SIMILAR PATTERNS OF AMINO ACIDS FOR 4WKQ_A_IREA1101

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ALA A 220
LYS A 222
GLU A 236
MET A 240
THR A 266
GLY A 272
ASP A 276
LEU A 321
 None
 0.69A 4wkqA-1k9aA:
32.0		 4wkqA-1k9aA:
25.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 267
ALA A 288
GLU A 305
THR A 334
GLY A 340
ASP A 344
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
 0.88A 4wkqA-1opkA:
32.1		 4wkqA-1opkA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 LEU A 267
ALA A 288
LYS A 290
GLU A 305
MET A 309
THR A 334
GLY A 340
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.76A 4wkqA-1opkA:
32.1		 4wkqA-1opkA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 ALA A 230
LYS A 232
GLU A 245
LEU A 278
GLY A 286
LEU A 340
 PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-3.8A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
 0.55A 4wkqA-1py5A:
27.4		 4wkqA-1py5A:
24.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 595
ALA A 621
LYS A 623
GLU A 640
THR A 670
GLY A 676
LEU A 799
 STI  A   3 ( 3.8A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
 0.69A 4wkqA-1t46A:
30.6		 4wkqA-1t46A:
31.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 344
ALA A 367
GLU A 386
MET A 390
LEU A 412
GLY A 420
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-3.2A)
None
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.81A 4wkqA-1u59A:
33.9		 4wkqA-1u59A:
33.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  15
ALA A  36
LYS A  38
GLU A  55
LEU A  82
GLY A  90
ASP A  94
LEU A 137
 HYM  A 400 (-4.2A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
None
None
None
HYM  A 400 (-4.5A)
 0.80A 4wkqA-1zltA:
23.9		 4wkqA-1zltA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  19
ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
 None
GOL  A3001 (-3.5A)
None
None
None
None
 0.37A 4wkqA-2a2aA:
25.5		 4wkqA-2a2aA:
25.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		6 LEU A  19
ALA A  40
LYS A  42
GLU A  60
LEU A  87
LEU A  91
 None
 0.53A 4wkqA-2bdwA:
23.8		 4wkqA-2bdwA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  26
ALA A  47
LYS A  49
GLU A  65
LEU A  96
GLY A 104
LEU A 155
 STU  A1301 (-4.2A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
None
None
STU  A1301 ( 4.0A)
STU  A1301 ( 4.8A)
 0.75A 4wkqA-2bujA:
25.0		 4wkqA-2bujA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csn CASEIN KINASE-1

(Schizosaccharomyces
pombe) 		PF00069
(Pkinase) 		7 ALA A  39
LYS A  41
GLU A  55
LEU A  83
LEU A  87
GLY A  89
LEU A 138
 CKI  A 300 (-3.6A)
None
None
None
None
None
CKI  A 300 (-4.4A)
 1.27A 4wkqA-2csnA:
22.3		 4wkqA-2csnA:
23.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU X  17
ALA X  37
LYS X  39
GLU X  54
MET X  58
THR X  82
GLY X  88
ASP X  92
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
None
STU  X 902 (-4.4A)
 0.70A 4wkqA-2dq7X:
33.7		 4wkqA-2dq7X:
33.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 LEU A  19
ALA A  40
LYS A  42
GLU A  59
LEU A  95
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
ADP  A 500 ( 4.9A)
ADP  A 500 (-4.3A)
 0.46A 4wkqA-2f9gA:
23.0		 4wkqA-2f9gA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
ALA A 293
LYS A 295
THR A 338
GLY A 344
ASP A 348
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.1A)
H8H  A 534 (-3.3A)
None
