 313
ILE A 367
 None
 0.98A 4x1iD-5mjsA:
53.1		 4x1iD-5mjsA:
58.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mjs TUBULIN BETA CHAIN

(Schizosaccharomyces
pombe) 		no annotation 5 MET A 257
THR A 311
ALA A 313
ALA A 351
ILE A 367
 None
 0.57A 4x1iD-5mjsA:
53.1		 4x1iD-5mjsA:
58.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 LEU B 255
ASN B 258
MET B 259
THR B 314
ILE B 378
 None
 0.80A 4x1iD-5n5nB:
53.4		 4x1iD-5n5nB:
97.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 LEU B 255
MET B 259
THR B 314
ALA B 316
ILE B 378
 None
 0.93A 4x1iD-5n5nB:
53.4		 4x1iD-5n5nB:
97.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 MET B 259
THR B 314
ALA B 316
ALA B 354
ILE B 378
 None
 0.69A 4x1iD-5n5nB:
53.4		 4x1iD-5n5nB:
97.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oo7 SLA2

(Chaetomium
thermophilum) 		no annotation 5 CYH A  39
LEU A  56
ALA A  71
ALA A  23
ILE A  75
 None
 1.16A 4x1iD-5oo7A:
undetectable		 4x1iD-5oo7A:
9.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w3j TUBULIN BETA CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 LEU B 253
ASN B 256
THR B 312
ALA B 314
ILE B 368
 None
 0.75A 4x1iD-5w3jB:
53.3		 4x1iD-5w3jB:
75.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1e ICMO (DOTL)
ICMS
ICMW

(Legionella
pneumophila) 		PF12608
(T4bSS_IcmS)
no annotation 		5 CYH A  50
LEU A  49
LEU A  84
LEU B 131
ALA C 740
 None
 1.09A 4x1iD-5x1eA:
undetectable		 4x1iD-5x1eA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2n -

(-) 		no annotation 5 LYS B  23
LEU B  25
MET B  28
ALA B  13
ILE B  37
 None
 1.13A 4x1iD-5z2nB:
undetectable		 4x1iD-5z2nB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf6 INSULIN-DEGRADING
ENZYME

(Homo sapiens) 		no annotation 6 LEU A 642
LEU A 616
LEU A 574
ASN A 573
LYS A 571
ILE A 733
 None
 1.27A 4x1iD-6bf6A:
undetectable		 4x1iD-6bf6A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bu3 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 5 LEU A 119
ASN A 136
ALA A 109
ALA A 125
ILE A  97
 None
 1.13A 4x1iD-6bu3A:
undetectable		 4x1iD-6bu3A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 10
N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT

(Homo sapiens) 		no annotation 5 LEU A 541
LEU B  11
ASN B  13
MET B  14
ALA B   6
 None
 1.01A 4x1iD-6c9mA:
undetectable		 4x1iD-6c9mA:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cza -

(-) 		no annotation 5 LEU A 173
LEU A 522
LEU A 569
ALA A 505
ILE A 147
 None
 1.14A 4x1iD-6czaA:
2.8		 4x1iD-6czaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbg OUTER MEMBRANE
PROTEIN

(Helicobacter
pylori) 		no annotation 5 LEU A 173
LEU A 182
ALA A 287
ALA A 220
ILE A 284
 None
 1.10A 4x1iD-6gbgA:
undetectable		 4x1iD-6gbgA:
13.60