SIMILAR PATTERNS OF AMINO ACIDS FOR 4WOZ_B_MN9B401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a76 FLAP ENDONUCLEASE-1
PROTEIN

(Methanocaldococcus
jannaschii) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 SER A 210
LEU A 211
ASP A 212
LEU A 204
 None
 0.92A 4wozA-1a76A:
1.2
4wozB-1a76A:
1.0		 4wozA-1a76A:
21.84
4wozB-1a76A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dr6 DIHYDROFOLATE
REDUCTASE

(Gallus gallus) 		PF00186
(DHFR_1) 		4 SER A  92
LEU A  93
ASP A  94
LEU A  75
 None
None
None
NAP  A 191 (-4.3A)
 0.90A 4wozA-1dr6A:
undetectable
4wozB-1dr6A:
undetectable		 4wozA-1dr6A:
21.61
4wozB-1dr6A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY

(Escherichia
coli) 		PF01116
(F_bP_aldolase) 		4 SER A  86
LEU A  87
ASP A  88
LEU A 116
 None
 0.84A 4wozA-1gvfA:
9.0
4wozB-1gvfA:
12.0		 4wozA-1gvfA:
24.19
4wozB-1gvfA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i60 IOLI PROTEIN

(Bacillus
subtilis) 		PF01261
(AP_endonuc_2) 		4 SER A  47
LEU A  48
ASP A  49
LEU A  43
 None
 0.85A 4wozA-1i60A:
6.9
4wozB-1i60A:
6.4		 4wozA-1i60A:
23.60
4wozB-1i60A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl3 PREPROTEIN
TRANSLOCASE SECA 1
SUBUNIT

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 SER A 193
LEU A 194
ASP A 195
LEU A 663
 None
 0.93A 4wozA-1nl3A:
0.4
4wozB-1nl3A:
0.3		 4wozA-1nl3A:
16.01
4wozB-1nl3A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oki BETA CRYSTALLIN B1

(Homo sapiens) 		PF00030
(Crystall) 		4 SER A 227
LEU A 228
TYR A 176
LEU A 173
 None
 0.88A 4wozA-1okiA:
undetectable
4wozB-1okiA:
undetectable		 4wozA-1okiA:
20.59
4wozB-1okiA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rep PROTEIN (REPLICATION
INITIATION PROTEIN)

(Escherichia
coli) 		PF01051
(Rep_3) 		4 THR C 220
LEU C 224
TYR C 166
LEU C 169
 None
 0.98A 4wozA-1repC:
undetectable
4wozB-1repC:
undetectable		 4wozA-1repC:
19.81
4wozB-1repC:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb8 WBPP

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		4 SER A 306
LEU A 307
ASP A 235
LEU A 152
 UD2  A 343 (-3.4A)
None
None
None
 0.72A 4wozA-1sb8A:
2.8
4wozB-1sb8A:
2.8		 4wozA-1sb8A:
22.52
4wozB-1sb8A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u70 DIHYDROFOLATE
REDUCTASE

(Mus musculus) 		PF00186
(DHFR_1) 		4 SER A  92
LEU A  93
ASP A  94
LEU A  75
 None
None
None
NDP  A 188 (-4.2A)
 0.93A 4wozA-1u70A:
undetectable
4wozB-1u70A:
undetectable		 4wozA-1u70A:
21.47
4wozB-1u70A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u71 DIHYDROFOLATE
REDUCTASE

(Homo sapiens) 		PF00186
(DHFR_1) 		4 SER A  92
LEU A  93
ASP A  94
LEU A  75
 None
 0.90A 4wozA-1u71A:
undetectable
4wozB-1u71A:
undetectable		 4wozA-1u71A:
21.54
4wozB-1u71A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x87 UROCANASE PROTEIN

(Geobacillus
stearothermophilus) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 SER A 213
LEU A 214
ASP A 215
LEU A 235
 None
 1.04A 4wozA-1x87A:
undetectable
4wozB-1x87A:
undetectable		 4wozA-1x87A:
19.96
4wozB-1x87A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ycn PUTATIVE
CA2+-DEPENDENT
MEMBRANE-BINDING
PROTEIN ANNEXIN

(Arabidopsis
thaliana) 		PF00191
(Annexin) 		4 THR A 204
SER A 194
LEU A 193
LEU A 240
 None
 0.86A 4wozA-1ycnA:
undetectable
4wozB-1ycnA:
undetectable		 4wozA-1ycnA:
22.16
4wozB-1ycnA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ye9 CATALASE HPII