H8H  A 534 (-4.5A)
 0.57A 4wkqA-2h8hA:
29.8		 4wkqA-2h8hA:
22.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 251
ALA A 271
LYS A 273
GLU A 288
MET A 292
THR A 316
GLY A 322
ASP A 326
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.5A)
None
1BM  A 499 (-4.4A)
 0.63A 4wkqA-2hk5A:
33.3		 4wkqA-2hk5A:
34.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 248
ALA A 269
LYS A 271
GLU A 286
MET A 290
THR A 315
GLY A 321
LEU A 370
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-3.4A)
None
GIN  A 600 (-4.7A)
 0.76A 4wkqA-2hz0A:
31.0		 4wkqA-2hz0A:
36.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 248
ALA A 269
LYS A 271
GLU A 286
THR A 315
GLY A 321
ASP A 325
LEU A 370
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
None
None
GIN  A 600 (-4.7A)
 0.82A 4wkqA-2hz0A:
31.0		 4wkqA-2hz0A:
36.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 251
ALA A 271
LYS A 273
GLU A 288
MET A 292
THR A 316
GLY A 322
ASP A 326
LEU A 371
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.5A)
None
1N8  A 501 ( 4.3A)
 0.84A 4wkqA-2og8A:
29.2		 4wkqA-2og8A:
33.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		10 LEU A  25
ALA A  46
LYS A  48
GLU A  73
LEU A 101
LEU A 105
GLY A 109
ASP A 113
LEU A 156
THR A 166
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
None
None
ATP  A 381 ( 4.8A)
ATP  A 381 ( 4.6A)
 0.73A 4wkqA-2phkA:
24.6		 4wkqA-2phkA:
26.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 215
LYS A 217
GLU A 230
LEU A 263
GLY A 271
ASP A 275
LEU A 328
 ADE  A 488 (-3.2A)
None
None
None
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
 0.69A 4wkqA-2qluA:
26.8		 4wkqA-2qluA:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 215
LYS A 217
THR A 265
GLY A 271
ASP A 275
LEU A 328
 ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
 0.52A 4wkqA-2qluA:
26.8		 4wkqA-2qluA:
24.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 LEU A 724
ALA A 749
LYS A 751
LEU A 794
THR A 796
LEU A 798
GLY A 802
LEU A 850
THR A 860
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.1A)
GW7  A   1 (-4.0A)
GW7  A   1 (-4.5A)
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
GW7  A   1 (-3.5A)
 0.60A 4wkqA-2r4bA:
36.4		 4wkqA-2r4bA:
73.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  19
ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
 ADP  A1303 ( 3.9A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
ADP  A1303 ( 4.8A)
None
None
 0.40A 4wkqA-2w4kA:
25.4		 4wkqA-2w4kA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 226
ALA A 247
LEU A 303
GLY A 307
ASP A 311
LEU A 354
THR A 367
 XK9  A1511 (-3.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.1A)
XK9  A1511 ( 3.7A)
None
XK9  A1511 (-4.6A)
XK9  A1511 (-3.7A)
 0.52A 4wkqA-2xk9A:
21.5		 4wkqA-2xk9A:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A 226
ALA A 247
LYS A 249
LEU A 303
GLY A 307
LEU A 354
THR A 367
 XK9  A1511 (-3.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
XK9  A1511 (-4.1A)
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
XK9  A1511 (-3.7A)
 0.90A 4wkqA-2xk9A:
21.5		 4wkqA-2xk9A:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  51
LYS A  53
LEU A 105
LEU A 109
GLY A 113
ASP A 117
LEU A 160
 B49  A1294 (-3.2A)
None
None
B49  A1294 ( 4.7A)
B49  A1294 (-3.6A)
None
B49  A1294 (-4.4A)
 0.49A 4wkqA-2y7jA:
