SIMILAR PATTERNS OF AMINO ACIDS FOR 4X1I_B_LOCB502_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amk TRIOSE PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00121
(TIM) 		5 ALA A 236
ASN A 218
THR A 221
ALA A 248
ALA A   8
 None
 1.19A 4x1iB-1amkA:
undetectable		 4x1iB-1amkA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g65 PROTEASOME COMPONENT
PUP3

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		6 ALA I 158
LEU I 160
MET I 191
ALA I 173
VAL I 175
ALA I  15
 None
 1.36A 4x1iB-1g65I:
undetectable		 4x1iB-1g65I:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqa CYTOCHROME C'

(Rhodobacter
sphaeroides) 		PF01322
(Cytochrom_C_2) 		5 LEU A  97
ALA A 111
MET A  27
ALA A  39
ALA A  43
 None
 1.06A 4x1iB-1gqaA:
undetectable		 4x1iB-1gqaA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ib8 CONSERVED PROTEIN
SP14.3

(Streptococcus
pneumoniae) 		PF02576
(DUF150)
PF17384
(DUF150_C) 		5 LEU A  93
LEU A 133
MET A 135
VAL A 153
ALA A 156
 None
 1.25A 4x1iB-1ib8A:
undetectable		 4x1iB-1ib8A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdi L-RIBULOSE 5
PHOSPHATE
4-EPIMERASE

(Escherichia
coli) 		PF00596
(Aldolase_II) 		5 LEU A 190
ALA A 101
THR A 145
VAL A  94
ALA A 175
 None
 1.00A 4x1iB-1jdiA:
undetectable		 4x1iB-1jdiA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgf P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		6 CYH A 230
LEU A 226
LYS A 102
LEU A 103
THR A 108
VAL A 156
 None
 1.46A 4x1iB-1lgfA:
undetectable		 4x1iB-1lgfA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		5 LEU A  46
THR A 156
ALA A 154
VAL A 152
ALA A  16
 None
 1.27A 4x1iB-1mb9A:
undetectable		 4x1iB-1mb9A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nfi I-KAPPA-B-ALPHA

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU E 237
LEU E 232
ALA E 220
VAL E 209
ALA E 241
 None
 0.98A 4x1iB-1nfiE:
undetectable		 4x1iB-1nfiE:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy3 TRANSCRIPTION FACTOR
INHIBITOR
I-KAPPA-B-BETA

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 LEU D 278
ALA D 298
LEU D 261
VAL D 249
ALA D 281
 None
 1.21A 4x1iB-1oy3D:
undetectable		 4x1iB-1oy3D:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 LEU A  57
ALA A  56
LEU A 106
THR A 179
ALA A  33
 None
 1.21A 4x1iB-1p88A:
undetectable		 4x1iB-1p88A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rw0 CONSERVED
HYPOTHETICAL PROTEIN

(Salmonella
enterica) 		PF02578
(Cu-oxidase_4) 		5 CYH A 113
ALA A 151
LEU A 111
ALA A  17
VAL A  15
 None
 1.13A 4x1iB-1rw0A:
undetectable		 4x1iB-1rw0A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE

(Rhodotorula
toruloides) 		PF00221
(Lyase_aromatic) 		5 LEU A 386
ASN A 420
THR A 489
ALA A 506
ALA A 279
 None
 0.99A 4x1iB-1t6pA:
undetectable		 4x1iB-1t6pA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tcd TRIOSEPHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00121
(TIM) 		5 LEU A 233
THR A  45
ALA A  43
VAL A  41
ALA A  10
 None
 1.19A 4x1iB-1tcdA:
undetectable		 4x1iB-1tcdA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tig TRANSLATION
INITIATION FACTOR 3

(Geobacillus
stearothermophilus) 		PF00707
(IF3_C) 		5 CYH A 144
LEU A 110
ALA A 148
ALA A 118
ALA A 106
 None
 0.82A 4x1iB-1tigA:
undetectable		 4x1iB-1tigA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE

(Thermus
thermophilus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LYS A 186
LEU A 188
ASN A 210
MET A 209
ALA A 218
 None
 1.27A 4x1iB-1ub7A:
undetectable		 4x1iB-1ub7A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8d HYPOTHETICAL PROTEIN
(TT1679)

