SIMILAR PATTERNS OF AMINO ACIDS FOR 4WCX_C_SAMC503_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ais | PROTEIN(TRANSCRIPTIONINITIATION FACTORIIB) (Pyrococcuswoesei) |
PF00382(TFIIB) | 5 | TYR B1190GLY B1187GLU B1185LEU B1125ALA B1162 | None | 1.23A | 4wcxC-1aisB:undetectable | 4wcxC-1aisB:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b3n | PROTEIN (KETOACYLACYL CARRIER PROTEINSYNTHASE 2) (Escherichiacoli) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 343LEU A 407ARG A 175ALA A 173HIS A 172 | None | 1.23A | 4wcxC-1b3nA:undetectable | 4wcxC-1b3nA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b65 | PROTEIN(AMINOPEPTIDASE) (Ochrobactrumanthropi) |
PF03576(Peptidase_S58) | 5 | GLY A 205LEU A 261LEU A 269ARG A 272ALA A 327 | None | 1.21A | 4wcxC-1b65A:undetectable | 4wcxC-1b65A:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c3r | HDLP (HISTONEDEACETYLASE-LIKEPROTEIN) (Aquifexaeolicus) |
PF00850(Hist_deacetyl) | 5 | GLU A 284PHE A 275LEU A 270PRO A 259LEU A 226 | None | 1.05A | 4wcxC-1c3rA:undetectable | 4wcxC-1c3rA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c3r | HDLP (HISTONEDEACETYLASE-LIKEPROTEIN) (Aquifexaeolicus) |
PF00850(Hist_deacetyl) | 5 | PHE A 275LEU A 270PRO A 259LEU A 226ALA A 234 | None | 1.12A | 4wcxC-1c3rA:undetectable | 4wcxC-1c3rA:22.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i1q | ANTHRANILATESYNTHASE COMPONENT I (Salmonellaenterica) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 5 | TYR A 176GLY A 148LEU A 130LEU A 80ALA A 58 | None | 1.01A | 4wcxC-1i1qA:undetectable | 4wcxC-1i1qA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ir6 | EXONUCLEASE RECJ (Thermusthermophilus) |
PF01368(DHH)PF02272(DHHA1) | 5 | GLY A 170GLU A 144LEU A 194LEU A 198ALA A 63 | None | 1.20A | 4wcxC-1ir6A:undetectable | 4wcxC-1ir6A:22.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1of3 | BETA-MANNOSIDASE (Thermotogamaritima) |
PF09212(CBM27) | 5 | TYR A 83GLY A 44LEU A 78ARG A 135HIS A 133 | None CA A1174 (-4.2A)NoneNoneNone | 1.12A | 4wcxC-1of3A:undetectable | 4wcxC-1of3A:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ofe | FERREDOXIN-DEPENDENTGLUTAMATE SYNTHASE 2 (Synechocystissp. PCC 6803) |
PF00310(GATase_2)PF01493(GXGXG)PF01645(Glu_synthase)PF04898(Glu_syn_central) | 6 | GLY A1083GLU A1086LEU A1219LEU A 845ARG A1206ALA A 841 | None | 1.49A | 4wcxC-1ofeA:7.8 | 4wcxC-1ofeA:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1og3 | T-CELLECTO-ADP-RIBOSYLTRANSFERASE 2 (Rattusnorvegicus) |
PF01129(ART) | 5 | GLU A 196LEU A 116PRO A 64ALA A 74HIS A 71 | None | 1.20A | 4wcxC-1og3A:undetectable | 4wcxC-1og3A:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qor | QUINONEOXIDOREDUCTASE (Escherichiacoli) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | TYR A 95GLU A 312GLY A 12LEU A 304ALA A 18 | None | 1.27A | 4wcxC-1qorA:2.4 | 4wcxC-1qorA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qor | QUINONEOXIDOREDUCTASE (Escherichiacoli) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | TYR A 95GLU A 312LEU A 325LEU A 304ALA A 18 | None | 1.24A | 4wcxC-1qorA:2.4 | 4wcxC-1qorA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rbl | RIBULOSE 1,5BISPHOSPHATECARBOXYLASE/OXYGENASE (LARGE CHAIN) (Synechococcuselongatus) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 