SIMILAR PATTERNS OF AMINO ACIDS FOR 4W5Q_A_IPHA902_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brl BACTERIAL LUCIFERASE

(Vibrio harveyi) 		PF00296
(Bac_luciferase) 		4 CYH A 325
ILE A 229
ILE A 311
ASP A 314
 None
 1.09A 4w5qA-1brlA:
undetectable		 4w5qA-1brlA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt0 PROTEIN
(UBIQUITIN-LIKE
PROTEIN 7, RUB1)

(Arabidopsis
thaliana) 		PF00240
(ubiquitin) 		4 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.80A 4w5qA-1bt0A:
undetectable		 4w5qA-1bt0A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9l CLATHRIN

(Rattus
norvegicus) 		PF01394
(Clathrin_propel)
PF09268
(Clathrin-link) 		4 ARG A  64
ILE A  66
GLN A  49
ILE A  62
 None
 1.15A 4w5qA-1c9lA:
0.0		 4w5qA-1c9lA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtd METALLOCARBOXYPEPTID
ASE INHIBITOR

(Hirudo
medicinalis) 		no annotation 4 ARG B  59
GLN B  57
ILE B  21
ASP B   6
 None
 0.99A 4w5qA-1dtdB:
0.6		 4w5qA-1dtdB:
5.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekq HYDROXYETHYLTHIAZOLE
KINASE

(Bacillus
subtilis) 		PF02110
(HK) 		4 ARG A 121
ILE A 120
ILE A 222
ASP A 172
 None
 1.16A 4w5qA-1ekqA:
0.0		 4w5qA-1ekqA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0z THIS PROTEIN

(Escherichia
coli) 		PF02597
(ThiS) 		4 ILE A  40
GLN A  39
ILE A  57
ASP A  55
 None
 1.07A 4w5qA-1f0zA:
undetectable		 4w5qA-1f0zA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 ARG A 770
GLN A 567
ILE A 619
ASP A 570
 None
 1.19A 4w5qA-1hwwA:
0.0		 4w5qA-1hwwA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0z ACLACINOMYCIN
METHYLESTERASE

(Streptomyces
purpurascens) 		PF00561
(Abhydrolase_1) 		4 ARG A   4
ILE A   5
ILE A  55
ASP A  17
 None
 1.17A 4w5qA-1q0zA:
3.6		 4w5qA-1q0zA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sif UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.62A 4w5qA-1sifA:
undetectable		 4w5qA-1sifA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uec NEUTROPHIL CYTOSOL
FACTOR 1

(Homo sapiens) 		PF00018
(SH3_1)
PF16621
(NECFESHC) 		4 ARG A 292
ILE A 294
GLN A 291
ASP A 286
 None
 1.01A 4w5qA-1uecA:
2.1		 4w5qA-1uecA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE

(Thermococcus
profundus) 		PF00155
(Aminotran_1_2) 		4 ILE A 278
GLN A 281
ILE A 283
ASP A 284
 None
 1.15A 4w5qA-1wstA:
2.6		 4w5qA-1wstA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9a NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Entamoeba
histolytica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A 173
GLN A 251
ILE A 274
ASP A 275
 None
 1.18A 4w5qA-1y9aA:
undetectable		 4w5qA-1y9aA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE

(Entamoeba
histolytica) 		PF05770
(Ins134_P3_kin) 		4 ILE X 241
GLN X 190
ILE X 177
ASP X 275
 None
None
ADP  X 871 (-4.6A)
MG  X1295 (-3.2A)
 1.03A 4w5qA-1z2oX:
3.6		 4w5qA-1z2oX:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2apn PROTEIN HI1723

(Haemophilus
influenzae) 		PF01521
(Fe-S_biosyn) 		4 ILE A  80
GLN A  77
ILE A  71
ASP A  72
 None
 1.20A 4w5qA-2apnA:
undetectable		 4w5qA-2apnA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g17 N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Salmonella
enterica) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ILE A 218
GLN A 160
ILE A 167
ASP A 168
 None
 1.17A 4w5qA-2g17A:
2.8		 4w5qA-2g17A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1k PANCREATIC AND
DUODENAL HOMEOBOX 1

