SIMILAR PATTERNS OF AMINO ACIDS FOR 4W5O_A_IPHA904_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bt0 PROTEIN
(UBIQUITIN-LIKE
PROTEIN 7, RUB1)

(Arabidopsis
thaliana) 		PF00240
(ubiquitin) 		4 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.85A 4w5oA-1bt0A:
undetectable		 4w5oA-1bt0A:
7.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ei6 PHOSPHONOACETATE
HYDROLASE

(Pseudomonas
fluorescens) 		PF01663
(Phosphodiest) 		4 ARG A 335
ILE A 336
PRO A  77
ILE A  82
 None
 0.99A 4w5oA-1ei6A:
0.0		 4w5oA-1ei6A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0z THIS PROTEIN

(Escherichia
coli) 		PF02597
(ThiS) 		4 ILE A  40
GLN A  39
ILE A  57
ASP A  55
 None
 1.01A 4w5oA-1f0zA:
undetectable		 4w5oA-1f0zA:
6.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1geg ACETOIN REDUCTASE

(Klebsiella
pneumoniae) 		PF00106
(adh_short) 		4 ILE A 184
GLN A 140
PRO A 182
ILE A 249
 None
BME  A1462 (-3.9A)
NAD  A2001 ( 3.7A)
None
 1.08A 4w5oA-1gegA:
3.6		 4w5oA-1gegA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpx ALPHA-AMINO ACID
ESTER HYDROLASE

(Xanthomonas
citri) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 GLN A 303
PRO A 199
ILE A 201
ASP A 207
 None
 1.00A 4w5oA-1mpxA:
3.7		 4w5oA-1mpxA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwj CYTIDINE
MONOPHOSPHO-N-ACETYL
NEURAMINIC ACID
SYNTHETASE

(Mus musculus) 		PF02348
(CTP_transf_3) 		4 ILE A  70
PRO A 145
ILE A 246
ASP A 245
 None
None
None
NCC  A2002 ( 4.9A)
 0.88A 4w5oA-1qwjA:
0.0		 4w5oA-1qwjA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sif UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.65A 4w5oA-1sifA:
undetectable		 4w5oA-1sifA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woc PRIMOSOMAL
REPLICATION PROTEIN
N

(Escherichia
coli) 		PF00436
(SSB) 		5 CYH A  27
ILE A  53
GLN A  28
PRO A  15
ILE A  66
 None
 1.45A 4w5oA-1wocA:
undetectable		 4w5oA-1wocA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpj HYPOTHETICAL PROTEIN

(Vibrio cholerae) 		PF08282
(Hydrolase_3) 		4 ARG A  49
ILE A  61
PRO A  67
ILE A  68
 None
 0.98A 4w5oA-1xpjA:
0.0		 4w5oA-1xpjA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2o INOSITOL
1,3,4-TRISPHOSPHATE
5/6-KINASE

(Entamoeba
histolytica) 		PF05770
(Ins134_P3_kin) 		4 ILE X 241
GLN X 190
ILE X 177
ASP X 275
 None
None
ADP  X 871 (-4.6A)
MG  X1295 (-3.2A)
 1.03A 4w5oA-1z2oX:
undetectable		 4w5oA-1z2oX:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ccz PRIMOSOMAL
REPLICATION PROTEIN
N

(Escherichia
coli) 		PF00436
(SSB) 		4 CYH A  27
ILE A  53
PRO A  15
ILE A  66
 None
 1.08A 4w5oA-2cczA:
undetectable		 4w5oA-2cczA:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fmt METHIONYL-TRNA FMET
FORMYLTRANSFERASE

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 CYH A 106
ILE A 107
PRO A 102
ILE A   7
 None
 1.04A 4w5oA-2fmtA:
3.5		 4w5oA-2fmtA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1k PANCREATIC AND
DUODENAL HOMEOBOX 1

(Mesocricetus
auratus) 		PF00046
(Homeobox) 		4 ARG A  31
ILE A  47
GLN A  50
ILE A  26
 None
 1.02A 4w5oA-2h1kA:
undetectable		 4w5oA-2h1kA:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ln7 LPXTG-SITE
TRANSPEPTIDASE
FAMILY PROTEIN

