SIMILAR PATTERNS OF AMINO ACIDS FOR 4WOZ_F_MN9F401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekq HYDROXYETHYLTHIAZOLE
KINASE

(Bacillus
subtilis) 		PF02110
(HK) 		4 LEU A  93
ASP A  94
LEU A 117
THR A 130
 None
 1.24A 4wozF-1ekqA:
2.6
4wozH-1ekqA:
2.7		 4wozF-1ekqA:
23.10
4wozH-1ekqA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epz DTDP-6-DEOXY-D-XYLO-
4-HEXULOSE
3,5-EPIMERASE

(Methanothermobacter
thermautotrophicus) 		PF00908
(dTDP_sugar_isom) 		4 LEU A 178
ASP A 153
TYR A 184
LEU A  89
 None
 1.25A 4wozF-1epzA:
undetectable
4wozH-1epzA:
undetectable		 4wozF-1epzA:
18.75
4wozH-1epzA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3u 3-METHYL-2-OXOBUTANO
ATE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF02548
(Pantoate_transf) 		4 LEU A 163
ASP A 166
LEU A 180
THR A 140
 None
 1.17A 4wozF-1m3uA:
13.5
4wozH-1m3uA:
13.4		 4wozF-1m3uA:
23.77
4wozH-1m3uA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 LEU A 191
ASP A 190
LEU A  22
THR A  48
 None
 1.27A 4wozF-1ofeA:
5.3
4wozH-1ofeA:
7.2		 4wozF-1ofeA:
10.93
4wozH-1ofeA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p0c NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Pelophylax
perezi) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A1306
ASP A1303
LEU A1278
THR A1309
 None
 1.19A 4wozF-1p0cA:
0.2
4wozH-1p0cA:
undetectable		 4wozF-1p0cA:
21.94
4wozH-1p0cA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE

(Mus musculus) 		PF02348
(CTP_transf_3) 		4 LEU A 121
ASP A 122
TYR A 227
LEU A 228
 None
 1.23A 4wozF-1qwjA:
1.9
4wozH-1qwjA:
2.2		 4wozF-1qwjA:
23.64
4wozH-1qwjA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2f PROTEIN
(RIBONUCLEOTIDE
REDUCTASE R2)

(Salmonella
enterica) 		PF00268
(Ribonuc_red_sm) 		4 LEU A 223
ASP A 224
TYR A 267
LEU A 262
 None
 1.15A 4wozF-1r2fA:
undetectable
4wozH-1r2fA:
undetectable		 4wozF-1r2fA:
21.97
4wozH-1r2fA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rep PROTEIN (REPLICATION
INITIATION PROTEIN)

(Escherichia
coli) 		PF01051
(Rep_3) 		4 LEU C 224
TYR C 166
LEU C 169
THR C 220
 None
 0.97A 4wozF-1repC:
0.0
4wozH-1repC:
undetectable		 4wozF-1repC:
19.81
4wozH-1repC:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suv TRANSFERRIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 LEU A 625
ASP A 624
TYR A 643
LEU A 642
 None
 1.23A 4wozF-1suvA:
0.5
4wozH-1suvA:
1.3		 4wozF-1suvA:
17.03
4wozH-1suvA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvz 3-HYDROXY-3-METHYLGL
UTARYL-COA SYNTHASE

(Staphylococcus
aureus) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 LEU A 302
TYR A 282
LEU A 285
THR A 115
 None
 1.26A 4wozF-1tvzA:
undetectable
4wozH-1tvzA:
undetectable		 4wozF-1tvzA:
24.75
4wozH-1tvzA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE

(Homo sapiens) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 LEU A 135
ASP A 132
LEU A 141
THR A 176
 None
 1.27A 4wozF-1v40A:
undetectable
4wozH-1v40A:
undetectable		 4wozF-1v40A:
21.07
4wozH-1v40A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp4 AMINOTRANSFERASE,
PUTATIVE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		4 LEU A 342
TYR A 364
LEU A 382
THR A 350
 None
 1.25A 4wozF-1vp4A:
2.4
4wozH-1vp4A:
2.3		 4wozF-1vp4A:
22.63
4wozH-1vp4A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2u ENDOGLUCANASE

(Humicola grisea) 		PF01670
(Glyco_hydro_12) 		4 LEU A 121
TYR A 190
LEU A 184
THR A 106
 None
 1.05A 4wozF-1w2uA:
undetectable
4wozH-1w2uA:
undetectable		 4wozF-1w2uA:
20.06
4wozH-1w2uA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR

(Sus scrofa) 		PF13516
(LRR_6) 		4 LEU A 400
ASP A 399
LEU A 413
THR A 432
 None
 1.08A 4wozF-2bnhA:
undetectable
4wozH-2bnhA:
undetectable		 4wozF-2bnhA:
20.13
4wozH-2bnhA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3y URACIL-DNA
GLYCOSYLASE

(Thermus
thermophilus) 		PF03167
(UDG) 		4 LEU A 102
ASP A 100
TYR A 105
LEU A 104
 None
None
None
DU  A 221 (-4.1A)
 1.27A 4wozF-2d3yA:
undetectable
4wozH-2d3yA:
undetectable		 4wozF-2d3yA:
20.07
4wozH-2d3yA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		4 LEU A1045
ASP A1042
LEU A1059
THR A1049
 None
 0.84A 4wozF-2ec5A:
undetectable
4wozH-2ec5A:
undetectable		 4wozF-2ec5A:
18.21
4wozH-2ec5A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Caldanaerobacter
subterraneus) 		PF13407
(Peripla_BP_4) 		4 LEU A  53
ASP A  52
LEU A  61
THR A   3
 None
 1.12A 4wozF-2ioyA:
undetectable
4wozH-2ioyA:
undetectable		 4wozF-2ioyA:
22.73
4wozH-2ioyA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j85 STIV B116

(Sulfolobus
turreted
icosahedral
virus 1) 		PF08960
(DUF1874) 		4 LEU A  61
ASP A  98
LEU A  57
THR A  64
 None
 1.26A 4wozF-2j85A:
undetectable
4wozH-2j85A:
undetectable		 4wozF-2j85A:
17.21
4wozH-2j85A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5t PUTATIVE
TRANSCRIPTIONAL
REGULATOR PEZA

(Streptococcus
pneumoniae) 		no annotation 4 LEU A 118
ASP A 117
TYR A  94
LEU A  93
 None
 1.14A 4wozF-2p5tA:
undetectable
4wozH-2p5tA:
undetectable		 4wozF-2p5tA:
20.98
4wozH-2p5tA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph3 3-OXOACYL-[ACYL
CARRIER PROTEIN]
REDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		4 LEU A  21
ASP A  24
LEU A  28
THR A  83
 None
 1.24A 4wozF-2ph3A:
undetectable
4wozH-2ph3A:
3.6		 4wozF-2ph3A:
24.44
4wozH-2ph3A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2quq CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
B

(Saccharomyces
cerevisiae) 		PF16846
(Cep3) 		4 LEU A 370
ASP A 371
TYR A 358
LEU A 355
 None
 1.12A 4wozF-2quqA:
undetectable
4wozH-2quqA:
undetectable		 4wozF-2quqA:
21.73
4wozH-2quqA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		4 LEU A 384
TYR A 255
LEU A 254
THR A 388
 None
 1.20A 4wozF-2r9hA:
undetectable
4wozH-2r9hA:
undetectable		 4wozF-2r9hA:
19.33
4wozH-2r9hA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2reu TYPE II RESTRICTION
ENZYME SAU3AI

(Staphylococcus
aureus) 		no annotation 4 ASP A 135
TYR A  40
LEU A  38
THR A  74
 None
 1.25A 4wozF-2reuA:
undetectable
4wozH-2reuA:
undetectable		 4wozF-2reuA:
23.68
4wozH-2reuA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5o ALPHA-L-ARABINOFURAN
OSIDASE

(Fusarium
graminearum) 		no annotation 4 LEU A 130
ASP A 129
LEU A 160
THR A 133
 None
 1.03A 4wozF-2w5oA:
undetectable
4wozH-2w5oA:
undetectable		 4wozF-2w5oA:
21.90
4wozH-2w5oA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 LEU A 344
ASP A 341
TYR A 351
LEU A 348
 None
None
HDD  A 690 (-3.7A)
None
 0.98A 4wozF-2xf2A:
undetectable
4wozH-2xf2A:
undetectable		 4wozF-2xf2A:
17.91
4wozH-2xf2A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3v SPINDLE ASSEMBLY
ABNORMAL PROTEIN 6
HOMOLOG

