SIMILAR PATTERNS OF AMINO ACIDS FOR 4WNW_B_RTZB602_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1akp | APOKEDARCIDIN (actinomyceteATCC 53650) |
PF00960(Neocarzinostat) | 3 | GLU A 51ILE A 111ALA A 34 | None | 0.67A | 4wnwB-1akpA:undetectable | 4wnwB-1akpA:12.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bg6 | N-(1-D-CARBOXYLETHYL)-L-NORVALINEDEHYDROGENASE (Arthrobactersp. 1C) |
PF02317(Octopine_DH)PF02558(ApbA) | 3 | GLU A 134ILE A 354ALA A 166 | None | 0.66A | 4wnwB-1bg6A:0.0 | 4wnwB-1bg6A:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dmw | PHENYLALANINEHYDROXYLASE (Homo sapiens) |
PF00351(Biopterin_H) | 3 | GLU A 183ILE A 164ALA A 156 | None | 0.60A | 4wnwB-1dmwA:0.0 | 4wnwB-1dmwA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dwa | MYROSINASE MA1 (Sinapis alba) |
PF00232(Glyco_hydro_1) | 3 | GLU M 314ILE M 225ALA M 233 | None | 0.59A | 4wnwB-1dwaM:0.0 | 4wnwB-1dwaM:18.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ea6 | PMS1 PROTEIN HOMOLOG2 (Homo sapiens) |
PF01119(DNA_mis_repair)PF13589(HATPase_c_3) | 3 | GLU A 44ILE A 292ALA A 190 | None | 0.60A | 4wnwB-1ea6A:0.0 | 4wnwB-1ea6A:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j6u | UDP-N-ACETYLMURAMATE-ALANINE LIGASE MURC (Thermotogamaritima) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 3 | GLU A 162ILE A 64ALA A 68 | None | 0.51A | 4wnwB-1j6uA:0.0 | 4wnwB-1j6uA:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kwm | PROCARBOXYPEPTIDASEB (Homo sapiens) |
PF00246(Peptidase_M14)PF02244(Propep_M14) | 3 | GLU A 175ILE A 139ALA A 70 | None | 0.63A | 4wnwB-1kwmA:0.0 | 4wnwB-1kwmA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l1f | GLUTAMATEDEHYDROGENASE 1 (Homo sapiens) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 3 | GLU A 320ILE A 363ALA A 345 | None | 0.62A | 4wnwB-1l1fA:0.0 | 4wnwB-1l1fA:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mt6 | SET9 (Homo sapiens) |
PF00856(SET)PF02493(MORN) | 3 | GLU A 212ILE A 275ALA A 295 | None | 0.63A | 4wnwB-1mt6A:0.0 | 4wnwB-1mt6A:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vl4 | PMBA-RELATED PROTEIN (Thermotogamaritima) |
PF01523(PmbA_TldD) | 3 | GLU A 358ILE A 201ALA A 209 | None | 0.66A | 4wnwB-1vl4A:undetectable | 4wnwB-1vl4A:22.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wd3 | ALPHA-L-ARABINOFURANOSIDASE B (Aspergilluskawachii) |
PF05270(AbfB)PF09206(ArabFuran-catal) | 3 | GLU A 161ILE A 291ALA A 33 | None | 0.65A | 4wnwB-1wd3A:undetectable | 4wnwB-1wd3A:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xwm | PHOSPHATE UPTAKEREGULATOR (Geobacillusstearothermophilus) |
PF01895(PhoU) | 3 | GLU A 24ILE A 86ALA A 94 | None | 0.53A | 4wnwB-1xwmA:undetectable | 4wnwB-1xwmA:17.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yb5 | QUINONEOXIDOREDUCTASE (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 3 | GLU A 150ILE A 244ALA A 169 | None | 0.63A | 4wnwB-1yb5A:undetectable | 4wnwB-1yb5A:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zli | CARBOXYPEPTIDASE B (Homo sapiens) |
PF00246(Peptidase_M14) | 3 | GLU A 175ILE A 139ALA A 70 | None | 0.62A | 4wnwB-1zliA:undetectable | 4wnwB-1zliA:19.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b39 | C3 (Bos taurus) |
