SIMILAR PATTERNS OF AMINO ACIDS FOR 4WA9_A_AXIA9000

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 428
THR A 474
MET A 477
GLY A 480
ASN A 526
LEU A 528
 None
 0.46A 4wa9A-1k2pA:
29.8		 4wa9A-1k2pA:
45.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 ALA A 220
THR A 266
MET A 269
GLY A 272
ASN A 319
LEU A 321
 None
 0.33A 4wa9A-1k9aA:
29.0		 4wa9A-1k9aA:
29.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 606
MET A 657
GLY A 660
ASN A 729
LEU A 731
ALA A 741
 None
 0.48A 4wa9A-1lufA:
28.4		 4wa9A-1lufA:
36.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ALA A 288
THR A 334
MET A 337
GLY A 340
ASN A 387
LEU A 389
ALA A 399
 P16  A   2 (-3.4A)
P16  A   2 (-3.7A)
None
P16  A   2 (-3.4A)
None
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.52A 4wa9A-1opkA:
33.1		 4wa9A-1opkA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 267
ALA A 288
LYS A 290
THR A 334
MET A 337
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-3.7A)
None
P16  A   2 (-4.4A)
 1.01A 4wa9A-1opkA:
33.1		 4wa9A-1opkA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 267
ALA A 288
THR A 334
MET A 337
GLY A 340
LEU A 389
 P16  A   2 ( 4.2A)
P16  A   2 (-3.4A)
P16  A   2 (-3.7A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.84A 4wa9A-1opkA:
33.1		 4wa9A-1opkA:
57.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 TYR A 272
ALA A 288
THR A 334
MET A 337
GLY A 340
LEU A 389
ALA A 399
 P16  A   2 (-3.6A)
P16  A   2 (-3.4A)
P16  A   2 (-3.7A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.85A 4wa9A-1opkA:
33.1		 4wa9A-1opkA:
57.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  78
ALA A  99
LYS A 101
MET A 150
GLY A 153
LEU A 201
 ATP  A 535 (-3.9A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 2.5A)
None
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
 0.94A 4wa9A-1s9iA:
20.4		 4wa9A-1s9iA:
24.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 389
LYS A 391
MET A 438
GLY A 441
ASN A 487
LEU A 489
 None
 0.99A 4wa9A-1snxA:
27.8		 4wa9A-1snxA:
40.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA X  37
THR X  82
MET X  85
GLY X  88
ASN X 135
LEU X 137
ALA X 147
 STU  X 902 (-3.1A)
STU  X 902 (-4.1A)
None
STU  X 902 (-3.5A)
STU  X 902 ( 4.9A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.54A 4wa9A-2dq7X:
31.6		 4wa9A-2dq7X:
45.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU X  17
ALA X  37
LYS X  39
THR X  82
MET X  85
GLY X  88
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 (-4.1A)
None
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 1.21A 4wa9A-2dq7X:
31.6		 4wa9A-2dq7X:
45.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU X  17
ALA X  37
THR X  82
MET X  85
GLY X  88
ASN X 135
LEU X 137
 STU  X 902 (-3.8A)
STU  X 902 (-3.1A)
STU  X 902 (-4.1A)
None
STU  X 902 (-3.5A)
STU  X 902 ( 4.9A)
STU  X 902 (-4.4A)
 0.80A 4wa9A-2dq7X:
31.6		 4wa9A-2dq7X:
45.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ALA A 293
THR A 338
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
None
H8H  A 534 (-3.3A)
H8H  A 534 ( 4.9A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.57A 4wa9A-2h8hA:
28.7		 4wa9A-2h8hA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
ALA A 293
LYS A 295
THR A 338
MET A 341
GLY A 344
LEU A 393
 H8H  A 534 (-3.8A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.1A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.79A 4wa9A-2h8hA:
28.7		 4wa9A-2h8hA:
27.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 ALA A 293
THR A 338
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
None
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.51A 4wa9A-2hckA:
28.2		 4wa9A-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
ALA A 293
LYS A 295
THR A 338
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.71A 4wa9A-2hckA:
28.2		 4wa9A-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
ALA A 293
THR A 338
MET A 341
GLY A 344
ASN A 391
LEU A 393
 QUE  A   1 (-3.9A)
QUE  A   1 (-3.5A)
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
None
QUE  A   1 (-4.4A)
 0.65A 4wa9A-2hckA:
28.2		 4wa9A-2hckA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 ALA A 659
THR A 707
MET A 710
GLY A 713
ASN A 759
LEU A 761
 ADP  A 400 (-3.2A)
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.2A)
MG  A 404 (-4.5A)
ADP  A 400 ( 4.7A)
 0.59A 4wa9A-2henA:
28.4		 4wa9A-2henA:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 271
LYS A 273
THR A 316
MET A 319
GLY A 322
ASN A 369
LEU A 371
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
 1.10A 4wa9A-2hk5A:
31.9		 4wa9A-2hk5A:
46.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 251
ALA A 271
THR A 316
MET A 319
GLY A 322
ASN A 369
LEU A 371
ALA A 381
 1BM  A 499 ( 3.7A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.1A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.45A 4wa9A-2hk5A:
31.9		 4wa9A-2hk5A:
46.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 269
THR A 315
MET A 318
GLY A 321
ASN A 368
LEU A 370
ALA A 380
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.4A)
None
None
None
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.63A 4wa9A-2hz0A:
31.1		 4wa9A-2hz0A:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 248
ALA A 269
THR A 315
MET A 318
GLY A 321
LEU A 370
 GIN  A 600 ( 4.6A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.4A)
None
None
GIN  A 600 (-4.7A)
 0.71A 4wa9A-2hz0A:
31.1		 4wa9A-2hz0A:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 271
THR A 316
MET A 319
GLY A 322
ASN A 369
LEU A 371
ALA A 381
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 3.5A)
None
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
 0.64A 4wa9A-2og8A:
27.8		 4wa9A-2og8A:
45.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 251
ALA A 271
THR A 316
MET A 319
GLY A 322
LEU A 371
ALA A 381
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
 0.86A 4wa9A-2og8A:
27.8		 4wa9A-2og8A:
45.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 588
ALA A 614
THR A 663
GLY A 669
ASN A 783
LEU A 785
 None
 0.78A 4wa9A-2ogvA:
26.0		 4wa9A-2ogvA:
37.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 LEU A  25
ALA A  46
MET A 106
GLY A 109
ASN A 154
LEU A 156
 ATP  A 381 ( 4.3A)
ATP  A 381 (-3.5A)
None
None
MN  A 383 ( 2.7A)
ATP  A 381 ( 4.8A)
 0.77A 4wa9A-2phkA:
21.1		 4wa9A-2phkA:
28.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 215
THR A 265
GLY A 271
ASN A 326
LEU A 328
ALA A 338
 ADE  A 488 (-3.2A)
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
None
ADE  A 488 (-4.4A)
None
 0.58A 4wa9A-2qluA:
23.6		 4wa9A-2qluA:
25.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 651
THR A 699
MET A 702
GLY A 705
ASN A 751
LEU A 753
 PTR  A 701 ( 4.7A)
None
PTR  A 701 ( 3.5A)
None
None
None
 0.30A 4wa9A-2qobA:
29.0		 4wa9A-2qobA:
34.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ALA A 705
THR A 753
MET A 756
GLY A 759
ASN A 805
LEU A 807
 None
 0.33A 4wa9A-2r2pA:
31.2		 4wa9A-2r2pA:
37.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 749
THR A 796
MET A 799
GLY A 802
ASN A 848
LEU A 850
 GW7  A   1 (-3.3A)
GW7  A   1 (-4.0A)
None
GW7  A   1 (-3.6A)
None
GW7  A   1 (-4.2A)
 0.78A 4wa9A-2r4bA:
28.0		 4wa9A-2r4bA:
36.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 724
ALA A 749