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 LEU E 408
ASP E 405
TYR E 415
LEU E 412
 None
None
HDD  E 760 (-3.8A)
None
 1.04A 4wozA-1ye9E:
undetectable
4wozB-1ye9E:
undetectable		 4wozA-1ye9E:
20.45
4wozB-1ye9E:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a14 INDOLETHYLAMINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		4 SER A 172
LEU A 173
ASP A 174
LEU A 216
 None
 0.99A 4wozA-2a14A:
undetectable
4wozB-2a14A:
undetectable		 4wozA-2a14A:
21.73
4wozB-2a14A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))

(Streptococcus
pyogenes) 		PF00390
(malic)
PF03949
(Malic_M) 		4 SER A 185
LEU A 186
ASP A 187
LEU A 179
 None
 1.02A 4wozA-2a9fA:
undetectable
4wozB-2a9fA:
undetectable		 4wozA-2a9fA:
22.64
4wozB-2a9fA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bsz ARYLAMINE
N-ACETYLTRANSFERASE
1

(Mesorhizobium
loti) 		PF00797
(Acetyltransf_2) 		4 SER A  25
LEU A  26
ASP A  27
LEU A 119
 None
 0.37A 4wozA-2bszA:
undetectable
4wozB-2bszA:
undetectable		 4wozA-2bszA:
20.86
4wozB-2bszA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5l DIPEPTIDYL
AMINOPEPTIDASE IV,
PUTATIVE

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 SER A 290
LEU A 289
TYR A 315
LEU A 298
 None
 0.78A 4wozA-2d5lA:
2.4
4wozB-2d5lA:
2.1		 4wozA-2d5lA:
18.52
4wozB-2d5lA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		4 THR A1049
LEU A1045
ASP A1042
LEU A1059
 None
 0.83A 4wozA-2ec5A:
undetectable
4wozB-2ec5A:
undetectable		 4wozA-2ec5A:
18.21
4wozB-2ec5A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2izp PUTATIVE MEMBRANE
ANTIGEN

(Burkholderia
pseudomallei) 		PF06511
(IpaD) 		4 SER A1166
ASP A1163
TYR A1171
LEU A1168
 None
 0.90A 4wozA-2izpA:
undetectable
4wozB-2izpA:
undetectable		 4wozA-2izpA:
24.78
4wozB-2izpA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nw0 PLYB

(unidentified
phage) 		PF01183
(Glyco_hydro_25) 		4 SER A 180
LEU A 181
ASP A 182
LEU A 175
 None
 0.64A 4wozA-2nw0A:
8.5
4wozB-2nw0A:
8.6		 4wozA-2nw0A:
18.24
4wozB-2nw0A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pop MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 1

(Homo sapiens) 		PF00481
(PP2C) 		4 SER A 322
LEU A 323
ASP A 324
LEU A 369
 None
 0.94A 4wozA-2popA:
undetectable
4wozB-2popA:
undetectable		 4wozA-2popA:
21.89
4wozB-2popA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxl HEAT SHOCK PROTEIN
HOMOLOG SSE1

(Saccharomyces
cerevisiae) 		PF00012
(HSP70) 		4 THR A 349
SER A 302
LEU A 306
LEU A 278
 None
 0.88A 4wozA-2qxlA:
undetectable
4wozB-2qxlA:
undetectable		 4wozA-2qxlA:
18.89
4wozB-2qxlA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qxt LIPASE

(Bacillus
subtilis) 		PF01674
(Lipase_2) 		4 THR A  66
SER A  32
TYR A  37
LEU A  36
 None
 1.05A 4wozA-2qxtA:
1.5
4wozB-2qxtA:
1.4		 4wozA-2qxtA:
22.41
4wozB-2qxtA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5v PCZA361.1

(Amycolatopsis
orientalis) 		PF00903
(Glyoxalase)
PF14696
(Glyoxalase_5) 		4 SER A 284
LEU A 285
ASP A 286
LEU A 280
 None
 0.82A 4wozA-2r5vA:
undetectable
4wozB-2r5vA:
undetectable		 4wozA-2r5vA:
22.19
4wozB-2r5vA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr5 GLYCOGEN OPERON
PROTEIN GLGX

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 THR A 353
SER A 392
LEU A 391
ASP A 388
 None
 1.04A 4wozA-2vr5A:
3.6
4wozB-2vr5A:
3.6		 4wozA-2vr5A:
18.45
4wozB-2vr5A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		4 THR A 898
SER A 947
TYR A 862
LEU A 933
 None
 1.05A 4wozA-2vz9A:
undetectable
4wozB-2vz9A:
undetectable		 4wozA-2vz9A:
8.54
4wozB-2vz9A:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w40 GLYCEROL KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 SER A 459
LEU A 460
ASP A 461
LEU A 452
 None
 0.70A 4wozA-2w40A:
undetectable
4wozB-2w40A:
undetectable		 4wozA-2w40A:
22.39
4wozB-2w40A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5o ALPHA-L-ARABINOFURAN
OSIDASE

