SIMILAR PATTERNS OF AMINO ACIDS FOR 4WBO_C_ANWC601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 ARG A  91
LEU A  93
ALA A 114
MET A 164
LEU A 217
 None
 0.92A 4wboC-1fotA:
33.6		 4wboC-1fotA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxk MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  70
ALA A  91
MET A 138
LEU A 193
 STU  A 401 (-3.9A)
STU  A 401 (-3.4A)
STU  A 401 (-3.2A)
STU  A 401 (-4.7A)
 0.69A 4wboC-1nxkA:
20.1		 4wboC-1nxkA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 267
ALA A 288
MET A 337
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
 0.50A 4wboC-1opkA:
22.0		 4wboC-1opkA:
26.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  78
ALA A  99
MET A 147
MET A 150
 ATP  A 535 (-3.9A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 3.4A)
None
 0.74A 4wboC-1s9iA:
22.8		 4wboC-1s9iA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  78
ALA A  99
MET A 150
LEU A 201
 ATP  A 535 (-3.9A)
ATP  A 535 (-3.6A)
None
ATP  A 535 (-4.8A)
 0.51A 4wboC-1s9iA:
22.8		 4wboC-1s9iA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 344
ALA A 367
MET A 414
LEU A 468
 STU  A 100 (-3.8A)
STU  A 100 (-3.2A)
STU  A 100 (-3.6A)
STU  A 100 (-4.5A)
 0.57A 4wboC-1u59A:
24.3		 4wboC-1u59A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  18
ALA A  39
MET A  94
LEU A 144
 ATP  A 381 (-4.4A)
ATP  A 381 (-3.6A)
None
None
 0.68A 4wboC-1ua2A:
21.1		 4wboC-1ua2A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU X  17
ALA X  37
MET X  85
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
None
STU  X 902 (-4.4A)
 0.56A 4wboC-2dq7X:
24.3		 4wboC-2dq7X:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyl DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 163
MET A 212
MET A 215
LEU A 266
 None
 0.82A 4wboC-2dylA:
24.2		 4wboC-2dylA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		4 LEU A  19
ALA A  40
MET A  96
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
None
ADP  A 500 (-4.3A)
 0.44A 4wboC-2f9gA:
25.3		 4wboC-2f9gA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 273
ALA A 293
MET A 341
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
None
H8H  A 534 (-4.5A)
 0.52A 4wboC-2h8hA:
20.8		 4wboC-2h8hA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 273
ALA A 293
MET A 341
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-4.4A)
 0.71A 4wboC-2hckA:
20.6		 4wboC-2hckA:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 251
ALA A 271
MET A 319
LEU A 371
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
None
1BM  A 499 (-4.4A)
 0.59A 4wboC-2hk5A:
24.1		 4wboC-2hk5A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 248
ALA A 269
MET A 318
LEU A 370
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
None
GIN  A 600 (-4.7A)
 0.60A 4wboC-2hz0A:
21.9		 4wboC-2hz0A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		4 ARG A 426
ALA A 452
MET A 499
LEU A 553
 None
4ST  A1687 (-3.3A)
4ST  A1687 ( 3.9A)
4ST  A1687 (-4.4A)
 0.92A 4wboC-2j0jA:
14.4		 4wboC-2j0jA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc6 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1D

