SIMILAR PATTERNS OF AMINO ACIDS FOR 4WCX_C_SAMC503

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ais PROTEIN
(TRANSCRIPTION
INITIATION FACTOR
IIB)

(Pyrococcus
woesei) 		PF00382
(TFIIB) 		5 TYR B1190
GLY B1187
GLU B1185
LEU B1125
ALA B1162
 None
 1.23A 4wcxC-1aisB:
undetectable		 4wcxC-1aisB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3n PROTEIN (KETOACYL
ACYL CARRIER PROTEIN
SYNTHASE 2)

(Escherichia
coli) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 343
LEU A 407
ARG A 175
ALA A 173
HIS A 172
 None
 1.23A 4wcxC-1b3nA:
undetectable		 4wcxC-1b3nA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b65 PROTEIN
(AMINOPEPTIDASE)

(Ochrobactrum
anthropi) 		PF03576
(Peptidase_S58) 		5 GLY A 205
LEU A 261
LEU A 269
ARG A 272
ALA A 327
 None
 1.21A 4wcxC-1b65A:
undetectable		 4wcxC-1b65A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		5 GLU A 284
PHE A 275
LEU A 270
PRO A 259
LEU A 226
 None
 1.05A 4wcxC-1c3rA:
undetectable		 4wcxC-1c3rA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3r HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN)

(Aquifex
aeolicus) 		PF00850
(Hist_deacetyl) 		5 PHE A 275
LEU A 270
PRO A 259
LEU A 226
ALA A 234
 None
 1.12A 4wcxC-1c3rA:
undetectable		 4wcxC-1c3rA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT I

(Salmonella
enterica) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 TYR A 176
GLY A 148
LEU A 130
LEU A  80
ALA A  58
 None
 1.01A 4wcxC-1i1qA:
undetectable		 4wcxC-1i1qA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ir6 EXONUCLEASE RECJ

(Thermus
thermophilus) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 GLY A 170
GLU A 144
LEU A 194
LEU A 198
ALA A  63
 None
 1.20A 4wcxC-1ir6A:
undetectable		 4wcxC-1ir6A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1of3 BETA-MANNOSIDASE

(Thermotoga
maritima) 		PF09212
(CBM27) 		5 TYR A  83
GLY A  44
LEU A  78
ARG A 135
HIS A 133
 None
CA  A1174 (-4.2A)
None
None
None
 1.12A 4wcxC-1of3A:
undetectable		 4wcxC-1of3A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		6 GLY A1083
GLU A1086
LEU A1219
LEU A 845
ARG A1206
ALA A 841
 None
 1.49A 4wcxC-1ofeA:
7.8		 4wcxC-1ofeA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1og3 T-CELL
ECTO-ADP-RIBOSYLTRAN
SFERASE 2

(Rattus
norvegicus) 		PF01129
(ART) 		5 GLU A 196
LEU A 116
PRO A  64
ALA A  74
HIS A  71
 None
 1.20A 4wcxC-1og3A:
undetectable		 4wcxC-1og3A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qor QUINONE
OXIDOREDUCTASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 TYR A  95
GLU A 312
GLY A  12
LEU A 304
ALA A  18
 None
 1.27A 4wcxC-1qorA:
2.4		 4wcxC-1qorA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qor QUINONE
OXIDOREDUCTASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 TYR A  95
GLU A 312
LEU A 325
LEU A 304
ALA A  18
 None
 1.24A 4wcxC-1qorA:
2.4		 4wcxC-1qorA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)

(Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 TYR A 239
GLU A 158
GLY A 237
PRO A 152
LEU A 280
 None
 1.18A 4wcxC-1rblA:
2.9		 4wcxC-1rblA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvk ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 TYR A 328
GLY A 282
GLU A 258
ALA A 320
HIS A 317
 None
None
MG  A 999 (-2.5A)
None
None
 1.12A 4wcxC-1rvkA:
10.9		 4wcxC-1rvkA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 TYR A 232
GLU A 151
GLY A 230
PRO A 145
LEU A 273
 None
 1.24A 4wcxC-1svdA:
8.2		 4wcxC-1svdA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t2w SORTASE

(Staphylococcus
aureus) 		PF04203
(Sortase) 		5 TYR A 187
GLY A  90
GLU A 106
ALA A 184
HIS A 120
 None
None
None
THR  A 334 ( 4.6A)
None
 1.12A 4wcxC-1t2wA:
undetectable		 4wcxC-1t2wA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v19 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermus
thermophilus) 		PF00294
(PfkB) 		5 GLY A 290
GLU A 289
LEU A  43
LEU A 258
ALA A 274
 None
 1.19A 4wcxC-1v19A:
3.1		 4wcxC-1v19A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x55 ASPARAGINYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		5 GLU A 309
GLY A 354
GLU A 353
LEU A 221
HIS A 220
 None
None
None
NSS  A3002 (-4.7A)
PO4  A3001 ( 4.1A)
 0.99A 4wcxC-1x55A:
undetectable		 4wcxC-1x55A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytk NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE FROM
THERMOPLASMA
ACIDOPHILUM

