SIMILAR PATTERNS OF AMINO ACIDS FOR 4WNV_D_QI9D602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b6r PROTEIN
(N5-CARBOXYAMINOIMID
AZOLE RIBONUCLEOTIDE
SYNTHETASE)

(Escherichia
coli) 		PF02222
(ATP-grasp) 		4 SER A 246
THR A 250
VAL A 222
PHE A 176
 None
 1.06A 4wnvD-1b6rA:
undetectable		 4wnvD-1b6rA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cb8 PROTEIN
(CHONDROITINASE AC)

(Pedobacter
heparinus) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 PHE A 184
LEU A 181
THR A 252
VAL A  35
 None
 0.92A 4wnvD-1cb8A:
0.5		 4wnvD-1cb8A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfr RESTRICTION
ENDONUCLEASE

(Citrobacter
freundii) 		PF07832
(Bse634I) 		4 GLU A  84
SER A 155
VAL A 272
PHE A  81
 None
 1.02A 4wnvD-1cfrA:
0.1		 4wnvD-1cfrA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cz3 DIHYDROFOLATE
REDUCTASE

(Thermotoga
maritima) 		PF00186
(DHFR_1) 		4 PHE A 141
LEU A 143
VAL A 115
PHE A 106
 None
 0.93A 4wnvD-1cz3A:
undetectable		 4wnvD-1cz3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6h CHALCONE SYNTHASE

(Medicago sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 PHE A 287
LEU A 290
SER A 297
VAL A 383
 None
 0.91A 4wnvD-1d6hA:
0.0		 4wnvD-1d6hA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1emy MYOGLOBIN

(Elephas maximus) 		PF00042
(Globin) 		4 PHE A  46
LEU A  49
GLU A  26
THR A  67
 None
None
None
HEM  A 154 ( 4.9A)
 0.99A 4wnvD-1emyA:
undetectable		 4wnvD-1emyA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpw CALCIUM-BINDING
PROTEIN NCS-1

(Saccharomyces
cerevisiae) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		4 LEU A 110
SER A 127
VAL A  71
PHE A  69
 None
 1.04A 4wnvD-1fpwA:
0.0		 4wnvD-1fpwA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8k ARSENITE OXIDASE

(Alcaligenes
faecalis) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 PHE A 243
LEU A 244
THR A 281
PHE A 824
 None
None
MGD  A5002 (-4.4A)
None
 0.87A 4wnvD-1g8kA:
0.3		 4wnvD-1g8kA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gve AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3

(Rattus
norvegicus) 		PF00248
(Aldo_ket_red) 		4 PHE A 190
LEU A 183
VAL A 175
PHE A 326
 None
GOL  A1330 ( 4.6A)
None
None
 0.93A 4wnvD-1gveA:
0.0		 4wnvD-1gveA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 PHE A 501
THR A 549
VAL A 126
PHE A 513
 None
 0.99A 4wnvD-1h0hA:
0.0		 4wnvD-1h0hA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR

(Homo sapiens) 		PF03261
(CDK5_activator) 		4 PHE D 248
LEU D 227
SER D 233
VAL D 181
 None
 1.05A 4wnvD-1h4lD:
2.1		 4wnvD-1h4lD:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqk CARBON MONOXIDE
DEHYDROGENASE

(Rhodospirillum
rubrum) 		PF03063
(Prismane) 		4 LEU A 185
SER A 574
THR A 583
VAL A 609
 None
 0.98A 4wnvD-1jqkA:
1.8		 4wnvD-1jqkA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kph CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		4 PHE A 283
LEU A 166
GLU A 140
VAL A 211
 None
None
CO3  A1902 ( 3.6A)
None
 1.02A 4wnvD-1kphA:
0.9		 4wnvD-1kphA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mgt PROTEIN
(O6-METHYLGUANINE-DN
A METHYLTRANSFERASE)

(Thermococcus
kodakarensis) 		PF01035
(DNA_binding_1)
PF09153
(DUF1938) 		4 LEU A 163
SER A 155
THR A  35
VAL A  14
 None
 1.06A 4wnvD-1mgtA:
undetectable		 4wnvD-1mgtA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ms8 TRANS-SIALIDASE

