SIMILAR PATTERNS OF AMINO ACIDS FOR 4WW7_A_ACTA305_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 LEU A 797
GLU A 805
ASN A 795
ILE A 790
 None
 0.91A 4ww7A-1hn0A:
2.4		 4ww7A-1hn0A:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i6q LACTOFERRIN

(Camelus
dromedarius) 		PF00405
(Transferrin) 		4 LEU A 230
LEU A 229
GLU A 228
ILE A  97
 None
 0.78A 4ww7A-1i6qA:
0.0		 4ww7A-1i6qA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji0 ABC TRANSPORTER

(Thermotoga
maritima) 		PF00005
(ABC_tran) 		4 LEU A  26
LEU A   6
GLU A   7
ILE A  62
 None
 0.97A 4ww7A-1ji0A:
0.0		 4ww7A-1ji0A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k61 MATING-TYPE PROTEIN
ALPHA-2

(Saccharomyces
cerevisiae) 		PF00046
(Homeobox) 		4 LEU A 171
LEU A 165
ASN A 168
ILE A 143
 None
 0.95A 4ww7A-1k61A:
undetectable		 4ww7A-1k61A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko7 HPR
KINASE/PHOSPHATASE

(Staphylococcus
xylosus) 		PF02603
(Hpr_kinase_N)
PF07475
(Hpr_kinase_C) 		4 LEU A 198
LEU A 199
GLU A 200
ILE A 207
 None
 0.86A 4ww7A-1ko7A:
undetectable		 4ww7A-1ko7A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krq FERRITIN

(Campylobacter
jejuni) 		PF00210
(Ferritin) 		4 LEU A  70
GLU A  69
ASN A  11
ILE A  14
 None
 0.95A 4ww7A-1krqA:
undetectable		 4ww7A-1krqA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1njk HYPOTHETICAL PROTEIN
YBAW

(Escherichia
coli) 		PF13279
(4HBT_2) 		4 LEU A  24
LEU A  27
GLU A  28
ILE A 104
 None
 0.86A 4ww7A-1njkA:
0.0		 4ww7A-1njkA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA

(Mus musculus) 		PF00102
(Y_phosphatase) 		4 LEU A 737
LEU A 741
ILE A 702
MET A 701
 None
 0.92A 4ww7A-1p15A:
0.0		 4ww7A-1p15A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qz4 HYPOTHETICAL PROTEIN
YCFC

(Escherichia
coli) 		PF04356
(DUF489) 		4 LEU A  92
LEU A  95
GLU A  96
ILE A 142
 None
 0.97A 4ww7A-1qz4A:
undetectable		 4ww7A-1qz4A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r44 D-ALANYL-D-ALANINE
DIPEPTIDASE

(Enterococcus
faecium) 		PF01427
(Peptidase_M15) 		4 LEU A 124
LEU A 126
ILE A 169
MET A 170
 None
 0.95A 4ww7A-1r44A:
0.0		 4ww7A-1r44A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5n EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		4 LEU A 532
LEU A 484
GLU A 485
MET A 471
 None
 0.89A 4ww7A-1r5nA:
0.0		 4ww7A-1r5nA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqw SACCHAROMYCES
CEREVISIAE NIP7P
HOMOLOG

(Homo sapiens) 		PF03657
(UPF0113) 		4 LEU A  63
LEU A  66
ILE A  51
MET A  52
 None
 0.97A 4ww7A-1sqwA:
0.0		 4ww7A-1sqwA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqg CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima) 		PF01627
(Hpt) 		4 LEU A  24
LEU A  27
GLU A  28
ILE A  80
 None
 0.90A 4ww7A-1tqgA:
undetectable		 4ww7A-1tqgA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		4 LEU A 165
LEU A 162
ASN A 285
ILE A 281
 None
 0.86A 4ww7A-1ukcA:
undetectable		 4ww7A-1ukcA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9s DNA POLYMERASE

(Escherichia
virus T7) 		PF00476
(DNA_pol_A) 		4 LEU A 484
LEU A 481
GLU A 480
ILE A 525
 None
 0.74A 4ww7A-1x9sA:
undetectable		 4ww7A-1x9sA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdz METHYLTRANSFERASE
GIDB