PF00207(A2M)PF01759(NTR)PF01821(ANATO)PF01835(A2M_N)PF07677(A2M_recep)PF07678(A2M_comp)PF07703(A2M_N_2)PF10569(Thiol-ester_cl) | 3 | GLU A1046ILE A 166ALA A1093 | None | 0.66A | 4wnwB-2b39A:undetectable | 4wnwB-2b39A:15.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b4m | GLYCINEBETAINE-BINDINGPROTEIN (Bacillussubtilis) |
PF04069(OpuAC) | 3 | GLU A 181ILE A 21ALA A 206 | PBE A 311 ( 4.6A)NoneNone | 0.66A | 4wnwB-2b4mA:undetectable | 4wnwB-2b4mA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b4m | GLYCINEBETAINE-BINDINGPROTEIN (Bacillussubtilis) |
PF04069(OpuAC) | 3 | GLU A 181ILE A 27ALA A 206 | PBE A 311 ( 4.6A)PBE A 311 (-3.6A)None | 0.67A | 4wnwB-2b4mA:undetectable | 4wnwB-2b4mA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2di4 | CELL DIVISIONPROTEIN FTSH HOMOLOG (Aquifexaeolicus) |
PF01434(Peptidase_M41) | 3 | GLU A 567ILE A 417ALA A 562 | None | 0.60A | 4wnwB-2di4A:1.8 | 4wnwB-2di4A:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e3z | BETA-GLUCOSIDASE (Phanerochaetechrysosporium) |
PF00232(Glyco_hydro_1) | 3 | GLU A 285ILE A 196ALA A 204 | None | 0.56A | 4wnwB-2e3zA:undetectable | 4wnwB-2e3zA:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f8q | ALKALINETHERMOSTABLEENDOXYLANASE (Bacillus sp.NG-27) |
PF00331(Glyco_hydro_10) | 3 | GLU A 26ILE A 54ALA A 68 | None | 0.65A | 4wnwB-2f8qA:undetectable | 4wnwB-2f8qA:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hdn | ELONGATION FACTOREF-TU (Escherichiacoli) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2) | 3 | GLU B 232ILE B 366ALA B 293 | None | 0.63A | 4wnwB-2hdnB:undetectable | 4wnwB-2hdnB:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ijc | HYPOTHETICAL PROTEIN (Pseudomonasaeruginosa) |
PF02627(CMD) | 3 | GLU A 31ILE A 120ALA A 28 | None | 0.46A | 4wnwB-2ijcA:undetectable | 4wnwB-2ijcA:13.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kjp | UNCHARACTERIZEDPROTEIN YLBL (Bacillussubtilis) |
PF13180(PDZ_2) | 3 | GLU A 19ILE A 39ALA A 27 | None | 0.65A | 4wnwB-2kjpA:undetectable | 4wnwB-2kjpA:10.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o4d | HYPOTHETICAL PROTEINPA0269 (Pseudomonasaeruginosa) |
PF02627(CMD) | 3 | GLU A 31ILE A 120ALA A 28 | None | 0.64A | 4wnwB-2o4dA:undetectable | 4wnwB-2o4dA:16.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pan | GLYOXYLATECARBOLIGASE (Escherichiacoli) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 3 | GLU A 52ILE A 393ALA A 427 | NoneTDP A 801 ( 4.1A)None | 0.57A | 4wnwB-2panA:undetectable | 4wnwB-2panA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2prr | ALKYLHYDROPEROXIDASEAHPD CORE:UNCHARACTERIZEDPEROXIDASE-RELATEDPROTEIN (Cupriaviduspinatubonensis) |
PF02627(CMD) | 3 | GLU A 185ILE A 8ALA A 92 | None | 0.61A | 4wnwB-2prrA:undetectable | 4wnwB-2prrA:18.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rhk | NON-STRUCTURALPROTEIN 1 (Influenza Avirus) |
PF00600(Flu_NS1) | 3 | GLU A 172ILE A 137ALA A 202 | None | 0.44A | 4wnwB-2rhkA:undetectable | 4wnwB-2rhkA:13.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w6d | DYNAMIN FAMILYPROTEIN (Nostocpunctiforme) |
PF00350(Dynamin_N) | 3 | GLU A 622ILE A 389ALA A 397 | None | 0.59A | 4wnwB-2w6dA:2.1 | 4wnwB-2w6dA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xhz | ARABINOSE5-PHOSPHATEISOMERASE (Escherichiacoli) |
