SIMILAR PATTERNS OF AMINO ACIDS FOR 4WNU_A_QDNA602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Plasmodium
falciparum) 		PF00274
(Glycolytic) 		5 LEU A  68
GLY A 308
GLU A  40
GLN A 312
ALA A  81
 None
 1.09A 4wnuA-1a5cA:
0.0		 4wnuA-1a5cA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgm ADENOSINE KINASE

(Toxoplasma
gondii) 		PF00294
(PfkB) 		5 LEU A 195
PHE A  16
LEU A 213
ALA A 182
PHE A 148
 None
 1.13A 4wnuA-1dgmA:
0.0		 4wnuA-1dgmA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgr CANAVALIN

(Canavalia
ensiformis) 		PF00190
(Cupin_1) 		5 LEU A  69
GLU A 173
LEU A  89
ALA A 163
SER A 106
 None
 1.06A 4wnuA-1dgrA:
undetectable		 4wnuA-1dgrA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 PHE A 281
GLY A 175
LEU A 176
LEU A 225
ALA A 312
 None
 1.15A 4wnuA-1ethA:
0.0		 4wnuA-1ethA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gg4 UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMYL-2,
6-DIAMINOPIMELATE-D-
ALANYL-D-ALANYL
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 LEU A  75
GLY A  60
PHE A  40
LEU A  65
ALA A  54
 None
 1.18A 4wnuA-1gg4A:
0.0		 4wnuA-1gg4A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		5 LEU A 451
LEU A 443
GLN A 447
LEU A 367
ALA A 228
 None
 1.18A 4wnuA-1gk2A:
0.4		 4wnuA-1gk2A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hv8 PUTATIVE
ATP-DEPENDENT RNA
HELICASE MJ0669

(Methanocaldococcus
jannaschii) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A  41
PHE A  61
LEU A  97
PHE A   8
LEU A  11
 None
 0.96A 4wnuA-1hv8A:
0.0		 4wnuA-1hv8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k72 ENDOGLUCANASE 9G

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		5 LEU A 305
LEU A 345
GLN A 348
LEU A 314
ALA A 352
 None
 1.21A 4wnuA-1k72A:
0.1		 4wnuA-1k72A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LEU A 234
LEU A 109
LEU A 100
ALA A 190
PHE A 221
 None
 1.14A 4wnuA-1mu2A:
undetectable		 4wnuA-1mu2A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nf2 PHOSPHATASE

(Thermotoga
maritima) 		PF08282
(Hydrolase_3) 		5 LEU A 195
PHE A   7
GLY A 226
LEU A 227
PHE A 222
 None
 1.00A 4wnuA-1nf2A:
undetectable		 4wnuA-1nf2A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 GLY A 602
LEU A 603
GLU A 606
PHE A 597
ALA A 571
 None
 1.08A 4wnuA-1ogyA:
undetectable		 4wnuA-1ogyA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE

(Saccharomyces
cerevisiae) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY A 374
LEU A 373
GLN A 275
ALA A 208
SER A 211
 None
 1.20A 4wnuA-1pxtA:
undetectable		 4wnuA-1pxtA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rp1 PANCREATIC LIPASE
RELATED PROTEIN 1

(Canis lupus) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 PHE A 280
GLY A 174
LEU A 175
LEU A 224
ALA A 311
 None
 1.18A 4wnuA-1rp1A:
undetectable		 4wnuA-1rp1A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uf3 HYPOTHETICAL PROTEIN
TT1561

(Thermus
thermophilus) 		PF14582
(Metallophos_3) 		5 GLY A  40
LEU A  42
LEU A 185
ALA A  37
PHE A  55
 None
 1.08A 4wnuA-1uf3A:
undetectable		 4wnuA-1uf3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3o ACYL CARRIER PROTEIN

(Thermus
thermophilus) 		PF00550
(PP-binding) 		5 GLY A  48
LEU A  49
GLU A  52
ALA A  15
PHE A  53
 None
 0.89A 4wnuA-1x3oA:
undetectable		 4wnuA-1x3oA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii) 		PF09043
(Lys-AminoMut_A) 		5 LEU A 301
GLY A 337
LEU A 336
SER A 316
PHE A 364
 None
 1.16A 4wnuA-1xrsA:
undetectable		 4wnuA-1xrsA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cav PROTEIN (CANAVALIN)

