SIMILAR PATTERNS OF AMINO ACIDS FOR 4WQ4_B_ACTB403

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a04 NITRATE/NITRITE
RESPONSE REGULATOR
PROTEIN NARL

(Escherichia
coli) 		PF00072
(Response_reg)
PF00196
(GerE) 		3 ARG A  75
ASP A  72
ARG A 101
 None
 0.57A 4wq4B-1a04A:
1.3		 4wq4B-1a04A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eb3 5-AMINOLAEVULINIC
ACID DEHYDRATASE

(Saccharomyces
cerevisiae) 		PF00490
(ALAD) 		3 ARG A 185
ASP A 188
ARG A 187
 None
 0.63A 4wq4B-1eb3A:
0.4		 4wq4B-1eb3A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imt INTESTINAL TOXIN 1

(Dendroaspis
polylepis) 		PF06607
(Prokineticin) 		3 ARG A   9
ASP A  10
ARG A  54
 None
 0.66A 4wq4B-1imtA:
undetectable		 4wq4B-1imtA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1in0 YAJQ PROTEIN

(Haemophilus
influenzae) 		PF04461
(DUF520) 		3 ARG A  33
ASP A  31
ARG A  29
 None
 0.55A 4wq4B-1in0A:
undetectable		 4wq4B-1in0A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfd INORGANIC
PYROPHOSPHATASE

(Escherichia
coli) 		PF00719
(Pyrophosphatase) 		3 ARG A  88
ASP A  14
ARG A  86
 None
 0.61A 4wq4B-1jfdA:
0.0		 4wq4B-1jfdA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl2 CHIMERA OF
RIBONUCLEASE HI,
RIBONUCLEASE H

(Thermus
thermophilus;
Escherichia
coli) 		PF00075
(RNase_H) 		3 ARG A  41
ASP A 149
ARG A  46
 None
 0.58A 4wq4B-1jl2A:
1.4		 4wq4B-1jl2A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ln1 PHOSPHATIDYLCHOLINE
TRANSFER PROTEIN

(Homo sapiens) 		PF01852
(START) 		3 ARG A 121
ASP A 122
ARG A 120
 None
 0.59A 4wq4B-1ln1A:
0.0		 4wq4B-1ln1A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mr2 ADPR PYROPHOSPHATASE

(Mycobacterium
tuberculosis) 		PF00293
(NUDIX) 		3 ARG A  24
ASP A  25
ARG A  23
 None
 0.67A 4wq4B-1mr2A:
0.0		 4wq4B-1mr2A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus) 		PF02332
(Phenol_Hydrox) 		3 ARG B   9
ASP B  13
ARG B   8
 None
 0.56A 4wq4B-1mtyB:
0.7		 4wq4B-1mtyB:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw9 DNA TOPOISOMERASE I

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 ARG X 448
ASP X 447
ARG X 427
 None
 0.69A 4wq4B-1mw9X:
undetectable		 4wq4B-1mw9X:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		3 ARG A  50
ASP A  43
ARG A 628
 None
 0.62A 4wq4B-1ogyA:
1.8		 4wq4B-1ogyA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA

(Mus musculus) 		PF00102
(Y_phosphatase) 		3 ARG A 666
ASP A 667
ARG A 682
 None
 0.65A 4wq4B-1p15A:
undetectable		 4wq4B-1p15A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjq SIROHEME SYNTHASE

(Salmonella
enterica) 		PF00590
(TP_methylase)
PF10414
(CysG_dimeriser)
PF13241
(NAD_binding_7)
PF14824
(Sirohm_synth_M) 		3 ARG A  13
ASP A  14
ARG A  37
 None
 0.44A 4wq4B-1pjqA:
undetectable		 4wq4B-1pjqA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1reg T4 REGA

(Escherichia
virus T4) 		PF01818
(Translat_reg) 		3 ARG X  70
ASP X  72
ARG X  71
 None
 0.64A 4wq4B-1regX:
undetectable		 4wq4B-1regX:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8h YLMD PROTEIN
SEQUENCE HOMOLOGUE