25.5		 4wkqA-2y7jA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		6 LEU A  19
ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
 AMP  A1302 (-3.7A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
None
AMP  A1302 ( 4.9A)
 0.46A 4wkqA-2yabA:
25.5		 4wkqA-2yabA:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7r RIBOSOMAL PROTEIN S6
KINASE ALPHA-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  68
ALA A  92
LYS A  94
LEU A 139
GLY A 147
LEU A 194
THR A 204
 STU  A   1 (-3.8A)
STU  A   1 (-3.3A)
STU  A   1 (-2.8A)
None
STU  A   1 ( 3.9A)
STU  A   1 (-4.6A)
STU  A   1 (-3.6A)
 0.80A 4wkqA-2z7rA:
21.9		 4wkqA-2z7rA:
27.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1002
ALA A1028
LYS A1030
GLU A1047
MET A1051
LEU A1078
GLY A1082
 S91  A   1 ( 4.1A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.2A)
None
None
S91  A   1 (-4.7A)
S91  A   1 (-3.3A)
 0.68A 4wkqA-2z8cA:
32.1		 4wkqA-2z8cA:
32.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 253
ALA A 273
LYS A 275
MET A 294
GLY A 325
ASP A 329
LEU A 374
 None
 0.70A 4wkqA-2zv7A:
32.4		 4wkqA-2zv7A:
33.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 253
ALA A 273
MET A 294
THR A 319
GLY A 325
ASP A 329
LEU A 374
 None
 0.80A 4wkqA-2zv7A:
32.4		 4wkqA-2zv7A:
33.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 487
ALA A 515
LYS A 517
GLU A 534
MET A 538
GLY A 570
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.95A 4wkqA-3b2tA:
33.5		 4wkqA-3b2tA:
31.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  19
ALA A  40
LYS A  42
GLU A  64
LEU A  91
LEU A  95
 4RB  A 401 ( 3.9A)
4RB  A 401 (-3.3A)
4RB  A 401 ( 2.8A)
GOL  A 503 (-2.8A)
None
4RB  A 401 (-4.4A)
 0.49A 4wkqA-3bqrA:
22.3		 4wkqA-3bqrA:
25.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 220
LYS A 222
GLU A 236
MET A 240
THR A 266
GLY A 272
ASP A 276
LEU A 321
 None
 0.69A 4wkqA-3d7uA:
32.6		 4wkqA-3d7uA:
34.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  44
ALA A  65
LYS A  67
GLU A  89
LEU A 118
ASP A 131
LEU A 174
 985  A   1 (-4.1A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 (-3.6A)
None
None
985  A   1 (-4.8A)
 0.81A 4wkqA-3f2aA:
23.7		 4wkqA-3f2aA:
24.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fzp PROTEIN TYROSINE
KINASE 2 BETA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 431
ALA A 455
LYS A 457
GLU A 474
LEU A 504
GLY A 508
LEU A 556
 AGS  A 999 ( 4.4A)
AGS  A 999 (-3.6A)
AGS  A 999 (-2.5A)
AGS  A 999 (-3.6A)
AGS  A 999 (-4.4A)
None
AGS  A 999 (-4.5A)
 0.88A 4wkqA-3fzpA:
31.3		 4wkqA-3fzpA:
35.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kex RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 696
LYS A 723
LEU A 766
THR A 768
GLY A 774
ASP A 778
LEU A 822
 ANP  A   1 (-4.4A)
ANP  A   1 (-3.4A)
None
ANP  A   1 ( 4.8A)
ANP  A   1 ( 4.9A)
None
ANP  A   1 (-4.7A)
 0.61A 4wkqA-3kexA:
32.4		 4wkqA-3kexA:
54.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn5 RIBOSOMAL PROTEIN S6
KINASE ALPHA-5

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 432
ALA A 453
LYS A 455
GLU A 468
LEU A 496
LEU A 500
 ANP  A 400 (-4.1A)
ANP  A 400 ( 3.8A)
None
None
None
ANP  A 400 (-4.6A)
 0.49A 4wkqA-3kn5A:
20.0		 4wkqA-3kn5A:
25.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ALA A 665
LYS A 667
GLU A 684
MET A 688
THR A 713
GLY A 719
LEU A 767
