SIMILAR PATTERNS OF AMINO ACIDS FOR 4WA9_B_AXIB9000

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 416
ALA A 428
LYS A 430
THR A 474
MET A 477
GLY A 480
LEU A 528
None
0.79A 4wa9B-1k2pA:
31.4
4wa9B-1k2pA:
45.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 416
ALA A 428
THR A 474
MET A 477
GLY A 480
ASN A 526
LEU A 528
None
0.81A 4wa9B-1k2pA:
31.4
4wa9B-1k2pA:
45.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE


(Rattus
norvegicus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
7 VAL A 209
ALA A 220
LYS A 222
THR A 266
MET A 269
GLY A 272
LEU A 321
None
0.72A 4wa9B-1k9aA:
32.2
4wa9B-1k9aA:
29.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE


(Rattus
norvegicus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
7 VAL A 209
ALA A 220
THR A 266
MET A 269
GLY A 272
ASN A 319
LEU A 321
None
0.60A 4wa9B-1k9aA:
32.2
4wa9B-1k9aA:
29.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK


(Rattus
norvegicus)
PF07714
(Pkinase_Tyr)
8 VAL A 588
ALA A 606
LYS A 608
MET A 657
GLY A 660
ASN A 729
LEU A 731
ALA A 741
None
0.58A 4wa9B-1lufA:
32.4
4wa9B-1lufA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Mus musculus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
8 TYR A 272
VAL A 275
ALA A 288
THR A 334
MET A 337
GLY A 340
LEU A 389
ALA A 399
P16  A   2 (-3.6A)
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-3.7A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.79A 4wa9B-1opkA:
37.8
4wa9B-1opkA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Mus musculus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
10 VAL A 275
ALA A 288
LYS A 290
THR A 334
PHE A 336
MET A 337
GLY A 340
ASN A 387
LEU A 389
ALA A 399
P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-3.7A)
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
0.54A 4wa9B-1opkA:
37.8
4wa9B-1opkA:
57.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ac5 MAP
KINASE-INTERACTING
SERINE/THREONINE
KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
7 VAL A  98
ALA A 111
LYS A 113
MET A 162
GLY A 165
ASN A 210
LEU A 212
None
0.75A 4wa9B-2ac5A:
20.4
4wa9B-2ac5A:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16


(Homo sapiens)
PF00069
(Pkinase)
7 VAL A  34
ALA A  47
LYS A  49
PHE A 100
GLY A 104
ASN A 153
LEU A 155
STU  A1301 (-4.8A)
STU  A1301 (-3.6A)
STU  A1301 ( 4.0A)
STU  A1301 (-4.5A)
STU  A1301 ( 4.0A)
None
STU  A1301 ( 4.8A)
0.71A 4wa9B-2bujA:
24.2
4wa9B-2bujA:
23.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 VAL X  25
ALA X  37
LYS X  39
THR X  82
MET X  85
GLY X  88
LEU X 137
ALA X 147
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 (-4.1A)
None
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
0.71A 4wa9B-2dq7X:
35.4
4wa9B-2dq7X:
45.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 VAL X  25
ALA X  37
THR X  82
MET X  85
GLY X  88
ASN X 135
LEU X 137
ALA X 147
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-4.1A)
None
STU  X 902 (-3.5A)
STU  X 902 ( 4.9A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
0.50A 4wa9B-2dq7X:
35.4
4wa9B-2dq7X:
45.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
8 VAL A 281
ALA A 293
THR A 338
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
None
H8H  A 534 (-3.3A)
H8H  A 534 ( 4.9A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
0.80A 4wa9B-2h8hA:
30.4
4wa9B-2h8hA:
27.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
8 ALA A 293
THR A 338
PHE A 340
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
None
QUE  A   1 (-3.0A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
0.58A 4wa9B-2hckA:
30.4
4wa9B-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
8 VAL A 281
ALA A 293
LYS A 295
THR A 338
PHE A 340
MET A 341
LEU A 393
ALA A 403
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
1.17A 4wa9B-2hckA:
30.4
4wa9B-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
8 VAL A 281
ALA A 293
THR A 338
PHE A 340
MET A 341
ASN A 391
LEU A 393
ALA A 403
QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
QUE  A   1 (-4.2A)
None
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
0.85A 4wa9B-2hckA:
30.4
4wa9B-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2