5 | TYR A 239GLU A 158GLY A 237PRO A 152LEU A 280 | None | 1.18A | 4wcxC-1rblA:2.9 | 4wcxC-1rblA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rvk | ISOMERASE/LACTONIZING ENZYME (Agrobacteriumfabrum) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | TYR A 328GLY A 282GLU A 258ALA A 320HIS A 317 | NoneNone MG A 999 (-2.5A)NoneNone | 1.12A | 4wcxC-1rvkA:10.9 | 4wcxC-1rvkA:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1svd | RIBULOSE-1,5-BISPHOSPHATECARBOXYLASE/OXYGENASE LARGE SUBUNIT (Halothiobacillusneapolitanus) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 5 | TYR A 232GLU A 151GLY A 230PRO A 145LEU A 273 | None | 1.24A | 4wcxC-1svdA:8.2 | 4wcxC-1svdA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t2w | SORTASE (Staphylococcusaureus) |
PF04203(Sortase) | 5 | TYR A 187GLY A 90GLU A 106ALA A 184HIS A 120 | NoneNoneNoneTHR A 334 ( 4.6A)None | 1.12A | 4wcxC-1t2wA:undetectable | 4wcxC-1t2wA:17.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v19 | 2-KETO-3-DEOXYGLUCONATE KINASE (Thermusthermophilus) |
PF00294(PfkB) | 5 | GLY A 290GLU A 289LEU A 43LEU A 258ALA A 274 | None | 1.19A | 4wcxC-1v19A:3.1 | 4wcxC-1v19A:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x55 | ASPARAGINYL-TRNASYNTHETASE (Pyrococcushorikoshii) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 5 | GLU A 309GLY A 354GLU A 353LEU A 221HIS A 220 | NoneNoneNoneNSS A3002 (-4.7A)PO4 A3001 ( 4.1A) | 0.99A | 4wcxC-1x55A:undetectable | 4wcxC-1x55A:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ytk | NICOTINATEPHOSPHORIBOSYLTRANSFERASE FROMTHERMOPLASMAACIDOPHILUM (Thermoplasmaacidophilum) |
PF01729(QRPTase_C) | 5 | GLU A 345PRO A 91LEU A 88ARG A 83ALA A 85 | None | 1.25A | 4wcxC-1ytkA:5.0 | 4wcxC-1ytkA:22.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ag1 | BENZALDEHYDE LYASE (Pseudomonasfluorescens) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | GLY A 24GLU A 50LEU A 461LEU A 468ALA A 431 | None | 1.13A | 4wcxC-2ag1A:undetectable | 4wcxC-2ag1A:21.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cw5 | BACTERIALFLUORINATING ENZYMEHOMOLOG (Thermusthermophilus) |
PF01887(SAM_adeno_trans) | 5 | GLY A 214GLU A 215LEU A 246ARG A 241ALA A 243 | None | 1.08A | 4wcxC-2cw5A:undetectable | 4wcxC-2cw5A:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cx7 | STEROL CARRIERPROTEIN 2 (Thermusthermophilus) |
PF02036(SCP2) | 5 | GLY A 89GLU A 85LEU A 35LEU A 33ALA A 119 | None | 1.16A | 4wcxC-2cx7A:undetectable | 4wcxC-2cx7A:13.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ecf | DIPEPTIDYL PEPTIDASEIV (Stenotrophomonasmaltophilia) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 5 | TYR A 614TYR A 661GLY A 660GLU A 663PRO A 527 | None | 1.17A | 4wcxC-2ecfA:undetectable | 4wcxC-2ecfA:19.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hy5 | PUTATIVESULFURTRANSFERASEDSRE (Allochromatiumvinosum) |
PF02635(DrsE) | 5 | TYR A 40GLY A 86LEU A 112LEU A 115ARG A 36 | None | 1.12A | 4wcxC-2hy5A:2.1 | 4wcxC-2hy5A:14.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2izo | FLAPSTRUCTURE-SPECIFICENDONUCLEASE (Sulfolobussolfataricus) |
PF00752(XPG_N)PF00867(XPG_I) | 5 | PHE A 13LEU A 11PRO A 204LEU A 206ALA A 165 | None | 0.95A | 4wcxC-2izoA:undetectable | 4wcxC-2izoA:23.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j4g | HYALURONOGLUCOSAMINIDASE (Bacteroidesthetaiotaomicron) |