(Fusarium
graminearum) 		no annotation 4 THR A 133
LEU A 130
ASP A 129
LEU A 160
 None
 1.04A 4wozA-2w5oA:
undetectable
4wozB-2w5oA:
undetectable		 4wozA-2w5oA:
21.90
4wozB-2w5oA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 LEU A 344
ASP A 341
TYR A 351
LEU A 348
 None
None
HDD  A 690 (-3.7A)
None
 0.94A 4wozA-2xf2A:
undetectable
4wozB-2xf2A:
undetectable		 4wozA-2xf2A:
17.91
4wozB-2xf2A:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8c DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE

(Plasmodium
falciparum) 		PF00692
(dUTPase) 		4 THR A  97
LEU A 120
TYR A 128
LEU A  39
 None
 1.05A 4wozA-2y8cA:
undetectable
4wozB-2y8cA:
undetectable		 4wozA-2y8cA:
22.90
4wozB-2y8cA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1j CELL CYCLE
CHECKPOINT PROTEIN
RAD1

(Homo sapiens) 		PF02144
(Rad1) 		4 SER C 191
LEU C 190
TYR C 223
LEU C 177
 None
 0.92A 4wozA-3a1jC:
undetectable
4wozB-3a1jC:
undetectable		 4wozA-3a1jC:
22.22
4wozB-3a1jC:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		4 SER A 473
ASP A 472
TYR A 493
LEU A 494
 None
 1.01A 4wozA-3aibA:
3.6
4wozB-3aibA:
undetectable		 4wozA-3aibA:
17.59
4wozB-3aibA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cir FUMARATE REDUCTASE
IRON-SULFUR SUBUNIT

(Escherichia
coli) 		PF13085
(Fer2_3)
PF13183
(Fer4_8) 		4 SER B  35
LEU B  36
TYR B  84
LEU B  81
 None
 0.77A 4wozA-3cirB:
undetectable
4wozB-3cirB:
undetectable		 4wozA-3cirB:
24.06
4wozB-3cirB:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e38 TWO-DOMAIN PROTEIN
CONTAINING PREDICTED
PHP-LIKE
METAL-DEPENDENT
PHOSPHOESTERASE

(Bacteroides
vulgatus) 		PF16392
(DUF5001) 		4 LEU A 269
ASP A 268
TYR A  36
LEU A  33
 None
 1.05A 4wozA-3e38A:
4.2
4wozB-3e38A:
3.1		 4wozA-3e38A:
22.22
4wozB-3e38A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efe THIJ/PFPI FAMILY
PROTEIN

(Bacillus
anthracis) 		PF01965
(DJ-1_PfpI) 		4 SER A  64
LEU A  65
ASP A  66
TYR A   9
 None
 1.03A 4wozA-3efeA:
undetectable
4wozB-3efeA:
undetectable		 4wozA-3efeA:
24.83
4wozB-3efeA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezi NITRATE/NITRITE
SENSOR PROTEIN NARX

(Escherichia
coli) 		PF13675
(PilJ) 		4 LEU A 134
ASP A 135
TYR A 105
LEU A 102
 None
None
IPA  A   1 ( 4.2A)
IPA  A   1 ( 4.8A)
 1.03A 4wozA-3eziA:
undetectable
4wozB-3eziA:
undetectable		 4wozA-3eziA:
20.34
4wozB-3eziA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fef PUTATIVE GLUCOSIDASE
LPLD,
ALPHA-GALACTURONIDAS
E

(Bacillus
subtilis) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 SER A  91
LEU A  92
ASP A  93
LEU A  88
 None
 0.98A 4wozA-3fefA:
undetectable
4wozB-3fefA:
undetectable		 4wozA-3fefA:
22.75
4wozB-3fefA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h04 UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF07859
(Abhydrolase_3) 		4 SER A  74
LEU A  75
ASP A  76
LEU A  70
 None
 0.91A 4wozA-3h04A:
undetectable
4wozB-3h04A:
undetectable		 4wozA-3h04A:
24.77
4wozB-3h04A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hj6 FRUCTOKINASE

