SIMILAR PATTERNS OF AMINO ACIDS FOR 4WG0_G_CHDG103
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aei | ANNEXIN XII (Hydra vulgaris) |
PF00191(Annexin) | 5 | LEU A 63LYS A 68LEU A 67LEU A 80ARG A 84 | None | 0.94A | 4wg0E-1aeiA:undetectable4wg0F-1aeiA:undetectable4wg0G-1aeiA:undetectable | 4wg0E-1aeiA:4.264wg0F-1aeiA:4.264wg0G-1aeiA:4.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aei | ANNEXIN XII (Hydra vulgaris) |
PF00191(Annexin) | 5 | LYS A 68LEU A 67LEU A 80ARG A 84LEU A 83 | None | 1.01A | 4wg0E-1aeiA:undetectable4wg0F-1aeiA:undetectable4wg0G-1aeiA:undetectable | 4wg0E-1aeiA:4.264wg0F-1aeiA:4.264wg0G-1aeiA:4.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1evj | GLUCOSE-FRUCTOSEOXIDOREDUCTASE (Zymomonasmobilis) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 5 | ALA A 75TYR A 77LEU A 39LEU A 44LEU A 48 | None | 0.91A | 4wg0E-1evjA:undetectable4wg0F-1evjA:undetectable4wg0G-1evjA:undetectable | 4wg0E-1evjA:4.564wg0F-1evjA:4.564wg0G-1evjA:4.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f51 | SPORULATIONINITIATIONPHOSPHOTRANSFERASE B (Bacillussubtilis) |
PF14682(SPOB_ab)PF14689(SPOB_a) | 5 | ALA A 111LEU A 110LEU A 137LEU A 71LEU A 103 | None | 0.96A | 4wg0E-1f51A:undetectable4wg0F-1f51A:undetectable4wg0G-1f51A:undetectable | 4wg0E-1f51A:5.454wg0F-1f51A:5.454wg0G-1f51A:5.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f51 | SPORULATIONINITIATIONPHOSPHOTRANSFERASE B (Bacillussubtilis) |
PF14682(SPOB_ab)PF14689(SPOB_a) | 5 | LEU A 137LEU A 110LEU A 191ARG A 144LEU A 146 | None | 0.97A | 4wg0E-1f51A:undetectable4wg0F-1f51A:undetectable4wg0G-1f51A:undetectable | 4wg0E-1f51A:5.454wg0F-1f51A:5.454wg0G-1f51A:5.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g59 | GLUTAMYL-TRNASYNTHETASE (Thermusthermophilus) |
PF00749(tRNA-synt_1c) | 5 | ALA A 452LEU A 451LEU A 401LEU A 415LEU A 416 | None | 0.94A | 4wg0E-1g59A:undetectable4wg0F-1g59A:undetectable4wg0G-1g59A:undetectable | 4wg0E-1g59A:2.184wg0F-1g59A:2.184wg0G-1g59A:2.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h6d | PRECURSOR FORM OFGLUCOSE-FRUCTOSEOXIDOREDUCTASE (Zymomonasmobilis) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 5 | ALA A 127TYR A 129LEU A 91LEU A 96LEU A 100 | NoneNoneNDP A 500 (-3.8A)NoneNone | 0.89A | 4wg0E-1h6dA:undetectable4wg0F-1h6dA:undetectable4wg0G-1h6dA:undetectable | 4wg0E-1h6dA:3.494wg0F-1h6dA:3.494wg0G-1h6dA:3.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jft | PURINE NUCLEOTIDESYNTHESIS REPRESSOR (Escherichiacoli) |
PF00356(LacI)PF13377(Peripla_BP_3) | 5 | LEU A 134TYR A 137GLU A 128LEU A 130LEU A 108 | None | 0.94A | 4wg0E-1jftA:undetectable4wg0F-1jftA:undetectable4wg0G-1jftA:undetectable | 4wg0E-1jftA:3.904wg0F-1jftA:3.904wg0G-1jftA:3.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m9i | ANNEXIN VI (Homo sapiens) |
PF00191(Annexin) | 5 | LEU A 444GLU A 460LEU A 462LEU A 501LEU A 489 | None | 0.88A | 4wg0E-1m9iA:undetectable4wg0F-1m9iA:undetectable4wg0G-1m9iA:undetectable | 4wg0E-1m9iA:1.984wg0F-1m9iA:1.984wg0G-1m9iA:1.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m9s | INTERNALIN B (Listeriamonocytogenes) |
PF08191(LRR_adjacent)PF09479(Flg_new)PF12354(Internalin_N)PF12799(LRR_4)PF13457(SH3_8) | 5 | LEU A 235LEU A 237ASN A 261LEU A 223LEU A 226 | None | 0.78A | 4wg0E-1m9sA:undetectable4wg0F-1m9sA:undetectable4wg0G-1m9sA:undetectable | 4wg0E-1m9sA:2.494wg0F-1m9sA:2.494wg0G-1m9sA:2.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nne | DNA MISMATCH REPAIRPROTEIN MUTS (Thermusaquaticus) |
PF00488(MutS_V)PF01624(MutS_I)PF05188(MutS_II)PF05190(MutS_IV)PF05192(MutS_III) | 5 | ALA A 351LEU A 352LEU A 517LEU A 375LEU A 378 | None | 1.00A | 4wg0E-1nneA:undetectable4wg0F-1nneA:undetectable4wg0G-1nneA:undetectable | 4wg0E-1nneA:3.444wg0F-1nneA:3.444wg0G-1nneA:3.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sif | UBIQUITIN (Homo sapiens) |
PF00240(ubiquitin) | 5 | LEU A 56GLU A 24LEU A 26LEU A 43LEU A 67 | None | 0.95A | 4wg0E-1sifA:undetectable4wg0F-1sifA:undetectable4wg0G-1sifA:undetectable | 4wg0E-1sifA:12.244wg0F-1sifA:12.244wg0G-1sifA:12.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tx4 | P50-RHOGAP (Homo sapiens) |