(Danio rerio) 		PF16531
(SAS-6_N) 		4 LEU A  54
TYR A 152
LEU A 153
THR A  49
 None
 1.28A 4wozF-2y3vA:
undetectable
4wozH-2y3vA:
undetectable		 4wozF-2y3vA:
22.37
4wozH-2y3vA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8c DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Plasmodium
falciparum) 		PF00692
(dUTPase) 		4 LEU A 120
TYR A 128
LEU A  39
THR A  97
 None
 1.09A 4wozF-2y8cA:
undetectable
4wozH-2y8cA:
undetectable		 4wozF-2y8cA:
22.90
4wozH-2y8cA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yuq TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF00018
(SH3_1) 		4 LEU A  36
TYR A  28
LEU A  38
THR A  30
 None
 1.27A 4wozF-2yuqA:
undetectable
4wozH-2yuqA:
undetectable		 4wozF-2yuqA:
14.39
4wozH-2yuqA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvx MG2+ TRANSPORTER
MGTE

(Thermus
thermophilus) 		PF00571
(CBS)
PF01769
(MgtE)
PF03448
(MgtE_N) 		4 LEU A 189
ASP A 188
LEU A 155
THR A 196
 None
 1.27A 4wozF-2yvxA:
undetectable
4wozH-2yvxA:
undetectable		 4wozF-2yvxA:
21.01
4wozH-2yvxA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z3t CYTOCHROME P450

(Streptomyces
sp. TP-A0274) 		PF00067
(p450) 		4 LEU A  11
ASP A  10
LEU A 328
THR A 305
 None
 1.22A 4wozF-2z3tA:
undetectable
4wozH-2z3tA:
undetectable		 4wozF-2z3tA:
20.97
4wozH-2z3tA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a62 RIBOSOMAL PROTEIN S6
KINASE BETA-1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 282
ASP A 285
TYR A 198
LEU A 199
 None
 1.18A 4wozF-3a62A:
undetectable
4wozH-3a62A:
undetectable		 4wozF-3a62A:
22.04
4wozH-3a62A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ag6 PANTOTHENATE
SYNTHETASE

(Staphylococcus
aureus) 		PF02569
(Pantoate_ligase) 		4 LEU A 203
ASP A 276
TYR A 231
LEU A 232
 None
 1.18A 4wozF-3ag6A:
undetectable
4wozH-3ag6A:
undetectable		 4wozF-3ag6A:
24.10
4wozH-3ag6A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dr8 YNCA

(Salmonella
enterica) 		PF13420
(Acetyltransf_4) 		4 LEU A 162
ASP A 163
LEU A 160
THR A  80
 None
 1.13A 4wozF-3dr8A:
undetectable
4wozH-3dr8A:
undetectable		 4wozF-3dr8A:
22.37
4wozH-3dr8A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1t HALOGENASE

(Chondromyces
crocatus) 		PF04820
(Trp_halogenase) 		4 LEU A 117
ASP A 114
LEU A  64
THR A  54
 None
 1.28A 4wozF-3e1tA:
undetectable
4wozH-3e1tA:
undetectable		 4wozF-3e1tA:
21.84
4wozH-3e1tA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e38 TWO-DOMAIN PROTEIN
CONTAINING PREDICTED
PHP-LIKE
METAL-DEPENDENT
PHOSPHOESTERASE

(Bacteroides
vulgatus) 		PF16392
(DUF5001) 		4 LEU A 269
ASP A 268
TYR A  36
LEU A  33
 None
 1.01A 4wozF-3e38A:
4.2
4wozH-3e38A:
4.0		 4wozF-3e38A:
22.22
4wozH-3e38A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3epu STM2138 VIRULENCE
CHAPERONE

(Salmonella
enterica) 		PF05932
(CesT) 		4 LEU A  28
ASP A  24
LEU A  40
THR A  44
 None
 1.23A 4wozF-3epuA:
undetectable
4wozH-3epuA:
undetectable		 4wozF-3epuA:
19.14
4wozH-3epuA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijt PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		no annotation 4 LEU A 104
ASP A 106
LEU A 117
THR A 110
 None
 1.28A 4wozF-3ijtA:
undetectable
4wozH-3ijtA:
undetectable		 4wozF-3ijtA:
20.61
4wozH-3ijtA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u MAJOR CAPSID PROTEIN

(Bordetella
virus BPP1) 		no annotation 4 LEU A  39
ASP A  40
LEU A 130
THR A 320
 None
 1.23A 4wozF-3j4uA:
undetectable
4wozH-3j4uA:
undetectable		 4wozF-3j4uA:
23.41
4wozH-3j4uA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN US5
40S RIBOSOMAL
PROTEIN ES21

(Plasmodium
falciparum;
Plasmodium
falciparum) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C)
PF01249
(Ribosomal_S21e) 		4 LEU G 241
ASP G 240
LEU Z  23
THR G 245
 None
 1.22A 4wozF-3j7aG:
undetectable
4wozH-3j7aG:
undetectable		 4wozF-3j7aG:
21.99
4wozH-3j7aG:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4u BINDING COMPONENT OF
ABC TRANSPORTER