(Thermus
thermophilus) 		PF04260
(DUF436) 		5 LEU A 191
LEU A  55
MET A  60
LYS A 205
ALA A 203
 None
 1.07A 4x1iB-1v8dA:
undetectable		 4x1iB-1v8dA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfw PROTEIN (FUSION
PROTEIN CONSISTING
OF KINESIN-LIKE
PROTEIN KIF1A,
KINESIN HEAVY CHAIN
ISOFORM 5C AND A HIS
TAG

(Mus musculus) 		PF00225
(Kinesin) 		5 MET A  81
ALA A 326
VAL A 328
LYS A   7
ALA A   9
 None
 1.15A 4x1iB-1vfwA:
undetectable		 4x1iB-1vfwA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wfz NITROGEN FIXATION
CLUSTER-LIKE

(Mus musculus) 		PF01592
(NifU_N) 		5 LEU A 114
ALA A 113
LEU A  39
ALA A  69
ALA A  81
 None
 1.27A 4x1iB-1wfzA:
undetectable		 4x1iB-1wfzA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9e HMG-COA SYNTHASE

(Enterococcus
faecalis) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 ALA A  88
LEU A  92
MET A  96
ALA A  59
ALA A 157
 None
 1.26A 4x1iB-1x9eA:
undetectable		 4x1iB-1x9eA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg0 B-PHYCOERYTHRIN BETA
CHAIN

(Rhodomonas sp.
CS24) 		PF00502
(Phycobilisome) 		5 CYH C  73
LEU C  66
ASN C 125
ALA C 130
VAL C  56
 PEB  C 282 (-3.5A)
PEB  C 282 ( 4.8A)
None
PEB  C 282 ( 3.9A)
None
 1.23A 4x1iB-1xg0C:
undetectable		 4x1iB-1xg0C:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yc6 COAT PROTEIN

(Brome mosaic
virus) 		no annotation 5 ALA A 158
LEU A 156
ASN A  67
MET A  69
ALA A 166
 None
 1.08A 4x1iB-1yc6A:
undetectable		 4x1iB-1yc6A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yyh NOTCH 1, ANKYRIN
DOMAIN

(Homo sapiens) 		PF12796
(Ank_2) 		5 LEU A 128
ALA A 148
ASN A 145
VAL A  98
ALA A 131
 None
 1.12A 4x1iB-1yyhA:
undetectable		 4x1iB-1yyhA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA

(Mycobacterium
tuberculosis) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 LEU A 105
ALA A 109
LEU A 150
THR A 158
VAL A 133
 None
 1.00A 4x1iB-1zj9A:
undetectable		 4x1iB-1zj9A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayz SENSOR KINASE
PROTEIN RCSC

(Escherichia
coli) 		PF00072
(Response_reg) 		5 LYS A 866
LEU A 864
VAL A 830
LYS A 852
ALA A 854
 None
 1.19A 4x1iB-2ayzA:
4.1		 4x1iB-2ayzA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS

(Mus musculus) 		PF01494
(FAD_binding_3) 		5 LEU A  97
ALA A  92
VAL A 173
LYS A 166
ALA A 168
 None
 1.19A 4x1iB-2braA:
undetectable		 4x1iB-2braA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc0 PROBABLE AMIDASE

(Thermus
thermophilus) 		PF01425
(Amidase) 		5 LEU A  21
ALA A  45
LEU A  40
ALA A  28
ALA A  24
 None
 1.10A 4x1iB-2dc0A:
undetectable		 4x1iB-2dc0A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ALA A 436
LEU A   7
THR A  53
ALA A  57
VAL A  61
 None
 1.26A 4x1iB-2dpnA:
undetectable		 4x1iB-2dpnA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpw HYPOTHETICAL PROTEIN
TTHA0179