PF01380(SIS) | 3 | GLU A 23ILE A 63ALA A 159 | None | 0.66A | 4wnwB-2xhzA:undetectable | 4wnwB-2xhzA:16.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yzs | PUTATIVEUNCHARACTERIZEDPROTEIN (Aquifexaeolicus) |
PF01867(Cas_Cas1) | 3 | GLU A 143ILE A 178ALA A 220 | None | 0.51A | 4wnwB-2yzsA:undetectable | 4wnwB-2yzsA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z8z | LIPASE (Pseudomonas sp.MIS38) |
PF00353(HemolysinCabind) | 3 | GLU A 112ILE A 138ALA A 119 | None | 0.64A | 4wnwB-2z8zA:undetectable | 4wnwB-2z8zA:23.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ada | SARCOSINE OXIDASEBETA SUBUNIT (Corynebacteriumsp. U-96) |
PF01266(DAO) | 3 | GLU B 52ILE B 327ALA B 62 | FAD B 1 (-2.8A)NoneFMN B 4 (-4.1A) | 0.57A | 4wnwB-3adaB:undetectable | 4wnwB-3adaB:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3agr | NUCLEOSIDETRIPHOSPHATEHYDROLASE (Neosporacaninum) |
PF01150(GDA1_CD39) | 3 | GLU A 253ILE A 207ALA A 257 | None | 0.58A | 4wnwB-3agrA:undetectable | 4wnwB-3agrA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3at6 | BETA-GLOBIN (Podocnemisunifilis) |
PF00042(Globin) | 3 | GLU B 101ILE B 109ALA B 138 | None | 0.50A | 4wnwB-3at6B:undetectable | 4wnwB-3at6B:16.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bcz | PROTEIN MEMO1 (Homo sapiens) |
PF01875(Memo) | 3 | GLU A 166ILE A 224ALA A 255 | GOL A 303 (-3.7A)NoneNone | 0.60A | 4wnwB-3bczA:undetectable | 4wnwB-3bczA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c1l | PUTATIVE ANTIOXIDANTDEFENSE PROTEINMLR4105 (Mesorhizobiumjaponicum) |
PF02627(CMD) | 3 | GLU A 181ILE A 5ALA A 88 | NoneNonePEG A 190 ( 3.8A) | 0.66A | 4wnwB-3c1lA:undetectable | 4wnwB-3c1lA:16.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cbo | HISTONE-LYSINEN-METHYLTRANSFERASESETD7 (Homo sapiens) |
PF00856(SET) | 3 | GLU A 212ILE A 275ALA A 295 | None | 0.60A | 4wnwB-3cboA:undetectable | 4wnwB-3cboA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cdi | POLYNUCLEOTIDEPHOSPHORYLASE (Escherichiacoli) |
PF01138(RNase_PH)PF03725(RNase_PH_C)PF03726(PNPase) | 3 | GLU A 88ILE A 151ALA A 138 | None | 0.47A | 4wnwB-3cdiA:2.2 | 4wnwB-3cdiA:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cwc | PUTATIVE GLYCERATEKINASE 2 (Salmonellaenterica) |
PF02595(Gly_kinase) | 3 | GLU A 217ILE A 166ALA A 214 | None | 0.66A | 4wnwB-3cwcA:undetectable | 4wnwB-3cwcA:24.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ee9 | NON-STRUCTURALPROTEIN 1 (Influenza Avirus) |
PF00600(Flu_NS1) | 3 | GLU A 172ILE A 137ALA A 202 | None | 0.60A | 4wnwB-3ee9A:undetectable | 4wnwB-3ee9A:15.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fj7 | MAJOR ANTIGENICPEPTIDE PEB3 (Campylobacterjejuni) |
PF13531(SBP_bac_11) | 3 | GLU A 206ILE A 127ALA A 102 | None | 0.62A | 4wnwB-3fj7A:undetectable | 4wnwB-3fj7A:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g7r | PUTATIVETRANSCRIPTIONALREGULATOR (Streptomycescoelicolor) |
PF00440(TetR_N) | 3 | GLU A 118ILE A 26ALA A 111 | None | 0.59A | 4wnwB-3g7rA:0.6 | 4wnwB-3g7rA:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iwg | ACETYLTRANSFERASE,GNAT FAMILY (Colwelliapsychrerythraea) |
