SIMILAR PATTERNS OF AMINO ACIDS FOR 4WQL_A_KANA203_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		5 ASP A 428
ASP A 398
ILE A 574
TYR A 394
GLU A 387
 None
 1.35A 4wqlA-1lzxA:
3.0		 4wqlA-1lzxA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ml4 ASPARTATE
TRANSCARBAMOYLASE

(Pyrococcus
abyssi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ASP A 272
TYR A 241
ASP A 163
TYR A 166
GLU A 233
 None
 1.22A 4wqlA-1ml4A:
0.0		 4wqlA-1ml4A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u02 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE
RELATED PROTEIN

(Thermoplasma
acidophilum) 		PF02358
(Trehalose_PPase) 		5 ASP A 179
ASP A   7
ASP A 183
ILE A  63
GLU A 153
 MG  A 240 (-2.5A)
MG  A 240 (-2.5A)
MG  A 240 ( 4.5A)
None
None
 1.29A 4wqlA-1u02A:
0.1		 4wqlA-1u02A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux6 THROMBOSPONDIN-1

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C) 		5 ASP A 915
ASP A 919
ASP A 917
TYR A1147
GLU A1148
 CA  A2002 (-3.1A)
CA  A2002 ( 2.7A)
CA  A2002 ( 2.8A)
None
None
 1.37A 4wqlA-1ux6A:
0.0		 4wqlA-1ux6A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hoq PUTATIVE
HAD-HYDROLASE PH1655

(Pyrococcus
horikoshii) 		PF13419
(HAD_2) 		5 ASP A 175
ASP A   8
ASP A 180
ILE A 155
ASP A 118
 None
 1.23A 4wqlA-2hoqA:
0.0		 4wqlA-2hoqA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhp THROMBOSPONDIN-2

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C)
PF07645
(EGF_CA)
PF12947
(EGF_3) 		5 ASP A 935
ASP A 939
ASP A 937
TYR A1167
GLU A1168
 CA  A   2 (-3.2A)
CA  A1173 ( 2.9A)
CA  A   2 ( 2.6A)
None
None
 1.35A 4wqlA-2rhpA:
0.0		 4wqlA-2rhpA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewd ADENOSINE DEAMINASE

(Plasmodium
vivax) 		PF00962
(A_deaminase) 		5 ASP A 310
ASP A 309
GLU A 274
ASP A 197
GLU A 202
 MCF  A 372 (-2.9A)
MCF  A 372 ( 2.4A)
None
None
None
 1.24A 4wqlA-3ewdA:
0.1		 4wqlA-3ewdA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgg ADENOSINE DEAMINASE
CECR1

(Homo sapiens) 		PF00962
(A_deaminase)
PF08451
(A_deaminase_N) 		5 ASP A 416
ASP A 415
GLU A 380
ASP A 297
GLU A 302
 CFE  A 513 (-2.8A)
CFE  A 513 ( 2.8A)
None
None
None
 1.07A 4wqlA-3lggA:
0.0		 4wqlA-3lggA:
16.37