SIMILAR PATTERNS OF AMINO ACIDS FOR 4WNV_A_QI9A602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Leishmania
mexicana) 		PF00274
(Glycolytic) 		5 PHE A 337
LEU A 338
GLU A  79
VAL A  85
LEU A 106
 None
 1.24A 4wnvA-1epxA:
0.0		 4wnvA-1epxA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f75 UNDECAPRENYL
PYROPHOSPHATE
SYNTHETASE

(Micrococcus
luteus) 		PF01255
(Prenyltransf) 		5 PHE A 144
THR A  57
VAL A 108
VAL A 110
LEU A 140
 None
 1.05A 4wnvA-1f75A:
0.0		 4wnvA-1f75A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iid PEPTIDE
N-MYRISTOYLTRANSFERA
SE

(Saccharomyces
cerevisiae) 		PF01233
(NMT)
PF02799
(NMT_C) 		5 THR A 183
VAL A 173
VAL A 137
PHE A 148
LEU A 171
 NHM  A 500 (-3.7A)
NHM  A 500 (-4.3A)
None
None
NHM  A 500 (-4.1A)
 1.50A 4wnvA-1iidA:
0.0		 4wnvA-1iidA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kaw SINGLE-STRANDED DNA
BINDING PROTEIN

(Escherichia
coli) 		PF00436
(SSB) 		5 LEU A  14
THR A 108
VAL A 103
VAL A  57
LEU A  63
 None
 1.25A 4wnvA-1kawA:
undetectable		 4wnvA-1kawA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r3d CONSERVED
HYPOTHETICAL PROTEIN
VC1974

(Vibrio cholerae) 		PF12697
(Abhydrolase_6) 		5 SER A   3
THR A  74
VAL A  19
VAL A  21
LEU A  46
 None
 1.46A 4wnvA-1r3dA:
2.1		 4wnvA-1r3dA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rwr FILAMENTOUS
HEMAGGLUTININ

(Bordetella
pertussis) 		PF05860
(Haemagg_act) 		5 PHE A 160
LEU A 157
VAL A 111
VAL A 152
LEU A  88
 None
 1.22A 4wnvA-1rwrA:
undetectable		 4wnvA-1rwrA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2az4 HYPOTHETICAL PROTEIN
EF2904

(Enterococcus
faecalis) 		PF12706
(Lactamase_B_2) 		5 PHE A 258
LEU A 244
VAL A 297
VAL A 279
LEU A 289
 None
 1.27A 4wnvA-2az4A:
0.0		 4wnvA-2az4A:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 PHE A 405
LEU A 401
VAL A 389
VAL A 391
LEU A 345
 None
 1.30A 4wnvA-2cb1A:
0.0		 4wnvA-2cb1A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkd PHOSPHOACETYLGLUCOSA
MINE MUTASE

(Candida
albicans) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		5 PHE A 156
SER A 149
VAL A 135
PHE A 167
LEU A 175
 None
 1.39A 4wnvA-2dkdA:
0.0		 4wnvA-2dkdA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5t ARCHAEAL
TRANSCRIPTIONAL
REGULATOR TRMB

(Thermococcus
litoralis) 		PF11495
(Regulator_TrmB) 		5 PHE X 124
SER X 127
THR X 154
VAL X 161
VAL X 137
 None
 1.36A 4wnvA-2f5tX:
undetectable		 4wnvA-2f5tX:
18.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 121
SER A 304
THR A 309
PHE A 483
LEU A 484
 None
None
HEM  A 600 (-3.5A)
None
None
 1.48A 4wnvA-2f9qA:
54.4		 4wnvA-2f9qA:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		5 PHE A 120
LEU A 121
GLU A 216
SER A 304
THR A 309
 HEM  A 600 (-4.6A)
None
None
None
HEM  A 600 (-3.5A)
 1.02A 4wnvA-2f9qA:
54.4		 4wnvA-2f9qA:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		6 PHE A 120
LEU A 121
SER A 304
THR A 309
VAL A 370
LEU A 484
 HEM  A 600 (-4.6A)
None
None
HEM  A 600 (-3.5A)
HEM  A 600 ( 4.9A)
None
 0.66A 4wnvA-2f9qA:
54.4		 4wnvA-2f9qA:
99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jlp EXTRACELLULAR
SUPEROXIDE DISMUTASE
(CU-ZN)