(Mus musculus)
PF07714
(Pkinase_Tyr)
7 VAL A 643
ALA A 659
THR A 707
MET A 710
GLY A 713
ASN A 759
LEU A 761
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.2A)
MG  A 404 (-4.5A)
ADP  A 400 ( 4.7A)
0.92A 4wa9B-2henA:
31.4
4wa9B-2henA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2


(Mus musculus)
PF07714
(Pkinase_Tyr)
7 VAL A 643
ALA A 659
THR A 707
PHE A 709
MET A 710
GLY A 713
LEU A 761
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-4.7A)
None
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
0.72A 4wa9B-2henA:
31.4
4wa9B-2henA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 VAL A 259
ALA A 271
LYS A 273
THR A 316
PHE A 318
MET A 319
GLY A 322
LEU A 371
ALA A 381
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
0.79A 4wa9B-2hk5A:
35.2
4wa9B-2hk5A:
46.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 VAL A 259
ALA A 271
THR A 316
PHE A 318
MET A 319
GLY A 322
ASN A 369
LEU A 371
ALA A 381
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.1A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
0.69A 4wa9B-2hk5A:
35.2
4wa9B-2hk5A:
46.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 VAL A 256
ALA A 269
LYS A 271
THR A 315
PHE A 317
MET A 318
GLY A 321
LEU A 370
ALA A 380
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
0.63A 4wa9B-2hz0A:
34.9
4wa9B-2hz0A:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 VAL A 256
ALA A 269
THR A 315
PHE A 317
MET A 318
GLY A 321
ASN A 368
LEU A 370
ALA A 380
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.3A)
None
None
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
0.64A 4wa9B-2hz0A:
34.9
4wa9B-2hz0A:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 VAL A 259
ALA A 271
LYS A 273
THR A 316
MET A 319
GLY A 322
LEU A 371
ALA A 381
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
0.78A 4wa9B-2og8A:
31.4
4wa9B-2og8A:
45.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 VAL A 259
ALA A 271
THR A 316
MET A 319
GLY A 322
ASN A 369
LEU A 371
ALA A 381
None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 3.5A)
None
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
0.70A 4wa9B-2og8A:
31.4
4wa9B-2og8A:
45.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB


(Homo sapiens)
PF00069
(Pkinase)
7 VAL A 204
ALA A 215
LYS A 217
THR A 265
PHE A 267
LEU A 328
ALA A 338
ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 (-4.4A)
None
0.96A 4wa9B-2qluA:
26.2
4wa9B-2qluA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB


(Homo sapiens)
PF00069
(Pkinase)
8 VAL A 204
ALA A 215
THR A 265
PHE A 267
GLY A 271
ASN A 326
LEU A 328
ALA A 338
ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
None
0.74A 4wa9B-2qluA:
26.2
4wa9B-2qluA:
25.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 635
ALA A 651
THR A 699
MET A 702
GLY A 705
ASN A 751
LEU A 753
BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
None
0.77A 4wa9B-2qobA:
32.1
4wa9B-2qobA:
34.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
7 VAL A 689
ALA A 705
THR A 753
MET A 756
GLY A 759
ASN A 805
LEU A 807
None
0.58A 4wa9B-2r2pA:
34.8
4wa9B-2r2pA:
37.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25


(Homo sapiens)
PF00069
(Pkinase)
7 VAL A  34
ALA A  47
LYS A  49
GLY A 101
ASN A 145
LEU A 147
ALA A 157
J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
J60  A1294 ( 3.8A)
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
0.98A 4wa9B-2xikA:
20.5
4wa9B-2xikA:
27.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,


