SIMILAR PATTERNS OF AMINO ACIDS FOR 4WNW_B_RTZB602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a4s BETAINE ALDEHYDE
DEHYDROGENASE

(Gadus morhua) 		PF00171
(Aldedh) 		5 GLY A 225
ALA A  57
ASP A  61
VAL A 218
VAL A 158
 None
 1.13A 4wnwB-1a4sA:
undetectable		 4wnwB-1a4sA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8s CHLOROPEROXIDASE F

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		5 PHE A 205
PHE A 200
GLY A 134
LEU A 135
VAL A 139
 None
PPI  A 278 (-3.6A)
None
None
None
 1.09A 4wnwB-1a8sA:
0.0		 4wnwB-1a8sA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bnl COLLAGEN XVIII

(Homo sapiens) 		PF06482
(Endostatin) 		5 LEU A 172
GLY A 154
LEU A 153
ALA A 149
VAL A 108
 None
 1.10A 4wnwB-1bnlA:
undetectable		 4wnwB-1bnlA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ek2 EPOXIDE HYDROLASE

(Mus musculus) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		5 PHE A 458
LEU A 462
GLY A 426
LEU A 428
ALA A 393
 None
 1.12A 4wnwB-1ek2A:
0.0		 4wnwB-1ek2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 274
GLY A 288
LEU A 292
VAL A 415
VAL A 298
 None
 0.99A 4wnwB-1k9aA:
0.0		 4wnwB-1k9aA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 LEU A 580
GLY A 738
LEU A 737
ALA A 759
PHE A 746
 None
 1.03A 4wnwB-1ofeA:
0.0		 4wnwB-1ofeA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og0 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Saccharomyces
cerevisiae) 		PF00793
(DAHP_synth_1) 		5 LEU A 186
GLY A 193
LEU A 194
ALA A 217
VAL A 198
 None
None
PHE  A1012 (-4.2A)
None
None
 1.09A 4wnwB-1og0A:
0.0		 4wnwB-1og0A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE

(Saccharomyces
cerevisiae) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A 374
LEU A 373
GLN A 275
ALA A 208
SER A 211
 None
 1.01A 4wnwB-1pxtA:
0.0		 4wnwB-1pxtA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1toa PROTEIN (PERIPLASMIC
BINDING PROTEIN
TROA)

(Treponema
pallidum) 		PF01297
(ZnuA) 		5 GLY A  90
LEU A  91
ALA A 147
VAL A 134
PHE A 130
 None
 1.10A 4wnwB-1toaA:
0.0		 4wnwB-1toaA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1us2 ENDO-BETA-1,4-XYLANA
SE

(Cellvibrio
japonicus) 		PF00331
(Glyco_hydro_10)
PF03426
(CBM_15) 		5 PHE A 465
GLY A 490
LEU A 489
GLN A 545
VAL A 450
 None
 1.10A 4wnwB-1us2A:
undetectable		 4wnwB-1us2A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5w MEIOTIC
RECOMBINATION
PROTEIN DMC1/LIM15
HOMOLOG

(Homo sapiens) 		PF08423
(Rad51) 		5 PHE A 265
GLY A 114
LEU A 112
ALA A 263
PHE A 108
 None
 0.99A 4wnwB-1v5wA:
undetectable		 4wnwB-1v5wA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9c PRECORRIN-8X METHYL
MUTASE

(Thermus
thermophilus) 		PF02570
(CbiC) 		5 GLY A  79
LEU A  80
ALA A  73
ASP A  72
VAL A  92
 None
 0.90A 4wnwB-1v9cA:
undetectable		 4wnwB-1v9cA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vp5 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE

(Thermotoga
maritima) 		PF00248
(Aldo_ket_red) 		5 PHE A  22
LEU A 284
GLN A 113
ALA A  47
SER A  49
 NAP  A 300 (-4.5A)
None
NAP  A 300 ( 4.3A)
None
None
 1.06A 4wnwB-1vp5A:
undetectable		 4wnwB-1vp5A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a7l HYPOTHETICAL
UBIQUITIN-CONJUGATIN
G ENZYME LOC55284

(Homo sapiens) 		PF00179
(UQ_con) 		5 PHE A  73
LEU A  95
GLN A  70
VAL A 108
VAL A  84
 None
 1.11A 4wnwB-2a7lA:
undetectable		 4wnwB-2a7lA:
14.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az4 HYPOTHETICAL PROTEIN
EF2904

(Enterococcus
faecalis) 		PF12706
(Lactamase_B_2) 		5 LEU A 212
GLY A 188
ALA A 207
VAL A  25
PHE A  34
 None
 1.09A 4wnwB-2az4A:
undetectable		 4wnwB-2az4A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5o FERREDOXIN--NADP
REDUCTASE

(Synechococcus
sp. PCC 7002) 		PF00175
(NAD_binding_1) 		5 PHE A 304
PHE A 268
GLY A 361
ALA A 184
VAL A 253
 None
 1.01A 4wnwB-2b5oA:
undetectable		 4wnwB-2b5oA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1p HYPOTHETICAL UPF0163
PROTEIN YHEN

(Escherichia
coli) 		PF02635
(DrsE) 		6 PHE A  58
LEU A  60
LEU A  34
GLN A  25
VAL A  73
VAL A   7
 None
 1.48A 4wnwB-2d1pA:
undetectable		 4wnwB-2d1pA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t 3-KETOACYL-COA
THIOLASE

(Pseudomonas
fragi) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY C 346
LEU C 345
GLN C 244
ALA C 173
SER C 176
 None
 0.94A 4wnwB-2d3tC:
undetectable		 4wnwB-2d3tC:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dmg KIAA1228 PROTEIN

(Homo sapiens) 		PF00168
(C2) 		5 GLY A  11
LEU A 133
ALA A  32
VAL A  97
VAL A 116
 None
 1.12A 4wnwB-2dmgA:
undetectable		 4wnwB-2dmgA:
16.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		6 PHE A 112
PHE A 120
GLY A 212
LEU A 213
ASP A 301
VAL A 308
 None
HEM  A 600 (-4.6A)
None
None
None
None
 1.10A 4wnwB-2f9qA:
51.5		 4wnwB-2f9qA:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		6 PHE A 112
PHE A 120
GLY A 212
LEU A 213
GLN A 244
VAL A 308
 None
HEM  A 600 (-4.6A)
None
None
None
None
 1.36A 4wnwB-2f9qA:
51.5		 4wnwB-2f9qA:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		7 PHE A 112
PHE A 120
LEU A 121
GLY A 212
ALA A 300
ASP A 301
SER A 304
 None
HEM  A 600 (-4.6A)
None
None
None
None
None
 0.73A 4wnwB-2f9qA:
51.5		 4wnwB-2f9qA:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		6 PHE A 112
PHE A 120
LEU A 121
GLY A 212
ASP A 301
VAL A 308
 None
HEM  A 600 (-4.6A)
None
None
None
None
 0.91A 4wnwB-2f9qA:
51.5		 4wnwB-2f9qA:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		6 PHE A 112
PHE A 120
LEU A 121
GLY A 212
GLN A 244
VAL A 308
 None
HEM  A 600 (-4.6A)
None
None
None
None
 1.27A 4wnwB-2f9qA:
51.5		 4wnwB-2f9qA:
99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf0 BILE SALT HYDROLASE