(Halothermothrix
orenii) 		PF00294
(PfkB) 		4 SER A 212
LEU A 213
ASP A 214
LEU A 242
 None
 0.91A 4wozA-3hj6A:
undetectable
4wozB-3hj6A:
undetectable		 4wozA-3hj6A:
24.59
4wozB-3hj6A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icx PRE MRNA SPLICING
PROTEIN

(Sulfolobus
solfataricus) 		PF01798
(Nop) 		4 SER A 283
LEU A 284
ASP A 285
LEU A 278
 None
 0.96A 4wozA-3icxA:
undetectable
4wozB-3icxA:
undetectable		 4wozA-3icxA:
23.36
4wozB-3icxA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA

(Homo sapiens) 		PF00041
(fn3)
PF06328
(Lep_receptor_Ig)
PF09240
(IL6Ra-bind) 		4 THR A 544
SER A 558
LEU A 557
LEU A 560
 None
 1.03A 4wozA-3l5hA:
undetectable
4wozB-3l5hA:
undetectable		 4wozA-3l5hA:
20.34
4wozB-3l5hA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lst CALO1
METHYLTRANSFERASE

(Micromonospora
echinospora) 		PF00891
(Methyltransf_2) 		4 THR A 307
SER A 143
LEU A 144
ASP A 145
 None
 1.01A 4wozA-3lstA:
undetectable
4wozB-3lstA:
undetectable		 4wozA-3lstA:
22.13
4wozB-3lstA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq0 TRANSCRIPTIONAL
REPRESSOR OF THE
BLCABC OPERON

(Agrobacterium
tumefaciens) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		4 SER A 166
LEU A 168
ASP A 167
LEU A 173
 None
 1.02A 4wozA-3mq0A:
undetectable
4wozB-3mq0A:
undetectable		 4wozA-3mq0A:
21.91
4wozB-3mq0A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfw FLAVIN
REDUCTASE-LIKE,
FMN-BINDING PROTEIN

(Mycolicibacterium
thermoresistibile) 		PF01613
(Flavin_Reduct) 		4 SER A  45
LEU A  46
ASP A  47
LEU A 179
 None
 0.96A 4wozA-3nfwA:
undetectable
4wozB-3nfwA:
undetectable		 4wozA-3nfwA:
18.21
4wozB-3nfwA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrv PUTATIVE
TRANSCRIPTIONAL
REGULATOR (MARR/EMRR
FAMILY)

(Acinetobacter
sp. ADP1) 		PF12802
(MarR_2) 		5 THR A  71
SER A  58
LEU A  63
ASP A  64
LEU A  61
 None
 1.33A 4wozA-3nrvA:
undetectable
4wozB-3nrvA:
undetectable		 4wozA-3nrvA:
23.10
4wozB-3nrvA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nxl GLUCARATE
DEHYDRATASE

(Burkholderia
lata) 		PF13378
(MR_MLE_C) 		4 SER A 261
LEU A 262
ASP A 263
TYR A 289
 None
 0.97A 4wozA-3nxlA:
6.6
4wozB-3nxlA:
11.8		 4wozA-3nxlA:
21.51
4wozB-3nxlA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oml PEROXISOMAL
MULTIFUNCTIONAL
ENZYME TYPE 2,
CG3415

(Drosophila
melanogaster) 		PF00106
(adh_short)
PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		4 SER A 263
LEU A 264
ASP A 265
LEU A 306
 None
 0.79A 4wozA-3omlA:
undetectable
4wozB-3omlA:
undetectable		 4wozA-3omlA:
20.45
4wozB-3omlA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Actinobacillus
succinogenes) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 SER A 242
LEU A 243
ASP A 244
TYR A 270
 None
 0.98A 4wozA-3pfrA:
7.5
4wozB-3pfrA:
11.9		 4wozA-3pfrA:
19.56
4wozB-3pfrA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qcw NEUREXIN-1-ALPHA

(Bos taurus) 		PF00008
(EGF)
PF02210
(Laminin_G_2) 		4 THR A 408
SER A 303
LEU A 415
ASP A 306
 None
 1.05A 4wozA-3qcwA:
undetectable
4wozB-3qcwA:
undetectable		 4wozA-3qcwA:
14.22
4wozB-3qcwA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrl SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
B

(Helicobacter
pylori) 		PF01144
(CoA_trans) 		4 SER B 191
LEU B 192
ASP B 193
LEU B 186
 None
 0.81A 4wozA-3rrlB:
undetectable
4wozB-3rrlB:
undetectable		 4wozA-3rrlB:
23.55
4wozB-3rrlB:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sag EXOSOME COMPONENT 10