(Mus musculus)
PF07714
(Pkinase_Tyr)
8 VAL A 635
ALA A 651
LYS A 653
THR A 699
MET A 702
GLY A 705
ASN A 751
LEU A 753
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.5A)
None
Q9G  A1898 ( 3.8A)
None
Q9G  A1898 (-4.3A)
0.77A 4wa9B-2xyuA:
32.4
4wa9B-2xyuA:
38.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM


(Homo sapiens)
PF00069
(Pkinase)
7 VAL A  38
ALA A  51
LYS A  53
MET A 110
GLY A 113
ASN A 158
LEU A 160
None
B49  A1294 (-3.2A)
None
None
B49  A1294 (-3.6A)
None
B49  A1294 (-4.4A)
0.90A 4wa9B-2y7jA:
25.4
4wa9B-2y7jA:
26.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN


(Mus musculus)
PF07714
(Pkinase_Tyr)
7 VAL A 261
ALA A 273
LYS A 275
THR A 319
PHE A 321
MET A 322
ALA A 384
None
0.84A 4wa9B-2zv7A:
32.6
4wa9B-2zv7A:
45.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN


(Mus musculus)
PF07714
(Pkinase_Tyr)
9 VAL A 261
ALA A 273
THR A 319
PHE A 321
MET A 322
GLY A 325
ASN A 372
LEU A 374
ALA A 384
None
0.81A 4wa9B-2zv7A:
32.6
4wa9B-2zv7A:
45.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 495
ALA A 515
LYS A 517
GLY A 570
ASN A 631
LEU A 633
ALA A 643
M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
M33  A1996 ( 4.8A)
None
M33  A1996 (-4.5A)
None
0.86A 4wa9B-3b2tA:
33.4
4wa9B-3b2tA:
40.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK


(Homo sapiens)
PF00069
(Pkinase)
7 VAL A  26
ALA A  39
LYS A  41
PHE A  93
MET A  94
GLY A  96
LEU A 148
3AM  A 338 ( 4.1A)
3AM  A 338 (-3.3A)
3AM  A 338 (-2.9A)
3AM  A 338 ( 4.6A)
None
None
3AM  A 338 (-4.7A)
0.89A 4wa9B-3c0iA:
25.5
4wa9B-3c0iA:
25.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 209
ALA A 220
LYS A 222
THR A 266
MET A 269
GLY A 272
LEU A 321
None
0.72A 4wa9B-3d7uA:
27.5
4wa9B-3d7uA:
44.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 209
ALA A 220
THR A 266
MET A 269
GLY A 272
ASN A 319
LEU A 321
None
0.60A 4wa9B-3d7uA:
27.5
4wa9B-3d7uA:
44.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
8 VAL A 647
ALA A 663
LYS A 665
PHE A 713
MET A 714
GLY A 717
ASN A 763
LEU A 765
IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
None
None
IHZ  A1001 ( 3.9A)
None
IHZ  A1001 (-4.6A)
0.92A 4wa9B-3dkoA:
30.7
4wa9B-3dkoA:
36.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 158
ALA A 169
LYS A 171
PHE A 222
GLY A 226
ASN A 273
LEU A 275
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
None
VIN  A6331 ( 4.8A)
VIN  A6331 (-3.4A)
VIN  A6331 ( 4.8A)
VIN  A6331 (-4.5A)
0.72A 4wa9B-3dtcA:
27.3
4wa9B-3dtcA:
34.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2