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  29
ALA A  50
MET A  98
LEU A 151
 QPP  A1314 (-3.7A)
QPP  A1314 ( 3.7A)
QPP  A1314 ( 4.1A)
None
 0.75A 4wboC-2jc6A:
21.0		 4wboC-2jc6A:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ozo TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		4 LEU A 344
ALA A 367
MET A 414
LEU A 468
 ANP  A 615 (-4.4A)
ANP  A 615 (-3.3A)
ANP  A 615 ( 3.9A)
ANP  A 615 (-4.7A)
 0.44A 4wboC-2ozoA:
19.8		 4wboC-2ozoA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3g MAP KINASE-ACTIVATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU X  70
ALA X  91
MET X 138
LEU X 193
 F10  X 401 (-3.9A)
F10  X 401 (-3.4A)
F10  X 401 ( 4.0A)
F10  X 401 ( 4.4A)
 0.73A 4wboC-2p3gX:
18.6		 4wboC-2p3gX:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		4 LEU A  25
ALA A  46
MET A 106
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
None
ATP  A 381 ( 4.8A)
 0.46A 4wboC-2phkA:
26.9		 4wboC-2phkA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmo SER/THR PROTEIN
KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 ARG X  32
LEU X  34
ALA X  53
MET X 120
LEU X 179
 None
HMD  X 400 ( 4.3A)
HMD  X 400 (-3.5A)
None
HMD  X 400 (-4.7A)
 0.79A 4wboC-2pmoX:
26.9		 4wboC-2pmoX:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 724
ALA A 749
MET A 799
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
None
GW7  A   1 (-4.2A)
 0.66A 4wboC-2r4bA:
20.6		 4wboC-2r4bA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 103
MET A 153
MET A 156
LEU A 205
 ANP  A1480 ( 3.9A)
ANP  A1480 (-4.1A)
None
ANP  A1480 ( 4.7A)
 0.45A 4wboC-2v55A:
27.8		 4wboC-2v55A:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU C  55
ALA C  76
MET C 129
LEU C 183
 ANP  C   2 ( 4.4A)
ANP  C   2 (-3.4A)
None
None
 0.71A 4wboC-2wtkC:
28.7		 4wboC-2wtkC:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 226
ALA A 247
MET A 304
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 (-4.6A)
 0.47A 4wboC-2xk9A:
22.4		 4wboC-2xk9A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ARG A1000
LEU A1002
ALA A1028
MET A1076
MET A1079
 None
S91  A   1 ( 4.1A)
S91  A   1 (-3.2A)
S91  A   1 ( 4.9A)
None
 0.74A 4wboC-2z8cA:
25.3		 4wboC-2z8cA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Corynebacterium
glutamicum) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		4 LEU A 444
ALA A 269
MET A 251
MET A 467
 None
 0.79A 4wboC-2zciA:
undetectable		 4wboC-2zciA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 253
ALA A 273
MET A 322
LEU A 374
 None
 0.60A 4wboC-2zv7A:
23.6		 4wboC-2zv7A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 LEU A  29
ALA A  50
MET A 100
LEU A 153
 None
 0.75A 4wboC-3dxnA:
17.4		 4wboC-3dxnA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 LEU A  15
ALA A  36
MET A 117
LEU A 173
 DRK  A 384 (-3.8A)
DRK  A 384 (-3.5A)
DRK  A 384 (-3.8A)
DRK  A 384 (-4.4A)
 0.67A 4wboC-3eb0A:
24.5		 4wboC-3eb0A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  59
ALA A  80
MET A 129
MET A 132
LEU A 186
 STU  A   1 (-3.8A)
STU  A   1 (-3.4A)
STU  A   1 ( 3.8A)
None
STU  A   1 (-4.4A)
 0.55A 4wboC-3fmeA:
21.6		 4wboC-3fmeA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00498
(FHA) 		4 LEU A 226
ALA A 247
MET A 304
LEU A 354
 None
 0.60A 4wboC-3i6uA:
13.7		 4wboC-3i6uA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A  68
ALA A  89
MET A 138
LEU A 191
 ANP  A 522 (-4.6A)
ANP  A 522 (-3.6A)
ANP  A 522 ( 4.4A)
ANP  A 522 (-4.7A)
 0.55A 4wboC-3lijA:
26.5		 4wboC-3lijA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ARG A1003
LEU A1005
ALA A1031
MET A1079
MET A1082
 None
None
None
CCX  A   1 ( 3.9A)
None
 0.61A 4wboC-3lw0A:
22.4		 4wboC-3lw0A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 ARG A  38
LEU A  40
ALA A  61
LEU A 164
 None
DXR  A 299 ( 4.3A)
DXR  A 299 ( 3.9A)
None
 0.86A 4wboC-3ma6A:
21.3		 4wboC-3ma6A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  49
ALA A  70
MET A 120
LEU A 173
 XFE  A 351 (-4.2A)
XFE  A 351 (-3.2A)
XFE  A 351 ( 4.0A)
XFE  A 351 (-4.6A)
 0.70A 4wboC-3mvjA:
33.8		 4wboC-3mvjA:
28.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 LEU A 192
ALA A 213
MET A 266
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
None
AMP  A 577 (-4.8A)
 0.54A 4wboC-3nyoA:
39.7		 4wboC-3nyoA:
44.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 726
ALA A 751
MET A 801
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-3.1A)
None
03Q  A   1 (-4.4A)
 0.68A 4wboC-3pp0A:
23.1		 4wboC-3pp0A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 ARG A  61
LEU A  63
ALA A  84
LEU A 197
 None
ANP  A1634 ( 4.3A)
ANP  A1634 (-3.6A)
ANP  A1634 (-4.4A)
 0.84A 4wboC-3q5iA:
23.8		 4wboC-3q5iA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3she MAP KINASE-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  50
ALA A  71
MET A 118
MET A 121
LEU A 173
 I85  A 350 (-3.7A)
I85  A 350 (-3.3A)
I85  A 350 ( 3.9A)
None
None
 0.59A 4wboC-3sheA:
18.4		 4wboC-3sheA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 361
ALA A 382
MET A 433
LEU A 486
 07U  A   1 ( 4.8A)
07U  A   1 (-3.3A)
07U  A   1 ( 4.3A)
07U  A   1 (-4.3A)
 0.41A 4wboC-3txoA:
30.5		 4wboC-3txoA:
27.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 LEU A 295
ALA A 315
MET A 366
LEU A 423
 None
 0.50A 4wboC-3ulzA:
20.3		 4wboC-3ulzA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ARG A 542
LEU A 544
ALA A 570
MET A 620
LEU A 686
 None
0F4  A 902 ( 4.2A)
0F4  A 902 (-3.2A)
None
0F4  A 902 (-4.5A)
 0.79A 4wboC-3v5qA:
19.9		 4wboC-3v5qA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  59
ALA A  80
MET A 129
MET A 132
 None
ANK  A 401 (-3.0A)
ANK  A 401 (-3.7A)
None
 0.66A 4wboC-3vn9A:
7.3		 4wboC-3vn9A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  59
ALA A  80
MET A 132
LEU A 186
 None
ANK  A 401 (-3.0A)
None
ANK  A 401 ( 4.9A)
 0.86A 4wboC-3vn9A:
7.3		 4wboC-3vn9A:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG A 137
LEU A 139
ALA A 160
LEU A 263
 N13  A 501 ( 4.6A)
N13  A 501 (-3.7A)
N13  A 501 ( 4.1A)
N13  A 501 (-4.5A)
 0.75A 4wboC-3w18A:
22.7		 4wboC-3w18A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A  75
ALA A  96
MET A 144
MET A 147
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 (-3.2A)
CHU  A 403 (-3.8A)
None
ANP  A 401 (-4.8A)
 0.57A 4wboC-3wigA:
23.2		 4wboC-3wigA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A1951
ALA A1978
MET A2029
LEU A2086
 VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
None
VGH  A3000 (-4.3A)
 0.60A 4wboC-3zbfA:
22.6		 4wboC-3zbfA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ARG A 558
LEU A 560
ALA A 586
MET A 636
LEU A 699
 None
LTI  A1839 ( 4.2A)
LTI  A1839 (-3.3A)
None
LTI  A1839 (-4.2A)
 0.77A 4wboC-4at3A:
20.6		 4wboC-4at3A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 ARG A 403
LEU A 539
ALA A 542
MET A 551
LEU A 517
 None
 1.47A 4wboC-4c30A:
undetectable		 4wboC-4c30A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 LEU A  22
ALA A  43
MET A  93
LEU A 146
 STU  A1550 (-4.3A)
STU  A1550 (-3.1A)
STU  A1550 (-3.7A)
STU  A1550 (-4.3A)
 0.70A 4wboC-4cfhA:
29.0		 4wboC-4cfhA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 663
ALA A 684
MET A 737
LEU A 789
 AGS  A1985 (-4.2A)
AGS  A1985 (-3.5A)
AGS  A1985 (-4.2A)
AGS  A1985 (-4.8A)
 0.45A 4wboC-4crsA:
35.1		 4wboC-4crsA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqm PROTEIN KINASE

