SIMILAR PATTERNS OF AMINO ACIDS FOR 4WNW_B_RTZB602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4s BETAINE ALDEHYDE
DEHYDROGENASE

(Gadus morhua) 		PF00171
(Aldedh) 		5 GLY A 225
ALA A  57
ASP A  61
VAL A 218
VAL A 158
 None
 1.13A 4wnwB-1a4sA:
undetectable		 4wnwB-1a4sA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8s CHLOROPEROXIDASE F

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		5 PHE A 205
PHE A 200
GLY A 134
LEU A 135
VAL A 139
 None
PPI  A 278 (-3.6A)
None
None
None
 1.09A 4wnwB-1a8sA:
0.0		 4wnwB-1a8sA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bnl COLLAGEN XVIII

(Homo sapiens) 		PF06482
(Endostatin) 		5 LEU A 172
GLY A 154
LEU A 153
ALA A 149
VAL A 108
 None
 1.10A 4wnwB-1bnlA:
undetectable		 4wnwB-1bnlA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek2 EPOXIDE HYDROLASE

(Mus musculus) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		5 PHE A 458
LEU A 462
GLY A 426
LEU A 428
ALA A 393
 None
 1.12A 4wnwB-1ek2A:
0.0		 4wnwB-1ek2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 274
GLY A 288
LEU A 292
VAL A 415
VAL A 298
 None
 0.99A 4wnwB-1k9aA:
0.0		 4wnwB-1k9aA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 LEU A 580
GLY A 738
LEU A 737
ALA A 759
PHE A 746
 None
 1.03A 4wnwB-1ofeA:
0.0		 4wnwB-1ofeA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og0 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Saccharomyces
cerevisiae) 		PF00793
(DAHP_synth_1) 		5 LEU A 186
GLY A 193
LEU A 194
ALA A 217
VAL A 198
 None
None
PHE  A1012 (-4.2A)
None
None
 1.09A 4wnwB-1og0A:
0.0		 4wnwB-1og0A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE

(Saccharomyces
cerevisiae) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A 374
LEU A 373
GLN A 275
ALA A 208
SER A 211
 None
 1.01A 4wnwB-1pxtA:
0.0		 4wnwB-1pxtA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1toa PROTEIN (PERIPLASMIC
BINDING PROTEIN
TROA)

(Treponema
pallidum) 		PF01297
(ZnuA) 		5 GLY A  90
LEU A  91
ALA A 147
VAL A 134
PHE A 130
 None
 1.10A 4wnwB-1toaA:
0.0		 4wnwB-1toaA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us2 ENDO-BETA-1,4-XYLANA
SE

(Cellvibrio
japonicus) 		PF00331
(Glyco_hydro_10)
PF03426
(CBM_15) 		5 PHE A 465
GLY A 490
LEU A 489
GLN A 545
VAL A 450
 None
 1.10A 4wnwB-1us2A:
undetectable		 4wnwB-1us2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG

(Homo sapiens) 		PF08423
(Rad51) 		5 PHE A 265
GLY A 114
LEU A 112
ALA A 263
PHE A 108
 None
 0.99A 4wnwB-1v5wA:
undetectable		 4wnwB-1v5wA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9c PRECORRIN-8X METHYL
MUTASE

(Thermus
thermophilus) 		PF02570
(CbiC) 		5 GLY A  79
LEU A  80
ALA A  73
ASP A  72
VAL A  92
 None
 0.90A 4wnwB-1v9cA:
undetectable		 4wnwB-1v9cA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp5 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE

(Thermotoga
maritima) 		PF00248
(Aldo_ket_red) 		5 PHE A  22
LEU A 284
GLN A 113
ALA A  47
SER A  49
 NAP  A 300 (-4.5A)
None
NAP  A 300 ( 4.3A)
None
None
 1.06A 4wnwB-1vp5A:
undetectable		 4wnwB-1vp5A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7l HYPOTHETICAL
UBIQUITIN-CONJUGATIN
G ENZYME LOC55284