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
 0.64A 4wkqA-3kulA:
34.6		 4wkqA-3kulA:
32.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		7 LEU A 680
ALA A 700
LYS A 702
GLU A 715
LEU A 747
ASP A 754
LEU A 804
 ADP  A2101 ( 4.1A)
ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
None
None
ADP  A2101 ( 4.9A)
ADP  A2101 (-4.4A)
 0.78A 4wkqA-3lj0A:
24.6		 4wkqA-3lj0A:
26.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 719
LEU A 764
THR A 766
LEU A 768
GLY A 772
ASP A 776
LEU A 820
THR A 830
 ITI  A   1 (-2.9A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-3.5A)
None
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
 0.88A 4wkqA-3lzbA:
34.6		 4wkqA-3lzbA:
86.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 694
ALA A 719
LEU A 764
THR A 766
LEU A 768
GLY A 772
ASP A 776
 ITI  A   1 (-3.9A)
ITI  A   1 (-2.9A)
ITI  A   1 ( 4.2A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-3.5A)
None
 0.98A 4wkqA-3lzbA:
34.6		 4wkqA-3lzbA:
86.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 753
THR A 766
LEU A 768
GLY A 772
ASP A 776
LEU A 820
THR A 830
 ITI  A   1 (-3.8A)
ITI  A   1 (-3.8A)
ITI  A   1 (-4.8A)
ITI  A   1 (-3.5A)
None
ITI  A   1 (-4.6A)
ITI  A   1 (-3.8A)
 1.42A 4wkqA-3lzbA:
34.6		 4wkqA-3lzbA:
86.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		8 LEU A  88
ALA A 109
LYS A 111
GLU A 130
MET A 134
GLY A 165
LEU A 212
THR A 222
 JOZ  A 361 (-4.1A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
SO4  A   5 (-3.1A)
None
None
None
JOZ  A 361 (-3.7A)
 0.78A 4wkqA-3nuuA:
24.5		 4wkqA-3nuuA:
27.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		8 LEU A 192
ALA A 213
LYS A 215
GLU A 234
LEU A 261
LEU A 265
GLY A 269
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
AMP  A 577 ( 4.9A)
None
AMP  A 577 (-4.8A)
 0.54A 4wkqA-3nyoA:
24.4		 4wkqA-3nyoA:
19.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 LEU A 726
ALA A 751
LYS A 753
LEU A 796
THR A 798
LEU A 800
GLY A 804
ASP A 808
LEU A 852
THR A 862
 03Q  A   1 (-3.8A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.3A)
03Q  A   1 (-4.1A)
03Q  A   1 (-4.6A)
03Q  A   1 ( 3.9A)
None
03Q  A   1 (-4.4A)
03Q  A   1 (-3.3A)
 0.52A 4wkqA-3pp0A:
39.2		 4wkqA-3pp0A:
78.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 ALA A 576
LYS A 578
GLU A 596
MET A 600
THR A 625
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.78A 4wkqA-3ppzA:
30.7		 4wkqA-3ppzA:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 345
LYS A 368
GLU A 384
MET A 388
THR A 413
GLY A 419
LEU A 467
 STU  A   1 (-3.8A)
STU  A   1 (-3.1A)
STU  A   1 (-3.7A)
None
STU  A   1 (-3.9A)
STU  A   1 (-3.6A)
STU  A   1 (-4.6A)
 0.97A 4wkqA-3s95A:
26.8		 4wkqA-3s95A:
28.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1951
ALA A1978
LYS A1980
MET A2001
LEU A2028
GLY A2032
LEU A2086
 VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
VGH  A3000 ( 4.8A)
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
 0.63A 4wkqA-3zbfA:
32.7		 4wkqA-3zbfA:
34.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 ALA A 104
LYS A 106
GLU A 125
LEU A 152
GLY A 160
LEU A 208
THR A 138
 EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
None
None
EDO  A1420 ( 4.8A)
None
 1.43A 4wkqA-4aw2A:
22.5		 4wkqA-4aw2A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		7 LEU A 246
ALA A 267
LYS A 269
GLU A 288