(Staphylococcus
aureus) 		PF00069
(Pkinase) 		4 LEU A  16
ALA A  37
MET A  87
LEU A 140
 ANP  A 300 (-4.7A)
ANP  A 300 ( 3.8A)
ANP  A 300 (-3.6A)
ANP  A 300 (-4.7A)
 0.58A 4wboC-4eqmA:
23.0		 4wboC-4eqmA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 515
ALA A 541
MET A 591
LEU A 656
 None
 0.64A 4wboC-4f0iA:
16.2		 4wboC-4f0iA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 377
ALA A 400
MET A 448
LEU A 501
 0SB  A 701 ( 3.9A)
0SB  A 701 (-3.3A)
0SB  A 701 (-3.6A)
0SB  A 701 (-4.4A)
 0.67A 4wboC-4f4pA:
23.8		 4wboC-4f4pA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcu 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE

(Acinetobacter
baumannii) 		PF02348
(CTP_transf_3) 		4 ARG A 181
LEU A 183
ALA A 227
LEU A 104
 None
 0.89A 4wboC-4fcuA:
undetectable		 4wboC-4fcuA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fg8 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  26
ALA A  47
MET A  95
LEU A 148
 ATP  A 401 (-3.8A)
ATP  A 401 (-3.6A)
ATP  A 401 ( 4.3A)
ATP  A 401 (-4.6A)
 0.66A 4wboC-4fg8A:
21.6		 4wboC-4fg8A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		4 LEU A 377
ALA A 400
MET A 448
LEU A 501
 ANP  A 701 ( 4.6A)
ANP  A 701 (-3.3A)
ANP  A 701 ( 3.7A)
ANP  A 701 (-4.5A)
 0.47A 4wboC-4fl3A:
21.2		 4wboC-4fl3A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A1122
ALA A1148
MET A1199
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
None
0UV  A1501 (-4.6A)
 0.41A 4wboC-4fodA:
21.7		 4wboC-4fodA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 855
ALA A 880
MET A 929
LEU A 983
 IZA  A2001 (-3.7A)
IZA  A2001 (-3.4A)
IZA  A2001 (-4.4A)
IZA  A2001 ( 4.7A)
 0.54A 4wboC-4gl9A:
23.2		 4wboC-4gl9A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 828
ALA A 853
MET A 902
LEU A 956
 19S  A1201 (-3.9A)
19S  A1201 (-3.3A)
19S  A1201 (-3.6A)
19S  A1201 (-4.5A)
 0.48A 4wboC-4hviA:
23.5		 4wboC-4hviA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrn RHOPTRY KINASE
FAMILY PROTEIN

(Toxoplasma
gondii) 		PF14531
(Kinase-like) 		4 LEU A 258
ALA A 279
MET A 356
LEU A 416
 ANP  A 601 ( 4.6A)
ANP  A 601 ( 3.9A)
ANP  A 601 (-3.3A)
ANP  A 601 ( 4.9A)
 0.69A 4wboC-4jrnA:
18.9		 4wboC-4jrnA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 273
ALA A 293
MET A 341
LEU A 393
 0J9  A 601 (-4.0A)
0J9  A 601 (-3.3A)
None
0J9  A 601 (-4.5A)
 0.49A 4wboC-4k11A:
20.5		 4wboC-4k11A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  33
ALA A  54
MET A  99
LEU A 153
 GOL  A 404 ( 3.6A)
GOL  A 404 ( 3.1A)
GOL  A 403 (-2.7A)
GOL  A 403 ( 4.4A)
 0.51A 4wboC-4lg4A:
25.1		 4wboC-4lg4A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 273
ALA A 293
MET A 341
LEU A 393
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
None
VGG  A 601 (-4.5A)
 0.45A 4wboC-4lggA:
20.0		 4wboC-4lggA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mvf CALCIUM-DEPENDENT
PROTEIN KINASE 2