PF02838(Glyco_hydro_20b)PF07555(NAGidase) | 5 | TYR A 81GLY A 99GLU A 61LEU A 44LEU A 111 | None | 1.20A | 4wcxC-2j4gA:5.0 | 4wcxC-2j4gA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j86 | PROTEINSERINE-THREONINEPHOSPHATASE (Synechococcuselongatus) |
PF13672(PP2C_2) | 5 | TYR A 123GLY A 194GLU A 197LEU A 130ARG A 187 | NoneNone MG A1241 ( 4.6A)NoneNone | 1.00A | 4wcxC-2j86A:undetectable | 4wcxC-2j86A:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jar | 5'(3')-DEOXYRIBONUCLEOTIDASE (Mus musculus) |
PF06941(NT5C) | 5 | TYR A 115GLY A 112GLU A 113LEU A 17LEU A 86 | None | 1.23A | 4wcxC-2jarA:undetectable | 4wcxC-2jarA:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kii | PUTATIVEUNCHARACTERIZEDPROTEIN (Shewanellaoneidensis) |
PF07700(HNOB) | 5 | TYR A 36GLU A 46PHE A 69LEU A 73LEU A 77 | NoneNoneNoneNoneHEM A 182 ( 2.9A) | 1.22A | 4wcxC-2kiiA:undetectable | 4wcxC-2kiiA:16.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2m56 | CAMPHOR5-MONOOXYGENASE (Pseudomonasputida) |
PF00067(p450) | 5 | GLU A 366GLY A 359LEU A 250LEU A 177ALA A 167 | NoneHEM A 501 ( 3.9A)NoneNoneNone | 1.18A | 4wcxC-2m56A:undetectable | 4wcxC-2m56A:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o7r | CXE CARBOXYLESTERASE (Actinidiaeriantha) |
PF07859(Abhydrolase_3) | 5 | GLY A 203GLU A 201PHE A 89ARG A 125ALA A 127 | 4PA A 369 ( 3.7A)NoneNoneNoneNone | 1.19A | 4wcxC-2o7rA:2.1 | 4wcxC-2o7rA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oxf | URIDINEPHOSPHORYLASE (Salmonellaenterica) |
PF01048(PNP_UDP_1) | 5 | GLY A1068LEU A1011LEU A1016ARG A1054ALA A1022 | None | 1.17A | 4wcxC-2oxfA:undetectable | 4wcxC-2oxfA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p91 | ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE[NADH] (Aquifexaeolicus) |
PF13561(adh_short_C2) | 5 | GLU A 84LEU A 148LEU A 100ARG A 23ALA A 51 | None | 1.04A | 4wcxC-2p91A:2.3 | 4wcxC-2p91A:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rfm | PUTATIVE ANKYRINREPEAT PROTEINTV1425 (Thermoplasmavolcanium) |
PF12796(Ank_2)PF13857(Ank_5) | 5 | GLY A 131GLU A 130LEU A 102LEU A 118ALA A 155 | None | 1.25A | 4wcxC-2rfmA:undetectable | 4wcxC-2rfmA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rjb | UNCHARACTERIZEDPROTEIN (Shigellaflexneri) |
PF07063(DUF1338) | 5 | GLU A 271GLU A 25PHE A 288ALA A 212HIS A 205 | None | 1.14A | 4wcxC-2rjbA:undetectable | 4wcxC-2rjbA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rjb | UNCHARACTERIZEDPROTEIN (Shigellaflexneri) |
PF07063(DUF1338) | 5 | GLU A 271GLU A 25PHE A 288LEU A 210HIS A 205 | None | 1.08A | 4wcxC-2rjbA:undetectable | 4wcxC-2rjbA:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vqa | SLL1358 PROTEIN (Synechocystissp. PCC 6803) |
PF00190(Cupin_1) | 5 | GLY A 171GLU A 170PRO A 203LEU A 180HIS A 182 | None MN A1005 ( 4.9A)NoneNoneNone | 1.15A | 4wcxC-2vqaA:undetectable | 4wcxC-2vqaA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w3p | BENZOYL-COA-DIHYDRODIOL LYASE (Paraburkholderiaxenovorans) |
PF00378(ECH_1) | 5 | TYR A 48GLY A 47LEU A 540LEU A 172ALA A 94 | NoneNoneNoneNoneBME A 601 ( 4.5A) | 1.25A | 4wcxC-2w3pA:undetectable | 4wcxC-2w3pA:22.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ww8 | CELL WALL SURFACEANCHOR FAMILYPROTEIN (Streptococcuspneumoniae) |