(Trypanosoma
cruzi) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		4 PHE A  34
THR A  79
VAL A  31
PHE A  20
 None
 0.91A 4wnvD-1ms8A:
undetectable		 4wnvD-1ms8A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mz5 SIALIDASE

(Trypanosoma
rangeli) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		4 PHE A  35
THR A  80
VAL A  32
PHE A  20
 None
 0.98A 4wnvD-1mz5A:
undetectable		 4wnvD-1mz5A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd1 PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 PHE A 916
LEU A 917
SER A 716
VAL A 679
 None
 1.06A 4wnvD-1pd1A:
1.8		 4wnvD-1pd1A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1unl CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR 1

(Homo sapiens) 		PF03261
(CDK5_activator) 		4 PHE D 248
LEU D 227
SER D 233
VAL D 181
 None
 1.06A 4wnvD-1unlD:
undetectable		 4wnvD-1unlD:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4a GLUTAMATE-AMMONIA-LI
GASE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF03710
(GlnE)
PF08335
(GlnD_UR_UTase) 		4 LEU A  56
SER A  34
VAL A  46
PHE A  41
 None
 0.95A 4wnvD-1v4aA:
0.1		 4wnvD-1v4aA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vh2 S-RIBOSYLHOMOCYSTEIN
ASE

(Deinococcus
radiodurans) 		PF02664
(LuxS) 		4 PHE A  43
LEU A  44
THR A 110
VAL A 143
 None
 1.06A 4wnvD-1vh2A:
undetectable		 4wnvD-1vh2A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x5p NEGATIVE ELONGATION
FACTOR E

(Homo sapiens) 		PF00076
(RRM_1) 		4 PHE A  34
LEU A  43
THR A  72
VAL A  20
 None
 0.87A 4wnvD-1x5pA:
undetectable		 4wnvD-1x5pA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xf1 C5A PEPTIDASE

(Streptococcus
pyogenes) 		PF00082
(Peptidase_S8)
PF02225
(PA)
PF06280
(fn3_5)
PF13585
(CHU_C) 		4 PHE A 692
LEU A 622
SER A 551
VAL A 663
 None
 0.88A 4wnvD-1xf1A:
undetectable		 4wnvD-1xf1A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xyz 1,4-BETA-D-XYLAN-XYL
ANOHYDROLASE

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10) 		4 LEU A 834
SER A 554
THR A 531
PHE A 752
 None
 1.00A 4wnvD-1xyzA:
undetectable		 4wnvD-1xyzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bp1 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 PHE A 223
LEU A 216
VAL A 208
PHE A 359
 None
 0.93A 4wnvD-2bp1A:
undetectable		 4wnvD-2bp1A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c91 AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 2

(Mus musculus) 		PF00248
(Aldo_ket_red) 		4 PHE A 190
LEU A 183
VAL A 175
PHE A 326
 None
 1.00A 4wnvD-2c91A:
undetectable		 4wnvD-2c91A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2clp AFLATOXIN B1
ALDEHYDE REDUCTASE
MEMBER 3

(Homo sapiens) 		PF00248
(Aldo_ket_red) 		4 PHE A 223
LEU A 216
VAL A 208
PHE A 359
 None
 0.92A 4wnvD-2clpA:
undetectable		 4wnvD-2clpA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cqg TAR DNA-BINDING
PROTEIN-43

(Homo sapiens) 		PF00076
(RRM_1) 		4 PHE A 124
THR A 115
VAL A 108
PHE A 147
 None
 1.05A 4wnvD-2cqgA:
undetectable		 4wnvD-2cqgA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e87 HYPOTHETICAL PROTEIN
PH1320

(Pyrococcus
horikoshii) 		PF06858
(NOG1) 		4 PHE A   5
THR A  73
VAL A  82
PHE A  77
 None
SO4  A 401 ( 4.5A)
None
None
 0.95A 4wnvD-2e87A:
undetectable		 4wnvD-2e87A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejw HOMOSERINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 LEU A 199
SER A 132
VAL A 274
PHE A 283
 None
 1.00A 4wnvD-2ejwA:
undetectable		 4wnvD-2ejwA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9f FIRST MANNOSYL
TRANSFERASE (WBAZ-1)