PF00620(RhoGAP) | 5 | LEU A 171TYR A 168LEU A 226LEU A 233LEU A 160 | None | 0.93A | 4wg0E-1tx4A:undetectable4wg0F-1tx4A:undetectable4wg0G-1tx4A:undetectable | 4wg0E-1tx4A:6.944wg0F-1tx4A:6.944wg0G-1tx4A:6.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uel | UV EXCISION REPAIRPROTEIN RAD23HOMOLOG B (Homo sapiens) |
PF00240(ubiquitin) | 6 | LEU A 59TYR A 62GLU A 28LYS A 27LEU A 26LEU A 46 | None | 1.35A | 4wg0E-1uelA:undetectable4wg0F-1uelA:undetectable4wg0G-1uelA:undetectable | 4wg0E-1uelA:8.424wg0F-1uelA:8.424wg0G-1uelA:8.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ym5 | HYPOTHETICAL 32.6KDA PROTEIN INDAP2-SLT2 INTERGENICREGION (Saccharomycescerevisiae) |
PF02567(PhzC-PhzF) | 5 | ALA A 233LEU A 234TYR A 237GLU A 254LEU A 166 | None | 1.00A | 4wg0E-1ym5A:undetectable4wg0F-1ym5A:undetectable4wg0G-1ym5A:undetectable | 4wg0E-1ym5A:4.144wg0F-1ym5A:4.144wg0G-1ym5A:4.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2au3 | DNA PRIMASE (Aquifexaeolicus) |
PF01807(zf-CHC2)PF08275(Toprim_N)PF13155(Toprim_2) | 5 | LEU A 152GLU A 158LYS A 157LEU A 156LEU A 171 | None | 0.91A | 4wg0E-2au3A:undetectable4wg0F-2au3A:undetectable4wg0G-2au3A:undetectable | 4wg0E-2au3A:2.464wg0F-2au3A:2.464wg0G-2au3A:2.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bex | RIBONUCLEASEINHIBITOR (Homo sapiens) |
PF13516(LRR_6) | 6 | ALA A 202LEU A 203GLU A 149LEU A 205LEU A 233LEU A 218 | None | 1.32A | 4wg0E-2bexA:undetectable4wg0F-2bexA:undetectable4wg0G-2bexA:undetectable | 4wg0E-2bexA:2.654wg0F-2bexA:2.654wg0G-2bexA:2.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c1u | DI-HAEM CYTOCHROME CPEROXIDASE (Paracoccuspantotrophus) |
PF00034(Cytochrom_C)PF03150(CCP_MauG) | 5 | GLU A 199LYS A 200LEU A 203ASN A 7LEU A 10 | None | 0.63A | 4wg0E-2c1uA:undetectable4wg0F-2c1uA:undetectable4wg0G-2c1uA:undetectable | 4wg0E-2c1uA:3.594wg0F-2c1uA:3.594wg0G-2c1uA:3.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2een | HYPOTHETICAL PROTEINPH1819 (Pyrococcushorikoshii) |
PF01928(CYTH) | 5 | ALA A 48LEU A 49GLU A 82LEU A 64LEU A 96 | None | 0.92A | 4wg0E-2eenA:undetectable4wg0F-2eenA:undetectable4wg0G-2eenA:undetectable | 4wg0E-2eenA:7.594wg0F-2eenA:7.594wg0G-2eenA:7.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2epk | N-ACETYL-BETA-D-GLUCOSAMINIDASE (Streptococcusgordonii) |
PF00728(Glyco_hydro_20) | 5 | GLU X 109ALA X 112LEU X 111LEU X 387LEU X 390 | None | 0.86A | 4wg0E-2epkX:undetectable4wg0F-2epkX:undetectable4wg0G-2epkX:undetectable | 4wg0E-2epkX:2.804wg0F-2epkX:2.804wg0G-2epkX:2.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f9t | PANTOTHENATE KINASE (Pseudomonasaeruginosa) |
PF03309(Pan_kinase) | 5 | ALA A 66LEU A 68LEU A 5LEU A 35LEU A 39 | None | 0.96A | 4wg0E-2f9tA:undetectable4wg0F-2f9tA:undetectable4wg0G-2f9tA:undetectable | 4wg0E-2f9tA:3.854wg0F-2f9tA:3.854wg0G-2f9tA:3.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g2b | ALLOGRAFTINFLAMMATORY FACTOR1 (Homo sapiens) |
no annotation | 6 | LEU A 46TYR A 40GLU A 51LEU A 110ARG A 111LEU A 114 | None | 1.49A | 4wg0E-2g2bA:undetectable4wg0F-2g2bA:undetectable4wg0G-2g2bA:undetectable | 4wg0E-2g2bA:8.264wg0F-2g2bA:8.264wg0G-2g2bA:8.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hi4 | CYTOCHROME P450 1A2 (Homo sapiens) |
PF00067(p450) | 5 | LEU A 172GLU A 178LEU A 176LEU A 479LEU A 475 | None | 0.99A | 4wg0E-2hi4A:undetectable4wg0F-2hi4A:undetectable4wg0G-2hi4A:undetectable | 4wg0E-2hi4A:3.514wg0F-2hi4A:3.514wg0G-2hi4A:3.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hiy | HYPOTHETICAL PROTEIN (Streptococcuspneumoniae) |
PF08002(DUF1697) | 5 | ALA A 5LEU A 6LEU A 24ARG A 25LEU A 28 | None | 0.91A | 4wg0E-2hiyA:undetectable4wg0F-2hiyA:undetectable4wg0G-2hiyA:undetectable | 4wg0E-2hiyA:5.624wg0F-2hiyA:5.624wg0G-2hiyA:5.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iel | HYPOTHETICAL PROTEINTT0030 (Thermusthermophilus) |
no annotation | 5 | LEU A 17GLU A 23LYS A 22LEU A 21LEU A 67 | None | 0.82A | 4wg0E-2ielA:undetectable4wg0F-2ielA:undetectable4wg0G-2ielA:undetectable | 4wg0E-2ielA:20.694wg0F-2ielA:20.694wg0G-2ielA:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2in3 | HYPOTHETICAL PROTEIN (Nitrosomonaseuropaea) |
