SIMILAR PATTERNS OF AMINO ACIDS FOR 4WNU_D_QDND602
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b3b | PROTEIN (GLUTAMATEDEHYDROGENASE) (Thermotogamaritima) |
PF00208(ELFV_dehydrog)PF02812(ELFV_dehydrog_N) | 5 | PHE A 217GLY A 251LEU A 284ALA A 213ALA A 225 | None | 1.11A | 4wnuD-1b3bA:0.0 | 4wnuD-1b3bA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dex | RHAMNOGALACTURONANACETYLESTERASE (Aspergillusaculeatus) |
PF13472(Lipase_GDSL_2) | 5 | GLY A 125PHE A 121LEU A 120ALA A 58ASP A 59 | None | 1.30A | 4wnuD-1dexA:undetectable | 4wnuD-1dexA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gg4 | UDP-N-ACETYLMURAMOYLALANYL-D-GLUTAMYL-2,6-DIAMINOPIMELATE-D-ALANYL-D-ALANYLLIGASE (Escherichiacoli) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 5 | GLY A 63PHE A 40ALA A 54ASP A 55ALA A 59 | None | 1.33A | 4wnuD-1gg4A:0.0 | 4wnuD-1gg4A:24.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1htn | TETRANECTIN (Homo sapiens) |
PF00059(Lectin_C) | 5 | GLY A 105GLU A 107LEU A 172SER A 156ALA A 159 | None | 1.29A | 4wnuD-1htnA:0.0 | 4wnuD-1htnA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hzf | COMPLEMENT FACTORC4A (Homo sapiens) |
PF07678(A2M_comp)PF10569(Thiol-ester_cl) | 5 | LEU A1254ALA A1263ASP A1264SER A1267ALA A1268 | None | 1.18A | 4wnuD-1hzfA:1.2 | 4wnuD-1hzfA:23.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j3b | ATP-DEPENDENTPHOSPHOENOLPYRUVATECARBOXYKINASE (Thermusthermophilus) |
PF01293(PEPCK_ATP) | 5 | GLY A 525GLU A 523PHE A 510ALA A 514ALA A 518 | None | 1.26A | 4wnuD-1j3bA:0.0 | 4wnuD-1j3bA:24.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jkw | CYCLIN H (Homo sapiens) |
PF00134(Cyclin_N)PF16899(Cyclin_C_2) | 5 | PHE A 194LEU A 195ALA A 216SER A 220ALA A 221 | None | 0.98A | 4wnuD-1jkwA:0.0 | 4wnuD-1jkwA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jqo | PHOSPHOENOLPYRUVATECARBOXYLASE (Zea mays) |
PF00311(PEPcase) | 5 | PHE A 565ALA A 569ASP A 570SER A 573ALA A 574 | None | 1.10A | 4wnuD-1jqoA:0.0 | 4wnuD-1jqoA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jtd | BETA-LACTAMASEINHIBITOR PROTEIN II (Streptomycesexfoliatus) |
PF13540(RCC1_2) | 5 | GLY B 127GLN B 94LEU B 77ALA B 110ALA B 151 | None | 1.26A | 4wnuD-1jtdB:0.0 | 4wnuD-1jtdB:19.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qge | PROTEIN(TRIACYLGLYCEROLHYDROLASE) (Burkholderiaglumae) |
PF00561(Abhydrolase_1)no annotation | 5 | GLY E 232ALA E 300ASP E 287SER E 230ALA D 213 | NoneNone CA E 320 (-3.4A)NoneNone | 1.26A | 4wnuD-1qgeE:undetectable | 4wnuD-1qgeE:14.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qu6 | PROTEIN KINASE PKR (Homo sapiens) |
PF00035(dsrm) | 5 | PHE A 48GLY A 13LEU A 19ALA A 73ALA A 68 | None | 1.26A | 4wnuD-1qu6A:undetectable | 4wnuD-1qu6A:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1si8 | CATALASE (Enterococcusfaecalis) |
PF00199(Catalase)PF06628(Catalase-rel) | 5 | PHE A 188PHE A 313LEU A 113ALA A 90ALA A 58 | NoneHEM A 501 (-4.5A)NoneNoneNone | 1.09A | 4wnuD-1si8A:undetectable | 4wnuD-1si8A:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1svv | THREONINE ALDOLASE (Leishmaniamajor) |