PF13519(VWA_2) | 5 | GLU A 181GLY A 187GLU A 186LEU A 623ALA A 625 | EPE A1101 (-3.2A)NoneNoneNoneNone | 1.27A | 4wcxC-2ww8A:undetectable | 4wcxC-2ww8A:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yx0 | RADICAL SAM ENZYME (Pyrococcushorikoshii) |
PF04055(Radical_SAM)PF08608(Wyosine_form) | 5 | GLU A 152PHE A 228LEU A 229LEU A 260ALA A 204 | None | 1.03A | 4wcxC-2yx0A:10.6 | 4wcxC-2yx0A:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yyl | 4-HYDROXYPHENYLACETATE-3-HYDROXYLASE (Thermusthermophilus) |
PF03241(HpaB)PF11794(HpaB_N) | 5 | GLY A 276LEU A 351PRO A 74ALA A 339HIS A 286 | None | 1.25A | 4wcxC-2yylA:2.3 | 4wcxC-2yylA:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zuy | YESX PROTEIN (Bacillussubtilis) |
PF01839(FG-GAP) | 5 | GLY A 240GLU A 241PHE A 166LEU A 546ALA A 121 | None | 1.27A | 4wcxC-2zuyA:undetectable | 4wcxC-2zuyA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aqp | PROBABLE SECDFPROTEIN-EXPORTMEMBRANE PROTEIN (Thermusthermophilus) |
PF02355(SecD_SecF)PF07549(Sec_GG) | 5 | GLY A 708LEU A 333LEU A 403ALA A 384HIS A 381 | None | 1.04A | 4wcxC-3aqpA:undetectable | 4wcxC-3aqpA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d2l | SAM-DEPENDENTMETHYLTRANSFERASE (Exiguobacteriumsibiricum) |
PF13649(Methyltransf_25) | 5 | TYR A 54GLU A 31GLY A 33LEU A 126LEU A 132 | None | 1.24A | 4wcxC-3d2lA:2.2 | 4wcxC-3d2lA:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e2v | 3'-5'-EXONUCLEASE (Saccharomycescerevisiae) |
PF01026(TatD_DNase) | 5 | GLU A 387GLU A 332PHE A 357LEU A 68ALA A 79 | NoneGOL A 426 (-2.9A)NoneNoneNone | 0.97A | 4wcxC-3e2vA:8.2 | 4wcxC-3e2vA:21.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eq2 | PROBABLETWO-COMPONENTRESPONSE REGULATOR (Pseudomonasaeruginosa) |
PF00072(Response_reg)PF07228(SpoIIE) | 5 | GLU A 178GLY A 176GLU A 175LEU A 331LEU A 294 | None | 1.25A | 4wcxC-3eq2A:3.4 | 4wcxC-3eq2A:23.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ff6 | ACETYL-COACARBOXYLASE 2 (Homo sapiens) |
PF01039(Carboxyl_trans) | 5 | TYR A2192GLY A2226LEU A2317LEU A2326ARG A2329 | None | 1.24A | 4wcxC-3ff6A:2.4 | 4wcxC-3ff6A:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hmj | FATTY ACID SYNTHASESUBUNIT ALPHA (Saccharomycescerevisiae) |
PF00109(ketoacyl-synt)PF01648(ACPS)PF02801(Ketoacyl-synt_C) | 5 | TYR A1332GLY A1383PHE A1223LEU A1291LEU A1290 | None | 1.26A | 4wcxC-3hmjA:2.5 | 4wcxC-3hmjA:13.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l5h | INTERLEUKIN-6RECEPTOR SUBUNITBETA (Homo sapiens) |
PF00041(fn3)PF06328(Lep_receptor_Ig)PF09240(IL6Ra-bind) | 5 | TYR A 470GLY A 527LEU A 464LEU A 460ALA A 410 | None | 1.17A | 4wcxC-3l5hA:undetectable | 4wcxC-3l5hA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l5j | INTERLEUKIN-6RECEPTOR SUBUNITBETA (Homo sapiens) |
PF00041(fn3) | 5 | TYR A 470GLY A 527LEU A 464LEU A 460ALA A 410 | None | 1.14A | 4wcxC-3l5jA:undetectable | 4wcxC-3l5jA:21.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n2x | UNCHARACTERIZEDPROTEIN YAGE (Escherichiacoli) |