PF01323(DSBA) | 6 | LEU A 8TYR A 33LEU A 178LEU A 199ARG A 200LEU A 203 | None | 1.20A | 4wg0E-2in3A:undetectable4wg0F-2in3A:undetectable4wg0G-2in3A:undetectable | 4wg0E-2in3A:4.784wg0F-2in3A:4.784wg0G-2in3A:4.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jh3 | RIBOSOMAL PROTEINS2-RELATED PROTEIN (Deinococcusradiodurans) |
PF01903(CbiX) | 5 | ALA A 229LEU A 226LEU A 222LEU A 146LEU A 207 | None | 0.98A | 4wg0E-2jh3A:undetectable4wg0F-2jh3A:undetectable4wg0G-2jh3A:undetectable | 4wg0E-2jh3A:2.494wg0F-2jh3A:2.494wg0G-2jh3A:2.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jqd | ACIDIC LEUCINE-RICHNUCLEARPHOSPHOPROTEIN 32FAMILY MEMBER A (Mus musculus) |
PF14580(LRR_9) | 5 | LEU A 60LEU A 69ASN A 89LEU A 90LEU A 83 | None | 0.98A | 4wg0E-2jqdA:undetectable4wg0F-2jqdA:undetectable4wg0G-2jqdA:undetectable | 4wg0E-2jqdA:6.374wg0F-2jqdA:6.374wg0G-2jqdA:6.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jzk | CYANOVIRIN-N HOMOLOG (Tuber borchii) |
PF08881(CVNH) | 5 | LEU A 12GLU A 34LEU A 19LEU A 37LEU A 71 | None | 0.98A | 4wg0E-2jzkA:undetectable4wg0F-2jzkA:undetectable4wg0G-2jzkA:undetectable | 4wg0E-2jzkA:19.054wg0F-2jzkA:19.054wg0G-2jzkA:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lak | AHSA1-LIKE PROTEINRHE_CH02687 (Rhizobium etli) |
PF08327(AHSA1) | 5 | ALA A 18LEU A 17GLU A 136LEU A 134LEU A 27 | None | 0.93A | 4wg0E-2lakA:undetectable4wg0F-2lakA:undetectable4wg0G-2lakA:undetectable | 4wg0E-2lakA:8.164wg0F-2lakA:8.164wg0G-2lakA:8.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ngr | PROTEIN (GTPASEACTIVATING PROTEIN(RHG)) (Homo sapiens) |
PF00620(RhoGAP) | 5 | LEU B 391TYR B 388LEU B 446LEU B 453LEU B 380 | None | 0.90A | 4wg0E-2ngrB:undetectable4wg0F-2ngrB:undetectable4wg0G-2ngrB:undetectable | 4wg0E-2ngrB:5.974wg0F-2ngrB:5.974wg0G-2ngrB:5.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2omv | INTERNALIN-A (Listeriamonocytogenes) |
PF08191(LRR_adjacent)PF12354(Internalin_N)PF12799(LRR_4) | 5 | LEU A 410LEU A 412ASN A 436LEU A 398LEU A 401 | None | 0.91A | 4wg0E-2omvA:undetectable4wg0F-2omvA:undetectable4wg0G-2omvA:undetectable | 4wg0E-2omvA:4.764wg0F-2omvA:4.764wg0G-2omvA:4.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p0t | UPF0307 PROTEINPSPTO_4464 (Pseudomonassyringae groupgenomosp. 3) |
PF04751(DUF615) | 6 | ALA A 56LEU A 53GLU A 30LEU A 32LEU A 35LEU A 40 | None | 1.21A | 4wg0E-2p0tA:undetectable4wg0F-2p0tA:undetectable4wg0G-2p0tA:undetectable | 4wg0E-2p0tA:6.474wg0F-2p0tA:6.474wg0G-2p0tA:6.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pqq | PUTATIVETRANSCRIPTIONALREGULATOR (Streptomycescoelicolor) |
PF00027(cNMP_binding) | 5 | GLU A 98ALA A 32LEU A 31GLU A 52LEU A 101 | None | 0.93A | 4wg0E-2pqqA:undetectable4wg0F-2pqqA:undetectable4wg0G-2pqqA:undetectable | 4wg0E-2pqqA:7.194wg0F-2pqqA:7.194wg0G-2pqqA:7.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q01 | URONATE ISOMERASE (Caulobactervibrioides) |
PF02614(UxaC) | 5 | GLU A 280LYS A 281LEU A 284LEU A 268LEU A 260 | None | 0.99A | 4wg0E-2q01A:undetectable4wg0F-2q01A:undetectable4wg0G-2q01A:undetectable | 4wg0E-2q01A:2.114wg0F-2q01A:2.114wg0G-2q01A:2.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wb1 | DNA-DIRECTED RNAPOLYMERASERPO3SUBUNIT (Sulfolobusshibatae) |
PF01000(RNA_pol_A_bac)PF01193(RNA_pol_L) | 5 | LEU D 230GLU D 239LEU D 242LEU D 15LEU D 228 | None | 0.93A | 4wg0E-2wb1D:undetectable4wg0F-2wb1D:undetectable4wg0G-2wb1D:undetectable | 4wg0E-2wb1D:3.854wg0F-2wb1D:3.854wg0G-2wb1D:3.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wqw | INTERNALIN B (Listeriamonocytogenes) |
PF08191(LRR_adjacent)PF12354(Internalin_N)PF12799(LRR_4) | 6 | ALA A 307LEU A 235LEU A 237ASN A 261LEU A 223LEU A 226 | None | 1.18A | 4wg0E-2wqwA:undetectable4wg0F-2wqwA:undetectable4wg0G-2wqwA:undetectable | 4wg0E-2wqwA:9.004wg0F-2wqwA:9.004wg0G-2wqwA:9.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xzo | REGULATOR OFNONSENSE TRANSCRIPTS1 (Homo sapiens) |