PF01212(Beta_elim_lyase) | 5 | GLY A 270PHE A 266LEU A 260ALA A 214ALA A 185 | None | 1.26A | 4wnuD-1svvA:undetectable | 4wnuD-1svvA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t6p | PHENYLALANINEAMMONIA-LYASE (Rhodotorulatoruloides) |
PF00221(Lyase_aromatic) | 5 | GLU A 671LEU A 658ALA A 654ASP A 536SER A 652 | None | 1.22A | 4wnuD-1t6pA:3.1 | 4wnuD-1t6pA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tah | LIPASE (Burkholderiaglumae) |
no annotation | 5 | GLY B 232ALA B 300ASP B 287SER B 230ALA B 213 | NoneNone CA B 320 ( 3.4A)NoneNone | 1.20A | 4wnuD-1tahB:undetectable | 4wnuD-1tahB:22.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ted | PKS18 (Mycobacteriumtuberculosis) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 5 | GLY A 315LEU A 352ALA A 311SER A 337ALA A 334 | GLY A 315 ( 0.0A)LEU A 352 ( 0.6A)ALA A 311 ( 0.0A)SER A 337 ( 0.0A)ALA A 334 ( 0.0A) | 1.26A | 4wnuD-1tedA:undetectable | 4wnuD-1tedA:23.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tn3 | TETRANECTIN (Homo sapiens) |
PF00059(Lectin_C) | 5 | GLY A 105GLU A 107LEU A 172SER A 156ALA A 159 | None | 1.23A | 4wnuD-1tn3A:undetectable | 4wnuD-1tn3A:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ug3 | EUKARYOTIC PROTEINSYNTHESIS INITIATIONFACTOR 4G (Homo sapiens) |
PF02020(W2)PF02847(MA3) | 5 | GLY A1455LEU A1448ALA A1486SER A1490ALA A1491 | None | 0.88A | 4wnuD-1ug3A:undetectable | 4wnuD-1ug3A:21.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w8d | 2,4-DIENOYL-COAREDUCTASE,MITOCHONDRIALPRECURSOR (Homo sapiens) |
PF13561(adh_short_C2) | 5 | PHE A 57LEU A 82ALA A 282SER A 286ALA A 289 | GOL A1329 ( 4.2A)NoneNoneGOL A1329 (-4.3A)None | 1.31A | 4wnuD-1w8dA:undetectable | 4wnuD-1w8dA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wop | AMINOMETHYLTRANSFERASE (Thermotogamaritima) |
PF01571(GCV_T)PF08669(GCV_T_C) | 5 | PHE A 67GLY A 91GLU A 89LEU A 271ASP A 263 | None | 1.34A | 4wnuD-1wopA:undetectable | 4wnuD-1wopA:23.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2amc | PHENYLALANYL-TRNASYNTHETASE ALPHACHAIN (Thermusthermophilus) |
PF01409(tRNA-synt_2d) | 5 | GLY A 281PHE A 315LEU A 233ALA A 236ALA A 241 | None | 1.36A | 4wnuD-2amcA:undetectable | 4wnuD-2amcA:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c2g | THREONINE SYNTHASE (Arabidopsisthaliana) |
PF00291(PALP) | 5 | PHE A 303GLY A 295LEU A 333ALA A 368ALA A 302 | None | 1.35A | 4wnuD-2c2gA:undetectable | 4wnuD-2c2gA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cfc | 2-(R)-HYDROXYPROPYL-COM DEHYDROGENASE (Xanthobacterautotrophicus) |
PF13561(adh_short_C2) | 5 | GLY A 186LEU A 241ALA A 224ASP A 223ALA A 219 | KPC A1252 (-4.7A)NoneNoneNoneNone | 1.13A | 4wnuD-2cfcA:undetectable | 4wnuD-2cfcA:20.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cir | HEXOSE-6-PHOSPHATEMUTAROTASE (Saccharomycescerevisiae) |
PF01263(Aldose_epim) | 5 | GLY A 256LEU A 44ALA A 48ASP A 250ALA A 249 | None | 1.23A | 4wnuD-2cirA:undetectable | 4wnuD-2cirA:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d0v | METHANOLDEHYDROGENASE LARGESUBUNIT (Hyphomicrobiumdenitrificans) |
PF01011(PQQ)PF13360(PQQ_2) | 5 | GLY A 428GLN A 429PHE A 430SER A 100ALA A 97 | None | 1.36A | 4wnuD-2d0vA:undetectable | 4wnuD-2d0vA:21.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d3t | FATTY OXIDATIONCOMPLEX ALPHASUBUNIT (Pseudomonasfragi) |