PF00701(DHDPS) | 5 | GLY A 57GLU A 59LEU A 299LEU A 303ALA A 226 | MCL A 174 ( 3.6A)NoneNoneNoneNone | 1.09A | 4wcxC-3n2xA:5.8 | 4wcxC-3n2xA:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p4s | FUMARATE REDUCTASEFLAVOPROTEIN SUBUNIT (Escherichiacoli) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 5 | TYR A 199GLY A 196LEU A 512LEU A 482ALA A 458 | None | 1.04A | 4wcxC-3p4sA:4.9 | 4wcxC-3p4sA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q87 | N6 ADENINE SPECIFICDNA METHYLASE (Encephalitozooncuniculi) |
PF05175(MTS) | 5 | TYR B 141GLY B 161LEU B 30LEU B 70ALA B 113 | NoneNoneNoneSAM B 300 (-4.4A)None | 1.24A | 4wcxC-3q87B:2.7 | 4wcxC-3q87B:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ruy | ORNITHINEAMINOTRANSFERASE (Bacillusanthracis) |
PF00202(Aminotran_3) | 5 | TYR A 88GLY A 85LEU A 257LEU A 253ALA A 268 | None | 1.08A | 4wcxC-3ruyA:undetectable | 4wcxC-3ruyA:23.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u0b | OXIDOREDUCTASE,SHORT CHAINDEHYDROGENASE/REDUCTASE FAMILY PROTEIN (Mycolicibacteriumsmegmatis) |
PF13561(adh_short_C2) | 5 | TYR A 64LEU A 44LEU A 66ARG A 57ALA A 59 | NoneNone NA A 451 ( 4.9A)NoneNone | 1.11A | 4wcxC-3u0bA:undetectable | 4wcxC-3u0bA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u5r | UNCHARACTERIZEDPROTEIN (Sinorhizobiummeliloti) |
PF00578(AhpC-TSA) | 5 | TYR E 123GLU E 79GLY E 122LEU E 178ALA E 65 | None | 0.96A | 4wcxC-3u5rE:undetectable | 4wcxC-3u5rE:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vw5 | CELLOBIOSE2-EPIMERASE (Ruminococcusalbus) |
PF07221(GlcNAc_2-epim) | 5 | GLU A 78GLY A 28LEU A 119LEU A 138ARG A 137 | None | 1.04A | 4wcxC-3vw5A:2.2 | 4wcxC-3vw5A:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w04 | DWARF 88 ESTERASE (Oryza sativa) |
PF12697(Abhydrolase_6) | 5 | GLY A 171PHE A 143LEU A 100ALA A 84HIS A 76 | None | 1.22A | 4wcxC-3w04A:undetectable | 4wcxC-3w04A:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aj9 | CATALASE-3 (Neurosporacrassa) |
PF00199(Catalase)PF06628(Catalase-rel) | 5 | TYR A 240GLY A 235PHE A 291LEU A 296HIS A 242 | None | 1.27A | 4wcxC-4aj9A:3.0 | 4wcxC-4aj9A:21.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4amc | GLUCANSUCRASE (Lactobacillusreuteri) |
PF01473(CW_binding_1)PF02324(Glyco_hydro_70) | 5 | TYR A1322GLY A1327LEU A1346LEU A1341ALA A1371 | None | 1.27A | 4wcxC-4amcA:4.4 | 4wcxC-4amcA:18.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e8o | AAC(6')-IH PROTEIN (Acinetobacterbaumannii) |
PF00583(Acetyltransf_1) | 5 | GLY A 131LEU A 58LEU A 43ARG A 42ALA A 76 | None | 1.24A | 4wcxC-4e8oA:undetectable | 4wcxC-4e8oA:16.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g2t | SSFS6 (Streptomycessp. SF2575) |
PF00201(UDPGT)PF06722(DUF1205) | 5 | GLU A 115GLY A 12GLU A 11LEU A 63ALA A 315 | NoneTYD A 401 ( 3.7A)NoneNoneNone | 1.10A | 4wcxC-4g2tA:undetectable | 4wcxC-4g2tA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gyi | RIO2 KINASE (Chaetomiumthermophilum) |
PF01163(RIO1)PF09202(Rio2_N) | 5 | GLY A 105LEU A 123ARG A 184ALA A 159HIS A 185 | ADP A 401 ( 4.8A)NoneNoneNoneEDO A 403 (-4.1A) | 1.27A | 4wcxC-4gyiA:undetectable | 4wcxC-4gyiA:23.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hvf | GREEN FLUORESCENTPROTEIN BLFP-Y6 (Branchiostomalanceolatum) |
PF01353(GFP) | 5 | TYR A 64TYR A 105GLY A 114GLU A 8PHE A 209 | NoneCR2 A 58 ( 4.5A)NoneNoneCR2 A 58 ( 4.5A) | 1.24A | 4wcxC-4hvfA:undetectable | 4wcxC-4hvfA:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hvf | GREEN FLUORESCENTPROTEIN BLFP-Y6 (Branchiostomalanceolatum) |
