SIMILAR PATTERNS OF AMINO ACIDS FOR 4WQD_A_GAIA1005

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxi MALATE DEHYDROGENASE

(Chloroflexus
aurantiacus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ARG A  88
ARG A  82
GLY A 212
ARG A 151
 FUM  A1311 (-4.0A)
FUM  A1311 (-3.6A)
None
FUM  A1311 (-2.8A)
 0.99A 4wqdA-1uxiA:
0.0		 4wqdA-1uxiA:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hr3 PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF13463
(HTH_27) 		4 ARG A 108
ARG A 111
GLY A  42
ARG A  46
 None
 1.42A 4wqdA-2hr3A:
0.0		 4wqdA-2hr3A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vg2 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF01255
(Prenyltransf) 		4 ARG A  89
ARG A 127
GLY A  77
ARG A  80
 DPO  A1297 (-2.7A)
DPO  A1297 ( 3.0A)
DPO  A1297 (-3.0A)
DPO  A1297 (-3.8A)
 0.90A 4wqdA-2vg2A:
0.0		 4wqdA-2vg2A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uti QUEUINE
TRNA-RIBOSYLTRANSFER
ASE

(Zymomonas
mobilis) 		no annotation 4 ARG A  38
ARG A 362
GLY A  63
ARG A  60
 None
 1.44A 4wqdA-5utiA:
0.0		 4wqdA-5utiA:
undetectable