PF00378(ECH_1)PF00725(3HCDH)PF02737(3HCDH_N) | 5 | GLY A 148GLU A 140LEU A 85ALA A 282ALA A 251 | None | 1.28A | 4wnuD-2d3tA:undetectable | 4wnuD-2d3tA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eid | GALACTOSE OXIDASE (Fusariumgraminearum) |
PF00754(F5_F8_type_C)PF01344(Kelch_1)PF09118(DUF1929) | 5 | PHE A 227GLY A 288GLN A 273ALA A 247SER A 291 | CU A 640 (-4.4A)NoneNoneNoneNone | 1.26A | 4wnuD-2eidA:undetectable | 4wnuD-2eidA:21.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2f9q | CYTOCHROME P450 2D6 (Homo sapiens) |
PF00067(p450) | 5 | PHE A 120GLY A 212GLN A 244ASP A 301ALA A 305 | HEM A 600 (-4.6A)NoneNoneNoneHEM A 600 (-3.6A) | 1.05A | 4wnuD-2f9qA:55.5 | 4wnuD-2f9qA:99.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2f9q | CYTOCHROME P450 2D6 (Homo sapiens) |
PF00067(p450) | 5 | PHE A 120GLY A 212GLU A 216GLN A 244ALA A 305 | HEM A 600 (-4.6A)NoneNoneNoneHEM A 600 (-3.6A) | 1.27A | 4wnuD-2f9qA:55.5 | 4wnuD-2f9qA:99.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2f9q | CYTOCHROME P450 2D6 (Homo sapiens) |
PF00067(p450) | 5 | PHE A 120GLY A 212GLU A 216LEU A 251ALA A 305 | HEM A 600 (-4.6A)NoneNoneNoneHEM A 600 (-3.6A) | 1.30A | 4wnuD-2f9qA:55.5 | 4wnuD-2f9qA:99.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2f9q | CYTOCHROME P450 2D6 (Homo sapiens) |
PF00067(p450) | 8 | PHE A 120GLY A 212PHE A 247LEU A 248ALA A 300ASP A 301SER A 304ALA A 305 | HEM A 600 (-4.6A)NoneNoneNoneNoneNoneNoneHEM A 600 (-3.6A) | 0.53A | 4wnuD-2f9qA:55.5 | 4wnuD-2f9qA:99.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fja | ADENYLYLSULFATEREDUCTASE, SUBUNIT A (Archaeoglobusfulgidus) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | PHE A 257GLY A 438LEU A 108ALA A 443ALA A 402 | NoneFAD A1000 (-3.5A)NoneNoneNone | 1.29A | 4wnuD-2fjaA:undetectable | 4wnuD-2fjaA:23.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fsr | ACETYLTRANSFERASE (Agrobacteriumfabrum) |
PF13302(Acetyltransf_3) | 5 | PHE A 119GLY A 94ALA A 113ASP A 116ALA A 118 | None | 1.24A | 4wnuD-2fsrA:undetectable | 4wnuD-2fsrA:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gdr | GLUTATHIONES-TRANSFERASE (Paraburkholderiaxenovorans) |
PF02798(GST_N)PF13410(GST_C_2) | 5 | GLY A 148GLU A 90ALA A 154SER A 152ALA A 83 | None | 1.10A | 4wnuD-2gdrA:undetectable | 4wnuD-2gdrA:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jbm | NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE (Homo sapiens) |
PF01729(QRPTase_C)PF02749(QRPTase_N) | 5 | GLY A 58GLN A 59PHE A 62ALA A 90ALA A 50 | None | 1.18A | 4wnuD-2jbmA:undetectable | 4wnuD-2jbmA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jh3 | RIBOSOMAL PROTEINS2-RELATED PROTEIN (Deinococcusradiodurans) |
PF01903(CbiX) | 5 | GLY A 52GLU A 50GLN A 55ALA A 449ALA A 451 | NoneNoneNoneNoneSF4 A 650 ( 4.5A) | 1.32A | 4wnuD-2jh3A:undetectable | 4wnuD-2jh3A:23.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oby | PUTATIVE QUINONEOXIDOREDUCTASE (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 62GLN A 95LEU A 330ALA A 36ALA A 120 | None | 1.08A | 4wnuD-2obyA:undetectable | 4wnuD-2obyA:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oix | XANTHOMONAS OUTERPROTEIN D (Xanthomonaseuvesicatoria) |