(Wolinella
succinogenes) 		PF00497
(SBP_bac_3) 		4 LEU A  32
ASP A  29
TYR A 217
LEU A 220
 None
 1.27A 4wozF-3k4uA:
undetectable
4wozH-3k4uA:
undetectable		 4wozF-3k4uA:
22.11
4wozH-3k4uA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzg ARGININE 3RD
TRANSPORT SYSTEM
PERIPLASMIC BINDING
PROTEIN

(Legionella
pneumophila) 		PF00497
(SBP_bac_3) 		4 LEU A  49
ASP A  46
TYR A 237
LEU A 240
 None
 1.06A 4wozF-3kzgA:
undetectable
4wozH-3kzgA:
undetectable		 4wozF-3kzgA:
23.23
4wozH-3kzgA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrg TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Chloroflexus
aurantiacus) 		PF00440
(TetR_N) 		4 LEU A  22
ASP A  19
TYR A  62
LEU A  63
 CL  A 218 ( 4.7A)
None
None
None
 1.22A 4wozF-3nrgA:
undetectable
4wozH-3nrgA:
undetectable		 4wozF-3nrgA:
24.00
4wozH-3nrgA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvq SEMAPHORIN-7A

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI)
PF13895
(Ig_2) 		4 LEU A 490
ASP A 491
TYR A 478
LEU A 477
 None
 1.22A 4wozF-3nvqA:
undetectable
4wozH-3nvqA:
undetectable		 4wozF-3nvqA:
19.90
4wozH-3nvqA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwa ENVELOPE
GLYCOPROTEIN B

(Human
alphaherpesvirus
1) 		no annotation 4 LEU B 330
ASP B 329
TYR B 164
THR B 162
 None
 1.28A 4wozF-3nwaB:
undetectable
4wozH-3nwaB:
undetectable		 4wozF-3nwaB:
17.95
4wozH-3nwaB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pj0 LMO0305 PROTEIN

(Listeria
monocytogenes) 		PF01212
(Beta_elim_lyase) 		4 LEU A  38
ASP A  35
TYR A 242
LEU A 246
 None
 1.21A 4wozF-3pj0A:
undetectable
4wozH-3pj0A:
undetectable		 4wozF-3pj0A:
22.74
4wozH-3pj0A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6t 43.2 KDA SALIVARY
PROTEIN

(Lutzomyia
longipalpis) 		PF03022
(MRJP) 		4 ASP A 332
TYR A   6
LEU A 362
THR A  60
 None
 1.10A 4wozF-3q6tA:
undetectable
4wozH-3q6tA:
undetectable		 4wozF-3q6tA:
19.85
4wozH-3q6tA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttb EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
paradoxus) 		PF02335
(Cytochrom_C552) 		4 LEU A 194
ASP A 195
TYR A 228
THR A  61
 HEC  A1001 ( 3.7A)
None
HEC  A1002 (-3.6A)
SO4  A 533 (-3.8A)
 0.97A 4wozF-3ttbA:
undetectable
4wozH-3ttbA:
undetectable		 4wozF-3ttbA:
20.04
4wozH-3ttbA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttb EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
paradoxus) 		PF02335
(Cytochrom_C552) 		4 LEU A 221
ASP A 220
LEU A 123
THR A  61
 None
None
None
SO4  A 533 (-3.8A)
 0.97A 4wozF-3ttbA:
undetectable
4wozH-3ttbA:
undetectable		 4wozF-3ttbA:
20.04
4wozH-3ttbA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtr N-ACETYLGLUCOSAMINID
ASE

(Ostrinia
furnacalis) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 LEU A 334
TYR A 344
LEU A 345
THR A 311
 None
 1.17A 4wozF-3vtrA:
6.7
4wozH-3vtrA:
10.9		 4wozF-3vtrA:
19.31
4wozH-3vtrA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzb SPHINGOSINE KINASE 1

(Homo sapiens) 		PF00781
(DAGK_cat) 		4 LEU A 116
ASP A  81
TYR A 123
LEU A 120
 None
None
EDO  A 408 (-4.8A)
EDO  A 403 (-4.5A)
 1.27A 4wozF-3vzbA:
undetectable
4wozH-3vzbA:
undetectable		 4wozF-3vzbA:
21.64
4wozH-3vzbA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 130
ASP A 202
TYR A 148
LEU A 161
 None
 1.20A 4wozF-3w18A:
undetectable
4wozH-3w18A:
undetectable		 4wozF-3w18A:
20.87
4wozH-3w18A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnb PROTEIN TRANSLATION
ELONGATION FACTOR 1A