(Homo sapiens) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		4 SER A 293
LEU A 294
ASP A 295
LEU A 345
 SER  A 293 ( 0.0A)
LEU  A 294 ( 0.6A)
ASP  A 295 ( 0.6A)
LEU  A 345 ( 0.6A)
 0.86A 4wozA-3sagA:
undetectable
4wozB-3sagA:
undetectable		 4wozA-3sagA:
21.20
4wozB-3sagA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdu DCN1-LIKE PROTEIN 1

(Homo sapiens) 		PF03556
(Cullin_binding) 		4 SER A  99
ASP A  96
TYR A 181
LEU A 184
 None
 1.04A 4wozA-3tduA:
undetectable
4wozB-3tduA:
undetectable		 4wozA-3tduA:
21.52
4wozB-3tduA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttb EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
paradoxus) 		PF02335
(Cytochrom_C552) 		4 THR A  61
LEU A 194
ASP A 195
TYR A 228
 SO4  A 533 (-3.8A)
HEC  A1001 ( 3.7A)
None
HEC  A1002 (-3.6A)
 1.02A 4wozA-3ttbA:
undetectable
4wozB-3ttbA:
undetectable		 4wozA-3ttbA:
20.04
4wozB-3ttbA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttb EIGHT-HEME NITRITE
REDUCTASE

(Thioalkalivibrio
paradoxus) 		PF02335
(Cytochrom_C552) 		4 THR A  61
LEU A 221
ASP A 220
LEU A 123
 SO4  A 533 (-3.8A)
None
None
None
 0.95A 4wozA-3ttbA:
undetectable
4wozB-3ttbA:
undetectable		 4wozA-3ttbA:
20.04
4wozB-3ttbA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue6 AUREOCHROME1

(Vaucheria
frigida) 		PF13426
(PAS_9) 		4 SER A 245
LEU A 246
ASP A 247
LEU A 239
 None
 0.73A 4wozA-3ue6A:
undetectable
4wozB-3ue6A:
undetectable		 4wozA-3ue6A:
20.13
4wozB-3ue6A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up9 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Actinomyces
odontolyticus) 		PF03180
(Lipoprotein_9) 		4 SER A 131
LEU A 132
ASP A 133
LEU A 222
 None
None
PG4  A 303 (-4.6A)
None
 0.99A 4wozA-3up9A:
undetectable
4wozB-3up9A:
undetectable		 4wozA-3up9A:
23.27
4wozB-3up9A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voc BETA/ALPHA-AMYLASE

(Paenibacillus
polymyxa) 		PF01373
(Glyco_hydro_14) 		4 SER A 204
LEU A 205
ASP A 206
LEU A 219
 None
GOL  A 506 (-4.6A)
GOL  A 506 (-2.9A)
None
 0.78A 4wozA-3vocA:
11.1
4wozB-3vocA:
10.6		 4wozA-3vocA:
24.52
4wozB-3vocA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wnb PROTEIN TRANSLATION
ELONGATION FACTOR 1A

(Methanosarcina
mazei) 		no annotation 4 THR A 268
LEU A  89
ASP A  88
LEU A 333
 None
 1.05A 4wozA-3wnbA:
undetectable
4wozB-3wnbA:
undetectable		 4wozA-3wnbA:
23.21
4wozB-3wnbA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aj9 CATALASE-3

(Neurospora
crassa) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 LEU A 382
ASP A 379
TYR A 389
LEU A 386
 None
None
HEM  A1715 (-3.7A)
None
 0.98A 4wozA-4aj9A:
undetectable
4wozB-4aj9A:
undetectable		 4wozA-4aj9A:
19.58
4wozB-4aj9A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayz HEME-BINDING PROTEIN
2

(Homo sapiens) 		PF04832
(SOUL) 		4 SER A 108
LEU A 109
TYR A  72
LEU A  69
 None
 1.02A 4wozA-4ayzA:
undetectable
4wozB-4ayzA:
undetectable		 4wozA-4ayzA:
21.85
4wozB-4ayzA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3g DNA-BINDING PROTEIN
SMUBP-2

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12) 		4 SER A 279
LEU A 280
ASP A 281
LEU A 263
 None
 0.78A 4wozA-4b3gA:
undetectable
4wozB-4b3gA:
undetectable		 4wozA-4b3gA:
18.74
4wozB-4b3gA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvm UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D- ALANINE LIGASE