(Archaeoglobus
fulgidus) 		PF00534
(Glycos_transf_1) 		4 LEU A  30
SER A  18
THR A 103
VAL A 117
 None
 1.00A 4wnvD-2f9fA:
undetectable		 4wnvD-2f9fA:
15.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		5 PHE A 120
LEU A 121
GLU A 216
SER A 304
THR A 309
 HEM  A 600 (-4.6A)
None
None
None
HEM  A 600 (-3.5A)
 1.10A 4wnvD-2f9qA:
55.5		 4wnvD-2f9qA:
99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ip1 TRYPTOPHANYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00579
(tRNA-synt_1b) 		4 PHE A 279
LEU A 202
SER A 281
THR A 286
 None
 1.01A 4wnvD-2ip1A:
undetectable		 4wnvD-2ip1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2onk MOLYBDATE/TUNGSTATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN
MOLYBDATE/TUNGSTATE
ABC TRANSPORTER,
PERMEASE PROTEIN

(Archaeoglobus
fulgidus;
Archaeoglobus
fulgidus) 		PF00005
(ABC_tran)
PF00528
(BPD_transp_1) 		4 PHE A  82
LEU A  85
THR C 164
VAL C 176
 None
 1.03A 4wnvD-2onkA:
undetectable		 4wnvD-2onkA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uv8 FATTY ACID SYNTHASE
SUBUNIT BETA (FAS1)

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF01575
(MaoC_dehydratas)
PF08354
(DUF1729)
PF13452
(MaoC_dehydrat_N)
PF16073
(SAT) 		4 PHE G 292
SER G 295
VAL G 250
PHE G 504
 None
 1.05A 4wnvD-2uv8G:
0.0		 4wnvD-2uv8G:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vca ALPHA-N-ACETYLGLUCOS
AMINIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C) 		4 PHE A 318
LEU A 319
THR A 302
VAL A 330
 None
 0.87A 4wnvD-2vcaA:
undetectable		 4wnvD-2vcaA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE

(Mycobacterium
tuberculosis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 PHE A 236
LEU A 272
SER A 143
VAL A 221
 None
 0.98A 4wnvD-2wtzA:
undetectable		 4wnvD-2wtzA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn6 THYROXINE-BINDING
GLOBULIN

(Homo sapiens) 		PF00079
(Serpin) 		4 PHE A 249
LEU A 237
THR A 342
VAL A 285
 None
 0.75A 4wnvD-2xn6A:
undetectable		 4wnvD-2xn6A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc2 DNAD-LIKE
REPLICATION PROTEIN

(Streptococcus
mutans) 		PF07261
(DnaB_2) 		4 PHE A 131
LEU A 135
GLU A 143
THR A 150
 None
 1.05A 4wnvD-2zc2A:
undetectable		 4wnvD-2zc2A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bi3 ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB

(Escherichia
coli) 		PF13532
(2OG-FeII_Oxy_2) 		4 PHE A 154
LEU A 168
SER A 147
THR A 208
 None
None
AKG  A 302 ( 4.7A)
AKG  A 302 (-3.7A)
 1.05A 4wnvD-3bi3A:
undetectable		 4wnvD-3bi3A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dec BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 PHE A 932
LEU A 961
THR A 888
VAL A 912
 None
 0.99A 4wnvD-3decA:
undetectable		 4wnvD-3decA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6t ASPARTATE
AMINOTRANSFERASE

(Lactobacillus
acidophilus) 		PF00155
(Aminotran_1_2) 		4 PHE A  87
LEU A  86
VAL A 105
PHE A 100
 None
 0.94A 4wnvD-3f6tA:
undetectable		 4wnvD-3f6tA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvq FE(3+) IONS IMPORT
ATP-BINDING PROTEIN
FBPC

(Neisseria
gonorrhoeae) 		PF00005
(ABC_tran) 		4 LEU A  47
THR A 220
VAL A 193
PHE A  34
 None
 1.04A 4wnvD-3fvqA:
undetectable		 4wnvD-3fvqA:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gir AMINOMETHYLTRANSFERA
SE