(Thermus
thermophilus) 		PF12804
(NTP_transf_3) 		5 LEU A  97
ALA A  41
ALA A   5
VAL A   7
ALA A  90
 None
 1.08A 4x1iB-2dpwA:
undetectable		 4x1iB-2dpwA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Aquifex
aeolicus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A  97
ALA A  58
ALA A 104
VAL A 102
ALA A  99
 None
 1.19A 4x1iB-2ebdA:
undetectable		 4x1iB-2ebdA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 LEU A 271
ALA A 267
ALA A  94
VAL A  96
ALA A 316
 None
 1.07A 4x1iB-2elcA:
undetectable		 4x1iB-2elcA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 208
ALA A 246
LEU A 248
ALA A 300
ALA A 209
 None
 1.23A 4x1iB-2f9qA:
undetectable		 4x1iB-2f9qA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6e D-ARABINOSE
1-DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 258
ALA A 226
ASN A 177
VAL A 173
ALA A 239
 None
 1.18A 4x1iB-2h6eA:
3.6		 4x1iB-2h6eA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i44 SERINE-THREONINE
PHOSPHATASE 2C

(Toxoplasma
gondii) 		PF00481
(PP2C) 		5 LEU A  86
ALA A 119
LEU A 116
ALA A 153
VAL A  54
 None
 1.26A 4x1iB-2i44A:
undetectable		 4x1iB-2i44A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A 367
ALA A 353
ALA A 342
VAL A 344
ALA A 361
 None
 1.08A 4x1iB-2oi6A:
undetectable		 4x1iB-2oi6A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qs7 UNCHARACTERIZED
PROTEIN

(Sulfolobus
solfataricus) 		PF13686
(DrsE_2) 		5 LYS A 100
LEU A  40
ASN A  39
THR A 140
ALA A  31
 None
None
None
EPE  A 145 (-4.4A)
None
 1.15A 4x1iB-2qs7A:
undetectable		 4x1iB-2qs7A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		5 LEU A 110
LYS A 241
LEU A 240
THR A 229
ALA A 238
 None
 1.26A 4x1iB-2ww2A:
undetectable		 4x1iB-2ww2A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5r HYPOTHETICAL PROTEIN
ORF126

(Pyrobaculum
spherical virus) 		no annotation 5 LEU A  61
ALA A  65
ASN A 100
ALA A  97
VAL A  41
 None
 1.01A 4x1iB-2x5rA:
undetectable		 4x1iB-2x5rA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a24 ALPHA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		5 LEU A 185
ALA A 222
LEU A 220
VAL A 197
ALA A 152
 None
 1.09A 4x1iB-3a24A:
undetectable		 4x1iB-3a24A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8t FUMARATE LYASE

(Chelativorans
sp. BNC1) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 LEU A 150
ALA A 177
LEU A 261
ALA A 352
ALA A 146
 None
 1.26A 4x1iB-3c8tA:
undetectable		 4x1iB-3c8tA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnj CHOLESTEROL OXIDASE

(Streptomyces
sp. SA-COO) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 LEU A 375
ALA A 327
THR A 380
ALA A 360
ALA A 363
 None
 1.26A 4x1iB-3cnjA:
undetectable		 4x1iB-3cnjA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpr DIHYDRODIPICOLINATE
SYNTHETASE

(Corynebacterium
glutamicum) 		PF00701
(DHDPS) 		5 ALA A 110
LYS A  76
THR A  26
ALA A  57
VAL A  92
 None
 1.18A 4x1iB-3cprA:
undetectable		 4x1iB-3cprA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du1 ALL3740 PROTEIN

(Nostoc sp. PCC
7120) 		PF00805
(Pentapeptide) 		5 LEU X 157
ALA X 155
LEU X 127
VAL X 140
ALA X 160
 None
 1.25A 4x1iB-3du1X:
undetectable		 4x1iB-3du1X:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 2/3 COMPLEX
SUBUNIT 1

(Schizosaccharomyces
pombe) 		PF00400
(WD40) 		5 LEU C 152
ALA C 163
LEU C 145
VAL C 126
ALA C 116
 None
 1.18A 4x1iB-3dwlC:
undetectable		 4x1iB-3dwlC:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 CYH A 694
LEU A 662
ALA A 665
VAL A 746
ALA A 747
 None
 1.12A 4x1iB-3dy5A:
undetectable		 4x1iB-3dy5A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3el6 ERYTHROMYCIN
DEHYDRATASE