(Mesocricetus
auratus) 		PF00046
(Homeobox) 		4 ARG A  31
ILE A  47
GLN A  50
ILE A  26
 None
 0.93A 4w5qA-2h1kA:
undetectable		 4w5qA-2h1kA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inr DNA TOPOISOMERASE 4
SUBUNIT A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV) 		4 ILE A 188
GLN A 189
ILE A 195
ASP A 196
 None
None
None
EDO  A 496 ( 3.1A)
 1.15A 4w5qA-2inrA:
undetectable		 4w5qA-2inrA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jif SHORT/BRANCHED CHAIN
SPECIFIC ACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 CYH A 139
ILE A 141
GLN A 142
ILE A 105
 None
 1.13A 4w5qA-2jifA:
undetectable		 4w5qA-2jifA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 ARG A 190
GLN A 194
ILE A 201
ASP A 200
 None
 1.17A 4w5qA-2nztA:
3.7		 4w5qA-2nztA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY

(Streptococcus
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ARG A 131
ILE A 446
ILE A 128
ASP A 124
 None
None
None
MN  A 460 ( 4.8A)
 1.13A 4w5qA-2pokA:
undetectable		 4w5qA-2pokA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qga ADENYLOSUCCINATE
LYASE

(Plasmodium
vivax) 		PF00206
(Lyase_1)
PF08328
(ASL_C) 		4 ILE B 421
GLN B 418
ILE B 412
ASP B 413
 None
 1.08A 4w5qA-2qgaB:
undetectable		 4w5qA-2qgaB:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		4 ARG A 694
ILE A 154
ILE A 120
ASP A 117
 None
 0.88A 4w5qA-2y3aA:
undetectable		 4w5qA-2y3aA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2za1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Plasmodium
falciparum) 		PF00215
(OMPdecase) 		4 CYH A  19
ILE A 290
ILE A 134
ASP A 136
 None
None
None
OMP  A 500 (-2.4A)
 1.16A 4w5qA-2za1A:
undetectable		 4w5qA-2za1A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN

(Aequorea
victoria;
Mus musculus) 		PF00240
(ubiquitin)
PF01353
(GFP) 		4 ILE A 276
GLN A 281
ILE A 255
ASP A 284
 None
 0.80A 4w5qA-3ai5A:
undetectable		 4w5qA-3ai5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blz NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION

(Shewanella
baltica) 		PF12893
(Lumazine_bd_2) 		4 ILE A  56
GLN A  57
ILE A  63
ASP A  64
 None
 1.11A 4w5qA-3blzA:
undetectable		 4w5qA-3blzA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3

(Mus musculus) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 CYH A 251
ILE A 252
GLN A 248
ILE A 258
 None
 1.01A 4w5qA-3cwgA:
undetectable		 4w5qA-3cwgA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdb PUTATIVE
PLP-DEPENDENT
BETA-CYSTATHIONASE

(Corynebacterium
diphtheriae) 		PF00155
(Aminotran_1_2) 		4 ARG A 126
GLN A 125
ILE A  97
ASP A  98
 None
None
None
EDO  A 387 (-3.7A)
 1.19A 4w5qA-3fdbA:
undetectable		 4w5qA-3fdbA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg6 ADSEVERIN

(Homo sapiens) 		PF00626
(Gelsolin) 		4 ARG A 408
ILE A 409
GLN A 410
ILE A 426
 None
 1.14A 4w5qA-3fg6A:
undetectable		 4w5qA-3fg6A:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 ARG B  63
ILE B  62
GLN B 110
ASP B 105
 None
 1.12A 4w5qA-3hhsB:
undetectable		 4w5qA-3hhsB:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k4x PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 ARG A 644
ILE A 645
ILE A 414
ASP A 417
 None
 1.09A 4w5qA-3k4xA:
undetectable		 4w5qA-3k4xA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9o UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
 0.77A 4w5qA-3k9oB:
undetectable		 4w5qA-3k9oB:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0g NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Ehrlichia
chaffeensis) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 CYH A  47
ILE A 102
ILE A 108
ASP A 140
 None
 1.17A 4w5qA-3l0gA:
2.9		 4w5qA-3l0gA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0w MONOUBIQUITINATED
PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00240
(ubiquitin)
PF02747
(PCNA_C) 		4 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
 0.59A 4w5qA-3l0wB:
undetectable		 4w5qA-3l0wB:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbh PUTATIVE
PHOSPHOMETHYLPYRIMID
INE KINASE

(Bacteroides
thetaiotaomicron) 		PF08543
(Phos_pyr_kin) 		4 ARG A  89
ILE A  91
GLN A  90
ASP A  61
 None
 0.98A 4w5qA-3mbhA:
3.3		 4w5qA-3mbhA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owq LIN1025 PROTEIN