(Pseudomonas
aeruginosa) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 SER A 246
LEU A 247
ASP A 248
LEU A 294
 None
 0.94A 4wozA-4cvmA:
undetectable
4wozB-4cvmA:
undetectable		 4wozA-4cvmA:
20.21
4wozB-4cvmA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2l FERRIC ENTEROBACTIN
(ENTEROCHELIN)
TRANSPORT

(Escherichia
coli) 		no annotation 4 SER A 175
LEU A 174
TYR A 191
LEU A 188
 None
 0.93A 4wozA-4e2lA:
undetectable
4wozB-4e2lA:
undetectable		 4wozA-4e2lA:
21.18
4wozB-4e2lA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		4 SER A 139
LEU A 140
ASP A 141
LEU A 128
 None
 0.98A 4wozA-4eq9A:
undetectable
4wozB-4eq9A:
undetectable		 4wozA-4eq9A:
21.94
4wozB-4eq9A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgu LEGUMAIN

(Homo sapiens) 		PF01650
(Peptidase_C13) 		4 THR A 332
LEU A 339
ASP A 340
LEU A 312
 None
 1.02A 4wozA-4fguA:
undetectable
4wozB-4fguA:
undetectable		 4wozA-4fguA:
19.50
4wozB-4fguA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8z DIHYDROFOLATE
REDUCTASE

(Pneumocystis
jirovecii) 		PF00186
(DHFR_1) 		4 SER X  97
LEU X  98
ASP X  99
LEU X 128
 None
None
None
NDP  X 302 (-4.0A)
 0.96A 4wozA-4g8zX:
undetectable
4wozB-4g8zX:
undetectable		 4wozA-4g8zX:
19.27
4wozB-4g8zX:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkh AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB

(Acinetobacter
baumannii) 		PF01636
(APH) 		4 SER A 200
LEU A 201
ASP A 202
LEU A 232
 KAN  A 301 ( 4.8A)
None
ACT  A 305 (-4.6A)
None
 1.02A 4wozA-4gkhA:
undetectable
4wozB-4gkhA:
undetectable		 4wozA-4gkhA:
20.38
4wozB-4gkhA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hn8 D-GLUCARATE
DEHYDRATASE

(Pseudomonas
mendocina) 		PF13378
(MR_MLE_C) 		4 SER A 258
LEU A 259
ASP A 260
TYR A 286
 None
 0.91A 4wozA-4hn8A:
11.8
4wozB-4hn8A:
11.8		 4wozA-4hn8A:
22.54
4wozB-4hn8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4if2 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN

(Mycobacterium
tuberculosis) 		PF02126
(PTE) 		4 THR A 179
SER A 225
LEU A 220
LEU A 227
 None
 0.89A 4wozA-4if2A:
4.1
4wozB-4if2A:
4.0		 4wozA-4if2A:
22.28
4wozB-4if2A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4in9 KARILYSIN PROTEASE

(Tannerella
forsythia) 		PF00413
(Peptidase_M10) 		4 SER A 141
LEU A 149
ASP A 148
LEU A  58
 None
 0.95A 4wozA-4in9A:
undetectable
4wozB-4in9A:
undetectable		 4wozA-4in9A:
18.75
4wozB-4in9A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv9 TRYPTOPHAN
2-MONOOXYGENASE

(Pseudomonas
savastanoi) 		PF01593
(Amino_oxidase) 		4 THR A 414
LEU A 435
ASP A 438
LEU A 411
 None
 1.02A 4wozA-4iv9A:
undetectable
4wozB-4iv9A:
undetectable		 4wozA-4iv9A:
20.57
4wozB-4iv9A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Oncorhynchus
mykiss) 		PF00079
(Serpin) 		4 THR A 155
SER A 147
LEU A 146
LEU A 127
 None
 0.82A 4wozA-4kdsA:
undetectable
4wozB-4kdsA:
undetectable		 4wozA-4kdsA:
22.84
4wozB-4kdsA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		4 SER A 167
LEU A 168
ASP A 169
LEU A 246
 None
 0.58A 4wozA-4llsA:
undetectable
4wozB-4llsA:
undetectable		 4wozA-4llsA:
21.97
4wozB-4llsA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nim VERSICOLORIN
REDUCTASE

(Brucella
melitensis) 		PF13561
(adh_short_C2) 		4 THR A  23
SER A 185
LEU A 186
LEU A 236
 None
 1.00A 4wozA-4nimA:
undetectable
4wozB-4nimA:
2.4		 4wozA-4nimA:
20.29
4wozB-4nimA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv7 ARYLAMINE
N-ACETYLTRANSFERASE