(Homo sapiens) 		PF00080
(Sod_Cu) 		5 PHE A  84
SER A 137
VAL A  47
VAL A 162
PHE A  79
 None
 1.25A 4wnvA-2jlpA:
undetectable		 4wnvA-2jlpA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l01 UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF10771
(DUF2582) 		5 PHE A  42
LEU A  36
THR A  57
VAL A  55
LEU A  50
 None
 1.43A 4wnvA-2l01A:
undetectable		 4wnvA-2l01A:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2muk AUXIN-RESPONSIVE
PROTEIN IAA17

(Arabidopsis
thaliana) 		PF02309
(AUX_IAA) 		5 PHE X 145
LEU X 208
SER X 138
VAL X 115
LEU X 128
 None
 1.37A 4wnvA-2mukX:
undetectable		 4wnvA-2mukX:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyp BETA-LACTAMASE II

(Bacillus cereus) 		PF00753
(Lactamase_B) 		5 LEU A  98
SER A 107
THR A 142
VAL A 140
LEU A 133
 None
 1.44A 4wnvA-2nypA:
undetectable		 4wnvA-2nypA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rt5 MSX2-INTERACTING
PROTEIN

(Homo sapiens) 		PF07744
(SPOC) 		5 PHE A3634
SER A3637
VAL A3660
VAL A3563
LEU A3575
 None
 1.40A 4wnvA-2rt5A:
undetectable		 4wnvA-2rt5A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		5 LEU A 282
THR A 232
VAL A 269
PHE A 217
LEU A 213
 None
 1.37A 4wnvA-2z7xA:
undetectable		 4wnvA-2z7xA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zie PUTATIVE
MODIFICATION
METHYLASE

(Thermus
thermophilus) 		PF01555
(N6_N4_Mtase) 		5 PHE A 243
SER A  47
VAL A  83
VAL A  79
LEU A  93
 None
 1.17A 4wnvA-2zieA:
undetectable		 4wnvA-2zieA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1f CYTOCHROME B-245
HEAVY CHAIN

(Homo sapiens) 		PF08030
(NAD_binding_6) 		5 PHE A 136
SER A 163
VAL A  23
PHE A 151
LEU A 152
 None
 1.49A 4wnvA-3a1fA:
undetectable		 4wnvA-3a1fA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE

(Arthrobacter
sp. KI72) 		PF01425
(Amidase) 		5 LEU A 419
SER A 313
VAL A 430
VAL A 426
LEU A 366
 None
 1.34A 4wnvA-3a2qA:
undetectable		 4wnvA-3a2qA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clh 3-DEHYDROQUINATE
SYNTHASE

(Helicobacter
pylori) 		PF01761
(DHQ_synthase) 		5 PHE A 284
LEU A 286
VAL A 202
VAL A 172
LEU A 186
 None
 1.37A 4wnvA-3clhA:
undetectable		 4wnvA-3clhA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3el6 ERYTHROMYCIN
DEHYDRATASE

(Saccharopolyspora
erythraea) 		PF14765
(PS-DH) 		5 LEU A 204
SER A  55
VAL A 269
VAL A 258
LEU A 272
 None
 1.43A 4wnvA-3el6A:
undetectable		 4wnvA-3el6A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hum PENICILLIN-BINDING
PROTEIN 4

(Staphylococcus
aureus) 		PF00768
(Peptidase_S11)
PF09211
(DUF1958) 		5 PHE A 158
LEU A 161
THR A 135
VAL A 151
LEU A 132
 None
 1.37A 4wnvA-3humA:
undetectable		 4wnvA-3humA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Enterococcus
faecalis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 PHE A 120
LEU A 309
SER A 285
VAL A  63
VAL A 169
 None
None
None
None
CSO  A  13 ( 3.6A)
 1.32A 4wnvA-3il4A:
undetectable		 4wnvA-3il4A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m3i PUTATIVE
UNCHARACTERIZED
PROTEIN

(Leishmania
major) 		PF06172
(Cupin_5) 		5 GLU A  74
SER A  65
VAL A 128
VAL A 166
LEU A  86
 None
 1.41A 4wnvA-3m3iA:
undetectable		 4wnvA-3m3iA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0k ALDO/KETO REDUCTASE

(Brucella
abortus) 		PF00248
(Aldo_ket_red) 		5 PHE A 109
SER A 112
THR A 118
VAL A 152
LEU A  91
 None
 1.21A 4wnvA-3o0kA:
undetectable		 4wnvA-3o0kA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qph TRMB, A GLOBAL
TRANSCRIPTION
REGULATOR

