SIMILAR PATTERNS OF AMINO ACIDS FOR 4WNW_B_RTZB602_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akp APOKEDARCIDIN

(actinomycete
ATCC 53650)
PF00960
(Neocarzinostat)
3 GLU A  51
ILE A 111
ALA A  34
None
0.67A 4wnwB-1akpA:
undetectable
4wnwB-1akpA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg6 N-(1-D-CARBOXYLETHYL
)-L-NORVALINE
DEHYDROGENASE


(Arthrobacter
sp. 1C)
PF02317
(Octopine_DH)
PF02558
(ApbA)
3 GLU A 134
ILE A 354
ALA A 166
None
0.66A 4wnwB-1bg6A:
0.0
4wnwB-1bg6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmw PHENYLALANINE
HYDROXYLASE


(Homo sapiens)
PF00351
(Biopterin_H)
3 GLU A 183
ILE A 164
ALA A 156
None
0.60A 4wnwB-1dmwA:
0.0
4wnwB-1dmwA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba)
PF00232
(Glyco_hydro_1)
3 GLU M 314
ILE M 225
ALA M 233
None
0.59A 4wnwB-1dwaM:
0.0
4wnwB-1dwaM:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea6 PMS1 PROTEIN HOMOLOG
2


(Homo sapiens)
PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3)
3 GLU A  44
ILE A 292
ALA A 190
None
0.60A 4wnwB-1ea6A:
0.0
4wnwB-1ea6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC


(Thermotoga
maritima)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
3 GLU A 162
ILE A  64
ALA A  68
None
0.51A 4wnwB-1j6uA:
0.0
4wnwB-1j6uA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwm PROCARBOXYPEPTIDASE
B


(Homo sapiens)
PF00246
(Peptidase_M14)
PF02244
(Propep_M14)
3 GLU A 175
ILE A 139
ALA A  70
None
0.63A 4wnwB-1kwmA:
0.0
4wnwB-1kwmA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1f GLUTAMATE
DEHYDROGENASE 1


(Homo sapiens)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
3 GLU A 320
ILE A 363
ALA A 345
None
0.62A 4wnwB-1l1fA:
0.0
4wnwB-1l1fA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt6 SET9

(Homo sapiens)
PF00856
(SET)
PF02493
(MORN)
3 GLU A 212
ILE A 275
ALA A 295
None
0.63A 4wnwB-1mt6A:
0.0
4wnwB-1mt6A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl4 PMBA-RELATED PROTEIN

(Thermotoga
maritima)
PF01523
(PmbA_TldD)
3 GLU A 358
ILE A 201
ALA A 209
None
0.66A 4wnwB-1vl4A:
undetectable
4wnwB-1vl4A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B


(Aspergillus
kawachii)
PF05270
(AbfB)
PF09206
(ArabFuran-catal)
3 GLU A 161
ILE A 291
ALA A  33
None
0.65A 4wnwB-1wd3A:
undetectable
4wnwB-1wd3A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwm PHOSPHATE UPTAKE
REGULATOR


(Geobacillus
stearothermophilus)
PF01895
(PhoU)
3 GLU A  24
ILE A  86
ALA A  94
None
0.53A 4wnwB-1xwmA:
undetectable
4wnwB-1xwmA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb5 QUINONE
OXIDOREDUCTASE


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
3 GLU A 150
ILE A 244
ALA A 169
None
0.63A 4wnwB-1yb5A:
undetectable
4wnwB-1yb5A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zli CARBOXYPEPTIDASE B

(Homo sapiens)
PF00246
(Peptidase_M14)
3 GLU A 175
ILE A 139
ALA A  70
None
0.62A 4wnwB-1zliA:
undetectable
4wnwB-1zliA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus)
PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
3 GLU A1046
ILE A 166
ALA A1093
None
0.66A 4wnwB-2b39A:
undetectable
4wnwB-2b39A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4m GLYCINE
BETAINE-BINDING
PROTEIN


(Bacillus
subtilis)
PF04069
(OpuAC)
3 GLU A 181
ILE A  21
ALA A 206
PBE  A 311 ( 4.6A)
None
None
0.66A 4wnwB-2b4mA:
undetectable
4wnwB-2b4mA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4m GLYCINE
BETAINE-BINDING
PROTEIN


