SIMILAR PATTERNS OF AMINO ACIDS FOR 4W5Q_A_IPHA904_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB

(Thermus
thermophilus) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 PHE A 324
VAL A 133
ALA A  57
PHE A   3
 None
 1.44A 4w5qA-1c4oA:
undetectable		 4w5qA-1c4oA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f9k ACIDIC LECTIN

(Psophocarpus
tetragonolobus) 		PF00139
(Lectin_legB) 		4 PHE A  93
VAL A  95
ALA A 121
PHE A 199
 None
 1.41A 4w5qA-1f9kA:
0.0		 4w5qA-1f9kA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gpz COMPLEMENT C1R
COMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 PHE A 641
VAL A 576
ALA A 642
PHE A 458
 None
 1.41A 4w5qA-1gpzA:
0.0		 4w5qA-1gpzA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1md7 C1R COMPLEMENT
SERINE PROTEASE

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		4 PHE A 641
VAL A 576
ALA A 642
PHE A 458
 None
 1.38A 4w5qA-1md7A:
0.0		 4w5qA-1md7A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3m PROLYL-TRNA
SYNTHETASE

(Enterococcus
faecalis) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF04073
(tRNA_edit) 		4 PHE A 283
VAL A 281
ALA A 317
PHE A 330
 None
 1.42A 4w5qA-2j3mA:
2.8		 4w5qA-2j3mA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mzt PROTEIN HRB1

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		4 PHE A 364
VAL A 420
ALA A 405
PHE A 396
 None
 1.46A 4w5qA-2mztA:
2.4		 4w5qA-2mztA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp4 BILE SALT
SULFOTRANSFERASE

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 PHE A 109
VAL A 116
ALA A 114
PHE A 201
 None
 1.32A 4w5qA-2qp4A:
3.0		 4w5qA-2qp4A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqr JMJC
DOMAIN-CONTAINING
HISTONE
DEMETHYLATION
PROTEIN 3A

(Homo sapiens) 		no annotation 4 PHE A 977
VAL A 930
ALA A 979
PHE A 937
 None
 1.47A 4w5qA-2qqrA:
3.6		 4w5qA-2qqrA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy0 COMPLEMENT C1R
SUBCOMPONENT

(Homo sapiens) 		PF00089
(Trypsin) 		4 PHE B 641
VAL B 576
ALA B 642
PHE B 458
 None
 1.45A 4w5qA-2qy0B:
undetectable		 4w5qA-2qy0B:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4f PEROXIDASE YCDB

(Escherichia
coli) 		PF04261
(Dyp_perox) 		4 PHE A  42
VAL A 142
ALA A  41
PHE A 368
 None
 1.08A 4w5qA-2y4fA:
undetectable		 4w5qA-2y4fA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0f XYLOGLUCANASE

(Geotrichum sp.
M128) 		no annotation 4 PHE A 527
VAL A 498
ALA A 515
PHE A 479
 None
 1.41A 4w5qA-3a0fA:
undetectable		 4w5qA-3a0fA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b97 ALPHA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 PHE A 250
VAL A 245
ALA A 163
PHE A 167
 None
 1.48A 4w5qA-3b97A:
undetectable		 4w5qA-3b97A:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3foa TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N) 		4 PHE A  33
VAL A  80
ALA A  30
PHE A 362
 None
 1.32A 4w5qA-3foaA:
2.2		 4w5qA-3foaA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfq FMN-DEPENDENT
NADPH-AZOREDUCTASE

(Bacillus
subtilis) 		PF03358
(FMN_red) 		4 PHE A  88
VAL A  54
ALA A  85
PHE A  37
 None
 1.23A 4w5qA-3gfqA:
2.1		 4w5qA-3gfqA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv4 PUTATIVE
OXIDOREDUCTASE

(Staphylococcus
aureus) 		PF11009
(DUF2847) 		4 PHE A  80
VAL A  23
ALA A  79
PHE A  40
 None
 1.31A 4w5qA-3iv4A:
undetectable		 4w5qA-3iv4A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2n TAIL SHEATH PROTEIN
GP18

(Escherichia
virus T4) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		4 PHE U  33
VAL U  80
ALA U  30
PHE U 362
 None
 1.32A 4w5qA-3j2nU:
undetectable		 4w5qA-3j2nU:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7u ANTIBODY

(Lama glama) 		PF07686
(V-set) 		4 PHE A  59
VAL A 105
ALA A  50
PHE A  37
 None
 1.37A 4w5qA-3k7uA:
undetectable		 4w5qA-3k7uA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0l SERINE
HYDROXYMETHYLTRANSFE
RASE

(Campylobacter
jejuni) 		PF00464
(SHMT) 		4 PHE A 193
VAL A 217
ALA A 194
PHE A 212
 None
 1.12A 4w5qA-3n0lA:
2.2		 4w5qA-3n0lA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppx VON WILLEBRAND
FACTOR

(Homo sapiens) 		PF00092
(VWA) 		4 PHE A1501
VAL A1537
ALA A1500
PHE A1552
 None
 1.25A 4w5qA-3ppxA:
5.6		 4w5qA-3ppxA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s0m OXALATE
DECARBOXYLASE OXDC