(Homo sapiens) 		PF00179
(UQ_con) 		5 PHE A  73
LEU A  95
GLN A  70
VAL A 108
VAL A  84
 None
 1.11A 4wnwB-2a7lA:
undetectable		 4wnwB-2a7lA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az4 HYPOTHETICAL PROTEIN
EF2904

(Enterococcus
faecalis) 		PF12706
(Lactamase_B_2) 		5 LEU A 212
GLY A 188
ALA A 207
VAL A  25
PHE A  34
 None
 1.09A 4wnwB-2az4A:
undetectable		 4wnwB-2az4A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5o FERREDOXIN--NADP
REDUCTASE

(Synechococcus
sp. PCC 7002) 		PF00175
(NAD_binding_1) 		5 PHE A 304
PHE A 268
GLY A 361
ALA A 184
VAL A 253
 None
 1.01A 4wnwB-2b5oA:
undetectable		 4wnwB-2b5oA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1p HYPOTHETICAL UPF0163
PROTEIN YHEN

(Escherichia
coli) 		PF02635
(DrsE) 		6 PHE A  58
LEU A  60
LEU A  34
GLN A  25
VAL A  73
VAL A   7
 None
 1.48A 4wnwB-2d1pA:
undetectable		 4wnwB-2d1pA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t 3-KETOACYL-COA
THIOLASE

(Pseudomonas
fragi) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY C 346
LEU C 345
GLN C 244
ALA C 173
SER C 176
 None
 0.94A 4wnwB-2d3tC:
undetectable		 4wnwB-2d3tC:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmg KIAA1228 PROTEIN

(Homo sapiens) 		PF00168
(C2) 		5 GLY A  11
LEU A 133
ALA A  32
VAL A  97
VAL A 116
 None
 1.12A 4wnwB-2dmgA:
undetectable		 4wnwB-2dmgA:
16.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		6 PHE A 112
PHE A 120
GLY A 212
LEU A 213
ASP A 301
VAL A 308
 None
HEM  A 600 (-4.6A)
None
None
None
None
 1.10A 4wnwB-2f9qA:
51.5		 4wnwB-2f9qA:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		6 PHE A 112
PHE A 120
GLY A 212
LEU A 213
GLN A 244
VAL A 308
 None
HEM  A 600 (-4.6A)
None
None
None
None
 1.36A 4wnwB-2f9qA:
51.5		 4wnwB-2f9qA:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		7 PHE A 112
PHE A 120
LEU A 121
GLY A 212
ALA A 300
ASP A 301
SER A 304
 None
HEM  A 600 (-4.6A)
None
None
None
None
None
 0.73A 4wnwB-2f9qA:
51.5		 4wnwB-2f9qA:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		6 PHE A 112
PHE A 120
LEU A 121
GLY A 212
ASP A 301
VAL A 308
 None
HEM  A 600 (-4.6A)
None
None
None
None
 0.91A 4wnwB-2f9qA:
51.5		 4wnwB-2f9qA:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		6 PHE A 112
PHE A 120
LEU A 121
GLY A 212
GLN A 244
VAL A 308
 None
HEM  A 600 (-4.6A)
None
None
None
None
 1.27A 4wnwB-2f9qA:
51.5		 4wnwB-2f9qA:
99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf0 BILE SALT HYDROLASE

(Bifidobacterium
longum) 		PF02275
(CBAH) 		5 GLY A   3
LEU A 170
SER A 150
VAL A 152
PHE A 226
 None
 1.08A 4wnwB-2hf0A:
undetectable		 4wnwB-2hf0A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5g AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		5 LEU A 298
GLY A 210
ALA A 232
VAL A 240
VAL A 307
 None
 1.09A 4wnwB-2i5gA:
undetectable		 4wnwB-2i5gA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kig INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE II
ISOFORM

(Mus musculus) 		PF16776
(INPP5B_PH) 		5 LEU A 127
GLY A  42
ALA A 133
VAL A  78
VAL A 104
 None
 1.08A 4wnwB-2kigA:
undetectable		 4wnwB-2kigA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kua BCL-2-LIKE PROTEIN
10