(Geobacillus
stearothermophilus) 		PF02578
(Cu-oxidase_4) 		3 ARG A 257
ASP A 256
ARG A 255
 None
 0.64A 4wq4B-1t8hA:
undetectable		 4wq4B-1t8hA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2e 2-HYDROXY-6-KETONONA
-2,4-DIENEDIOIC ACID
HYDROLASE

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		3 ARG A 196
ASP A 197
ARG A 195
 None
 0.58A 4wq4B-1u2eA:
undetectable		 4wq4B-1u2eA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuf ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN YAHK

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ARG A 287
ASP A 261
ARG A 286
 None
 0.70A 4wq4B-1uufA:
undetectable		 4wq4B-1uufA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs0 PUTATIVE DNA
LIGASE-LIKE PROTEIN
RV0938/MT0965

(Mycobacterium
tuberculosis) 		PF01068
(DNA_ligase_A_M)
PF04679
(DNA_ligase_A_C) 		3 ARG A 620
ASP A 621
ARG A 619
 None
 0.53A 4wq4B-1vs0A:
undetectable		 4wq4B-1vs0A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vyn ARGONAUTE2

(Drosophila
melanogaster) 		PF02170
(PAZ) 		3 ARG A  30
ASP A  27
ARG A  31
 None
 0.60A 4wq4B-1vynA:
undetectable		 4wq4B-1vynA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wp9 ATP-DEPENDENT RNA
HELICASE, PUTATIVE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ARG A   5
ASP A   6
ARG A   4
 None
 0.64A 4wq4B-1wp9A:
undetectable		 4wq4B-1wp9A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwv DER F II

(Dermatophagoides
farinae) 		PF02221
(E1_DerP2_DerF2) 		3 ARG A 128
ASP A 129
ARG A  31
 None
 0.58A 4wq4B-1xwvA:
undetectable		 4wq4B-1xwvA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd8 ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA3

(Homo sapiens) 		PF03127
(GAT) 		3 ARG G 259
ASP G 284
ARG G 288
 None
 0.36A 4wq4B-1yd8G:
undetectable		 4wq4B-1yd8G:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yni SUCCINYLARGININE
DIHYDROLASE

(Escherichia
coli) 		PF04996
(AstB) 		3 ARG A 403
ASP A 404
ARG A  39
 None
 0.61A 4wq4B-1yniA:
undetectable		 4wq4B-1yniA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z01 2-OXO-1,2-DIHYDROQUI
NOLINE
8-MONOOXYGENASE,
OXYGENASE COMPONENT

(Pseudomonas
putida) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		3 ARG A  72
ASP A  56
ARG A  71
 None
 0.65A 4wq4B-1z01A:
undetectable		 4wq4B-1z01A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbm HYPOTHETICAL PROTEIN
AF1704

(Archaeoglobus
fulgidus) 		PF02621
(VitK2_biosynth) 		3 ARG A 181
ASP A 182
ARG A 180
 None
 0.55A 4wq4B-1zbmA:
undetectable		 4wq4B-1zbmA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfv HUMAN PROTEIN
TYROSINE PHOSPHATASE
RECEPTOR TYPE J

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A1180
ASP A1181
ARG A1196
 None
 0.52A 4wq4B-2cfvA:
undetectable		 4wq4B-2cfvA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvj THIOREDOXIN
REDUCTASE RELATED
PROTEIN

(Thermus
thermophilus) 		PF00890
(FAD_binding_2)
PF07992
(Pyr_redox_2) 		3 ARG A 120
ASP A 126
ARG A 121
 None
 0.68A 4wq4B-2cvjA:
undetectable		 4wq4B-2cvjA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dch PUTATIVE HOMING
ENDONUCLEASE