(Bartonella
henselae) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 PHE A 277
LEU A  99
SER A 280
VAL A 261
 None
 1.04A 4wnvD-3girA:
undetectable		 4wnvD-3girA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbh MYOSIN 2 HEAVY CHAIN
STRIATED MUSCLE

(Aphonopelma) 		PF00063
(Myosin_head)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N) 		5 PHE A 333
LEU A 336
THR A 350
VAL A 223
PHE A 433
 None
 1.29A 4wnvD-3jbhA:
undetectable		 4wnvD-3jbhA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacteroides
thetaiotaomicron) 		PF08543
(Phos_pyr_kin) 		4 LEU A  23
THR A 231
VAL A  37
PHE A  77
 None
 1.02A 4wnvD-3mbhA:
undetectable		 4wnvD-3mbhA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nns DNA BINDING RESPONSE
REGULATOR B

(Thermotoga
maritima) 		PF00072
(Response_reg) 		4 PHE A  37
GLU A  42
THR A  68
VAL A  47
 None
 0.92A 4wnvD-3nnsA:
undetectable		 4wnvD-3nnsA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psh PROTEIN HI_1472

(Haemophilus
influenzae) 		PF01497
(Peripla_BP_2) 		4 LEU A  73
GLU A 305
THR A 342
VAL A  54
 None
 1.00A 4wnvD-3pshA:
undetectable		 4wnvD-3pshA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc2 GLYCOSYL HYDROLASE

(Bacteroides
ovatus) 		PF04041
(Glyco_hydro_130) 		4 PHE A 192
THR A 237
VAL A 248
PHE A 234
 None
 0.96A 4wnvD-3qc2A:
undetectable		 4wnvD-3qc2A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
phage 201phi2-1) 		PF00091
(Tubulin) 		4 GLU A 167
SER A 163
VAL A 118
PHE A 116
 None
None
GDP  A 400 (-4.6A)
None
 1.04A 4wnvD-3r4vA:
undetectable		 4wnvD-3r4vA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sop NEURONAL-SPECIFIC
SEPTIN-3

(Homo sapiens) 		PF00735
(Septin) 		4 LEU A  77
SER A  84
VAL A 123
PHE A  62
 None
 0.99A 4wnvD-3sopA:
undetectable		 4wnvD-3sopA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LEU A 478
GLU A 484
SER A 349
VAL A 488
 None
 1.02A 4wnvD-3sqwA:
undetectable		 4wnvD-3sqwA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t02 PHOSPHONOACETATE
HYDROLASE

(Sinorhizobium
meliloti) 		PF01663
(Phosphodiest) 		4 PHE A 231
LEU A  48
THR A 209
VAL A 247
 None
 1.06A 4wnvD-3t02A:
undetectable		 4wnvD-3t02A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u44 ATP-DEPENDENT
HELICASE/NUCLEASE
SUBUNIT A

(Bacillus
subtilis) 		PF00580
(UvrD-helicase)
PF12705
(PDDEXK_1)
PF13361
(UvrD_C) 		4 PHE A 150
LEU A 149
THR A 169
VAL A 181
 None
 0.90A 4wnvD-3u44A:
undetectable		 4wnvD-3u44A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v8d CHOLESTEROL
7-ALPHA-MONOOXYGENAS
E

(Homo sapiens) 		PF00067
(p450) 		4 PHE A 449
LEU A 133
SER A 140
PHE A 188
 None
HEM  A 601 (-4.4A)
None
None
 1.05A 4wnvD-3v8dA:
27.4		 4wnvD-3v8dA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9u PUTATIVE LIPASE

(Proteus
mirabilis) 		PF00561
(Abhydrolase_1) 		4 PHE A  60
LEU A  57
VAL A   8
PHE A  25
 None
 0.98A 4wnvD-3w9uA:
undetectable		 4wnvD-3w9uA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acq ALPHA-2-MACROGLOBULI
N

(Homo sapiens) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 PHE A 155
LEU A 778
SER A 532
VAL A 618
 None
 1.05A 4wnvD-4acqA:
undetectable		 4wnvD-4acqA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cg4 PYRIN