PF00583(Acetyltransf_1) | 3 | GLU A 244ILE A 210ALA A 249 | NoneNoneSO4 A 501 ( 4.2A) | 0.64A | 4wnwB-3iwgA:undetectable | 4wnwB-3iwgA:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j9q | SHEATH (Pseudomonasaeruginosa) |
PF04984(Phage_sheath_1)PF17482(Phage_sheath_1C) | 3 | GLU A 214ILE A 19ALA A 23 | None | 0.53A | 4wnwB-3j9qA:undetectable | 4wnwB-3j9qA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jux | PROTEIN TRANSLOCASESUBUNIT SECA (Thermotogamaritima) |
PF00271(Helicase_C)PF01043(SecA_PP_bind)PF07516(SecA_SW)PF07517(SecA_DEAD) | 3 | GLU A 425ILE A 563ALA A 419 | None | 0.64A | 4wnwB-3juxA:undetectable | 4wnwB-3juxA:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kz1 | RHO GUANINENUCLEOTIDE EXCHANGEFACTOR 11 (Homo sapiens) |
PF00621(RhoGEF) | 3 | GLU A 928ILE A 876ALA A 839 | None | 0.49A | 4wnwB-3kz1A:undetectable | 4wnwB-3kz1A:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ly1 | PUTATIVEHISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Pectobacteriumatrosepticum) |
PF00155(Aminotran_1_2) | 3 | GLU A 119ILE A 151ALA A 124 | None | 0.61A | 4wnwB-3ly1A:undetectable | 4wnwB-3ly1A:20.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mc2 | INHIBITOR OFCARBONIC ANHYDRASE (Mus musculus) |
PF00405(Transferrin) | 3 | GLU A 345ILE A 372ALA A 363 | None | 0.59A | 4wnwB-3mc2A:undetectable | 4wnwB-3mc2A:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3moy | PROBABLE ENOYL-COAHYDRATASE (Mycolicibacteriumsmegmatis) |
PF00378(ECH_1) | 3 | GLU A 113ILE A 69ALA A 64 | EDO A 262 (-2.7A)NoneNone | 0.58A | 4wnwB-3moyA:undetectable | 4wnwB-3moyA:23.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mpn | TRANSPORTER (Aquifexaeolicus) |
PF00209(SNF) | 3 | GLU A 6ILE A 357ALA A 365 | None | 0.58A | 4wnwB-3mpnA:undetectable | 4wnwB-3mpnA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nu8 | AMINOTRANSFERASEWBPE (Pseudomonasaeruginosa) |
PF01041(DegT_DnrJ_EryC1) | 3 | GLU A 202ILE A 222ALA A 69 | None | 0.63A | 4wnwB-3nu8A:undetectable | 4wnwB-3nu8A:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qde | CELLOBIOSEPHOSPHORYLASE (Ruminiclostridiumthermocellum) |
PF06165(Glyco_transf_36)PF17167(Glyco_hydro_36) | 3 | GLU A 684ILE A 330ALA A 679 | None | 0.53A | 4wnwB-3qdeA:undetectable | 4wnwB-3qdeA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3swt | TAURINE CATABOLISMDIOXYGENASE, TAUD (Mycobacteriummarinum) |
PF02668(TauD) | 3 | GLU A 195ILE A 247ALA A 252 | None | 0.37A | 4wnwB-3swtA:undetectable | 4wnwB-3swtA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ujg | SERINE/THREONINE-PROTEIN KINASE SRK2E (Arabidopsisthaliana) |
PF00069(Pkinase) | 3 | GLU A 60ILE A 305ALA A 313 | None | 0.65A | 4wnwB-3ujgA:undetectable | 4wnwB-3ujgA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ci2 | PROTEIN CEREBLON (Gallus gallus) |
PF02190(LON_substr_bdg)PF03226(Yippee-Mis18) | 3 | GLU B 360ILE B 298ALA B 287 | None | 0.51A | 4wnwB-4ci2B:undetectable | 4wnwB-4ci2B:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cpn | NEURAMINIDASE (Influenza Bvirus) |
PF00064(Neur) | 3 | GLU A 186ILE A 170ALA A 180 | None | 0.61A | 4wnwB-4cpnA:undetectable | 4wnwB-4cpnA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cvy | DIOXYGENASERV3406/MT3514 (Mycobacteriumtuberculosis) |