PF01353(GFP) | 5 | TYR A 105GLY A 114GLU A 8PRO A 30ALA A 78 | CR2 A 58 ( 4.5A)NoneNoneNoneNone | 1.24A | 4wcxC-4hvfA:undetectable | 4wcxC-4hvfA:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m4d | LIPOPOLYSACCHARIDE-BINDING PROTEIN (Mus musculus) |
PF01273(LBP_BPI_CETP)PF02886(LBP_BPI_CETP_C) | 5 | TYR A 212LEU A 144PRO A 236LEU A 101ALA A 42 | PC1 A 506 (-3.7A)NoneNoneNonePC1 A 506 (-3.6A) | 1.20A | 4wcxC-4m4dA:undetectable | 4wcxC-4m4dA:21.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mkv | RIBULOSEBISPHOSPHATECARBOXYLASE LARGECHAIN (Pisum sativum) |
PF00016(RuBisCO_large)PF02788(RuBisCO_large_N) | 5 | TYR A 239GLU A 158GLY A 237PRO A 152LEU A 280 | None | 1.19A | 4wcxC-4mkvA:4.7 | 4wcxC-4mkvA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n9w | GDP-MANNOSE-DEPENDENTALPHA-(1-2)-PHOSPHATIDYLINOSITOLMANNOSYLTRANSFERASE (Mycolicibacteriumsmegmatis) |
PF13439(Glyco_transf_4)PF13692(Glyco_trans_1_4) | 5 | GLY A 249GLU A 231LEU A 207PRO A 269ALA A 263 | None | 1.25A | 4wcxC-4n9wA:2.4 | 4wcxC-4n9wA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nq3 | CYANURIC ACIDAMIDOHYDROLASE (Azorhizobiumcaulinodans) |
PF09663(Amido_AtzD_TrzD) | 5 | GLY A 273LEU A 107LEU A 239ALA A 348HIS A 151 | None | 1.21A | 4wcxC-4nq3A:undetectable | 4wcxC-4nq3A:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oa7 | TANKYRASE-1 (Homo sapiens) |
PF00644(PARP) | 5 | TYR A1213GLY A1211GLU A1199LEU A1256ALA A1215 | 2XS A1402 (-4.2A)NoneNoneNoneNone | 1.09A | 4wcxC-4oa7A:undetectable | 4wcxC-4oa7A:16.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oe7 | PROBABLE2-KETO-3-DEOXY-GALACTONATE ALDOLASE YAGE (Escherichiacoli) |
PF00701(DHDPS) | 5 | GLY A 57GLU A 59LEU A 299LEU A 303ALA A 226 | PYR A 410 ( 3.4A)NoneNoneNoneNone | 1.08A | 4wcxC-4oe7A:12.3 | 4wcxC-4oe7A:23.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pdy | AMINOGLYCOSIDEPHOSPHOTRANSFERASE (Alicyclobacillusacidocaldarius) |
PF01636(APH) | 5 | PHE A 134LEU A 131LEU A 259ARG A 262ALA A 116 | None | 1.06A | 4wcxC-4pdyA:undetectable | 4wcxC-4pdyA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pe2 | MALTOSE ABCTRANSPORTERPERIPLASMICPROTEIN,PREPILIN-TYPE N-TERMINALCLEAVAGE/METHYLATIONDOMAIN PROTEIN (Escherichiacoli;Clostridioidesdifficile) |
PF13416(SBP_bac_8) | 5 | TYR A 307GLY A 19GLU A 22LEU A 311ALA A 109 | None | 1.26A | 4wcxC-4pe2A:undetectable | 4wcxC-4pe2A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qgo | DNA-ENTRY NUCLEASE(COMPETENCE-SPECIFICNUCLEASE) (Streptococcusagalactiae) |
PF01223(Endonuclease_NS) | 5 | TYR A 192GLY A 188LEU A 154LEU A 106ALA A 229 | None | 1.11A | 4wcxC-4qgoA:undetectable | 4wcxC-4qgoA:19.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r33 | NOSL (Streptomycesactuosus) |
PF06968(BATS) | 6 | GLY A 142GLU A 143PHE A 202LEU A 250PRO A 283ALA A 288 | SAH A 501 (-3.6A)NoneSAH A 501 ( 4.6A)SAH A 501 ( 3.6A)NoneSAH A 501 ( 3.7A) | 0.60A | 4wcxC-4r33A:38.0 | 4wcxC-4r33A:29.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r8e | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 2 (Yersinia pestis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 343LEU A 407ARG A 175ALA A 173HIS A 172 | None | 1.27A | 4wcxC-4r8eA:undetectable | 4wcxC-4r8eA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r9o | PUTATIVE ALDO/KETOREDUCTASE (Salmonellaenterica) |