(Bacillus
subtilis)
PF04069
(OpuAC)
3 GLU A 181
ILE A  27
ALA A 206
PBE  A 311 ( 4.6A)
PBE  A 311 (-3.6A)
None
0.67A 4wnwB-2b4mA:
undetectable
4wnwB-2b4mA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2di4 CELL DIVISION
PROTEIN FTSH HOMOLOG


(Aquifex
aeolicus)
PF01434
(Peptidase_M41)
3 GLU A 567
ILE A 417
ALA A 562
None
0.60A 4wnwB-2di4A:
1.8
4wnwB-2di4A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium)
PF00232
(Glyco_hydro_1)
3 GLU A 285
ILE A 196
ALA A 204
None
0.56A 4wnwB-2e3zA:
undetectable
4wnwB-2e3zA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE


(Bacillus sp.
NG-27)
PF00331
(Glyco_hydro_10)
3 GLU A  26
ILE A  54
ALA A  68
None
0.65A 4wnwB-2f8qA:
undetectable
4wnwB-2f8qA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdn ELONGATION FACTOR
EF-TU


(Escherichia
coli)
PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
3 GLU B 232
ILE B 366
ALA B 293
None
0.63A 4wnwB-2hdnB:
undetectable
4wnwB-2hdnB:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijc HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa)
PF02627
(CMD)
3 GLU A  31
ILE A 120
ALA A  28
None
0.46A 4wnwB-2ijcA:
undetectable
4wnwB-2ijcA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kjp UNCHARACTERIZED
PROTEIN YLBL


(Bacillus
subtilis)
PF13180
(PDZ_2)
3 GLU A  19
ILE A  39
ALA A  27
None
0.65A 4wnwB-2kjpA:
undetectable
4wnwB-2kjpA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4d HYPOTHETICAL PROTEIN
PA0269


(Pseudomonas
aeruginosa)
PF02627
(CMD)
3 GLU A  31
ILE A 120
ALA A  28
None
0.64A 4wnwB-2o4dA:
undetectable
4wnwB-2o4dA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pan GLYOXYLATE
CARBOLIGASE


(Escherichia
coli)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
3 GLU A  52
ILE A 393
ALA A 427
None
TDP  A 801 ( 4.1A)
None
0.57A 4wnwB-2panA:
undetectable
4wnwB-2panA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prr ALKYLHYDROPEROXIDASE
AHPD CORE:
UNCHARACTERIZED
PEROXIDASE-RELATED
PROTEIN


(Cupriavidus
pinatubonensis)
PF02627
(CMD)
3 GLU A 185
ILE A   8
ALA A  92
None
0.61A 4wnwB-2prrA:
undetectable
4wnwB-2prrA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhk NON-STRUCTURAL
PROTEIN 1


(Influenza A
virus)
PF00600
(Flu_NS1)
3 GLU A 172
ILE A 137
ALA A 202
None
0.44A 4wnwB-2rhkA:
undetectable
4wnwB-2rhkA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6d DYNAMIN FAMILY
PROTEIN


(Nostoc
punctiforme)
PF00350
(Dynamin_N)
3 GLU A 622
ILE A 389
ALA A 397
None
0.59A 4wnwB-2w6dA:
2.1
4wnwB-2w6dA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhz ARABINOSE
5-PHOSPHATE
ISOMERASE


(Escherichia
coli)
PF01380
(SIS)
3 GLU A  23
ILE A  63
ALA A 159
None
0.66A 4wnwB-2xhzA:
undetectable
4wnwB-2xhzA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN


(Aquifex
aeolicus)
PF01867
(Cas_Cas1)
3 GLU A 143
ILE A 178
ALA A 220
None
0.51A 4wnwB-2yzsA:
undetectable
4wnwB-2yzsA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38)
PF00353
(HemolysinCabind)
3 GLU A 112
ILE A 138
ALA A 119
None
0.64A 4wnwB-2z8zA:
undetectable
4wnwB-2z8zA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT


(Corynebacterium
sp. U-96)
PF01266
(DAO)
3 GLU B  52
ILE B 327
ALA B  62
FAD  B   1 (-2.8A)
None
FMN  B   4 (-4.1A)
0.57A 4wnwB-3adaB:
undetectable
4wnwB-3adaB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agr NUCLEOSIDE
TRIPHOSPHATE
HYDROLASE


(Neospora
caninum)
PF01150
(GDA1_CD39)
3 GLU A 253
ILE A 207
ALA A 257
None
0.58A 4wnwB-3agrA:
undetectable
4wnwB-3agrA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at6 BETA-GLOBIN