PF02902(Peptidase_C48) | 5 | PHE A 366GLU A 479LEU A 512ALA A 346ALA A 352 | None | 1.31A | 4wnuD-2oixA:undetectable | 4wnuD-2oixA:17.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p2c | CASPASE-2 (Homo sapiens) |
PF12796(Ank_2)PF13637(Ank_4) | 5 | GLY P 124LEU P 117ALA P 149SER P 153ALA P 162 | None | 1.29A | 4wnuD-2p2cP:undetectable | 4wnuD-2p2cP:14.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qv5 | UNCHARACTERIZEDPROTEIN ATU2773 (Agrobacteriumfabrum) |
PF04748(Polysacc_deac_2) | 5 | GLY A 315GLN A 325LEU A 304ALA A 328ASP A 329 | None | 1.29A | 4wnuD-2qv5A:undetectable | 4wnuD-2qv5A:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v7s | PROBABLE CONSERVEDLIPOPROTEIN LPPA (Mycobacteriumtuberculosis) |
PF16708(LppA) | 6 | GLY A 127PHE A 126ALA A 78ASP A 79SER A 82ALA A 83 | GOL A1208 (-3.3A)NoneNoneNoneNoneNone | 0.99A | 4wnuD-2v7sA:undetectable | 4wnuD-2v7sA:17.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vdc | GLUTAMATE SYNTHASE[NADPH] LARGE CHAIN (Azospirillumbrasilense) |
PF00310(GATase_2)PF01493(GXGXG)PF01645(Glu_synthase)PF04898(Glu_syn_central) | 5 | GLY A 494LEU A 658ALA A 620ASP A 608ALA A 617 | None | 1.06A | 4wnuD-2vdcA:undetectable | 4wnuD-2vdcA:15.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z8c | INSULIN RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | PHE A1276LEU A1267ALA A1114ASP A1118ALA A1121 | None | 1.27A | 4wnuD-2z8cA:undetectable | 4wnuD-2z8cA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a9x | SELENOCYSTEINE LYASE (Rattusnorvegicus) |
PF00266(Aminotran_5) | 5 | GLY A 75LEU A 70ALA A 297ASP A 298SER A 301 | None | 0.95A | 4wnuD-3a9xA:undetectable | 4wnuD-3a9xA:21.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bq3 | DEFECTIVE IN CULLINNEDDYLATION PROTEIN1 (Saccharomycescerevisiae) |
PF03556(Cullin_binding)PF14555(UBA_4) | 5 | GLU A 198GLN A 196PHE A 194ASP A 106ALA A 108 | None | 1.36A | 4wnuD-3bq3A:undetectable | 4wnuD-3bq3A:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c7t | ECDYSTEROID-PHOSPHATE PHOSPHATASE (Bombyx mori) |
PF00300(His_Phos_1) | 5 | GLY A 171GLU A 141PHE A 168LEU A 78ALA A 146 | None | 1.32A | 4wnuD-3c7tA:undetectable | 4wnuD-3c7tA:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3djl | PROTEIN AIDB (Escherichiacoli) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M) | 5 | PHE A 114GLY A 305LEU A 123ALA A 119ALA A 359 | None | 1.33A | 4wnuD-3djlA:undetectable | 4wnuD-3djlA:22.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f0w | NUMB-LIKE PROTEIN (Homo sapiens) |
PF00640(PID) | 5 | GLY A 86LEU A 175ALA A 156ASP A 150SER A 158 | None | 1.05A | 4wnuD-3f0wA:undetectable | 4wnuD-3f0wA:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ikm | DNA POLYMERASESUBUNIT GAMMA-1 (Homo sapiens) |
PF00476(DNA_pol_A) | 5 | PHE A 273GLY A 431PHE A 291ASP A 274ALA A 276 | None | 1.14A | 4wnuD-3ikmA:0.5 | 4wnuD-3ikmA:17.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j7a | 40S RIBOSOMALPROTEIN ES26 (Plasmodiumfalciparum) |
