SIMILAR PATTERNS OF AMINO ACIDS FOR 4X1G_A_3WFA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ax8 OBESITY PROTEIN

(Homo sapiens) 		PF02024
(Leptin) 		5 LEU A 129
SER A 127
LEU A  65
MET A  68
ILE A  76
 None
 1.01A 4x1gA-1ax8A:
undetectable		 4x1gA-1ax8A:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8u PROTEIN (MALATE
DEHYDROGENASE)

(Aquaspirillum
arcticum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ASP A  29
LEU A  88
ARG A  24
LEU A  22
ILE A  25
 None
 1.07A 4x1gA-1b8uA:
undetectable		 4x1gA-1b8uA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgs DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		5 ASP A 371
LEU A 322
LEU A 356
LEU A 365
ILE A 367
 None
 1.00A 4x1gA-1dgsA:
0.0		 4x1gA-1dgsA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eom ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F3

(Elizabethkingia
meningoseptica) 		PF00704
(Glyco_hydro_18) 		5 ASP A  69
LEU A  68
LEU A  38
PHE A 173
ILE A  72
 None
 0.94A 4x1gA-1eomA:
0.0		 4x1gA-1eomA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8v MATURE CAPSID
PROTEIN BETA

(Pariacoto virus) 		PF01829
(Peptidase_A6) 		5 LEU A 219
LEU A 275
PHE A 159
LEU A 190
ILE A 216
 None
 1.13A 4x1gA-1f8vA:
0.0		 4x1gA-1f8vA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyd ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE A

(Cellvibrio
japonicus) 		PF04616
(Glyco_hydro_43) 		5 LEU B 338
SER B 340
LEU B 289
LEU B 303
ILE B 280
 None
 1.13A 4x1gA-1gydB:
0.0		 4x1gA-1gydB:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iuh 2'-5' RNA LIGASE

(Thermus
thermophilus) 		PF02834
(LigT_PEase) 		5 LEU A  17
LEU A  74
PHE A  70
LEU A  40
ILE A 131
 None
 1.08A 4x1gA-1iuhA:
0.0		 4x1gA-1iuhA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrv LEUCINE-RICH REPEAT
VARIANT

(Azotobacter
vinelandii) 		PF01816
(LRV)
PF05484
(LRV_FeS) 		5 LEU A 106
LEU A  98
ARG A  91
LEU A  82
ILE A  83
 None
 1.13A 4x1gA-1lrvA:
0.0		 4x1gA-1lrvA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obb ALPHA-GLUCOSIDASE

(Thermotoga
maritima) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		5 LEU A 242
SER A 243
LEU A 221
LEU A 207
ILE A 183
 None
 1.13A 4x1gA-1obbA:
0.0		 4x1gA-1obbA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		5 ASP A 351
LEU A 352
LEU A 316
LEU A 334
ILE A 349
 PY1  A 700 (-2.7A)
None
None
None
None
 1.12A 4x1gA-1py5A:
0.0		 4x1gA-1py5A:
22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1skx ORPHAN NUCLEAR
RECEPTOR PXR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 240
SER A 247
PHE A 251
ARG A 410
LEU A 411
ILE A 414
MET A 425
 RFP  A   1 (-3.5A)
RFP  A   1 (-3.1A)
RFP  A   1 (-4.7A)
RFP  A   1 ( 4.2A)
RFP  A   1 ( 4.7A)
RFP  A   1 ( 4.2A)
None
 0.73A 4x1gA-1skxA:
37.7		 4x1gA-1skxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1skx ORPHAN NUCLEAR
RECEPTOR PXR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 MET A 243
PHE A 251
ARG A 410
LEU A 411
MET A 425
 RFP  A   1 (-3.5A)
RFP  A   1 (-4.7A)
RFP  A   1 ( 4.2A)
RFP  A   1 ( 4.7A)
None
 1.01A 4x1gA-1skxA:
37.7		 4x1gA-1skxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE

(Geotrichum sp.
M128) 		PF15899
(BNR_6) 		5 LEU A  71
SER A 772
PHE A  55
LEU A  81
ILE A  69
 None
 1.12A 4x1gA-1sqjA:
undetectable		 4x1gA-1sqjA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf2 CORE PROTEIN P3