(Methanosarcina
mazei) 		no annotation 4 LEU A  89
ASP A  88
LEU A 333
THR A 268
 None
 1.06A 4wozF-3wnbA:
undetectable
4wozH-3wnbA:
1.9		 4wozF-3wnbA:
23.21
4wozH-3wnbA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrt BETA-LACTAMASE

(Chromohalobacter
sp. 560) 		PF00144
(Beta-lactamase) 		4 LEU A  13
ASP A  14
LEU A 361
THR A  40
 None
 1.16A 4wozF-3wrtA:
undetectable
4wozH-3wrtA:
undetectable		 4wozF-3wrtA:
22.31
4wozH-3wrtA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A2059
ASP A2062
TYR A2037
LEU A2034
 None
 1.25A 4wozF-3zbfA:
undetectable
4wozH-3zbfA:
undetectable		 4wozF-3zbfA:
22.19
4wozH-3zbfA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aj9 CATALASE-3

(Neurospora
crassa) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 LEU A 382
ASP A 379
TYR A 389
LEU A 386
 None
None
HEM  A1715 (-3.7A)
None
 1.03A 4wozF-4aj9A:
undetectable
4wozH-4aj9A:
undetectable		 4wozF-4aj9A:
19.58
4wozH-4aj9A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bom ENVELOPE
GLYCOPROTEIN B

(Human
alphaherpesvirus
1) 		PF00606
(Glycoprotein_B)
PF17416
(Glycoprot_B_PH1)
PF17417
(Glycoprot_B_PH2) 		4 LEU A 330
ASP A 329
TYR A 164
THR A 162
 None
 1.20A 4wozF-4bomA:
undetectable
4wozH-4bomA:
undetectable		 4wozF-4bomA:
17.86
4wozH-4bomA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ev1 ANABENA TIC22

(Anabaena sp.) 		PF04278
(Tic22) 		4 LEU A 217
ASP A 218
LEU A 191
THR A 225
 NHE  A 302 (-3.8A)
None
NHE  A 302 (-4.5A)
NHE  A 302 (-3.1A)
 1.24A 4wozF-4ev1A:
undetectable
4wozH-4ev1A:
undetectable		 4wozF-4ev1A:
23.32
4wozH-4ev1A:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgm AMINOPEPTIDASE N
FAMILY PROTEIN

(Idiomarina
loihiensis) 		PF05299
(Peptidase_M61)
PF13180
(PDZ_2) 		4 LEU A 391
ASP A 388
TYR A 431
LEU A 428
 None
 1.27A 4wozF-4fgmA:
undetectable
4wozH-4fgmA:
undetectable		 4wozF-4fgmA:
18.74
4wozH-4fgmA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgu LEGUMAIN

(Homo sapiens) 		PF01650
(Peptidase_C13) 		4 LEU A 339
ASP A 340
LEU A 312
THR A 332
 None
 1.03A 4wozF-4fguA:
undetectable
4wozH-4fguA:
1.7		 4wozF-4fguA:
19.50
4wozH-4fguA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsu LYSINE-SPECIFIC
HISTONE DEMETHYLASE
1B
PUTATIVE
OXIDOREDUCTASE GLYR1

(Homo sapiens;
Homo sapiens) 		PF01593
(Amino_oxidase)
PF04433
(SWIRM)
PF07496
(zf-CW)
no annotation 		4 LEU B 221
TYR A 809
LEU A 810
THR A 364
 None
 1.26A 4wozF-4hsuB:
undetectable
4wozH-4hsuB:
undetectable		 4wozF-4hsuB:
16.45
4wozH-4hsuB:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iss ALLOPHANATE
HYDROLASE

(Kluyveromyces
lactis) 		PF01425
(Amidase) 		4 LEU A 443
ASP A 442
LEU A 430
THR A 285
 None
 1.27A 4wozF-4issA:
undetectable
4wozH-4issA:
undetectable		 4wozF-4issA:
19.53
4wozH-4issA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv9 TRYPTOPHAN
2-MONOOXYGENASE

(Pseudomonas
savastanoi) 		PF01593
(Amino_oxidase) 		4 LEU A 435
ASP A 438
LEU A 411
THR A 414
 None
 1.02A 4wozF-4iv9A:
undetectable
4wozH-4iv9A:
undetectable		 4wozF-4iv9A:
20.57
4wozH-4iv9A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lcm TRANSESTERASE