PF01283(Ribosomal_S26e) | 5 | PHE 3 83GLY 3 27LEU 3 21ALA 3 35ALA 3 78 | None | 1.08A | 4wnuD-3j7a3:undetectable | 4wnuD-3j7a3:12.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kiz | PHOSPHORIBOSYLFORMYLGLYCINAMIDINECYCLO-LIGASE (Cytophagahutchinsonii) |
PF02769(AIRS_C) | 5 | GLY A 241GLU A 242GLN A 324PHE A 217ALA A 256 | None | 1.23A | 4wnuD-3kizA:undetectable | 4wnuD-3kizA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l6c | SERINE RACEMASE (Rattusnorvegicus) |
PF00291(PALP) | 5 | GLY A 88GLN A 89ALA A 110ASP A 238SER A 84 | NoneNoneNoneNoneMLI A 341 (-2.7A) | 1.21A | 4wnuD-3l6cA:undetectable | 4wnuD-3l6cA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m9v | FAD-DEPENDENTOXIDOREDUCTASE (Actinomadurakijaniata) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 5 | GLY A 253ALA A 316ASP A 317SER A 320ALA A 321 | TYD A 901 (-3.3A)NoneNoneNoneNone | 0.85A | 4wnuD-3m9vA:undetectable | 4wnuD-3m9vA:23.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mq3 | PYRUVATEDEHYDROGENASEPHOSPHATASE 1 (Bos taurus) |
PF00481(PP2C) | 5 | PHE A 41GLY A 66LEU A 213ALA A 206ALA A 58 | None | 0.98A | 4wnuD-3mq3A:undetectable | 4wnuD-3mq3A:23.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n23 | SODIUM/POTASSIUM-TRANSPORTING ATPASESUBUNIT ALPHA-1 (Sus scrofa) |
PF00122(E1-E2_ATPase)PF00689(Cation_ATPase_C)PF00690(Cation_ATPase_N)PF13246(Cation_ATPase) | 5 | GLY A 950GLU A 954LEU A 815ASP A 926ALA A 925 | None | 1.26A | 4wnuD-3n23A:undetectable | 4wnuD-3n23A:19.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t44 | INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE (Mycobacteriumtuberculosis) |
PF00218(IGPS) | 5 | GLY A 53LEU A 229ALA A 261ASP A 257ALA A 256 | None | 1.31A | 4wnuD-3t44A:undetectable | 4wnuD-3t44A:24.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3umv | DEOXYRIBODIPYRIMIDINE PHOTO-LYASE (Oryza sativa) |
PF00875(DNA_photolyase) | 5 | GLY A 190PHE A 188LEU A 326SER A 178ALA A 179 | None | 1.19A | 4wnuD-3umvA:undetectable | 4wnuD-3umvA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aip | FE-REGULATED PROTEINB (Neisseriameningitidis) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 5 | GLY A 652LEU A 600ALA A 602SER A 639ALA A 638 | None | 1.33A | 4wnuD-4aipA:undetectable | 4wnuD-4aipA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dnv | AT5G63860/MGI19_6 (Arabidopsisthaliana) |
PF00415(RCC1) | 5 | GLY A 40GLN A 359LEU A 341ALA A 22ALA A 76 | None | 1.31A | 4wnuD-4dnvA:undetectable | 4wnuD-4dnvA:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dok | SIMILARITY TOCHALCONE-FLAVONONEISOMERASE (Arabidopsisthaliana) |
PF02431(Chalcone) | 5 | PHE A 75ALA A 201ASP A 202SER A 205ALA A 206 | None | 0.99A | 4wnuD-4dokA:undetectable | 4wnuD-4dokA:17.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e4g | METHYLMALONATE-SEMIALDEHYDEDEHYDROGENASE (Sinorhizobiummeliloti) |
PF00171(Aldedh) | 5 | PHE A 149GLY A 320GLU A 277ALA A 96ASP A 99 | None | 0.91A | 4wnuD-4e4gA:undetectable | 4wnuD-4e4gA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eku | PROTEIN-TYROSINEKINASE 2-BETA (Homo sapiens) |
PF00373(FERM_M) | 5 | GLY A 282GLU A 263LEU A 354ASP A 346ALA A 345 | None | 1.31A | 4wnuD-4ekuA:undetectable | 4wnuD-4ekuA:19.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fl4 | CELLULOSOMEANCHORING PROTEINCOHESIN REGION (Ruminiclostridiumthermocellum) |