PF00248(Aldo_ket_red) | 5 | GLU A 267LEU A 42LEU A 74ARG A 75ALA A 67 | None | 1.23A | 4wcxC-4r9oA:6.2 | 4wcxC-4r9oA:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r9o | PUTATIVE ALDO/KETOREDUCTASE (Salmonellaenterica) |
PF00248(Aldo_ket_red) | 5 | GLY A 264LEU A 42LEU A 74ARG A 75ALA A 67 | None | 1.07A | 4wcxC-4r9oA:6.2 | 4wcxC-4r9oA:19.38 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4rtb | HYDG PROTEIN (Carboxydothermushydrogenoformans) |
PF04055(Radical_SAM)PF06968(BATS) | 8 | TYR A 94GLY A 134GLU A 135PHE A 187LEU A 231PRO A 265LEU A 267ALA A 270 | SAM A 501 (-4.5A)SF4 A 502 ( 3.9A)NoneSAM A 501 (-4.3A)SAM A 501 (-4.1A)NoneSAM A 501 (-4.4A)SAM A 501 ( 3.7A) | 0.39A | 4wcxC-4rtbA:46.2 | 4wcxC-4rtbA:43.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rvs | PROBABLE QUINONEREDUCTASE QOR(NADPH:QUINONEREDUCTASE)(ZETA-CRYSTALLINHOMOLOG PROTEIN) (Mycobacteriumtuberculosis) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 292GLU A 294LEU A 166ALA A 130HIS A 131 | None | 1.22A | 4wcxC-4rvsA:undetectable | 4wcxC-4rvsA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rvs | PROBABLE QUINONEREDUCTASE QOR(NADPH:QUINONEREDUCTASE)(ZETA-CRYSTALLINHOMOLOG PROTEIN) (Mycobacteriumtuberculosis) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 292GLU A 294LEU A 166LEU A 134HIS A 131 | None | 1.21A | 4wcxC-4rvsA:undetectable | 4wcxC-4rvsA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4um2 | TELOMERASE-BINDINGPROTEIN EST1A (Homo sapiens) |
PF10373(EST1_DNA_bind)PF10374(EST1) | 5 | TYR A 787GLY A 766PHE A 948LEU A 783ALA A 776 | None | 1.20A | 4wcxC-4um2A:4.2 | 4wcxC-4um2A:23.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4wcx | BIOTIN AND THIAMINSYNTHESIS ASSOCIATED (Thermoanaerobacteritalicus) |
PF04055(Radical_SAM)PF06968(BATS) | 11 | TYR A 96TYR A 99GLU A 133GLY A 135GLU A 136PHE A 192LEU A 236PRO A 270LEU A 272ARG A 273ALA A 275 | NoneMET A 503 (-3.4A)MET A 503 (-3.2A)MET A 503 ( 3.6A)NoneNoneNoneNoneNoneNoneNone | 0.75A | 4wcxC-4wcxA:61.5 | 4wcxC-4wcxA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a55 | ENDO-ALPHA-N-ACETYLGALACTOSAMINIDASE (Streptococcuspneumoniae) |
PF12905(Glyco_hydro_101)PF17451(Glyco_hyd_101C) | 5 | GLY A1200GLU A1202LEU A1093LEU A1069ALA A1078 | EDO A2423 ( 3.7A)NoneNoneNoneNone | 1.25A | 4wcxC-5a55A:4.2 | 4wcxC-5a55A:18.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b3g | PROTEIN SHORT-ROOT (Arabidopsisthaliana) |
PF03514(GRAS) | 5 | GLU B 485LEU B 276PRO B 284LEU B 286ALA B 354 | None | 0.98A | 4wcxC-5b3gB:2.6 | 4wcxC-5b3gB:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b3h | PROTEIN SHORT-ROOT (Arabidopsisthaliana) |
PF03514(GRAS) | 5 | GLU B 485LEU B 276PRO B 284LEU B 286ALA B 354 | None | 1.07A | 4wcxC-5b3hB:2.6 | 4wcxC-5b3hB:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hb4 | NUP192,NUCLEOPORINNUP192 (Chaetomiumthermophilum) |
PF11894(Nup192) | 5 | TYR B1424LEU B1420LEU B1423ARG B1366ALA B1368 | None | 1.23A | 4wcxC-5hb4B:2.2 | 4wcxC-5hb4B:14.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jq9 | DIHYDROPTEROATESYNTHASE (Yersinia pestis) |
