SIMILAR PATTERNS OF AMINO ACIDS FOR 4W5R_A_IPHA903_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oah CYTOCHROME C NITRITE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF02335
(Cytochrom_C552) 		4 TYR A 112
LYS A  81
GLU A 114
TYR A  79
 HEM  A1520 (-4.9A)
None
CA  A1526 ( 3.4A)
None
 1.44A 4w5rA-1oahA:
0.0		 4w5rA-1oahA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pml TISSUE PLASMINOGEN
ACTIVATOR KRINGLE 2

(Homo sapiens) 		PF00051
(Kringle) 		4 TYR A   2
LYS A  59
GLU A  17
TYR A  74
 None
 1.47A 4w5rA-1pmlA:
undetectable		 4w5rA-1pmlA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipy FLAVIN-CONTAINING
MONOOXYGENASE

(Roseovarius
nubinhibens) 		PF00743
(FMO-like) 		4 TYR A 299
LYS A 300
GLU A 379
TYR A 376
 None
 1.40A 4w5rA-5ipyA:
0.0		 4w5rA-5ipyA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 4 TYR A 130
LYS A 118
GLU A 168
TYR A 115
 None
 1.44A 4w5rA-5kucA:
0.0		 4w5rA-5kucA:
18.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 4 TYR A 655
LYS A 661
GLU A 696
TYR A 699
 None
 0.92A 4w5rA-5vm9A:
58.3		 4w5rA-5vm9A:
79.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 4 TYR A 654
LYS A 660
GLU A 695
TYR A 698
 None
None
IPH  A 901 (-3.6A)
IPH  A 901 ( 4.9A)
 0.85A 4w5rA-5weaA:
58.0		 4w5rA-5weaA:
undetectable