GLY A 324
LEU A 371
THR A 381
 None
 0.84A 4wkqA-4c0tA:
23.4		 4wkqA-4c0tA:
15.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
ALA A 653
LYS A 655
GLU A 672
MET A 676
THR A 701
LEU A 773
 None
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.5A)
 0.93A 4wkqA-4ckrA:
28.8		 4wkqA-4ckrA:
32.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 377
ALA A 400
LYS A 402
GLU A 420
MET A 424
LEU A 446
GLY A 454
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
 0.62A 4wkqA-4f4pA:
34.8		 4wkqA-4f4pA:
39.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		6 LEU A 377
ALA A 400
LYS A 402
LEU A 446
GLY A 454
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 (-3.3A)
ANP  A 701 (-2.7A)
None
ANP  A 701 ( 4.2A)
ANP  A 701 (-4.5A)
 0.49A 4wkqA-4fl3A:
29.4		 4wkqA-4fl3A:
21.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A1122
ALA A1148
LYS A1150
GLU A1167
LEU A1198
GLY A1202
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
0UV  A1501 ( 4.8A)
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.81A 4wkqA-4fodA:
30.8		 4wkqA-4fodA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 855
ALA A 880
LYS A 882
GLU A 898
LEU A 927
GLY A 935
ASP A 939
LEU A 983
 IZA  A2001 (-3.7A)
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
None
IZA  A2001 (-3.3A)
None
IZA  A2001 ( 4.7A)
 0.76A 4wkqA-4gl9A:
33.0		 4wkqA-4gl9A:
34.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 828
ALA A 853
LYS A 855
GLU A 871
LEU A 900
GLY A 908
ASP A 912
LEU A 956
 19S  A1201 (-3.9A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
19S  A1201 ( 3.8A)
None
19S  A1201 (-4.5A)
 0.96A 4wkqA-4hviA:
34.2		 4wkqA-4hviA:
34.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		8 LEU A 132
ALA A 156
LYS A 158
THR A 205
LEU A 207
GLY A 211
ASP A 215
LEU A 259
 None
 0.73A 4wkqA-4hzsA:
28.6		 4wkqA-4hzsA:
36.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 132
ALA A 156
GLU A 177
THR A 205
LEU A 207
GLY A 211
ASP A 215
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-3.6A)
1G0  A 401 ( 4.5A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-4.6A)
 1.03A 4wkqA-4id7A:
34.4		 4wkqA-4id7A:
35.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 132
ALA A 156
LYS A 158
THR A 205
LEU A 207
GLY A 211
ASP A 215
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.9A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-4.6A)
 0.74A 4wkqA-4id7A:
34.4		 4wkqA-4id7A:
35.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
ALA A 293
LYS A 295
GLY A 344
ASP A 348
LEU A 393
 0J9  A 601 (-4.0A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
0J9  A 601 ( 4.1A)
None
0J9  A 601 (-4.5A)
 0.51A 4wkqA-4k11A:
29.4		 4wkqA-4k11A:
25.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 478
ALA A 506
LYS A 508
GLU A 525
MET A 529
GLY A 561
LEU A 624
 ACP  A 801 (-3.8A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
 0.60A 4wkqA-4k33A:
35.0		 4wkqA-4k33A:
32.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 273
ALA A 293
LYS A 295
MET A 314
GLY A 344
ASP A 348
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 3.2A)
None
VGG  A 601 (-4.5A)
 0.61A 4wkqA-4lggA:
29.3		 4wkqA-4lggA:
32.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		7 LEU A  78
ALA A  99
LYS A 101
GLU A 117
MET A 121
LEU A 144
LEU A 148
 STU  A 601 ( 4.0A)
STU  A 601 (-3.3A)