PF00809(Pterin_bind) | 5 | GLY A 59GLU A 73ARG A 46ALA A 44HIS A 43 | NoneNoneEDO A 302 ( 4.3A)NoneEDO A 302 ( 4.8A) | 1.13A | 4wcxC-5jq9A:13.5 | 4wcxC-5jq9A:20.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k8o | 5-NITROANTHRANILICACID AMINOHYDROLASE (Bradyrhizobiumsp.) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | TYR A 388GLY A 389GLU A 196LEU A 81LEU A 420 | NoneNone MN A 501 ( 1.8A)NoneNone | 1.25A | 4wcxC-5k8oA:2.2 | 4wcxC-5k8oA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l9w | ACETOPHENONECARBOXYLASE DELTASUBUNIT (Aromatoleumaromaticum) |
PF02538(Hydantoinase_B) | 5 | GLU A 301GLY A 299LEU A 6ALA A 312HIS A 309 | None | 1.16A | 4wcxC-5l9wA:undetectable | 4wcxC-5l9wA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ltq | GREEN FLUORESCENTPROTEIN BLFP-Y3 (Branchiostomalanceolatum) |
PF01353(GFP) | 5 | TYR A 64TYR A 104GLY A 113GLU A 8HIS A 62 | NoneCR2 A 59 ( 4.6A)NoneNoneCR2 A 59 (-4.1A) | 1.02A | 4wcxC-5ltqA:undetectable | 4wcxC-5ltqA:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ltq | GREEN FLUORESCENTPROTEIN BLFP-Y3 (Branchiostomalanceolatum) |
PF01353(GFP) | 5 | TYR A 64TYR A 104GLY A 113PHE A 208HIS A 62 | NoneCR2 A 59 ( 4.6A)NoneCR2 A 59 ( 4.6A)CR2 A 59 (-4.1A) | 1.06A | 4wcxC-5ltqA:undetectable | 4wcxC-5ltqA:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ltq | GREEN FLUORESCENTPROTEIN BLFP-Y3 (Branchiostomalanceolatum) |
PF01353(GFP) | 5 | TYR A 104GLY A 113GLU A 8PRO A 30ALA A 77 | CR2 A 59 ( 4.6A)NoneNoneNoneNone | 1.21A | 4wcxC-5ltqA:undetectable | 4wcxC-5ltqA:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mwc | GENETICALLY-ENCODEDGREEN CALCIUMINDICATOR NTNC (syntheticconstruct) |
no annotation | 6 | TYR D 74TYR D 114GLY D 123GLU D 18PHE D 293HIS D 72 | NoneCR2 D 70 ( 4.5A)NoneNoneCR2 D 70 ( 4.5A)CR2 D 70 ( 4.1A) | 1.22A | 4wcxC-5mwcD:undetectable | 4wcxC-5mwcD:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mwc | GENETICALLY-ENCODEDGREEN CALCIUMINDICATOR NTNC (syntheticconstruct) |
no annotation | 5 | TYR D 114GLY D 123GLU D 18PRO D 40ALA D 87 | CR2 D 70 ( 4.5A)NoneNoneNoneNone | 1.23A | 4wcxC-5mwcD:undetectable | 4wcxC-5mwcD:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ok4 | 5,10-METHENYLTETRAHYDROMETHANOPTERINHYDROGENASE (Methanothermobactermarburgensis) |
no annotation | 5 | TYR A 202GLY A 233GLU A 231LEU A 243HIS A 203 | NoneNoneNoneNone FE A 401 ( 3.2A) | 1.24A | 4wcxC-5ok4A:undetectable | 4wcxC-5ok4A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vfz | GP33 (Mycobacteriumvirus Brujita) |
no annotation | 5 | GLU A 214GLY A 218GLU A 222PRO A 206HIS A 210 | None | 1.18A | 4wcxC-5vfzA:undetectable | 4wcxC-5vfzA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wug | BETA-GLUCOSIDASE (Paenibacillusbarengoltzii) |
no annotation | 5 | TYR A 414GLU A 410GLY A 412PRO A 462ALA A 365 | None | 1.25A | 4wcxC-5wugA:2.4 | 4wcxC-5wugA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yew | MITOFUSIN-1,MITOFUSIN-1 FUSION PROTEIN (Homo sapiens) |
no annotation | 5 | GLU B 56GLU B 37LEU B 64LEU B 25ALA B 719 | None | 1.22A | 4wcxC-5yewB:3.3 | 4wcxC-5yewB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fg8 | SOMATICEMBRYOGENESISRECEPTOR KINASE 1 (Arabidopsisthaliana) |
no annotation | 5 | TYR A 101GLY A 77LEU A 119LEU A 143ARG A 144 | None | 1.12A | 4wcxC-6fg8A:undetectable | 4wcxC-6fg8A:undetectable |