(Canavalia
ensiformis) 		PF00190
(Cupin_1) 		5 LEU A  69
GLU A 173
LEU A  89
ALA A 163
SER A 106
 None
 1.02A 4wnuA-2cavA:
undetectable		 4wnuA-2cavA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cje DUTPASE

(Leishmania
major) 		PF08761
(dUTPase_2) 		5 LEU A  52
PHE A 129
LEU A 148
LEU A  77
ALA A 164
 None
 0.95A 4wnuA-2cjeA:
undetectable		 4wnuA-2cjeA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t 3-KETOACYL-COA
THIOLASE

(Pseudomonas
fragi) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY C 346
LEU C 345
GLN C 244
ALA C 173
SER C 176
 None
 1.11A 4wnuA-2d3tC:
undetectable		 4wnuA-2d3tC:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzd PYRUVATE CARBOXYLASE

(Geobacillus
thermodenitrificans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 LEU A 433
GLU A 434
PHE A 442
LEU A 443
ALA A 411
 None
 0.93A 4wnuA-2dzdA:
undetectable		 4wnuA-2dzdA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eui PROBABLE
ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		5 LEU A  38
LEU A  66
GLN A  65
LEU A  42
ALA A   6
 None
 1.09A 4wnuA-2euiA:
undetectable		 4wnuA-2euiA:
15.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 110
GLY A 212
LEU A 213
PHE A 247
LEU A 248
 None
 0.98A 4wnuA-2f9qA:
55.2		 4wnuA-2f9qA:
99.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9q CYTOCHROME P450 2D6

(Homo sapiens) 		PF00067
(p450) 		7 LEU A 110
PHE A 120
GLY A 212
PHE A 247
LEU A 248
ALA A 300
SER A 304
 None
HEM  A 600 (-4.6A)
None
None
None
None
None
 0.60A 4wnuA-2f9qA:
55.2		 4wnuA-2f9qA:
99.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis) 		PF01274
(Malate_synthase) 		5 LEU A 714
PHE A 721
GLY A 607
LEU A 698
ALA A 694
 None
 1.10A 4wnuA-2gq3A:
undetectable		 4wnuA-2gq3A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		5 LEU A 644
GLU A 645
PHE A 516
ALA A 650
PHE A 448
 None
 1.13A 4wnuA-2h4tA:
undetectable		 4wnuA-2h4tA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 LEU A 387
LEU A 673
GLN A 692
LEU A 702
ALA A 705
 None
 1.17A 4wnuA-2hnhA:
undetectable		 4wnuA-2hnhA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jii SERINE/THREONINE-PRO
TEIN KINASE VRK3
MOLECULE: VACCINIA
RELATED KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 290
PHE A 296
GLY A 326
ALA A 240
PHE A 217
 None
 1.17A 4wnuA-2jiiA:
undetectable		 4wnuA-2jiiA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2knh PROTEIN CBFA2T1

(Homo sapiens) 		PF07531
(TAFH) 		5 LEU A 337
GLY A 302
LEU A 301
PHE A 313
LEU A 333
 None
 1.15A 4wnuA-2knhA:
undetectable		 4wnuA-2knhA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mas INOSINE-URIDINE
NUCLEOSIDE
N-RIBOHYDROLASE

(Crithidia
fasciculata) 		PF01156
(IU_nuc_hydro) 		5 GLY A 302
LEU A 305
PHE A 297
LEU A 295
ALA A 197
 None
 0.96A 4wnuA-2masA:
undetectable		 4wnuA-2masA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pkg SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
65 KDA REGULATORY
SUBUNIT A ALPHA
ISOFORM

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		5 LEU A 544
PHE A 538
GLY A 530
LEU A 564
ALA A 579
 None
 1.22A 4wnuA-2pkgA:
undetectable		 4wnuA-2pkgA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl2 HYPOTHETICAL
CONSERVED PROTEIN
TTC0263