(Homo sapiens) 		PF00622
(SPRY)
PF13765
(PRY) 		4 PHE A 613
LEU A 617
GLU A 605
VAL A 642
 None
 0.92A 4wnvD-4cg4A:
undetectable		 4wnvD-4cg4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00271
(Helicase_C) 		4 LEU A 478
GLU A 484
SER A 349
VAL A 488
 None
 0.98A 4wnvD-4db4A:
undetectable		 4wnvD-4db4A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dji PROBABLE
GLUTAMATE/GAMMA-AMIN
OBUTYRATE ANTIPORTER

(Escherichia
coli) 		PF13520
(AA_permease_2) 		4 PHE A 210
GLU A  31
SER A 249
VAL A 206
 None
 1.06A 4wnvD-4djiA:
undetectable		 4wnvD-4djiA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc2 POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Mus musculus) 		PF05028
(PARG_cat) 		4 PHE A 910
LEU A 911
VAL A 953
PHE A 948
 None
 0.84A 4wnvD-4fc2A:
undetectable		 4wnvD-4fc2A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4joc LYSOPHOSPHATIDIC
ACID PHOSPHATASE
TYPE 6

(Homo sapiens) 		PF00328
(His_Phos_2) 		4 LEU A 407
GLU A 295
SER A 210
THR A 215
 None
 1.06A 4wnvD-4jocA:
undetectable		 4wnvD-4jocA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 PHE A 307
LEU A 308
GLU A 331
VAL A 328
 None
 1.01A 4wnvD-4k11A:
undetectable		 4wnvD-4k11A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kds PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Oncorhynchus
mykiss) 		PF00079
(Serpin) 		4 PHE A  17
LEU A 248
VAL A 241
PHE A 352
 None
 0.99A 4wnvD-4kdsA:
undetectable		 4wnvD-4kdsA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lmo TELOMERASE REVERSE
TRANSCRIPTASE

(Takifugu
rubripes) 		PF12009
(Telomerase_RBD) 		4 PHE A 445
LEU A 446
VAL A 504
PHE A 502
 None
 1.05A 4wnvD-4lmoA:
undetectable		 4wnvD-4lmoA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxi MCP HYDROLASE

(Sphingomonas
wittichii) 		PF12697
(Abhydrolase_6) 		4 PHE A  90
LEU A  87
VAL A  29
PHE A  44
 None
 1.01A 4wnvD-4lxiA:
undetectable		 4wnvD-4lxiA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o26 TELOMERASE REVERSE
TRANSCRIPTASE

(Oryzias latipes) 		PF12009
(Telomerase_RBD) 		4 PHE A 461
LEU A 462
VAL A 521
PHE A 519
 None
 1.07A 4wnvD-4o26A:
undetectable		 4wnvD-4o26A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p74 PHENYLALANINE--TRNA
LIGASE ALPHA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01409
(tRNA-synt_2d) 		4 PHE C 156
LEU C 160
THR C  33
VAL C 201
 None
 1.05A 4wnvD-4p74C:
undetectable		 4wnvD-4p74C:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE

(Chlamydia
trachomatis) 		PF00595
(PDZ)
PF03572
(Peptidase_S41) 		4 LEU A  70
SER A  77
THR A  85
VAL A  60
 None
 1.04A 4wnvD-4ql6A:
undetectable		 4wnvD-4ql6A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcm METHYLATED
RNA-BINDING PROTEIN
1

(Saccharomyces
cerevisiae) 		PF04146
(YTH) 		4 LEU A 149
GLU A 217
SER A 155
VAL A 215
 None
 0.87A 4wnvD-4rcmA:
undetectable		 4wnvD-4rcmA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnl POSSIBLE GALACTOSE
MUTAROTASE

(Streptomyces
platensis) 		PF01263
(Aldose_epim) 		4 PHE A 116
LEU A  78
THR A 172
VAL A 149
 None
 0.91A 4wnvD-4rnlA:
undetectable		 4wnvD-4rnlA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LEU A 478
GLU A 484
SER A 349
VAL A 488
 None
 1.06A 4wnvD-4tz0A:
undetectable		 4wnvD-4tz0A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wlh KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		4 PHE A  80
LEU A  84
GLU A 214
THR A 248
 None
None
None
LLP  A 247 ( 4.3A)
 1.02A 4wnvD-4wlhA:
undetectable		 4wnvD-4wlhA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wp0 KYNURENINE--OXOGLUTA
RATE TRANSAMINASE 1