(Saccharopolyspora
erythraea) 		PF14765
(PS-DH) 		5 LEU A 175
LEU A 212
ALA A 246
VAL A 244
ALA A 187
 None
 1.08A 4x1iB-3el6A:
undetectable		 4x1iB-3el6A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgb UNCHARACTERIZED
PROTEIN Q89ZH8_BACTN

(Bacteroides
thetaiotaomicron) 		PF10282
(Lactonase) 		5 LEU A  51
ALA A  69
LEU A 113
ALA A 101
ALA A  88
 None
 1.13A 4x1iB-3fgbA:
undetectable		 4x1iB-3fgbA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3frn FLAGELLAR PROTEIN
FLGA

(Thermotoga
maritima) 		PF13144
(ChapFlgA) 		5 ALA A 104
LEU A 154
ASN A 135
VAL A 129
LYS A 131
 None
 1.27A 4x1iB-3frnA:
undetectable		 4x1iB-3frnA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fww BIFUNCTIONAL PROTEIN
GLMU

(Yersinia pestis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A 332
ALA A 336
LEU A 355
THR A 382
ALA A 330
 None
 1.27A 4x1iB-3fwwA:
undetectable		 4x1iB-3fwwA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		5 LYS A  50
LEU A  48
ASN A  51
ALA A  26
ALA A  22
 None
 1.22A 4x1iB-3fydA:
undetectable		 4x1iB-3fydA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		5 ALA A 681
LEU A 678
ALA A 647
VAL A 644
ALA A 629
 None
 1.27A 4x1iB-3g06A:
undetectable		 4x1iB-3g06A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8a RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G

(Thermus
thermophilus) 		PF02527
(GidB) 		5 LEU A 166
LEU A 171
ALA A 180
VAL A 224
ALA A 182
 None
 1.23A 4x1iB-3g8aA:
undetectable		 4x1iB-3g8aA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdj PROBABLE ORNITHINE
CYCLODEAMINASE

(Bordetella
pertussis) 		PF02423
(OCD_Mu_crystall) 		5 LEU A 219
ALA A 208
LYS A 282
ALA A 227
ALA A 223
 CL  A 314 (-4.3A)
CL  A 314 ( 4.5A)
GOL  A 316 (-2.3A)
None
None
 1.24A 4x1iB-3hdjA:
undetectable		 4x1iB-3hdjA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lud PROTEIN ARGONAUTE-2

(Homo sapiens) 		PF02171
(Piwi)
PF16487
(ArgoMid) 		5 LYS A 509
LEU A 508
MET A 504
ALA A 454
VAL A 519
 None
 1.22A 4x1iB-3ludA:
undetectable		 4x1iB-3ludA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7o LYMPHOCYTE ANTIGEN
86

(Mus musculus) 		PF02221
(E1_DerP2_DerF2) 		5 LEU A  53
LEU A 142
ALA A 157
VAL A  40
ALA A  32
 None
L9R  A 301 (-4.0A)
None
None
None
 1.17A 4x1iB-3m7oA:
undetectable		 4x1iB-3m7oA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca PROTEIN DOM34

(Schizosaccharomyces
pombe) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		5 LEU B 243
LEU B 257
ALA B 139
VAL B 141
ALA B 208
 None
 0.99A 4x1iB-3mcaB:
undetectable		 4x1iB-3mcaB:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl2 SUGAR KINASE,
RIBOKINASE FAMILY

(Corynebacterium
glutamicum) 		PF00294
(PfkB) 		5 CYH A 205
LEU A 171
ALA A 208
ALA A 229
VAL A 231
 None
 1.00A 4x1iB-3pl2A:
5.3		 4x1iB-3pl2A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psh PROTEIN HI_1472

(Haemophilus
influenzae) 		PF01497
(Peripla_BP_2) 		5 LEU A 284
ALA A 283
THR A 216
ALA A 210
VAL A 269
 None
 1.20A 4x1iB-3pshA:
undetectable		 4x1iB-3pshA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyj ALR0039 PROTEIN