(Bacillus
subtilis) 		PF02527
(GidB) 		4 LEU A 152
ASN A 211
ILE A 198
MET A 213
 None
 0.94A 4ww7A-1xdzA:
0.4		 4ww7A-1xdzA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1i PEPTIDOGLYCAN GLCNAC
DEACETYLASE

(Streptococcus
pneumoniae) 		PF01522
(Polysacc_deac_1) 		4 LEU A 182
LEU A 178
GLU A 181
ILE A 220
 None
 0.85A 4ww7A-2c1iA:
undetectable		 4ww7A-2c1iA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cja SERYL-TRNA
SYNTHETASE

(Methanosarcina
barkeri) 		no annotation 4 LEU A 111
GLU A 110
ASN A 124
ILE A 129
 None
 0.94A 4ww7A-2cjaA:
undetectable		 4ww7A-2cjaA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw9 TRANSLOCASE OF INNER
MITOCHONDRIAL
MEMBRANE

(Homo sapiens) 		PF04280
(Tim44) 		4 LEU A 339
LEU A 336
GLU A 335
ILE A 355
 None
 0.88A 4ww7A-2cw9A:
2.8		 4ww7A-2cw9A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehb CALCINEURIN B-LIKE
PROTEIN 4

(Arabidopsis
thaliana) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		4 LEU A  41
LEU A  38
GLU A  40
ILE A 198
 None
 0.93A 4ww7A-2ehbA:
undetectable		 4ww7A-2ehbA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE

(Thermus
thermophilus) 		PF00596
(Aldolase_II) 		4 LEU A  54
LEU A  55
GLU A  56
ILE A  39
 None
 0.96A 4ww7A-2fk5A:
undetectable		 4ww7A-2fk5A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho4 HALOACID
DEHALOGENASE-LIKE
HYDROLASE DOMAIN
CONTAINING 2

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 LEU A 189
LEU A 186
ILE A 216
MET A 218
 None
 0.89A 4ww7A-2ho4A:
undetectable		 4ww7A-2ho4A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it9 HYPOTHETICAL PROTEIN

(Prochlorococcus
marinus) 		PF08848
(DUF1818) 		4 LEU A  89
LEU A  91
GLU A 102
ILE A  31
 None
None
PGE  A 128 (-3.7A)
None
 0.97A 4ww7A-2it9A:
undetectable		 4ww7A-2it9A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mtn HISTONE-LYSINE
N-METHYLTRANSFERASE
2A, PC4 AND
SFRS1-INTERACTING
PROTEIN FUSION

(Homo sapiens) 		PF11467
(LEDGF) 		4 LEU A 380
LEU A 377
GLU A 379
ILE A 359
 None
 0.87A 4ww7A-2mtnA:
undetectable		 4ww7A-2mtnA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nx4 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		4 LEU A 186
LEU A 183
ILE A  95
MET A  93
 None
 0.90A 4ww7A-2nx4A:
undetectable		 4ww7A-2nx4A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF04072
(LCM) 		4 LEU A 214
LEU A 215
GLU A 211
ASN A 177
 None
 0.96A 4ww7A-2ob1A:
undetectable		 4ww7A-2ob1A:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q2e TYPE II DNA
TOPOISOMERASE VI
SUBUNIT A

(Methanosarcina
mazei) 		PF04406
(TP6A_N) 		4 LEU A  20
GLU A  25
ASN A  90
ILE A  89
 None
 0.91A 4ww7A-2q2eA:
undetectable		 4ww7A-2q2eA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4v DIAMINE
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		4 LEU A 127
LEU A  91
GLU A  92
ILE A  94
 ACO  A 306 (-3.3A)
None
None
ACO  A 306 (-3.6A)
 0.80A 4ww7A-2q4vA:
undetectable		 4ww7A-2q4vA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfe CALPAIN-7

(Homo sapiens) 		PF01067
(Calpain_III) 		4 LEU A 774
LEU A 727
GLU A 773
ILE A 729
 BR  A   9 ( 4.1A)
None
None
None
 0.94A 4ww7A-2qfeA:
undetectable		 4ww7A-2qfeA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1h HEMOGLOBIN SUBUNIT
ALPHA-4