(Aspergillus
terreus) 		PF00144
(Beta-lactamase) 		4 LEU A  97
ASP A  98
LEU A 301
THR A 139
 None
 1.24A 4wozF-4lcmA:
undetectable
4wozH-4lcmA:
undetectable		 4wozF-4lcmA:
21.34
4wozH-4lcmA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx8 PERIPLASMIC BINDING
PROTEIN

(Xylanimonas
cellulosilytica) 		PF01497
(Peripla_BP_2) 		4 LEU A 129
ASP A  51
LEU A 146
THR A 138
 None
 1.20A 4wozF-4mx8A:
undetectable
4wozH-4mx8A:
undetectable		 4wozF-4mx8A:
22.03
4wozH-4mx8A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6d NS1

(West Nile virus) 		PF00948
(Flavi_NS1) 		4 LEU B 198
ASP B  24
LEU B  63
THR B 165
 None
 1.26A 4wozF-4o6dB:
undetectable
4wozH-4o6dB:
undetectable		 4wozF-4o6dB:
24.30
4wozH-4o6dB:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Homo sapiens;
Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 LEU A 354
TYR A 285
LEU A 288
THR A 280
 None
 1.11A 4wozF-4pd3A:
undetectable
4wozH-4pd3A:
undetectable		 4wozF-4pd3A:
15.87
4wozH-4pd3A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9i SERPIN-18

(Bombyx mori) 		PF00079
(Serpin) 		4 LEU A 378
ASP A 379
LEU A 283
THR A  36
 None
 1.25A 4wozF-4r9iA:
undetectable
4wozH-4r9iA:
undetectable		 4wozF-4r9iA:
23.82
4wozH-4r9iA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uxe LARGE TAIL FIBER
PROTEIN P34

(Escherichia
virus T4) 		no annotation 4 LEU A1134
ASP A1133
LEU A1191
THR A1143
 None
 1.14A 4wozF-4uxeA:
undetectable
4wozH-4uxeA:
undetectable		 4wozF-4uxeA:
20.33
4wozH-4uxeA:
20.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4woq N-ACETYLNEURAMINATE
LYASE

(Clostridioides
difficile) 		PF00701
(DHDPS) 		4 LEU A 159
ASP A 160
TYR A 182
LEU A 183
 2KT  A 401 ( 4.4A)
None
2KT  A 401 (-3.8A)
2KT  A 401 ( 4.0A)
 0.11A 4wozF-4woqA:
51.9
4wozH-4woqA:
52.5		 4wozF-4woqA:
100.00
4wozH-4woqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeq TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Desulfovibrio
vulgaris) 		PF03480
(DctP) 		4 LEU A 116
ASP A 117
LEU A 140
THR A 248
 None
 1.05A 4wozF-4xeqA:
undetectable
4wozH-4xeqA:
undetectable		 4wozF-4xeqA:
21.61
4wozH-4xeqA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus AP22) 		no annotation 4 LEU A 149
ASP A 150
LEU A 179
THR A 206
 None
EDO  A 807 ( 3.6A)
None
None
 0.75A 4wozF-4y9vA:
undetectable
4wozH-4y9vA:
undetectable		 4wozF-4y9vA:
18.28
4wozH-4y9vA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cmc ML032222A IGLUR

(Mnemiopsis
leidyi) 		PF10613
(Lig_chan-Glu_bd) 		4 LEU A 131
ASP A 132
TYR A 158
LEU A 161
 None
 1.18A 4wozF-5cmcA:
undetectable
4wozH-5cmcA:
undetectable		 4wozF-5cmcA:
20.06
4wozH-5cmcA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5du2 ESPG2
GLYCOSYLTRANSFERASE

(Actinomadura
verrucosospora) 		PF00201
(UDPGT) 		4 LEU A 164
ASP A 161
TYR A  82
LEU A  83
 None
 1.25A 4wozF-5du2A:
undetectable
4wozH-5du2A:
undetectable		 4wozF-5du2A:
22.09
4wozH-5du2A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Cryptococcus
neoformans) 		PF02358
(Trehalose_PPase) 		4 LEU A 157
ASP A 158
TYR A 141
LEU A 179
 BME  A 403 ( 3.5A)
None
BME  A 403 (-3.4A)
BME  A 403 ( 4.3A)
 1.27A 4wozF-5dx9A:
undetectable
4wozH-5dx9A:
undetectable		 4wozF-5dx9A:
22.83
4wozH-5dx9A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs7 CHOLOYLGLYCINE
HYDROLASE