(Bacillus
anthracis) 		PF04203
(Sortase) 		4 ARG A 134
ILE A 100
PRO A 132
ASP A 130
 None
 1.08A 4w5oA-2ln7A:
undetectable		 4w5oA-2ln7A:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vkw NEURAL CELL ADHESION
MOLECULE 1,140 KDA
ISOFORM

(Homo sapiens) 		PF00041
(fn3) 		4 ILE A 622
GLN A 624
PRO A 604
ILE A 631
 None
 1.03A 4w5oA-2vkwA:
undetectable		 4w5oA-2vkwA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN

(Streptomyces
coelicolor) 		PF01497
(Peripla_BP_2) 		4 GLN A 181
PRO A 179
ILE A 169
ASP A  58
 None
 1.09A 4w5oA-2x4lA:
3.6		 4w5oA-2x4lA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycm 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01128
(IspD) 		4 CYH A 176
GLN A 238
PRO A 237
ASP A 179
 None
30A  A1306 (-3.4A)
None
None
 1.04A 4w5oA-2ycmA:
undetectable		 4w5oA-2ycmA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN

(Aequorea
victoria;
Mus musculus) 		PF00240
(ubiquitin)
PF01353
(GFP) 		4 ILE A 276
GLN A 281
ILE A 255
ASP A 284
 None
 0.86A 4w5oA-3ai5A:
undetectable		 4w5oA-3ai5A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8l UNCHARACTERIZED
PROTEIN

(Novosphingobium
aromaticivorans) 		PF13577
(SnoaL_4) 		4 ARG A   8
ILE A  11
PRO A   4
ILE A   5
 None
 1.01A 4w5oA-3b8lA:
undetectable		 4w5oA-3b8lA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3blz NTF2-LIKE PROTEIN OF
UNKNOWN FUNCTION

(Shewanella
baltica) 		PF12893
(Lumazine_bd_2) 		4 ILE A  56
GLN A  57
ILE A  63
ASP A  64
 None
 1.09A 4w5oA-3blzA:
undetectable		 4w5oA-3blzA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3byq UNCHARACTERIZED
PROTEIN DUF1185

(Bordetella
bronchiseptica) 		PF06684
(AA_synth) 		4 ILE A  37
PRO A 156
ILE A 152
ASP A 154
 None
 1.02A 4w5oA-3byqA:
undetectable		 4w5oA-3byqA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwg SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION 3

(Mus musculus) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 CYH A 251
ILE A 252
GLN A 248
ILE A 258
 None
 1.04A 4w5oA-3cwgA:
undetectable		 4w5oA-3cwgA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		4 ARG A  38
GLN A   2
PRO A 130
ASP A 125
 None
 1.04A 4w5oA-3d1jA:
3.6		 4w5oA-3d1jA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5n Q97W15_SULSO

(Sulfolobus
solfataricus) 		PF12804
(NTP_transf_3) 		4 ILE A  31
PRO A  98
ILE A 175
ASP A 174
 None
 1.08A 4w5oA-3d5nA:
undetectable		 4w5oA-3d5nA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3x BIPA

(Vibrio
parahaemolyticus) 		PF00679
(EFG_C) 		4 ARG A 146
ILE A 143
PRO A 168
ILE A 204
 None
None
MLY  A 147 ( 4.7A)
MLY  A 147 ( 4.5A)
 1.07A 4w5oA-3e3xA:
undetectable		 4w5oA-3e3xA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehm SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12741
(SusD-like) 		4 ARG A  33
ILE A  37
GLN A  32
ILE A  97
 None
 1.00A 4w5oA-3ehmA:
undetectable		 4w5oA-3ehmA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k9o UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
 0.80A 4w5oA-3k9oB:
undetectable		 4w5oA-3k9oB:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 4 GLN X 529
PRO X 488
ILE X 476
ASP X 475
 None
 1.09A 4w5oA-3kvnX:
2.3		 4w5oA-3kvnX:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0w MONOUBIQUITINATED
PROLIFERATING CELL
NUCLEAR ANTIGEN

(Saccharomyces
cerevisiae) 		PF00240
(ubiquitin)
PF02747
(PCNA_C) 		4 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
 0.66A 4w5oA-3l0wB:
undetectable		 4w5oA-3l0wB:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwr A RUBISCO-LIKE
PROTEIN