(Plasmodium
falciparum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 LEU A  78
ALA A  99
MET A 146
LEU A 199
 STU  A 601 ( 4.0A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.3A)
STU  A 601 (-4.7A)
 0.59A 4wboC-4mvfA:
20.7		 4wboC-4mvfA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG A  44
LEU A  46
ALA A  67
LEU A 180
 None
SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
SIN  A 401 ( 4.5A)
 0.68A 4wboC-4o38A:
20.5		 4wboC-4o38A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ARG A 901
LEU A 903
ALA A 928
MET A 978
LEU A1030
 2TT  A1202 ( 4.8A)
2TT  A1202 (-3.5A)
2TT  A1202 ( 3.9A)
2TT  A1202 ( 4.4A)
2TT  A1202 (-4.4A)
 1.02A 4wboC-4oliA:
16.8		 4wboC-4oliA:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		5 ARG A 707
LEU A 708
ALA A 593
MET A 677
LEU A 694
 None
 1.40A 4wboC-4q2cA:
undetectable		 4wboC-4q2cA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		4 ALA A  49
MET A 104
MET A 107
LEU A 156
 ANP  A 402 (-3.3A)
ANP  A 402 (-4.4A)
None
ANP  A 402 (-4.6A)
 0.61A 4wboC-4qnyA:
26.6		 4wboC-4qnyA:
18.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 ARG A 190
LEU A 192
ALA A 213
MET A 266
LEU A 318
 None
SGV  A 601 (-4.1A)
SGV  A 601 (-3.3A)
None
SGV  A 601 (-4.9A)
 0.77A 4wboC-4tnbA:
32.4		 4wboC-4tnbA:
44.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		5 ARG A  12
LEU A  14
ALA A  35
MET A  84
LEU A 136
 None
ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
ACP  A1264 ( 4.8A)
 0.93A 4wboC-4ueuA:
23.6		 4wboC-4ueuA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		4 LEU A 104
ALA A 125
MET A 175
LEU A 228
 ATP  A 501 ( 4.3A)
ATP  A 501 (-3.4A)
ATP  A 501 (-3.6A)
ATP  A 501 (-4.5A)
 0.62A 4wboC-4wb7A:
34.3		 4wboC-4wb7A:
28.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 ARG A 191
ALA A 214
MET A 264
MET A 267
LEU A 321
 ANW  A 601 ( 4.9A)
ANW  A 601 (-3.4A)
ANW  A 601 (-3.2A)
None
ANW  A 601 (-4.9A)
 0.62A 4wboC-4wboA:
38.3		 4wboC-4wboA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		5 LEU A 193
ALA A 214
MET A 264
MET A 267
LEU A 321
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
ANW  A 601 (-3.2A)
None
ANW  A 601 (-4.9A)
 0.18A 4wboC-4wboA:
38.3		 4wboC-4wboA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  52
ALA A  72
MET A 126
LEU A 183
 KSA  A 405 ( 4.0A)
KSA  A 405 (-3.2A)
KSA  A 405 ( 3.7A)
KSA  A 405 (-4.6A)
 0.44A 4wboC-4wsqA:
24.5		 4wboC-4wsqA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 4 LEU B 267
ALA B 288
MET B 337
LEU B 389
 1N1  B 601 (-3.7A)
1N1  B 601 (-3.5A)
None
1N1  B 601 (-4.3A)
 0.60A 4wboC-4xeyB:
22.4		 4wboC-4xeyB:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 408
ALA A 428
MET A 477
LEU A 528
 None
 0.73A 4wboC-4xi2A:
16.4		 4wboC-4xi2A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		4 LEU A 408
ALA A 428
MET A 477
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
None
746  A 702 (-4.4A)
 0.47A 4wboC-4y93A:
21.5		 4wboC-4y93A:
21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4yhj G PROTEIN-COUPLED
RECEPTOR KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 LEU A 193
ALA A 214
MET A 267
LEU A 319
 AN2  A 601 ( 4.2A)
AN2  A 601 (-3.6A)
None
None
 0.37A 4wboC-4yhjA:
44.1		 4wboC-4yhjA:
44.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 ARG A  32
LEU A  34
ALA A  55
LEU A 158
 None
ADP  A 506 ( 3.8A)
ADP  A 506 (-3.3A)
ADP  A 506 (-4.7A)
 0.74A 4wboC-4ysjA:
27.1		 4wboC-4ysjA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zti POLYMERASE COFACTOR
VP35,NUCLEOPROTEIN

(Zaire
ebolavirus) 		PF02097
(Filo_VP35)
PF05505
(Ebola_NP) 		4 ARG A 298
LEU A 244
ALA A 294
LEU A 284
 None
 0.87A 4wboC-4ztiA:
undetectable		 4wboC-4ztiA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		4 ARG A  28
ALA A  51
MET A 106
MET A 109
 None
ANP  A 401 (-3.5A)
ANP  A 401 (-3.8A)
None
 0.81A 4wboC-5awmA:
22.1		 4wboC-5awmA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ARG A 901
LEU A 903
ALA A 928
MET A 978
LEU A1030
 5U3  A1200 ( 4.1A)
5U3  A1200 (-3.8A)
5U3  A1200 (-3.5A)
5U3  A1200 ( 4.0A)
5U3  A1200 (-4.4A)
 1.08A 4wboC-5f1zA:
23.2		 4wboC-5f1zA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5o NUCLEOPROTEIN