(Thermus
thermophilus) 		PF13429
(TPR_15)
PF14559
(TPR_19) 		5 LEU A 154
LEU A  74
LEU A 124
ALA A 127
SER A 104
 None
 1.11A 4wnuA-2pl2A:
undetectable		 4wnuA-2pl2A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q30 UNCHARACTERIZED
PROTEIN

(Desulfovibrio
alaskensis) 		PF07883
(Cupin_2) 		5 GLY A  92
LEU A  45
GLU A  44
PHE A  67
ALA A  77
 None
 1.22A 4wnuA-2q30A:
undetectable		 4wnuA-2q30A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		5 LEU A 714
GLY A 834
LEU A 697
ALA A 702
PHE A 898
 None
 1.10A 4wnuA-2r8qA:
undetectable		 4wnuA-2r8qA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5o ALPHA-L-ARABINOFURAN
OSIDASE

(Fusarium
graminearum) 		no annotation 5 LEU A 130
GLY A  97
LEU A  98
SER A 124
PHE A  71
 None
 1.06A 4wnuA-2w5oA:
undetectable		 4wnuA-2w5oA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yky BETA-TRANSAMINASE

(Mesorhizobium
sp. LUK) 		PF00202
(Aminotran_3) 		5 LEU A 239
GLY A 195
LEU A 194
LEU A 207
PHE A 179
 None
 1.11A 4wnuA-2ykyA:
undetectable		 4wnuA-2ykyA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zkt 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Pyrococcus
horikoshii) 		PF01676
(Metalloenzyme)
PF10143
(PhosphMutase) 		5 LEU A 331
PHE A 378
LEU A   9
LEU A 336
ALA A 366
 None
 1.00A 4wnuA-2zktA:
undetectable		 4wnuA-2zktA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a71 EXO-ARABINANASE

(Penicillium
chrysogenum) 		no annotation 5 LEU A 134
GLY A 101
LEU A 102
SER A 128
PHE A  75
 None
 1.04A 4wnuA-3a71A:
undetectable		 4wnuA-3a71A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahr ERO1-LIKE PROTEIN
ALPHA

(Homo sapiens) 		PF04137
(ERO1) 		5 LEU A 254
GLU A 186
GLN A 404
LEU A 307
SER A 453
 None
 1.21A 4wnuA-3ahrA:
1.2		 4wnuA-3ahrA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb6 UNCHARACTERIZED
PROTEIN YEAR

(Escherichia
coli) 		PF09313
(DUF1971) 		5 GLY A  54
LEU A  53
GLN A  65
PHE A  77
ALA A  75
 None
 1.23A 4wnuA-3bb6A:
undetectable		 4wnuA-3bb6A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 LEU A 179
PHE A 169
GLY A 114
LEU A 113
ALA A 200
 None
 1.08A 4wnuA-3d1jA:
undetectable		 4wnuA-3d1jA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmc NTF2-LIKE PROTEIN

(Trichormus
variabilis) 		PF12680
(SnoaL_2) 		5 PHE A  44
GLY A  23
LEU A  24
PHE A  32
LEU A  33
 None
 1.09A 4wnuA-3dmcA:
undetectable		 4wnuA-3dmcA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1r FIBROBLAST GROWTH
FACTOR 20

(Homo sapiens) 		PF00167
(FGF) 		5 LEU A 203
GLY A 112
LEU A 117
PHE A  95
LEU A  94
 None
 1.16A 4wnuA-3f1rA:
undetectable		 4wnuA-3f1rA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fkf THIOL-DISULFIDE
OXIDOREDUCTASE

(Bacteroides
fragilis) 		PF13905
(Thioredoxin_8) 		5 LEU A 112
GLY A  69
LEU A  68
LEU A  72
ALA A 104
 None
 1.21A 4wnuA-3fkfA:
undetectable		 4wnuA-3fkfA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnq GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE, TYPE
I

(Burkholderia
pseudomallei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		5 LEU A  85
GLY A   8
GLU A  97
LEU A  77
ALA A  33
 None
 1.22A 4wnuA-3gnqA:
undetectable		 4wnuA-3gnqA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j09 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00403
(HMA)
PF00702
(Hydrolase) 		5 LEU A 372
PHE A 118
GLY A 109
LEU A 111
PHE A 170
 None
 1.12A 4wnuA-3j09A:
undetectable		 4wnuA-3j09A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld1 REPLICASE
POLYPROTEIN 1A