(Paraburkholderia
fungorum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ARG A 399
PRO A 162
ILE A 164
ASP A 192
 SO4  A 434 (-3.1A)
None
None
SO4  A 434 ( 4.8A)
 0.94A 4w5oA-3nwrA:
undetectable		 4w5oA-3nwrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ong UBIQUITIN-ACTIVATING
ENZYME E1-LIKE

(Saccharomyces
cerevisiae) 		no annotation 4 CYH A 442
ILE A 525
PRO A 548
ILE A 550
 None
 0.98A 4w5oA-3ongA:
undetectable		 4w5oA-3ongA:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3f RIBONUCLEASE/UBIQUIT
IN CHIMERIC PROTEIN

(Bacillus
amyloliquefaciens;
Homo sapiens) 		PF00240
(ubiquitin)
PF00545
(Ribonuclease) 		4 ILE A 148
GLN A 153
ILE A 127
ASP A 156
 None
SO4  A 191 ( 3.2A)
None
None
 0.75A 4w5oA-3q3fA:
undetectable		 4w5oA-3q3fA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8x METHIONYL-TRNA
FORMYLTRANSFERASE

(Yersinia pestis) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 CYH A 107
ILE A 108
PRO A 103
ILE A   8
 None
 1.06A 4w5oA-3r8xA:
2.8		 4w5oA-3r8xA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t02 PHOSPHONOACETATE
HYDROLASE

(Sinorhizobium
meliloti) 		PF01663
(Phosphodiest) 		4 ARG A 344
ILE A 345
PRO A  81
ILE A  86
 None
 1.04A 4w5oA-3t02A:
undetectable		 4w5oA-3t02A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A

(Homo sapiens) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		4 ILE A 263
GLN A 265
PRO A 266
ASP A  20
 None
None
None
MN  A 412 (-3.1A)
 0.84A 4w5oA-3t1iA:
undetectable		 4w5oA-3t1iA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Hoeflea
phototrophica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 CYH A 282
ILE A 254
GLN A 256
PRO A 257
 None
 1.02A 4w5oA-3t8qA:
2.3		 4w5oA-3t8qA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgw V-TYPE ATP SYNTHASE
BETA CHAIN

(Methanosarcina
mazei) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 ILE A 321
PRO A 301
ILE A 249
ASP A 248
 None
 1.05A 4w5oA-3tgwA:
undetectable		 4w5oA-3tgwA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7v BETA-GALACTOSIDASE

(Caulobacter
vibrioides) 		PF02449
(Glyco_hydro_42) 		4 GLN A 218
PRO A 215
ILE A 153
ASP A 212
 None
 1.09A 4w5oA-3u7vA:
2.9		 4w5oA-3u7vA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v47 FLAGELLIN

(Salmonella
enterica) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C) 		4 ILE C 115
GLN C 116
ILE C 122
ASP C 123
 None
 1.04A 4w5oA-3v47C:
undetectable		 4w5oA-3v47C:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vdz UBIQUITIN-40S
RIBOSOMAL PROTEIN
S27A

(Homo sapiens;
synthetic
construct) 		PF00240
(ubiquitin) 		4 ILE A 144
GLN A 149
ILE A 123
ASP A 152
 None
None
None
SO4  A 204 (-3.5A)
 0.97A 4w5oA-3vdzA:
undetectable		 4w5oA-3vdzA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl4 UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF02585
(PIG-L) 		4 ILE A 223
GLN A 218
ILE A  46
ASP A  43
 HEZ  A 315 ( 4.3A)
TAM  A 309 ( 4.0A)
TAM  A 309 (-4.9A)
CD  A 301 ( 2.1A)
 0.98A 4w5oA-3wl4A:
2.5		 4w5oA-3wl4A:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a35 MITOCHONDRIAL
ENOLASE SUPERFAMILY
MEMBER 1

(Homo sapiens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 316
GLN A 319
ILE A 159
ASP A 161
 None
 1.02A 4w5oA-4a35A:
undetectable		 4w5oA-4a35A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ast ALDO-KETO REDUCTASE
AKR14A1

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		4 CYH A 219
ILE A 191
GLN A 193
PRO A 194
 None
 1.03A 4w5oA-4astA:
3.1		 4w5oA-4astA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au0 EXOGLUCANASE 2

