SIMILAR PATTERNS OF AMINO ACIDS FOR 4WNU_D_QDND602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)


(Thermotoga
maritima)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
5 PHE A 217
GLY A 251
LEU A 284
ALA A 213
ALA A 225
None
1.11A 4wnuD-1b3bA:
0.0
4wnuD-1b3bA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dex RHAMNOGALACTURONAN
ACETYLESTERASE


(Aspergillus
aculeatus)
PF13472
(Lipase_GDSL_2)
5 GLY A 125
PHE A 121
LEU A 120
ALA A  58
ASP A  59
None
1.30A 4wnuD-1dexA:
undetectable
4wnuD-1dexA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE


(Escherichia
coli)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
5 GLY A  63
PHE A  40
ALA A  54
ASP A  55
ALA A  59
None
1.33A 4wnuD-1gg4A:
0.0
4wnuD-1gg4A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htn TETRANECTIN

(Homo sapiens)
PF00059
(Lectin_C)
5 GLY A 105
GLU A 107
LEU A 172
SER A 156
ALA A 159
None
1.29A 4wnuD-1htnA:
0.0
4wnuD-1htnA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzf COMPLEMENT FACTOR
C4A


(Homo sapiens)
PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl)
5 LEU A1254
ALA A1263
ASP A1264
SER A1267
ALA A1268
None
1.18A 4wnuD-1hzfA:
1.2
4wnuD-1hzfA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE


(Thermus
thermophilus)
PF01293
(PEPCK_ATP)
5 GLY A 525
GLU A 523
PHE A 510
ALA A 514
ALA A 518
None
1.26A 4wnuD-1j3bA:
0.0
4wnuD-1j3bA:
24.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkw CYCLIN H

(Homo sapiens)
PF00134
(Cyclin_N)
PF16899
(Cyclin_C_2)
5 PHE A 194
LEU A 195
ALA A 216
SER A 220
ALA A 221
None
0.98A 4wnuD-1jkwA:
0.0
4wnuD-1jkwA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqo PHOSPHOENOLPYRUVATE
CARBOXYLASE


(Zea mays)
PF00311
(PEPcase)
5 PHE A 565
ALA A 569
ASP A 570
SER A 573
ALA A 574
None
1.10A 4wnuD-1jqoA:
0.0
4wnuD-1jqoA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jtd BETA-LACTAMASE
INHIBITOR PROTEIN II


(Streptomyces
exfoliatus)
PF13540
(RCC1_2)
5 GLY B 127
GLN B  94
LEU B  77
ALA B 110
ALA B 151
None
1.26A 4wnuD-1jtdB:
0.0
4wnuD-1jtdB:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qge PROTEIN
(TRIACYLGLYCEROL
HYDROLASE)


(Burkholderia
glumae)
PF00561
(Abhydrolase_1)
no annotation
5 GLY E 232
ALA E 300
ASP E 287
SER E 230
ALA D 213
None
None
CA  E 320 (-3.4A)
None
None
1.26A 4wnuD-1qgeE:
undetectable
4wnuD-1qgeE:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu6 PROTEIN KINASE PKR

(Homo sapiens)
PF00035
(dsrm)
5 PHE A  48
GLY A  13
LEU A  19
ALA A  73
ALA A  68
None
1.26A 4wnuD-1qu6A:
undetectable
4wnuD-1qu6A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si8 CATALASE

(Enterococcus
faecalis)
PF00199
(Catalase)
PF06628
(Catalase-rel)
5 PHE A 188
PHE A 313
LEU A 113
ALA A  90
ALA A  58
None
HEM  A 501 (-4.5A)
None
None
None
1.09A 4wnuD-1si8A:
undetectable
4wnuD-1si8A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svv THREONINE ALDOLASE

(Leishmania
major)
PF01212
(Beta_elim_lyase)
5 GLY A 270
PHE A 266
LEU A 260
ALA A 214
ALA A 185
None
1.26A 4wnuD-1svvA:
undetectable
4wnuD-1svvA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6p PHENYLALANINE
AMMONIA-LYASE


(Rhodotorula
toruloides)
PF00221
(Lyase_aromatic)
5 GLU A 671
LEU A 658
ALA A 654
ASP A 536
SER A 652
None
1.22A 4wnuD-1t6pA:
3.1
4wnuD-1t6pA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tah LIPASE