(Homo sapiens)
PF00069
(Pkinase)
PF00627
(UBA)
7 VAL A  67
ALA A  80
LYS A  82
GLY A 135
ASN A 180
LEU A 182
ALA A 192
None
0.88A 4wa9B-3iecA:
24.5
4wa9B-3iecA:
25.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
7 VAL A 649
ALA A 665
LYS A 667
THR A 713
MET A 716
GLY A 719
LEU A 767
None
None
None
None
None
GOL  A 403 (-3.4A)
None
0.69A 4wa9B-3kulA:
34.8
4wa9B-3kulA:
34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
7 VAL A 649
ALA A 665
THR A 713
MET A 716
GLY A 719
ASN A 765
LEU A 767
None
None
None
None
GOL  A 403 (-3.4A)
None
None
0.63A 4wa9B-3kulA:
34.8
4wa9B-3kulA:
34.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS)
7 VAL A 218
ALA A 229
LYS A 231
THR A 279
GLY A 285
LEU A 339
ALA A 349
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
0.83A 4wa9B-3mdyA:
26.7
4wa9B-3mdyA:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 216
ALA A 227
THR A 277
GLY A 283
ASN A 335
LEU A 337
ALA A 347
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.5A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
0.80A 4wa9B-3my0A:
25.6
4wa9B-3my0A:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN


(Cryptosporidium
parvum)
PF00069
(Pkinase)
7 VAL A  37
ALA A  49
PHE A 100
MET A 101
ASN A 149
LEU A 151
ALA A 161
ADP  A 314 (-4.0A)
ADP  A 314 (-3.5A)
ADP  A 314 ( 4.3A)
None
MG  A 312 ( 2.9A)
ADP  A 314 (-4.6A)
None
0.66A 4wa9B-3nizA:
24.0
4wa9B-3nizA:
26.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 734
ALA A 751
THR A 798
MET A 801
GLY A 804
ASN A 850
LEU A 852
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.2A)
03Q  A   1 (-4.4A)
0.76A 4wa9B-3pp0A:
32.4
4wa9B-3pp0A:
35.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A 217
THR A 267
PHE A 269
GLY A 273
ASN A 327
LEU A 329
ALA A 339
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-4.3A)
TAK  A   2 (-3.6A)
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
0.65A 4wa9B-3q4tA:
25.5
4wa9B-3q4tA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A


(Homo sapiens)
PF00069
(Pkinase)
7 VAL A 206
ALA A 217
THR A 267
GLY A 273
ASN A 327
LEU A 329
ALA A 339
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
0.70A 4wa9B-3q4tA:
25.5
4wa9B-3q4tA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
7 VAL A  71
ALA A  84
LYS A  86
THR A 144
PHE A 146
GLY A 150
LEU A 197
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
ANP  A1634 (-4.4A)
0.68A 4wa9B-3q5iA:
22.2
4wa9B-3q5iA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
7 VAL A  71
ALA A  84
THR A 144
PHE A 146
GLY A 150
ASN A 195
LEU A 197
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-4.6A)
ANP  A1634 (-4.8A)
None
CA  A 528 ( 3.0A)
ANP  A1634 (-4.4A)
0.69A 4wa9B-3q5iA:
22.2
4wa9B-3q5iA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 492
ALA A 512
LYS A 514
GLY A 567
ASN A 628
LEU A 630
ALA A 640
07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.7A)
None
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
0.85A 4wa9B-3tt0A:
31.1
4wa9B-3tt0A:
38.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
7 VAL A 369
ALA A 382
LYS A 384
PHE A 435
GLY A 439
LEU A 486
ALA A 496
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
0.77A 4wa9B-3txoA:
13.8
4wa9B-3txoA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
7 VAL A 369
ALA A 382
PHE A 435
GLY A 439
ASN A 484
LEU A 486
ALA A 496
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
None
None
None
07U  A   1 (-4.3A)
07U  A   1 ( 4.0A)
0.78A 4wa9B-3txoA:
13.8
4wa9B-3txoA:
25.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 848
ALA A 866
LYS A 868
PHE A 918
GLY A 922
ASN A1033
LEU A1035
4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
4TT  A2001 (-4.5A)
4TT  A2001 (-3.7A)
None
4TT  A2001 (-4.8A)
0.75A 4wa9B-3vidA:
30.3
4wa9B-3vidA:
34.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 848
ALA A 866
LYS A 868
PHE A 918
GLY A 922
ASN A1033
LEU A1035
LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-4.7A)
LEV  A1201 (-3.6A)
GOL  A1210 (-3.6A)
LEV  A1201 (-4.8A)
0.87A 4wa9B-3wzdA:
32.3
4wa9B-3wzdA:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A1959
ALA A1978
LYS A1980
MET A2029
GLY A2032
ASN A2084
LEU A2086
None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
VGH  A3000 (-3.5A)
None
VGH  A3000 (-4.3A)
0.99A 4wa9B-3zbfA:
26.6
4wa9B-3zbfA:
40.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 VAL A 633
ALA A 649
THR A 697
PHE A 699
MET A 700
GLY A 703
ASN A 749
LEU A 751
None
0.64A 4wa9B-3zfxA:
33.3
4wa9B-3zfxA:
41.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 105
ALA A 121
LYS A 123
THR A 169
PHE A 171
MET A 172
ASN A 221
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
None
30K  A1365 (-4.4A)
0.93A 4wa9B-4aw5A:
32.4
4wa9B-4aw5A:
38.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
8 VAL A 105
ALA A 121
THR A 169
PHE A 171
MET A 172
GLY A 175
ASN A 221
LEU A 223
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-4.4A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.4A)
30K  A1365 (-4.5A)
0.67A 4wa9B-4aw5A:
32.4
4wa9B-4aw5A:
38.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10