(Avian
coronavirus) 		no annotation 5 GLY A 347
GLU A 287
PHE A 349
LEU A 351
ALA A 292
 None
 1.21A 4wnuA-3ld1A:
undetectable		 4wnuA-3ld1A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lu2 LMO2462 PROTEIN

(Listeria
monocytogenes) 		PF01244
(Peptidase_M19) 		5 LEU A 104
GLY A 111
GLU A 108
LEU A 120
ALA A  63
 None
 1.03A 4wnuA-3lu2A:
undetectable		 4wnuA-3lu2A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2r METHYL-COENZYME M
REDUCTASE I SUBUNIT
BETA

(Methanothermobacter
marburgensis) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 LEU B 310
GLY B 350
LEU B 331
ALA B 389
SER B 385
 None
 1.10A 4wnuA-3m2rB:
undetectable		 4wnuA-3m2rB:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3maj DNA PROCESSING CHAIN
A

(Rhodopseudomonas
palustris) 		PF02481
(DNA_processg_A) 		5 LEU A 101
PHE A  37
GLY A 112
LEU A  89
LEU A 230
 None
 1.14A 4wnuA-3majA:
undetectable		 4wnuA-3majA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdu N-FORMIMINO-L-GLUTAM
ATE IMINOHYDROLASE

(Pseudomonas
aeruginosa) 		PF01979
(Amidohydro_1) 		5 LEU A 406
GLY A  14
LEU A  11
LEU A 405
ALA A  47
 None
 1.07A 4wnuA-3mduA:
undetectable		 4wnuA-3mduA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7j OHCU DECARBOXYLASE

(Klebsiella
pneumoniae) 		PF09349
(OHCU_decarbox) 		5 LEU A  64
GLY A 114
GLU A 110
LEU A  60
ALA A 148
 None
 1.14A 4wnuA-3o7jA:
undetectable		 4wnuA-3o7jA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		5 LEU A 173
GLU A 160
LEU A 168
ALA A  93
SER A  96
 None
 0.98A 4wnuA-3qqvA:
undetectable		 4wnuA-3qqvA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L

(Escherichia
coli) 		no annotation 5 LEU L 461
GLY L 383
LEU L 386
PHE L 379
ALA L 348
 None
 1.11A 4wnuA-3rkoL:
2.8		 4wnuA-3rkoL:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmt 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE 1

(Bacillus
halodurans) 		PF00275
(EPSP_synthase) 		5 LEU A 296
PHE A 242
GLY A 268
LEU A 316
LEU A 280
 None
 1.03A 4wnuA-3rmtA:
undetectable		 4wnuA-3rmtA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqi GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Coxiella
burnetii) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 GLY A 263
LEU A 265
PHE A 294
LEU A 298
ALA A 311
 None
 0.88A 4wnuA-3tqiA:
undetectable		 4wnuA-3tqiA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE

(Pyrococcus
horikoshii) 		no annotation 5 LEU A 214
PHE A   8
GLY A  85
LEU A  12
LEU A 125
 None
 1.20A 4wnuA-3u4gA:
undetectable		 4wnuA-3u4gA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 LEU A 514
GLY A 487
LEU A 529
LEU A 513
ALA A 418
 None
 0.88A 4wnuA-3uszA:
undetectable		 4wnuA-3uszA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Homo sapiens) 		PF00079
(Serpin) 		5 LEU A  82
GLY A  38
LEU A  78
ALA A   9
SER A  13
 None
 1.14A 4wnuA-3ut3A:
undetectable		 4wnuA-3ut3A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT

(Homo sapiens) 		PF00149
(Metallophos)
PF16891
(STPPase_N) 		5 LEU A  90
LEU A 241
LEU A  88
ALA A 163
PHE A 235
 None
 1.12A 4wnuA-3v4yA:
undetectable		 4wnuA-3v4yA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrh UBIQUITIN
THIOESTERASE ZRANB1