(Rice dwarf
virus) 		PF09231
(RDV-p3) 		5 ASP A 410
LEU A 391
PHE A 359
LEU A 403
ILE A 411
 None
 1.01A 4x1gA-1uf2A:
undetectable		 4x1gA-1uf2A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v60 RIKEN CDNA
1810037G04

(Mus musculus) 		PF01722
(BolA) 		5 LEU A 104
PHE A  77
ARG A  37
LEU A  40
ILE A  36
 None
 1.06A 4x1gA-1v60A:
undetectable		 4x1gA-1v60A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		5 ASP A 374
LEU A 325
LEU A 359
LEU A 368
ILE A 370
 None
 1.04A 4x1gA-1v9pA:
undetectable		 4x1gA-1v9pA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgw 4-DIPHOSPHOCYTIDYL-2
C-METHYL-D-ERYTHRITO
L SYNTHASE

(Neisseria
gonorrhoeae) 		PF01128
(IspD) 		5 LEU A  93
LEU A   8
HIS A 176
LEU A 175
ILE A 105
 None
 0.95A 4x1gA-1vgwA:
undetectable		 4x1gA-1vgwA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2d INOSITOL-TRISPHOSPHA
TE 3-KINASE A

(Homo sapiens) 		PF03770
(IPK) 		6 LEU A 377
LEU A 400
MET A 265
ARG A 381
LEU A 384
ILE A 380
 None
 1.05A 4x1gA-1w2dA:
undetectable		 4x1gA-1w2dA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a98 INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE C

(Homo sapiens) 		PF03770
(IPK) 		5 LEU A 599
LEU A 622
MET A 487
ARG A 603
LEU A 606
 None
 1.13A 4x1gA-2a98A:
undetectable		 4x1gA-2a98A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aeh FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M) 		5 LEU A 220
LEU A 203
ARG A 221
LEU A 188
ILE A 224
 None
 1.04A 4x1gA-2aehA:
undetectable		 4x1gA-2aehA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqx PREDICTED: INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE B

(Mus musculus) 		PF03770
(IPK) 		5 LEU A 854
LEU A 877
MET A 742
LEU A 861
ILE A 857
 None
 1.08A 4x1gA-2aqxA:
undetectable		 4x1gA-2aqxA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbk METHYLAMINE
DEHYDROGENASE (HEAVY
SUBUNIT)

(Paracoccus
denitrificans) 		PF06433
(Me-amine-dh_H) 		5 ASP H 240
LEU H 241
SER H 243
LEU H 188
ILE H 239
 None
 1.03A 4x1gA-2bbkH:
undetectable		 4x1gA-2bbkH:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cic DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDE HYDROLASE

(Campylobacter
jejuni) 		PF08761
(dUTPase_2) 		5 ASP A 132
LEU A 157
LEU A  50
LEU A 130
ILE A 133
 None
 1.06A 4x1gA-2cicA:
undetectable		 4x1gA-2cicA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqr PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Helicobacter
pylori) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		5 LEU A  72
SER A  74
LEU A  47
LEU A  20
ILE A 109
 None
 1.04A 4x1gA-2hqrA:
undetectable		 4x1gA-2hqrA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		5 LEU A 220
LEU A 203
ARG A 221
LEU A 188
ILE A 224
 None
 1.05A 4x1gA-2j0jA:
undetectable		 4x1gA-2j0jA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k4w SUPEROXIDE DISMUTASE
[CU-ZN]

(Salmonella
enterica) 		PF00080
(Sod_Cu) 		5 LEU A  94
LEU A 114
HIS A  90
LEU A  74
ILE A  49
 None
None
ZN  A 156 (-3.2A)
None
None
 1.03A 4x1gA-2k4wA:
undetectable		 4x1gA-2k4wA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kjg ARCHAEAL PROTEIN
SSO6904

(Sulfolobus
solfataricus) 		no annotation 5 ASP A  29
LEU A  28
LEU A  70
LEU A  35
ILE A  31
 None
 1.07A 4x1gA-2kjgA:
undetectable		 4x1gA-2kjgA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mn4 COMPUTATIONAL
DESIGNED PROTEIN
BASED ON STRUCTURE
TEMPLATE 1CY5