(Listeria
innocua) 		PF03816
(LytR_cpsA_psr) 		4 ILE A  95
GLN A 221
ILE A 226
ASP A 223
 None
 1.20A 4w5qA-3owqA:
undetectable		 4w5qA-3owqA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3f RIBONUCLEASE/UBIQUIT
IN CHIMERIC PROTEIN

(Bacillus
amyloliquefaciens;
Homo sapiens) 		PF00240
(ubiquitin)
PF00545
(Ribonuclease) 		4 ILE A 148
GLN A 153
ILE A 127
ASP A 156
 None
SO4  A 191 ( 3.2A)
None
None
 0.72A 4w5qA-3q3fA:
undetectable		 4w5qA-3q3fA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A

(Fervidobacterium
nodosum) 		PF00150
(Cellulase) 		4 ARG A  82
ILE A  83
ILE A 198
ASP A 200
 None
 1.20A 4w5qA-3rjyA:
undetectable		 4w5qA-3rjyA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v47 FLAGELLIN

(Salmonella
enterica) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C) 		4 ILE C 115
GLN C 116
ILE C 122
ASP C 123
 None
 1.04A 4w5qA-3v47C:
undetectable		 4w5qA-3v47C:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vdz UBIQUITIN-40S
RIBOSOMAL PROTEIN
S27A

(Homo sapiens;
synthetic
construct) 		PF00240
(ubiquitin) 		4 ILE A 144
GLN A 149
ILE A 123
ASP A 152
 None
None
None
SO4  A 204 (-3.5A)
 0.87A 4w5qA-3vdzA:
undetectable		 4w5qA-3vdzA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3we7 PUTATIVE
UNCHARACTERIZED
PROTEIN PH0499

(Pyrococcus
horikoshii) 		PF02585
(PIG-L) 		4 ILE A 228
GLN A 223
ILE A  50
ASP A  47
 None
GOL  A 302 ( 4.6A)
None
ZN  A 301 ( 2.1A)
 1.11A 4w5qA-3we7A:
2.4		 4w5qA-3we7A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl4 UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF02585
(PIG-L) 		4 ILE A 223
GLN A 218
ILE A  46
ASP A  43
 HEZ  A 315 ( 4.3A)
TAM  A 309 ( 4.0A)
TAM  A 309 (-4.9A)
CD  A 301 ( 2.1A)
 0.88A 4w5qA-3wl4A:
3.1		 4w5qA-3wl4A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1

(Homo sapiens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 316
GLN A 319
ILE A 159
ASP A 161
 None
 1.01A 4w5qA-4a35A:
undetectable		 4w5qA-4a35A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au0 EXOGLUCANASE 2

(Trichoderma
reesei) 		PF01341
(Glyco_hydro_6) 		4 CYH A 245
ILE A 246
ILE A 187
ASP A 173
 None
 1.18A 4w5qA-4au0A:
undetectable		 4w5qA-4au0A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4da5 CHOLINE KINASE ALPHA

(Homo sapiens) 		PF01633
(Choline_kinase) 		4 ARG A 213
GLN A 308
ILE A 329
ASP A 330
 None
0H7  A 502 (-3.1A)
None
None
 1.03A 4w5qA-4da5A:
undetectable		 4w5qA-4da5A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs3 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADPH] FABI

(Staphylococcus
aureus) 		PF13561
(adh_short_C2) 		4 ILE A 120
GLN A  68
ILE A 127
ASP A  70
 0WD  A 301 (-3.8A)
0WD  A 301 ( 4.8A)
None
None
 1.15A 4w5qA-4fs3A:
2.8		 4w5qA-4fs3A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 4 ILE A  71
GLN A  72
ILE A  78
ASP A  79
 None
 1.18A 4w5qA-4fyeA:
2.5		 4w5qA-4fyeA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9z NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF17290
(Arena_ncap_C) 		4 ILE A 484
GLN A 462
ILE A 467
ASP A 466
 None
G  F   6 ( 3.9A)
None
G  F   6 ( 4.6A)
 1.19A 4w5qA-4g9zA:
undetectable		 4w5qA-4g9zA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5u CHIMERIC CEL6A