STU  A 601 (-3.9A)
None
None
None
STU  A 601 (-4.3A)
 0.69A 4wkqA-4mvfA:
15.9		 4wkqA-4mvfA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		10 LEU A  46
ALA A  67
LYS A  69
GLU A  85
MET A  89
LEU A 121
THR A 123
LEU A 125
GLY A 128
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
None
None
None
SIN  A 401 ( 4.8A)
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.65A 4wkqA-4o38A:
20.7		 4wkqA-4o38A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 903
ALA A 928
LYS A 930
GLU A 947
LEU A 976
GLY A 984
ASP A 988
LEU A1030
 2TT  A1202 (-3.5A)
2TT  A1202 ( 3.9A)
None
None
None
2TT  A1202 (-3.4A)
None
2TT  A1202 (-4.4A)
 0.99A 4wkqA-4oliA:
32.5		 4wkqA-4oliA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
ALA A 642
LYS A 644
GLU A 661
LEU A 689
GLY A 697
LEU A 818
 P30  A1001 (-3.8A)
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
None
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.70A 4wkqA-4rt7A:
30.1		 4wkqA-4rt7A:
28.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 LEU A  14
ALA A  35
LYS A  37
GLU A  52
MET A  56
GLY A  87
ASP A  91
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
 0.72A 4wkqA-4ueuA:
32.1		 4wkqA-4ueuA:
35.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 LEU A  14
ALA A  35
LYS A  37
MET A  56
THR A  81
GLY A  87
ASP A  91
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
 0.72A 4wkqA-4ueuA:
32.1		 4wkqA-4ueuA:
35.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 LEU A 193
ALA A 214
LYS A 216
GLU A 235
LEU A 262
GLY A 270
LEU A 321
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
None
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
 0.69A 4wkqA-4wboA:
21.2		 4wkqA-4wboA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 8 LEU B 267
ALA B 288
LYS B 290
MET B 309
THR B 334
GLY B 340
ASP B 344
LEU B 389
 1N1  B 601 (-3.7A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 (-3.7A)
1N1  B 601 (-3.3A)
1N1  B 601 (-3.5A)
None
1N1  B 601 (-4.3A)
 0.73A 4wkqA-4xeyB:
33.7		 4wkqA-4xeyB:
28.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 616
ALA A 642
LYS A 644
GLU A 661
LEU A 689
GLY A 697
LEU A 818
 P30  A1001 (-4.0A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.65A 4wkqA-4xufA:
29.2		 4wkqA-4xufA:
33.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		9 LEU A  34
ALA A  55
LYS A  57
GLU A  76
LEU A 103
THR A 105
GLY A 111
ASP A 115
LEU A 158
 ADP  A 506 ( 3.8A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
None
ADP  A 506 ( 4.6A)
None
None
ADP  A 506 (-4.7A)
 0.99A 4wkqA-4ysjA:
25.2		 4wkqA-4ysjA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci7 SERINE/THREONINE-PRO
TEIN KINASE ULK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  44
LYS A  46
GLU A  63
LEU A  90
GLY A  98
ASP A 102
LEU A 145
 51W  A 401 (-3.4A)
GOL  A 404 ( 3.1A)
None
None
51W  A 401 (-3.7A)
None
51W  A 401 (-4.5A)
 0.81A 4wkqA-5ci7A:
25.9		 4wkqA-5ci7A:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 275
LYS A 277
GLU A 290
LEU A 323
THR A 325
GLY A 331
LEU A 386
 STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
None
STU  A 601 ( 3.7A)
STU  A 601 (-3.5A)
STU  A 601 (-3.9A)
 0.61A 4wkqA-5e8yA:
26.8		 4wkqA-5e8yA:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyk AURORA KINASE B-A

(Xenopus laevis) 		PF00069
(Pkinase) 		6 LEU A  99
ALA A 120
LYS A 122
