SIMILAR PATTERNS OF AMINO ACIDS FOR 4WA5_A_ZMRA501_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nmb N9 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 ARG N 152
ARG N 156
TRP N 178
ILE N 222
ARG N 224
 None
 0.63A 4wa5A-1nmbN:
61.3		 4wa5A-1nmbN:
37.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0z NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 ARG A 158
ARG A 162
TRP A 185
ILE A 229
ARG A 231
 None
 0.57A 4wa5A-1v0zA:
62.9		 4wa5A-1v0zA:
48.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vcj NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		5 ARG A 150
ARG A 154
TRP A 177
ILE A 221
ARG A 223
 IBA  A   1 (-3.9A)
IBA  A   1 (-4.1A)
None
IBA  A   1 ( 4.3A)
IBA  A   1 ( 4.5A)
 0.72A 4wa5A-1vcjA:
52.5		 4wa5A-1vcjA:
35.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xog NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 ARG A 153
ARG A 157
TRP A 180
ILE A 224
ARG A 226
 ABW  A1000 (-4.1A)
ABW  A1000 (-4.2A)
None
ABW  A1000 ( 4.7A)
None
 0.64A 4wa5A-1xogA:
62.3		 4wa5A-1xogA:
44.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2htv NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 ARG A 152
ARG A 156
TRP A 178
ILE A 222
ARG A 224
 None
 0.59A 4wa5A-2htvA:
67.7		 4wa5A-2htvA:
61.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nwb CONSERVED DOMAIN
PROTEIN

(Shewanella
oneidensis) 		PF08933
(DUF1864) 		4 ARG A 368
ARG A 369
ILE A 377
ARG A 374
 None
HEM  A 401 (-2.2A)
None
None
 1.20A 4wa5A-2nwbA:
undetectable		 4wa5A-2nwbA:
23.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ckz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ARG A 152
ARG A 156
TRP A 178
ILE A 222
 ZMR  A 469 (-3.9A)
ZMR  A 469 (-3.4A)
None
None
 0.75A 4wa5A-3ckzA:
67.5		 4wa5A-3ckzA:
57.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ckz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ARG A 152
TRP A 178
ILE A 222
ARG A 224
 ZMR  A 469 (-3.9A)
None
None
ZMR  A 469 (-4.4A)
 0.30A 4wa5A-3ckzA:
67.5		 4wa5A-3ckzA:
57.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 ARG A 152
ARG A 156
TRP A 178
ILE A 222
ARG A 224
 LNV  A 901 (-4.0A)
LNV  A 901 (-4.0A)
None
None
LNV  A 901 (-4.1A)
 0.55A 4wa5A-3ti8A:
72.8		 4wa5A-3ti8A:
69.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tia NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 ARG A 152
ARG A 156
TRP A 178
ILE A 222
ARG A 224
 LNV  A 801 (-3.9A)
LNV  A 801 (-4.0A)
None
None
LNV  A 801 (-4.2A)
 0.52A 4wa5A-3tiaA:
63.0		 4wa5A-3tiaA:
42.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4b7j NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ARG A 152
ARG A 156
TRP A 179
ARG A 225
 G39  A1470 (-3.9A)
None
None
G39  A1470 (-4.4A)
 0.65A 4wa5A-4b7jA:
67.8		 4wa5A-4b7jA:
49.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		5 ARG A 149
ARG A 153
TRP A 176
ILE A 220
ARG A 222
 ZMR  A 700 (-4.0A)
ZMR  A 700 (-4.2A)
None
None
ZMR  A 700 (-3.8A)
 0.54A 4wa5A-4cpnA:
52.8		 4wa5A-4cpnA:
31.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h53 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 ARG A 152
ARG A 156
TRP A 178
ILE A 222
ARG A 224
 SLB  A 512 (-3.8A)
None
None
None
SLB  A 512 (-4.2A)
 0.53A 4wa5A-4h53A:
63.3		 4wa5A-4h53A:
48.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 ARG A 152
ARG A 156
TRP A 178
ILE A 222
ARG A 224
 G39  A 509 (-3.9A)
None
None
G39  A 509 ( 4.1A)
G39  A 509 (-4.7A)
 0.54A 4wa5A-4hzzA:
62.1		 4wa5A-4hzzA:
47.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mju NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 ARG A 152
ARG A 156
TRP A 178
ILE A 222
ARG A 224
 27S  A 501 (-4.2A)
None
None
27S  A 501 ( 4.6A)
27S  A 501 (-4.3A)
 0.69A 4wa5A-4mjuA:
74.1		 4wa5A-4mjuA:
90.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qn3 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		5 ARG A  70
ARG A  74
TRP A  97
ILE A 141
ARG A 143
 None
 0.64A 4wa5A-4qn3A:
62.4		 4wa5A-4qn3A:
44.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9q ENHANCER OF
POLYCOMB-LIKE
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 4 ARG G 282
TRP G 279
ILE G 214
ARG G 280
 None
 1.46A 4wa5A-5j9qG:
undetectable		 4wa5A-5j9qG:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6br6 NEURAMINIDASE

(Influenza A
virus) 		no annotation 5 ARG A 152
ARG A 156
TRP A 178
ILE A 222
ARG A 224
 E3M  A 511 (-3.8A)
None
None
E3M  A 511 ( 4.3A)
E3M  A 511 (-3.8A)
 0.52A 4wa5A-6br6A:
63.4		 4wa5A-6br6A:
12.69