(Humicola
insolens;
Trichoderma
reesei;
Chaetomium
thermophilum) 		PF01341
(Glyco_hydro_6) 		4 CYH A 246
ILE A 247
ILE A 188
ASP A 174
 ACT  A 502 ( 3.9A)
None
None
EDO  A 507 (-4.2A)
 1.19A 4w5qA-4i5uA:
undetectable		 4w5qA-4i5uA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9x PROTEIN UL141

(Human
betaherpesvirus
5) 		PF16758
(UL141) 		4 ARG A  80
ILE A  79
ILE A  38
ASP A  37
 None
 0.97A 4w5qA-4i9xA:
undetectable		 4w5qA-4i9xA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ii2 UBIQUITIN-60S
RIBOSOMAL PROTEIN
L40

(Schizosaccharomyces
pombe) 		PF00240
(ubiquitin) 		4 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
EDO  B 101 (-2.8A)
None
None
 0.73A 4w5qA-4ii2B:
undetectable		 4w5qA-4ii2B:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ii3 UBIQUITIN-60S
RIBOSOMAL PROTEIN
L40

(Schizosaccharomyces
pombe) 		PF00240
(ubiquitin) 		4 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
 0.72A 4w5qA-4ii3B:
undetectable		 4w5qA-4ii3B:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans;
Acidaminococcus
fermentans) 		PF00766
(ETF_alpha)
PF01012
(ETF)
PF01012
(ETF) 		4 ARG A 204
CYH A 202
ILE A 203
ASP B 159
 None
 0.97A 4w5qA-4kpuA:
2.9		 4w5qA-4kpuA:
17.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		6 ARG A 686
CYH A 689
ILE A 690
GLN A 697
ILE A 700
ASP A 769
 None
 0.30A 4w5qA-4krfA:
53.7		 4w5qA-4krfA:
82.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		4 ILE A 132
GLN A 223
ILE A 229
ASP A 228
 AMP  A 501 ( 4.3A)
AMP  A 501 (-4.1A)
None
None
 1.00A 4w5qA-4m9dA:
undetectable		 4w5qA-4m9dA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqq MUSKELIN

(Mus musculus) 		PF06588
(Muskelin_N) 		4 CYH A 164
GLN A 162
ILE A 160
ASP A 157
 None
 1.00A 4w5qA-4pqqA:
undetectable		 4w5qA-4pqqA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um2 TELOMERASE-BINDING
PROTEIN EST1A

(Homo sapiens) 		PF10373
(EST1_DNA_bind)
PF10374
(EST1) 		4 ARG A 727
CYH A 728
ILE A 730
GLN A 726
 None
 1.02A 4w5qA-4um2A:
undetectable		 4w5qA-4um2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whb PHENYLUREA HYDROLASE
B

(Mycolicibacterium
brisbanense) 		no annotation 4 ARG E 136
ILE E 137
ILE E 407
ASP E 417
 None
 0.93A 4w5qA-4whbE:
undetectable		 4w5qA-4whbE:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsb POLYMERASE PB2

(Influenza A
virus) 		PF00604
(Flu_PB2) 		4 ARG C 650
ILE C 649
GLN C 614
ILE C 696
 None
 1.10A 4w5qA-4wsbC:
undetectable		 4w5qA-4wsbC:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrf TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY

(Bacillus cereus) 		PF01047
(MarR) 		4 ILE A  42
GLN A  39
ILE A  76
ASP A  77
 None
None
GOL  A 207 ( 4.5A)
None
 1.16A 4w5qA-4xrfA:
undetectable		 4w5qA-4xrfA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylr TUBULIN
POLYGLUTAMYLASE
TTLL7

(Homo sapiens) 		PF03133
(TTL) 		4 ARG A  94
ILE A  95
GLN A  93
ILE A 380
 None
 1.08A 4w5qA-4ylrA:
undetectable		 4w5qA-4ylrA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b83 TETRA UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A 120
GLN A 125
ILE A  99
ASP A 128
 None
 0.74A 4w5qA-5b83A:
undetectable		 4w5qA-5b83A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b83 TETRA UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A 196
GLN A 201
ILE A 175
ASP A 204
 None
 0.66A 4w5qA-5b83A:
undetectable		 4w5qA-5b83A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b83 TETRA UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A 272
GLN A 277
ILE A 251
ASP A 280
 None
 0.62A 4w5qA-5b83A:
undetectable		 4w5qA-5b83A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1t SMALL GTPASE EHRABX3