(Oncorhynchus
mykiss) 		PF00042
(Globin) 		4 LEU A 106
LEU A 102
ILE A  63
MET A  64
 None
HEM  A 143 (-4.2A)
HEM  A 143 ( 4.6A)
None
 0.89A 4ww7A-2r1hA:
undetectable		 4ww7A-2r1hA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE

(Homo sapiens) 		PF00368
(HMG-CoA_red) 		4 LEU A 851
GLU A 850
ILE A 793
MET A 781
 None
 0.88A 4ww7A-2r4fA:
undetectable		 4ww7A-2r4fA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 LEU G 219
LEU G 216
GLU G 217
ASN G 214
 None
 0.94A 4ww7A-2uv8G:
undetectable		 4ww7A-2uv8G:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A 577
GLU A 576
ASN A 568
ILE A 567
 None
 0.94A 4ww7A-2vwkA:
undetectable		 4ww7A-2vwkA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w20 SIALIDASE A

(Streptococcus
pneumoniae) 		PF13088
(BNR_2) 		4 LEU A 351
LEU A 755
ASN A 753
ILE A 765
 None
 0.92A 4ww7A-2w20A:
undetectable		 4ww7A-2w20A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgb TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR

(Mycolicibacterium
smegmatis) 		PF00440
(TetR_N) 		4 LEU A  88
GLU A  93
ILE A 175
MET A 176
 None
 0.92A 4ww7A-2wgbA:
undetectable		 4ww7A-2wgbA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x6n INTEGRASE

(Simian foamy
virus) 		PF00665
(rve) 		4 LEU A 231
LEU A 234
ILE A 298
MET A 253
 None
 0.95A 4ww7A-2x6nA:
undetectable		 4ww7A-2x6nA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xka FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		4 LEU A 293
LEU A 296
GLU A 297
ILE A 343
 None
 0.84A 4ww7A-2xkaA:
undetectable		 4ww7A-2xkaA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6i COLLAGENASE

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		4 LEU A 325
LEU A 322
GLU A 321
ILE A 290
 None
 0.91A 4ww7A-2y6iA:
undetectable		 4ww7A-2y6iA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ys1 DYNAMIN-2

(Homo sapiens) 		PF00169
(PH) 		4 LEU A  93
GLU A  92
ASN A  18
ILE A  16
 None
 0.88A 4ww7A-2ys1A:
undetectable		 4ww7A-2ys1A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajy ANCESTRAL CONGERIN
CON-ANC

(-) 		PF00337
(Gal-bind_lectin) 		4 LEU A 101
LEU A 100
GLU A  99
ILE A  87
 None
 0.77A 4ww7A-3ajyA:
undetectable		 4ww7A-3ajyA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5n PROTEIN SSO1
PROTEIN TRANSPORT
PROTEIN SEC9

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00804
(Syntaxin)
PF05739
(SNARE)
no annotation 		4 LEU B 200
LEU B 203
GLU B 204
ILE D 601
 None
 0.82A 4ww7A-3b5nB:
undetectable		 4ww7A-3b5nB:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf4 ACETYL-COA
DECARBOXYLASE/SYNTHA
SE ALPHA SUBUNIT

(Methanosarcina
barkeri) 		PF03063
(Prismane) 		4 LEU A 765
LEU A 768
GLU A 769
ILE A 783
 None
 0.94A 4ww7A-3cf4A:
undetectable		 4ww7A-3cf4A:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpj GTP-BINDING PROTEIN
YPT31/YPT8

(Saccharomyces
cerevisiae) 		PF00071
(Ras) 		4 LEU B 111
LEU B 108
GLU B 110
ILE B  91
 None
 0.96A 4ww7A-3cpjB:
undetectable		 4ww7A-3cpjB:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkx REPLICATION PROTEIN
REPB

(Streptococcus
agalactiae) 		PF01719
(Rep_2) 		4 LEU A  26
GLU A  27
ASN A 124
MET A  33
 None
 0.93A 4ww7A-3dkxA:
undetectable		 4ww7A-3dkxA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehf SENSOR KINASE (YOCF
PROTEIN)