PF02668(TauD) | 3 | GLU A 191ILE A 243ALA A 40 | None | 0.60A | 4wnwB-4cvyA:undetectable | 4wnwB-4cvyA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cvy | DIOXYGENASERV3406/MT3514 (Mycobacteriumtuberculosis) |
PF02668(TauD) | 3 | GLU A 191ILE A 243ALA A 248 | None | 0.38A | 4wnwB-4cvyA:undetectable | 4wnwB-4cvyA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dji | PROBABLEGLUTAMATE/GAMMA-AMINOBUTYRATE ANTIPORTER (Escherichiacoli) |
PF13520(AA_permease_2) | 3 | GLU A 31ILE A 99ALA A 370 | None | 0.66A | 4wnwB-4djiA:0.5 | 4wnwB-4djiA:23.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ehj | PHOSPHOGLYCERATEKINASE (Francisellatularensis) |
PF00162(PGK) | 3 | GLU A 225ILE A 298ALA A 218 | None | 0.62A | 4wnwB-4ehjA:undetectable | 4wnwB-4ehjA:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ewt | PEPTIDASE,M20/M25/M40 FAMILY (Staphylococcusaureus) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 3 | GLU A 28ILE A 60ALA A 137 | None | 0.64A | 4wnwB-4ewtA:undetectable | 4wnwB-4ewtA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fmk | POLIOVIRUSRECEPTOR-RELATEDPROTEIN 2 (Mus musculus) |
PF07686(V-set)PF08205(C2-set_2) | 3 | GLU A 234ILE A 210ALA A 151 | None | 0.64A | 4wnwB-4fmkA:undetectable | 4wnwB-4fmkA:21.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fxb | PUTATIVE CYTOCHROMEP450 (Streptomycescoelicolor) |
PF00067(p450) | 3 | GLU A 91ILE A 322ALA A 75 | None | 0.65A | 4wnwB-4fxbA:29.6 | 4wnwB-4fxbA:26.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hnr | CHEMOTAXIS PROTEINCHEY (Vibrio cholerae) |
PF00072(Response_reg) | 3 | GLU A 36ILE A 11ALA A 6 | None | 0.45A | 4wnwB-4hnrA:undetectable | 4wnwB-4hnrA:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i8q | PUTATIVE BETAINEALDEHYDEDEHYROGENASE (Solanumlycopersicum) |
PF00171(Aldedh) | 3 | GLU A 119ILE A 200ALA A 173 | None | 0.63A | 4wnwB-4i8qA:undetectable | 4wnwB-4i8qA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j5i | ALPHA-KETOGLUTARATE-DEPENDENT TAURINEDIOXYGENASE (Mycolicibacteriumsmegmatis) |
PF02668(TauD) | 3 | GLU A 188ILE A 44ALA A 245 | None | 0.65A | 4wnwB-4j5iA:undetectable | 4wnwB-4j5iA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j5i | ALPHA-KETOGLUTARATE-DEPENDENT TAURINEDIOXYGENASE (Mycolicibacteriumsmegmatis) |
PF02668(TauD) | 3 | GLU A 188ILE A 240ALA A 245 | None | 0.40A | 4wnwB-4j5iA:undetectable | 4wnwB-4j5iA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ld7 | DIMETHYLALLYLTRYPTOPHAN SYNTHASE (Aspergillusfischeri) |
PF11991(Trp_DMAT) | 3 | GLU A 344ILE A 206ALA A 268 | None | 0.64A | 4wnwB-4ld7A:undetectable | 4wnwB-4ld7A:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mdp | BETA-GLUCOSIDASE (Humicola grisea) |
PF00232(Glyco_hydro_1) | 3 | GLU A 292ILE A 202ALA A 210 | NonePEG A 504 ( 4.4A)None | 0.63A | 4wnwB-4mdpA:undetectable | 4wnwB-4mdpA:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n4u | PUTATIVE ABCTRANSPORTERPERIPLASMICSOLUTE-BINDINGPROTEIN (Bordetellabronchiseptica) |
PF03480(DctP) | 3 | GLU A 269ILE A 212ALA A 275 | None | 0.45A | 4wnwB-4n4uA:undetectable | 4wnwB-4n4uA:24.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nzs | BETA-KETOTHIOLASEBKTB (Cupriavidusnecator) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 3 | GLU A 4ILE A 390ALA A 101 | None | 0.59A | 4wnwB-4nzsA:undetectable | 4wnwB-4nzsA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o1e | DIHYDROPTEROATESYNTHASE DHPS (Desulfitobacteriumhafniense) |