(Thermoplasma
acidophilum) 		PF01729
(QRPTase_C) 		5 GLU A 345
PRO A  91
LEU A  88
ARG A  83
ALA A  85
 None
 1.25A 4wcxC-1ytkA:
5.0		 4wcxC-1ytkA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 GLY A  24
GLU A  50
LEU A 461
LEU A 468
ALA A 431
 None
 1.13A 4wcxC-2ag1A:
undetectable		 4wcxC-2ag1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG

(Thermus
thermophilus) 		PF01887
(SAM_adeno_trans) 		5 GLY A 214
GLU A 215
LEU A 246
ARG A 241
ALA A 243
 None
 1.08A 4wcxC-2cw5A:
undetectable		 4wcxC-2cw5A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx7 STEROL CARRIER
PROTEIN 2

(Thermus
thermophilus) 		PF02036
(SCP2) 		5 GLY A  89
GLU A  85
LEU A  35
LEU A  33
ALA A 119
 None
 1.16A 4wcxC-2cx7A:
undetectable		 4wcxC-2cx7A:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 TYR A 614
TYR A 661
GLY A 660
GLU A 663
PRO A 527
 None
 1.17A 4wcxC-2ecfA:
undetectable		 4wcxC-2ecfA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hy5 PUTATIVE
SULFURTRANSFERASE
DSRE

(Allochromatium
vinosum) 		PF02635
(DrsE) 		5 TYR A  40
GLY A  86
LEU A 112
LEU A 115
ARG A  36
 None
 1.12A 4wcxC-2hy5A:
2.1		 4wcxC-2hy5A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2izo FLAP
STRUCTURE-SPECIFIC
ENDONUCLEASE

(Sulfolobus
solfataricus) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 PHE A  13
LEU A  11
PRO A 204
LEU A 206
ALA A 165
 None
 0.95A 4wcxC-2izoA:
undetectable		 4wcxC-2izoA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4g HYALURONOGLUCOSAMINI
DASE

(Bacteroides
thetaiotaomicron) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		5 TYR A  81
GLY A  99
GLU A  61
LEU A  44
LEU A 111
 None
 1.20A 4wcxC-2j4gA:
5.0		 4wcxC-2j4gA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j86 PROTEIN
SERINE-THREONINE
PHOSPHATASE

(Synechococcus
elongatus) 		PF13672
(PP2C_2) 		5 TYR A 123
GLY A 194
GLU A 197
LEU A 130
ARG A 187
 None
None
MG  A1241 ( 4.6A)
None
None
 1.00A 4wcxC-2j86A:
undetectable		 4wcxC-2j86A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jar 5'(3')-DEOXYRIBONUCL
EOTIDASE

(Mus musculus) 		PF06941
(NT5C) 		5 TYR A 115
GLY A 112
GLU A 113
LEU A  17
LEU A  86
 None
 1.23A 4wcxC-2jarA:
undetectable		 4wcxC-2jarA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kii PUTATIVE
UNCHARACTERIZED
PROTEIN

(Shewanella
oneidensis) 		PF07700
(HNOB) 		5 TYR A  36
GLU A  46
PHE A  69
LEU A  73
LEU A  77
 None
None
None
None
HEM  A 182 ( 2.9A)
 1.22A 4wcxC-2kiiA:
undetectable		 4wcxC-2kiiA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		5 GLU A 366
GLY A 359
LEU A 250
LEU A 177
ALA A 167
 None
HEM  A 501 ( 3.9A)
None
None
None
 1.18A 4wcxC-2m56A:
undetectable		 4wcxC-2m56A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		5 GLY A 203
GLU A 201
PHE A  89
ARG A 125
ALA A 127
 4PA  A 369 ( 3.7A)
None
None
None
None
 1.19A 4wcxC-2o7rA:
2.1		 4wcxC-2o7rA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxf URIDINE
PHOSPHORYLASE

(Salmonella
enterica) 		PF01048
(PNP_UDP_1) 		5 GLY A1068
LEU A1011
LEU A1016
ARG A1054
ALA A1022
 None
 1.17A 4wcxC-2oxfA:
undetectable		 4wcxC-2oxfA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p91 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Aquifex
aeolicus) 		PF13561
(adh_short_C2) 		5 GLU A  84
LEU A 148
LEU A 100
ARG A  23
ALA A  51
 None
 1.04A 4wcxC-2p91A:
2.3		 4wcxC-2p91A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfm PUTATIVE ANKYRIN
REPEAT PROTEIN
TV1425

(Thermoplasma
volcanium) 		PF12796
(Ank_2)
PF13857
(Ank_5) 		5 GLY A 131
GLU A 130
LEU A 102
LEU A 118
ALA A 155
 None
 1.25A 4wcxC-2rfmA:
undetectable		 4wcxC-2rfmA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjb UNCHARACTERIZED
PROTEIN

(Shigella
flexneri) 		PF07063
(DUF1338) 		5 GLU A 271
GLU A  25
PHE A 288
ALA A 212
HIS A 205
 None
 1.14A 4wcxC-2rjbA:
undetectable		 4wcxC-2rjbA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjb UNCHARACTERIZED
PROTEIN