(synthetic
construct) 		PF00619
(CARD) 		5 ASP A  21
LEU A  20
LEU A  56
LEU A  26
ILE A  25
 None
 1.08A 4x1gA-2mn4A:
undetectable		 4x1gA-2mn4A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq3 ITCHY HOMOLOG E3
UBIQUITIN PROTEIN
LIGASE

(Homo sapiens) 		PF00168
(C2) 		5 LEU A 106
SER A 108
LEU A 142
LEU A  79
ILE A 102
 None
 1.09A 4x1gA-2nq3A:
undetectable		 4x1gA-2nq3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vef DIHYDROPTEROATE
SYNTHASE

(Streptococcus
pneumoniae) 		PF00809
(Pterin_bind) 		5 LEU A 216
LEU A 208
PHE A 160
LEU A 176
ILE A 173
 None
 1.12A 4x1gA-2vefA:
undetectable		 4x1gA-2vefA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vkt CTP SYNTHASE 2

(Homo sapiens) 		PF00117
(GATase) 		5 ASP A 365
LEU A 543
HIS A 330
LEU A 332
ILE A 301
 None
 1.09A 4x1gA-2vktA:
undetectable		 4x1gA-2vktA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrd HEMAGGLUTININ

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 LEU A 176
LEU A 105
SER A  60
LEU A  66
ILE A 178
 None
 1.01A 4x1gA-2wrdA:
undetectable		 4x1gA-2wrdA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 ASP A  34
LEU A  37
LEU A  81
LEU A  32
ILE A  33
 None
 1.12A 4x1gA-2wyhA:
undetectable		 4x1gA-2wyhA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x24 ACETYL-COA
CARBOXYLASE

(Bos taurus) 		PF01039
(Carboxyl_trans) 		5 SER A 254
LEU A 335
MET A 338
ARG A 149
ILE A 113
 None
 1.02A 4x1gA-2x24A:
undetectable		 4x1gA-2x24A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfs ORF12

(Streptomyces
clavuligerus) 		PF13354
(Beta-lactamase2) 		5 LEU A 432
SER A 434
LEU A 399
SER A 163
ILE A 424
 None
 0.99A 4x1gA-2xfsA:
undetectable		 4x1gA-2xfsA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwu IMPORTIN13

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1) 		5 LEU B 610
SER B 612
LEU B 651
LEU B 601
ILE B 606
 None
 1.08A 4x1gA-2xwuB:
undetectable		 4x1gA-2xwuB:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjp PUTATIVE ABC
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, AMINO ACID

(Neisseria
gonorrhoeae) 		PF00497
(SBP_bac_3) 		5 ASP A  80
LEU A  81
ARG A 259
LEU A 260
ILE A  77
 None
 1.08A 4x1gA-2yjpA:
undetectable		 4x1gA-2yjpA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjq CEL44C

(Paenibacillus
polymyxa) 		PF12891
(Glyco_hydro_44) 		5 LEU A 341
SER A 344
ARG A 340
LEU A 335
ILE A 337
 None
 1.04A 4x1gA-2yjqA:
undetectable		 4x1gA-2yjqA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio) 		PF00514
(Arm) 		5 LEU A 579
LEU A 526
ARG A 514
LEU A 512
ILE A 513
 None
 1.10A 4x1gA-2z6gA:
undetectable		 4x1gA-2z6gA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc8 N-ACYLAMINO ACID
RACEMASE

(Thermus
thermophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  86
LEU A 103
ARG A  78
LEU A  76
MET A 366
 None
 1.05A 4x1gA-2zc8A:
undetectable		 4x1gA-2zc8A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apm PROTEIN-ARGININE
DEIMINASE TYPE-4

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		5 LEU A 199
LEU A 185
MET A 247
HIS A 236
ILE A 269
 None
 1.12A 4x1gA-3apmA:
undetectable		 4x1gA-3apmA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME

(Schistosoma
japonicum) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 SER A 107
LEU A 126
MET A 129
ARG A 103
LEU A 159
 None
 1.11A 4x1gA-3cruA:
undetectable		 4x1gA-3cruA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doo SHIKIMATE
DEHYDROGENASE

(Staphylococcus
epidermidis) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		5 LEU A 173
PHE A 154
HIS A 168
LEU A 166
ILE A 195
 None
 1.04A 4x1gA-3dooA:
undetectable		 4x1gA-3dooA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fze PROTEIN STE5