LYS A 751
THR A 796
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.2A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.0A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.94A 4wa9A-2r4bA:
28.0		 4wa9A-2r4bA:
36.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 226
ALA A 247
LYS A 249
MET A 304
GLY A 307
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 ( 4.1A)
XK9  A1511 (-4.2A)
None
XK9  A1511 ( 3.7A)
XK9  A1511 (-4.6A)
 0.80A 4wa9A-2xk9A:
19.3		 4wa9A-2xk9A:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xk9 CHECKPOINT KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A 226
ALA A 247
MET A 304
GLY A 307
ASN A 352
LEU A 354
 XK9  A1511 (-3.8A)
XK9  A1511 ( 4.1A)
None
XK9  A1511 ( 3.7A)
None
XK9  A1511 (-4.6A)
 0.58A 4wa9A-2xk9A:
19.3		 4wa9A-2xk9A:
27.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 651
LYS A 653
THR A 699
MET A 702
GLY A 705
ASN A 751
LEU A 753
 Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.5A)
None
Q9G  A1898 ( 3.8A)
None
Q9G  A1898 (-4.3A)
 1.04A 4wa9A-2xyuA:
29.1		 4wa9A-2xyuA:
38.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A  51
LYS A  53
MET A 110
GLY A 113
ASN A 158
LEU A 160
 B49  A1294 (-3.2A)
None
None
B49  A1294 (-3.6A)
None
B49  A1294 (-4.4A)
 1.00A 4wa9A-2y7jA:
22.4		 4wa9A-2y7jA:
26.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 LEU A 253
ALA A 273
THR A 319
MET A 322
GLY A 325
ASN A 372
LEU A 374
ALA A 384
 None
 0.47A 4wa9A-2zv7A:
29.5		 4wa9A-2zv7A:
45.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 515
LYS A 517
GLY A 570
ASN A 631
LEU A 633
ALA A 643
 M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
M33  A1996 ( 4.8A)
None
M33  A1996 (-4.5A)
None
 0.98A 4wa9A-3b2tA:
30.4		 4wa9A-3b2tA:
40.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 487
ALA A 515
LYS A 517
GLY A 570
ASN A 631
LEU A 633
 M33  A1996 (-4.0A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
M33  A1996 ( 4.8A)
None
M33  A1996 (-4.5A)
 1.02A 4wa9A-3b2tA:
30.4		 4wa9A-3b2tA:
40.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 220
THR A 266
MET A 269
GLY A 272
ASN A 319
LEU A 321
 None
 0.33A 4wa9A-3d7uA:
30.0		 4wa9A-3d7uA:
44.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ALA A 663
LYS A 665
MET A 714
GLY A 717
ASN A 763
LEU A 765
 IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
None
IHZ  A1001 ( 3.9A)
None
IHZ  A1001 (-4.6A)
 0.92A 4wa9A-3dkoA:
27.7		 4wa9A-3dkoA:
36.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ALA A 665
THR A 713
MET A 716
GLY A 719
ASN A 765
LEU A 767
 None
None
None
GOL  A 403 (-3.4A)
None
None
 0.38A 4wa9A-3kulA:
31.0		 4wa9A-3kulA:
34.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzb EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 694
ALA A 719
THR A 766
GLY A 772
ASN A 818
LEU A 820
 ITI  A   1 (-3.9A)
ITI  A   1 (-2.9A)
ITI  A   1 (-3.8A)
ITI  A   1 (-3.5A)
None
ITI  A   1 (-4.6A)
 0.68A 4wa9A-3lzbA:
28.4		 4wa9A-3lzbA:
34.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		6 ALA A 229
THR A 279
GLY A 285
ASN A 337
LEU A 339
ALA A 349
 LDN  A   1 (-3.6A)
LDN  A   1 (-3.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.3A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.54A 4wa9A-3mdyA:
23.8		 4wa9A-3mdyA:
28.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 227
THR A 277
GLY A 283
ASN A 335
LEU A 337
ALA A 347
 LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.5A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.48A 4wa9A-3my0A:
24.1		 4wa9A-3my0A:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 192
ALA A 213
MET A 266
GLY A 269
ASN A 316
LEU A 318
 AMP  A 577 ( 4.3A)