PF00809(Pterin_bind) | 3 | GLU A 107ILE A 140ALA A 148 | None | 0.58A | 4wnwB-4o1eA:undetectable | 4wnwB-4o1eA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ofz | TREHALOSE-PHOSPHATASE (Brugia malayi) |
no annotation | 3 | GLU A 386ILE A 395ALA A 389 | None | 0.64A | 4wnwB-4ofzA:undetectable | 4wnwB-4ofzA:23.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ol9 | PUTATIVE2-DEHYDROPANTOATE2-REDUCTASE (Mycobacteriumtuberculosis) |
PF02558(ApbA)PF08546(ApbA_C) | 3 | GLU A 258ILE A 121ALA A 72 | NAP A 301 (-2.8A)NoneNone | 0.66A | 4wnwB-4ol9A:undetectable | 4wnwB-4ol9A:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4raa | PUTATIVE EXPORTEDPROTEIN (Bacteroidesfragilis) |
PF17170(DUF5128) | 3 | GLU A 145ILE A 108ALA A 124 | None | 0.51A | 4wnwB-4raaA:undetectable | 4wnwB-4raaA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u30 | TRYPSTATIN (Homo sapiens) |
no annotation | 3 | GLU X 50ILE X 18ALA X 22 | None | 0.66A | 4wnwB-4u30X:undetectable | 4wnwB-4u30X:8.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y0e | PUTATIVE DIOXYGENASE (Mycobacteroidesabscessus) |
PF02668(TauD) | 3 | GLU A 202ILE A 254ALA A 259 | MPD A 402 (-2.9A)NoneNone | 0.43A | 4wnwB-4y0eA:undetectable | 4wnwB-4y0eA:23.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aa5 | NIFE-HYDROGENASELARGE SUBUNIT, HOFG (Cupriavidusnecator) |
PF00374(NiFeSe_Hases) | 3 | GLU C 261ILE C 267ALA C 543 | None | 0.62A | 4wnwB-5aa5C:undetectable | 4wnwB-5aa5C:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d6o | HOMOSERINEO-ACETYLTRANSFERASE (Corynebacteriumglutamicum) |
PF00561(Abhydrolase_1) | 3 | GLU A 307ILE A 115ALA A 280 | None | 0.66A | 4wnwB-5d6oA:1.3 | 4wnwB-5d6oA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dx9 | TREHALOSE-6-PHOSPHATE PHOSPHATASE (Cryptococcusneoformans) |
PF02358(Trehalose_PPase) | 3 | GLU A 249ILE A 100ALA A 105 | None | 0.64A | 4wnwB-5dx9A:undetectable | 4wnwB-5dx9A:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fic | SPHINGOMYELINPHOSPHODIESTERASE (Mus musculus) |
PF00149(Metallophos) | 3 | GLU A 460ILE A 424ALA A 477 | None | 0.65A | 4wnwB-5ficA:undetectable | 4wnwB-5ficA:23.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fur | TRANSCRIPTIONINITIATION FACTORTFIID SUBUNIT 2 (Homo sapiens) |
no annotation | 3 | GLU I 398ILE I 377ALA I 453 | None | 0.56A | 4wnwB-5furI:undetectable | 4wnwB-5furI:17.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h0i | ASPARAGINYLENDOPEPTIDASE (Oldenlandiaaffinis) |
PF01650(Peptidase_C13) | 3 | GLU A 405ILE A 457ALA A 409 | None | 0.63A | 4wnwB-5h0iA:undetectable | 4wnwB-5h0iA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hqn | SPHINGOMYELINPHOSPHODIESTERASE (Mus musculus) |
PF00149(Metallophos) | 3 | GLU A 460ILE A 424ALA A 477 | None | 0.63A | 4wnwB-5hqnA:undetectable | 4wnwB-5hqnA:23.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hvf | CARBOXYPEPTIDASE B2 (Homo sapiens) |
PF00246(Peptidase_M14)PF02244(Propep_M14) | 3 | GLU A 266ILE A 229ALA A 160 | None | 0.59A | 4wnwB-5hvfA:undetectable | 4wnwB-5hvfA:19.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5id6 | CPF1 (LachnospiraceaebacteriumND2006) |