(Pyrococcus
furiosus) 		PF01978
(TrmB)
PF11495
(Regulator_TrmB) 		5 PHE A 124
SER A 127
THR A 154
VAL A 161
VAL A 137
 None
GOL  A 411 (-3.9A)
ACT  A 402 (-4.4A)
None
None
 1.35A 4wnvA-3qphA:
undetectable		 4wnvA-3qphA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruy ORNITHINE
AMINOTRANSFERASE

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		5 LEU A 176
THR A 187
VAL A 221
VAL A 215
PHE A 223
 None
 1.26A 4wnvA-3ruyA:
undetectable		 4wnvA-3ruyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rxy NIF3 PROTEIN

(Sphaerobacter
thermophilus) 		no annotation 5 LEU A 102
GLU A 230
VAL A 221
VAL A 209
LEU A 242
 FMT  A 279 ( 4.5A)
None
None
None
None
 1.45A 4wnvA-3rxyA:
undetectable		 4wnvA-3rxyA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcs RACEMASE, PUTATIVE

(Roseobacter
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  63
THR A  21
VAL A  19
VAL A  85
LEU A  92
 None
 1.41A 4wnvA-3tcsA:
undetectable		 4wnvA-3tcsA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azv WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		5 PHE A 390
GLU A 396
VAL A 357
VAL A 352
LEU A 316
 None
 1.33A 4wnvA-4azvA:
1.8		 4wnvA-4azvA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4giw RUN AND SH3
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF02759
(RUN) 		5 PHE A 137
LEU A 140
SER A 168
VAL A  15
LEU A  12
 None
 1.43A 4wnvA-4giwA:
1.4		 4wnvA-4giwA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N) 		5 PHE L 425
LEU L 355
GLU L 437
VAL L 339
LEU L 443
 None
 1.32A 4wnvA-4heaL:
1.9		 4wnvA-4heaL:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kma GM14141P

(Drosophila
melanogaster) 		PF05076
(SUFU)
PF12470
(SUFU_C) 		5 PHE A 372
VAL A 354
VAL A 265
PHE A 269
LEU A 350
 None
 1.34A 4wnvA-4kmaA:
undetectable		 4wnvA-4kmaA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ll6 MYOSIN-4

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		5 LEU A1226
SER A1164
THR A1115
VAL A1147
LEU A1111
 None
 1.42A 4wnvA-4ll6A:
undetectable		 4wnvA-4ll6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0g PROTEIN PHOSPHATASE
2C 37

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		5 LEU A 346
THR A 370
VAL A 384
VAL A 386
LEU A 329
 None
 1.35A 4wnvA-4n0gA:
undetectable		 4wnvA-4n0gA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4no0 LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 1

(Homo sapiens) 		PF13895
(Ig_2) 		5 SER D 109
THR D 119
VAL D 161
VAL D 164
LEU D 120
 None
 1.40A 4wnvA-4no0D:
undetectable		 4wnvA-4no0D:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nre ARACHIDONATE
15-LIPOXYGENASE B

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 PHE A 365
LEU A 570
VAL A 426
VAL A 603
LEU A 420
 None
None
C8E  A 702 ( 4.0A)
C8E  A 702 ( 4.1A)
C8E  A 702 (-3.6A)
 1.29A 4wnvA-4nreA:
1.3		 4wnvA-4nreA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl9 ETHYLENE RECEPTOR 1

(Arabidopsis
thaliana) 		PF02518
(HATPase_c) 		5 PHE A 423
LEU A 443
VAL A 579
VAL A 509
LEU A 581
 None
 1.42A 4wnvA-4pl9A:
1.2		 4wnvA-4pl9A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C

(Zea mays) 		PF00171
(Aldedh) 		5 PHE A 319
LEU A 284
THR A 295
VAL A 276
VAL A 278
 None
 1.36A 4wnvA-4pxlA:
undetectable		 4wnvA-4pxlA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r12 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Dictyostelium
purpureum) 		PF05450
(Nicastrin) 		5 LEU A 398
GLU A 342
SER A 405
VAL A 415
LEU A 234
 None
 1.16A 4wnvA-4r12A:
undetectable		 4wnvA-4r12A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv0 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE
TER94

(Drosophila
melanogaster) 		PF02359
(CDC48_N)
PF02933
(CDC48_2) 		5 LEU A  48
THR A  64
VAL A  85
VAL A  36
LEU A  89
 None
 1.28A 4wnvA-4rv0A:
undetectable		 4wnvA-4rv0A:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxx UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 38