(Homo sapiens)
PF00069
(Pkinase)
8 VAL A  50
ALA A  63
LYS A  65
PHE A 112
GLY A 116
ASN A 162
LEU A 164
ALA A 174
XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-4.1A)
XZN  A1317 (-4.5A)
XZN  A1317 ( 3.7A)
None
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
1.13A 4wa9B-4bc6A:
22.2
4wa9B-4bc6A:
29.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1


(Homo sapiens)
PF00069
(Pkinase)
PF08515
(TGF_beta_GS)
7 VAL A 222
ALA A 233
THR A 283
GLY A 289
ASN A 341
LEU A 343
ALA A 353
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
0.74A 4wa9B-4c02A:
26.0
4wa9B-4c02A:
27.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
9 VAL A 624
ALA A 653
LYS A 655
THR A 701
MET A 704
GLY A 707
ASN A 771
LEU A 773
ALA A 783
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.6A)
None
None
None
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
0.71A 4wa9B-4ckrA:
29.8
4wa9B-4ckrA:
37.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 523
ALA A 541
LYS A 543
MET A 591
GLY A 594
ASN A 654
LEU A 656
None
0.70A 4wa9B-4f0iA:
24.6
4wa9B-4f0iA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Homo sapiens)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
7 VAL A 281
ALA A 293
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
None
0J9  A 601 ( 4.1A)
None
0J9  A 601 (-4.5A)
0J9  A 601 (-3.5A)
0.79A 4wa9B-4k11A:
30.5
4wa9B-4k11A:
35.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC


(Gallus gallus)
PF07714
(Pkinase_Tyr)
7 VAL A 281
ALA A 293
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
None
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
0.77A 4wa9B-4lggA:
29.9
4wa9B-4lggA:
46.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3


(Mus musculus)
PF00069
(Pkinase)
7 ALA A  49
THR A  95
PHE A  97
MET A  98
GLY A 101
LEU A 150
ALA A 160
ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
ANP  A 401 (-3.8A)
None
None
ANP  A 401 (-4.8A)
None
0.85A 4wa9B-4m69A:
24.4
4wa9B-4m69A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3


(Mus musculus)
PF00069
(Pkinase)
7 VAL A  36
ALA A  49
THR A  95
MET A  98
GLY A 101
LEU A 150
ALA A 160
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
None
None
ANP  A 401 (-4.8A)
None
0.78A 4wa9B-4m69A:
24.4
4wa9B-4m69A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE


(Homo sapiens)
PF00069
(Pkinase)
7 VAL A  54
ALA A  67
LYS A  69
THR A 123
GLY A 128
ASN A 178
LEU A 180
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
0.71A 4wa9B-4o38A:
20.7
4wa9B-4o38A:
25.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
7 VAL A 627
ALA A 644
THR A 692
MET A 695
GLY A 698
ASN A 744
LEU A 746
None
0.85A 4wa9B-4p2kA:
32.6
4wa9B-4p2kA:
38.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL


(synthetic
construct)
PF07714
(Pkinase_Tyr)
7 VAL A  22
ALA A  35
LYS A  37
THR A  81
MET A  84
LEU A 136
ALA A 146
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
None
ACP  A1264 ( 4.8A)
None
0.82A 4wa9B-4ueuA:
33.7
4wa9B-4ueuA:
64.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL


(synthetic
construct)
PF07714
(Pkinase_Tyr)
8 VAL A  22
ALA A  35
THR A  81
MET A  84
GLY A  87
ASN A 134
LEU A 136
ALA A 146
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
ACP  A1264 (-4.5A)
None
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
None
0.65A 4wa9B-4ueuA:
33.7
4wa9B-4ueuA:
64.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
7 ALA A  61
PHE A 110
GLY A 114
ASN A 160
LEU A 162
ALA A 172
PHE A 174
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
None
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
1.31A 4wa9B-4usfA:
18.0
4wa9B-4usfA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
7 VAL A  48
ALA A  61
PHE A 110
GLY A 114
ASN A 160
LEU A 162
ALA A 172
None
6UI  A 700 (-3.3A)
6UI  A 700 (-4.3A)
6UI  A 700 ( 4.2A)
None
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
1.04A 4wa9B-4usfA:
18.0
4wa9B-4usfA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
7 VAL A  60
ALA A  72
LYS A  74
PHE A 128
GLY A 132
ASN A 181
LEU A 183
KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
KSA  A 405 (-4.8A)
KSA  A 405 (-3.5A)
KSA  A 405 (-4.0A)
KSA  A 405 (-4.6A)
0.78A 4wa9B-4wsqA:
24.0
4wa9B-4wsqA:
24.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 481
ALA A 501
LYS A 503
GLY A 556
ASN A 617
LEU A 619
ALA A 629
40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 ( 3.7A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
0.93A 4wa9B-4xcuA:
31.5
4wa9B-4xcuA:
40.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
no annotation 9 VAL B 275
ALA B 288
THR B 334
PHE B 336
MET B 337
GLY B 340
ASN B 387
LEU B 389
ALA B 399
1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-3.3A)
1N1  B 601 ( 4.2A)
None
1N1  B 601 (-3.5A)
None
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
0.48A 4wa9B-4xeyB:
40.8
4wa9B-4xeyB:
78.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1


(Homo sapiens)
no annotation 9 VAL B 275
ALA B 288
THR B 334
PHE B 336
MET B 337
GLY B 340
LEU B 389
ALA B 399
PHE B 401
1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-3.3A)
1N1  B 601 ( 4.2A)
None
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
None
1.09A 4wa9B-4xeyB:
40.8
4wa9B-4xeyB:
78.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE


(Bos taurus)
PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr)
7 VAL A 416
ALA A 428
THR A 474
MET A 477
GLY A 480
ASN A 526
LEU A 528
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-2.8A)
746  A 702 (-4.4A)
0.56A 4wa9B-4y93A:
30.8
4wa9B-4y93A:
29.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 477
ALA A 488
LYS A 490
THR A 539
GLY A 545
LEU A 595
ALA A 605
None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
4CV  A 801 (-2.8A)
4CV  A 801 ( 4.0A)
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
0.72A 4wa9B-4yffA:
26.3
4wa9B-4yffA:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 258
ALA A 275
LYS A 277
THR A 325
PHE A 327
GLY A 331
LEU A 386
STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.4A)
STU  A 601 (-3.5A)
STU  A 601 (-3.9A)
0.86A 4wa9B-5e8yA:
19.8
4wa9B-5e8yA:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 258
ALA A 275
THR A 325
PHE A 327
GLY A 331
ASN A 384
LEU A 386
STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.4A)
STU  A 601 (-3.5A)
STU  A 601 ( 4.9A)
STU  A 601 (-3.9A)
0.63A 4wa9B-5e8yA:
19.8
4wa9B-5e8yA:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iso 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-2