PF04851(ResIII)PF13086(AAA_11)PF13087(AAA_12) | 5 | LEU A 659GLU A 686LEU A 688ARG A 485LEU A 487 | None | 0.95A | 4wg0E-2xzoA:undetectable4wg0F-2xzoA:undetectable4wg0G-2xzoA:undetectable | 4wg0E-2xzoA:2.394wg0F-2xzoA:2.394wg0G-2xzoA:2.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y5q | INTERNALIN B (Listeriamonocytogenes) |
PF08191(LRR_adjacent)PF12354(Internalin_N)PF12799(LRR_4) | 6 | ALA A 307LEU A 235LEU A 237ASN A 261LEU A 223LEU A 226 | None | 1.22A | 4wg0E-2y5qA:undetectable4wg0F-2y5qA:undetectable4wg0G-2y5qA:undetectable | 4wg0E-2y5qA:8.574wg0F-2y5qA:8.574wg0G-2y5qA:8.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yqy | HYPOTHETICAL PROTEINTTHA0303 (Thermusthermophilus) |
PF12867(DinB_2) | 5 | LEU A 24GLU A 30LEU A 28LEU A 110LEU A 113 | None | 1.00A | 4wg0E-2yqyA:undetectable4wg0F-2yqyA:undetectable4wg0G-2yqyA:undetectable | 4wg0E-2yqyA:8.534wg0F-2yqyA:8.534wg0G-2yqyA:8.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yu1 | JMJCDOMAIN-CONTAININGHISTONEDEMETHYLATIONPROTEIN 1A (Homo sapiens) |
PF02373(JmjC) | 5 | LEU A 453GLU A 459LEU A 461LEU A 496LEU A 495 | None | 0.99A | 4wg0E-2yu1A:undetectable4wg0F-2yu1A:undetectable4wg0G-2yu1A:undetectable | 4wg0E-2yu1A:2.864wg0F-2yu1A:2.864wg0G-2yu1A:2.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yv7 | CG10997-PA (Drosophilamelanogaster) |
no annotation | 5 | ALA A 203LEU A 204TYR A 207LEU A 151LEU A 182 | None | 0.96A | 4wg0E-2yv7A:undetectable4wg0F-2yv7A:undetectable4wg0G-2yv7A:undetectable | 4wg0E-2yv7A:4.654wg0F-2yv7A:4.654wg0G-2yv7A:4.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cbg | O-METHYLTRANSFERASE (Synechocystissp. PCC 6803) |
PF01596(Methyltransf_3) | 5 | GLU A 126LEU A 128ASN A 158LEU A 159LEU A 65 | None | 1.00A | 4wg0E-3cbgA:undetectable4wg0F-3cbgA:undetectable4wg0G-3cbgA:undetectable | 4wg0E-3cbgA:5.334wg0F-3cbgA:5.334wg0G-3cbgA:5.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gf9 | INTERSECTIN 2 (Homo sapiens) |
PF00621(RhoGEF) | 5 | LEU A1189LEU A1263ASN A1236LEU A1239LEU A1243 | None | 0.88A | 4wg0E-3gf9A:undetectable4wg0F-3gf9A:undetectable4wg0G-3gf9A:undetectable | 4wg0E-3gf9A:3.734wg0F-3gf9A:3.734wg0G-3gf9A:3.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ker | D-DOPACHROMEDECARBOXYLASE (Mus musculus) |
PF01187(MIF) | 5 | GLU A 19LEU A 22LEU A 5LEU A 88LEU A 84 | None | 1.00A | 4wg0E-3kerA:undetectable4wg0F-3kerA:undetectable4wg0G-3kerA:undetectable | 4wg0E-3kerA:10.644wg0F-3kerA:10.644wg0G-3kerA:10.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kqf | ENOYL-COAHYDRATASE/ISOMERASEFAMILY PROTEIN (Bacillusanthracis) |
PF00378(ECH_1) | 5 | GLU A 116ALA A 120LEU A 117LEU A 30LEU A 35 | None | 0.99A | 4wg0E-3kqfA:undetectable4wg0F-3kqfA:undetectable4wg0G-3kqfA:undetectable | 4wg0E-3kqfA:4.864wg0F-3kqfA:4.864wg0G-3kqfA:4.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3m0g | FARNESYL DIPHOSPHATESYNTHASE (Rhodobactercapsulatus) |
PF00348(polyprenyl_synt) | 5 | ALA A 207LEU A 208LEU A 48LEU A 277ARG A 278 | None | 1.00A | 4wg0E-3m0gA:undetectable4wg0F-3m0gA:undetectable4wg0G-3m0gA:undetectable | 4wg0E-3m0gA:3.814wg0F-3m0gA:3.814wg0G-3m0gA:3.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oc7 | ENOYL-COA HYDRATASE (Mycobacteriumavium) |
PF00378(ECH_1) | 5 | ALA A 68LEU A 31GLU A 92LEU A 96LEU A 122 | None | 0.91A | 4wg0E-3oc7A:undetectable4wg0F-3oc7A:undetectable4wg0G-3oc7A:undetectable | 4wg0E-3oc7A:4.744wg0F-3oc7A:4.744wg0G-3oc7A:4.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pf0 | IMELYSIN-LIKEPROTEIN (Psychrobacterarcticus) |
PF09375(Peptidase_M75) | 5 | GLU A 181ALA A 184LEU A 183LEU A 178LEU A 171 | None | 1.00A | 4wg0E-3pf0A:undetectable4wg0F-3pf0A:undetectable4wg0G-3pf0A:undetectable | 4wg0E-3pf0A:5.914wg0F-3pf0A:5.914wg0G-3pf0A:5.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pih | UVRABC SYSTEMPROTEIN A (Thermotogamaritima) |
PF00005(ABC_tran) | 6 | GLU A 819ALA A 817LEU A 816LEU A 832LEU A 851LEU A 847 | None | 1.30A | 4wg0E-3pihA:undetectable4wg0F-3pihA:undetectable4wg0G-3pihA:undetectable | 4wg0E-3pihA:1.644wg0F-3pihA:1.644wg0G-3pihA:1.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pko | GERANYLGERANYLPYROPHOSPHATESYNTHASE (Lactobacillusbrevis) |