(Bifidobacterium
longum) 		PF02275
(CBAH) 		5 GLY A   3
LEU A 170
SER A 150
VAL A 152
PHE A 226
 None
 1.08A 4wnwB-2hf0A:
undetectable		 4wnwB-2hf0A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5g AMIDOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01244
(Peptidase_M19) 		5 LEU A 298
GLY A 210
ALA A 232
VAL A 240
VAL A 307
 None
 1.09A 4wnwB-2i5gA:
undetectable		 4wnwB-2i5gA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kig INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE II
ISOFORM

(Mus musculus) 		PF16776
(INPP5B_PH) 		5 LEU A 127
GLY A  42
ALA A 133
VAL A  78
VAL A 104
 None
 1.08A 4wnwB-2kigA:
undetectable		 4wnwB-2kigA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kua BCL-2-LIKE PROTEIN
10

(Mus musculus) 		PF00452
(Bcl-2) 		5 PHE A 158
LEU A  41
GLY A 149
LEU A 148
VAL A  91
 None
 1.12A 4wnwB-2kuaA:
undetectable		 4wnwB-2kuaA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nv0 GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Bacillus
subtilis) 		PF01174
(SNO) 		5 PHE A 169
GLY A  81
ALA A 136
VAL A 179
PHE A  76
 None
 1.07A 4wnwB-2nv0A:
undetectable		 4wnwB-2nv0A:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides) 		PF02614
(UxaC) 		5 PHE A 121
PHE A 108
LEU A 117
LEU A  81
VAL A  76
 None
 1.07A 4wnwB-2q01A:
0.7		 4wnwB-2q01A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7y CHAPERONE PROTEIN
DNAK

(Geobacillus
kaustophilus) 		PF00012
(HSP70) 		5 LEU A 164
GLY A 310
LEU A 168
VAL A 289
PHE A 173
 None
ADP  A1505 (-3.1A)
None
None
None
 1.05A 4wnwB-2v7yA:
undetectable		 4wnwB-2v7yA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 PHE A 401
GLY A 234
LEU A 235
ALA A 248
SER A 250
 None
 1.11A 4wnwB-2wdaA:
undetectable		 4wnwB-2wdaA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we8 XANTHINE
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF02625
(XdhC_CoxI)
PF13478
(XdhC_C) 		5 PHE A 111
GLY A  10
LEU A   9
ALA A  22
VAL A   5
 None
 0.98A 4wnwB-2we8A:
undetectable		 4wnwB-2we8A:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfq NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Peptoniphilus
asaccharolyticus) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 GLY A  96
LEU A  98
ASP A 344
VAL A 352
VAL A 198
 None
None
None
SO4  A1422 (-3.7A)
None
 1.01A 4wnwB-2yfqA:
undetectable		 4wnwB-2yfqA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbl PUTATIVE ISOMERASE

(Salmonella
enterica) 		PF07221
(GlcNAc_2-epim) 		5 GLY A 398
LEU A 399
ALA A 121
SER A 122
VAL A  62
 None
 0.96A 4wnwB-2zblA:
undetectable		 4wnwB-2zblA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3j PBP5

(Haemophilus
influenzae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 LEU A  66
GLY A 218
LEU A 219
VAL A 227
VAL A 257
 None
 1.10A 4wnwB-3a3jA:
undetectable		 4wnwB-3a3jA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bma D-ALANYL-LIPOTEICHOI
C ACID SYNTHETASE

(Streptococcus
pneumoniae) 		PF04914
(DltD) 		5 GLY A 384
LEU A 386
ALA A 261
ASP A 260
VAL A  90
 None
 1.02A 4wnwB-3bmaA:
undetectable		 4wnwB-3bmaA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOA
PMOB

(Methylosinus
trichosporium) 		PF02461
(AMO)
PF04744
(Monooxygenase_B) 		5 PHE A 214
PHE B  30
LEU B  31
ALA A 221
PHE B  83
 None
 1.11A 4wnwB-3chxA:
undetectable		 4wnwB-3chxA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOA
PMOB

(Methylosinus
trichosporium) 		PF02461
(AMO)
PF04744
(Monooxygenase_B) 		5 PHE B  30
LEU B  31
ALA A 221
ASP B  27
PHE B  83
 None
 1.12A 4wnwB-3chxB:
undetectable		 4wnwB-3chxB:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 274
GLY A 288
LEU A 292
VAL A 415
VAL A 298
 None
 0.99A 4wnwB-3d7uA:
undetectable		 4wnwB-3d7uA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfm 146AA LONG
HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR

(Sulfurisphaera
tokodaii) 		PF13463
(HTH_27) 		5 LEU A  56
GLN A  64
ALA A  69
ASP A  72
VAL A  42
 None
 0.93A 4wnwB-3gfmA:
undetectable		 4wnwB-3gfmA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi8 UNCHARACTERIZED
PROTEIN MJ0609

(Methanocaldococcus
jannaschii) 		PF13520
(AA_permease_2) 		5 PHE C 204
GLY C  19
ALA C 224
SER C 228
VAL C 232
 None
 1.02A 4wnwB-3gi8C:
0.4		 4wnwB-3gi8C:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2x TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 22

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 PHE A 256
GLY A 250
GLN A   3
VAL A  93
VAL A 286
 None
 1.02A 4wnwB-3h2xA:
undetectable		 4wnwB-3h2xA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		5 PHE A 280
LEU A 225
LEU A 288
ASP A 278
PHE A 247
 None
 1.00A 4wnwB-3h39A:
undetectable		 4wnwB-3h39A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hu5 ISOCHORISMATASE
FAMILY PROTEIN

(Desulfovibrio
vulgaris) 		PF00857
(Isochorismatase) 		5 GLY A  41
LEU A  42
ASP A 190
VAL A 157
VAL A   9
 None
 0.97A 4wnwB-3hu5A:
undetectable		 4wnwB-3hu5A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1

(Homo sapiens) 		PF00476
(DNA_pol_A) 		5 LEU A 428
LEU A 411
ALA A 847
SER A 296
VAL A 266
 None
 1.04A 4wnwB-3ikmA:
undetectable		 4wnwB-3ikmA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1d 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 LEU A 354
GLY A 131
LEU A 130
VAL A 183
VAL A 388
 None
 0.99A 4wnwB-3k1dA:
undetectable		 4wnwB-3k1dA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lsc TRIAZINE HYDROLASE

(Paenarthrobacter
aurescens) 		PF01979
(Amidohydro_1) 		5 GLY A   6
LEU A   7
ALA A  34
VAL A  10
VAL A 424
 None
 1.13A 4wnwB-3lscA:
undetectable		 4wnwB-3lscA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzn GLUCARATE
DEHYDRATASE