LEU A 168
GLY A 176
LEU A 223
 5U5  A 401 (-3.8A)
5U5  A 401 (-3.5A)
5U5  A 401 (-2.6A)
None
5U5  A 401 (-3.4A)
5U5  A 401 (-4.7A)
 0.55A 4wkqA-5eykA:
25.0		 4wkqA-5eykA:
24.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 903
ALA A 928
LYS A 930
GLU A 947
GLY A 984
ASP A 988
LEU A1030
 5U3  A1200 (-3.8A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-3.2A)
None
5U3  A1200 (-4.4A)
 0.60A 4wkqA-5f1zA:
32.6		 4wkqA-5f1zA:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 903
LYS A 930
GLU A 947
LEU A 976
GLY A 984
ASP A 988
LEU A1030
 5U3  A1200 (-3.8A)
None
None
None
5U3  A1200 (-3.2A)
None
5U3  A1200 (-4.4A)
 0.81A 4wkqA-5f1zA:
32.6		 4wkqA-5f1zA:
31.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 730
ALA A 756
LYS A 758
LEU A 802
GLY A 810
LEU A 881
 PP1  A2012 (-4.6A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
PTR  A 809 (-2.4A)
PP1  A2012 (-4.6A)
 0.49A 4wkqA-5fm2A:
33.2		 4wkqA-5fm2A:
30.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd CASEIN KINASE I
ISOFORM ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA C  44
LYS C  46
GLU C  60
LEU C  88
LEU C  92
GLY C  94
LEU C 143
 None
 1.36A 4wkqA-5fqdC:
21.8		 4wkqA-5fqdC:
23.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 599
ALA A 625
LYS A 627
GLU A 644
THR A 674
GLY A 680
LEU A 825
 748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.62A 4wkqA-5grnA:
30.0		 4wkqA-5grnA:
31.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		8 LEU A  20
ALA A  41
LYS A  43
GLU A  61
LEU A  88
LEU A  92
GLY A  96
LEU A 143
 ADP  A 301 ( 4.0A)
ADP  A 301 (-3.5A)
ADP  A 301 (-2.7A)
None
None
ADP  A 301 ( 4.8A)
None
ADP  A 301 (-4.7A)
 0.73A 4wkqA-5hu3A:
26.0		 4wkqA-5hu3A:
24.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  57
ALA A  77
LYS A  79
GLU A  95
MET A  99
GLY A 136
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.77A 4wkqA-5i3oA:
24.0		 4wkqA-5i3oA:
23.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 LEU A 718
ALA A 743
LYS A 745
GLU A 762
MET A 766
LEU A 788
LEU A 792
GLY A 796
ASP A 800
LEU A 844
THR A 854
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.6A)
6HJ  A1101 ( 4.9A)
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.8A)
6HJ  A1101 (-3.9A)
 0.45A 4wkqA-5j9zA:
42.7		 4wkqA-5j9zA:
98.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 417
GLU A 436
LEU A 463
LEU A 467
GLY A 471
ASP A 475
LEU A 518
 GUI  A 701 ( 3.9A)
None
None
GUI  A 701 ( 4.7A)
GUI  A 701 (-3.6A)
GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
 0.56A 4wkqA-5jznA:
24.5		 4wkqA-5jznA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 417
LYS A 419
GLU A 436
LEU A 463
GLY A 471
ASP A 475
LEU A 518
 GUI  A 701 ( 3.9A)
GUI  A 701 (-3.1A)
None
None
GUI  A 701 (-3.6A)
GUI  A 701 (-4.1A)
GUI  A 701 (-4.4A)
 0.71A 4wkqA-5jznA:
24.5		 4wkqA-5jznA:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A 297
LYS A 299
MET A 319
GLY A 350
ASP A 354
LEU A 396
THR A 406
 IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.1A)
IPW  A 601 ( 3.8A)
None
IPW  A 601 (-4.5A)
IPW  A 601 (-3.7A)
 0.84A 4wkqA-5kbrA:
24.1		 4wkqA-5kbrA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 209
ALA A 228
LYS A 230
GLU A 250
MET A 254
GLY A 289
LEU A 338
 None
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
6UY  A 501 (-4.3A)
None
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.5A)