(Nostoc sp. PCC
7120) 		PF00561
(Abhydrolase_1) 		5 LEU A 237
ASN A 286
THR A 289
VAL A 101
ALA A 125
 None
 1.11A 4x1iB-3qyjA:
undetectable		 4x1iB-3qyjA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF00982
(Glyco_transf_20) 		5 ALA A 141
LYS A 144
LEU A 143
VAL A 156
ALA A   9
 None
 1.27A 4x1iB-3t5tA:
5.1		 4x1iB-3t5tA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6q LYMPHOCYTE ANTIGEN
86

(Mus musculus) 		PF02221
(E1_DerP2_DerF2) 		5 LEU C  53
LEU C 142
ALA C 157
VAL C  40
ALA C  32
 None
 1.20A 4x1iB-3t6qC:
undetectable		 4x1iB-3t6qC:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twd BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep) 		5 LEU A 367
ALA A 353
ALA A 342
VAL A 344
ALA A 361
 None
 1.11A 4x1iB-3twdA:
undetectable		 4x1iB-3twdA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2q ATP SYNTHASE SUBUNIT
BETA, MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 LYS D  45
LEU D  46
THR D  61
ALA D  63
ALA D 228
 None
 1.12A 4x1iB-4b2qD:
2.6		 4x1iB-4b2qD:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg5 BBA65

(Borreliella
burgdorferi) 		PF05714
(Borrelia_lipo_1) 		5 LEU A 224
ALA A 136
LEU A 140
ASN A 143
MET A 144
 None
 1.24A 4x1iB-4bg5A:
undetectable		 4x1iB-4bg5A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxy PLM1

(Streptomyces
sp. HK803) 		PF08659
(KR) 		5 LEU A  71
ALA A 114
THR A  86
ALA A  61
ALA A  70
 None
 1.27A 4x1iB-4hxyA:
3.4		 4x1iB-4hxyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifr 2-AMINO-3-CARBOXYMUC
ONATE 6-SEMIALDEHYDE
DECARBOXYLASE

(Pseudomonas
fluorescens) 		PF04909
(Amidohydro_2) 		5 LEU A 126
ALA A 162
ALA A 133
LYS A 131
ALA A 129
 None
 1.22A 4x1iB-4ifrA:
undetectable		 4x1iB-4ifrA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m38 PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Trypanosoma
brucei) 		PF06325
(PrmA) 		5 CYH A 215
LEU A 218
ALA A 299
LEU A 301
VAL A 257
 None
 1.09A 4x1iB-4m38A:
undetectable		 4x1iB-4m38A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkv RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Pisum sativum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 LEU A 280
LEU A 289
ASN A 287
ALA A 257
ALA A 242
 None
 1.24A 4x1iB-4mkvA:
undetectable		 4x1iB-4mkvA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0g PROTEIN PHOSPHATASE
2C 37

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		6 CYH A 321
LEU A 346
LYS A 104
ASN A 360
ALA A 366
ALA A 342
 None
 1.28A 4x1iB-4n0gA:
undetectable		 4x1iB-4n0gA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdy AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Alicyclobacillus
acidocaldarius) 		PF01636
(APH) 		5 LEU A 254
LYS A 152
ALA A 297
VAL A 295
ALA A 257
 None
 1.23A 4x1iB-4pdyA:
undetectable		 4x1iB-4pdyA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qax 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Staphylococcus
aureus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		5 LEU A 111
ALA A 136
LEU A  97
ALA A 287
ALA A 250
 None
 1.21A 4x1iB-4qaxA:
3.1		 4x1iB-4qaxA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qh6 CRUZIPAIN

(Trypanosoma
cruzi) 		PF00112
(Peptidase_C1) 		5 LEU A 118
LEU A 129
ASN A 132
VAL A 137
ALA A 209
 None
 1.23A 4x1iB-4qh6A:
undetectable		 4x1iB-4qh6A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6y PUTATIVE
2-AMINOETHYLPHOSPHON
ATE-BINDING
PERIPLASMIC PROTEIN