(Marburg
marburgvirus) 		PF05505
(Ebola_NP) 		4 ARG A 280
LEU A 226
ALA A 276
LEU A 266
 None
 0.73A 4wboC-5f5oA:
undetectable		 4wboC-5f5oA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 ARG A 597
LEU A 599
ALA A 625
LEU A 825
 None
748  A1001 (-3.8A)
748  A1001 (-3.7A)
748  A1001 (-4.3A)
 0.74A 4wboC-5grnA:
16.5		 4wboC-5grnA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  57
ALA A  77
MET A 130
LEU A 187
 IDV  A 401 (-3.8A)
IDV  A 401 (-3.6A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.71A 4wboC-5i3oA:
23.6		 4wboC-5i3oA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i67 PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Mycobacterium
tuberculosis) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		4 LEU A 443
ALA A 268
MET A 250
MET A 465
 None
 0.80A 4wboC-5i67A:
undetectable		 4wboC-5i67A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		4 LEU A  22
ALA A  43
MET A  93
LEU A 146
 STU  A 601 (-4.1A)
STU  A 601 (-3.3A)
STU  A 601 ( 3.9A)
STU  A 601 (-4.5A)
 0.56A 4wboC-5isoA:
28.1		 4wboC-5isoA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 718
ALA A 743
MET A 793
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
None
6HJ  A1101 ( 4.8A)
 0.43A 4wboC-5j9zA:
22.5		 4wboC-5j9zA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzn SERINE/THREONINE-PRO
TEIN KINASE DCLK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG A 394
ALA A 417
MET A 465
LEU A 518
 None
GUI  A 701 ( 3.9A)
GUI  A 701 ( 4.1A)
GUI  A 701 (-4.4A)
 0.51A 4wboC-5jznA:
26.0		 4wboC-5jznA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 209
ALA A 228
MET A 283
LEU A 338
 None
6UY  A 501 (-3.4A)
6UY  A 501 (-3.8A)
6UY  A 501 (-4.5A)
 0.93A 4wboC-5ko1A:
20.7		 4wboC-5ko1A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 119
MET A 169
MET A 172
LEU A 221
 None
 0.24A 4wboC-5u7qA:
28.9		 4wboC-5u7qA:
27.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 4 LEU A 686
ALA A 707
MET A 754
LEU A 810
 9E1  A1001 (-3.7A)
9E1  A1001 (-3.5A)
9E1  A1001 (-2.8A)
9E1  A1001 (-4.5A)
 0.63A 4wboC-5vilA:
20.9		 4wboC-5vilA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 4 LEU A  24
ALA A  45
MET A  98
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
None
9WS  A 401 (-4.6A)
 0.61A 4wboC-5w5jA:
18.6		 4wboC-5w5jA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 4 ALA A  49
MET A  96
MET A  99
LEU A 150
 VX6  A 402 (-3.2A)
VX6  A 402 (-3.7A)
None
VX6  A 402 (-4.4A)
 0.56A 4wboC-5wnmA:
21.8		 4wboC-5wnmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsq NUCLEOPROTEIN

(Marburg
marburgvirus) 		PF05505
(Ebola_NP) 		4 ARG A 264
LEU A 210
ALA A 260
LEU A 250
 None
 0.92A 4wboC-5xsqA:
undetectable		 4wboC-5xsqA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bx6 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2

(Homo sapiens) 		no annotation 4 LEU A  22
ALA A  43
MET A  93
LEU A 146
 EDJ  A 301 (-3.9A)
EDJ  A 301 (-3.4A)
EDJ  A 301 ( 4.2A)
EDJ  A 301 ( 4.5A)
 0.71A 4wboC-6bx6A:
21.2		 4wboC-6bx6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c54 NUCLEOPROTEIN

(Zaire
ebolavirus) 		no annotation 4 ARG A 298
LEU A 244
ALA A 294
LEU A 284
 None
 0.73A 4wboC-6c54A:
undetectable		 4wboC-6c54A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1

(Homo sapiens) 		no annotation 5 ARG A 879
LEU A 881
ALA A 906
MET A 956
LEU A1010
 None
ADP  A1201 ( 4.5A)
ADP  A1201 (-3.4A)
ADP  A1201 (-4.2A)
ADP  A1201 (-4.5A)
 0.76A 4wboC-6c7yA:
22.5		 4wboC-6c7yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 5 ARG A 195
LEU A 197
ALA A 217
MET A 267
LEU A 319
 None
FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
None
FKY  A9001 ( 4.9A)
 1.05A 4wboC-6cz4A:
21.4		 4wboC-6cz4A:
undetectable