PF00963(Cohesin) | 5 | GLY C 128GLU C 137ALA C 88SER C 40ALA C 39 | None | 1.27A | 4wnuD-4fl4C:undetectable | 4wnuD-4fl4C:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hiz | ENDOSIALIDASE (Enterobacteriaphage phi92) |
PF12217(End_beta_propel)PF12218(End_N_terminal)PF12219(End_tail_spike) | 5 | PHE A 154GLY A 181GLU A 178ALA A 157ALA A 176 | NoneEDO A 810 (-4.1A)NoneNoneNone | 1.21A | 4wnuD-4hizA:undetectable | 4wnuD-4hizA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jcs | ENOYL-COAHYDRATASE/ISOMERASE (Cupriavidusmetallidurans) |
PF00378(ECH_1) | 5 | GLY A 112PHE A 130ALA A 128ASP A 105ALA A 103 | None | 1.18A | 4wnuD-4jcsA:undetectable | 4wnuD-4jcsA:24.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kpp | PUTATIVEUNCHARACTERIZEDPROTEIN (Archaeoglobusfulgidus) |
PF01699(Na_Ca_ex) | 5 | GLY A 217PHE A 213LEU A 212ALA A 53ALA A 74 | None | 1.27A | 4wnuD-4kppA:undetectable | 4wnuD-4kppA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nen | INTEGRIN ALPHA-X (Homo sapiens) |
PF00092(VWA)PF01839(FG-GAP)PF08441(Integrin_alpha2) | 5 | PHE A 361GLY A 90LEU A 87ALA A 339ALA A 350 | None | 1.29A | 4wnuD-4nenA:undetectable | 4wnuD-4nenA:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ony | EXTRACELLULARSOLUTE-BINDINGPROTEIN FAMILY 5 (Brucellamelitensis) |
PF00496(SBP_bac_5) | 5 | GLU A 374ALA A 538ASP A 539SER A 542ALA A 543 | None | 1.30A | 4wnuD-4onyA:undetectable | 4wnuD-4onyA:22.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4otd | SERINE/THREONINE-PROTEIN KINASE N1 (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 5 | GLY A 808LEU A 815ALA A 723SER A 727ALA A 728 | None | 0.64A | 4wnuD-4otdA:undetectable | 4wnuD-4otdA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4psd | CARBOHYDRATEESTERASE FAMILY 5 (Trichodermareesei) |
PF01083(Cutinase) | 5 | GLY A 162LEU A 209ALA A 239ASP A 235ALA A 233 | None | 1.28A | 4wnuD-4psdA:undetectable | 4wnuD-4psdA:18.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qyr | AT-LESS POLYKETIDESYNTHASE (Streptomycesplatensis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | GLY A3045PHE A3061LEU A3058ALA A3007ALA A2997 | None | 1.18A | 4wnuD-4qyrA:undetectable | 4wnuD-4qyrA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r72 | ABC-TYPE FE3+TRANSPORT SYSTEM,PERIPLASMICCOMPONENT (Actinobacilluspleuropneumoniae) |
PF13343(SBP_bac_6) | 5 | GLY A 225GLU A 224LEU A 107ALA A 154ALA A 167 | None | 1.29A | 4wnuD-4r72A:undetectable | 4wnuD-4r72A:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u3t | PENICILLIN-BINDINGPROTEIN 2 (Neisseriagonorrhoeae) |
PF00905(Transpeptidase) | 5 | PHE A 462GLU A 385ALA A 323ASP A 322ALA A 318 | None | 1.35A | 4wnuD-4u3tA:undetectable | 4wnuD-4u3tA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ahk | ACETOLACTATESYNTHASE II, LARGESUBUNIT (Pseudomonasprotegens) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | PHE A 424GLY A 160ALA A 52SER A 56ALA A 57 | None | 1.12A | 4wnuD-5ahkA:undetectable | 4wnuD-5ahkA:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aw4 | NA, K-ATPASE ALPHASUBUNIT (Squalusacanthias) |