(Burkholderia
glumae)
no annotation 5 GLY B 232
ALA B 300
ASP B 287
SER B 230
ALA B 213
None
None
CA  B 320 ( 3.4A)
None
None
1.20A 4wnuD-1tahB:
undetectable
4wnuD-1tahB:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ted PKS18

(Mycobacterium
tuberculosis)
PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C)
5 GLY A 315
LEU A 352
ALA A 311
SER A 337
ALA A 334
GLY  A 315 ( 0.0A)
LEU  A 352 ( 0.6A)
ALA  A 311 ( 0.0A)
SER  A 337 ( 0.0A)
ALA  A 334 ( 0.0A)
1.26A 4wnuD-1tedA:
undetectable
4wnuD-1tedA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tn3 TETRANECTIN

(Homo sapiens)
PF00059
(Lectin_C)
5 GLY A 105
GLU A 107
LEU A 172
SER A 156
ALA A 159
None
1.23A 4wnuD-1tn3A:
undetectable
4wnuD-1tn3A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug3 EUKARYOTIC PROTEIN
SYNTHESIS INITIATION
FACTOR 4G


(Homo sapiens)
PF02020
(W2)
PF02847
(MA3)
5 GLY A1455
LEU A1448
ALA A1486
SER A1490
ALA A1491
None
0.88A 4wnuD-1ug3A:
undetectable
4wnuD-1ug3A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8d 2,4-DIENOYL-COA
REDUCTASE,
MITOCHONDRIAL
PRECURSOR


(Homo sapiens)
PF13561
(adh_short_C2)
5 PHE A  57
LEU A  82
ALA A 282
SER A 286
ALA A 289
GOL  A1329 ( 4.2A)
None
None
GOL  A1329 (-4.3A)
None
1.31A 4wnuD-1w8dA:
undetectable
4wnuD-1w8dA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wop AMINOMETHYLTRANSFERA
SE


(Thermotoga
maritima)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
5 PHE A  67
GLY A  91
GLU A  89
LEU A 271
ASP A 263
None
1.34A 4wnuD-1wopA:
undetectable
4wnuD-1wopA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN


(Thermus
thermophilus)
PF01409
(tRNA-synt_2d)
5 GLY A 281
PHE A 315
LEU A 233
ALA A 236
ALA A 241
None
1.36A 4wnuD-2amcA:
undetectable
4wnuD-2amcA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2g THREONINE SYNTHASE

(Arabidopsis
thaliana)
PF00291
(PALP)
5 PHE A 303
GLY A 295
LEU A 333
ALA A 368
ALA A 302
None
1.35A 4wnuD-2c2gA:
undetectable
4wnuD-2c2gA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfc 2-(R)-HYDROXYPROPYL-
COM DEHYDROGENASE


(Xanthobacter
autotrophicus)
PF13561
(adh_short_C2)
5 GLY A 186
LEU A 241
ALA A 224
ASP A 223
ALA A 219
KPC  A1252 (-4.7A)
None
None
None
None
1.13A 4wnuD-2cfcA:
undetectable
4wnuD-2cfcA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cir HEXOSE-6-PHOSPHATE
MUTAROTASE


(Saccharomyces
cerevisiae)
PF01263
(Aldose_epim)
5 GLY A 256
LEU A  44
ALA A  48
ASP A 250
ALA A 249
None
1.23A 4wnuD-2cirA:
undetectable
4wnuD-2cirA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0v METHANOL
DEHYDROGENASE LARGE
SUBUNIT


(Hyphomicrobium
denitrificans)
PF01011
(PQQ)
PF13360
(PQQ_2)
5 GLY A 428
GLN A 429
PHE A 430
SER A 100
ALA A  97
None
1.36A 4wnuD-2d0vA:
undetectable
4wnuD-2d0vA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t FATTY OXIDATION
COMPLEX ALPHA
SUBUNIT


(Pseudomonas
fragi)
PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
5 GLY A 148
GLU A 140
LEU A  85
ALA A 282
ALA A 251
None
1.28A 4wnuD-2d3tA:
undetectable
4wnuD-2d3tA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eid GALACTOSE OXIDASE