(Homo sapiens)
PF00069
(Pkinase)
PF16579
(AdenylateSensor)
7 VAL A  30
ALA A  43
LYS A  45
GLY A  99
ASN A 144
LEU A 146
ALA A 156
STU  A 601 (-4.8A)
STU  A 601 (-3.3A)
STU  A 601 ( 4.4A)
STU  A 601 ( 4.0A)
STU  A 601 (-4.3A)
STU  A 601 (-4.5A)
STU  A 601 (-3.5A)
0.77A 4wa9B-5isoA:
25.1
4wa9B-5isoA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3


(Homo sapiens)
PF00069
(Pkinase)
7 VAL A  30
ALA A  43
LYS A  45
PHE A  92
GLY A  96
LEU A 143
ALA A 153
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
0.69A 4wa9B-5j5tA:
22.1
4wa9B-5j5tA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3


(Homo sapiens)
PF00069
(Pkinase)
7 VAL A  30
ALA A  43
PHE A  92
GLY A  96
ASN A 141
LEU A 143
ALA A 153
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 (-4.1A)
6G2  A 901 (-3.6A)
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
0.62A 4wa9B-5j5tA:
22.1
4wa9B-5j5tA:
24.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ALA A 663
THR A 711
PHE A 713
MET A 714
ASN A 763
LEU A 765
PHE A 777
6P6  A1001 (-3.3A)
6P6  A1001 (-3.5A)
6P6  A1001 ( 4.5A)
None
None
6P6  A1001 (-4.5A)
DIO  A1002 (-4.5A)
1.30A 4wa9B-5l6oA:
31.4
4wa9B-5l6oA:
38.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 647
ALA A 663
LYS A 665
PHE A 713
MET A 714
ASN A 763
LEU A 765
None
6P6  A1001 (-3.3A)
None
6P6  A1001 ( 4.5A)
None
None
6P6  A1001 (-4.5A)
0.78A 4wa9B-5l6oA:
31.4
4wa9B-5l6oA:
38.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 647
ALA A 663
THR A 711
PHE A 713
MET A 714
ASN A 763
LEU A 765
None
6P6  A1001 (-3.3A)
6P6  A1001 (-3.5A)
6P6  A1001 ( 4.5A)
None
None
6P6  A1001 (-4.5A)
0.62A 4wa9B-5l6oA:
31.4
4wa9B-5l6oA:
38.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1


(Arabidopsis
thaliana)
PF00069
(Pkinase)
7 VAL A 897
ALA A 909
LYS A 911
PHE A 958
MET A 959
GLY A 962
LEU A1016
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
ATP  A1200 ( 4.0A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
0.63A 4wa9B-5lpyA:
24.7
4wa9B-5lpyA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1


(Arabidopsis
thaliana)
PF00069
(Pkinase)
7 VAL A 897
ALA A 909
PHE A 958
MET A 959
GLY A 962
ASN A1014
LEU A1016
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 ( 4.0A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-3.6A)
ATP  A1200 (-4.6A)
0.53A 4wa9B-5lpyA:
24.7
4wa9B-5lpyA:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1


(Arabidopsis
thaliana)
PF00069
(Pkinase)
7 VAL A 897
ALA A 909
PHE A 958
MET A 959
GLY A 962
ASN A1014
LEU A1016
ADP  A1200 (-4.4A)
ADP  A1200 (-3.5A)
ADP  A1200 (-4.1A)
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-3.6A)
ADP  A1200 (-4.7A)
0.46A 4wa9B-5lpzA:
24.8
4wa9B-5lpzA:
29.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5td2 TYROSINE-PROTEIN
KINASE MER