(Mus musculus) 		PF00452
(Bcl-2) 		5 PHE A 158
LEU A  41
GLY A 149
LEU A 148
VAL A  91
 None
 1.12A 4wnwB-2kuaA:
undetectable		 4wnwB-2kuaA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nv0 GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Bacillus
subtilis) 		PF01174
(SNO) 		5 PHE A 169
GLY A  81
ALA A 136
VAL A 179
PHE A  76
 None
 1.07A 4wnwB-2nv0A:
undetectable		 4wnwB-2nv0A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides) 		PF02614
(UxaC) 		5 PHE A 121
PHE A 108
LEU A 117
LEU A  81
VAL A  76
 None
 1.07A 4wnwB-2q01A:
0.7		 4wnwB-2q01A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7y CHAPERONE PROTEIN
DNAK

(Geobacillus
kaustophilus) 		PF00012
(HSP70) 		5 LEU A 164
GLY A 310
LEU A 168
VAL A 289
PHE A 173
 None
ADP  A1505 (-3.1A)
None
None
None
 1.05A 4wnwB-2v7yA:
undetectable		 4wnwB-2v7yA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 PHE A 401
GLY A 234
LEU A 235
ALA A 248
SER A 250
 None
 1.11A 4wnwB-2wdaA:
undetectable		 4wnwB-2wdaA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we8 XANTHINE
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF02625
(XdhC_CoxI)
PF13478
(XdhC_C) 		5 PHE A 111
GLY A  10
LEU A   9
ALA A  22
VAL A   5
 None
 0.98A 4wnwB-2we8A:
undetectable		 4wnwB-2we8A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfq NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Peptoniphilus
asaccharolyticus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 GLY A  96
LEU A  98
ASP A 344
VAL A 352
VAL A 198
 None
None
None
SO4  A1422 (-3.7A)
None
 1.01A 4wnwB-2yfqA:
undetectable		 4wnwB-2yfqA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbl PUTATIVE ISOMERASE

(Salmonella
enterica) 		PF07221
(GlcNAc_2-epim) 		5 GLY A 398
LEU A 399
ALA A 121
SER A 122
VAL A  62
 None
 0.96A 4wnwB-2zblA:
undetectable		 4wnwB-2zblA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3j PBP5

(Haemophilus
influenzae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 LEU A  66
GLY A 218
LEU A 219
VAL A 227
VAL A 257
 None
 1.10A 4wnwB-3a3jA:
undetectable		 4wnwB-3a3jA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bma D-ALANYL-LIPOTEICHOI
C ACID SYNTHETASE

(Streptococcus
pneumoniae) 		PF04914
(DltD) 		5 GLY A 384
LEU A 386
ALA A 261
ASP A 260
VAL A  90
 None
 1.02A 4wnwB-3bmaA:
undetectable		 4wnwB-3bmaA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOA
PMOB

(Methylosinus
trichosporium) 		PF02461
(AMO)
PF04744
(Monooxygenase_B) 		5 PHE A 214
PHE B  30
LEU B  31
ALA A 221
PHE B  83
 None
 1.11A 4wnwB-3chxA:
undetectable		 4wnwB-3chxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOA
PMOB

(Methylosinus
trichosporium) 		PF02461
(AMO)
PF04744
(Monooxygenase_B) 		5 PHE B  30
LEU B  31
ALA A 221
ASP B  27
PHE B  83
 None
 1.12A 4wnwB-3chxB:
undetectable		 4wnwB-3chxB:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 274
GLY A 288
LEU A 292
VAL A 415
VAL A 298
 None
 0.99A 4wnwB-3d7uA:
undetectable		 4wnwB-3d7uA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfm 146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR

(Sulfurisphaera
tokodaii) 		PF13463
(HTH_27) 		5 LEU A  56
GLN A  64
ALA A  69
ASP A  72
VAL A  42
 None
 0.93A 4wnwB-3gfmA:
undetectable		 4wnwB-3gfmA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi8 UNCHARACTERIZED
PROTEIN MJ0609