(Enterococcus
faecalis) 		PF02275
(CBAH) 		4 ASP A  60
TYR A  64
LEU A  63
THR A  31
 None
 0.89A 4wozF-5gs7A:
undetectable
4wozH-5gs7A:
undetectable		 4wozF-5gs7A:
21.86
4wozH-5gs7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hke BILE SALT HYDROLASE

(Lactobacillus
salivarius) 		PF02275
(CBAH) 		4 ASP A  60
TYR A  64
LEU A  63
THR A  31
 None
 0.87A 4wozF-5hkeA:
undetectable
4wozH-5hkeA:
undetectable		 4wozF-5hkeA:
24.51
4wozH-5hkeA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8i UREA AMIDOLYASE

(Kluyveromyces
lactis) 		PF00289
(Biotin_carb_N)
PF01425
(Amidase)
PF02626
(CT_A_B)
PF02682
(CT_C_D)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LEU A 443
ASP A 442
LEU A 430
THR A 285
 None
 1.28A 4wozF-5i8iA:
undetectable
4wozH-5i8iA:
undetectable		 4wozF-5i8iA:
9.90
4wozH-5i8iA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idv LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA

(Acinetobacter
baumannii) 		PF00005
(ABC_tran) 		4 LEU A 200
ASP A 201
LEU A 198
THR A 237
 None
None
EDO  A 302 ( 4.4A)
None
 1.19A 4wozF-5idvA:
undetectable
4wozH-5idvA:
undetectable		 4wozF-5idvA:
22.82
4wozH-5idvA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iki CYTOCHROME P450(MEG)

(Bacillus
megaterium) 		PF00067
(p450) 		4 LEU A 294
ASP A 295
LEU A  56
THR A  89
 HEM  A 501 (-4.2A)
None
None
HEM  A 501 (-4.1A)
 1.13A 4wozF-5ikiA:
undetectable
4wozH-5ikiA:
undetectable		 4wozF-5ikiA:
22.57
4wozH-5ikiA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE

(Bacillus
anthracis) 		PF04127
(DFP) 		4 LEU A 307
ASP A 305
LEU A 319
THR A 193
 None
 1.24A 4wozF-5intA:
2.8
4wozH-5intA:
2.9		 4wozF-5intA:
21.41
4wozH-5intA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kp7 CURD

(Moorea
producens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 LEU A 406
ASP A  50
TYR A 388
LEU A 386
 None
 1.23A 4wozF-5kp7A:
undetectable
4wozH-5kp7A:
undetectable		 4wozF-5kp7A:
22.17
4wozH-5kp7A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lon KLLA0E01827P

(Kluyveromyces
lactis) 		PF06058
(DCP1) 		4 LEU B  29
TYR B 177
LEU B 174
THR B 184
 None
 1.26A 4wozF-5lonB:
undetectable
4wozH-5lonB:
undetectable		 4wozF-5lonB:
22.07
4wozH-5lonB:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN

(Homo sapiens) 		PF00023
(Ank)
PF00225
(Kinesin)
PF12796
(Ank_2) 		4 LEU C 657
ASP C 686
LEU C 628
THR C 665
 None
 1.19A 4wozF-5mioC:
undetectable
4wozH-5mioC:
undetectable		 4wozF-5mioC:
18.36
4wozH-5mioC:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpt CITRININ POLYKETIDE
SYNTHASE

(Monascus
purpureus) 		PF08242
(Methyltransf_12) 		4 ASP A2019
TYR A2015
LEU A1989
THR A1999
 SAH  A2201 (-2.0A)
None
None
None
 1.24A 4wozF-5mptA:
undetectable
4wozH-5mptA:
undetectable		 4wozF-5mptA:
21.78
4wozH-5mptA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n94 CG9323, ISOFORM A

(Drosophila
melanogaster) 		no annotation 4 LEU A 392
ASP A 393
TYR A 379
LEU A 380
 None
 1.26A 4wozF-5n94A:
undetectable
4wozH-5n94A:
undetectable		 4wozF-5n94A:
undetectable
4wozH-5n94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5net O1 MANISA VP3

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		4 LEU 3  45
ASP 3  46
TYR 3  98
LEU 3  94
 None
 1.21A 4wozF-5net3:
undetectable
4wozH-5net3:
undetectable		 4wozF-5net3:
21.40
4wozH-5net3:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxf LONG-TAIL FIBER
PROXIMAL SUBUNIT

(Escherichia
virus T4) 		no annotation 4 LEU A1134
ASP A1133
LEU A1191
THR A1143
 None
 1.15A 4wozF-5nxfA:
undetectable
4wozH-5nxfA:
undetectable		 4wozF-5nxfA:
19.73
4wozH-5nxfA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oj2 MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1