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 601
ALA A 617
PHE A 673
MET A 674
GLY A 677
ASN A 728
ALA A 740
7AE  A1000 ( 4.9A)
7AE  A1000 (-3.3A)
7AE  A1000 (-4.1A)
None
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.7A)
7AE  A1000 ( 3.7A)
0.61A 4wa9B-5td2A:
29.0
4wa9B-5td2A:
42.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1


(Arabidopsis
thaliana)
no annotation 7 VAL A  81
ALA A 103
LYS A 105
MET A 153
GLY A 156
ASN A 207
LEU A 209
None
1.09A 4wa9B-5tosA:
18.2
4wa9B-5tosA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1


(Arabidopsis
thaliana)
no annotation 7 VAL A  81
ALA A 103
PHE A 152
MET A 153
GLY A 156
ASN A 207
LEU A 209
None
0.78A 4wa9B-5tosA:
18.2
4wa9B-5tosA:
12.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 550
ALA A 565
LYS A 567
PHE A 622
MET A 623
GLY A 626
ALA A 689
7YS  A9001 (-4.2A)
7YS  A9001 (-3.3A)
None
7YS  A9001 (-4.3A)
7YS  A9001 (-4.7A)
7YS  A9001 (-3.4A)
7YS  A9001 (-3.4A)
0.77A 4wa9B-5u6bA:
30.2
4wa9B-5u6bA:
43.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A 550
ALA A 565
PHE A 622
MET A 623
GLY A 626
ASN A 677
ALA A 689
7YS  A9001 (-4.2A)
7YS  A9001 (-3.3A)
7YS  A9001 (-4.3A)
7YS  A9001 (-4.7A)
7YS  A9001 (-3.4A)
None
7YS  A9001 (-3.4A)
0.78A 4wa9B-5u6bA:
30.2
4wa9B-5u6bA:
43.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2


(Homo sapiens)
no annotation 8 VAL A  32
ALA A  45
THR A  95
MET A  98
GLY A 101
ASN A 151
LEU A 153
ALA A 163
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
None
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
0.64A 4wa9B-5w5jA:
24.2
4wa9B-5w5jA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzw SERINE/THREONINE-PRO
TEIN KINASE RAD53


(Saccharomyces
cerevisiae)
no annotation 7 VAL A 212
ALA A 225
LYS A 227
PHE A 275
GLY A 279
ASN A 324
LEU A 326
None
0.88A 4wa9B-5xzwA:
19.3
4wa9B-5xzwA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2


(Homo sapiens)
no annotation 7 VAL A 179
ALA A 192
LYS A 194
GLY A 273
ASN A 317
LEU A 319
ALA A 329
F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
F6J  A 501 (-2.9A)
F6J  A 501 ( 3.7A)
F6J  A 501 ( 4.7A)
F6J  A 501 (-4.5A)
F6J  A 501 ( 4.0A)
0.73A 4wa9B-6cmjA:
24.4
4wa9B-6cmjA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6


(Homo sapiens)
no annotation 7 VAL A 205
ALA A 217
THR A 264
MET A 267
GLY A 270
ASN A 317
LEU A 319
FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
FKY  A9001 (-3.0A)
None
FKY  A9001 (-3.3A)
None
FKY  A9001 ( 4.9A)
0.94A 4wa9B-6cz4A:
29.3
4wa9B-6cz4A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-)
no annotation 7 VAL U  28
ALA U  42
LYS U  44
PHE U  93
GLY U  97
LEU U 144
ALA U 156
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.0A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
0.98A 4wa9B-6fdyU:
23.8
4wa9B-6fdyU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-)
no annotation 7 VAL U  28
ALA U  42
PHE U  93
GLY U  97
ASN U 142
LEU U 144
ALA U 156
DB8  U 301 ( 4.8A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.4A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.5A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
0.82A 4wa9B-6fdyU:
23.8
4wa9B-6fdyU:
undetectable