(Trichoderma
reesei) 		PF01341
(Glyco_hydro_6) 		4 CYH A 245
ILE A 246
PRO A 172
ILE A 187
 None
 0.98A 4w5oA-4au0A:
undetectable		 4w5oA-4au0A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Ochrobactrum
sp. T63) 		PF00561
(Abhydrolase_1) 		4 ILE A 203
GLN A 200
PRO A 128
ILE A 123
 None
 0.86A 4w5oA-4g8dA:
2.2		 4w5oA-4g8dA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gb7 6-AMINOHEXANOATE-DIM
ER HYDROLASE

(Bacillus
anthracis) 		PF00144
(Beta-lactamase) 		4 ILE A 325
GLN A 324
PRO A 327
ILE A 330
 None
 1.09A 4w5oA-4gb7A:
undetectable		 4w5oA-4gb7A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfq MUTT/NUDIX FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF00293
(NUDIX)
PF12535
(Nudix_N) 		4 CYH A  83
ILE A  82
PRO A  96
ILE A 114
 None
None
SO4  A 304 ( 4.9A)
None
 0.97A 4w5oA-4hfqA:
undetectable		 4w5oA-4hfqA:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i5u CHIMERIC CEL6A

(Humicola
insolens;
Trichoderma
reesei;
Chaetomium
thermophilum) 		PF01341
(Glyco_hydro_6) 		4 CYH A 246
ILE A 247
PRO A 173
ILE A 188
 ACT  A 502 ( 3.9A)
None
None
None
 0.98A 4w5oA-4i5uA:
undetectable		 4w5oA-4i5uA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ig9 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		4 CYH A 362
GLN A 345
PRO A 447
ILE A 451
 None
 0.98A 4w5oA-4ig9A:
2.2		 4w5oA-4ig9A:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ii2 UBIQUITIN-60S
RIBOSOMAL PROTEIN
L40

(Schizosaccharomyces
pombe) 		PF00240
(ubiquitin) 		4 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
EDO  B 101 (-2.8A)
None
None
 0.79A 4w5oA-4ii2B:
undetectable		 4w5oA-4ii2B:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ii3 UBIQUITIN-60S
RIBOSOMAL PROTEIN
L40

(Schizosaccharomyces
pombe) 		PF00240
(ubiquitin) 		4 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
 0.75A 4w5oA-4ii3B:
undetectable		 4w5oA-4ii3B:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ios BPP

(Lactococcus
phage TP901-1) 		no annotation 4 CYH A 119
ILE A 136
PRO A 161
ASP A 163
 None
 1.06A 4w5oA-4iosA:
undetectable		 4w5oA-4iosA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4isb LONG CHAIN FATTY
ACID COA LIGASE
FADD10

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A 361
PRO A 363
ILE A 400
ASP A 401
 None
 1.08A 4w5oA-4isbA:
1.8		 4w5oA-4isbA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT
ELECTRON TRANSFER
FLAVOPROTEIN
ALPHA/BETA-SUBUNIT

(Acidaminococcus
fermentans;
Acidaminococcus
fermentans) 		PF00766
(ETF_alpha)
PF01012
(ETF)
PF01012
(ETF) 		4 ARG A 204
CYH A 202
ILE A 203
ASP B 159
 None
 0.99A 4w5oA-4kpuA:
2.7		 4w5oA-4kpuA:
17.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		7 ARG A 686
CYH A 689
ILE A 690
GLN A 697
PRO A 698
ILE A 700
ASP A 769
 None
 0.25A 4w5oA-4krfA:
59.7		 4w5oA-4krfA:
82.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9d ADENYLOSUCCINATE
SYNTHETASE

(Bacillus
anthracis) 		PF00709
(Adenylsucc_synt) 		4 ILE A 132
GLN A 223
ILE A 229
ASP A 228
 AMP  A 501 ( 4.3A)
AMP  A 501 (-4.1A)
None
None
 1.02A 4w5oA-4m9dA:
undetectable		 4w5oA-4m9dA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovq TRAP DICARBOXYLATE
ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Roseobacter
denitrificans) 		PF03480
(DctP) 		4 CYH A 236
ILE A 237
PRO A 138
ILE A 136
 None
 1.09A 4w5oA-4ovqA:
undetectable		 4w5oA-4ovqA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pqq MUSKELIN