(Thermoproteus) 		PF14528
(LAGLIDADG_3) 		3 ARG X  31
ASP X  34
ARG X  30
 None
 0.65A 4wq4B-2dchX:
undetectable		 4wq4B-2dchX:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fo1 LIN-12 PROTEIN

(Caenorhabditis
elegans) 		PF00023
(Ank)
PF12796
(Ank_2) 		3 ARG E1138
ASP E1177
ARG E1176
 None
 0.65A 4wq4B-2fo1E:
undetectable		 4wq4B-2fo1E:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Lactococcus
lactis) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		3 ARG A  69
ASP A  95
ARG A  68
 None
 0.62A 4wq4B-2iyoA:
2.6		 4wq4B-2iyoA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjd RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE EPSILON

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A 567
ASP A 568
ARG A 588
 None
 0.66A 4wq4B-2jjdA:
undetectable		 4wq4B-2jjdA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qn4 ALPHA-AMYLASE/SUBTIL
ISIN INHIBITOR

(Oryza sativa) 		PF00197
(Kunitz_legume) 		3 ARG A 155
ASP A 152
ARG A  37
 None
 0.63A 4wq4B-2qn4A:
undetectable		 4wq4B-2qn4A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E

(Fusarium
graminearum) 		PF02458
(Transferase) 		3 ARG A 436
ASP A 440
ARG A 275
 None
 0.60A 4wq4B-2rkvA:
undetectable		 4wq4B-2rkvA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsb HYALURONOGLUCOSAMINI
DASE

(Oceanicola
granulosus) 		PF07555
(NAGidase) 		3 ARG A  16
ASP A  17
ARG A  15
 None
 0.57A 4wq4B-2xsbA:
1.9		 4wq4B-2xsbA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4

(Homo sapiens) 		PF00443
(UCH) 		3 ARG A 923
ASP A 924
ARG A 922
 None
 0.68A 4wq4B-2y6eA:
undetectable		 4wq4B-2y6eA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4t BETA-GALACTOSIDE
ALPHA-2,6-SIALYLTRAN
SFERASE

(Photobacterium
sp. JT-ISH-224) 		PF11477
(PM0188) 		3 ARG A  83
ASP A  36
ARG A 193
 None
 0.55A 4wq4B-2z4tA:
2.0		 4wq4B-2z4tA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zba TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E

(Fusarium
sporotrichioides) 		PF02458
(Transferase) 		3 ARG A 444
ASP A 448
ARG A 283
 None
 0.57A 4wq4B-2zbaA:
undetectable		 4wq4B-2zbaA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3u MENAQUINONE
BIOSYNTHETIC ENZYME

(Thermus
thermophilus) 		PF02621
(VitK2_biosynth) 		3 ARG A 183
ASP A 184
ARG A 182
 None
 0.69A 4wq4B-3a3uA:
undetectable		 4wq4B-3a3uA:
27.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3db2 PUTATIVE
NADPH-DEPENDENT
OXIDOREDUCTASE

(Desulfitobacterium
hafniense) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 ARG A 290
ASP A 291
ARG A 275
 None
 0.66A 4wq4B-3db2A:
undetectable		 4wq4B-3db2A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dew TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Geobacter
sulfurreducens) 		PF00440
(TetR_N) 		3 ARG A 143
ASP A 144
ARG A 142
 EDO  A 207 (-3.9A)
None
None
 0.68A 4wq4B-3dewA:
undetectable		 4wq4B-3dewA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsq PYRROLYSYL-TRNA
SYNTHETASE

(Desulfitobacterium
hafniense) 		PF01409
(tRNA-synt_2d) 		3 ARG A  44
ASP A  43
ARG A  42
 None
 0.61A 4wq4B-3dsqA:
undetectable		 4wq4B-3dsqA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewk SENSOR PROTEIN