PF00348(polyprenyl_synt) | 5 | ALA A 290LEU A 289LEU A 164LEU A 245LEU A 246 | None | 1.00A | 4wg0E-3pkoA:undetectable4wg0F-3pkoA:undetectable4wg0G-3pkoA:undetectable | 4wg0E-3pkoA:2.994wg0F-3pkoA:2.994wg0G-3pkoA:2.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pwz | SHIKIMATEDEHYDROGENASE 3 (Pseudomonasputida) |
PF01488(Shikimate_DH)PF08501(Shikimate_dh_N) | 6 | GLU A 175ALA A 176LEU A 177LEU A 200LEU A 126LEU A 124 | None | 1.40A | 4wg0E-3pwzA:undetectable4wg0F-3pwzA:undetectable4wg0G-3pwzA:undetectable | 4wg0E-3pwzA:4.624wg0F-3pwzA:4.624wg0G-3pwzA:4.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q9v | DNA-BINDING RESPONSEREGULATOR (Deinococcusradiodurans) |
PF00486(Trans_reg_C) | 5 | ALA A 218LEU A 219LEU A 157LEU A 196LEU A 200 | None | 0.86A | 4wg0E-3q9vA:undetectable4wg0F-3q9vA:undetectable4wg0G-3q9vA:undetectable | 4wg0E-3q9vA:8.554wg0F-3q9vA:8.554wg0G-3q9vA:8.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s6k | ACETYLGLUTAMATEKINASE (Xanthomonascampestris) |
PF00696(AA_kinase)PF04768(NAT) | 6 | ALA A 132GLU A 125LYS A 122LEU A 123LEU A 57LEU A 60 | None | 1.40A | 4wg0E-3s6kA:undetectable4wg0F-3s6kA:undetectable4wg0G-3s6kA:undetectable | 4wg0E-3s6kA:3.334wg0F-3s6kA:3.334wg0G-3s6kA:3.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t58 | SULFHYDRYL OXIDASE 1 (Mus musculus) |
PF00085(Thioredoxin)PF04777(Evr1_Alr) | 6 | LEU A 86GLU A 205LEU A 153LEU A 97ARG A 94LEU A 99 | None | 1.49A | 4wg0E-3t58A:undetectable4wg0F-3t58A:undetectable4wg0G-3t58A:undetectable | 4wg0E-3t58A:4.854wg0F-3t58A:4.854wg0G-3t58A:4.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tma | METHYLTRANSFERASE (Thermusthermophilus) |
PF01170(UPF0020)PF02926(THUMP) | 5 | ALA A 295LEU A 296LEU A 304LEU A 308LEU A 281 | None | 0.95A | 4wg0E-3tmaA:undetectable4wg0F-3tmaA:undetectable4wg0G-3tmaA:undetectable | 4wg0E-3tmaA:4.204wg0F-3tmaA:4.204wg0G-3tmaA:4.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wkh | CELLOBIOSE2-EPIMERASE (Rhodothermusmarinus) |
PF07221(GlcNAc_2-epim) | 5 | TYR A 153GLU A 203LEU A 221ARG A 220LEU A 217 | None | 0.89A | 4wg0E-3wkhA:undetectable4wg0F-3wkhA:undetectable4wg0G-3wkhA:undetectable | 4wg0E-3wkhA:2.194wg0F-3wkhA:2.194wg0G-3wkhA:2.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a2p | RETINOIC ACIDINDUCIBLE PROTEIN I (Anasplatyrhynchos) |
PF00270(DEAD)PF00271(Helicase_C) | 5 | ALA A 622LEU A 619GLU A 614LEU A 615LEU A 633 | None | 0.93A | 4wg0E-4a2pA:undetectable4wg0F-4a2pA:undetectable4wg0G-4a2pA:undetectable | 4wg0E-4a2pA:2.344wg0F-4a2pA:2.344wg0G-4a2pA:2.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a2q | RETINOIC ACIDINDUCIBLE PROTEIN I (Anasplatyrhynchos) |
PF00270(DEAD)PF00271(Helicase_C)PF16739(CARD_2) | 5 | GLU A 5LYS A 6LEU A 9LEU A 61LEU A 57 | None | 0.97A | 4wg0E-4a2qA:undetectable4wg0F-4a2qA:undetectable4wg0G-4a2qA:undetectable | 4wg0E-4a2qA:1.634wg0F-4a2qA:1.634wg0G-4a2qA:1.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4atq | 4-AMINOBUTYRATETRANSAMINASE (Paenarthrobacteraurescens) |
PF00202(Aminotran_3) | 6 | GLU A 446ALA A 449LEU A 445LEU A 441LEU A 69LEU A 430 | None | 1.36A | 4wg0E-4atqA:undetectable4wg0F-4atqA:undetectable4wg0G-4atqA:undetectable | 4wg0E-4atqA:2.514wg0F-4atqA:2.514wg0G-4atqA:2.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bvu | PROTEIN KINASE OSPG (Shigellaflexneri) |
no annotation | 5 | LEU A 125TYR A 122GLU A 131LEU A 129LEU A 139 | None | 0.84A | 4wg0E-4bvuA:undetectable4wg0F-4bvuA:undetectable4wg0G-4bvuA:undetectable | 4wg0E-4bvuA:5.944wg0F-4bvuA:5.944wg0G-4bvuA:5.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bx9 | VACUOLAR PROTEINSORTING-ASSOCIATEDPROTEIN 33A (Homo sapiens) |
PF00995(Sec1) | 6 | ALA A 500LEU A 499GLU A 557LEU A 472ARG A 471LEU A 470 | None | 1.44A | 4wg0E-4bx9A:undetectable4wg0F-4bx9A:undetectable4wg0G-4bx9A:undetectable | 4wg0E-4bx9A:4.644wg0F-4bx9A:4.644wg0G-4bx9A:4.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fl3 | TYROSINE-PROTEINKINASE SYK (Homo sapiens) |