(Podocnemis
unifilis)
PF00042
(Globin)
3 GLU B 101
ILE B 109
ALA B 138
None
0.50A 4wnwB-3at6B:
undetectable
4wnwB-3at6B:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcz PROTEIN MEMO1

(Homo sapiens)
PF01875
(Memo)
3 GLU A 166
ILE A 224
ALA A 255
GOL  A 303 (-3.7A)
None
None
0.60A 4wnwB-3bczA:
undetectable
4wnwB-3bczA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1l PUTATIVE ANTIOXIDANT
DEFENSE PROTEIN
MLR4105


(Mesorhizobium
japonicum)
PF02627
(CMD)
3 GLU A 181
ILE A   5
ALA A  88
None
None
PEG  A 190 ( 3.8A)
0.66A 4wnwB-3c1lA:
undetectable
4wnwB-3c1lA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7


(Homo sapiens)
PF00856
(SET)
3 GLU A 212
ILE A 275
ALA A 295
None
0.60A 4wnwB-3cboA:
undetectable
4wnwB-3cboA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdi POLYNUCLEOTIDE
PHOSPHORYLASE


(Escherichia
coli)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase)
3 GLU A  88
ILE A 151
ALA A 138
None
0.47A 4wnwB-3cdiA:
2.2
4wnwB-3cdiA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwc PUTATIVE GLYCERATE
KINASE 2


(Salmonella
enterica)
PF02595
(Gly_kinase)
3 GLU A 217
ILE A 166
ALA A 214
None
0.66A 4wnwB-3cwcA:
undetectable
4wnwB-3cwcA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ee9 NON-STRUCTURAL
PROTEIN 1


(Influenza A
virus)
PF00600
(Flu_NS1)
3 GLU A 172
ILE A 137
ALA A 202
None
0.60A 4wnwB-3ee9A:
undetectable
4wnwB-3ee9A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj7 MAJOR ANTIGENIC
PEPTIDE PEB3


(Campylobacter
jejuni)
PF13531
(SBP_bac_11)
3 GLU A 206
ILE A 127
ALA A 102
None
0.62A 4wnwB-3fj7A:
undetectable
4wnwB-3fj7A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR


(Streptomyces
coelicolor)
PF00440
(TetR_N)
3 GLU A 118
ILE A  26
ALA A 111
None
0.59A 4wnwB-3g7rA:
0.6
4wnwB-3g7rA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwg ACETYLTRANSFERASE,
GNAT FAMILY


(Colwellia
psychrerythraea)
PF00583
(Acetyltransf_1)
3 GLU A 244
ILE A 210
ALA A 249
None
None
SO4  A 501 ( 4.2A)
0.64A 4wnwB-3iwgA:
undetectable
4wnwB-3iwgA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9q SHEATH

(Pseudomonas
aeruginosa)
PF04984
(Phage_sheath_1)
PF17482
(Phage_sheath_1C)
3 GLU A 214
ILE A  19
ALA A  23
None
0.53A 4wnwB-3j9qA:
undetectable
4wnwB-3j9qA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jux PROTEIN TRANSLOCASE
SUBUNIT SECA


(Thermotoga
maritima)
PF00271
(Helicase_C)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD)
3 GLU A 425
ILE A 563
ALA A 419
None
0.64A 4wnwB-3juxA:
undetectable
4wnwB-3juxA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11


(Homo sapiens)
PF00621
(RhoGEF)
3 GLU A 928
ILE A 876
ALA A 839
None
0.49A 4wnwB-3kz1A:
undetectable
4wnwB-3kz1A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Pectobacterium
atrosepticum)
PF00155
(Aminotran_1_2)
3 GLU A 119
ILE A 151
ALA A 124
None
0.61A 4wnwB-3ly1A:
undetectable
4wnwB-3ly1A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE


(Mus musculus)
PF00405
(Transferrin)
3 GLU A 345
ILE A 372
ALA A 363
None
0.59A 4wnwB-3mc2A:
undetectable
4wnwB-3mc2A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moy PROBABLE ENOYL-COA
HYDRATASE