(Methylococcus
capsulatus) 		PF13426
(PAS_9) 		3 ARG A 288
ASP A 299
ARG A 287
 None
 0.60A 4wq4B-3ewkA:
undetectable		 4wq4B-3ewkA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm8 GLYCOSIDE HYDROLASE
FAMILY 2, CANDIDATE
BETA-GLYCOSIDASE

(Bacteroides
vulgatus) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 ARG A 399
ASP A 398
ARG A 397
 None
 0.66A 4wq4B-3gm8A:
undetectable		 4wq4B-3gm8A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 ARG A 471
ASP A 467
ARG A 454
 EDO  A 604 (-4.4A)
None
None
 0.60A 4wq4B-3hdxA:
undetectable		 4wq4B-3hdxA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		3 ARG A 207
ASP A 208
ARG A 211
 None
 0.55A 4wq4B-3hpaA:
undetectable		 4wq4B-3hpaA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i36 VASCULAR PROTEIN
TYROSINE PHOSPHATASE
1

(Rattus
norvegicus) 		PF00102
(Y_phosphatase) 		3 ARG A1059
ASP A1060
ARG A1075
 None
 0.44A 4wq4B-3i36A:
undetectable		 4wq4B-3i36A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4q APC40078

(Oleispira
antarctica) 		PF00719
(Pyrophosphatase) 		3 ARG A  89
ASP A  15
ARG A  87
 None
 0.62A 4wq4B-3i4qA:
undetectable		 4wq4B-3i4qA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8b XYLULOSE KINASE

(Bifidobacterium
adolescentis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ARG A 213
ASP A 214
ARG A 212
 None
 0.60A 4wq4B-3i8bA:
12.0		 4wq4B-3i8bA:
25.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6b BETA-AMYLOID-LIKE
PROTEIN

(Caenorhabditis
elegans) 		PF12925
(APP_E2) 		3 ARG A 374
ASP A 373
ARG A 402
 None
 0.68A 4wq4B-3k6bA:
2.4		 4wq4B-3k6bA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nk7 23S RRNA
METHYLTRANSFERASE

(Streptomyces
actuosus) 		PF00588
(SpoU_methylase)
PF04705
(TSNR_N) 		3 ARG A 158
ASP A 157
ARG A 159
 None
 0.67A 4wq4B-3nk7A:
undetectable		 4wq4B-3nk7A:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nr1 HD DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF13328
(HD_4) 		3 ARG A 128
ASP A 129
ARG A 132
 None
 0.57A 4wq4B-3nr1A:
undetectable		 4wq4B-3nr1A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qf2 NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF02758
(PYRIN) 		3 ARG A  81
ASP A  82
ARG A  80
 None
 0.41A 4wq4B-3qf2A:
undetectable		 4wq4B-3qf2A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfk UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		3 ARG A  43
ASP A  42
ARG A 257
 None
 0.67A 4wq4B-3qfkA:
undetectable		 4wq4B-3qfkA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnt NIEMANN-PICK C1-LIKE
PROTEIN 1

(Homo sapiens) 		PF16414
(NPC1_N) 		3 ARG A 174
ASP A 258
ARG A 176
 None
 0.54A 4wq4B-3qntA:
undetectable		 4wq4B-3qntA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7w EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
nitratireducens) 		PF02335
(Cytochrom_C552) 		3 ARG A 322
ASP A 321
ARG A 323
 None
 0.56A 4wq4B-3s7wA:
undetectable		 4wq4B-3s7wA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttb EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
paradoxus) 		PF02335
(Cytochrom_C552) 		3 ARG A 322
ASP A 321
ARG A 323
 None
 0.51A 4wq4B-3ttbA:
undetectable		 4wq4B-3ttbA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3utk LIPOPROTEIN OUTS

(Dickeya
dadantii) 		PF09691
(T2SS_PulS_OutS) 		3 ARG A  58
ASP A  65
ARG A  63
 None
 0.68A 4wq4B-3utkA:
undetectable		 4wq4B-3utkA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vns NRPS ADENYLATION
PROTEIN CYTC1