no annotation | 3 | GLU A1168ILE A1072ALA A1179 | None | 0.65A | 4wnwB-5id6A:undetectable | 4wnwB-5id6A:17.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j1q | CARBOXYPEPTIDASE B (Sus scrofa) |
PF00246(Peptidase_M14) | 3 | GLU A 175ILE A 139ALA A 70 | None | 0.51A | 4wnwB-5j1qA:undetectable | 4wnwB-5j1qA:19.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k3h | ACYL-COENZYME AOXIDASE (Caenorhabditiselegans) |
PF01756(ACOX)PF02770(Acyl-CoA_dh_M)PF14749(Acyl-CoA_ox_N) | 3 | GLU A 360ILE A 492ALA A 353 | None | 0.64A | 4wnwB-5k3hA:undetectable | 4wnwB-5k3hA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k94 | MALTOSE-BINDINGPERIPLASMICPROTEIN,PROTEINTRANSLOCASE SUBUNITSECA,MALTOSE-BINDINGPERIPLASMIC PROTEIN (Escherichiacoli) |
PF01043(SecA_PP_bind)PF01547(SBP_bac_1)PF13416(SBP_bac_8) | 3 | GLU A 368ILE A 335ALA A 356 | None | 0.53A | 4wnwB-5k94A:undetectable | 4wnwB-5k94A:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kdj | F5/8 TYPE C DOMAINPROTEIN (Clostridiumperfringens) |
no annotation | 3 | GLU B 845ILE B 861ALA B 869 | None | 0.59A | 4wnwB-5kdjB:undetectable | 4wnwB-5kdjB:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kds | F5/8 TYPE C DOMAINPROTEIN (Clostridiumperfringens) |
PF13402(Peptidase_M60) | 3 | GLU A 845ILE A 861ALA A 869 | None | 0.54A | 4wnwB-5kdsA:undetectable | 4wnwB-5kdsA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5msc | CARBOXYLIC ACIDREDUCTASE (Nocardiaiowensis) |
PF00501(AMP-binding) | 3 | GLU A 99ILE A 126ALA A 134 | None | 0.65A | 4wnwB-5mscA:undetectable | 4wnwB-5mscA:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n29 | CTP SYNTHASE (Trypanosomabrucei) |
PF00117(GATase) | 3 | GLU A 370ILE A 427ALA A 404 | None | 0.66A | 4wnwB-5n29A:undetectable | 4wnwB-5n29A:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nd1 | CAPSID PROTEIN (Rosellinianecatrixquadrivirus 1) |
no annotation | 3 | GLU A 361ILE B 998ALA A 358 | None | 0.53A | 4wnwB-5nd1A:undetectable | 4wnwB-5nd1A:10.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vn6 | TAURINE DIOXYGENASE (Burkholderiaambifaria) |
PF02668(TauD) | 3 | GLU A 187ILE A 250ALA A 255 | None | 0.47A | 4wnwB-5vn6A:undetectable | 4wnwB-5vn6A:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zby | HYDROGENASEMATURATION PROTEASEHYCI (Thermococcuskodakarensis) |
no annotation | 3 | GLU A 134ILE A 82ALA A 28 | None | 0.66A | 4wnwB-5zbyA:undetectable | 4wnwB-5zbyA:11.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bcq | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY MMEMBER 4 (Mus musculus) |
no annotation | 3 | GLU B 824ILE B 897ALA B 817 | None | 0.49A | 4wnwB-6bcqB:undetectable | 4wnwB-6bcqB:12.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bq6 | THERMOSPERMINESYNTHASE (Medicagotruncatula) |
no annotation | 3 | GLU A 109ILE A 248ALA A 67 | None | 0.63A | 4wnwB-6bq6A:undetectable | 4wnwB-6bq6A:11.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cdd | NPL4 ZINC FINGER (Chaetomiumthermophilum) |
no annotation | 3 | GLU A 513ILE A 267ALA A 274 | None | 0.59A | 4wnwB-6cddA:undetectable | 4wnwB-6cddA:10.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gdt | - (-) |
no annotation | 3 | GLU A 442ILE A 401ALA A 475 | None | 0.50A | 4wnwB-6gdtA:undetectable | 4wnwB-6gdtA:undetectable |