(Fusarium
graminearum)
PF00754
(F5_F8_type_C)
PF01344
(Kelch_1)
PF09118
(DUF1929)
5 PHE A 227
GLY A 288
GLN A 273
ALA A 247
SER A 291
CU  A 640 (-4.4A)
None
None
None
None
1.26A 4wnuD-2eidA:
undetectable
4wnuD-2eidA:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens)
PF00067
(p450)
5 PHE A 120
GLY A 212
GLN A 244
ASP A 301
ALA A 305
HEM  A 600 (-4.6A)
None
None
None
HEM  A 600 (-3.6A)
1.05A 4wnuD-2f9qA:
55.5
4wnuD-2f9qA:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens)
PF00067
(p450)
5 PHE A 120
GLY A 212
GLU A 216
GLN A 244
ALA A 305
HEM  A 600 (-4.6A)
None
None
None
HEM  A 600 (-3.6A)
1.27A 4wnuD-2f9qA:
55.5
4wnuD-2f9qA:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens)
PF00067
(p450)
5 PHE A 120
GLY A 212
GLU A 216
LEU A 251
ALA A 305
HEM  A 600 (-4.6A)
None
None
None
HEM  A 600 (-3.6A)
1.30A 4wnuD-2f9qA:
55.5
4wnuD-2f9qA:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens)
PF00067
(p450)
8 PHE A 120
GLY A 212
PHE A 247
LEU A 248
ALA A 300
ASP A 301
SER A 304
ALA A 305
HEM  A 600 (-4.6A)
None
None
None
None
None
None
HEM  A 600 (-3.6A)
0.53A 4wnuD-2f9qA:
55.5
4wnuD-2f9qA:
99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A


(Archaeoglobus
fulgidus)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
5 PHE A 257
GLY A 438
LEU A 108
ALA A 443
ALA A 402
None
FAD  A1000 (-3.5A)
None
None
None
1.29A 4wnuD-2fjaA:
undetectable
4wnuD-2fjaA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fsr ACETYLTRANSFERASE

(Agrobacterium
fabrum)
PF13302
(Acetyltransf_3)
5 PHE A 119
GLY A  94
ALA A 113
ASP A 116
ALA A 118
None
1.24A 4wnuD-2fsrA:
undetectable
4wnuD-2fsrA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdr GLUTATHIONE
S-TRANSFERASE


(Paraburkholderia
xenovorans)
PF02798
(GST_N)
PF13410
(GST_C_2)
5 GLY A 148
GLU A  90
ALA A 154
SER A 152
ALA A  83
None
1.10A 4wnuD-2gdrA:
undetectable
4wnuD-2gdrA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE


(Homo sapiens)
PF01729
(QRPTase_C)
PF02749
(QRPTase_N)
5 GLY A  58
GLN A  59
PHE A  62
ALA A  90
ALA A  50
None
1.18A 4wnuD-2jbmA:
undetectable
4wnuD-2jbmA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh3 RIBOSOMAL PROTEIN
S2-RELATED PROTEIN


(Deinococcus
radiodurans)
PF01903
(CbiX)
5 GLY A  52
GLU A  50
GLN A  55
ALA A 449
ALA A 451
None
None
None
None
SF4  A 650 ( 4.5A)
1.32A 4wnuD-2jh3A:
undetectable
4wnuD-2jh3A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oby PUTATIVE QUINONE
OXIDOREDUCTASE


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 GLY A  62
GLN A  95
LEU A 330
ALA A  36
ALA A 120
None
1.08A 4wnuD-2obyA:
undetectable
4wnuD-2obyA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oix XANTHOMONAS OUTER
PROTEIN D


(Xanthomonas
euvesicatoria)
PF02902
(Peptidase_C48)
5 PHE A 366
GLU A 479
LEU A 512
ALA A 346
ALA A 352
None
1.31A 4wnuD-2oixA:
undetectable
4wnuD-2oixA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p2c CASPASE-2

(Homo sapiens)
PF12796
(Ank_2)
PF13637
(Ank_4)
5 GLY P 124
LEU P 117
ALA P 149
SER P 153
ALA P 162
None
1.29A 4wnuD-2p2cP:
undetectable
4wnuD-2p2cP:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv5 UNCHARACTERIZED
PROTEIN ATU2773


(Agrobacterium
fabrum)
PF04748
(Polysacc_deac_2)
5 GLY A 315
GLN A 325
LEU A 304
ALA A 328
ASP A 329
None
1.29A 4wnuD-2qv5A:
undetectable
4wnuD-2qv5A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7s PROBABLE CONSERVED
LIPOPROTEIN LPPA