PF00122(E1-E2_ATPase)PF00689(Cation_ATPase_C)PF00690(Cation_ATPase_N)PF13246(Cation_ATPase) | 5 | GLY A 957GLU A 961LEU A 822ASP A 933ALA A 932 | None | 1.32A | 4wnuD-5aw4A:undetectable | 4wnuD-5aw4A:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bp1 | MYCOCEROSIC ACIDSYNTHASE (Mycolicibacteriumsmegmatis) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | LEU A 508ALA A 849ASP A 850SER A 853ALA A 854 | None | 1.17A | 4wnuD-5bp1A:undetectable | 4wnuD-5bp1A:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e6s | INTEGRIN ALPHA-L (Homo sapiens) |
PF00092(VWA)PF01839(FG-GAP)PF08441(Integrin_alpha2) | 5 | GLY A 81LEU A 25ALA A 75ASP A 332ALA A 338 | None | 1.35A | 4wnuD-5e6sA:undetectable | 4wnuD-5e6sA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eo6 | COPROPORPHYRINOGENOXIDASE (Acinetobacterbaumannii) |
PF01218(Coprogen_oxidas) | 5 | PHE A 164GLY A 136PHE A 138ALA A 157ALA A 213 | None | 1.33A | 4wnuD-5eo6A:undetectable | 4wnuD-5eo6A:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eoe | BETA-LACTAMASE (Pseudomonasaeruginosa) |
PF13354(Beta-lactamase2) | 5 | GLY A 108LEU A 94ALA A 126ASP A 124ALA A 115 | None | 1.26A | 4wnuD-5eoeA:undetectable | 4wnuD-5eoeA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eov | 16S/23S RRNA(CYTIDINE-2'-O)-METHYLTRANSFERASE TLYA (Mycobacteriumtuberculosis) |
PF01728(FtsJ) | 5 | GLY A 114LEU A 155ALA A 89ASP A 88ALA A 110 | None | 1.14A | 4wnuD-5eovA:undetectable | 4wnuD-5eovA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5guj | DNA PRIMASE (Bacillussubtilis) |
PF08275(Toprim_N)PF10410(DnaB_bind)PF13155(Toprim_2) | 5 | GLY A 149ALA A 271ASP A 272SER A 275ALA A 276 | None | 0.93A | 4wnuD-5gujA:undetectable | 4wnuD-5gujA:20.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h5j | FERREDOXIN--NADPREDUCTASE (Zea mays) |
PF00175(NAD_binding_1) | 5 | GLU A 162PHE A 189LEU A 185ALA A 202ALA A 167 | None | 1.28A | 4wnuD-5h5jA:undetectable | 4wnuD-5h5jA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hb4 | NUP192,NUCLEOPORINNUP192 (Chaetomiumthermophilum) |
PF11894(Nup192) | 5 | GLY B 395GLN B 398ALA B 381ASP B 382ALA B 385 | None | 1.21A | 4wnuD-5hb4B:undetectable | 4wnuD-5hb4B:15.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ht7 | UNCHARACTERIZEDPROTEIN (Methanothrixthermoacetophila) |
PF00030(Crystall) | 5 | GLU A 49GLN A 53PHE A 52ALA A 22ASP A 23 | None | 1.14A | 4wnuD-5ht7A:undetectable | 4wnuD-5ht7A:9.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ht7 | UNCHARACTERIZEDPROTEIN (Methanothrixthermoacetophila) |
PF00030(Crystall) | 5 | GLU A 49GLN A 53PHE A 52ALA A 22SER A 78 | None | 1.33A | 4wnuD-5ht7A:undetectable | 4wnuD-5ht7A:9.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jhe | PEPTIDYL-PROLYLCIS-TRANS ISOMERASECYP7 (Saccharomycescerevisiae) |
PF00160(Pro_isomerase)PF00515(TPR_1) | 5 | GLY A 247GLU A 245LEU A 298SER A 266ALA A 240 | None | 1.26A | 4wnuD-5jheA:undetectable | 4wnuD-5jheA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lj6 | MACROLIDE EXPORTATP-BINDING/PERMEASEPROTEIN MACB (Aggregatibacteractinomycetemcomitans) |