PF00017(SH2)PF07714(Pkinase_Tyr) | 5 | ALA A 204LEU A 205TYR A 216LEU A 255LEU A 251 | None | 0.99A | 4wg0E-4fl3A:undetectable4wg0F-4fl3A:undetectable4wg0G-4fl3A:undetectable | 4wg0E-4fl3A:2.774wg0F-4fl3A:2.774wg0G-4fl3A:2.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4he8 | NADH-QUINONEOXIDOREDUCTASESUBUNIT 8 (Thermusthermophilus) |
no annotation | 5 | GLU H 163LEU H 125LEU H 258LEU H 262LEU H 182 | None | 1.00A | 4wg0E-4he8H:undetectable4wg0F-4he8H:undetectable4wg0G-4he8H:undetectable | 4wg0E-4he8H:3.064wg0F-4he8H:3.064wg0G-4he8H:3.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i66 | UNCHARACTERIZEDPROTEIN HOCH_4089 (Haliangiumochraceum) |
PF13709(DUF4159) | 6 | GLU A 101ALA A 104LEU A 105LEU A 135LEU A 88LEU A 115 | None | 1.41A | 4wg0E-4i66A:undetectable4wg0F-4i66A:undetectable4wg0G-4i66A:undetectable | 4wg0E-4i66A:5.394wg0F-4i66A:5.394wg0G-4i66A:5.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i96 | RYANODINE RECEPTOR 1 (Oryctolaguscuniculus) |
PF01365(RYDR_ITPR)PF02815(MIR) | 5 | GLU A 263LEU A 262LEU A 220ARG A 221LEU A 222 | None | 0.99A | 4wg0E-4i96A:undetectable4wg0F-4i96A:undetectable4wg0G-4i96A:undetectable | 4wg0E-4i96A:4.744wg0F-4i96A:4.744wg0G-4i96A:4.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jci | PROLINE RACEMASE (Chromohalobactersalexigens) |
PF05544(Pro_racemase) | 5 | ALA A 181LEU A 182TYR A 185GLU A 175LEU A 174 | None | 0.98A | 4wg0E-4jciA:undetectable4wg0F-4jciA:undetectable4wg0G-4jciA:undetectable | 4wg0E-4jciA:4.714wg0F-4jciA:4.714wg0G-4jciA:4.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lls | GERANYLTRANSTRANSFERASE (Roseobacterdenitrificans) |
PF00348(polyprenyl_synt) | 5 | ALA A 207LEU A 208LEU A 47LEU A 277ARG A 278 | None | 0.81A | 4wg0E-4llsA:undetectable4wg0F-4llsA:undetectable4wg0G-4llsA:undetectable | 4wg0E-4llsA:4.654wg0F-4llsA:4.654wg0G-4llsA:4.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lry | PTS-DEPENDENTDIHYDROXYACETONEKINASE,DIHYDROXYACETONE-BINDING SUBUNIT DHAK (Escherichiacoli) |
PF02733(Dak1) | 5 | ALA A 351LEU A 352GLU A 157ASN A 283LEU A 281 | None | 0.97A | 4wg0E-4lryA:undetectable4wg0F-4lryA:undetectable4wg0G-4lryA:undetectable | 4wg0E-4lryA:7.804wg0F-4lryA:7.804wg0G-4lryA:7.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4myo | VIRGINIAMYCIN AACETYLTRANSFERASE (Staphylococcusaureus) |
PF00132(Hexapep) | 5 | GLU A 180ALA A 183LEU A 184GLU A 207LEU A 209 | None | 0.92A | 4wg0E-4myoA:undetectable4wg0F-4myoA:undetectable4wg0G-4myoA:undetectable | 4wg0E-4myoA:5.124wg0F-4myoA:5.124wg0G-4myoA:5.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nnq | PUTATIVE ENOYL-COAHYDRATASE (Streptomycesatroolivaceus) |
PF00378(ECH_1) | 5 | ALA A 125LEU A 122LEU A 33LEU A 38LEU A 41 | None | 0.98A | 4wg0E-4nnqA:undetectable4wg0F-4nnqA:undetectable4wg0G-4nnqA:undetectable | 4wg0E-4nnqA:3.864wg0F-4nnqA:3.864wg0G-4nnqA:3.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nuz | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE F2 (Streptococcuspyogenes) |
no annotation | 5 | ALA A 147LEU A 146LEU A 109ARG A 274LEU A 275 | None | 1.00A | 4wg0E-4nuzA:undetectable4wg0F-4nuzA:undetectable4wg0G-4nuzA:undetectable | 4wg0E-4nuzA:1.464wg0F-4nuzA:1.464wg0G-4nuzA:1.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o8s | PUTATIVE (Helicobacterpylori) |
PF08843(AbiEii) | 5 | ALA A 167LEU A 166TYR A 170ASN A 50LEU A 49 | None | 0.86A | 4wg0E-4o8sA:undetectable4wg0F-4o8sA:undetectable4wg0G-4o8sA:undetectable | 4wg0E-4o8sA:7.434wg0F-4o8sA:7.434wg0G-4o8sA:7.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ok0 | PUTATIVE (Helicobacterpylori) |
PF08843(AbiEii) | 5 | ALA A 167LEU A 166TYR A 170ASN A 50LEU A 49 | None | 0.90A | 4wg0E-4ok0A:undetectable4wg0F-4ok0A:undetectable4wg0G-4ok0A:undetectable | 4wg0E-4ok0A:6.344wg0F-4ok0A:6.344wg0G-4ok0A:6.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oo0 | MAF-LIKE PROTEINBCAL2394 (Burkholderiacenocepacia) |
PF02545(Maf) | 5 | LEU A 199GLU A 29LEU A 31LEU A 20LEU A 91 | None | 0.97A | 4wg0E-4oo0A:undetectable4wg0F-4oo0A:undetectable4wg0G-4oo0A:undetectable | 4wg0E-4oo0A:3.864wg0F-4oo0A:3.864wg0G-4oo0A:3.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q5h | PROTEIN KINASE OSPG (Shigella sonnei) |