(Methanocaldococcus
jannaschii) 		PF13520
(AA_permease_2) 		5 PHE C 204
GLY C  19
ALA C 224
SER C 228
VAL C 232
 None
 1.02A 4wnwB-3gi8C:
0.4		 4wnwB-3gi8C:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 PHE A 256
GLY A 250
GLN A   3
VAL A  93
VAL A 286
 None
 1.02A 4wnwB-3h2xA:
undetectable		 4wnwB-3h2xA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		5 PHE A 280
LEU A 225
LEU A 288
ASP A 278
PHE A 247
 None
 1.00A 4wnwB-3h39A:
undetectable		 4wnwB-3h39A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hu5 ISOCHORISMATASE
FAMILY PROTEIN

(Desulfovibrio
vulgaris) 		PF00857
(Isochorismatase) 		5 GLY A  41
LEU A  42
ASP A 190
VAL A 157
VAL A   9
 None
 0.97A 4wnwB-3hu5A:
undetectable		 4wnwB-3hu5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00476
(DNA_pol_A) 		5 LEU A 428
LEU A 411
ALA A 847
SER A 296
VAL A 266
 None
 1.04A 4wnwB-3ikmA:
undetectable		 4wnwB-3ikmA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1d 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 LEU A 354
GLY A 131
LEU A 130
VAL A 183
VAL A 388
 None
 0.99A 4wnwB-3k1dA:
undetectable		 4wnwB-3k1dA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		5 GLY A   6
LEU A   7
ALA A  34
VAL A  10
VAL A 424
 None
 1.13A 4wnwB-3lscA:
undetectable		 4wnwB-3lscA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF13378
(MR_MLE_C) 		5 PHE A 116
GLY A 124
LEU A 123
ALA A 128
VAL A  75
 None
 1.04A 4wnwB-3mznA:
undetectable		 4wnwB-3mznA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ono RIBOSE/GALACTOSE
ISOMERASE

(Vibrio
parahaemolyticus) 		PF02502
(LacAB_rpiB)
PF12408
(DUF3666) 		5 PHE A 114
LEU A 112
ALA A  77
VAL A  87
PHE A  66
 None
 1.12A 4wnwB-3onoA:
undetectable		 4wnwB-3onoA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1t ENOYL-COA HYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 GLY A 122
ALA A  98
VAL A  39
VAL A  65
PHE A  72
 None
 1.06A 4wnwB-3q1tA:
undetectable		 4wnwB-3q1tA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk8 ENOYL-COA HYDRATASE
ECHA15

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		6 LEU A  99
GLY A 116
ALA A  92
VAL A  33
VAL A  59
PHE A  66
 None
 1.23A 4wnwB-3qk8A:
undetectable		 4wnwB-3qk8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rsc CALG2

(Micromonospora
echinospora) 		PF04101
(Glyco_tran_28_C) 		5 PHE A 245
GLY A 303
LEU A 307
VAL A 333
VAL A 297
 None
TYD  A 397 (-3.4A)
None
None
None
 1.06A 4wnwB-3rscA:
undetectable		 4wnwB-3rscA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6p CAPSID PROTEIN

(Helicoverpa
armigera stunt
virus) 		PF03566
(Peptidase_A21) 		5 PHE A 366
LEU A 353
VAL A 400
VAL A 373
PHE A 375
 None
 1.11A 4wnwB-3s6pA:
undetectable		 4wnwB-3s6pA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT

(uncultured
archaeon) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 LEU A 115
GLY A 122
LEU A 124
VAL A 132
VAL A 245
 None
 1.06A 4wnwB-3sqgA:
0.0		 4wnwB-3sqgA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4w MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Sulfitobacter
sp. NAS-14.1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 367
GLY A 285
LEU A 284
ALA A 100
ASP A 103
 None
 0.84A 4wnwB-3t4wA:
undetectable		 4wnwB-3t4wA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0f ENDONUCLEASE 8-LIKE
3

(Mus musculus) 		PF06831
(H2TH) 		5 PHE A  69
LEU A  66
GLY A  29
LEU A 120
VAL A 136
 None
 1.01A 4wnwB-3w0fA:
undetectable		 4wnwB-3w0fA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3s TYPE-2 SERINE--TRNA
LIGASE