(Shigella
flexneri) 		PF07063
(DUF1338) 		5 GLU A 271
GLU A  25
PHE A 288
LEU A 210
HIS A 205
 None
 1.08A 4wcxC-2rjbA:
undetectable		 4wcxC-2rjbA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqa SLL1358 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00190
(Cupin_1) 		5 GLY A 171
GLU A 170
PRO A 203
LEU A 180
HIS A 182
 None
MN  A1005 ( 4.9A)
None
None
None
 1.15A 4wcxC-2vqaA:
undetectable		 4wcxC-2vqaA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3p BENZOYL-COA-DIHYDROD
IOL LYASE

(Paraburkholderia
xenovorans) 		PF00378
(ECH_1) 		5 TYR A  48
GLY A  47
LEU A 540
LEU A 172
ALA A  94
 None
None
None
None
BME  A 601 ( 4.5A)
 1.25A 4wcxC-2w3pA:
undetectable		 4wcxC-2w3pA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww8 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF13519
(VWA_2) 		5 GLU A 181
GLY A 187
GLU A 186
LEU A 623
ALA A 625
 EPE  A1101 (-3.2A)
None
None
None
None
 1.27A 4wcxC-2ww8A:
undetectable		 4wcxC-2ww8A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yx0 RADICAL SAM ENZYME

(Pyrococcus
horikoshii) 		PF04055
(Radical_SAM)
PF08608
(Wyosine_form) 		5 GLU A 152
PHE A 228
LEU A 229
LEU A 260
ALA A 204
 None
 1.03A 4wcxC-2yx0A:
10.6		 4wcxC-2yx0A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyl 4-HYDROXYPHENYLACETA
TE-3-HYDROXYLASE

(Thermus
thermophilus) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		5 GLY A 276
LEU A 351
PRO A  74
ALA A 339
HIS A 286
 None
 1.25A 4wcxC-2yylA:
2.3		 4wcxC-2yylA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuy YESX PROTEIN

(Bacillus
subtilis) 		PF01839
(FG-GAP) 		5 GLY A 240
GLU A 241
PHE A 166
LEU A 546
ALA A 121
 None
 1.27A 4wcxC-2zuyA:
undetectable		 4wcxC-2zuyA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		5 GLY A 708
LEU A 333
LEU A 403
ALA A 384
HIS A 381
 None
 1.04A 4wcxC-3aqpA:
undetectable		 4wcxC-3aqpA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2l SAM-DEPENDENT
METHYLTRANSFERASE

(Exiguobacterium
sibiricum) 		PF13649
(Methyltransf_25) 		5 TYR A  54
GLU A  31
GLY A  33
LEU A 126
LEU A 132
 None
 1.24A 4wcxC-3d2lA:
2.2		 4wcxC-3d2lA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2v 3'-5'-EXONUCLEASE

(Saccharomyces
cerevisiae) 		PF01026
(TatD_DNase) 		5 GLU A 387
GLU A 332
PHE A 357
LEU A  68
ALA A  79
 None
GOL  A 426 (-2.9A)
None
None
None
 0.97A 4wcxC-3e2vA:
8.2		 4wcxC-3e2vA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq2 PROBABLE
TWO-COMPONENT
RESPONSE REGULATOR

(Pseudomonas
aeruginosa) 		PF00072
(Response_reg)
PF07228
(SpoIIE) 		5 GLU A 178
GLY A 176
GLU A 175
LEU A 331
LEU A 294
 None
 1.25A 4wcxC-3eq2A:
3.4		 4wcxC-3eq2A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ff6 ACETYL-COA
CARBOXYLASE 2

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		5 TYR A2192
GLY A2226
LEU A2317
LEU A2326
ARG A2329
 None
 1.24A 4wcxC-3ff6A:
2.4		 4wcxC-3ff6A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C) 		5 TYR A1332
GLY A1383
PHE A1223
LEU A1291
LEU A1290
 None
 1.26A 4wcxC-3hmjA:
2.5		 4wcxC-3hmjA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA

(Homo sapiens) 		PF00041
(fn3)
PF06328
(Lep_receptor_Ig)
PF09240
(IL6Ra-bind) 		5 TYR A 470
GLY A 527
LEU A 464
LEU A 460
ALA A 410
 None
 1.17A 4wcxC-3l5hA:
undetectable		 4wcxC-3l5hA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5j INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA

(Homo sapiens) 		PF00041
(fn3) 		5 TYR A 470
GLY A 527
LEU A 464
LEU A 460
ALA A 410
 None
 1.14A 4wcxC-3l5jA:
undetectable		 4wcxC-3l5jA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2x UNCHARACTERIZED
PROTEIN YAGE

(Escherichia
coli) 		PF00701
(DHDPS) 		5 GLY A  57
GLU A  59
LEU A 299
LEU A 303
ALA A 226
 MCL  A 174 ( 3.6A)
None
None
None
None
 1.09A 4wcxC-3n2xA:
5.8		 4wcxC-3n2xA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p4s FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 TYR A 199
GLY A 196
LEU A 512
LEU A 482
ALA A 458
 None
 1.04A 4wcxC-3p4sA:
4.9		 4wcxC-3p4sA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q87 N6 ADENINE SPECIFIC
DNA METHYLASE