(Bacillus
subtilis) 		PF07730
(HisKA_3) 		4 LEU A 250
LEU A 246
GLU A 249
ILE A 316
 None
 0.86A 4ww7A-3ehfA:
undetectable		 4ww7A-3ehfA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehg SENSOR KINASE (YOCF
PROTEIN)

(Bacillus
subtilis) 		no annotation 4 LEU A 250
LEU A 246
GLU A 249
ILE A 316
 None
 0.87A 4ww7A-3ehgA:
undetectable		 4ww7A-3ehgA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixq RIBOSE-5-PHOSPHATE
ISOMERASE A

(Methanocaldococcus
jannaschii) 		PF06026
(Rib_5-P_isom_A) 		4 LEU A 191
GLU A 192
ASN A 204
ILE A 135
 None
 0.71A 4ww7A-3ixqA:
undetectable		 4ww7A-3ixqA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4s FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		4 LEU A 293
LEU A 296
GLU A 297
ILE A 343
 None
 0.82A 4ww7A-3j4sA:
undetectable		 4ww7A-3j4sA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzp ARGININE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF02784
(Orn_Arg_deC_N) 		4 LEU A 557
LEU A 560
GLU A 561
ILE A 570
 None
 0.77A 4ww7A-3nzpA:
undetectable		 4ww7A-3nzpA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0c NISCHARIN

(Homo sapiens) 		PF00787
(PX) 		4 LEU A  92
LEU A  96
GLU A  93
ILE A  35
 None
 0.96A 4ww7A-3p0cA:
undetectable		 4ww7A-3p0cA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp9 PUTATIVE
STREPTOTHRICIN
ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00583
(Acetyltransf_1) 		4 LEU A  33
LEU A  31
GLU A  41
ILE A 156
 None
 0.97A 4ww7A-3pp9A:
undetectable		 4ww7A-3pp9A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4d MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY
POSSIBLE
CHLOROMUCONATE
CYCLOISOMERASE

(Cytophaga
hutchinsonii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 204
LEU A 207
GLU A 208
ILE A 212
 None
 0.92A 4ww7A-3q4dA:
undetectable		 4ww7A-3q4dA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6d PUTATIVE
TRIOSEPHOSPHATE
ISOMERASE

(Coccidioides
immitis) 		PF00121
(TIM) 		4 LEU A  39
GLU A  40
ASN A  43
ILE A  45
 None
 0.94A 4ww7A-3s6dA:
0.9		 4ww7A-3s6dA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s9f TRYPAREDOXIN

(Leishmania
major) 		PF13905
(Thioredoxin_8) 		4 LEU A  14
LEU A  12
ASN A  93
ILE A  96
 None
None
MG  A 148 (-4.2A)
MG  A 148 (-4.5A)
 0.89A 4ww7A-3s9fA:
undetectable		 4ww7A-3s9fA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slr UNCHARACTERIZED
PROTEIN BF1531

(Bacteroides
fragilis) 		no annotation 4 LEU A 114
LEU A 115
ILE A  65
MET A  66
 None
 0.73A 4ww7A-3slrA:
undetectable		 4ww7A-3slrA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL-COENZYME M
REDUCTASE, BETA
SUBUNIT

(uncultured
archaeon) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 LEU B  47
LEU B  50
GLU B  51
ILE B 137
 None
 0.72A 4ww7A-3sqgB:
undetectable		 4ww7A-3sqgB:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sy8 ROCR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF00563
(EAL) 		4 LEU A  65
LEU A  68
ILE A  98
MET A  97
 None
 0.93A 4ww7A-3sy8A:
undetectable		 4ww7A-3sy8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulq TRANSCRIPTIONAL
REGULATORY PROTEIN
COMA

(Bacillus
subtilis) 		PF00196
(GerE) 		4 LEU B 189
GLU B 186
ASN B 171
ILE B 174
 None
 0.97A 4ww7A-3ulqB:
undetectable		 4ww7A-3ulqB:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va6 TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 LEU A 665
LEU A 705
GLU A 704
ILE A 739
 None
 0.95A 4ww7A-3va6A:
undetectable		 4ww7A-3va6A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnx FERRITIN