(Chromohalobacter
salexigens) 		PF13378
(MR_MLE_C) 		5 PHE A 116
GLY A 124
LEU A 123
ALA A 128
VAL A  75
 None
 1.04A 4wnwB-3mznA:
undetectable		 4wnwB-3mznA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ono RIBOSE/GALACTOSE
ISOMERASE

(Vibrio
parahaemolyticus) 		PF02502
(LacAB_rpiB)
PF12408
(DUF3666) 		5 PHE A 114
LEU A 112
ALA A  77
VAL A  87
PHE A  66
 None
 1.12A 4wnwB-3onoA:
undetectable		 4wnwB-3onoA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1t ENOYL-COA HYDRATASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 GLY A 122
ALA A  98
VAL A  39
VAL A  65
PHE A  72
 None
 1.06A 4wnwB-3q1tA:
undetectable		 4wnwB-3q1tA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk8 ENOYL-COA HYDRATASE
ECHA15

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		6 LEU A  99
GLY A 116
ALA A  92
VAL A  33
VAL A  59
PHE A  66
 None
 1.23A 4wnwB-3qk8A:
undetectable		 4wnwB-3qk8A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rsc CALG2

(Micromonospora
echinospora) 		PF04101
(Glyco_tran_28_C) 		5 PHE A 245
GLY A 303
LEU A 307
VAL A 333
VAL A 297
 None
TYD  A 397 (-3.4A)
None
None
None
 1.06A 4wnwB-3rscA:
undetectable		 4wnwB-3rscA:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6p CAPSID PROTEIN

(Helicoverpa
armigera stunt
virus) 		PF03566
(Peptidase_A21) 		5 PHE A 366
LEU A 353
VAL A 400
VAL A 373
PHE A 375
 None
 1.11A 4wnwB-3s6pA:
undetectable		 4wnwB-3s6pA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqg METHYL COENZYME M
REDUCTASE, ALPHA
SUBUNIT

(uncultured
archaeon) 		PF02249
(MCR_alpha)
PF02745
(MCR_alpha_N) 		5 LEU A 115
GLY A 122
LEU A 124
VAL A 132
VAL A 245
 None
 1.06A 4wnwB-3sqgA:
0.0		 4wnwB-3sqgA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t4w MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Sulfitobacter
sp. NAS-14.1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 367
GLY A 285
LEU A 284
ALA A 100
ASP A 103
 None
 0.84A 4wnwB-3t4wA:
undetectable		 4wnwB-3t4wA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0f ENDONUCLEASE 8-LIKE
3

(Mus musculus) 		PF06831
(H2TH) 		5 PHE A  69
LEU A  66
GLY A  29
LEU A 120
VAL A 136
 None
 1.01A 4wnwB-3w0fA:
undetectable		 4wnwB-3w0fA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w3s TYPE-2 SERINE--TRNA
LIGASE

(Methanopyrus
kandleri) 		PF00587
(tRNA-synt_2b) 		5 PHE A 242
GLY A 451
ALA A 388
VAL A 402
VAL A 455
 None
SSA  A2002 (-3.4A)
None
None
None
 1.13A 4wnwB-3w3sA:
undetectable		 4wnwB-3w3sA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjk BETA GLYCOSIDASE

(Thermus
thermophilus) 		PF00232
(Glyco_hydro_1) 		5 PHE A 391
PHE A 395
GLY A 172
LEU A 171
ALA A  42
 None
 1.09A 4wnwB-3zjkA:
undetectable		 4wnwB-3zjkA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Mycobacterium
tuberculosis) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 GLY A 478
LEU A 482
ALA A 471
ASP A 470
VAL A 490
 None
None
None
K  A1524 (-3.6A)
None
 0.94A 4wnwB-4a1oA:
undetectable		 4wnwB-4a1oA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Mycobacterium
tuberculosis) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		5 GLY A 478
LEU A 482
ASP A 470
VAL A 490
VAL A 440
 None
None
K  A1524 (-3.6A)
None
None
 1.06A 4wnwB-4a1oA:
undetectable		 4wnwB-4a1oA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aal CYTOCHROME C551
PEROXIDASE

(Geobacter
sulfurreducens) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		5 LEU A  65
GLY A 153
SER A 150
VAL A 174
PHE A 158
 None
 1.05A 4wnwB-4aalA:
undetectable		 4wnwB-4aalA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkm PYRIDOXAL PHOSPHATE
PHOSPHATASE,
PHOSPHOGLYCOLATE
PHOSPHATASE,
PYRIDOXAL PHOSPHATE
PHOSPHATASE

(Mus musculus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		5 PHE A  77
LEU A  44
GLY A 246
SER A 295
VAL A 293
 None
 1.11A 4wnwB-4bkmA:
undetectable		 4wnwB-4bkmA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di1 ENOYL-COA HYDRATASE
ECHA17

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 GLY A  42
LEU A  41
ALA A  91
VAL A  50
VAL A   5
 None
 0.84A 4wnwB-4di1A:
undetectable		 4wnwB-4di1A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdh CYTOCHROME P450
11B2, MITOCHONDRIAL

(Homo sapiens) 		PF00067
(p450) 		5 PHE A 223
LEU A 224
GLY A 210
LEU A 209
VAL A 316
 None
 1.11A 4wnwB-4fdhA:
34.9		 4wnwB-4fdhA:
27.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fva 5'-TYROSYL-DNA
PHOSPHODIESTERASE

(Caenorhabditis
elegans) 		PF03372
(Exo_endo_phos) 		5 PHE A 267
LEU A 228
GLY A 222
ALA A 264
VAL A 122
 None
 0.95A 4wnwB-4fvaA:
undetectable		 4wnwB-4fvaA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g81 PUTATIVE HEXONATE
DEHYDROGENASE

(Salmonella
enterica) 		no annotation 5 GLY D  63
ALA D  27
SER D  18
VAL D 125
PHE D  66
 None
 1.04A 4wnwB-4g81D:
undetectable		 4wnwB-4g81D:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gew 5'-TYROSYL-DNA
PHOSPHODIESTERASE

(Caenorhabditis
elegans) 		PF03372
(Exo_endo_phos)
PF14555
(UBA_4) 		5 PHE A 267
LEU A 228
GLY A 222
ALA A 264
VAL A 122
 None
 0.98A 4wnwB-4gewA:
undetectable		 4wnwB-4gewA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrb GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria;
Blattella
germanica) 		PF01353
(GFP)
PF06757
(Ins_allergen_rp) 		5 PHE A1043
LEU A1044
GLY A1102
LEU A1036
GLN A1037
 D12  A1304 ( 4.1A)
None
None
None
None
 1.09A 4wnwB-4jrbA:
undetectable		 4wnwB-4jrbA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3y NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 LEU A 254
LEU A 192
GLN A 226
ALA A 242
VAL A 203
 None
 1.07A 4wnwB-4k3yA:
undetectable		 4wnwB-4k3yA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le6 ORGANOPHOSPHORUS
HYDROLASE