(Entamoeba
histolytica) 		PF00071
(Ras) 		4 ILE A 122
GLN A 121
ILE A 170
ASP A 173
 None
 1.16A 4w5qA-5c1tA:
3.5		 4w5qA-5c1tA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cy1 TRANSPOSON TN3
RESOLVASE

(Escherichia
coli) 		PF00239
(Resolvase)
PF02796
(HTH_7) 		4 ILE A  20
GLN A  19
ILE A  93
ASP A  94
 None
 1.20A 4w5qA-5cy1A:
3.5		 4w5qA-5cy1A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtu PRP28

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ARG A 304
ILE A 307
GLN A 303
ILE A 264
 None
None
ADP  A 801 (-2.8A)
None
 0.95A 4w5qA-5dtuA:
undetectable		 4w5qA-5dtuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0o COHESIN SUBUNIT
PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P

(Lachancea
thermotolerans) 		no annotation 4 ARG A 450
ILE A 454
ILE A 494
ASP A 496
 None
 1.09A 4w5qA-5f0oA:
undetectable		 4w5qA-5f0oA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftg CHOLINE KINASE ALPHA

(Homo sapiens) 		PF01633
(Choline_kinase) 		4 ARG A 213
GLN A 308
ILE A 329
ASP A 330
 None
NBR  A1458 ( 3.3A)
None
None
 1.16A 4w5qA-5ftgA:
undetectable		 4w5qA-5ftgA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gju ATP-DEPENDENT RNA
HELICASE DEAD

(Escherichia
coli) 		PF00270
(DEAD) 		4 CYH A  36
ILE A  37
GLN A  33
ILE A 210
 None
None
AMP  A 301 (-2.4A)
None
 0.95A 4w5qA-5gjuA:
undetectable		 4w5qA-5gjuA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h07 POLYUBIQUITIN-C

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.99A 4w5qA-5h07A:
undetectable		 4w5qA-5h07A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h07 POLYUBIQUITIN-C

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A 144
GLN A 149
ILE A 123
ASP A 152
 None
 0.87A 4w5qA-5h07A:
undetectable		 4w5qA-5h07A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h07 POLYUBIQUITIN-C

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A 244
GLN A 249
ILE A 223
ASP A 252
 None
 0.90A 4w5qA-5h07A:
undetectable		 4w5qA-5h07A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3x FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN

(Streptococcus
suis) 		PF05833
(FbpA) 		4 ARG A 164
ILE A 163
ILE A  99
ASP A  97
 None
 1.18A 4w5qA-5h3xA:
undetectable		 4w5qA-5h3xA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpt UBIQUITIN VARIANT
P2.3

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
 0.72A 4w5qA-5hptB:
undetectable		 4w5qA-5hptB:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvm ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Aspergillus
fumigatus) 		PF00982
(Glyco_transf_20) 		4 ILE A  84
GLN A  56
ILE A 147
ASP A 145
 None
 1.15A 4w5qA-5hvmA:
2.3		 4w5qA-5hvmA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG A 230
ILE A 273
GLN A 270
ILE A 221
 None
 1.19A 4w5qA-5i3oA:
undetectable		 4w5qA-5i3oA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipg BACTERIOFERRITIN
COMIGRATORY PROTEIN

(Xanthomonas
campestris) 		PF00578
(AhpC-TSA) 		4 ARG A  74
CYH A 102
ILE A 108
ASP A  75
 None
 1.12A 4w5qA-5ipgA:
undetectable		 4w5qA-5ipgA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		4 ILE A 102
GLN A 103
ILE A 109
ASP A 110
 None
 1.05A 4w5qA-5jboA:
undetectable		 4w5qA-5jboA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jyg ACTIN-LIKE ATPASE

(Magnetospirillum
magneticum) 		PF06723
(MreB_Mbl) 		4 ARG A  71
ILE A  70
ILE A  82
ASP A  84
 None
 1.20A 4w5qA-5jygA:
4.7		 4w5qA-5jygA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kgn 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Caenorhabditis
elegans) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 ARG A 450
ILE A 448
ILE A 407
ASP A 404
 None
 1.16A 4w5qA-5kgnA:
undetectable		 4w5qA-5kgnA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx8 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ARG A 111
ILE A  53
GLN A 114
ILE A 108
 None
 1.15A 4w5qA-5lx8A:
undetectable		 4w5qA-5lx8A:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx8 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ILE A  53
GLN A 114
ILE A 108
ASP A 107
 None
 1.10A 4w5qA-5lx8A:
undetectable		 4w5qA-5lx8A:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III