(Methanopyrus
kandleri) 		PF00587
(tRNA-synt_2b) 		5 PHE A 242
GLY A 451
ALA A 388
VAL A 402
VAL A 455
 None
SSA  A2002 (-3.4A)
None
None
None
 1.13A 4wnwB-3w3sA:
undetectable		 4wnwB-3w3sA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjk BETA GLYCOSIDASE

(Thermus
thermophilus) 		PF00232
(Glyco_hydro_1) 		5 PHE A 391
PHE A 395
GLY A 172
LEU A 171
ALA A  42
 None
 1.09A 4wnwB-3zjkA:
undetectable		 4wnwB-3zjkA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Mycobacterium
tuberculosis) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 GLY A 478
LEU A 482
ALA A 471
ASP A 470
VAL A 490
 None
None
None
K  A1524 (-3.6A)
None
 0.94A 4wnwB-4a1oA:
undetectable		 4wnwB-4a1oA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Mycobacterium
tuberculosis) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 GLY A 478
LEU A 482
ASP A 470
VAL A 490
VAL A 440
 None
None
K  A1524 (-3.6A)
None
None
 1.06A 4wnwB-4a1oA:
undetectable		 4wnwB-4a1oA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aal CYTOCHROME C551
PEROXIDASE

(Geobacter
sulfurreducens) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		5 LEU A  65
GLY A 153
SER A 150
VAL A 174
PHE A 158
 None
 1.05A 4wnwB-4aalA:
undetectable		 4wnwB-4aalA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkm PYRIDOXAL PHOSPHATE
PHOSPHATASE,
PHOSPHOGLYCOLATE
PHOSPHATASE,
PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 PHE A  77
LEU A  44
GLY A 246
SER A 295
VAL A 293
 None
 1.11A 4wnwB-4bkmA:
undetectable		 4wnwB-4bkmA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di1 ENOYL-COA HYDRATASE
ECHA17

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 GLY A  42
LEU A  41
ALA A  91
VAL A  50
VAL A   5
 None
 0.84A 4wnwB-4di1A:
undetectable		 4wnwB-4di1A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		5 PHE A 223
LEU A 224
GLY A 210
LEU A 209
VAL A 316
 None
 1.11A 4wnwB-4fdhA:
34.9		 4wnwB-4fdhA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE

(Caenorhabditis
elegans) 		PF03372
(Exo_endo_phos) 		5 PHE A 267
LEU A 228
GLY A 222
ALA A 264
VAL A 122
 None
 0.95A 4wnwB-4fvaA:
undetectable		 4wnwB-4fvaA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g81 PUTATIVE HEXONATE
DEHYDROGENASE

(Salmonella
enterica) 		no annotation 5 GLY D  63
ALA D  27
SER D  18
VAL D 125
PHE D  66
 None
 1.04A 4wnwB-4g81D:
undetectable		 4wnwB-4g81D:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE

(Caenorhabditis
elegans) 		PF03372
(Exo_endo_phos)
PF14555
(UBA_4) 		5 PHE A 267
LEU A 228
GLY A 222
ALA A 264
VAL A 122
 None
 0.98A 4wnwB-4gewA:
undetectable		 4wnwB-4gewA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrb GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria;
Blattella
germanica) 		PF01353
(GFP)
PF06757
(Ins_allergen_rp) 		5 PHE A1043
LEU A1044
GLY A1102
LEU A1036
GLN A1037
 D12  A1304 ( 4.1A)
None
None
None
None
 1.09A 4wnwB-4jrbA:
undetectable		 4wnwB-4jrbA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3y NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU A 254
LEU A 192
GLN A 226
ALA A 242
VAL A 203
 None
 1.07A 4wnwB-4k3yA:
undetectable		 4wnwB-4k3yA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le6 ORGANOPHOSPHORUS
HYDROLASE