(Homo sapiens) 		PF02338
(OTU) 		5 LEU A 375
LEU A 363
ALA A 465
SER A 469
PHE A 370
 None
 1.16A 4wnuA-3zrhA:
undetectable		 4wnuA-3zrhA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnk L-AMINO ACID OXIDASE

(Streptococcus
cristatus) 		PF03486
(HI0933_like) 		5 PHE A 333
GLY A 325
LEU A 198
ALA A 192
PHE A 232
 FAD  A1392 (-4.2A)
None
None
None
None
 1.05A 4wnuA-4cnkA:
undetectable		 4wnuA-4cnkA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Toxoplasma
gondii) 		PF00274
(Glycolytic) 		5 LEU A 133
GLY A 373
GLU A 105
GLN A 377
ALA A 146
 None
SO4  A1418 (-3.4A)
None
None
None
 1.08A 4wnuA-4d2jA:
undetectable		 4wnuA-4d2jA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae) 		PF01274
(Malate_synthase) 		5 LEU A 719
PHE A 726
GLY A 612
LEU A 703
ALA A 699
 None
 1.14A 4wnuA-4ex4A:
undetectable		 4wnuA-4ex4A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3e CASA

(Thermus
thermophilus) 		PF09481
(CRISPR_Cse1) 		5 GLY A 485
LEU A 482
GLU A 486
LEU A 388
ALA A 464
 None
 1.14A 4wnuA-4f3eA:
undetectable		 4wnuA-4f3eA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		5 LEU A  19
PHE A  25
GLY A  29
LEU A  33
ALA A  45
 None
 1.19A 4wnuA-4g2rA:
undetectable		 4wnuA-4g2rA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gni PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		5 LEU A 169
GLY A  21
PHE A  79
LEU A  83
ALA A 131
 None
ATP  A 502 (-3.3A)
None
None
None
 1.10A 4wnuA-4gniA:
undetectable		 4wnuA-4gniA:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hrw CYTIDINE AND
DEOXYCYTIDYLATE
DEAMINASE
ZINC-BINDING REGION

(Nitrosomonas
europaea) 		PF00383
(dCMP_cyt_deam_1) 		5 GLY A  31
LEU A  34
GLU A  35
LEU A  60
ALA A  63
 None
 1.17A 4wnuA-4hrwA:
undetectable		 4wnuA-4hrwA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsp HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF11736
(DUF3299) 		5 LEU A  33
GLY A  83
LEU A  28
ALA A  79
PHE A  99
 None
 1.20A 4wnuA-4hspA:
undetectable		 4wnuA-4hspA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il6 PHOTOSYSTEM Q(B)
PROTEIN

(Thermosynechococcus
vulcanus) 		PF00124
(Photo_RC) 		5 GLY A 171
PHE A 158
LEU A 120
ALA A 154
PHE A 186
 None
PHO  A1007 ( 4.9A)
LMG  A1012 ( 4.1A)
CLA  A1005 ( 4.3A)
CLA  A1005 (-4.0A)
 1.17A 4wnuA-4il6A:
undetectable		 4wnuA-4il6A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m46 LUCIFERASE

(Lampyris
turkestanicus) 		PF00501
(AMP-binding) 		5 GLY A 363
PHE A 432
LEU A 390
ALA A 371
PHE A 227
 None
 1.22A 4wnuA-4m46A:
undetectable		 4wnuA-4m46A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mes THIAMINE TRANSPORTER
THIT

(Lactococcus
lactis) 		PF09515
(Thia_YuaJ) 		5 PHE A 124
GLY A  56
LEU A  57
LEU A  45
ALA A 117
 None
None
PEG  A 212 ( 4.5A)
None
None
 1.13A 4wnuA-4mesA:
undetectable		 4wnuA-4mesA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nv2 VKORC1/THIOREDOXIN
DOMAIN PROTEIN