(Salmonella
enterica) 		PF13343
(SBP_bac_6) 		5 LEU A  98
ALA A  92
LEU A  70
THR A  26
ALA A  99
 None
 1.26A 4x1iB-4r6yA:
undetectable		 4x1iB-4r6yA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rye D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Mycobacterium
tuberculosis) 		PF00768
(Peptidase_S11) 		5 LEU A 291
THR A  44
ALA A 255
VAL A 253
ALA A  48
 None
 1.16A 4x1iB-4ryeA:
undetectable		 4x1iB-4ryeA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18)
PF06483
(ChiC) 		5 LYS A 303
LEU A 301
THR A 248
VAL A 252
ALA A 191
 None
 1.10A 4x1iB-4txgA:
2.8		 4x1iB-4txgA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txk PROTEIN-METHIONINE
SULFOXIDE OXIDASE
MICAL1

(Mus musculus) 		PF00307
(CH)
PF01494
(FAD_binding_3) 		5 LEU A  97
ALA A  92
VAL A 173
LYS A 166
ALA A 168
 None
 1.14A 4x1iB-4txkA:
2.9		 4x1iB-4txkA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3t PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase) 		5 LEU A 386
ALA A 434
LEU A 438
ALA A 318
VAL A 316
 None
 1.15A 4x1iB-4u3tA:
undetectable		 4x1iB-4u3tA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z1p CELL WALL SURFACE
ANCHOR PROTEIN

(Streptococcus
agalactiae) 		PF16364
(Antigen_C) 		5 LEU A  59
ALA A  58
LEU A 170
ASN A 168
ALA A  22
 None
 1.21A 4x1iB-4z1pA:
undetectable		 4x1iB-4z1pA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE

(Bacillus
subtilis) 		PF00698
(Acyl_transf_1) 		5 LEU A 139
LYS A 132
LEU A 130
VAL A 173
ALA A 170
 None
 1.24A 4x1iB-5dz7A:
undetectable		 4x1iB-5dz7A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4x SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS PROTEIN 3

(Rattus
norvegicus) 		PF12796
(Ank_2)
PF16511
(FERM_f0) 		5 ALA A 174
LEU A 135
ASN A 171
VAL A 123
ALA A 156
 None
EDO  A1355 ( 4.4A)
None
None
None
 1.25A 4x1iB-5g4xA:
undetectable		 4x1iB-5g4xA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5x PUTATIVE
OXIDOREDUCTASE

(Streptomyces
coelicolor) 		PF13561
(adh_short_C2) 		5 LEU A  63
ALA A  36
ALA A  56
LYS A  58
ALA A  60
 None
 1.20A 4x1iB-5h5xA:
6.7		 4x1iB-5h5xA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h6o PORPHOBILINOGEN
DEAMINASE

(Vibrio cholerae) 		no annotation 5 LEU A 244
ASN A 241
MET A 240
ALA A 267
VAL A 278
 None
 1.14A 4x1iB-5h6oA:
undetectable		 4x1iB-5h6oA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Mycobacterium
tuberculosis) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		5 LEU A  73
ASN A 371
THR A 378
ALA A 382
VAL A 345
 None
 1.22A 4x1iB-5i67A:
undetectable		 4x1iB-5i67A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5isv RIBOSOMAL-PROTEIN-AL
ANINE
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00583
(Acetyltransf_1) 		5 ALA A  83
LEU A  85
THR A  57
ALA A  55
ALA A  53
 None
 1.16A 4x1iB-5isvA:
undetectable		 4x1iB-5isvA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5isv RIBOSOMAL-PROTEIN-AL
ANINE
ACETYLTRANSFERASE

(Escherichia
coli) 		PF00583
(Acetyltransf_1) 		5 ALA A  83
LEU A  85
THR A  57
VAL A  71
ALA A  53
 None
 1.02A 4x1iB-5isvA:
undetectable		 4x1iB-5isvA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jlc LANOSTEROL 14-ALPHA
DEMETHYLASE

([Candida]
glabrata) 		PF00067
(p450) 		5 ALA A 332
LEU A 329
THR A 517
ALA A 520
VAL A 195
 None
 1.23A 4x1iB-5jlcA:
undetectable		 4x1iB-5jlcA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jse PHIAB6 TAILSPIKE