(Pseudomonas
pseudoalcaligenes) 		PF00753
(Lactamase_B) 		5 GLY A 116
LEU A 115
ALA A  91
ASP A 104
PHE A 111
 GOL  A 401 (-3.6A)
None
None
None
GOL  A 402 (-3.8A)
 1.05A 4wnwB-4le6A:
undetectable		 4wnwB-4le6A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my5 PUTATIVE AMINO ACID
AMINOTRANSFERASE

(Streptococcus
mutans) 		PF00155
(Aminotran_1_2) 		5 PHE A 250
LEU A 231
LEU A 235
ALA A 103
VAL A  80
 None
 1.01A 4wnwB-4my5A:
undetectable		 4wnwB-4my5A:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuh ICE-BINDING PROTEIN

(Leucosporidium) 		PF11999
(DUF3494) 		5 PHE A 128
LEU A 154
LEU A 146
VAL A 122
PHE A 179
 None
 1.09A 4wnwB-4nuhA:
undetectable		 4wnwB-4nuhA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6d NS1

(West Nile virus) 		PF00948
(Flavi_NS1) 		6 PHE B 277
LEU B 321
GLY B 249
LEU B 247
ALA B 215
VAL B 220
 None
 1.30A 4wnwB-4o6dB:
undetectable		 4wnwB-4o6dB:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oie NON-STRUCTURAL
PROTEIN NS1

(West Nile virus) 		PF00948
(Flavi_NS1) 		5 PHE A 277
LEU A 321
GLY A 249
LEU A 247
VAL A 220
 None
 1.09A 4wnwB-4oieA:
undetectable		 4wnwB-4oieA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4okd ISOAMYLASE

(Chlamydomonas
reinhardtii) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		5 PHE A 823
GLY A 785
LEU A 778
ALA A 740
PHE A 776
 None
 1.11A 4wnwB-4okdA:
undetectable		 4wnwB-4okdA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4olq ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Hyphomonas
neptunium) 		PF00378
(ECH_1) 		5 GLY A 178
LEU A 177
ALA A 152
VAL A 133
PHE A 169
 None
 1.05A 4wnwB-4olqA:
undetectable		 4wnwB-4olqA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovj EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Alicyclobacillus
acidocaldarius) 		PF13416
(SBP_bac_8) 		5 GLY A 312
LEU A 313
GLN A 217
VAL A 388
VAL A 164
 None
 1.10A 4wnwB-4ovjA:
undetectable		 4wnwB-4ovjA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pls ARM00010

(synthetic
construct) 		PF00514
(Arm) 		5 LEU A 188
GLY A 162
LEU A 161
ALA A 207
VAL A 175
 None
 1.10A 4wnwB-4plsA:
undetectable		 4wnwB-4plsA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt5 GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Planctopirus
limnophila) 		PF00903
(Glyoxalase) 		5 PHE A  53
LEU A  56
LEU A  60
ALA A  42
VAL A  30
 None
 1.10A 4wnwB-4rt5A:
undetectable		 4wnwB-4rt5A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 GLY A3716
LEU A3717
ALA A3646
VAL A3719
PHE A3693
 None
 1.05A 4wnwB-4tktA:
undetectable		 4wnwB-4tktA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		5 PHE A 113
LEU A   9
LEU A  30
ALA A 110
VAL A 156
 SAH  A 301 (-4.9A)
None
None
None
None
 1.10A 4wnwB-4xboA:
undetectable		 4wnwB-4xboA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuk PUTATIVE HYDROLASE

(Acinetobacter
sp. NBRC 100985) 		PF00753
(Lactamase_B) 		5 GLY A 132
LEU A 131
ALA A 107
ASP A 120
PHE A 127
 None
 1.00A 4wnwB-4xukA:
undetectable		 4wnwB-4xukA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cv1 P GRANULE
ABNORMALITY PROTEIN
1

(Caenorhabditis
elegans) 		no annotation 5 PHE A 469
GLY A 353
LEU A 352
VAL A 375
VAL A 479
 None
 0.94A 4wnwB-5cv1A:
undetectable		 4wnwB-5cv1A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cw0 COAT PROTEIN

(Panicum
papanivirus 1) 		no annotation 5 PHE A  39
LEU A 123
GLY A 127
LEU A  31
VAL A 143
 None
 1.11A 4wnwB-5cw0A:
undetectable		 4wnwB-5cw0A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsr D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACD

(Escherichia
coli) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 LEU A  43
GLY A 198
LEU A 199
VAL A 207
VAL A 236
 None
 1.00A 4wnwB-5fsrA:
undetectable		 4wnwB-5fsrA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g6r IMINE REDUCTASE

(Aspergillus
oryzae) 		PF03446
(NAD_binding_2) 		5 GLY A 117
LEU A 133
ALA A 162
ASP A 161
SER A 135
 None
 0.88A 4wnwB-5g6rA:
undetectable		 4wnwB-5g6rA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ie2 OXALATE--COA LIGASE

(Arabidopsis
thaliana) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A  36
GLY A   8
LEU A   6
VAL A 191
VAL A  70
 None
 1.00A 4wnwB-5ie2A:
undetectable		 4wnwB-5ie2A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojl IMINE REDUCTASE

(Aspergillus
terreus) 		no annotation 5 GLY A 122
LEU A 138
ALA A 168
ASP A 167
SER A 140
 None
 0.88A 4wnwB-5ojlA:
undetectable		 4wnwB-5ojlA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcb PELA

(Pseudomonas
aeruginosa) 		PF03537
(Glyco_hydro_114) 		5 LEU A 162
ALA A 179
VAL A  99
VAL A 211
PHE A 198
 None
 0.88A 4wnwB-5tcbA:
undetectable		 4wnwB-5tcbA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tky PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		5 LEU A 200
GLY A 342
LEU A 204
VAL A 321
PHE A 209
 None
ATP  A 700 (-3.3A)
None
None
None
 1.13A 4wnwB-5tkyA:
0.0		 4wnwB-5tkyA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tv2 ELONGATION FACTOR G

(Vibrio
vulnificus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		5 GLY A 385
LEU A 386
ALA A 323
VAL A 389
PHE A 358
 None
 1.01A 4wnwB-5tv2A:
undetectable		 4wnwB-5tv2A:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7s FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Acinetobacter
baumannii) 		PF01116
(F_bP_aldolase) 		5 LEU A 229
GLY A 195
LEU A 212
SER A 234
VAL A 258
 None
 0.97A 4wnwB-5u7sA:
undetectable		 4wnwB-5u7sA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vre PUTATIVE INTEGRAL
MEMBRANE PROTEIN