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		4 PHE A  80
LEU A  84
GLU A 214
THR A 248
 None
None
None
LLP  A 247 ( 4.3A)
 0.98A 4wnvD-4wp0A:
undetectable		 4wnvD-4wp0A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxt FUSION OF PREDICTED
ZN-DEPENDENT
AMIDASE/PEPTIDASE
(CELL WALL
HYDROLASE/DD-CARBOXY
PEPTIDASE FAMILY)
AND UNCHARACTERIZED
DOMAIN OF ERFK
FAMILY
PEPTODOGLYCAN-BINDIN
G DOMAIN

(Clostridium
acetobutylicum) 		PF01471
(PG_binding_1)
PF03734
(YkuD) 		4 PHE A  86
SER A  89
VAL A 109
PHE A  97
 None
 0.95A 4wnvD-4xxtA:
undetectable		 4wnvD-4xxtA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzf FAB FRAGMENT OF
IMMUNOGLOBULIN (IGG)
MOLECULE

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 PHE E  24
LEU E   4
THR E  30
VAL E  36
 None
 1.02A 4wnvD-4yzfE:
undetectable		 4wnvD-4yzfE:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0z CHOLINE
TRIMETHYLAMINE LYASE

(Klebsiella
pneumoniae) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 GLU A 867
SER A 777
THR A 499
VAL A 883
 None
 1.06A 4wnvD-5a0zA:
undetectable		 4wnvD-5a0zA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3m ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA1

(Lactobacillus
delbrueckii) 		PF00005
(ABC_tran) 		4 PHE A  28
LEU A  26
THR A  36
VAL A  49
 None
 0.78A 4wnvD-5d3mA:
undetectable		 4wnvD-5d3mA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eco JASMONIC ACID-AMIDO
SYNTHETASE JAR1

(Arabidopsis
thaliana) 		PF03321
(GH3) 		4 PHE A  17
THR A 416
VAL A 341
PHE A 352
 None
 1.02A 4wnvD-5ecoA:
undetectable		 4wnvD-5ecoA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ei0 SERPIN A12

(Homo sapiens) 		PF00079
(Serpin) 		4 PHE A 272
LEU A 260
THR A 365
VAL A 308
 None
 0.61A 4wnvD-5ei0A:
undetectable		 4wnvD-5ei0A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvm ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Aspergillus
fumigatus) 		PF00982
(Glyco_transf_20) 		4 PHE A 304
LEU A 301
THR A 441
VAL A 315
 None
 0.89A 4wnvD-5hvmA:
undetectable		 4wnvD-5hvmA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ica PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF04003
(Utp12) 		4 LEU A 849
SER A 856
THR A 898
VAL A 881
 None
 1.02A 4wnvD-5icaA:
undetectable		 4wnvD-5icaA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT ALPHA

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		4 PHE L 233
LEU L 418
VAL L 439
PHE L 244
 None
 1.00A 4wnvD-5jfcL:
undetectable		 4wnvD-5jfcL:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbp GLYCOSYL HYDROLASE,
FAMILY 38

(Enterococcus
faecalis) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 PHE A 553
LEU A 556
THR A 549
VAL A 725
 None
 1.05A 4wnvD-5kbpA:
undetectable		 4wnvD-5kbpA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2p ARYLESTERASE

(Sulfolobus
solfataricus) 		PF07859
(Abhydrolase_3) 		4 PHE A 153
GLU A  94
SER A  98
VAL A 182
 None
 0.96A 4wnvD-5l2pA:
undetectable		 4wnvD-5l2pA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8s AMINO ACYL PEPTIDASE

(Sporosarcina
psychrophila) 		PF00326
(Peptidase_S9) 		4 PHE A 183
GLU A 153
THR A 136
PHE A 133
 None
 1.06A 4wnvD-5l8sA:
undetectable		 4wnvD-5l8sA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
1