(unidentified
phage) 		PF12708
(Pectate_lyase_3) 		5 LYS A 133
LEU A 132
ASN A 134
VAL A  92
ALA A  97
 None
 1.15A 4x1iB-5jseA:
undetectable		 4x1iB-5jseA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksh PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LEU A 386
ALA A 434
LEU A 438
ALA A 318
VAL A 316
 None
 1.11A 4x1iB-5kshA:
undetectable		 4x1iB-5kshA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 2

(Sus scrofa) 		no annotation 5 CYH A 773
LEU A 786
ALA A 850
VAL A 848
ALA A 785
 None
 1.22A 4x1iB-5mpmA:
undetectable		 4x1iB-5mpmA:
10.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 ALA B 250
LYS B 254
ASN B 258
MET B 259
THR B 314
 None
 0.67A 4x1iB-5n5nB:
54.3		 4x1iB-5n5nB:
97.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5n5n TUBULIN BETA CHAIN

(Homo sapiens) 		no annotation 5 MET B 259
THR B 314
ALA B 316
VAL B 318
ALA B 354
 None
 0.78A 4x1iB-5n5nB:
54.3		 4x1iB-5n5nB:
97.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzp D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Homo sapiens) 		no annotation 5 CYH B 254
LEU B 249
THR B 263
VAL B 231
ALA B 257
 None
 1.19A 4x1iB-5nzpB:
2.3		 4x1iB-5nzpB:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE

(Methanocaldococcus
jannaschii) 		no annotation 5 LYS A 340
LEU A 342
ASN A 341
THR A 269
VAL A 286
 None
 1.19A 4x1iB-5od2A:
4.4		 4x1iB-5od2A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcb PELA

(Pseudomonas
aeruginosa) 		PF03537
(Glyco_hydro_114) 		5 LEU A 205
LEU A 162
ASN A 199
VAL A 211
ALA A 212
 None
 1.24A 4x1iB-5tcbA:
undetectable		 4x1iB-5tcbA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8x LIPID-A-DISACCHARIDE
SYNTHASE

(Escherichia
coli) 		no annotation 5 CYH A 282
LEU A 273
ALA A 278
ALA A 264
ALA A 271
 None
None
UDP  A 401 ( 3.4A)
None
None
 1.14A 4x1iB-5w8xA:
4.7		 4x1iB-5w8xA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 5 CYH A 622
ALA A 625
LEU A 627
VAL A 535
ALA A 534
 None
 1.15A 4x1iB-5wdxA:
undetectable		 4x1iB-5wdxA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN
S1E

(Leishmania
donovani) 		no annotation 5 LYS A 164
LEU A 166
THR A 121
ALA A 143
VAL A 141
 U  11195 ( 3.7A)
None
None
None
None
 1.23A 4x1iB-6az1A:
undetectable		 4x1iB-6az1A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az1 RIBOSOMAL PROTEIN
S1E

(Leishmania
donovani) 		no annotation 5 LYS A 164
LEU A 166
THR A 145
ALA A 143
VAL A 141
 U  11195 ( 3.7A)
None
None
None
None
 1.27A 4x1iB-6az1A:
undetectable		 4x1iB-6az1A:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5v TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5

(Oryctolagus
cuniculus) 		no annotation 5 LEU A 132
ALA A 135
THR A  81
ALA A 120
ALA A 124
 None
 1.11A 4x1iB-6b5vA:
undetectable		 4x1iB-6b5vA:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b74 COAGULATION FACTOR
XII

(Homo sapiens) 		no annotation 5 LEU B  68
ALA B  31
THR B 242
ALA B  48
ALA B 112
 None
 1.21A 4x1iB-6b74B:
undetectable		 4x1iB-6b74B:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9e CYSTEINE DESULFURASE

(Legionella
pneumophila) 		no annotation 5 LYS A 168
LEU A 169
ASN A 170
ALA A 203
VAL A 205
 None
 1.17A 4x1iB-6c9eA:
undetectable		 4x1iB-6c9eA:
12.38