(Saccharomyces
cerevisiae) 		PF12194
(Ste5_C) 		5 LEU A 621
LEU A 627
SER A 633
LEU A 614
ILE A 616
 None
 1.13A 4x1gA-3fzeA:
undetectable		 4x1gA-3fzeA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5i PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		5 ASP A  14
LEU A 239
LEU A 303
SER A  25
ILE A  17
 DNB  A 502 (-2.9A)
None
None
None
None
 1.06A 4x1gA-3g5iA:
undetectable		 4x1gA-3g5iA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ivp PUTATIVE
TRANSPOSON-RELATED
DNA-BINDING PROTEIN

(Clostridioides
difficile) 		PF01381
(HTH_3) 		5 ASP A  59
LEU A  60
SER A  62
LEU A  42
ILE A  37
 None
 1.03A 4x1gA-3ivpA:
undetectable		 4x1gA-3ivpA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN ES26
40S RIBOSOMAL
PROTEIN US11

(Plasmodium
falciparum) 		PF00411
(Ribosomal_S11)
PF01283
(Ribosomal_S26e) 		6 ASP P 131
LEU P  97
LEU P 116
SER 3  57
LEU 3  64
ILE 3  44
 None
 1.37A 4x1gA-3j7aP:
undetectable		 4x1gA-3j7aP:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4r UNCHARACTERIZED
PROTEIN

(Thermoplasma
acidophilum) 		PF00596
(Aldolase_II) 		5 ASP A 178
LEU A 187
ARG A 200
ILE A 204
MET A   1
 None
 1.11A 4x1gA-3m4rA:
undetectable		 4x1gA-3m4rA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3w RIBONUCLEASE III

(Campylobacter
jejuni) 		PF14622
(Ribonucleas_3_3) 		5 LEU A  21
LEU A  11
SER A  86
LEU A 115
ILE A 118
 None
 1.08A 4x1gA-3n3wA:
undetectable		 4x1gA-3n3wA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3w RIBONUCLEASE III

(Campylobacter
jejuni) 		PF14622
(Ribonucleas_3_3) 		5 LEU A  25
LEU A   7
SER A  86
LEU A 115
ILE A 118
 None
 0.99A 4x1gA-3n3wA:
undetectable		 4x1gA-3n3wA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 LEU A 118
SER A 116
LEU A 250
MET A 253
ILE A 136
 None
 1.14A 4x1gA-3nieA:
undetectable		 4x1gA-3nieA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2p CELL DIVISION
CONTROL PROTEIN 53

(Saccharomyces
cerevisiae) 		PF10557
(Cullin_Nedd8) 		5 LEU E 802
LEU E 770
SER E 778
PHE E 782
ILE E 793
 None
None
None
None
GOL  E3968 (-3.4A)
 1.09A 4x1gA-3o2pE:
undetectable		 4x1gA-3o2pE:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2r RIBONUCLEASE III

(Campylobacter
jejuni) 		PF14622
(Ribonucleas_3_3) 		5 LEU B  21
LEU B  11
SER B  86
LEU B 115
ILE B 118
 None
 1.05A 4x1gA-3o2rB:
undetectable		 4x1gA-3o2rB:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2r RIBONUCLEASE III

(Campylobacter
jejuni) 		PF14622
(Ribonucleas_3_3) 		5 LEU B  25
LEU B   7
SER B  86
LEU B 115
ILE B 118
 None
 1.03A 4x1gA-3o2rB:
undetectable		 4x1gA-3o2rB:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogk CORONATINE-INSENSITI
VE PROTEIN 1

(Arabidopsis
thaliana) 		no annotation 5 LEU B 132
LEU B 143
SER B 174
LEU B 156
ILE B 159
 None
 1.13A 4x1gA-3ogkB:
undetectable		 4x1gA-3ogkB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3piw TYPE I INTERFERON 2

(Danio rerio) 		PF00143
(Interferon) 		5 ASP A 155
LEU A  45
PHE A  71
LEU A 153
ILE A 156
 None
 1.05A 4x1gA-3piwA:
undetectable		 4x1gA-3piwA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyf CRISPR-ASSOCIATED
PROTEIN