(Methanococcoides
burtonii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ARG A 389
ILE A 382
ILE A 362
ASP A 366
 None
None
None
MG  A 503 (-2.2A)
 1.00A 4w5qA-5macA:
undetectable		 4w5qA-5macA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o76 UBV.PCBL UBIQUITIN
VARIANT

(Homo sapiens) 		no annotation 4 ILE E  44
GLN E  49
ILE E  23
ASP E  52
 None
 0.66A 4w5qA-5o76E:
undetectable		 4w5qA-5o76E:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t81 EPOB

(Sorangium
cellulosum) 		PF00668
(Condensation) 		4 ILE A 203
GLN A  78
ILE A 394
ASP A  76
 None
 1.18A 4w5qA-5t81A:
undetectable		 4w5qA-5t81A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u32 TRNA LIGASE

(Candida
albicans) 		no annotation 4 ARG A 595
ILE A 596
ILE A 618
ASP A 615
 None
 1.11A 4w5qA-5u32A:
3.7		 4w5qA-5u32A:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucl POLYUBIQUITIN-B

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.87A 4w5qA-5uclA:
undetectable		 4w5qA-5uclA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v5g UBIQUITIN VARIANT
CC.4

(synthetic
construct) 		PF00240
(ubiquitin) 		4 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
EDO  B 101 ( 4.1A)
None
EDO  B 101 (-2.5A)
 0.65A 4w5qA-5v5gB:
undetectable		 4w5qA-5v5gB:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6a ME.2

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
 0.73A 4w5qA-5v6aB:
undetectable		 4w5qA-5v6aB:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vix POLYUBIQUITIN

(Naegleria
gruberi) 		PF00240
(ubiquitin) 		4 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.78A 4w5qA-5vixA:
undetectable		 4w5qA-5vixA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vix POLYUBIQUITIN

(Naegleria
gruberi) 		PF00240
(ubiquitin) 		4 ILE A 120
GLN A 125
ILE A  99
ASP A 128
 NO3  A 201 (-4.5A)
None
None
None
 0.68A 4w5qA-5vixA:
undetectable		 4w5qA-5vixA:
13.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 4 CYH A 692
ILE A 693
ILE A 703
ASP A 772
 None
 0.46A 4w5qA-5vm9A:
50.1		 4w5qA-5vm9A:
79.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0m TERMINAL
URIDYLYLTRANSFERASE
7

(Homo sapiens) 		PF00098
(zf-CCHC)
PF03828
(PAP_assoc) 		4 ARG A1165
CYH A1346
ILE A1353
ASP A1159
 None
None
U  H   1 ( 4.1A)
None
 1.16A 4w5qA-5w0mA:
undetectable		 4w5qA-5w0mA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 6 ARG A 688
CYH A 691
ILE A 692
GLN A 699
ILE A 702
ASP A 771
 None
 0.63A 4w5qA-5weaA:
53.2		 4w5qA-5weaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqn PROBABLE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00106
(adh_short) 		4 ILE A  86
GLN A 104
ILE A  97
ASP A  98
 None
 1.11A 4w5qA-5wqnA:
3.3		 4w5qA-5wqnA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi RIBOSOMAL PROTEIN
S3AE, PUTATIVE

(Trichomonas
vaginalis) 		PF01015
(Ribosomal_S3Ae) 		4 CYH B 197
ILE B 200
GLN B 159
ILE B 117
 None
 1.15A 4w5qA-5xyiB:
undetectable		 4w5qA-5xyiB:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 4 ARG A 586
ILE A 589
GLN A 585
ILE A 583
 None
 0.87A 4w5qA-5z06A:
undetectable		 4w5qA-5z06A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zc2 -

(-) 		no annotation 4 ARG B 240
ILE B  90
GLN B 239
ASP B 237
 None
 1.06A 4w5qA-5zc2B:
undetectable		 4w5qA-5zc2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brs PUTATIVE ZINC
PROTEASE

(Pectobacterium
atrosepticum) 		no annotation 4 ARG A 869
ILE A 872
GLN A 868
ASP A 863
 None
 1.10A 4w5qA-6brsA:
undetectable		 4w5qA-6brsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT

(Homo sapiens) 		no annotation 4 ILE A 125
GLN A 126
ILE A 100
ASP A  97
 None
 1.15A 4w5qA-6c9mA:
undetectable		 4w5qA-6c9mA:
undetectable