(Gallus gallus) 		PF13927
(Ig_3) 		4 LEU A 201
ASP A 208
LEU A 155
THR A 175
 None
 1.23A 4wozF-5oj2A:
undetectable
4wozH-5oj2A:
undetectable		 4wozF-5oj2A:
17.47
4wozH-5oj2A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuj ANCESTRAL PROTEIN
CDT-ANC1

(unidentified) 		no annotation 4 LEU C  52
ASP C  49
TYR C 237
LEU C 240
 None
 1.27A 4wozF-5tujC:
undetectable
4wozH-5tujC:
undetectable		 4wozF-5tujC:
undetectable
4wozH-5tujC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrp PYRUVATE KINASE

(Mycobacterium
tuberculosis) 		no annotation 4 ASP A 120
TYR A 109
LEU A 112
THR A 165
 None
 1.19A 4wozF-5wrpA:
7.7
4wozH-5wrpA:
13.3		 4wozF-5wrpA:
21.11
4wozH-5wrpA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yem CATALASE

(Mycothermus
thermophilus) 		no annotation 4 LEU A 362
ASP A 359
TYR A 369
LEU A 366
 None
None
HEM  A 704 (-3.8A)
None
 1.03A 4wozF-5yemA:
undetectable
4wozH-5yemA:
undetectable		 4wozF-5yemA:
undetectable
4wozH-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5za2 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 4 LEU A  85
ASP A  86
LEU A 253
THR A 111
 None
 1.23A 4wozF-5za2A:
undetectable
4wozH-5za2A:
undetectable		 4wozF-5za2A:
undetectable
4wozH-5za2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt CORE PROTEIN VP6

(Aquareovirus C) 		no annotation 4 LEU U 211
TYR U 177
LEU U 174
THR U 188
 None
 1.18A 4wozF-5zvtU:
undetectable
4wozH-5zvtU:
undetectable		 4wozF-5zvtU:
undetectable
4wozH-5zvtU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bm8 ENVELOPE
GLYCOPROTEIN B

(Human
alphaherpesvirus
1) 		no annotation 4 LEU A 330
ASP A 329
TYR A 164
THR A 162
 None
 1.12A 4wozF-6bm8A:
undetectable
4wozH-6bm8A:
undetectable		 4wozF-6bm8A:
undetectable
4wozH-6bm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brm PUTATIVE
METAL-DEPENDENT
ISOTHIOCYANATE
HYDROLASE SAXA

(Pectobacterium
carotovorum) 		no annotation 4 LEU A  57
ASP A  56
LEU A  21
THR A   4
 None
 1.27A 4wozF-6brmA:
undetectable
4wozH-6brmA:
undetectable		 4wozF-6brmA:
undetectable
4wozH-6brmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6enz ACIDIC AMINO ACID
DECARBOXYLASE GADL1

(Mus musculus) 		no annotation 4 LEU A 492
ASP A 493
TYR A 399
LEU A 400
 None
 1.24A 4wozF-6enzA:
undetectable
4wozH-6enzA:
undetectable		 4wozF-6enzA:
undetectable
4wozH-6enzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Saccharomyces
cerevisiae) 		no annotation 4 LEU U  62
ASP U  63
LEU U 155
THR U  92
 None
 1.27A 4wozF-6ezmU:
undetectable
4wozH-6ezmU:
undetectable		 4wozF-6ezmU:
undetectable
4wozH-6ezmU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5o POLYMERASE ACIDIC
PROTEIN

(Influenza B
virus) 		no annotation 4 LEU A 162
ASP A 163
TYR A 154
LEU A 156
 None
 1.24A 4wozF-6f5oA:
undetectable
4wozH-6f5oA:
undetectable		 4wozF-6f5oA:
undetectable
4wozH-6f5oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gi2 FERRIC ENTEROBACTIN
ESTERASE

(Pseudomonas
aeruginosa) 		no annotation 4 LEU A 129
ASP A 130
LEU A 162
THR A 169
 None
 1.11A 4wozF-6gi2A:
undetectable
4wozH-6gi2A:
undetectable		 4wozF-6gi2A:
undetectable
4wozH-6gi2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gui -

(-) 		no annotation 4 LEU A 119
ASP A 120
LEU A 153
THR A 160
 None
 1.19A 4wozF-6guiA:
undetectable
4wozH-6guiA:
undetectable		 4wozF-6guiA:
undetectable
4wozH-6guiA:
undetectable