(Streptomyces
sp.) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 ARG A 198
ASP A 197
ARG A 275
 None
 0.70A 4wq4B-3vnsA:
undetectable		 4wq4B-3vnsA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzi CRISPR-ASSOCIATED
PROTEIN CAS5, DVULG
SUBTYPE

(Xanthomonas
oryzae) 		PF09704
(Cas_Cas5d) 		3 ARG A 206
ASP A 184
ARG A 204
 None
 0.70A 4wq4B-3vziA:
undetectable		 4wq4B-3vziA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf8 FPR4

(Saccharomyces
cerevisiae) 		PF00254
(FKBP_C) 		3 ARG A 295
ASP A 294
ARG A 358
 None
 0.68A 4wq4B-4bf8A:
undetectable		 4wq4B-4bf8A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL

(Homo sapiens) 		PF02146
(SIR2) 		3 ARG A 358
ASP A 359
ARG A 340
 None
 0.60A 4wq4B-4bn5A:
undetectable		 4wq4B-4bn5A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hga HISTONE H3.3

(Homo sapiens) 		PF00125
(Histone) 		3 ARG B 128
ASP B 106
ARG B 134
 None
 0.48A 4wq4B-4hgaB:
undetectable		 4wq4B-4hgaB:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxw DNA GYRASE SUBUNIT B

(Enterococcus
faecalis) 		PF02518
(HATPase_c) 		3 ARG A 217
ASP A 216
ARG A 218
 None
 0.67A 4wq4B-4hxwA:
undetectable		 4wq4B-4hxwA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ict CYTOCHROME P450 121

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		3 ARG A  58
ASP A  57
ARG A  59
 SO4  A 401 (-3.8A)
None
None
 0.63A 4wq4B-4ictA:
undetectable		 4wq4B-4ictA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikc PHOSPHOTIDYLINOSITOL
PHOSPHATASE PTPRQ

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A2824
ASP A2825
ARG A2838
 None
 0.49A 4wq4B-4ikcA:
undetectable		 4wq4B-4ikcA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kmo PUTATIVE VACUOLAR
PROTEIN
SORTING-ASSOCIATED
PROTEIN

(Chaetomium
thermophilum) 		PF04840
(Vps16_C) 		3 ARG B 618
ASP B 617
ARG B 619
 None
 0.63A 4wq4B-4kmoB:
undetectable		 4wq4B-4kmoB:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nrh CHAPERONE SYCD

(Chlamydia
pneumoniae) 		PF07720
(TPR_3) 		3 ARG B 118
ASP B 119
ARG B 151
 None
 0.51A 4wq4B-4nrhB:
undetectable		 4wq4B-4nrhB:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz6 TRNA PSEUDOURIDINE
SYNTHASE A,
MITOCHONDRIAL

(Homo sapiens) 		PF01416
(PseudoU_synth_1) 		3 ARG A 385
ASP A 383
ARG A 382
 None
EDO  A 401 (-4.4A)
None
 0.52A 4wq4B-4nz6A:
undetectable		 4wq4B-4nz6A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox0 DEVELOPMENTAL
PROTEIN SEPALLATA 3

(Arabidopsis
thaliana) 		PF01486
(K-box) 		3 ARG A  36
ASP A  45
ARG A  39
 None
 0.44A 4wq4B-4ox0A:
undetectable		 4wq4B-4ox0A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pir 5-HYDROXYTRYPTAMINE
RECEPTOR 3A

(Mus musculus) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		3 ARG A 217
ASP A 145
ARG A 218
 None
 0.43A 4wq4B-4pirA:
undetectable		 4wq4B-4pirA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		3 ARG A 579
ASP A 578
ARG A 580
 None
 0.53A 4wq4B-4pj3A:
undetectable		 4wq4B-4pj3A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18