(Mycolicibacterium
smegmatis)
PF00378
(ECH_1)
3 GLU A 113
ILE A  69
ALA A  64
EDO  A 262 (-2.7A)
None
None
0.58A 4wnwB-3moyA:
undetectable
4wnwB-3moyA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus)
PF00209
(SNF)
3 GLU A   6
ILE A 357
ALA A 365
None
0.58A 4wnwB-3mpnA:
undetectable
4wnwB-3mpnA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nu8 AMINOTRANSFERASE
WBPE


(Pseudomonas
aeruginosa)
PF01041
(DegT_DnrJ_EryC1)
3 GLU A 202
ILE A 222
ALA A  69
None
0.63A 4wnwB-3nu8A:
undetectable
4wnwB-3nu8A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE


(Ruminiclostridium
thermocellum)
PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36)
3 GLU A 684
ILE A 330
ALA A 679
None
0.53A 4wnwB-3qdeA:
undetectable
4wnwB-3qdeA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swt TAURINE CATABOLISM
DIOXYGENASE, TAUD


(Mycobacterium
marinum)
PF02668
(TauD)
3 GLU A 195
ILE A 247
ALA A 252
None
0.37A 4wnwB-3swtA:
undetectable
4wnwB-3swtA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujg SERINE/THREONINE-PRO
TEIN KINASE SRK2E


(Arabidopsis
thaliana)
PF00069
(Pkinase)
3 GLU A  60
ILE A 305
ALA A 313
None
0.65A 4wnwB-3ujgA:
undetectable
4wnwB-3ujgA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus)
PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18)
3 GLU B 360
ILE B 298
ALA B 287
None
0.51A 4wnwB-4ci2B:
undetectable
4wnwB-4ci2B:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpn NEURAMINIDASE

(Influenza B
virus)
PF00064
(Neur)
3 GLU A 186
ILE A 170
ALA A 180
None
0.61A 4wnwB-4cpnA:
undetectable
4wnwB-4cpnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvy DIOXYGENASE
RV3406/MT3514


(Mycobacterium
tuberculosis)
PF02668
(TauD)
3 GLU A 191
ILE A 243
ALA A  40
None
0.60A 4wnwB-4cvyA:
undetectable
4wnwB-4cvyA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvy DIOXYGENASE
RV3406/MT3514


(Mycobacterium
tuberculosis)
PF02668
(TauD)
3 GLU A 191
ILE A 243
ALA A 248
None
0.38A 4wnwB-4cvyA:
undetectable
4wnwB-4cvyA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER


(Escherichia
coli)
PF13520
(AA_permease_2)
3 GLU A  31
ILE A  99
ALA A 370
None
0.66A 4wnwB-4djiA:
0.5
4wnwB-4djiA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehj PHOSPHOGLYCERATE
KINASE


(Francisella
tularensis)
PF00162
(PGK)
3 GLU A 225
ILE A 298
ALA A 218
None
0.62A 4wnwB-4ehjA:
undetectable
4wnwB-4ehjA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewt PEPTIDASE,
M20/M25/M40 FAMILY


(Staphylococcus
aureus)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
3 GLU A  28
ILE A  60
ALA A 137
None
0.64A 4wnwB-4ewtA:
undetectable
4wnwB-4ewtA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmk POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 2


(Mus musculus)
PF07686
(V-set)
PF08205
(C2-set_2)
3 GLU A 234
ILE A 210
ALA A 151
None
0.64A 4wnwB-4fmkA:
undetectable
4wnwB-4fmkA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxb PUTATIVE CYTOCHROME
P450


(Streptomyces
coelicolor)
PF00067
(p450)
3 GLU A  91
ILE A 322
ALA A  75
None
0.65A 4wnwB-4fxbA:
29.6
4wnwB-4fxbA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnr CHEMOTAXIS PROTEIN
CHEY


(Vibrio cholerae)
PF00072
(Response_reg)
3 GLU A  36
ILE A  11
ALA A   6
None
0.45A 4wnwB-4hnrA:
undetectable
4wnwB-4hnrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE


(Solanum
lycopersicum)
PF00171
(Aldedh)
3 GLU A 119
ILE A 200
ALA A 173
None
0.63A 4wnwB-4i8qA:
undetectable
4wnwB-4i8qA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5i ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE


(Mycolicibacterium
smegmatis)
PF02668
(TauD)
3 GLU A 188
ILE A  44
ALA A 245
None
0.65A 4wnwB-4j5iA:
undetectable
4wnwB-4j5iA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5i ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE


(Mycolicibacterium
smegmatis)
PF02668
(TauD)
3 GLU A 188
ILE A 240
ALA A 245
None
0.40A 4wnwB-4j5iA:
undetectable
4wnwB-4j5iA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ld7 DIMETHYLALLYL
TRYPTOPHAN SYNTHASE


(Aspergillus
fischeri)
PF11991
(Trp_DMAT)
3 GLU A 344
ILE A 206
ALA A 268
None
0.64A 4wnwB-4ld7A:
undetectable
4wnwB-4ld7A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea)
PF00232
(Glyco_hydro_1)
3 GLU A 292
ILE A 202
ALA A 210
None
PEG  A 504 ( 4.4A)
None
0.63A 4wnwB-4mdpA:
undetectable
4wnwB-4mdpA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4u PUTATIVE ABC
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN


(Bordetella
bronchiseptica)
PF03480
(DctP)
3 GLU A 269
ILE A 212
ALA A 275
None
0.45A 4wnwB-4n4uA:
undetectable
4wnwB-4n4uA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzs BETA-KETOTHIOLASE
BKTB


(Cupriavidus
necator)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
3 GLU A   4
ILE A 390
ALA A 101
None
0.59A 4wnwB-4nzsA:
undetectable
4wnwB-4nzsA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS


(Desulfitobacterium
hafniense)
PF00809
(Pterin_bind)
3 GLU A 107
ILE A 140
ALA A 148
None
0.58A 4wnwB-4o1eA:
undetectable
4wnwB-4o1eA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofz TREHALOSE-PHOSPHATAS
E


(Brugia malayi)
no annotation 3 GLU A 386
ILE A 395
ALA A 389
None
0.64A 4wnwB-4ofzA:
undetectable
4wnwB-4ofzA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol9 PUTATIVE
2-DEHYDROPANTOATE
2-REDUCTASE


(Mycobacterium
tuberculosis)
PF02558
(ApbA)
PF08546
(ApbA_C)
3 GLU A 258
ILE A 121
ALA A  72
NAP  A 301 (-2.8A)
None
None
0.66A 4wnwB-4ol9A:
undetectable
4wnwB-4ol9A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4raa PUTATIVE EXPORTED
PROTEIN


(Bacteroides
fragilis)
PF17170
(DUF5128)
3 GLU A 145
ILE A 108
ALA A 124
None
0.51A 4wnwB-4raaA:
undetectable
4wnwB-4raaA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u30 TRYPSTATIN

(Homo sapiens)
no annotation 3 GLU X  50
ILE X  18
ALA X  22
None
0.66A 4wnwB-4u30X:
undetectable
4wnwB-4u30X:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0e PUTATIVE DIOXYGENASE

(Mycobacteroides
abscessus)
PF02668
(TauD)
3 GLU A 202
ILE A 254
ALA A 259
MPD  A 402 (-2.9A)
None
None
0.43A 4wnwB-4y0eA:
undetectable
4wnwB-4y0eA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG


(Cupriavidus
necator)
PF00374
(NiFeSe_Hases)
3 GLU C 261
ILE C 267
ALA C 543
None
0.62A 4wnwB-5aa5C:
undetectable
4wnwB-5aa5C:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6o HOMOSERINE
O-ACETYLTRANSFERASE


(Corynebacterium
glutamicum)
PF00561
(Abhydrolase_1)
3 GLU A 307
ILE A 115
ALA A 280
None
0.66A 4wnwB-5d6oA:
1.3
4wnwB-5d6oA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE


(Cryptococcus
neoformans)
PF02358
(Trehalose_PPase)
3 GLU A 249
ILE A 100
ALA A 105
None
0.64A 4wnwB-5dx9A:
undetectable
4wnwB-5dx9A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fic SPHINGOMYELIN
PHOSPHODIESTERASE


(Mus musculus)
PF00149
(Metallophos)
3 GLU A 460
ILE A 424
ALA A 477
None
0.65A 4wnwB-5ficA:
undetectable
4wnwB-5ficA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2


(Homo sapiens)
no annotation 3 GLU I 398
ILE I 377
ALA I 453
None
0.56A 4wnwB-5furI:
undetectable
4wnwB-5furI:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0i ASPARAGINYL
ENDOPEPTIDASE


(Oldenlandia
affinis)
PF01650
(Peptidase_C13)
3 GLU A 405
ILE A 457
ALA A 409
None
0.63A 4wnwB-5h0iA:
undetectable
4wnwB-5h0iA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE


(Mus musculus)
PF00149
(Metallophos)
3 GLU A 460
ILE A 424
ALA A 477
None
0.63A 4wnwB-5hqnA:
undetectable
4wnwB-5hqnA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvf CARBOXYPEPTIDASE B2

(Homo sapiens)
PF00246
(Peptidase_M14)
PF02244
(Propep_M14)
3 GLU A 266
ILE A 229
ALA A 160
None
0.59A 4wnwB-5hvfA:
undetectable
4wnwB-5hvfA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id6 CPF1

(Lachnospiraceae
bacterium
ND2006)
no annotation 3 GLU A1168
ILE A1072
ALA A1179
None
0.65A 4wnwB-5id6A:
undetectable
4wnwB-5id6A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1q CARBOXYPEPTIDASE B

(Sus scrofa)
PF00246
(Peptidase_M14)
3 GLU A 175
ILE A 139
ALA A  70
None
0.51A 4wnwB-5j1qA:
undetectable
4wnwB-5j1qA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3h ACYL-COENZYME A
OXIDASE


(Caenorhabditis
elegans)
PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N)
3 GLU A 360
ILE A 492
ALA A 353
None
0.64A 4wnwB-5k3hA:
undetectable
4wnwB-5k3hA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k94 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PROTEIN
TRANSLOCASE SUBUNIT
SECA,MALTOSE-BINDING
PERIPLASMIC PROTEIN


(Escherichia
coli)
PF01043
(SecA_PP_bind)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8)
3 GLU A 368
ILE A 335
ALA A 356
None
0.53A 4wnwB-5k94A:
undetectable
4wnwB-5k94A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdj F5/8 TYPE C DOMAIN
PROTEIN


(Clostridium
perfringens)
no annotation 3 GLU B 845
ILE B 861
ALA B 869
None
0.59A 4wnwB-5kdjB:
undetectable
4wnwB-5kdjB:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kds F5/8 TYPE C DOMAIN
PROTEIN


(Clostridium
perfringens)
PF13402
(Peptidase_M60)
3 GLU A 845
ILE A 861
ALA A 869
None
0.54A 4wnwB-5kdsA:
undetectable
4wnwB-5kdsA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msc CARBOXYLIC ACID
REDUCTASE


(Nocardia
iowensis)
PF00501
(AMP-binding)
3 GLU A  99
ILE A 126
ALA A 134
None
0.65A 4wnwB-5mscA:
undetectable
4wnwB-5mscA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n29 CTP SYNTHASE

(Trypanosoma
brucei)
PF00117
(GATase)
3 GLU A 370
ILE A 427
ALA A 404
None
0.66A 4wnwB-5n29A:
undetectable
4wnwB-5n29A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1)
no annotation 3 GLU A 361
ILE B 998
ALA A 358
None
0.53A 4wnwB-5nd1A:
undetectable
4wnwB-5nd1A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn6 TAURINE DIOXYGENASE

(Burkholderia
ambifaria)
PF02668
(TauD)
3 GLU A 187
ILE A 250
ALA A 255
None
0.47A 4wnwB-5vn6A:
undetectable
4wnwB-5vn6A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zby HYDROGENASE
MATURATION PROTEASE
HYCI


(Thermococcus
kodakarensis)
no annotation 3 GLU A 134
ILE A  82
ALA A  28
None
0.66A 4wnwB-5zbyA:
undetectable
4wnwB-5zbyA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4


(Mus musculus)
no annotation 3 GLU B 824
ILE B 897
ALA B 817
None
0.49A 4wnwB-6bcqB:
undetectable
4wnwB-6bcqB:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq6 THERMOSPERMINE
SYNTHASE


(Medicago
truncatula)
no annotation 3 GLU A 109
ILE A 248
ALA A  67
None
0.63A 4wnwB-6bq6A:
undetectable
4wnwB-6bq6A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cdd NPL4 ZINC FINGER

(Chaetomium
thermophilum)
no annotation 3 GLU A 513
ILE A 267
ALA A 274
None
0.59A 4wnwB-6cddA:
undetectable
4wnwB-6cddA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gdt -

(-)
no annotation 3 GLU A 442
ILE A 401
ALA A 475
None
0.50A 4wnwB-6gdtA:
undetectable
4wnwB-6gdtA:
undetectable