(Chamaesiphon
minutus) 		PF06736
(DUF1211) 		5 GLY A  92
LEU A  94
ASP A  18
VAL A  98
PHE A 135
 None
 1.06A 4wnwB-5vreA:
0.2		 4wnwB-5vreA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weo GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF00822
(PMP22_Claudin)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 PHE A  74
GLY A 340
LEU A 341
VAL A 248
PHE A 258
 None
 1.06A 4wnwB-5weoA:
0.0		 4wnwB-5weoA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbk IMPORTIN-4

(Homo sapiens) 		no annotation 5 LEU D 904
GLY D 890
LEU D 889
ALA D 934
PHE D 855
 None
 1.11A 4wnwB-5xbkD:
undetectable		 4wnwB-5xbkD:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xkl ESX-3
SECRETION-ASSOCIATED
PROTEIN ESPG3

(Mycobacterium
tuberculosis) 		no annotation 5 GLY A 229
ALA A 171
ASP A 174
VAL A 242
VAL A  89
 None
 1.04A 4wnwB-5xklA:
undetectable		 4wnwB-5xklA:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykb TREHALOSE SYNTHASE

(Deinococcus
radiodurans) 		no annotation 5 PHE A 197
GLY A  79
LEU A  78
VAL A  19
VAL A  68
 None
 1.07A 4wnwB-5ykbA:
undetectable		 4wnwB-5ykbA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ynl ARGINASE

(Glaciozyma
antarctica) 		no annotation 5 LEU A 131
GLY A 189
LEU A 190
ALA A 226
VAL A 156
 None
 0.90A 4wnwB-5ynlA:
undetectable		 4wnwB-5ynlA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoe 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Cricetulus
griseus) 		no annotation 5 LEU A 221
GLY A 363
LEU A 225
VAL A 342
PHE A 230
 None
ADP  A 603 (-3.6A)
None
None
None
 1.07A 4wnwB-6eoeA:
undetectable		 4wnwB-6eoeA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1akp APOKEDARCIDIN

(actinomycete
ATCC 53650) 		PF00960
(Neocarzinostat) 		3 GLU A  51
ILE A 111
ALA A  34
 None
 0.67A 4wnwB-1akpA:
undetectable		 4wnwB-1akpA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg6 N-(1-D-CARBOXYLETHYL
)-L-NORVALINE
DEHYDROGENASE

(Arthrobacter
sp. 1C) 		PF02317
(Octopine_DH)
PF02558
(ApbA) 		3 GLU A 134
ILE A 354
ALA A 166
 None
 0.66A 4wnwB-1bg6A:
0.0		 4wnwB-1bg6A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmw PHENYLALANINE
HYDROXYLASE

(Homo sapiens) 		PF00351
(Biopterin_H) 		3 GLU A 183
ILE A 164
ALA A 156
 None
 0.60A 4wnwB-1dmwA:
0.0		 4wnwB-1dmwA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba) 		PF00232
(Glyco_hydro_1) 		3 GLU M 314
ILE M 225
ALA M 233
 None
 0.59A 4wnwB-1dwaM:
0.0		 4wnwB-1dwaM:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ea6 PMS1 PROTEIN HOMOLOG
2

(Homo sapiens) 		PF01119
(DNA_mis_repair)
PF13589
(HATPase_c_3) 		3 GLU A  44
ILE A 292
ALA A 190
 None
 0.60A 4wnwB-1ea6A:
0.0		 4wnwB-1ea6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 GLU A 162
ILE A  64
ALA A  68
 None
 0.51A 4wnwB-1j6uA:
0.0		 4wnwB-1j6uA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwm PROCARBOXYPEPTIDASE
B

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		3 GLU A 175
ILE A 139
ALA A  70
 None
 0.63A 4wnwB-1kwmA:
0.0		 4wnwB-1kwmA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1f GLUTAMATE
DEHYDROGENASE 1

(Homo sapiens) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 GLU A 320
ILE A 363
ALA A 345
 None
 0.62A 4wnwB-1l1fA:
0.0		 4wnwB-1l1fA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt6 SET9

(Homo sapiens) 		PF00856
(SET)
PF02493
(MORN) 		3 GLU A 212
ILE A 275
ALA A 295
 None
 0.63A 4wnwB-1mt6A:
0.0		 4wnwB-1mt6A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl4 PMBA-RELATED PROTEIN

(Thermotoga
maritima) 		PF01523
(PmbA_TldD) 		3 GLU A 358
ILE A 201
ALA A 209
 None
 0.66A 4wnwB-1vl4A:
undetectable		 4wnwB-1vl4A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		3 GLU A 161
ILE A 291
ALA A  33
 None
 0.65A 4wnwB-1wd3A:
undetectable		 4wnwB-1wd3A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xwm PHOSPHATE UPTAKE
REGULATOR

(Geobacillus
stearothermophilus) 		PF01895
(PhoU) 		3 GLU A  24
ILE A  86
ALA A  94
 None
 0.53A 4wnwB-1xwmA:
undetectable		 4wnwB-1xwmA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yb5 QUINONE
OXIDOREDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLU A 150
ILE A 244
ALA A 169
 None
 0.63A 4wnwB-1yb5A:
undetectable		 4wnwB-1yb5A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zli CARBOXYPEPTIDASE B

(Homo sapiens) 		PF00246
(Peptidase_M14) 		3 GLU A 175
ILE A 139
ALA A  70
 None
 0.62A 4wnwB-1zliA:
undetectable		 4wnwB-1zliA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		3 GLU A1046
ILE A 166
ALA A1093
 None
 0.66A 4wnwB-2b39A:
undetectable		 4wnwB-2b39A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4m GLYCINE
BETAINE-BINDING
PROTEIN

(Bacillus
subtilis) 		PF04069
(OpuAC) 		3 GLU A 181
ILE A  21
ALA A 206
 PBE  A 311 ( 4.6A)
None
None
 0.66A 4wnwB-2b4mA:
undetectable		 4wnwB-2b4mA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4m GLYCINE
BETAINE-BINDING
PROTEIN

(Bacillus
subtilis) 		PF04069
(OpuAC) 		3 GLU A 181
ILE A  27
ALA A 206
 PBE  A 311 ( 4.6A)
PBE  A 311 (-3.6A)
None
 0.67A 4wnwB-2b4mA:
undetectable		 4wnwB-2b4mA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2di4 CELL DIVISION
PROTEIN FTSH HOMOLOG

(Aquifex
aeolicus) 		PF01434
(Peptidase_M41) 		3 GLU A 567
ILE A 417
ALA A 562
 None
 0.60A 4wnwB-2di4A:
1.8		 4wnwB-2di4A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF00232
(Glyco_hydro_1) 		3 GLU A 285
ILE A 196
ALA A 204
 None
 0.56A 4wnwB-2e3zA:
undetectable		 4wnwB-2e3zA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8q ALKALINE
THERMOSTABLE
ENDOXYLANASE

(Bacillus sp.
NG-27) 		PF00331
(Glyco_hydro_10) 		3 GLU A  26
ILE A  54
ALA A  68
 None
 0.65A 4wnwB-2f8qA:
undetectable		 4wnwB-2f8qA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdn ELONGATION FACTOR
EF-TU