(Pseudomonas
pseudoalcaligenes) 		PF00753
(Lactamase_B) 		5 GLY A 116
LEU A 115
ALA A  91
ASP A 104
PHE A 111
 GOL  A 401 (-3.6A)
None
None
None
GOL  A 402 (-3.8A)
 1.05A 4wnwB-4le6A:
undetectable		 4wnwB-4le6A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		5 PHE A 250
LEU A 231
LEU A 235
ALA A 103
VAL A  80
 None
 1.01A 4wnwB-4my5A:
undetectable		 4wnwB-4my5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuh ICE-BINDING PROTEIN

(Leucosporidium) 		PF11999
(DUF3494) 		5 PHE A 128
LEU A 154
LEU A 146
VAL A 122
PHE A 179
 None
 1.09A 4wnwB-4nuhA:
undetectable		 4wnwB-4nuhA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6d NS1

(West Nile virus) 		PF00948
(Flavi_NS1) 		6 PHE B 277
LEU B 321
GLY B 249
LEU B 247
ALA B 215
VAL B 220
 None
 1.30A 4wnwB-4o6dB:
undetectable		 4wnwB-4o6dB:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oie NON-STRUCTURAL
PROTEIN NS1

(West Nile virus) 		PF00948
(Flavi_NS1) 		5 PHE A 277
LEU A 321
GLY A 249
LEU A 247
VAL A 220
 None
 1.09A 4wnwB-4oieA:
undetectable		 4wnwB-4oieA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okd ISOAMYLASE

(Chlamydomonas
reinhardtii) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 PHE A 823
GLY A 785
LEU A 778
ALA A 740
PHE A 776
 None
 1.11A 4wnwB-4okdA:
undetectable		 4wnwB-4okdA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4olq ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Hyphomonas
neptunium) 		PF00378
(ECH_1) 		5 GLY A 178
LEU A 177
ALA A 152
VAL A 133
PHE A 169
 None
 1.05A 4wnwB-4olqA:
undetectable		 4wnwB-4olqA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Alicyclobacillus
acidocaldarius) 		PF13416
(SBP_bac_8) 		5 GLY A 312
LEU A 313
GLN A 217
VAL A 388
VAL A 164
 None
 1.10A 4wnwB-4ovjA:
undetectable		 4wnwB-4ovjA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pls ARM00010

(synthetic
construct) 		PF00514
(Arm) 		5 LEU A 188
GLY A 162
LEU A 161
ALA A 207
VAL A 175
 None
 1.10A 4wnwB-4plsA:
undetectable		 4wnwB-4plsA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt5 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Planctopirus
limnophila) 		PF00903
(Glyoxalase) 		5 PHE A  53
LEU A  56
LEU A  60
ALA A  42
VAL A  30
 None
 1.10A 4wnwB-4rt5A:
undetectable		 4wnwB-4rt5A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLY A3716
LEU A3717
ALA A3646
VAL A3719
PHE A3693
 None
 1.05A 4wnwB-4tktA:
undetectable		 4wnwB-4tktA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		5 PHE A 113
LEU A   9
LEU A  30
ALA A 110
VAL A 156
 SAH  A 301 (-4.9A)
None
None
None
None
 1.10A 4wnwB-4xboA:
undetectable		 4wnwB-4xboA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuk PUTATIVE HYDROLASE

(Acinetobacter
sp. NBRC 100985) 		PF00753
(Lactamase_B) 		5 GLY A 132
LEU A 131
ALA A 107
ASP A 120
PHE A 127
 None
 1.00A 4wnwB-4xukA:
undetectable		 4wnwB-4xukA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cv1 P GRANULE
ABNORMALITY PROTEIN
1

(Caenorhabditis
elegans) 		no annotation 5 PHE A 469
GLY A 353
LEU A 352
VAL A 375
VAL A 479
 None
 0.94A 4wnwB-5cv1A:
undetectable		 4wnwB-5cv1A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cw0 COAT PROTEIN

(Panicum
papanivirus 1) 		no annotation 5 PHE A  39
LEU A 123
GLY A 127
LEU A  31
VAL A 143
 None
 1.11A 4wnwB-5cw0A:
undetectable		 4wnwB-5cw0A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD

(Escherichia
coli) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 LEU A  43
GLY A 198
LEU A 199
VAL A 207
VAL A 236
 None
 1.00A 4wnwB-5fsrA:
undetectable		 4wnwB-5fsrA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g6r IMINE REDUCTASE

(Aspergillus
oryzae) 		PF03446
(NAD_binding_2) 		5 GLY A 117
LEU A 133
ALA A 162
ASP A 161
SER A 135
 None
 0.88A 4wnwB-5g6rA:
undetectable		 4wnwB-5g6rA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ie2 OXALATE--COA LIGASE

(Arabidopsis
thaliana) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A  36
GLY A   8
LEU A   6
VAL A 191
VAL A  70
 None
 1.00A 4wnwB-5ie2A:
undetectable		 4wnwB-5ie2A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojl IMINE REDUCTASE

(Aspergillus
terreus) 		no annotation 5 GLY A 122
LEU A 138
ALA A 168
ASP A 167
SER A 140
 None
 0.88A 4wnwB-5ojlA:
undetectable		 4wnwB-5ojlA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcb PELA

(Pseudomonas
aeruginosa) 		PF03537
(Glyco_hydro_114) 		5 LEU A 162
ALA A 179
VAL A  99
VAL A 211
PHE A 198
 None
 0.88A 4wnwB-5tcbA:
undetectable		 4wnwB-5tcbA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tky PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		5 LEU A 200
GLY A 342
LEU A 204
VAL A 321
PHE A 209
 None
ATP  A 700 (-3.3A)
None
None
None
 1.13A 4wnwB-5tkyA:
0.0		 4wnwB-5tkyA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tv2 ELONGATION FACTOR G

(Vibrio
vulnificus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		5 GLY A 385
LEU A 386
ALA A 323
VAL A 389
PHE A 358
 None
 1.01A 4wnwB-5tv2A:
undetectable		 4wnwB-5tv2A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7s FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Acinetobacter
baumannii) 		PF01116
(F_bP_aldolase) 		5 LEU A 229
GLY A 195
LEU A 212
SER A 234
VAL A 258
 None
 0.97A 4wnwB-5u7sA:
undetectable		 4wnwB-5u7sA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vre PUTATIVE INTEGRAL
MEMBRANE PROTEIN

(Chamaesiphon
minutus) 		PF06736
(DUF1211) 		5 GLY A  92
LEU A  94
ASP A  18
VAL A  98
PHE A 135
 None
 1.06A 4wnwB-5vreA:
0.2		 4wnwB-5vreA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 PHE A  74
GLY A 340
LEU A 341
VAL A 248
PHE A 258
 None
 1.06A 4wnwB-5weoA:
0.0		 4wnwB-5weoA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbk IMPORTIN-4

(Homo sapiens) 		no annotation 5 LEU D 904
GLY D 890
LEU D 889
ALA D 934
PHE D 855
 None
 1.11A 4wnwB-5xbkD:
undetectable		 4wnwB-5xbkD:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xkl ESX-3
SECRETION-ASSOCIATED
PROTEIN ESPG3

(Mycobacterium
tuberculosis) 		no annotation 5 GLY A 229
ALA A 171
ASP A 174
VAL A 242
VAL A  89
 None
 1.04A 4wnwB-5xklA:
undetectable		 4wnwB-5xklA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykb TREHALOSE SYNTHASE

(Deinococcus
radiodurans) 		no annotation 5 PHE A 197
GLY A  79
LEU A  78
VAL A  19
VAL A  68
 None
 1.07A 4wnwB-5ykbA:
undetectable		 4wnwB-5ykbA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ynl ARGINASE

(Glaciozyma
antarctica) 		no annotation 5 LEU A 131
GLY A 189
LEU A 190
ALA A 226
VAL A 156
 None
 0.90A 4wnwB-5ynlA:
undetectable		 4wnwB-5ynlA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoe 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Cricetulus
griseus) 		no annotation 5 LEU A 221
GLY A 363
LEU A 225
VAL A 342
PHE A 230
 None
ADP  A 603 (-3.6A)
None
None
None
 1.07A 4wnwB-6eoeA:
undetectable		 4wnwB-6eoeA:
21.96