(Ulva pertusa) 		PF00210
(Ferritin) 		4 LEU A 106
GLU A 105
ASN A  45
ILE A  48
 None
 0.86A 4ww7A-3vnxA:
undetectable		 4ww7A-3vnxA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmd PROBABLE MONENSIN
BIOSYNTHESIS
ISOMERASE

(Streptomyces
cinnamonensis) 		PF12680
(SnoaL_2) 		4 LEU A  58
LEU A  62
ASN A  18
ILE A  17
 None
 0.94A 4ww7A-3wmdA:
0.1		 4ww7A-3wmdA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ziz GH5
ENDO-BETA-1,4-MANNAN
ASE

(Podospora
anserina) 		PF00150
(Cellulase) 		4 LEU A 110
LEU A 166
GLU A 165
ILE A 200
 None
 0.92A 4ww7A-3zizA:
undetectable		 4ww7A-3zizA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4are COLLAGENASE G

(Hathewaya
histolytica) 		PF01752
(Peptidase_M9)
PF08453
(Peptidase_M9_N) 		4 LEU A 325
LEU A 322
GLU A 321
ILE A 290
 None
 0.96A 4ww7A-4areA:
undetectable		 4ww7A-4areA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az9 SORTING NEXIN-24

(Homo sapiens) 		PF00787
(PX) 		4 LEU A  78
LEU A  82
GLU A  79
ILE A  24
 None
 0.94A 4ww7A-4az9A:
undetectable		 4ww7A-4az9A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b5d CAPITELLA TELETA
ACHBP

(Capitella
teleta) 		PF02931
(Neur_chan_LBD) 		4 LEU A  42
LEU A 173
ASN A 185
ILE A 182
 None
 0.93A 4ww7A-4b5dA:
1.3		 4ww7A-4b5dA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bj1 PROTEIN RIF2

(Saccharomyces
cerevisiae) 		no annotation 4 LEU A 236
LEU A 239
GLU A 240
ASN A 108
 None
 0.94A 4ww7A-4bj1A:
undetectable		 4ww7A-4bj1A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iy9 30K PROTEIN 1

(Bombyx mori) 		PF03260
(Lipoprotein_11) 		4 LEU A  10
LEU A  14
GLU A  11
ILE A  42
 None
 0.97A 4ww7A-4iy9A:
undetectable		 4ww7A-4iy9A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbd PROLINE RACEMASE

(Pseudomonas
putida) 		PF05544
(Pro_racemase) 		4 LEU A 190
LEU A 193
GLU A 194
ILE A 206
 None
 0.91A 4ww7A-4jbdA:
0.2		 4ww7A-4jbdA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		4 LEU A 215
LEU A 212
ILE A 324
MET A 430
 None
 0.98A 4ww7A-4l87A:
undetectable		 4ww7A-4l87A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4g ZINC FINGER MYND
DOMAIN-CONTAINING
PROTEIN 11

(Mus musculus) 		PF00439
(Bromodomain)
PF00855
(PWWP) 		4 LEU A 255
LEU A 252
GLU A 254
ILE A 165
 None
 0.96A 4ww7A-4n4gA:
undetectable		 4ww7A-4n4gA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzp ARGININOSUCCINATE
SYNTHASE

(Campylobacter
jejuni) 		PF00764
(Arginosuc_synth) 		4 LEU A 226
GLU A 225
ASN A 237
ILE A 236
 None
 0.91A 4ww7A-4nzpA:
undetectable		 4ww7A-4nzpA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4on3 SORTING NEXIN-10