(Encephalitozoon
cuniculi) 		PF05175
(MTS) 		5 TYR B 141
GLY B 161
LEU B  30
LEU B  70
ALA B 113
 None
None
None
SAM  B 300 (-4.4A)
None
 1.24A 4wcxC-3q87B:
2.7		 4wcxC-3q87B:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ruy ORNITHINE
AMINOTRANSFERASE

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		5 TYR A  88
GLY A  85
LEU A 257
LEU A 253
ALA A 268
 None
 1.08A 4wcxC-3ruyA:
undetectable		 4wcxC-3ruyA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u0b OXIDOREDUCTASE,
SHORT CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 TYR A  64
LEU A  44
LEU A  66
ARG A  57
ALA A  59
 None
None
NA  A 451 ( 4.9A)
None
None
 1.11A 4wcxC-3u0bA:
undetectable		 4wcxC-3u0bA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u5r UNCHARACTERIZED
PROTEIN

(Sinorhizobium
meliloti) 		PF00578
(AhpC-TSA) 		5 TYR E 123
GLU E  79
GLY E 122
LEU E 178
ALA E  65
 None
 0.96A 4wcxC-3u5rE:
undetectable		 4wcxC-3u5rE:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vw5 CELLOBIOSE
2-EPIMERASE

(Ruminococcus
albus) 		PF07221
(GlcNAc_2-epim) 		5 GLU A  78
GLY A  28
LEU A 119
LEU A 138
ARG A 137
 None
 1.04A 4wcxC-3vw5A:
2.2		 4wcxC-3vw5A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w04 DWARF 88 ESTERASE

(Oryza sativa) 		PF12697
(Abhydrolase_6) 		5 GLY A 171
PHE A 143
LEU A 100
ALA A  84
HIS A  76
 None
 1.22A 4wcxC-3w04A:
undetectable		 4wcxC-3w04A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aj9 CATALASE-3

(Neurospora
crassa) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 TYR A 240
GLY A 235
PHE A 291
LEU A 296
HIS A 242
 None
 1.27A 4wcxC-4aj9A:
3.0		 4wcxC-4aj9A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4amc GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		5 TYR A1322
GLY A1327
LEU A1346
LEU A1341
ALA A1371
 None
 1.27A 4wcxC-4amcA:
4.4		 4wcxC-4amcA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8o AAC(6')-IH PROTEIN

(Acinetobacter
baumannii) 		PF00583
(Acetyltransf_1) 		5 GLY A 131
LEU A  58
LEU A  43
ARG A  42
ALA A  76
 None
 1.24A 4wcxC-4e8oA:
undetectable		 4wcxC-4e8oA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2t SSFS6

(Streptomyces
sp. SF2575) 		PF00201
(UDPGT)
PF06722
(DUF1205) 		5 GLU A 115
GLY A  12
GLU A  11
LEU A  63
ALA A 315
 None
TYD  A 401 ( 3.7A)
None
None
None
 1.10A 4wcxC-4g2tA:
undetectable		 4wcxC-4g2tA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyi RIO2 KINASE

(Chaetomium
thermophilum) 		PF01163
(RIO1)
PF09202
(Rio2_N) 		5 GLY A 105
LEU A 123
ARG A 184
ALA A 159
HIS A 185
 ADP  A 401 ( 4.8A)
None
None
None
EDO  A 403 (-4.1A)
 1.27A 4wcxC-4gyiA:
undetectable		 4wcxC-4gyiA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvf GREEN FLUORESCENT
PROTEIN BLFP-Y6

(Branchiostoma
lanceolatum) 		PF01353
(GFP) 		5 TYR A  64
TYR A 105
GLY A 114
GLU A   8
PHE A 209
 None
CR2  A  58 ( 4.5A)
None
None
CR2  A  58 ( 4.5A)
 1.24A 4wcxC-4hvfA:
undetectable		 4wcxC-4hvfA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvf GREEN FLUORESCENT
PROTEIN BLFP-Y6

(Branchiostoma
lanceolatum) 		PF01353
(GFP) 		5 TYR A 105
GLY A 114
GLU A   8
PRO A  30
ALA A  78
 CR2  A  58 ( 4.5A)
None
None
None
None
 1.24A 4wcxC-4hvfA:
undetectable		 4wcxC-4hvfA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m4d LIPOPOLYSACCHARIDE-B
INDING PROTEIN

(Mus musculus) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		5 TYR A 212
LEU A 144
PRO A 236
LEU A 101
ALA A  42
 PC1  A 506 (-3.7A)
None
None
None
PC1  A 506 (-3.6A)
 1.20A 4wcxC-4m4dA:
undetectable		 4wcxC-4m4dA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkv RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Pisum sativum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 TYR A 239
GLU A 158
GLY A 237
PRO A 152
LEU A 280
 None
 1.19A 4wcxC-4mkvA:
4.7		 4wcxC-4mkvA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n9w GDP-MANNOSE-DEPENDEN
T
ALPHA-(1-2)-PHOSPHAT
IDYLINOSITOL
MANNOSYLTRANSFERASE

(Mycolicibacterium
smegmatis) 		PF13439
(Glyco_transf_4)
PF13692
(Glyco_trans_1_4) 		5 GLY A 249
GLU A 231
LEU A 207
PRO A 269
ALA A 263
 None
 1.25A 4wcxC-4n9wA:
2.4		 4wcxC-4n9wA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq3 CYANURIC ACID
AMIDOHYDROLASE