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		3 GLU B 232
ILE B 366
ALA B 293
 None
 0.63A 4wnwB-2hdnB:
undetectable		 4wnwB-2hdnB:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijc HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF02627
(CMD) 		3 GLU A  31
ILE A 120
ALA A  28
 None
 0.46A 4wnwB-2ijcA:
undetectable		 4wnwB-2ijcA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kjp UNCHARACTERIZED
PROTEIN YLBL

(Bacillus
subtilis) 		PF13180
(PDZ_2) 		3 GLU A  19
ILE A  39
ALA A  27
 None
 0.65A 4wnwB-2kjpA:
undetectable		 4wnwB-2kjpA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4d HYPOTHETICAL PROTEIN
PA0269

(Pseudomonas
aeruginosa) 		PF02627
(CMD) 		3 GLU A  31
ILE A 120
ALA A  28
 None
 0.64A 4wnwB-2o4dA:
undetectable		 4wnwB-2o4dA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pan GLYOXYLATE
CARBOLIGASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 GLU A  52
ILE A 393
ALA A 427
 None
TDP  A 801 ( 4.1A)
None
 0.57A 4wnwB-2panA:
undetectable		 4wnwB-2panA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prr ALKYLHYDROPEROXIDASE
AHPD CORE:
UNCHARACTERIZED
PEROXIDASE-RELATED
PROTEIN

(Cupriavidus
pinatubonensis) 		PF02627
(CMD) 		3 GLU A 185
ILE A   8
ALA A  92
 None
 0.61A 4wnwB-2prrA:
undetectable		 4wnwB-2prrA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhk NON-STRUCTURAL
PROTEIN 1

(Influenza A
virus) 		PF00600
(Flu_NS1) 		3 GLU A 172
ILE A 137
ALA A 202
 None
 0.44A 4wnwB-2rhkA:
undetectable		 4wnwB-2rhkA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6d DYNAMIN FAMILY
PROTEIN

(Nostoc
punctiforme) 		PF00350
(Dynamin_N) 		3 GLU A 622
ILE A 389
ALA A 397
 None
 0.59A 4wnwB-2w6dA:
2.1		 4wnwB-2w6dA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhz ARABINOSE
5-PHOSPHATE
ISOMERASE

(Escherichia
coli) 		PF01380
(SIS) 		3 GLU A  23
ILE A  63
ALA A 159
 None
 0.66A 4wnwB-2xhzA:
undetectable		 4wnwB-2xhzA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzs PUTATIVE
UNCHARACTERIZED
PROTEIN

(Aquifex
aeolicus) 		PF01867
(Cas_Cas1) 		3 GLU A 143
ILE A 178
ALA A 220
 None
 0.51A 4wnwB-2yzsA:
undetectable		 4wnwB-2yzsA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38) 		PF00353
(HemolysinCabind) 		3 GLU A 112
ILE A 138
ALA A 119
 None
 0.64A 4wnwB-2z8zA:
undetectable		 4wnwB-2z8zA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ada SARCOSINE OXIDASE
BETA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01266
(DAO) 		3 GLU B  52
ILE B 327
ALA B  62
 FAD  B   1 (-2.8A)
None
FMN  B   4 (-4.1A)
 0.57A 4wnwB-3adaB:
undetectable		 4wnwB-3adaB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agr NUCLEOSIDE
TRIPHOSPHATE
HYDROLASE

(Neospora
caninum) 		PF01150
(GDA1_CD39) 		3 GLU A 253
ILE A 207
ALA A 257
 None
 0.58A 4wnwB-3agrA:
undetectable		 4wnwB-3agrA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3at6 BETA-GLOBIN

(Podocnemis
unifilis) 		PF00042
(Globin) 		3 GLU B 101
ILE B 109
ALA B 138
 None
 0.50A 4wnwB-3at6B:
undetectable		 4wnwB-3at6B:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcz PROTEIN MEMO1

(Homo sapiens) 		PF01875
(Memo) 		3 GLU A 166
ILE A 224
ALA A 255
 GOL  A 303 (-3.7A)
None
None
 0.60A 4wnwB-3bczA:
undetectable		 4wnwB-3bczA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1l PUTATIVE ANTIOXIDANT
DEFENSE PROTEIN
MLR4105

(Mesorhizobium
japonicum) 		PF02627
(CMD) 		3 GLU A 181
ILE A   5
ALA A  88
 None
None
PEG  A 190 ( 3.8A)
 0.66A 4wnwB-3c1lA:
undetectable		 4wnwB-3c1lA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7

(Homo sapiens) 		PF00856
(SET) 		3 GLU A 212
ILE A 275
ALA A 295
 None
 0.60A 4wnwB-3cboA:
undetectable		 4wnwB-3cboA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdi POLYNUCLEOTIDE
PHOSPHORYLASE

(Escherichia
coli) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		3 GLU A  88
ILE A 151
ALA A 138
 None
 0.47A 4wnwB-3cdiA:
2.2		 4wnwB-3cdiA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwc PUTATIVE GLYCERATE
KINASE 2

(Salmonella
enterica) 		PF02595
(Gly_kinase) 		3 GLU A 217
ILE A 166
ALA A 214
 None
 0.66A 4wnwB-3cwcA:
undetectable		 4wnwB-3cwcA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ee9 NON-STRUCTURAL
PROTEIN 1

(Influenza A
virus) 		PF00600
(Flu_NS1) 		3 GLU A 172
ILE A 137
ALA A 202
 None
 0.60A 4wnwB-3ee9A:
undetectable		 4wnwB-3ee9A:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj7 MAJOR ANTIGENIC
PEPTIDE PEB3

(Campylobacter
jejuni) 		PF13531
(SBP_bac_11) 		3 GLU A 206
ILE A 127
ALA A 102
 None
 0.62A 4wnwB-3fj7A:
undetectable		 4wnwB-3fj7A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7r PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		3 GLU A 118
ILE A  26
ALA A 111
 None
 0.59A 4wnwB-3g7rA:
0.6		 4wnwB-3g7rA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iwg ACETYLTRANSFERASE,
GNAT FAMILY

(Colwellia
psychrerythraea) 		PF00583
(Acetyltransf_1) 		3 GLU A 244
ILE A 210
ALA A 249
 None
None
SO4  A 501 ( 4.2A)
 0.64A 4wnwB-3iwgA:
undetectable		 4wnwB-3iwgA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9q SHEATH

(Pseudomonas
aeruginosa) 		PF04984
(Phage_sheath_1)
PF17482
(Phage_sheath_1C) 		3 GLU A 214
ILE A  19
ALA A  23
 None
 0.53A 4wnwB-3j9qA:
undetectable		 4wnwB-3j9qA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jux PROTEIN TRANSLOCASE
SUBUNIT SECA