no annotation | 5 | LEU A 125TYR A 122GLU A 131LEU A 129LEU A 139 | None | 0.81A | 4wg0E-4q5hA:undetectable4wg0F-4q5hA:undetectable4wg0G-4q5hA:undetectable | 4wg0E-4q5hA:7.884wg0F-4q5hA:7.884wg0G-4q5hA:7.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qmi | CYTOSKELETON-ASSOCIATED PROTEIN 5 (Homo sapiens) |
PF12348(CLASP_N) | 5 | LEU A 901LYS A 906LEU A 905ASN A 941LEU A 942 | None | 0.88A | 4wg0E-4qmiA:undetectable4wg0F-4qmiA:undetectable4wg0G-4qmiA:undetectable | 4wg0E-4qmiA:5.294wg0F-4qmiA:5.294wg0G-4qmiA:5.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ynq | THREE-PRIME REPAIREXONUCLEASE 1 (Mus musculus) |
no annotation | 6 | ALA A 105LEU A 108GLU A 137LEU A 34LEU A 69LEU A 67 | None | 1.48A | 4wg0E-4ynqA:undetectable4wg0F-4ynqA:undetectable4wg0G-4ynqA:undetectable | 4wg0E-4ynqA:6.704wg0F-4ynqA:6.704wg0G-4ynqA:6.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a0k | LABDANE-RELATEDDITERPENE SYNTHASE (Streptomycessp.) |
no annotation | 5 | LEU A 151TYR A 148LEU A 155LEU A 116LEU A 136 | None | 0.96A | 4wg0E-5a0kA:undetectable4wg0F-5a0kA:undetectable4wg0G-5a0kA:undetectable | 4wg0E-5a0kA:3.624wg0F-5a0kA:3.624wg0G-5a0kA:3.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a6b | N-ACETYL-BETA-D-GLUCOSAMINIDASE (Streptococcuspneumoniae) |
PF00728(Glyco_hydro_20) | 5 | GLU D 108ALA D 111LEU D 110LEU D 386LEU D 389 | None | 0.91A | 4wg0E-5a6bD:undetectable4wg0F-5a6bD:undetectable4wg0G-5a6bD:undetectable | 4wg0E-5a6bD:4.044wg0F-5a6bD:4.044wg0G-5a6bD:4.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5chc | DMSO REDUCTASEFAMILY TYPE IIENZYME,MOLYBDOPTERINSUBUNIT (Azospira oryzae) |
PF00384(Molybdopterin)PF01568(Molydop_binding) | 5 | ALA A 385LEU A 383GLU A 377LEU A 379LEU A 744 | None | 0.98A | 4wg0E-5chcA:undetectable4wg0F-5chcA:undetectable4wg0G-5chcA:undetectable | 4wg0E-5chcA:1.684wg0F-5chcA:1.684wg0G-5chcA:1.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dt5 | BETA-GLUCOSIDASE (Exiguobacteriumantarcticum) |
PF00232(Glyco_hydro_1) | 6 | ALA A 339LEU A 337TYR A 341LEU A 333ARG A 245LEU A 248 | None | 1.37A | 4wg0E-5dt5A:undetectable4wg0F-5dt5A:undetectable4wg0G-5dt5A:undetectable | 4wg0E-5dt5A:2.884wg0F-5dt5A:2.884wg0G-5dt5A:2.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ey0 | GTP-SENSINGTRANSCRIPTIONALPLEIOTROPICREPRESSOR CODY (Staphylococcusaureus) |
no annotation | 5 | ALA B 227LEU B 224GLU B 183LYS B 184LEU B 253 | None | 0.95A | 4wg0E-5ey0B:undetectable4wg0F-5ey0B:undetectable4wg0G-5ey0B:undetectable | 4wg0E-5ey0B:4.014wg0F-5ey0B:4.014wg0G-5ey0B:4.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f0l | VACUOLAR PROTEINSORTING-ASSOCIATEDPROTEIN 26A (Homo sapiens) |
PF03643(Vps26) | 5 | LEU B 149TYR B 40GLU B 146LEU B 132LEU B 18 | NoneGOL B 406 (-4.1A)NoneNoneNone | 0.70A | 4wg0E-5f0lB:undetectable4wg0F-5f0lB:undetectable4wg0G-5f0lB:undetectable | 4wg0E-5f0lB:6.324wg0F-5f0lB:6.324wg0G-5f0lB:6.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ghs | SSDNA-SPECIFICEXONUCLEASE (Thermococcuskodakarensis) |
PF02272(DHHA1) | 5 | ALA A 235LEU A 233LEU A 211LEU A 259LEU A 255 | None | 0.87A | 4wg0E-5ghsA:undetectable4wg0F-5ghsA:undetectable4wg0G-5ghsA:undetectable | 4wg0E-5ghsA:3.004wg0F-5ghsA:3.004wg0G-5ghsA:3.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h68 | CHROMOSOME PARTITIONPROTEIN SMC (Geobacillusstearothermophilus) |
PF02463(SMC_N) | 6 | GLU A1120ALA A1132LEU A1135TYR A1134LEU A1116LEU A1102 | None | 1.44A | 4wg0E-5h68A:undetectable4wg0F-5h68A:undetectable4wg0G-5h68A:undetectable | 4wg0E-5h68A:3.264wg0F-5h68A:3.264wg0G-5h68A:3.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hb1 | NUCLEOPORIN NUP170 (Chaetomiumthermophilum) |
PF03177(Nucleoporin_C) | 6 | ALA A 614LEU A 615LEU A 676ASN A 727LEU A 724LEU A 720 | None | 1.40A | 4wg0E-5hb1A:undetectable4wg0F-5hb1A:undetectable4wg0G-5hb1A:undetectable | 4wg0E-5hb1A:1.334wg0F-5hb1A:1.334wg0G-5hb1A:1.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hzk | INTERSECTIN-1,NPH1-1,INTERSECTIN-1 (Avena sativa;Homo sapiens) |