(Azorhizobium
caulinodans) 		PF09663
(Amido_AtzD_TrzD) 		5 GLY A 273
LEU A 107
LEU A 239
ALA A 348
HIS A 151
 None
 1.21A 4wcxC-4nq3A:
undetectable		 4wcxC-4nq3A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oa7 TANKYRASE-1

(Homo sapiens) 		PF00644
(PARP) 		5 TYR A1213
GLY A1211
GLU A1199
LEU A1256
ALA A1215
 2XS  A1402 (-4.2A)
None
None
None
None
 1.09A 4wcxC-4oa7A:
undetectable		 4wcxC-4oa7A:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE

(Escherichia
coli) 		PF00701
(DHDPS) 		5 GLY A  57
GLU A  59
LEU A 299
LEU A 303
ALA A 226
 PYR  A 410 ( 3.4A)
None
None
None
None
 1.08A 4wcxC-4oe7A:
12.3		 4wcxC-4oe7A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdy AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Alicyclobacillus
acidocaldarius) 		PF01636
(APH) 		5 PHE A 134
LEU A 131
LEU A 259
ARG A 262
ALA A 116
 None
 1.06A 4wcxC-4pdyA:
undetectable		 4wcxC-4pdyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe2 MALTOSE ABC
TRANSPORTER
PERIPLASMIC
PROTEIN,PREPILIN-TYP
E N-TERMINAL
CLEAVAGE/METHYLATION
DOMAIN PROTEIN

(Escherichia
coli;
Clostridioides
difficile) 		PF13416
(SBP_bac_8) 		5 TYR A 307
GLY A  19
GLU A  22
LEU A 311
ALA A 109
 None
 1.26A 4wcxC-4pe2A:
undetectable		 4wcxC-4pe2A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qgo DNA-ENTRY NUCLEASE
(COMPETENCE-SPECIFIC
NUCLEASE)

(Streptococcus
agalactiae) 		PF01223
(Endonuclease_NS) 		5 TYR A 192
GLY A 188
LEU A 154
LEU A 106
ALA A 229
 None
 1.11A 4wcxC-4qgoA:
undetectable		 4wcxC-4qgoA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r33 NOSL

(Streptomyces
actuosus) 		PF06968
(BATS) 		6 GLY A 142
GLU A 143
PHE A 202
LEU A 250
PRO A 283
ALA A 288
 SAH  A 501 (-3.6A)
None
SAH  A 501 ( 4.6A)
SAH  A 501 ( 3.6A)
None
SAH  A 501 ( 3.7A)
 0.60A 4wcxC-4r33A:
38.0		 4wcxC-4r33A:
29.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 343
LEU A 407
ARG A 175
ALA A 173
HIS A 172
 None
 1.27A 4wcxC-4r8eA:
undetectable		 4wcxC-4r8eA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9o PUTATIVE ALDO/KETO
REDUCTASE

(Salmonella
enterica) 		PF00248
(Aldo_ket_red) 		5 GLU A 267
LEU A  42
LEU A  74
ARG A  75
ALA A  67
 None
 1.23A 4wcxC-4r9oA:
6.2		 4wcxC-4r9oA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9o PUTATIVE ALDO/KETO
REDUCTASE

(Salmonella
enterica) 		PF00248
(Aldo_ket_red) 		5 GLY A 264
LEU A  42
LEU A  74
ARG A  75
ALA A  67
 None
 1.07A 4wcxC-4r9oA:
6.2		 4wcxC-4r9oA:
19.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rtb HYDG PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		8 TYR A  94
GLY A 134
GLU A 135
PHE A 187
LEU A 231
PRO A 265
LEU A 267
ALA A 270
 SAM  A 501 (-4.5A)
SF4  A 502 ( 3.9A)
None
SAM  A 501 (-4.3A)
SAM  A 501 (-4.1A)
None
SAM  A 501 (-4.4A)
SAM  A 501 ( 3.7A)
 0.39A 4wcxC-4rtbA:
46.2		 4wcxC-4rtbA:
43.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvs PROBABLE QUINONE
REDUCTASE QOR
(NADPH:QUINONE
REDUCTASE)
(ZETA-CRYSTALLIN
HOMOLOG PROTEIN)

(Mycobacterium
tuberculosis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 292
GLU A 294
LEU A 166
ALA A 130
HIS A 131
 None
 1.22A 4wcxC-4rvsA:
undetectable		 4wcxC-4rvsA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvs PROBABLE QUINONE
REDUCTASE QOR
(NADPH:QUINONE
REDUCTASE)
(ZETA-CRYSTALLIN
HOMOLOG PROTEIN)

(Mycobacterium
tuberculosis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 292
GLU A 294
LEU A 166
LEU A 134
HIS A 131
 None
 1.21A 4wcxC-4rvsA:
undetectable		 4wcxC-4rvsA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um2 TELOMERASE-BINDING
PROTEIN EST1A

(Homo sapiens) 		PF10373
(EST1_DNA_bind)
PF10374
(EST1) 		5 TYR A 787
GLY A 766
PHE A 948
LEU A 783
ALA A 776
 None
 1.20A 4wcxC-4um2A:
4.2		 4wcxC-4um2A:
23.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wcx BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED

(Thermoanaerobacter
italicus) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		11 TYR A  96
TYR A  99
GLU A 133
GLY A 135
GLU A 136
PHE A 192
LEU A 236
PRO A 270
LEU A 272
ARG A 273
ALA A 275
 None
MET  A 503 (-3.4A)
MET  A 503 (-3.2A)
MET  A 503 ( 3.6A)
None
None
None
None
None
None
None
 0.75A 4wcxC-4wcxA:
61.5		 4wcxC-4wcxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 GLY A1200
GLU A1202
LEU A1093
LEU A1069
ALA A1078
 EDO  A2423 ( 3.7A)
None
None
None
None
 1.25A 4wcxC-5a55A:
4.2		 4wcxC-5a55A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3g PROTEIN SHORT-ROOT

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		5 GLU B 485
LEU B 276
PRO B 284
LEU B 286
ALA B 354
 None
 0.98A 4wcxC-5b3gB:
2.6		 4wcxC-5b3gB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3h PROTEIN SHORT-ROOT

(Arabidopsis
thaliana) 		PF03514
(GRAS) 		5 GLU B 485
LEU B 276
PRO B 284
LEU B 286
ALA B 354
 None
 1.07A 4wcxC-5b3hB:
2.6		 4wcxC-5b3hB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hb4 NUP192,NUCLEOPORIN
NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 TYR B1424
LEU B1420
LEU B1423
ARG B1366
ALA B1368
 None
 1.23A 4wcxC-5hb4B:
2.2		 4wcxC-5hb4B:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jq9 DIHYDROPTEROATE
SYNTHASE

(Yersinia pestis) 		PF00809
(Pterin_bind) 		5 GLY A  59
GLU A  73
ARG A  46
ALA A  44
HIS A  43
 None
None
EDO  A 302 ( 4.3A)
None
EDO  A 302 ( 4.8A)
 1.13A 4wcxC-5jq9A:
13.5		 4wcxC-5jq9A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8o 5-NITROANTHRANILIC
ACID AMINOHYDROLASE

(Bradyrhizobium
sp.) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 TYR A 388
GLY A 389
GLU A 196
LEU A  81
LEU A 420
 None
None
MN  A 501 ( 1.8A)
None
None
 1.25A 4wcxC-5k8oA:
2.2		 4wcxC-5k8oA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE DELTA
SUBUNIT

(Aromatoleum
aromaticum) 		PF02538
(Hydantoinase_B) 		5 GLU A 301
GLY A 299
LEU A   6
ALA A 312
HIS A 309
 None
 1.16A 4wcxC-5l9wA:
undetectable		 4wcxC-5l9wA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltq GREEN FLUORESCENT
PROTEIN BLFP-Y3

(Branchiostoma
lanceolatum) 		PF01353
(GFP) 		5 TYR A  64
TYR A 104
GLY A 113
GLU A   8
HIS A  62
 None
CR2  A  59 ( 4.6A)
None
None
CR2  A  59 (-4.1A)
 1.02A 4wcxC-5ltqA:
undetectable		 4wcxC-5ltqA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltq GREEN FLUORESCENT
PROTEIN BLFP-Y3

(Branchiostoma
lanceolatum) 		PF01353
(GFP) 		5 TYR A  64
TYR A 104
GLY A 113
PHE A 208
HIS A  62
 None
CR2  A  59 ( 4.6A)
None
CR2  A  59 ( 4.6A)
CR2  A  59 (-4.1A)
 1.06A 4wcxC-5ltqA:
undetectable		 4wcxC-5ltqA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltq GREEN FLUORESCENT
PROTEIN BLFP-Y3

(Branchiostoma
lanceolatum) 		PF01353
(GFP) 		5 TYR A 104
GLY A 113
GLU A   8
PRO A  30
ALA A  77
 CR2  A  59 ( 4.6A)
None
None
None
None
 1.21A 4wcxC-5ltqA:
undetectable		 4wcxC-5ltqA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC

(synthetic
construct) 		no annotation 6 TYR D  74
TYR D 114
GLY D 123
GLU D  18
PHE D 293
HIS D  72
 None
CR2  D  70 ( 4.5A)
None
None
CR2  D  70 ( 4.5A)
CR2  D  70 ( 4.1A)
 1.22A 4wcxC-5mwcD:
undetectable		 4wcxC-5mwcD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwc GENETICALLY-ENCODED
GREEN CALCIUM
INDICATOR NTNC

(synthetic
construct) 		no annotation 5 TYR D 114
GLY D 123
GLU D  18
PRO D  40
ALA D  87
 CR2  D  70 ( 4.5A)
None
None
None
None
 1.23A 4wcxC-5mwcD:
undetectable		 4wcxC-5mwcD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ok4 5,10-METHENYLTETRAHY
DROMETHANOPTERIN
HYDROGENASE

(Methanothermobacter
marburgensis) 		no annotation 5 TYR A 202
GLY A 233
GLU A 231
LEU A 243
HIS A 203
 None
None
None
None
FE  A 401 ( 3.2A)
 1.24A 4wcxC-5ok4A:
undetectable		 4wcxC-5ok4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfz GP33