(Thermotoga
maritima) 		PF00271
(Helicase_C)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		3 GLU A 425
ILE A 563
ALA A 419
 None
 0.64A 4wnwB-3juxA:
undetectable		 4wnwB-3juxA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kz1 RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 11

(Homo sapiens) 		PF00621
(RhoGEF) 		3 GLU A 928
ILE A 876
ALA A 839
 None
 0.49A 4wnwB-3kz1A:
undetectable		 4wnwB-3kz1A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ly1 PUTATIVE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Pectobacterium
atrosepticum) 		PF00155
(Aminotran_1_2) 		3 GLU A 119
ILE A 151
ALA A 124
 None
 0.61A 4wnwB-3ly1A:
undetectable		 4wnwB-3ly1A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		3 GLU A 345
ILE A 372
ALA A 363
 None
 0.59A 4wnwB-3mc2A:
undetectable		 4wnwB-3mc2A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moy PROBABLE ENOYL-COA
HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		3 GLU A 113
ILE A  69
ALA A  64
 EDO  A 262 (-2.7A)
None
None
 0.58A 4wnwB-3moyA:
undetectable		 4wnwB-3moyA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpn TRANSPORTER

(Aquifex
aeolicus) 		PF00209
(SNF) 		3 GLU A   6
ILE A 357
ALA A 365
 None
 0.58A 4wnwB-3mpnA:
undetectable		 4wnwB-3mpnA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nu8 AMINOTRANSFERASE
WBPE

(Pseudomonas
aeruginosa) 		PF01041
(DegT_DnrJ_EryC1) 		3 GLU A 202
ILE A 222
ALA A  69
 None
 0.63A 4wnwB-3nu8A:
undetectable		 4wnwB-3nu8A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		3 GLU A 684
ILE A 330
ALA A 679
 None
 0.53A 4wnwB-3qdeA:
undetectable		 4wnwB-3qdeA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swt TAURINE CATABOLISM
DIOXYGENASE, TAUD

(Mycobacterium
marinum) 		PF02668
(TauD) 		3 GLU A 195
ILE A 247
ALA A 252
 None
 0.37A 4wnwB-3swtA:
undetectable		 4wnwB-3swtA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujg SERINE/THREONINE-PRO
TEIN KINASE SRK2E

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		3 GLU A  60
ILE A 305
ALA A 313
 None
 0.65A 4wnwB-3ujgA:
undetectable		 4wnwB-3ujgA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		3 GLU B 360
ILE B 298
ALA B 287
 None
 0.51A 4wnwB-4ci2B:
undetectable		 4wnwB-4ci2B:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		3 GLU A 186
ILE A 170
ALA A 180
 None
 0.61A 4wnwB-4cpnA:
undetectable		 4wnwB-4cpnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvy DIOXYGENASE
RV3406/MT3514

(Mycobacterium
tuberculosis) 		PF02668
(TauD) 		3 GLU A 191
ILE A 243
ALA A  40
 None
 0.60A 4wnwB-4cvyA:
undetectable		 4wnwB-4cvyA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvy DIOXYGENASE
RV3406/MT3514

(Mycobacterium
tuberculosis) 		PF02668
(TauD) 		3 GLU A 191
ILE A 243
ALA A 248
 None
 0.38A 4wnwB-4cvyA:
undetectable		 4wnwB-4cvyA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		3 GLU A  31
ILE A  99
ALA A 370
 None
 0.66A 4wnwB-4djiA:
0.5		 4wnwB-4djiA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ehj PHOSPHOGLYCERATE
KINASE

(Francisella
tularensis) 		PF00162
(PGK) 		3 GLU A 225
ILE A 298
ALA A 218
 None
 0.62A 4wnwB-4ehjA:
undetectable		 4wnwB-4ehjA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewt PEPTIDASE,
M20/M25/M40 FAMILY

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 GLU A  28
ILE A  60
ALA A 137
 None
 0.64A 4wnwB-4ewtA:
undetectable		 4wnwB-4ewtA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmk POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 2

(Mus musculus) 		PF07686
(V-set)
PF08205
(C2-set_2) 		3 GLU A 234
ILE A 210
ALA A 151
 None
 0.64A 4wnwB-4fmkA:
undetectable		 4wnwB-4fmkA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxb PUTATIVE CYTOCHROME
P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		3 GLU A  91
ILE A 322
ALA A  75
 None
 0.65A 4wnwB-4fxbA:
29.6		 4wnwB-4fxbA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnr CHEMOTAXIS PROTEIN
CHEY

(Vibrio cholerae) 		PF00072
(Response_reg) 		3 GLU A  36
ILE A  11
ALA A   6
 None
 0.45A 4wnwB-4hnrA:
undetectable		 4wnwB-4hnrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8q PUTATIVE BETAINE
ALDEHYDE
DEHYROGENASE

(Solanum
lycopersicum) 		PF00171
(Aldedh) 		3 GLU A 119
ILE A 200
ALA A 173
 None
 0.63A 4wnwB-4i8qA:
undetectable		 4wnwB-4i8qA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5i ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Mycolicibacterium
smegmatis) 		PF02668
(TauD) 		3 GLU A 188
ILE A  44
ALA A 245
 None
 0.65A 4wnwB-4j5iA:
undetectable		 4wnwB-4j5iA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5i ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Mycolicibacterium
smegmatis) 		PF02668
(TauD) 		3 GLU A 188
ILE A 240
ALA A 245
 None
 0.40A 4wnwB-4j5iA:
undetectable		 4wnwB-4j5iA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ld7 DIMETHYLALLYL
TRYPTOPHAN SYNTHASE

(Aspergillus
fischeri) 		PF11991
(Trp_DMAT) 		3 GLU A 344
ILE A 206
ALA A 268
 None
 0.64A 4wnwB-4ld7A:
undetectable		 4wnwB-4ld7A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea) 		PF00232
(Glyco_hydro_1) 		3 GLU A 292
ILE A 202
ALA A 210
 None
PEG  A 504 ( 4.4A)
None
 0.63A 4wnwB-4mdpA:
undetectable		 4wnwB-4mdpA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4u PUTATIVE ABC
TRANSPORTER
PERIPLASMIC
SOLUTE-BINDING
PROTEIN

(Bordetella
bronchiseptica) 		PF03480
(DctP) 		3 GLU A 269
ILE A 212
ALA A 275
 None
 0.45A 4wnwB-4n4uA:
undetectable		 4wnwB-4n4uA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzs BETA-KETOTHIOLASE
BKTB

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		3 GLU A   4
ILE A 390
ALA A 101
 None
 0.59A 4wnwB-4nzsA:
undetectable		 4wnwB-4nzsA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1e DIHYDROPTEROATE
SYNTHASE DHPS

(Desulfitobacterium
hafniense) 		PF00809
(Pterin_bind) 		3 GLU A 107
ILE A 140
ALA A 148
 None
 0.58A 4wnwB-4o1eA:
undetectable		 4wnwB-4o1eA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofz TREHALOSE-PHOSPHATAS
E