(Bacillus
subtilis) 		PF00190
(Cupin_1) 		4 PHE A 155
VAL A  82
ALA A  80
PHE A  52
 CO3  A 600 (-4.6A)
None
None
None
 1.47A 4w5qA-3s0mA:
undetectable		 4w5qA-3s0mA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s98 INTERFERON
ALPHA/BETA RECEPTOR
1

(Homo sapiens) 		PF01108
(Tissue_fac)
PF09294
(Interfer-bind) 		4 PHE A  96
VAL A  69
ALA A  99
PHE A  62
 None
 1.27A 4w5qA-3s98A:
undetectable		 4w5qA-3s98A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4o HAPTOGLOBIN

(Sus scrofa) 		PF00089
(Trypsin) 		4 PHE C 300
VAL C 222
ALA C 301
PHE C 114
 None
 1.43A 4w5qA-4f4oC:
undetectable		 4w5qA-4f4oC:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnv HEPARINASE III
PROTEIN, HEPARITIN
SULFATE LYASE

(Bacteroides
thetaiotaomicron) 		PF07940
(Hepar_II_III)
PF16889
(Hepar_II_III_N) 		4 PHE A 675
VAL A 687
ALA A 685
PHE A 554
 None
 1.49A 4w5qA-4fnvA:
undetectable		 4w5qA-4fnvA:
23.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		4 PHE A 585
VAL A 589
ALA A 618
PHE A 651
 None
 0.20A 4w5qA-4krfA:
53.7		 4w5qA-4krfA:
82.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwe SUGAR-BINDING
TRANSPORT PROTEIN

(Yersinia pestis) 		PF13407
(Peripla_BP_4) 		4 PHE A 215
VAL A 240
ALA A 216
PHE A 260
 None
 1.39A 4w5qA-4rweA:
7.3		 4w5qA-4rweA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tlh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL

(Clostridium
perfringens) 		PF00936
(BMC) 		4 PHE A 176
VAL A 151
ALA A 187
PHE A 203
 None
 0.92A 4w5qA-4tlhA:
undetectable		 4w5qA-4tlhA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjg HAPTOGLOBIN

(Homo sapiens) 		no annotation 4 PHE C 355
VAL C 277
ALA C 356
PHE C 169
 None
 1.41A 4w5qA-4wjgC:
undetectable		 4w5qA-4wjgC:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0l HAPTOGLOBIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 PHE C 359
VAL C 281
ALA C 360
PHE C 173
 None
 1.41A 4w5qA-4x0lC:
undetectable		 4w5qA-4x0lC:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8b PTAUREO1A LOV2
DOMAIN

(Phaeodactylum
tricornutum) 		PF13426
(PAS_9) 		4 PHE A 241
VAL A 349
ALA A 334
PHE A 331
 None
None
None
FMN  A 500 (-3.7A)
 1.23A 4w5qA-5a8bA:
undetectable		 4w5qA-5a8bA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bmo PUTATIVE
UNCHARACTERIZED
PROTEIN LNMX

(Streptomyces
atroolivaceus) 		PF02585
(PIG-L) 		4 PHE A 239
VAL A 183
ALA A 238
PHE A 231
 None
 1.47A 4w5qA-5bmoA:
2.7		 4w5qA-5bmoA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb2 PROTEIN SEY1

(Candida
albicans) 		PF05879
(RHD3) 		4 PHE A 579
VAL A 675
ALA A 603
PHE A 671
 None
 1.46A 4w5qA-5cb2A:
undetectable		 4w5qA-5cb2A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh5 ISOPRENYL
TRANSFERASE

(Streptococcus
pneumoniae) 		PF01255
(Prenyltransf) 		4 PHE A 143
VAL A  69
ALA A 144
PHE A 210
 None
 1.44A 4w5qA-5kh5A:
2.5		 4w5qA-5kh5A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkm PROTEIN SMG-8

(Caenorhabditis
elegans) 		PF10220
(Smg8_Smg9) 		4 PHE E 191
VAL E 249
ALA E 190
PHE E 294
 None
 1.42A 4w5qA-5nkmE:
3.5		 4w5qA-5nkmE:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti1 FUMARYLACETOACETATE
HYDROLASE

(Paraburkholderia
xenovorans) 		PF01557
(FAA_hydrolase)
PF09298
(FAA_hydrolase_N) 		4 PHE A  81
VAL A  49
ALA A  61
PHE A  39
 None
 1.15A 4w5qA-5ti1A:
undetectable		 4w5qA-5ti1A:
22.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 4 PHE A 588
VAL A 592
ALA A 621
PHE A 654
 None
 0.33A 4w5qA-5vm9A:
50.1		 4w5qA-5vm9A:
79.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 4 PHE A 587
VAL A 591
ALA A 620
PHE A 653
 None
 0.25A 4w5qA-5weaA:
53.2		 4w5qA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avy ACYL-PROTEIN
THIOESTERASE 2

(Zea mays) 		no annotation 4 PHE A  84
VAL A  86
ALA A  82
PHE A  75
 None
 1.49A 4w5qA-6avyA:
4.6		 4w5qA-6avyA:
undetectable