(Mycobacterium
tuberculosis)
PF16708
(LppA)
6 GLY A 127
PHE A 126
ALA A  78
ASP A  79
SER A  82
ALA A  83
GOL  A1208 (-3.3A)
None
None
None
None
None
0.99A 4wnuD-2v7sA:
undetectable
4wnuD-2v7sA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN


(Azospirillum
brasilense)
PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central)
5 GLY A 494
LEU A 658
ALA A 620
ASP A 608
ALA A 617
None
1.06A 4wnuD-2vdcA:
undetectable
4wnuD-2vdcA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 PHE A1276
LEU A1267
ALA A1114
ASP A1118
ALA A1121
None
1.27A 4wnuD-2z8cA:
undetectable
4wnuD-2z8cA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9x SELENOCYSTEINE LYASE

(Rattus
norvegicus)
PF00266
(Aminotran_5)
5 GLY A  75
LEU A  70
ALA A 297
ASP A 298
SER A 301
None
0.95A 4wnuD-3a9xA:
undetectable
4wnuD-3a9xA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq3 DEFECTIVE IN CULLIN
NEDDYLATION PROTEIN
1


(Saccharomyces
cerevisiae)
PF03556
(Cullin_binding)
PF14555
(UBA_4)
5 GLU A 198
GLN A 196
PHE A 194
ASP A 106
ALA A 108
None
1.36A 4wnuD-3bq3A:
undetectable
4wnuD-3bq3A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7t ECDYSTEROID-PHOSPHAT
E PHOSPHATASE


(Bombyx mori)
PF00300
(His_Phos_1)
5 GLY A 171
GLU A 141
PHE A 168
LEU A  78
ALA A 146
None
1.32A 4wnuD-3c7tA:
undetectable
4wnuD-3c7tA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djl PROTEIN AIDB

(Escherichia
coli)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
5 PHE A 114
GLY A 305
LEU A 123
ALA A 119
ALA A 359
None
1.33A 4wnuD-3djlA:
undetectable
4wnuD-3djlA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0w NUMB-LIKE PROTEIN

(Homo sapiens)
PF00640
(PID)
5 GLY A  86
LEU A 175
ALA A 156
ASP A 150
SER A 158
None
1.05A 4wnuD-3f0wA:
undetectable
4wnuD-3f0wA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1


(Homo sapiens)
PF00476
(DNA_pol_A)
5 PHE A 273
GLY A 431
PHE A 291
ASP A 274
ALA A 276
None
1.14A 4wnuD-3ikmA:
0.5
4wnuD-3ikmA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN ES26


(Plasmodium
falciparum)
PF01283
(Ribosomal_S26e)
5 PHE 3  83
GLY 3  27
LEU 3  21
ALA 3  35
ALA 3  78
None
1.08A 4wnuD-3j7a3:
undetectable
4wnuD-3j7a3:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kiz PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE


(Cytophaga
hutchinsonii)
PF02769
(AIRS_C)
5 GLY A 241
GLU A 242
GLN A 324
PHE A 217
ALA A 256
None
1.23A 4wnuD-3kizA:
undetectable
4wnuD-3kizA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6c SERINE RACEMASE

(Rattus
norvegicus)
PF00291
(PALP)
5 GLY A  88
GLN A  89
ALA A 110
ASP A 238
SER A  84
None
None
None
None
MLI  A 341 (-2.7A)
1.21A 4wnuD-3l6cA:
undetectable
4wnuD-3l6cA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9v FAD-DEPENDENT
OXIDOREDUCTASE


(Actinomadura
kijaniata)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 GLY A 253
ALA A 316
ASP A 317
SER A 320
ALA A 321
TYD  A 901 (-3.3A)
None
None
None
None
0.85A 4wnuD-3m9vA:
undetectable
4wnuD-3m9vA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq3 PYRUVATE
DEHYDROGENASE
PHOSPHATASE 1


(Bos taurus)
PF00481
(PP2C)
5 PHE A  41
GLY A  66
LEU A 213
ALA A 206
ALA A  58
None
0.98A 4wnuD-3mq3A:
undetectable
4wnuD-3mq3A:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1


(Sus scrofa)
PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase)
5 GLY A 950
GLU A 954
LEU A 815
ASP A 926
ALA A 925
None
1.26A 4wnuD-3n23A:
undetectable
4wnuD-3n23A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE


(Mycobacterium
tuberculosis)
PF00218
(IGPS)
5 GLY A  53
LEU A 229
ALA A 261
ASP A 257
ALA A 256
None
1.31A 4wnuD-3t44A:
undetectable
4wnuD-3t44A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE


(Oryza sativa)
PF00875
(DNA_photolyase)
5 GLY A 190
PHE A 188
LEU A 326
SER A 178
ALA A 179
None
1.19A 4wnuD-3umvA:
undetectable
4wnuD-3umvA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aip FE-REGULATED PROTEIN
B


(Neisseria
meningitidis)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
5 GLY A 652
LEU A 600
ALA A 602
SER A 639
ALA A 638
None
1.33A 4wnuD-4aipA:
undetectable
4wnuD-4aipA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnv AT5G63860/MGI19_6

(Arabidopsis
thaliana)
PF00415
(RCC1)
5 GLY A  40
GLN A 359
LEU A 341
ALA A  22
ALA A  76
None
1.31A 4wnuD-4dnvA:
undetectable
4wnuD-4dnvA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dok SIMILARITY TO
CHALCONE-FLAVONONE
ISOMERASE


(Arabidopsis
thaliana)
PF02431
(Chalcone)
5 PHE A  75
ALA A 201
ASP A 202
SER A 205
ALA A 206
None
0.99A 4wnuD-4dokA:
undetectable
4wnuD-4dokA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4g METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE


(Sinorhizobium
meliloti)
PF00171
(Aldedh)
5 PHE A 149
GLY A 320
GLU A 277
ALA A  96
ASP A  99
None
0.91A 4wnuD-4e4gA:
undetectable
4wnuD-4e4gA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eku PROTEIN-TYROSINE
KINASE 2-BETA


(Homo sapiens)
PF00373
(FERM_M)
5 GLY A 282
GLU A 263
LEU A 354
ASP A 346
ALA A 345
None
1.31A 4wnuD-4ekuA:
undetectable
4wnuD-4ekuA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl4 CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION


(Ruminiclostridium
thermocellum)
PF00963
(Cohesin)
5 GLY C 128
GLU C 137
ALA C  88
SER C  40
ALA C  39
None
1.27A 4wnuD-4fl4C:
undetectable
4wnuD-4fl4C:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hiz ENDOSIALIDASE

(Enterobacteria
phage phi92)
PF12217
(End_beta_propel)
PF12218
(End_N_terminal)
PF12219
(End_tail_spike)
5 PHE A 154
GLY A 181
GLU A 178
ALA A 157
ALA A 176
None
EDO  A 810 (-4.1A)
None
None
None
1.21A 4wnuD-4hizA:
undetectable
4wnuD-4hizA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcs ENOYL-COA
HYDRATASE/ISOMERASE


(Cupriavidus
metallidurans)
PF00378
(ECH_1)
5 GLY A 112
PHE A 130
ALA A 128
ASP A 105
ALA A 103
None
1.18A 4wnuD-4jcsA:
undetectable
4wnuD-4jcsA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpp PUTATIVE
UNCHARACTERIZED
PROTEIN


(Archaeoglobus
fulgidus)
PF01699
(Na_Ca_ex)
5 GLY A 217
PHE A 213
LEU A 212
ALA A  53
ALA A  74
None
1.27A 4wnuD-4kppA:
undetectable
4wnuD-4kppA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X

(Homo sapiens)
PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
5 PHE A 361
GLY A  90
LEU A  87
ALA A 339
ALA A 350
None
1.29A 4wnuD-4nenA:
undetectable
4wnuD-4nenA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ony EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 5


(Brucella
melitensis)
PF00496
(SBP_bac_5)
5 GLU A 374
ALA A 538
ASP A 539
SER A 542
ALA A 543
None
1.30A 4wnuD-4onyA:
undetectable
4wnuD-4onyA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otd SERINE/THREONINE-PRO
TEIN KINASE N1


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
5 GLY A 808
LEU A 815
ALA A 723
SER A 727
ALA A 728
None
0.64A 4wnuD-4otdA:
undetectable
4wnuD-4otdA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psd CARBOHYDRATE
ESTERASE FAMILY 5


(Trichoderma
reesei)
PF01083
(Cutinase)
5 GLY A 162
LEU A 209
ALA A 239
ASP A 235
ALA A 233
None
1.28A 4wnuD-4psdA:
undetectable
4wnuD-4psdA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE


(Streptomyces
platensis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 GLY A3045
PHE A3061
LEU A3058
ALA A3007
ALA A2997
None
1.18A 4wnuD-4qyrA:
undetectable
4wnuD-4qyrA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r72 ABC-TYPE FE3+
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT


(Actinobacillus
pleuropneumoniae)
PF13343
(SBP_bac_6)
5 GLY A 225
GLU A 224
LEU A 107
ALA A 154
ALA A 167
None
1.29A 4wnuD-4r72A:
undetectable
4wnuD-4r72A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3t PENICILLIN-BINDING
PROTEIN 2


(Neisseria
gonorrhoeae)
PF00905
(Transpeptidase)
5 PHE A 462
GLU A 385
ALA A 323
ASP A 322
ALA A 318
None
1.35A 4wnuD-4u3tA:
undetectable
4wnuD-4u3tA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT


(Pseudomonas
protegens)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 PHE A 424
GLY A 160
ALA A  52
SER A  56
ALA A  57
None
1.12A 4wnuD-5ahkA:
undetectable
4wnuD-5ahkA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT


(Squalus
acanthias)
PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase)
5 GLY A 957
GLU A 961
LEU A 822
ASP A 933
ALA A 932
None
1.32A 4wnuD-5aw4A:
undetectable
4wnuD-5aw4A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp1 MYCOCEROSIC ACID
SYNTHASE


(Mycolicibacterium
smegmatis)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 LEU A 508
ALA A 849
ASP A 850
SER A 853
ALA A 854
None
1.17A 4wnuD-5bp1A:
undetectable
4wnuD-5bp1A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6s INTEGRIN ALPHA-L

(Homo sapiens)
PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
5 GLY A  81
LEU A  25
ALA A  75
ASP A 332
ALA A 338
None
1.35A 4wnuD-5e6sA:
undetectable
4wnuD-5e6sA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo6 COPROPORPHYRINOGEN
OXIDASE


(Acinetobacter
baumannii)
PF01218
(Coprogen_oxidas)
5 PHE A 164
GLY A 136
PHE A 138
ALA A 157
ALA A 213
None
1.33A 4wnuD-5eo6A:
undetectable
4wnuD-5eo6A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eoe BETA-LACTAMASE

(Pseudomonas
aeruginosa)
PF13354
(Beta-lactamase2)
5 GLY A 108
LEU A  94
ALA A 126
ASP A 124
ALA A 115
None
1.26A 4wnuD-5eoeA:
undetectable
4wnuD-5eoeA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eov 16S/23S RRNA
(CYTIDINE-2'-O)-METH
YLTRANSFERASE TLYA


(Mycobacterium
tuberculosis)
PF01728
(FtsJ)
5 GLY A 114
LEU A 155
ALA A  89
ASP A  88
ALA A 110
None
1.14A 4wnuD-5eovA:
undetectable
4wnuD-5eovA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guj DNA PRIMASE

(Bacillus
subtilis)
PF08275
(Toprim_N)
PF10410
(DnaB_bind)
PF13155
(Toprim_2)
5 GLY A 149
ALA A 271
ASP A 272
SER A 275
ALA A 276
None
0.93A 4wnuD-5gujA:
undetectable
4wnuD-5gujA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5j FERREDOXIN--NADP
REDUCTASE


(Zea mays)
PF00175
(NAD_binding_1)
5 GLU A 162
PHE A 189
LEU A 185
ALA A 202
ALA A 167
None
1.28A 4wnuD-5h5jA:
undetectable
4wnuD-5h5jA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192


(Chaetomium
thermophilum)
PF11894
(Nup192)
5 GLY B 395
GLN B 398
ALA B 381
ASP B 382
ALA B 385
None
1.21A 4wnuD-5hb4B:
undetectable
4wnuD-5hb4B:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ht7 UNCHARACTERIZED
PROTEIN


(Methanothrix
thermoacetophila)
PF00030
(Crystall)
5 GLU A  49
GLN A  53
PHE A  52
ALA A  22
ASP A  23
None
1.14A 4wnuD-5ht7A:
undetectable
4wnuD-5ht7A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ht7 UNCHARACTERIZED
PROTEIN


(Methanothrix
thermoacetophila)
PF00030
(Crystall)
5 GLU A  49
GLN A  53
PHE A  52
ALA A  22
SER A  78
None
1.33A 4wnuD-5ht7A:
undetectable
4wnuD-5ht7A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jhe PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
CYP7