PF00621(RhoGEF)PF13426(PAS_9)PF16652(PH_13) | 5 | LEU B1245LEU B1462ASN B1292LEU B1295LEU B1299 | None | 0.92A | 4wg0E-5hzkB:undetectable4wg0F-5hzkB:undetectable4wg0G-5hzkB:undetectable | 4wg0E-5hzkB:2.914wg0F-5hzkB:2.914wg0G-5hzkB:2.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lox | PEPTIDASE (Pseudomonasaeruginosa) |
no annotation | 5 | TYR A 214LEU A 192LEU A 169ARG A 170LEU A 173 | None | 1.00A | 4wg0E-5loxA:undetectable4wg0F-5loxA:undetectable4wg0G-5loxA:undetectable | 4wg0E-5loxA:3.934wg0F-5loxA:3.934wg0G-5loxA:3.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lpc | VANADIUM-DEPENDENTBROMOPEROXIDASE (Acaryochlorismarina) |
no annotation | 5 | ALA A 461LEU A 463LEU A 440ARG A 164LEU A 170 | None | 0.97A | 4wg0E-5lpcA:undetectable4wg0F-5lpcA:undetectable4wg0G-5lpcA:undetectable | 4wg0E-5lpcA:3.854wg0F-5lpcA:3.854wg0G-5lpcA:3.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5msw | THIOESTER REDUCTASEDOMAIN-CONTAININGPROTEIN (Segniliparusrugosus) |
PF00501(AMP-binding)PF00550(PP-binding) | 5 | ALA A 71LEU A 70GLU A 101LEU A 102LEU A 326 | None | 0.92A | 4wg0E-5mswA:undetectable4wg0F-5mswA:undetectable4wg0G-5mswA:undetectable | 4wg0E-5mswA:1.104wg0F-5mswA:1.104wg0G-5mswA:1.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n94 | CG9323, ISOFORM A (Drosophilamelanogaster) |
no annotation | 5 | LEU A 259GLU A 286LEU A 290LEU A 277LEU A 275 | None U C 6 ( 4.9A)NoneNoneNone | 0.88A | 4wg0E-5n94A:undetectable4wg0F-5n94A:undetectable4wg0G-5n94A:undetectable | 4wg0E-5n94A:undetectable4wg0F-5n94A:undetectable4wg0G-5n94A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ojs | TRANSCRIPTION-ASSOCIATED PROTEIN 1 (Saccharomycescerevisiae) |
PF00454(PI3_PI4_kinase)PF02259(FAT) | 5 | ALA T3166LEU T3167LEU T3156LEU T3140LEU T3141 | None | 0.80A | 4wg0E-5ojsT:undetectable4wg0F-5ojsT:undetectable4wg0G-5ojsT:undetectable | 4wg0E-5ojsT:0.354wg0F-5ojsT:0.354wg0G-5ojsT:0.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5op0 | DNA POLYMERASE LIGD,POLYMERASE DOMAIN (Mycolicibacteriumsmegmatis) |
no annotation | 5 | ALA B 202LEU B 203LEU B 185LEU B 169LEU B 164 | None | 0.99A | 4wg0E-5op0B:undetectable4wg0F-5op0B:undetectable4wg0G-5op0B:undetectable | 4wg0E-5op0B:6.914wg0F-5op0B:6.914wg0G-5op0B:6.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ovt | BPH (Thiobacillusdenitrificans) |
no annotation | 5 | ALA A 59LEU A 58TYR A 61LEU A 88LEU A 84 | None | 0.94A | 4wg0E-5ovtA:undetectable4wg0F-5ovtA:undetectable4wg0G-5ovtA:undetectable | 4wg0E-5ovtA:undetectable4wg0F-5ovtA:undetectable4wg0G-5ovtA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zai | - (-) |
no annotation | 5 | GLU A 113LEU A 114LEU A 28LEU A 33LEU A 36 | None | 0.99A | 4wg0E-5zaiA:undetectable4wg0F-5zaiA:undetectable4wg0G-5zaiA:undetectable | 4wg0E-5zaiA:undetectable4wg0F-5zaiA:undetectable4wg0G-5zaiA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6elc | VARIANT SURFACEGLYCOPROTEIN (Trypanosomabrucei) |
no annotation | 5 | ALA A 289LEU A 286LEU A 281LEU A 45LEU A 179 | None | 0.98A | 4wg0E-6elcA:undetectable4wg0F-6elcA:undetectable4wg0G-6elcA:undetectable | 4wg0E-6elcA:undetectable4wg0F-6elcA:undetectable4wg0G-6elcA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ems | TRNA(GUANINE(9)-/ADENINE(9)-N1)-METHYLTRANSFERASE (Thermococcuskodakarensis) |
no annotation | 5 | GLU A 14LYS A 13LEU A 12LEU A 61LEU A 34 | None | 0.97A | 4wg0E-6emsA:undetectable4wg0F-6emsA:undetectable4wg0G-6emsA:undetectable | 4wg0E-6emsA:undetectable4wg0F-6emsA:undetectable4wg0G-6emsA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6en3 | ENDO-BETA-N-ACETYLGLUCOSAMINIDASEF2,MULTIFUNCTIONAL-AUTOPROCESSINGREPEATS-IN-TOXIN (Vibriocholerae;Streptococcuspyogenes) |
no annotation | 5 | ALA A 147LEU A 146LEU A 109ARG A 274LEU A 275 | None | 0.88A | 4wg0E-6en3A:undetectable4wg0F-6en3A:undetectable4wg0G-6en3A:undetectable | 4wg0E-6en3A:undetectable4wg0F-6en3A:undetectable4wg0G-6en3A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6en4 | SPLICING FACTOR 3BSUBUNIT 1 (Homo sapiens) |
no annotation | 5 | TYR C 979LEU C1038LEU C1020ARG C1019LEU C1016 | None | 0.99A | 4wg0E-6en4C:undetectable4wg0F-6en4C:undetectable4wg0G-6en4C:undetectable | 4wg0E-6en4C:undetectable4wg0F-6en4C:undetectable4wg0G-6en4C:undetectable |