no annotation | 5 | GLY A 132GLU A 129LEU A 144ALA A 102ALA A 124 | None | 1.24A | 4wnuD-5lj6A:0.0 | 4wnuD-5lj6A:21.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ljo | OUTER MEMBRANEPROTEIN ASSEMBLYFACTOR BAMA (Escherichiacoli) |
PF01103(Bac_surface_Ag)PF07244(POTRA) | 5 | GLN A 803PHE A 663ASP A 740SER A 769ALA A 770 | None | 1.23A | 4wnuD-5ljoA:undetectable | 4wnuD-5ljoA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mjv | CAPSID SUBUNIT VP0CAPSID SUBUNIT VP1CAPSID SUBUNIT VP3 (Parechovirus A) |
PF00073(Rhv)no annotation | 5 | GLY B 182GLU C 216ASP A 38SER A 35ALA A 36 | None | 1.32A | 4wnuD-5mjvB:undetectable | 4wnuD-5mjvB:19.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v2i | GLYCOSYLASPARAGINASE (Elizabethkingiameningoseptica) |
PF01112(Asparaginase_2) | 5 | GLY A 162GLU A 72LEU A 25ALA A 157ALA A 199 | None | 1.22A | 4wnuD-5v2iA:undetectable | 4wnuD-5v2iA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wbl | REGULATORY-ASSOCIATED PROTEIN OF TOR 1 (Arabidopsisthaliana) |
no annotation | 5 | PHE A 440PHE A 311LEU A 308ALA A 417ALA A 412 | None | 1.31A | 4wnuD-5wblA:undetectable | 4wnuD-5wblA:10.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xao | UNCHARACTERIZEDPROTEIN (Parastagonosporanodorum) |
PF01266(DAO) | 5 | LEU A 63ALA A 351ASP A 347SER A 413ALA A 410 | None | 1.35A | 4wnuD-5xaoA:undetectable | 4wnuD-5xaoA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xbk | IMPORTIN-4 (Homo sapiens) |
no annotation | 5 | PHE D 921GLY D 930GLU D 928LEU D 941ALA D 883 | None | 1.13A | 4wnuD-5xbkD:undetectable | 4wnuD-5xbkD:10.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xmg | UNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
no annotation | 5 | GLY A 73LEU A 255ALA A 257ASP A 261ALA A 235 | None | 0.92A | 4wnuD-5xmgA:undetectable | 4wnuD-5xmgA:12.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ya1 | AUTOINDUCER-2 KINASE (Escherichiacoli) |
no annotation | 5 | GLY A 103LEU A 213ALA A 215SER A 219ALA A 184 | None | 1.35A | 4wnuD-5ya1A:undetectable | 4wnuD-5ya1A:9.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yh0 | DRFAM20C1 (Danio rerio) |
no annotation | 5 | PHE A 299GLY A 431PHE A 459ALA A 290ASP A 294 | None | 1.24A | 4wnuD-5yh0A:undetectable | 4wnuD-5yh0A:10.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yh3 | EXTRACELLULARSERINE/THREONINEPROTEIN KINASEFAM20C (Homo sapiens) |
no annotation | 5 | PHE C 323GLY C 455PHE C 483ALA C 314ASP C 318 | None | 1.26A | 4wnuD-5yh3C:undetectable | 4wnuD-5yh3C:13.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zw4 | PUTATIVEO-METHYLTRANSFERASEYRRM (Bacillussubtilis) |
no annotation | 5 | GLY A 112GLU A 116PHE A 110ALA A 120ASP A 119 | None | 1.27A | 4wnuD-5zw4A:undetectable | 4wnuD-5zw4A:11.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cbo | C-6'AMINOTRANSFERASE (Micromonosporaechinospora) |
no annotation | 5 | GLY A 305PHE A 301ASP A 366SER A 369ALA A 370 | None | 1.19A | 4wnuD-6cboA:undetectable | 4wnuD-6cboA:10.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cip | PYRUVATE-FERREDOXINOXIDOREDUCTASE (Moorellathermoacetica) |
no annotation | 5 | GLY A 87GLN A 86ALA A 126ASP A 124ALA A 111 | HTL A1204 ( 4.6A)NoneNoneNoneNone | 1.36A | 4wnuD-6cipA:undetectable | 4wnuD-6cipA:12.63 |