(Saccharomyces
cerevisiae)
PF00160
(Pro_isomerase)
PF00515
(TPR_1)
5 GLY A 247
GLU A 245
LEU A 298
SER A 266
ALA A 240
None
1.26A 4wnuD-5jheA:
undetectable
4wnuD-5jheA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj6 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB


(Aggregatibacter
actinomycetemcomitans)
no annotation 5 GLY A 132
GLU A 129
LEU A 144
ALA A 102
ALA A 124
None
1.24A 4wnuD-5lj6A:
0.0
4wnuD-5lj6A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ljo OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMA


(Escherichia
coli)
PF01103
(Bac_surface_Ag)
PF07244
(POTRA)
5 GLN A 803
PHE A 663
ASP A 740
SER A 769
ALA A 770
None
1.23A 4wnuD-5ljoA:
undetectable
4wnuD-5ljoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mjv CAPSID SUBUNIT VP0
CAPSID SUBUNIT VP1
CAPSID SUBUNIT VP3


(Parechovirus A)
PF00073
(Rhv)
no annotation
5 GLY B 182
GLU C 216
ASP A  38
SER A  35
ALA A  36
None
1.32A 4wnuD-5mjvB:
undetectable
4wnuD-5mjvB:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2i GLYCOSYLASPARAGINASE

(Elizabethkingia
meningoseptica)
PF01112
(Asparaginase_2)
5 GLY A 162
GLU A  72
LEU A  25
ALA A 157
ALA A 199
None
1.22A 4wnuD-5v2iA:
undetectable
4wnuD-5v2iA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbl REGULATORY-ASSOCIATE
D PROTEIN OF TOR 1


(Arabidopsis
thaliana)
no annotation 5 PHE A 440
PHE A 311
LEU A 308
ALA A 417
ALA A 412
None
1.31A 4wnuD-5wblA:
undetectable
4wnuD-5wblA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xao UNCHARACTERIZED
PROTEIN


(Parastagonospora
nodorum)
PF01266
(DAO)
5 LEU A  63
ALA A 351
ASP A 347
SER A 413
ALA A 410
None
1.35A 4wnuD-5xaoA:
undetectable
4wnuD-5xaoA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbk IMPORTIN-4

(Homo sapiens)
no annotation 5 PHE D 921
GLY D 930
GLU D 928
LEU D 941
ALA D 883
None
1.13A 4wnuD-5xbkD:
undetectable
4wnuD-5xbkD:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmg UNCHARACTERIZED
PROTEIN


(Pseudomonas
aeruginosa)
no annotation 5 GLY A  73
LEU A 255
ALA A 257
ASP A 261
ALA A 235
None
0.92A 4wnuD-5xmgA:
undetectable
4wnuD-5xmgA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ya1 AUTOINDUCER-2 KINASE

(Escherichia
coli)
no annotation 5 GLY A 103
LEU A 213
ALA A 215
SER A 219
ALA A 184
None
1.35A 4wnuD-5ya1A:
undetectable
4wnuD-5ya1A:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh0 DRFAM20C1

(Danio rerio)
no annotation 5 PHE A 299
GLY A 431
PHE A 459
ALA A 290
ASP A 294
None
1.24A 4wnuD-5yh0A:
undetectable
4wnuD-5yh0A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yh3 EXTRACELLULAR
SERINE/THREONINE
PROTEIN KINASE
FAM20C


(Homo sapiens)
no annotation 5 PHE C 323
GLY C 455
PHE C 483
ALA C 314
ASP C 318
None
1.26A 4wnuD-5yh3C:
undetectable
4wnuD-5yh3C:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zw4 PUTATIVE
O-METHYLTRANSFERASE
YRRM


(Bacillus
subtilis)
no annotation 5 GLY A 112
GLU A 116
PHE A 110
ALA A 120
ASP A 119
None
1.27A 4wnuD-5zw4A:
undetectable
4wnuD-5zw4A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cbo C-6'
AMINOTRANSFERASE


(Micromonospora
echinospora)
no annotation 5 GLY A 305
PHE A 301
ASP A 366
SER A 369
ALA A 370
None
1.19A 4wnuD-6cboA:
undetectable
4wnuD-6cboA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cip PYRUVATE-FERREDOXIN
OXIDOREDUCTASE


(Moorella
thermoacetica)
no annotation 5 GLY A  87
GLN A  86
ALA A 126
ASP A 124
ALA A 111
HTL  A1204 ( 4.6A)
None
None
None
None
1.36A 4wnuD-6cipA:
undetectable
4wnuD-6cipA:
12.63