AMP  A 577 (-3.4A)
None
None
AMP  A 577 (-4.2A)
AMP  A 577 (-4.8A)
 0.65A 4wa9A-3nyoA:
20.8		 4wa9A-3nyoA:
19.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 751
THR A 798
MET A 801
GLY A 804
ASN A 850
LEU A 852
 03Q  A   1 (-3.1A)
03Q  A   1 (-4.1A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.2A)
03Q  A   1 (-4.4A)
 0.62A 4wa9A-3pp0A:
30.7		 4wa9A-3pp0A:
35.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 726
ALA A 751
LYS A 753
THR A 798
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-3.8A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.1A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 1.02A 4wa9A-3pp0A:
30.7		 4wa9A-3pp0A:
35.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 217
THR A 267
GLY A 273
ASN A 327
LEU A 329
ALA A 339
 TAK  A   2 (-3.5A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
None
TAK  A   2 (-4.6A)
TAK  A   2 ( 4.2A)
 0.57A 4wa9A-3q4tA:
23.4		 4wa9A-3q4tA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 LEU A  63
ALA A  84
THR A 144
GLY A 150
ASN A 195
LEU A 197
 ANP  A1634 ( 4.3A)
ANP  A1634 (-3.6A)
ANP  A1634 (-4.6A)
None
CA  A 528 ( 3.0A)
ANP  A1634 (-4.4A)
 1.06A 4wa9A-3q5iA:
19.1		 4wa9A-3q5iA:
21.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 423
ALA A 443
LYS A 445
THR A 489
GLY A 495
ASN A 541
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
None
 0.84A 4wa9A-3sxsA:
30.9		 4wa9A-3sxsA:
41.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 423
ALA A 443
THR A 489
GLY A 495
ASN A 541
LEU A 543
 PP2  A   1 (-4.1A)
PP2  A   1 (-3.2A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
None
PP2  A   1 (-4.6A)
 0.54A 4wa9A-3sxsA:
30.9		 4wa9A-3sxsA:
41.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		6 LEU A 295
ALA A 315
MET A 366
GLY A 369
ASN A 421
LEU A 423
 None
 0.87A 4wa9A-3ulzA:
21.6		 4wa9A-3ulzA:
30.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 544
ALA A 570
LYS A 572
MET A 620
GLY A 623
ASN A 684
LEU A 686
 0F4  A 902 ( 4.2A)
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
None
0F4  A 902 (-3.4A)
None
0F4  A 902 (-4.5A)
 0.67A 4wa9A-3v5qA:
28.5		 4wa9A-3v5qA:
36.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 160
LYS A 146
GLY A 216
ASN A 261
LEU A 263
ALA A 273
 N13  A 501 ( 4.1A)
None
N13  A 501 (-3.5A)
None
N13  A 501 (-4.5A)
N13  A 501 ( 3.8A)
 0.78A 4wa9A-3w18A:
20.5		 4wa9A-3w18A:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w18 AURORA KINASE A

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 160
LYS A 162
GLY A 216
ASN A 261
LEU A 263
ALA A 273
 N13  A 501 ( 4.1A)
N13  A 501 (-2.9A)
N13  A 501 (-3.5A)
None
N13  A 501 (-4.5A)
N13  A 501 ( 3.8A)
 1.01A 4wa9A-3w18A:
20.5		 4wa9A-3w18A:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  75
ALA A  96
MET A 147
GLY A 150
ASN A 196
LEU A 198
 ANP  A 401 (-3.8A)
ANP  A 401 (-3.2A)
None
ANP  A 401 ( 4.3A)
MG  A 402 ( 2.9A)
ANP  A 401 (-4.8A)
 0.81A 4wa9A-3wigA:
21.1		 4wa9A-3wigA:
24.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A1951
ALA A1978
MET A2029
GLY A2032
ASN A2084
LEU A2086
 VGH  A3000 ( 4.4A)
VGH  A3000 (-3.4A)
None
VGH  A3000 (-3.5A)
None
VGH  A3000 (-4.3A)
 0.46A 4wa9A-3zbfA:
29.3		 4wa9A-3zbfA:
40.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 649
THR A 697
MET A 700
GLY A 703
ASN A 749
LEU A 751
 None
 0.21A 4wa9A-3zfxA:
30.3		 4wa9A-3zfxA:
41.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		6 ALA A 104
LYS A 106
GLY A 160
ASN A 205
LEU A 207
ALA A 217
 VX6  A 500 (-3.4A)
VX6  A 500 (-3.3A)
VX6  A 500 (-3.3A)
None
VX6  A 500 (-4.6A)
VX6  A 500 ( 4.2A)
 0.96A 4wa9A-4af3A:
18.4		 4wa9A-4af3A:
25.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af3 AURORA KINASE B

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  83
ALA A 104
LYS A 106
GLY A 160
ASN A 205
LEU A 207
 VX6  A 500 (-3.8A)
VX6  A 500 (-3.4A)
VX6  A 500 (-3.3A)
VX6  A 500 (-3.3A)
None
VX6  A 500 (-4.6A)
 0.88A 4wa9A-4af3A:
18.4		 4wa9A-4af3A:
25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 560
ALA A 586
MET A 636
GLY A 639
ASN A 697
LEU A 699
 LTI  A1839 ( 4.2A)
LTI  A1839 (-3.3A)
None
LTI  A1839 (-3.4A)
None
LTI  A1839 (-4.2A)
 0.64A 4wa9A-4at3A:
29.2		 4wa9A-4at3A:
36.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A 121
THR A 169
MET A 172
GLY A 175
ASN A 221
LEU A 223
 30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.4A)
30K  A1365 (-4.5A)
 0.32A 4wa9A-4aw5A:
29.1		 4wa9A-4aw5A:
38.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 ALA A 233
THR A 283
GLY A 289
ASN A 341
LEU A 343
ALA A 353
 TAK  A1507 (-3.3A)
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
None
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.39A 4wa9A-4c02A:
24.0		 4wa9A-4c02A:
27.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 653
THR A 701
MET A 704
GLY A 707
ASN A 771
LEU A 773
ALA A 783
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
None
None
None
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
 0.67A 4wa9A-4ckrA:
26.2		 4wa9A-4ckrA:
37.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 LEU A 616
ALA A 653
LYS A 655
THR A 701
MET A 704
ASN A 771
LEU A 773
ALA A 783
 None
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.6A)
None
None
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
 1.32A 4wa9A-4ckrA:
26.2		 4wa9A-4ckrA:
37.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f0i HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 515
ALA A 541
MET A 591
GLY A 594
ASN A 654
LEU A 656
 None
 0.44A 4wa9A-4f0iA:
27.5		 4wa9A-4f0iA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A1122
ALA A1148
MET A1199
GLY A1202
ASN A1254
LEU A1256
 0UV  A1501 (-3.8A)
0UV  A1501 (-3.4A)
None
0UV  A1501 (-3.6A)
0UV  A1501 ( 4.9A)
0UV  A1501 (-4.6A)
 0.51A 4wa9A-4fodA:
27.1		 4wa9A-4fodA:
37.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 132
ALA A 156
THR A 205
GLY A 211
ASN A 257
LEU A 259
 1G0  A 401 ( 4.5A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
None
1G0  A 401 (-4.6A)
 0.74A 4wa9A-4id7A:
30.4		 4wa9A-4id7A:
40.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 LEU A 273
ALA A 293
LYS A 295
MET A 341
GLY A 344
LEU A 393
 0J9  A 601 (-4.0A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
None
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
 1.01A 4wa9A-4k11A:
28.7		 4wa9A-4k11A:
35.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 273
ALA A 293
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 0J9  A 601 (-4.0A)
0J9  A 601 (-3.3A)
None
0J9  A 601 ( 4.1A)
None
0J9  A 601 (-4.5A)
0J9  A 601 (-3.5A)
 0.64A 4wa9A-4k11A:
28.7		 4wa9A-4k11A:
35.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 LEU A  33
ALA A  54
GLY A 105
ASN A 151
LEU A 153
ALA A 163
 GOL  A 404 ( 3.6A)
GOL  A 404 ( 3.1A)
GOL  A 404 (-3.6A)
None
GOL  A 403 ( 4.4A)
GOL  A 403 ( 3.0A)
 0.79A 4wa9A-4lg4A:
22.3		 4wa9A-4lg4A:
24.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 LEU A 273
ALA A 293
MET A 341
GLY A 344
ASN A 391
LEU A 393
ALA A 403
 VGG  A 601 (-3.2A)
VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.2A)
None
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.50A 4wa9A-4lggA:
28.7		 4wa9A-4lggA:
46.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA A  49
LYS A  51
THR A  95
MET A  98
GLY A 101
LEU A 150
 ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
ANP  A 401 (-3.8A)
None
None
ANP  A 401 (-4.8A)
 0.95A 4wa9A-4m69A:
23.1		 4wa9A-4m69A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		6 ALA A  49
THR A  95
MET A  98
GLY A 101
LEU A 150
ALA A 160
 ANP  A 401 (-3.1A)
ANP  A 401 (-3.8A)
None
None
ANP  A 401 (-4.8A)
None
 0.79A 4wa9A-4m69A:
23.1		 4wa9A-4m69A:
29.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  46
ALA A  67
LYS A  69
THR A 123
GLY A 128
ASN A 178
LEU A 180
 SIN  A 401 ( 3.9A)
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-3.5A)
None
SIN  A 401 ( 4.5A)
 1.36A 4wa9A-4o38A:
17.5		 4wa9A-4o38A:
25.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 ALA A 644
THR A 692
MET A 695
GLY A 698
ASN A 744
LEU A 746
 None
 0.42A 4wa9A-4p2kA:
29.8		 4wa9A-4p2kA:
38.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 LEU A  14
ALA A  35
LYS A  37
MET A  84
GLY A  87
ASN A 134
LEU A 136
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
 0.99A 4wa9A-4ueuA:
29.9		 4wa9A-4ueuA:
64.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 LEU A  14
ALA A  35
THR A  81
MET A  84
GLY A  87
ASN A 134
LEU A 136
ALA A 146
 ACP  A1264 ( 4.5A)
ACP  A1264 (-2.9A)
ACP  A1264 (-4.5A)
None
ACP  A1264 (-3.5A)
None
ACP  A1264 ( 4.8A)
None
 0.48A 4wa9A-4ueuA:
29.9		 4wa9A-4ueuA:
64.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4usf STE20-LIKE
SERINE/THREONINE-PRO
TEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 LEU A  40
ALA A  61
GLY A 114
ASN A 160
LEU A 162
ALA A 172
PHE A 174
 6UI  A 700 ( 4.9A)
6UI  A 700 (-3.3A)
6UI  A 700 ( 4.2A)
None
6UI  A 700 (-4.2A)
6UI  A 700 ( 4.1A)
None
 1.01A 4wa9A-4usfA:
21.5		 4wa9A-4usfA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 193
ALA A 214
LYS A 216
GLY A 270
ASN A 319
LEU A 321
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
None
ANW  A 601 ( 4.5A)
None
ANW  A 601 (-4.9A)
 1.10A 4wa9A-4wboA:
21.6		 4wa9A-4wboA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		6 LEU A 193
ALA A 214
MET A 267
GLY A 270
ASN A 319
LEU A 321
 ANW  A 601 ( 4.0A)
ANW  A 601 (-3.4A)
None
ANW  A 601 ( 4.5A)
None
ANW  A 601 (-4.9A)
 0.79A 4wa9A-4wboA:
21.6		 4wa9A-4wboA:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 7 LEU B 267
ALA B 288
LYS B 290
THR B 334
MET B 337
GLY B 340
LEU B 389
 1N1  B 601 (-3.7A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 (-3.3A)
None
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
 0.72A 4wa9A-4xeyB:
37.7		 4wa9A-4xeyB:
78.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 8 LEU B 267
ALA B 288
THR B 334
MET B 337
GLY B 340
ASN B 387
LEU B 389
ALA B 399
 1N1  B 601 (-3.7A)
1N1  B 601 (-3.5A)
1N1  B 601 (-3.3A)
None
1N1  B 601 (-3.5A)
None
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.46A 4wa9A-4xeyB:
37.7		 4wa9A-4xeyB:
78.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 8 LEU B 267
ALA B 288
THR B 334
MET B 337
GLY B 340
LEU B 389
ALA B 399
PHE B 401
 1N1  B 601 (-3.7A)
1N1  B 601 (-3.5A)
1N1  B 601 (-3.3A)
None
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
None
 0.76A 4wa9A-4xeyB:
37.7		 4wa9A-4xeyB:
78.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 LEU A 408
ALA A 428
THR A 474
MET A 477
GLY A 480
ASN A 526
LEU A 528
 None
 0.63A 4wa9A-4xi2A:
27.8		 4wa9A-4xi2A:
33.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 LEU A 408
ALA A 428
THR A 474
MET A 477
GLY A 480
ASN A 526
LEU A 528
 746  A 702 (-3.8A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-2.8A)
746  A 702 (-4.4A)
 0.57A 4wa9A-4y93A:
28.6		 4wa9A-4y93A:
29.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 ALA A1108
LYS A1110