(Homo sapiens) 		PF00787
(PX) 		4 LEU A  98
LEU A 102
GLU A  99
ILE A  34
 None
None
None
NA  A 315 (-4.7A)
 0.81A 4ww7A-4on3A:
undetectable		 4ww7A-4on3A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 LEU A 331
LEU A 327
GLU A 330
ILE A  73
 None
 0.86A 4ww7A-4p4sA:
undetectable		 4ww7A-4p4sA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 LEU B 331
LEU B 327
GLU B 330
ILE B  73
 None
 0.76A 4ww7A-4p4sB:
undetectable		 4ww7A-4p4sB:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00342
(PGI) 		4 LEU A 181
GLU A 183
ILE A 340
MET A 339
 None
 0.96A 4ww7A-4qfhA:
undetectable		 4ww7A-4qfhA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhi UNCHARACTERIZED
PROTEIN MJ1213

(Methanocaldococcus
jannaschii) 		PF01435
(Peptidase_M48) 		4 LEU A  71
LEU A  67
GLU A  70
ILE A  29
 None
None
GOL  A 202 (-3.1A)
None
 0.91A 4ww7A-4qhiA:
undetectable		 4ww7A-4qhiA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rap GLYCOSYLTRANSFERASE
TIBC

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		4 LEU A 248
LEU A 245
ASN A 380
ILE A 383
 None
 0.87A 4ww7A-4rapA:
undetectable		 4ww7A-4rapA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4twf CYS-LOOP
LIGAND-GATED ION
CHANNEL

(Dickeya
chrysanthemi) 		PF02931
(Neur_chan_LBD) 		4 LEU A 130
LEU A 128
GLU A 129
ASN A  80
 None
 0.88A 4ww7A-4twfA:
undetectable		 4ww7A-4twfA:
22.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ww7 EKC/KEOPS COMPLEX
SUBUNIT BUD32

(Saccharomyces
cerevisiae) 		PF06293
(Kdo) 		6 LEU A 199
LEU A 202
GLU A 203
ASN A 218
ILE A 221
MET A 222
 ACT  A 305 (-4.1A)
ACT  A 305 ( 4.1A)
None
ACT  A 305 (-3.5A)
ACT  A 305 ( 3.7A)
ACT  A 305 (-3.5A)
 0.00A 4ww7A-4ww7A:
40.9		 4ww7A-4ww7A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxj GLUTAMATE RECEPTOR
IIB,GLUTAMATE
RECEPTOR IIB

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		4 LEU A 256
LEU A 253
GLU A 252
MET A  49
 None
 0.88A 4ww7A-4wxjA:
undetectable		 4ww7A-4wxjA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeu CYS-LOOP
LIGAND-GATED ION
CHANNEL,PROTON-GATED
ION CHANNEL

(Dickeya
chrysanthemi;
Gloeobacter
violaceus) 		PF02931
(Neur_chan_LBD) 		4 LEU A 130
LEU A 128
GLU A 129
ASN A  80
 None
 0.92A 4ww7A-4yeuA:
undetectable		 4ww7A-4yeuA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yh7 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA

(Mus musculus) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3) 		4 LEU A 592
LEU A 556
GLU A 555
ILE A 571
 None
 0.81A 4ww7A-4yh7A:
undetectable		 4ww7A-4yh7A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00144
(Beta-lactamase) 		4 LEU B 350
GLU B 346
ASN B  22
ILE B  24
 MLY  B 349 ( 4.6A)
MLY  B 349 ( 4.5A)
None
MLY  B 340 ( 4.7A)
 0.94A 4ww7A-5eviB:
undetectable		 4ww7A-5eviB:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 LEU A 292
GLU A 289
ASN A 333
ILE A 332
 None
 0.74A 4ww7A-5fkuA:
undetectable		 4ww7A-5fkuA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iuj SENSOR HISTIDINE
KINASE DESK

(Bacillus
subtilis) 		PF07730
(HisKA_3) 		4 LEU A 250
LEU A 246
GLU A 249
ILE A 316
 None
 0.97A 4ww7A-5iujA:
undetectable		 4ww7A-5iujA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixf SIGNAL TRANSDUCING
ADAPTER MOLECULE 2

(Homo sapiens) 		PF00018
(SH3_1) 		4 LEU A 228
LEU A 257
GLU A 227
ASN A 226
 None
 0.74A 4ww7A-5ixfA:
undetectable		 4ww7A-5ixfA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyg ACTIN-LIKE ATPASE