(Mesorhizobium
japonicum) 		PF00797
(Acetyltransf_2) 		4 SER A  25
LEU A  26
ASP A  27
LEU A 119
 None
 0.44A 4wozA-4nv7A:
undetectable
4wozB-4nv7A:
undetectable		 4wozA-4nv7A:
22.87
4wozB-4nv7A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe6 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00171
(Aldedh) 		4 SER A 550
LEU A 549
TYR A 181
LEU A 180
 None
 1.04A 4wozA-4oe6A:
undetectable
4wozB-4oe6A:
undetectable		 4wozA-4oe6A:
20.63
4wozB-4oe6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvo PHENYLACETATE-COENZY
ME A LIGASE

(Bacteroides
thetaiotaomicron) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		4 SER A  55
LEU A  56
ASP A  57
LEU A  23
 None
 0.88A 4wozA-4rvoA:
undetectable
4wozB-4rvoA:
undetectable		 4wozA-4rvoA:
22.49
4wozB-4rvoA:
22.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4woq N-ACETYLNEURAMINATE
LYASE

(Clostridioides
difficile) 		PF00701
(DHDPS) 		5 SER A 158
LEU A 159
ASP A 160
TYR A 182
LEU A 183
 None
2KT  A 401 ( 4.4A)
None
2KT  A 401 (-3.8A)
2KT  A 401 ( 4.0A)
 0.16A 4wozA-4woqA:
51.6
4wozB-4woqA:
52.0		 4wozA-4woqA:
100.00
4wozB-4woqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020

(Homo sapiens) 		PF08144
(CPL) 		4 SER A 517
LEU A 446
ASP A 513
LEU A 483
 None
 0.98A 4wozA-4wzwA:
undetectable
4wozB-4wzwA:
undetectable		 4wozA-4wzwA:
22.81
4wozB-4wzwA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		4 SER A 362
LEU A 363
ASP A 364
LEU A 319
 None
 1.01A 4wozA-4y23A:
undetectable
4wozB-4y23A:
undetectable		 4wozA-4y23A:
20.61
4wozB-4y23A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9v PARTICLE-ASSOCIATED
LYASE

(Acinetobacter
virus AP22) 		no annotation 4 THR A 206
LEU A 149
ASP A 150
LEU A 179
 None
None
EDO  A 807 ( 3.6A)
None
 0.74A 4wozA-4y9vA:
undetectable
4wozB-4y9vA:
undetectable		 4wozA-4y9vA:
18.28
4wozB-4y9vA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywe PUTATIVE ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 THR A 203
SER A 181
LEU A 180
ASP A  91
 None
None
None
CA  A 503 (-3.4A)
 1.02A 4wozA-4yweA:
undetectable
4wozB-4yweA:
undetectable		 4wozA-4yweA:
18.66
4wozB-4yweA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8b PTAUREO1A LOV2
DOMAIN

(Phaeodactylum
tricornutum) 		PF13426
(PAS_9) 		4 SER A 278
LEU A 279
ASP A 280
LEU A 272
 None
 0.74A 4wozA-5a8bA:
undetectable
4wozB-5a8bA:
undetectable		 4wozA-5a8bA:
20.40
4wozB-5a8bA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3k UNCHARACTERIZED
PROTEIN PA3435

(Pseudomonas
aeruginosa) 		PF00258
(Flavodoxin_1) 		4 SER A  39
LEU A  40
ASP A  41
LEU A  70
 None
 0.75A 4wozA-5b3kA:
undetectable
4wozB-5b3kA:
undetectable		 4wozA-5b3kA:
19.41
4wozB-5b3kA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5byk SULFOTRANSFERASE

(Schistosoma
mansoni) 		no annotation 4 SER A 245
LEU A 246
ASP A 247
LEU A 240
 None
 1.01A 4wozA-5bykA:
undetectable
4wozB-5bykA:
undetectable		 4wozA-5bykA:
24.84
4wozB-5bykA:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkk LOV DOMAIN

(Phaeodactylum
tricornutum) 		PF13426
(PAS_9) 		4 SER A 278
LEU A 279
ASP A 280
LEU A 272
 None
 0.85A 4wozA-5dkkA:
undetectable
4wozB-5dkkA:
undetectable		 4wozA-5dkkA:
19.73
4wozB-5dkkA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fno MANGANESE
LIPOXYGENASE

(Magnaporthe
oryzae) 		PF00305
(Lipoxygenase) 		4 SER A 123
LEU A 124
ASP A 125
LEU A 507
 None
 0.73A 4wozA-5fnoA:
undetectable
4wozB-5fnoA:
undetectable		 4wozA-5fnoA:
20.20
4wozB-5fnoA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin C/D BOX METHYLATION
GUIDE
RIBONUCLEOPROTEIN
COMPLEX ANOP56
SUBUNIT