(Bos taurus;
Bos taurus) 		PF00507
(Oxidored_q4)
PF00146
(NADHdh) 		5 LEU H 298
GLU A  68
SER A 101
THR A  61
VAL H 144
 None
 1.24A 4wnvD-5lc5H:
undetectable		 4wnvD-5lc5H:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lsk PROTEIN MIS12
HOMOLOG
POLYAMINE-MODULATED
FACTOR 1

(Homo sapiens;
Homo sapiens) 		PF05859
(Mis12)
PF03980
(Nnf1) 		4 PHE A 174
LEU B 190
SER A 172
PHE A 159
 None
 1.06A 4wnvD-5lskA:
undetectable		 4wnvD-5lskA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6y NITROGENASE
VANADIUM-IRON
PROTEIN BETA CHAIN

(Azotobacter
vinelandii) 		no annotation 4 PHE E 205
LEU E 201
THR E 297
VAL E 188
 None
 1.01A 4wnvD-5n6yE:
undetectable		 4wnvD-5n6yE:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfj MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1

(Homo sapiens) 		no annotation 4 PHE A 282
SER A 277
THR A 274
PHE A 207
 None
 0.75A 4wnvD-5nfjA:
undetectable		 4wnvD-5nfjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5owo CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		no annotation 4 LEU A  56
SER A  60
VAL A  27
PHE A  68
 None
 0.87A 4wnvD-5owoA:
undetectable		 4wnvD-5owoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdg FUSION GLYCOPROTEIN
F0,FIBRITIN

(Bovine
orthopneumovirus;
Enterobacteria
phage T4 sensu
lato) 		PF00523
(Fusion_gly)
PF07921
(Fibritin_C) 		4 LEU A 260
SER A 285
THR A 244
VAL A  57
 None
 1.04A 4wnvD-5tdgA:
undetectable		 4wnvD-5tdgA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uan RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		no annotation 4 PHE A 439
LEU A 436
VAL A 265
PHE A 346
 None
9CR  A 503 ( 4.8A)
None
None
 1.04A 4wnvD-5uanA:
undetectable		 4wnvD-5uanA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE

(Hypericum
androsaemum) 		no annotation 4 PHE A 291
LEU A 294
SER A 301
VAL A 387
 None
 1.05A 4wnvD-5ucoA:
undetectable		 4wnvD-5ucoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue7 PHOSPHOMANNOMUTASE

(Candida
albicans) 		PF03332
(PMM) 		4 PHE A 249
LEU A 245
VAL A  13
PHE A 210
 None
 0.81A 4wnvD-5ue7A:
undetectable		 4wnvD-5ue7A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf3 MAJOR CAPSID PROTEIN

(Escherichia
virus T4) 		PF07068
(Gp23) 		5 PHE A 404
SER A 388
THR A 391
VAL A 423
PHE A 434
 None
 1.46A 4wnvD-5vf3A:
undetectable		 4wnvD-5vf3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwl CENTROMERE PROTEIN
MIS12

(Schizosaccharomyces
pombe) 		no annotation 4 LEU M 154
SER M 213
THR M 164
PHE M 171
 None
 1.04A 4wnvD-5wwlM:
undetectable		 4wnvD-5wwlM:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wwp ORF1AB

(Middle East
respiratory
syndrome-related
coronavirus) 		no annotation 4 PHE B 291
SER B 264
VAL B 280
PHE B 437
 None
 0.93A 4wnvD-5wwpB:
undetectable		 4wnvD-5wwpB:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xb7 BETA-GALACTOSIDASE

(Bifidobacterium
animalis) 		no annotation 4 LEU A 391
THR A 699
VAL A 694
PHE A 658
 None
 0.85A 4wnvD-5xb7A:
undetectable		 4wnvD-5xb7A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bca A-KINASE ANCHOR
PROTEIN 13

(Homo sapiens) 		no annotation 4 PHE A2261
LEU A2274
VAL A2313
PHE A2299
 None
 0.97A 4wnvD-6bcaA:
undetectable		 4wnvD-6bcaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A 619
LEU A 618
SER A 629
VAL A 592
 None
 1.01A 4wnvD-6emkA:
undetectable		 4wnvD-6emkA:
undetectable