(Brugia malayi) 		no annotation 3 GLU A 386
ILE A 395
ALA A 389
 None
 0.64A 4wnwB-4ofzA:
undetectable		 4wnwB-4ofzA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ol9 PUTATIVE
2-DEHYDROPANTOATE
2-REDUCTASE

(Mycobacterium
tuberculosis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		3 GLU A 258
ILE A 121
ALA A  72
 NAP  A 301 (-2.8A)
None
None
 0.66A 4wnwB-4ol9A:
undetectable		 4wnwB-4ol9A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4raa PUTATIVE EXPORTED
PROTEIN

(Bacteroides
fragilis) 		PF17170
(DUF5128) 		3 GLU A 145
ILE A 108
ALA A 124
 None
 0.51A 4wnwB-4raaA:
undetectable		 4wnwB-4raaA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u30 TRYPSTATIN

(Homo sapiens) 		no annotation 3 GLU X  50
ILE X  18
ALA X  22
 None
 0.66A 4wnwB-4u30X:
undetectable		 4wnwB-4u30X:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0e PUTATIVE DIOXYGENASE

(Mycobacteroides
abscessus) 		PF02668
(TauD) 		3 GLU A 202
ILE A 254
ALA A 259
 MPD  A 402 (-2.9A)
None
None
 0.43A 4wnwB-4y0eA:
undetectable		 4wnwB-4y0eA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		3 GLU C 261
ILE C 267
ALA C 543
 None
 0.62A 4wnwB-5aa5C:
undetectable		 4wnwB-5aa5C:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6o HOMOSERINE
O-ACETYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF00561
(Abhydrolase_1) 		3 GLU A 307
ILE A 115
ALA A 280
 None
 0.66A 4wnwB-5d6oA:
1.3		 4wnwB-5d6oA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx9 TREHALOSE-6-PHOSPHAT
E PHOSPHATASE

(Cryptococcus
neoformans) 		PF02358
(Trehalose_PPase) 		3 GLU A 249
ILE A 100
ALA A 105
 None
 0.64A 4wnwB-5dx9A:
undetectable		 4wnwB-5dx9A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fic SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		3 GLU A 460
ILE A 424
ALA A 477
 None
 0.65A 4wnwB-5ficA:
undetectable		 4wnwB-5ficA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 2

(Homo sapiens) 		no annotation 3 GLU I 398
ILE I 377
ALA I 453
 None
 0.56A 4wnwB-5furI:
undetectable		 4wnwB-5furI:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0i ASPARAGINYL
ENDOPEPTIDASE

(Oldenlandia
affinis) 		PF01650
(Peptidase_C13) 		3 GLU A 405
ILE A 457
ALA A 409
 None
 0.63A 4wnwB-5h0iA:
undetectable		 4wnwB-5h0iA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hqn SPHINGOMYELIN
PHOSPHODIESTERASE

(Mus musculus) 		PF00149
(Metallophos) 		3 GLU A 460
ILE A 424
ALA A 477
 None
 0.63A 4wnwB-5hqnA:
undetectable		 4wnwB-5hqnA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvf CARBOXYPEPTIDASE B2

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		3 GLU A 266
ILE A 229
ALA A 160
 None
 0.59A 4wnwB-5hvfA:
undetectable		 4wnwB-5hvfA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id6 CPF1

(Lachnospiraceae
bacterium
ND2006) 		no annotation 3 GLU A1168
ILE A1072
ALA A1179
 None
 0.65A 4wnwB-5id6A:
undetectable		 4wnwB-5id6A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1q CARBOXYPEPTIDASE B

(Sus scrofa) 		PF00246
(Peptidase_M14) 		3 GLU A 175
ILE A 139
ALA A  70
 None
 0.51A 4wnwB-5j1qA:
undetectable		 4wnwB-5j1qA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3h ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		3 GLU A 360
ILE A 492
ALA A 353
 None
 0.64A 4wnwB-5k3hA:
undetectable		 4wnwB-5k3hA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k94 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PROTEIN
TRANSLOCASE SUBUNIT
SECA,MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		3 GLU A 368
ILE A 335
ALA A 356
 None
 0.53A 4wnwB-5k94A:
undetectable		 4wnwB-5k94A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdj F5/8 TYPE C DOMAIN
PROTEIN

(Clostridium
perfringens) 		no annotation 3 GLU B 845
ILE B 861
ALA B 869
 None
 0.59A 4wnwB-5kdjB:
undetectable		 4wnwB-5kdjB:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kds F5/8 TYPE C DOMAIN
PROTEIN

(Clostridium
perfringens) 		PF13402
(Peptidase_M60) 		3 GLU A 845
ILE A 861
ALA A 869
 None
 0.54A 4wnwB-5kdsA:
undetectable		 4wnwB-5kdsA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msc CARBOXYLIC ACID
REDUCTASE

(Nocardia
iowensis) 		PF00501
(AMP-binding) 		3 GLU A  99
ILE A 126
ALA A 134
 None
 0.65A 4wnwB-5mscA:
undetectable		 4wnwB-5mscA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n29 CTP SYNTHASE

(Trypanosoma
brucei) 		PF00117
(GATase) 		3 GLU A 370
ILE A 427
ALA A 404
 None
 0.66A 4wnwB-5n29A:
undetectable		 4wnwB-5n29A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 3 GLU A 361
ILE B 998
ALA A 358
 None
 0.53A 4wnwB-5nd1A:
undetectable		 4wnwB-5nd1A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn6 TAURINE DIOXYGENASE

(Burkholderia
ambifaria) 		PF02668
(TauD) 		3 GLU A 187
ILE A 250
ALA A 255
 None
 0.47A 4wnwB-5vn6A:
undetectable		 4wnwB-5vn6A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zby HYDROGENASE
MATURATION PROTEASE
HYCI

(Thermococcus
kodakarensis) 		no annotation 3 GLU A 134
ILE A  82
ALA A  28
 None
 0.66A 4wnwB-5zbyA:
undetectable		 4wnwB-5zbyA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bcq TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY M
MEMBER 4

(Mus musculus) 		no annotation 3 GLU B 824
ILE B 897
ALA B 817
 None
 0.49A 4wnwB-6bcqB:
undetectable		 4wnwB-6bcqB:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bq6 THERMOSPERMINE
SYNTHASE

(Medicago
truncatula) 		no annotation 3 GLU A 109
ILE A 248
ALA A  67
 None
 0.63A 4wnwB-6bq6A:
undetectable		 4wnwB-6bq6A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cdd NPL4 ZINC FINGER

(Chaetomium
thermophilum) 		no annotation 3 GLU A 513
ILE A 267
ALA A 274
 None
 0.59A 4wnwB-6cddA:
undetectable		 4wnwB-6cddA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gdt -

(-) 		no annotation 3 GLU A 442
ILE A 401
ALA A 475
 None
 0.50A 4wnwB-6gdtA:
undetectable		 4wnwB-6gdtA:
undetectable