(Sulfolobus
solfataricus) 		PF09651
(Cas_APE2256) 		5 LEU A  37
LEU A  31
SER A  16
LEU A 104
ILE A  47
 None
 1.12A 4x1gA-3qyfA:
undetectable		 4x1gA-3qyfA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u88 LENS
EPITHELIUM-DERIVED
GROWTH FACTOR

(Homo sapiens) 		PF11467
(LEDGF) 		5 LEU C 400
LEU C 377
SER C 409
LEU C 363
ILE C 359
 None
 1.01A 4x1gA-3u88C:
undetectable		 4x1gA-3u88C:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF02569
(Pantoate_ligase) 		5 ASP A 258
LEU A 260
LEU A 217
ARG A 242
ILE A 254
 None
 1.00A 4x1gA-3uk2A:
undetectable		 4x1gA-3uk2A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v64 LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 4

(Rattus
norvegicus) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		5 LEU C 525
LEU C 516
ARG C 494
LEU C 493
ILE C 492
 None
 1.05A 4x1gA-3v64C:
undetectable		 4x1gA-3v64C:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v65 LOW-DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 4

(Rattus
norvegicus) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		5 LEU B 525
LEU B 516
ARG B 494
LEU B 493
ILE B 492
 None
 1.01A 4x1gA-3v65B:
undetectable		 4x1gA-3v65B:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6e HYDROXYINDOLE
O-METHYLTRANSFERASE

(Homo sapiens) 		PF00891
(Methyltransf_2)
PF16864
(Dimerisation2) 		5 LEU A 242
LEU A 186
HIS A 264
LEU A 266
ILE A 269
 None
 1.01A 4x1gA-4a6eA:
undetectable		 4x1gA-4a6eA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwp PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN-3

(Drosophila
melanogaster) 		no annotation 5 ASP A 550
LEU A 549
LEU A 532
LEU A 480
ILE A 554
 None
 0.99A 4x1gA-4bwpA:
undetectable		 4x1gA-4bwpA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cil YOPM-CAP, INTERNALIN
B

(Listeria
monocytogenes;
Yersinia
enterocolitica) 		PF08191
(LRR_adjacent)
PF12468
(TTSSLRR)
PF12799
(LRR_4) 		5 ASP A 134
LEU A 135
SER A 137
LEU A 149
ILE A 154
 None
 1.05A 4x1gA-4cilA:
undetectable		 4x1gA-4cilA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqd NIKO PROTEIN

(Streptomyces
tendae) 		PF00275
(EPSP_synthase) 		5 ASP A 164
LEU A 165
LEU A 145
ARG A 156
LEU A 157
 None
 0.89A 4x1gA-4fqdA:
undetectable		 4x1gA-4fqdA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0w PROTEASE CSPB

(Clostridium
perfringens) 		no annotation 5 LEU A  81
LEU A  68
ARG A  77
LEU A  75
ILE A  78
 None
 1.11A 4x1gA-4i0wA:
undetectable		 4x1gA-4i0wA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imp POLYKETIDE SYNTHASE
EXTENDER MODULES 3-4

(Saccharopolyspora
spinosa) 		PF08659
(KR) 		5 ASP A 227
LEU A 228
LEU A 240
LEU A 253
ILE A 226
 None
 1.12A 4x1gA-4impA:
undetectable		 4x1gA-4impA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		5 LEU A 322
LEU A 389
SER A 300
LEU A 363
ILE A 361
 None
 1.09A 4x1gA-4j5uA:
undetectable		 4x1gA-4j5uA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans) 		PF00343
(Phosphorylase) 		6 ASP A 257
LEU A 260
LEU A 266
LEU A 255
ILE A 256
MET A 311
 None
 1.46A 4x1gA-4l22A:
undetectable		 4x1gA-4l22A:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		5 ASP A 455
LEU A 456
LEU A 432
ARG A 428
ILE A 430
 None
 0.90A 4x1gA-4lglA:
undetectable		 4x1gA-4lglA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE

(Haemophilus
influenzae) 		PF01380
(SIS) 		5 ASP A 129
LEU A 130
SER A 132
LEU A 141
ILE A  74
 None
 0.70A 4x1gA-4m0dA:
undetectable		 4x1gA-4m0dA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m46 LUCIFERASE