(Synechococcus
sp.
JA-2-3B'a(2-13)) 		PF07884
(VKOR) 		5 GLY A  76
LEU A  77
LEU A 143
ALA A  27
SER A  31
 U10  A 501 (-3.6A)
None
None
None
None
 1.12A 4wnuA-4nv2A:
undetectable		 4wnuA-4nv2A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		5 LEU A 453
PHE A 320
GLY A 335
ALA A 350
SER A 510
 None
 1.02A 4wnuA-4oe5A:
1.1		 4wnuA-4oe5A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pc9 C4-DICARBOXYLATE
TRANSPORT SYSTEM,
SUBSTRATE-BINDING
PROTEIN, PUTATIVE

(Roseobacter
denitrificans) 		PF03480
(DctP) 		5 LEU A 115
GLY A 271
LEU A 272
GLU A 269
SER A 276
 None
 1.14A 4wnuA-4pc9A:
undetectable		 4wnuA-4pc9A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmz XYLANASE

(Xanthomonas
citri) 		PF00331
(Glyco_hydro_10) 		5 LEU A 133
GLU A 134
GLN A  90
PHE A  89
LEU A  52
 None
 1.18A 4wnuA-4pmzA:
undetectable		 4wnuA-4pmzA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdi UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE

(Acinetobacter
baumannii) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 LEU A 385
PHE A 403
GLY A 449
ALA A 399
PHE A 452
 None
 1.17A 4wnuA-4qdiA:
undetectable		 4wnuA-4qdiA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7z CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus) 		PF00493
(MCM) 		5 LEU A 821
GLY A 328
LEU A 835
LEU A 761
ALA A 800
 None
 1.14A 4wnuA-4r7zA:
undetectable		 4wnuA-4r7zA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9z UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF13622
(4HBT_3) 		5 LEU A  12
GLY A  37
LEU A  35
LEU A 191
SER A 152
 None
 1.12A 4wnuA-4r9zA:
undetectable		 4wnuA-4r9zA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcd BETA-SECRETASE 1

(Homo sapiens) 		PF00026
(Asp) 		5 LEU A 133
GLY A 120
LEU A 121
PHE A  38
ALA A  97
 None
 1.21A 4wnuA-4rcdA:
undetectable		 4wnuA-4rcdA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4us4 TRANSPORTER

(Bacillus
halodurans) 		PF00209
(SNF) 		5 PHE A 314
GLY A 184
LEU A 187
LEU A 179
ALA A 319
 None
 1.08A 4wnuA-4us4A:
0.4		 4wnuA-4us4A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpr ALPHA-GLUCOSIDASE

(Pseudopedobacter
saltans) 		PF01055
(Glyco_hydro_31)
PF17137
(DUF5110) 		5 LEU A  89
PHE A 147
GLY A 198
LEU A  80
ALA A  40
 None
 1.21A 4wnuA-4xprA:
undetectable		 4wnuA-4xprA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlq EXPORTIN-4

(Mus musculus) 		no annotation 5 LEU B 327
PHE B 278
GLY B 343
LEU B 351
ALA B 303
 None
 1.14A 4wnuA-5dlqB:
2.8		 4wnuA-5dlqB:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fi5 TETRAHYDROALSTONINE
SYNTHASE

(Catharanthus
roseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 350
LEU A 353
LEU A  46
ALA A 138
SER A 135
 None
 1.13A 4wnuA-5fi5A:
undetectable		 4wnuA-5fi5A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2

(Arabidopsis
thaliana) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		5 LEU A 370
GLY A 476
PHE A 378
LEU A 403
ALA A 406
 None
 1.21A 4wnuA-5gxuA:
undetectable		 4wnuA-5gxuA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyz LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding) 		5 GLY A 363
PHE A 432
LEU A 390
ALA A 371
PHE A 227
 None
 1.18A 4wnuA-5gyzA:
undetectable		 4wnuA-5gyzA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it0 PHOSPHOSERINE
PHOSPHATASE

(Mycobacterium
avium) 		PF12710
(HAD)
PF13740
(ACT_6) 		5 LEU A 374
GLY A 139
LEU A 140
LEU A 385
ALA A 170
 None
 1.19A 4wnuA-5it0A:
undetectable		 4wnuA-5it0A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it1 PUTATIVE CYTOCHROME
P450

(Streptomyces
peucetius) 		PF00067
(p450) 		5 LEU A  58
GLY A 287
LEU A 339
ALA A 316
PHE A  39
 None
 1.23A 4wnuA-5it1A:
32.7		 4wnuA-5it1A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kre LYSOPHOSPHOLIPASE-LI
KE PROTEIN 1