(Mycobacterium
virus Brujita) 		no annotation 5 GLU A 214
GLY A 218
GLU A 222
PRO A 206
HIS A 210
 None
 1.18A 4wcxC-5vfzA:
undetectable		 4wcxC-5vfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 5 TYR A 414
GLU A 410
GLY A 412
PRO A 462
ALA A 365
 None
 1.25A 4wcxC-5wugA:
2.4		 4wcxC-5wugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yew MITOFUSIN-1,MITOFUSI
N-1 FUSION PROTEIN

(Homo sapiens) 		no annotation 5 GLU B  56
GLU B  37
LEU B  64
LEU B  25
ALA B 719
 None
 1.22A 4wcxC-5yewB:
3.3		 4wcxC-5yewB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fg8 SOMATIC
EMBRYOGENESIS
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		no annotation 5 TYR A 101
GLY A  77
LEU A 119
LEU A 143
ARG A 144
 None
 1.12A 4wcxC-6fg8A:
undetectable		 4wcxC-6fg8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmm PROTEIN I/II
V-REGION

(Streptococcus
mutans) 		PF08363
(GbpC) 		4 LEU A 736
GLU A 742
LYS A 805
TYR A 750
 None
 1.48A 4wcxC-1jmmA:
undetectable		 4wcxC-1jmmA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9e METHYL PARATHION
HYDROLASE

(Pseudomonas sp.
WBC-3) 		PF00753
(Lactamase_B) 		4 ASN A 219
LEU A 229
GLU A 283
LYS A 286
 None
 1.42A 4wcxC-1p9eA:
undetectable		 4wcxC-1p9eA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5h L-LYSINE
2,3-AMINOMUTASE

(Clostridium
subterminale) 		PF04055
(Radical_SAM)
PF12544
(LAM_C) 		4 CYH A 129
ASN A 266
LEU A 275
GLU A 236
 SF4  A 418 (-2.3A)
None
None
None
 1.30A 4wcxC-2a5hA:
11.2		 4wcxC-2a5hA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2c SPERMIDINE SYNTHASE

(Caenorhabditis
elegans) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 CYH A 157
ASN A 290
LEU A 291
GLU A 125
 None
 1.36A 4wcxC-2b2cA:
undetectable		 4wcxC-2b2cA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bfu COWPEA MOSAIC VIRUS,
SMALL (S) SUBUNIT

(Cowpea mosaic
virus) 		PF02248
(Como_SCP) 		4 ASN S 119
LEU S 118
GLU S 160
TYR S  11
 None
 1.28A 4wcxC-2bfuS:
undetectable		 4wcxC-2bfuS:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5o ACTIVATING SIGNAL
COINTEGRATOR 1

(Homo sapiens) 		PF04266
(ASCH) 		4 ASN A  73
GLU A 119
LYS A 123
TYR A  75
 None
 1.07A 4wcxC-2e5oA:
undetectable		 4wcxC-2e5oA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT
ETHYLBENZENE
DEHYDROGENASE
BETA-SUBUNIT

(Aromatoleum
aromaticum;
Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF13247
(Fer4_11) 		4 CYH B  28
ASN B 129
LEU A 867
TYR B 146
 SF4  B1358 (-2.2A)
None
None
None
 1.16A 4wcxC-2ivfB:
undetectable		 4wcxC-2ivfB:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayh DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC9
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF03874
(RNA_pol_Rpb4)
PF03876
(SHS2_Rpb7-N)
PF08292
(RNA_pol_Rbc25) 		4 ASN A  13
LEU A  88
GLU B  83
TYR A  55
 None
 1.46A 4wcxC-3ayhA:
undetectable		 4wcxC-3ayhA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cl6 PUUE ALLANTOINASE

(Pseudomonas
fluorescens) 		PF01522
(Polysacc_deac_1) 		4 CYH A 186
ASN A  34
LEU A 258
TYR A 164
 None
 1.32A 4wcxC-3cl6A:
6.9		 4wcxC-3cl6A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3u PEPTIDE DEFORMYLASE

(Mycobacterium
tuberculosis) 		PF01327
(Pep_deformylase) 		4 CYH A 106
ASN A  55
LEU A 153
GLU A 149
 NI  A 200 ( 2.3A)
None
None
NVC  A 201 (-2.6A)
 1.33A 4wcxC-3e3uA:
undetectable		 4wcxC-3e3uA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 ASN A 598
GLU A 802
LYS A 837
TYR A 593
 None
 1.15A 4wcxC-3ecqA:
2.1		 4wcxC-3ecqA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fiq ODORANT-BINDING
PROTEIN 1F

(Rattus
norvegicus) 		PF00061
(Lipocalin) 		4 ASN A 125
LEU A 124
GLU A 131
LYS A  92
 None
 1.41A 4wcxC-3fiqA:
undetectable		 4wcxC-3fiqA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		4 CYH A 488
LEU A 406
GLU A 390
TYR A 464
 None
 1.38A 4wcxC-3pfqA:
undetectable		 4wcxC-3pfqA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thc BETA-GALACTOSIDASE