(Lampyris
turkestanicus) 		PF00501
(AMP-binding) 		5 LEU A 253
LEU A 194
MET A 196
ARG A 218
ILE A 215
 None
 1.10A 4x1gA-4m46A:
undetectable		 4x1gA-4m46A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rmf ASPARTATE--TRNA(ASP/
ASN) LIGASE

(Mycolicibacterium
smegmatis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		5 LEU A 266
LEU A 251
PHE A 156
ILE A 476
MET A 233
 None
 1.11A 4x1gA-4rmfA:
undetectable		 4x1gA-4rmfA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME

(Schistosoma
japonicum) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 SER A 106
LEU A 125
MET A 128
ARG A 102
LEU A 158
 None
 1.05A 4x1gA-4wr4A:
undetectable		 4x1gA-4wr4A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkq NICKEL ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Staphylococcus
aureus) 		PF00496
(SBP_bac_5) 		5 LEU A  15
LEU A 464
SER A 228
ARG A 196
ILE A  13
 None
GOL  A 507 ( 4.3A)
GOL  A 513 ( 4.9A)
None
None
 1.11A 4x1gA-4xkqA:
undetectable		 4x1gA-4xkqA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		5 LEU A 575
LEU A 547
ARG A 596
LEU A 566
ILE A 491
 None
 1.03A 4x1gA-4xqkA:
undetectable		 4x1gA-4xqkA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA

(Pseudomonas
fluorescens) 		PF04820
(Trp_halogenase) 		5 LEU A 201
LEU A 224
ARG A 191
LEU A 192
ILE A 198
 None
 0.89A 4x1gA-4z43A:
undetectable		 4x1gA-4z43A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A 589
LEU A 575
SER A 601
LEU A 549
ILE A 546
 None
 0.94A 4x1gA-5b7iA:
undetectable		 4x1gA-5b7iA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c5b DCC-INTERACTING
PROTEIN 13-ALPHA
DCC-INTERACTING
PROTEIN 13-BETA

(Homo sapiens) 		PF00169
(PH)
PF16746
(BAR_3) 		5 ASP B 122
LEU B 123
LEU B  33
ARG B 191
MET A  82
 None
 1.14A 4x1gA-5c5bB:
undetectable		 4x1gA-5c5bB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cmc ML032222A IGLUR

(Mnemiopsis
leidyi) 		PF10613
(Lig_chan-Glu_bd) 		5 ASP A 229
LEU A 232
LEU A  45
LEU A 227
ILE A 228
 None
 1.13A 4x1gA-5cmcA:
undetectable		 4x1gA-5cmcA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dly PLANTAZOLICIN
METHYLTRANSFERASE
BAML

(Bacillus
velezensis) 		PF13847
(Methyltransf_31) 		5 ASP A  66
LEU A  65
LEU A 147
PHE A 196
ILE A  67
 SAH  A 301 ( 4.7A)
None
None
None
None
 0.96A 4x1gA-5dlyA:
undetectable		 4x1gA-5dlyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Cryptococcus
neoformans) 		PF02358
(Trehalose_PPase) 		5 LEU A  62
LEU A  29
PHE A   9
LEU A  52
ILE A  49
 None
 0.97A 4x1gA-5dx9A:
undetectable		 4x1gA-5dx9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmo PROTEIN INDUCED BY
OSMOTIC STRESS

(Scheffersomyces
stipitis) 		PF01370
(Epimerase) 		5 LEU A  14
SER A 188
HIS A  79
LEU A  78
ILE A  18
 None
 1.02A 4x1gA-5gmoA:
undetectable		 4x1gA-5gmoA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grm STIMULATOR OF
INTERFERON GENES
PROTEIN

(Rattus
norvegicus) 		no annotation 5 LEU A 190
LEU A 225
HIS A 308
LEU A 198
ILE A 258
 None
 0.96A 4x1gA-5grmA:
undetectable		 4x1gA-5grmA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8y SULFITE REDUCTASE
[FERREDOXIN],
CHLOROPLASTIC

(Zea mays) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 LEU A 592
LEU A 552
ARG A 517
LEU A 515
ILE A 518
 None
 1.03A 4x1gA-5h8yA:
undetectable		 4x1gA-5h8yA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ha5 BRUCELLA OVIS
OXIDOREDUCTASE