(Homo sapiens) 		PF02230
(Abhydrolase_2) 		5 LEU A 194
PHE A 150
LEU A 171
ALA A 146
PHE A  78
 None
NO3  A 302 (-4.4A)
None
None
None
 1.08A 4wnuA-5kreA:
undetectable		 4wnuA-5kreA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot4 INTERAPTIN

(Legionella
pneumophila) 		no annotation 5 LEU A  40
GLY A 119
LEU A 120
LEU A  36
ALA A  23
 None
 1.20A 4wnuA-5ot4A:
undetectable		 4wnuA-5ot4A:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 263
LEU A 322
GLU A 321
LEU A 268
ALA A 432
 None
 1.12A 4wnuA-5toaA:
undetectable		 4wnuA-5toaA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tro PENICILLIN-BINDING
PROTEIN 1

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LEU A 242
GLY A 198
LEU A 197
GLU A 200
ALA A 177
 None
 1.18A 4wnuA-5troA:
undetectable		 4wnuA-5troA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuc SUS TBC1D15 GAP
DOMAIN

(Sus scrofa) 		PF00566
(RabGAP-TBC) 		5 GLY A 438
LEU A 516
GLN A 437
LEU A 393
PHE A 512
 None
 1.18A 4wnuA-5tucA:
undetectable		 4wnuA-5tucA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wze AMINOPEPTIDASE P

(Pseudomonas
aeruginosa) 		no annotation 5 LEU A 168
GLU A  21
LEU A  16
ALA A  26
SER A  24
 None
 1.19A 4wnuA-5wzeA:
undetectable		 4wnuA-5wzeA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xqo PCRGLX PROTEIN

(Penicillium
chrysogenum) 		no annotation 5 LEU A 789
PHE A 706
GLY A 750
LEU A 747
SER A 755
 None
 0.98A 4wnuA-5xqoA:
undetectable		 4wnuA-5xqoA:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y5a KLLA0F20702P

(Kluyveromyces
lactis) 		no annotation 5 LEU A 291
GLY A 323
LEU A 279
ALA A 256
PHE A 430
 None
 1.13A 4wnuA-5y5aA:
1.9		 4wnuA-5y5aA:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zgb LHCR1
LHCR2

(Cyanidioschyzon
merolae) 		no annotation 5 LEU 1   6
PHE 1  30
GLY 2 121
LEU 2 122
PHE 2 118
 CLA  1 601 (-4.0A)
CLA  1 602 ( 3.7A)
None
CLA  2 607 ( 4.8A)
None
 1.09A 4wnuA-5zgb1:
undetectable		 4wnuA-5zgb1:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6caj TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT BETA

(Homo sapiens) 		no annotation 5 LEU C 144
GLY C  40
LEU C  41
LEU C 140
PHE C  18
 None
 0.96A 4wnuA-6cajC:
1.4		 4wnuA-6cajC:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d21 FERM, RHOGEF AND
PLECKSTRIN DOMAIN
PROTEIN 2

(Danio rerio) 		no annotation 5 LEU A 123
GLY A  57
LEU A  58
GLN A  56
SER A 127
 None
 1.07A 4wnuA-6d21A:
undetectable		 4wnuA-6d21A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ej2 BETA-SECRETASE 1

(Homo sapiens) 		no annotation 5 LEU A 542
GLY A 529
LEU A 530
PHE A 447
ALA A 506
 None
 1.21A 4wnuA-6ej2A:
undetectable		 4wnuA-6ej2A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ffh METABOTROPIC
GLUTAMATE RECEPTOR
5,ENDOLYSIN

(Escherichia
virus T4;
Homo sapiens) 		no annotation 5 GLY A 628
LEU A 630
LEU A1814
ALA A 593
PHE A 633
 D7W  A4006 (-3.4A)
YCM  A 634 ( 4.2A)
None
None
OLA  A4004 (-4.8A)
 1.17A 4wnuA-6ffhA:
undetectable		 4wnuA-6ffhA:
9.19