(Magnetospirillum
magneticum) 		PF06723
(MreB_Mbl) 		4 LEU A 269
LEU A 268
ASN A 156
ILE A 158
 None
 0.93A 4ww7A-5jygA:
undetectable		 4ww7A-5jygA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kf7 BIFUNCTIONAL PROTEIN
PUTA

(Sinorhizobium
meliloti) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 LEU A 317
LEU A 320
GLU A 321
ILE A 353
 None
 0.96A 4ww7A-5kf7A:
undetectable		 4ww7A-5kf7A:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksw DIHYDROOROTATE
DEHYDROGENASE B
(NAD(+)), ELECTRON
TRANSFER SUBUNIT

(Lactococcus
lactis) 		PF00175
(NAD_binding_1)
PF10418
(DHODB_Fe-S_bind) 		4 LEU B 132
GLU B 133
ASN B 162
MET B 139
 None
 0.87A 4ww7A-5kswB:
undetectable		 4ww7A-5kswB:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltg AUTOPHAGY-RELATED
PROTEIN 18

(Ogataea angusta) 		no annotation 4 LEU A 115
LEU A 101
GLU A 114
ILE A 103
 None
 0.93A 4ww7A-5ltgA:
undetectable		 4ww7A-5ltgA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7o NITROGEN
ASSIMILATION
REGULATORY PROTEIN

(Brucella
abortus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat)
PF02954
(HTH_8) 		4 LEU A  67
LEU A  64
ILE A  54
MET A  81
 None
 0.89A 4ww7A-5m7oA:
undetectable		 4ww7A-5m7oA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ub8 LIKELY RAB FAMILY
GTP-BINDING PROTEIN

(Candida
albicans) 		PF00071
(Ras) 		4 LEU A 113
LEU A 110
GLU A 112
ILE A  93
 None
None
ZN  A 303 (-2.6A)
None
 0.97A 4ww7A-5ub8A:
undetectable		 4ww7A-5ub8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w70 L-GLUTAMINE:2-DEOXY-
SCYLLO-INOSOSE
AMINOTRANSFERASE

(Streptomyces
ribosidificus) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A 398
LEU A 393
ILE A 408
MET A 405
 None
 0.83A 4ww7A-5w70A:
undetectable		 4ww7A-5w70A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1z PROTEIN KINASE
C-BINDING PROTEIN 1

(Homo sapiens) 		no annotation 4 LEU C 158
LEU C 157
ILE C 252
MET C 249
 None
 0.98A 4ww7A-5y1zC:
undetectable		 4ww7A-5y1zC:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yd0 SCHLAFEN 8

(Rattus
norvegicus) 		no annotation 4 LEU A  78
LEU A  82
GLU A  79
ILE A 106
 None
 0.93A 4ww7A-5yd0A:
undetectable		 4ww7A-5yd0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cp0 -

(-) 		no annotation 4 LEU A 412
GLU A 415
ASN A 404
ILE A 403
 None
 0.98A 4ww7A-6cp0A:
undetectable		 4ww7A-6cp0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ey5 T9SS COMPONENT
CYTOPLASMIC MEMBRANE
PROTEIN PORM

(Porphyromonas
gingivalis) 		no annotation 4 LEU A 395
GLU A 374
ASN A 353
ILE A 352
 None
 0.97A 4ww7A-6ey5A:
undetectable		 4ww7A-6ey5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml RUVB-LIKE HELICASE
INO80

(Chaetomium
thermophilum;
Chaetomium
thermophilum) 		no annotation
no annotation 		4 LEU G1458
LEU G1461
ASN D 250
ILE D 246
 None
 0.73A 4ww7A-6fmlG:
undetectable		 4ww7A-6fmlG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwv -

(-) 		no annotation 4 LEU A 300
LEU A 262
GLU A 299
ILE A 264
 None
 0.97A 4ww7A-6fwvA:
1.8		 4ww7A-6fwvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gru ADP-SUGAR
PYROPHOSPHATASE

(Homo sapiens) 		no annotation 4 LEU A 110
LEU A 113
GLU A 114
ILE A 148
 None
 0.86A 4ww7A-6gruA:
undetectable		 4ww7A-6gruA:
undetectable