MET A1160
GLY A1163
ASN A1209
ALA A1221
 63K  A1401 (-3.5A)
None
None
63K  A1401 (-3.6A)
None
63K  A1401 (-3.3A)
 0.84A 4wa9A-5horA:
22.9		 4wa9A-5horA:
37.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hx6 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LYS A  45
MET A  95
GLY A  98
ASN A 143
LEU A 145
ALA A 155
 65U  A 301 (-3.4A)
None
None
None
None
65U  A 301 ( 3.9A)
 0.72A 4wa9A-5hx6A:
24.7		 4wa9A-5hx6A:
29.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LEU A 718
ALA A 743
LYS A 745
MET A 793
GLY A 796
ASN A 842
LEU A 844
 6HJ  A1101 ( 4.6A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
None
6HJ  A1101 ( 4.5A)
None
6HJ  A1101 ( 4.8A)
 1.03A 4wa9A-5j9zA:
28.1		 4wa9A-5j9zA:
35.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 209
ALA A 228
GLY A 289
ASN A 336
LEU A 338
ALA A 348
 None
6UY  A 501 (-3.4A)
6UY  A 501 ( 4.3A)
6UY  A 501 (-4.4A)
6UY  A 501 (-4.5A)
6UY  A 501 (-3.4A)
 0.62A 4wa9A-5ko1A:
23.2		 4wa9A-5ko1A:
29.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 663
LYS A 665
THR A 711
MET A 714
ASN A 763
LEU A 765
PHE A 777
 6P6  A1001 (-3.3A)
None
6P6  A1001 (-3.5A)
None
None
6P6  A1001 (-4.5A)
DIO  A1002 (-4.5A)
 1.29A 4wa9A-5l6oA:
28.7		 4wa9A-5l6oA:
38.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 593
ALA A 617
MET A 674
GLY A 677
ASN A 728
ALA A 740
 7AE  A1000 ( 3.9A)
7AE  A1000 (-3.3A)
None
7AE  A1000 ( 3.7A)
7AE  A1000 (-4.7A)
7AE  A1000 ( 3.7A)
 0.71A 4wa9A-5td2A:
27.8		 4wa9A-5td2A:
42.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tos SERINE/THREONINE-PRO
TEIN KINASE BIK1

(Arabidopsis
thaliana) 		no annotation 6 ALA A 103
LYS A 105
MET A 153
GLY A 156
ASN A 207
LEU A 209
 None
 0.78A 4wa9A-5tosA:
20.6		 4wa9A-5tosA:
12.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 LEU A 542
ALA A 565
MET A 623
GLY A 626
ASN A 677
ALA A 689
 7YS  A9001 (-4.1A)
7YS  A9001 (-3.3A)
7YS  A9001 (-4.7A)
7YS  A9001 (-3.4A)
None
7YS  A9001 (-3.4A)
 0.71A 4wa9A-5u6bA:
28.0		 4wa9A-5u6bA:
43.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 7 ALA A  45
THR A  95
MET A  98
GLY A 101
ASN A 151
LEU A 153
ALA A 163
 9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
None
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.60A 4wa9A-5w5jA:
23.8		 4wa9A-5w5jA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 7 LEU A  24
ALA A  45
THR A  95
MET A  98
GLY A 101
ASN A 151
LEU A 153
 9WS  A 401 ( 4.2A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
None
9WS  A 401 (-4.6A)
 0.74A 4wa9A-5w5jA:
23.8		 4wa9A-5w5jA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 LEU A 891
ALA A 917
LYS A 919
THR A 963
GLY A 969
LEU A1017
 ANP  A1201 (-4.1A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.81A 4wa9A-5wnoA:
26.8		 4wa9A-5wnoA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 8 LEU A 197
ALA A 217
LYS A 219
THR A 264
MET A 267
GLY A 270
ASN A 317
LEU A 319
 FKY  A9001 (-4.1A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.0A)
None
FKY  A9001 (-3.3A)
None
FKY  A9001 ( 4.9A)
 0.78A 4wa9A-6cz4A:
26.9		 4wa9A-6cz4A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 6 ALA A 211
LYS A 213
MET A 265
GLY A 268
ASN A 316
LEU A 318
 CJT  A 502 (-3.4A)
CJT  A 502 (-3.0A)
CJT  A 502 (-4.9A)
CJT  A 502 ( 4.3A)
None
CJT  A 502 (-4.7A)
 0.95A 4wa9A-6f3dA:
22.0		 4wa9A-6f3dA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fdy -

(-) 		no annotation 6 LEU U  20
ALA U  42
GLY U  97
ASN U 142
LEU U 144
ALA U 156
 DB8  U 301 (-3.7A)
DB8  U 301 (-3.6A)
DB8  U 301 ( 4.1A)
DB8  U 301 (-4.5A)
DB8  U 301 (-4.8A)
DB8  U 301 ( 4.2A)
 0.86A 4wa9A-6fdyU:
21.3		 4wa9A-6fdyU:
undetectable