(Homo sapiens) 		no annotation 5 PHE A  80
LEU A 111
THR A  46
VAL A  85
LEU A  50
 None
 1.49A 4wnvA-4rxxA:
undetectable		 4wnvA-4rxxA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuk PUTATIVE HYDROLASE

(Acinetobacter
sp. NBRC 100985) 		PF00753
(Lactamase_B) 		5 PHE A 236
LEU A 152
THR A 255
VAL A  61
VAL A 110
 None
 1.45A 4wnvA-4xukA:
undetectable		 4wnvA-4xukA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg8 CHITIN BIOSYNTHESIS
PROTEIN CHS5

(Saccharomyces
cerevisiae) 		PF00533
(BRCT)
PF16893
(fn3_2) 		5 PHE A 274
SER A 188
VAL A 176
VAL A 245
LEU A 204
 None
 1.16A 4wnvA-4yg8A:
undetectable		 4wnvA-4yg8A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5afd N-ACETYLNEURAMINATE
LYASE

(Aliivibrio
salmonicida) 		PF00701
(DHDPS) 		5 LEU A 165
GLU A 174
SER A 169
VAL A 202
LEU A 172
 None
 1.49A 4wnvA-5afdA:
undetectable		 4wnvA-5afdA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5euf PROTEASE

(Helicobacter
pylori) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 PHE A 238
LEU A  38
VAL A  58
VAL A 219
LEU A 127
 None
 1.20A 4wnvA-5eufA:
0.2		 4wnvA-5eufA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey0 GTP-SENSING
TRANSCRIPTIONAL
PLEIOTROPIC
REPRESSOR CODY

(Staphylococcus
aureus) 		no annotation 5 LEU B  14
THR B  35
VAL B  39
VAL B  27
LEU B 128
 None
 1.43A 4wnvA-5ey0B:
undetectable		 4wnvA-5ey0B:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gaf SIGNAL RECOGNITION
PARTICLE PROTEIN

(Escherichia
coli) 		PF00466
(Ribosomal_L10) 		5 THR i 266
VAL i 245
VAL i 221
PHE i 236
LEU i 242
 None
 1.35A 4wnvA-5gafi:
undetectable		 4wnvA-5gafi:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jpn COMPLEMENT C4-A

(Homo sapiens) 		PF00207
(A2M)
PF01821
(ANATO)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 PHE B1360
SER B1341
VAL B 980
VAL B 978
LEU B1344
 None
 1.42A 4wnvA-5jpnB:
2.0		 4wnvA-5jpnB:
20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vbu CYTOCHROME P450
21-HYDROXYLASE

(Homo sapiens) 		PF00067
(p450) 		5 PHE A 165
LEU A 168
VAL A 479
PHE A 450
LEU A 452
 None
 1.22A 4wnvA-5vbuA:
39.4		 4wnvA-5vbuA:
32.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vf3 MAJOR CAPSID PROTEIN

(Escherichia
virus T4) 		PF07068
(Gp23) 		5 PHE A 404
SER A 388
THR A 391
VAL A 423
LEU A 354
 None
 1.15A 4wnvA-5vf3A:
undetectable		 4wnvA-5vf3A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wd6 SHORT PALATE, LUNG
AND NASAL EPITHELIUM
CARCINOMA-ASSOCIATED
PROTEIN 2B

(Bos taurus) 		no annotation 5 LEU A  42
SER A 207
VAL A 133
VAL A 103
LEU A 148
 None
 1.28A 4wnvA-5wd6A:
undetectable		 4wnvA-5wd6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y1a -

(-) 		no annotation 5 PHE A 229
LEU A 159
THR A  55
VAL A 187
LEU A 164
 None
 1.08A 4wnvA-5y1aA:
undetectable		 4wnvA-5y1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dgi D-ALANINE--D-ALANINE
LIGASE

(Vibrio cholerae) 		no annotation 5 SER A 143
VAL A 196
VAL A 194
PHE A 136
LEU A 135
 None
 1.15A 4wnvA-6dgiA:
undetectable		 4wnvA-6dgiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Acanthamoeba
castellanii) 		no annotation 5 PHE A  51
LEU A  21
THR A 172
VAL A 109
LEU A 151
 None
 1.41A 4wnvA-6fwhA:
undetectable		 4wnvA-6fwhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ghd


(;
) 		no annotation
no annotation 		5 PHE D  39
LEU D  34
THR G  30
VAL D  51
LEU D  52
 None
 1.30A 4wnvA-6ghdD:
undetectable		 4wnvA-6ghdD:
undetectable