(Brucella ovis) 		PF13561
(adh_short_C2) 		5 ASP A  84
LEU A  81
LEU A 134
LEU A  86
ILE A  85
 None
 1.10A 4x1gA-5ha5A:
undetectable		 4x1gA-5ha5A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikb GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
4,GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
4

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		5 LEU A 181
SER A 183
LEU A 204
SER A 111
ILE A 177
 None
 1.07A 4x1gA-5ikbA:
undetectable		 4x1gA-5ikbA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loy DESIGNED ANBU
PROTEIN

(synthetic
construct) 		PF00227
(Proteasome) 		5 ASP A 192
LEU A 193
LEU A 174
LEU A 189
ILE A 209
 None
 1.09A 4x1gA-5loyA:
undetectable		 4x1gA-5loyA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2g DNA POLYMERASE

(Vaccinia virus) 		no annotation 5 ASP A 867
LEU A 983
PHE A 997
LEU A 872
ILE A 868
 None
 1.09A 4x1gA-5n2gA:
undetectable		 4x1gA-5n2gA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol9 TRANSCRIPTION
ELONGATION FACTOR,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 5 LEU A 115
SER A 125
LEU A  77
ARG A  95
ILE A  99
 None
 1.07A 4x1gA-5ol9A:
undetectable		 4x1gA-5ol9A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfk UNCHARACTERIZED
PROTEIN

(Sulfolobus
solfataricus) 		no annotation 5 LEU A 111
LEU A  95
HIS A 145
LEU A 104
ILE A 103
 None
 0.99A 4x1gA-5vfkA:
undetectable		 4x1gA-5vfkA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4u DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3

(Saccharomyces
cerevisiae) 		no annotation 5 ASP C 117
LEU C 118
LEU C  67
LEU C 153
ILE C 144
 None
 1.07A 4x1gA-5w4uC:
undetectable		 4x1gA-5w4uC:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wxm U3 SMALL NUCLEOLAR
RIBONUCLEOPROTEIN
PROTEIN IMP3
U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN MPP10

(Saccharomyces
cerevisiae) 		PF00163
(Ribosomal_S4)
PF01479
(S4)
PF04006
(Mpp10) 		5 ASP A  53
LEU U 444
LEU A  82
MET A  85
ILE A  54
 None
 1.08A 4x1gA-5wxmA:
undetectable		 4x1gA-5wxmA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yi9 -

(-) 		no annotation 5 LEU A 400
LEU A 377
SER A 409
LEU A 363
ILE A 359
 None
 0.95A 4x1gA-5yi9A:
undetectable		 4x1gA-5yi9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT F

(Flavobacterium
johnsoniae) 		no annotation 5 LEU F 443
SER F 446
LEU F 301
ARG F 144
LEU F 142
 None
 1.07A 4x1gA-6btmF:
undetectable		 4x1gA-6btmF:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5d LLAJI.R1

(Helicobacter
pylori) 		no annotation 5 LEU A  55
LEU A  25
ARG A  60
LEU A  61
ILE A  53
 None
 1.11A 4x1gA-6c5dA:
undetectable		 4x1gA-6c5dA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6du8 -

(-) 		no annotation 6 ASP A 304
SER A 306
LEU A 165
SER A 281
LEU A 200
ILE A 303
 None
 1.30A 4x1gA-6du8A:
undetectable		 4x1gA-6du8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emp -

(-) 		no annotation 5 LEU A 400
LEU A 377
SER A 409
LEU A 363
ILE A 359
 None
 0.94A 4x1gA-6empA:
undetectable		 4x1gA-6empA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emq -

(-) 		no annotation 5 LEU A 400
LEU A 377
SER A 409
LEU A 363
ILE A 359
 None
 0.97A 4x1gA-6emqA:
undetectable		 4x1gA-6emqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6flx ABC TRANSPORTER
SYSTEM, ATP-BINDING
PROTEIN

(Burkholderia
pseudomallei) 		no annotation 5 LEU A 185
SER A 187
LEU A 216
PHE A  74
ILE A 181
 None
 1.00A 4x1gA-6flxA:
undetectable		 4x1gA-6flxA:
13.61