(Homo sapiens) 		PF01301
(Glyco_hydro_35)
PF13364
(BetaGal_dom4_5) 		4 ASN A 318
GLU A 478
LYS A 578
TYR A 324
 None
 1.18A 4wcxC-3thcA:
10.0		 4wcxC-3thcA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 ASN A1016
LEU A1177
GLU A1182
TYR A1187
 None
 1.40A 4wcxC-4bedA:
undetectable		 4wcxC-4bedA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		4 CYH A 894
ASN A1016
LEU A1176
GLU A1182
 CUO  A9003 (-3.1A)
None
None
None
 1.11A 4wcxC-4bedA:
undetectable		 4wcxC-4bedA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btm TAU-TUBULIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 CYH A 115
ASN A 183
GLU A 101
LYS A  87
 F8E  A1340 (-3.2A)
None
None
F8E  A1340 ( 4.0A)
 1.09A 4wcxC-4btmA:
undetectable		 4wcxC-4btmA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyo ASPARTYL
AMINOPEPTIDASE

(Homo sapiens) 		PF02127
(Peptidase_M18) 		4 CYH A 241
ASN A 300
GLU A 239
TYR A 121
 None
 1.45A 4wcxC-4dyoA:
undetectable		 4wcxC-4dyoA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lut ALANINE RACEMASE

(Clostridioides
difficile) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 CYH A 360
LEU A  73
GLU A  69
TYR A  43
 None
None
None
DCS  A 401 (-4.6A)
 1.48A 4wcxC-4lutA:
8.7		 4wcxC-4lutA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mad BETA-GALACTOSIDASE

(Bacillus
circulans) 		PF01301
(Glyco_hydro_35) 		4 ASN A 283
GLU A 443
LYS A 523
TYR A 292
 None
 1.12A 4wcxC-4madA:
6.1		 4wcxC-4madA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu EDS1

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		4 ASN A 404
LEU A 590
GLU A 587
TYR A 395
 None
 1.27A 4wcxC-4nfuA:
3.1		 4wcxC-4nfuA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r33 NOSL

(Streptomyces
actuosus) 		PF06968
(BATS) 		4 CYH A 102
ASN A 175
GLU A 204
LYS A 224
 SF4  A 502 (-2.4A)
SAH  A 501 (-3.9A)
SAH  A 501 (-2.7A)
SAH  A 501 ( 2.8A)
 0.50A 4wcxC-4r33A:
38.1		 4wcxC-4r33A:
29.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rtb HYDG PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		5 CYH A  95
ASN A 164
LEU A 186
GLU A 189
LYS A 205
 SF4  A 502 ( 2.7A)
SAM  A 501 (-3.5A)
None
SAM  A 501 (-2.4A)
SAM  A 501 (-3.3A)
 0.40A 4wcxC-4rtbA:
46.2		 4wcxC-4rtbA:
43.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wcx BIOTIN AND THIAMIN
SYNTHESIS ASSOCIATED

(Thermoanaerobacter
italicus) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		5 CYH A  97
ASN A 169
LEU A 191
GLU A 194
LYS A 210
 SF4  A 501 (-2.1A)
MET  A 503 (-3.2A)
None
SF4  A 501 ( 4.9A)
SF4  A 501 (-3.3A)
 0.26A 4wcxC-4wcxA:
61.1		 4wcxC-4wcxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c3m PUTATIVE
6-PHOSPHO-BETA-GLUCO
SIDASE

(Geobacillus
stearothermophilus) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 CYH A 255
ASN A 150
GLU A 355
TYR A 257
 None
MN  A 501 (-3.4A)
None
None
 1.38A 4wcxC-5c3mA:
undetectable		 4wcxC-5c3mA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hif RECONSTRUCTED
LACTONASE ANCESTOR,
ANC1-MPH

(synthetic
construct) 		PF00753
(Lactamase_B) 		4 ASN A 185
LEU A 195
GLU A 249
LYS A 252
 None
 1.46A 4wcxC-5hifA:
undetectable		 4wcxC-5hifA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzk INTERSECTIN-1,NPH1-1
,INTERSECTIN-1

(Avena sativa;
Homo sapiens) 		PF00621
(RhoGEF)
PF13426
(PAS_9)
PF16652
(PH_13) 		4 CYH B1291
LEU B1245
GLU B1249
TYR B1472
 None
 1.37A 4wcxC-5hzkB:
undetectable		 4wcxC-5hzkB:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k04 UNCHARACTERIZED
PROTEIN
N-TERMINAL
ACETYLTRANSFERASE B
COMPLEX SUBUNIT NAT3

(Candida
albicans;
Candida
albicans) 		PF09797
(NatB_MDM20)
PF08445
(FR47) 		4 LEU A 554
GLU A 369
LYS A 405
TYR B  84
 None
 1.08A 4wcxC-5k04A:
5.7		 4wcxC-5k04A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbj FLAGELLAR
HOOK-ASSOCIATED
PROTEIN FLGK

(Campylobacter
jejuni) 		no annotation 4 ASN A 117
LEU A 113
GLU A 529
TYR A 511
 None
 1.16A 4wcxC-5xbjA:
2.6		 4wcxC-5xbjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuy VINCULIN

(Homo sapiens) 		no annotation 4 ASN A 705
LEU A 671
GLU A 670
LYS A 236
 None
 1.39A 4wcxC-6fuyA:
undetectable		 4wcxC-6fuyA:
undetectable