(Serratia
proteamaculans) 		PF00704
(Glyco_hydro_18) 		3 ARG A 341
ASP A 338
ARG A 342
 None
 0.62A 4wq4B-4q22A:
undetectable		 4wq4B-4q22A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnz CONSERVED
HYPOTHETICAL
SECRETED PROTEIN

(Helicobacter
pylori) 		PF01551
(Peptidase_M23) 		3 ARG A 183
ASP A 184
ARG A 128
 GOL  A 508 ( 3.8A)
None
None
 0.63A 4wq4B-4rnzA:
undetectable		 4wq4B-4rnzA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xel INORGANIC
PYROPHOSPHATASE

(Pseudomonas
aeruginosa) 		PF00719
(Pyrophosphatase) 		3 ARG A  89
ASP A  15
ARG A  87
 None
 0.63A 4wq4B-4xelA:
undetectable		 4wq4B-4xelA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Drosophila
melanogaster) 		PF07034
(ORC3_N) 		3 ARG C 427
ASP C 280
ARG C 426
 None
 0.64A 4wq4B-4xgcC:
undetectable		 4wq4B-4xgcC:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysh GLYCINE OXIDASE

(Geobacillus
kaustophilus) 		PF01266
(DAO) 		3 ARG A 275
ASP A 274
ARG A 276
 None
 0.67A 4wq4B-4yshA:
undetectable		 4wq4B-4yshA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7c S-CRYSTALLIN OCTVUS4

(Octopus
vulgaris) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 ARG A  32
ASP A  31
ARG A  33
 None
 0.51A 4wq4B-5b7cA:
undetectable		 4wq4B-5b7cA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dan 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE

(Thermotoga
maritima) 		PF00248
(Aldo_ket_red) 		3 ARG A  91
ASP A  93
ARG A  92
 None
 0.68A 4wq4B-5danA:
undetectable		 4wq4B-5danA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl8 BENZOATE TRANSPORT
PORIN BENP

(Acinetobacter
baumannii) 		no annotation 3 ARG B 383
ASP B 382
ARG B 368
 None
 0.70A 4wq4B-5dl8B:
undetectable		 4wq4B-5dl8B:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		3 ARG A 327
ASP A 330
ARG A 326
 None
 0.66A 4wq4B-5ej1A:
undetectable		 4wq4B-5ej1A:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ew5 COLICIN-E9

(Escherichia
coli) 		PF03515
(Cloacin) 		3 ARG A 433
ASP A 337
ARG A 432
 None
 0.63A 4wq4B-5ew5A:
undetectable		 4wq4B-5ew5A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyb DNA-BINDING PROTEIN
REB1

(Schizosaccharomyces
pombe) 		PF00249
(Myb_DNA-binding) 		3 ARG A 358
ASP A 355
ARG A 407
 None
 0.62A 4wq4B-5eybA:
undetectable		 4wq4B-5eybA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fah KALLIKREIN-7

(Homo sapiens) 		PF00089
(Trypsin) 		3 ARG A  78
ASP A  77
ARG A  79
 None
 0.61A 4wq4B-5fahA:
undetectable		 4wq4B-5fahA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8y SULFITE REDUCTASE
[FERREDOXIN],
CHLOROPLASTIC

(Zea mays) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 ARG A 361
ASP A 362
ARG A 360
 None
 0.53A 4wq4B-5h8yA:
undetectable		 4wq4B-5h8yA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxi NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4

(Homo sapiens) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		3 ARG A 214
ASP A 145
ARG A 215
 None
 0.68A 4wq4B-5kxiA:
undetectable		 4wq4B-5kxiA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l35 GENE 5 PROTEIN

(Shigella virus
Sf6) 		PF11651
(P22_CoatProtein) 		3 ARG A 386
ASP A 403
ARG A 401
 None
 0.53A 4wq4B-5l35A:
undetectable		 4wq4B-5l35A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6f FAD LINKED
OXIDASE-LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 ARG A 416
ASP A 415
ARG A 373
 None
 0.69A 4wq4B-5l6fA:
undetectable		 4wq4B-5l6fA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lz6 GOLGI RESIDENT
PROTEIN GCP60