(Sulfolobus
solfataricus) 		PF01798
(Nop) 		4 SER A 283
LEU A 284
ASP A 285
LEU A 278
 None
 0.88A 4wozA-5ginA:
undetectable
4wozB-5ginA:
undetectable		 4wozA-5ginA:
23.02
4wozB-5ginA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs7 CHOLOYLGLYCINE
HYDROLASE

(Enterococcus
faecalis) 		PF02275
(CBAH) 		4 THR A  31
ASP A  60
TYR A  64
LEU A  63
 None
 0.82A 4wozA-5gs7A:
undetectable
4wozB-5gs7A:
undetectable		 4wozA-5gs7A:
21.86
4wozB-5gs7A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hke BILE SALT HYDROLASE

(Lactobacillus
salivarius) 		PF02275
(CBAH) 		4 THR A  31
ASP A  60
TYR A  64
LEU A  63
 None
 0.84A 4wozA-5hkeA:
undetectable
4wozB-5hkeA:
undetectable		 4wozA-5hkeA:
24.51
4wozB-5hkeA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 LEU A 986
ASP A 987
TYR A 933
LEU A 930
 None
 0.98A 4wozA-5i6hA:
2.6
4wozB-5i6hA:
undetectable		 4wozA-5i6hA:
12.23
4wozB-5i6hA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6i ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN,ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		4 LEU A 986
ASP A 987
TYR A 933
LEU A 930
 None
 0.98A 4wozA-5i6iA:
undetectable
4wozB-5i6iA:
undetectable		 4wozA-5i6iA:
9.38
4wozB-5i6iA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id6 CPF1

(Lachnospiraceae
bacterium
ND2006) 		no annotation 4 LEU A 876
ASP A 877
TYR A 903
LEU A 899
 None
None
None
A  G  10 ( 4.4A)
 0.98A 4wozA-5id6A:
undetectable
4wozB-5id6A:
undetectable		 4wozA-5id6A:
14.22
4wozB-5id6A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7x DIMETHYLANILINE
MONOOXYGENASE,
PUTATIVE

(Aspergillus
flavus) 		PF00743
(FMO-like) 		4 SER A 296
LEU A 297
ASP A 298
LEU A 495
 None
 0.88A 4wozA-5j7xA:
undetectable
4wozB-5j7xA:
undetectable		 4wozA-5j7xA:
20.47
4wozB-5j7xA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nzz TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1

(Homo sapiens) 		no annotation 4 SER A 322
LEU A 323
ASP A 324
LEU A 369
 None
 0.82A 4wozA-5nzzA:
undetectable
4wozB-5nzzA:
undetectable		 4wozA-5nzzA:
undetectable
4wozB-5nzzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tiw SULFOTRANSFERASE

(Schistosoma
haematobium) 		no annotation 4 SER A 254
LEU A 255
ASP A 256
LEU A 249
 None
 0.88A 4wozA-5tiwA:
undetectable
4wozB-5tiwA:
undetectable		 4wozA-5tiwA:
22.05
4wozB-5tiwA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tja MUCOLIPIN-1

(Homo sapiens) 		no annotation 4 SER A 274
LEU A 275
TYR A 109
LEU A 106
 None
 0.95A 4wozA-5tjaA:
undetectable
4wozB-5tjaA:
undetectable		 4wozA-5tjaA:
18.91
4wozB-5tjaA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbb RNA PSEUDOURIDYLATE
SYNTHASE
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00849
(PseudoU_synth_2) 		4 SER A 246
LEU A 247
ASP A 248
LEU A 151
 None
 0.71A 4wozA-5vbbA:
undetectable
4wozB-5vbbA:
undetectable		 4wozA-5vbbA:
21.10
4wozB-5vbbA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yem CATALASE

(Mycothermus
thermophilus) 		no annotation 4 LEU A 362
ASP A 359
TYR A 369
LEU A 366
 None
None
HEM  A 704 (-3.8A)
None
 0.98A 4wozA-5yemA:
undetectable
4wozB-5yemA:
undetectable		 4wozA-5yemA:
undetectable
4wozB-5yemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co7 PREDICTED PROTEIN

(Nematostella
vectensis) 		no annotation 4 SER A 484
LEU A 485
ASP A 486
LEU A 576
 None
 0.63A 4wozA-6co7A:
undetectable
4wozB-6co7A:
undetectable		 4wozA-6co7A:
undetectable
4wozB-6co7A:
undetectable