 0.83A 4wkqA-5ko1A:
26.2		 4wkqA-5ko1A:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 ALA A 909
LYS A 911
GLU A 927
LEU A 954
GLY A 962
LEU A1016
 ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
 0.54A 4wkqA-5lpyA:
26.0		 4wkqA-5lpyA:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 ALA A 909
LYS A 911
GLU A 927
LEU A 954
GLY A 962
ASP A 966
LEU A1016
 ADP  A1200 (-3.5A)
ADP  A1200 ( 4.3A)
None
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.2A)
ADP  A1200 (-4.7A)
 0.68A 4wkqA-5lpzA:
25.9		 4wkqA-5lpzA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tur SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		no annotation 7 LEU A  44
ALA A  65
LYS A  67
GLU A  89
LEU A 118
ASP A 131
LEU A 174
 None
7LK  A 401 (-3.3A)
None
None
None
7LK  A 401 (-3.0A)
7LK  A 401 (-4.8A)
 0.68A 4wkqA-5turA:
23.9		 4wkqA-5turA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 7 LEU A 891
ALA A 917
LYS A 919
THR A 963
GLY A 969
LEU A1017
THR A1027
 ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
ANP  A1201 ( 4.9A)
 0.70A 4wkqA-5wnoA:
31.1		 4wkqA-5wnoA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 6 LEU A 881
ALA A 906
LYS A 908
GLU A 925
GLY A 962
LEU A1010
 ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-2.8A)
None
ADP  A1201 ( 4.1A)
ADP  A1201 (-4.5A)
 0.48A 4wkqA-6c7yA:
33.4		 4wkqA-6c7yA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ccf CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 1

(Homo sapiens) 		no annotation 6 ALA A 155
LYS A 157
LEU A 228
LEU A 232
GLY A 236
LEU A 282
 H1N  A 501 (-3.4A)
H1N  A 501 (-2.8A)
None
H1N  A 501 (-4.3A)
H1N  A 501 (-3.6A)
H1N  A 501 (-4.8A)
 0.34A 4wkqA-6ccfA:
24.0		 4wkqA-6ccfA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 7 LEU A 197
ALA A 217
LYS A 219
THR A 264
LEU A 266
GLY A 270
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.0A)
FKY  A9001 (-4.4A)
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.93A 4wkqA-6cz4A:
22.6		 4wkqA-6cz4A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 6 LEU A 169
ALA A 191
LYS A 193
GLU A 208
LEU A 245
ASP A 252
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
3NG  A 501 ( 4.9A)
3NG  A 501 ( 4.7A)
None
 0.53A 4wkqA-6fylA:
24.0		 4wkqA-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 7 LEU A 169
ALA A 191
LYS A 193
GLU A 208
LEU A 245
GLY A 247
LEU A 297
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
3NG  A 501 ( 4.9A)
3NG  A 501 ( 4.7A)
None
None
 1.10A 4wkqA-6fylA:
24.0		 4wkqA-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 7 LEU A 167
ALA A 189
LYS A 191
GLU A 206
LEU A 243
GLY A 245
LEU A 295
 EAQ  A 501 (-3.9A)
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
EAQ  A 501 ( 4.9A)
EAQ  A 501 (-3.9A)
EAQ  A 501 (-4.9A)
 1.18A 4wkqA-6fyoA:
23.7		 4wkqA-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 6 LEU A 167
ALA A 189
LYS A 191
GLU A 206
LEU A 243
ASP A 250
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
3NG  A 501 ( 4.7A)
None
 0.52A 4wkqA-6fyvA:
23.7		 4wkqA-6fyvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 7 LEU A 167
ALA A 189
LYS A 191
GLU A 206
LEU A 243
GLY A 245
LEU A 295
 3NG  A 501 (-3.9A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
3NG  A 501 ( 4.7A)
None
None
 1.18A 4wkqA-6fyvA:
23.7		 4wkqA-6fyvA:
undetectable