(Homo sapiens) 		PF13897
(GOLD_2) 		3 ARG A 485
ASP A 426
ARG A 484
 None
BGC  A 601 (-3.0A)
BGC  A 601 (-4.5A)
 0.62A 4wq4B-5lz6A:
undetectable		 4wq4B-5lz6A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT

(Escherichia
coli) 		PF03814
(KdpA) 		3 ARG A 277
ASP A 276
ARG A 278
 None
 0.63A 4wq4B-5mrwA:
1.7		 4wq4B-5mrwA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2s DDK KINASE
REGULATORY SUBUNIT
DBF4,SERINE/THREONIN
E-PROTEIN KINASE
RAD53

(Saccharomyces
cerevisiae) 		PF00498
(FHA)
PF08630
(Dfp1_Him1_M) 		3 ARG A 249
ASP A 250
ARG A 238
 None
GOL  A 402 ( 2.9A)
GOL  A 402 (-3.8A)
 0.69A 4wq4B-5t2sA:
undetectable		 4wq4B-5t2sA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3b GLYCOSIDE HYDROLASE

(Bacteroides
plebeius) 		no annotation 3 ARG A 245
ASP A 244
ARG A 241
 None
 0.62A 4wq4B-5t3bA:
undetectable		 4wq4B-5t3bA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6n PROTON-GATED ION
CHANNEL

(Gloeobacter
violaceus) 		no annotation 3 ARG C  50
ASP C  49
ARG C  51
 None
 0.65A 4wq4B-5v6nC:
3.1		 4wq4B-5v6nC:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1e PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		no annotation 3 ARG A 469
ASP A 470
ARG A 474
 None
 0.63A 4wq4B-5w1eA:
undetectable		 4wq4B-5w1eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8p HOMOSERINE
O-ACETYLTRANSFERASE

(Mycobacteroides
abscessus) 		PF00561
(Abhydrolase_1) 		3 ARG A  53
ASP A  54
ARG A  52
 PO4  A 406 (-2.9A)
None
None
 0.68A 4wq4B-5w8pA:
undetectable		 4wq4B-5w8pA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wab PUTATIVE
BETA-GLUCOSIDASE

(Bifidobacterium
adolescentis) 		no annotation 3 ARG A 164
ASP A 163
ARG A 166
 None
 0.68A 4wq4B-5wabA:
undetectable		 4wq4B-5wabA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzr ALPHA-N-ACETYLGALACT
OSAMINIDASE

(Bifidobacterium
bifidum) 		PF11308
(Glyco_hydro_129) 		3 ARG A  41
ASP A 111
ARG A 109
 None
 0.67A 4wq4B-5wzrA:
undetectable		 4wq4B-5wzrA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xk8 UNDECAPRENYL
DIPHOSPHATE SYNTHASE

(Streptomyces
sp. CNH189) 		no annotation 3 ARG A 210
ASP A 209
ARG A 211
 None
 0.68A 4wq4B-5xk8A:
undetectable		 4wq4B-5xk8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xpg UNCHARACTERIZED
PROTEIN

(Thermus
thermophilus) 		no annotation 3 ARG A 418
ASP A 417
ARG A 420
 None
 0.62A 4wq4B-5xpgA:
3.2		 4wq4B-5xpgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6erc PEROXINECTIN A

(Dictyostelium
discoideum) 		no annotation 3 ARG A 249
ASP A 250
ARG A 253
 None
 0.55A 4wq4B-6ercA:
undetectable		 4wq4B-6ercA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC1

(Saccharomyces
cerevisiae) 		no annotation 3 ARG A 937
ASP A 627
ARG A 655
 None
 0.55A 4wq4B-6f42A:
undetectable		 4wq4B-6f42A:
undetectable