(Mus musculus) 		PF06588
(Muskelin_N) 		4 CYH A 164
GLN A 162
ILE A 160
ASP A 157
 None
 1.01A 4w5oA-4pqqA:
undetectable		 4w5oA-4pqqA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx7 CLASS I CHITINASE

(Vigna
unguiculata) 		PF00182
(Glyco_hydro_19) 		4 ILE A 163
PRO A 184
ILE A 181
ASP A 179
 None
 1.01A 4w5oA-4tx7A:
undetectable		 4w5oA-4tx7A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1g UNCHARACTERIZED
PROTEIN SAV1875

(Staphylococcus
aureus) 		PF01965
(DJ-1_PfpI) 		4 ILE A 112
GLN A 109
PRO A 108
ILE A  70
 None
None
CSO  A 105 ( 4.4A)
None
 1.05A 4w5oA-4y1gA:
undetectable		 4w5oA-4y1gA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2

(Homo sapiens) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 ARG A 440
ILE A 441
PRO A 223
ILE A 228
 GOL  A 912 (-3.5A)
None
None
None
 0.88A 4w5oA-4zg7A:
undetectable		 4w5oA-4zg7A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zzh NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		4 CYH A 362
GLN A 345
PRO A 447
ILE A 451
 None
 1.00A 4w5oA-4zzhA:
undetectable		 4w5oA-4zzhA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b83 TETRA UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A 120
GLN A 125
ILE A  99
ASP A 128
 None
 0.77A 4w5oA-5b83A:
undetectable		 4w5oA-5b83A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b83 TETRA UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A 196
GLN A 201
ILE A 175
ASP A 204
 None
 0.76A 4w5oA-5b83A:
undetectable		 4w5oA-5b83A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b83 TETRA UBIQUITIN

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A 272
GLN A 277
ILE A 251
ASP A 280
 None
 0.69A 4w5oA-5b83A:
undetectable		 4w5oA-5b83A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d9a RNA-DIRECTED RNA
POLYMERASE CATALYTIC
SUBUNIT

(Influenza C
virus) 		PF00602
(Flu_PB1) 		4 CYH B 169
ILE B 173
PRO B 252
ILE B 256
 None
 1.01A 4w5oA-5d9aB:
undetectable		 4w5oA-5d9aB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dtu PRP28

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ARG A 304
ILE A 307
GLN A 303
ILE A 264
 None
None
ADP  A 801 (-2.8A)
None
 0.98A 4w5oA-5dtuA:
undetectable		 4w5oA-5dtuA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0o COHESIN SUBUNIT
PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P

(Lachancea
thermotolerans) 		no annotation 4 ARG A 450
ILE A 454
ILE A 494
ASP A 496
 None
 1.08A 4w5oA-5f0oA:
undetectable		 4w5oA-5f0oA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gju ATP-DEPENDENT RNA
HELICASE DEAD

(Escherichia
coli) 		PF00270
(DEAD) 		4 CYH A  36
ILE A  37
GLN A  33
ILE A 210
 None
None
AMP  A 301 (-2.4A)
None
 0.94A 4w5oA-5gjuA:
undetectable		 4w5oA-5gjuA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h07 POLYUBIQUITIN-C

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 1.05A 4w5oA-5h07A:
undetectable		 4w5oA-5h07A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h07 POLYUBIQUITIN-C

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A 144
GLN A 149
ILE A 123
ASP A 152
 None
 0.87A 4w5oA-5h07A:
undetectable		 4w5oA-5h07A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h07 POLYUBIQUITIN-C

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A 244
GLN A 249
ILE A 223
ASP A 252
 None
 0.90A 4w5oA-5h07A:
undetectable		 4w5oA-5h07A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5c MITOCHONDRIAL
DISTRIBUTION AND
MORPHOLOGY PROTEIN
12

(Kluyveromyces
lactis) 		no annotation 4 ARG A  11
ILE A  10
PRO A  51
ASP A  99
 None
 0.99A 4w5oA-5h5cA:
undetectable		 4w5oA-5h5cA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpt UBIQUITIN VARIANT
P2.3

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
 0.78A 4w5oA-5hptB:
undetectable		 4w5oA-5hptB:
6.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvn 3-DEHYDROQUINATE
SYNTHASE

(Francisella
tularensis) 		PF01761
(DHQ_synthase) 		4 ARG A 176
ILE A 179
GLN A 175
PRO A 174
 None
 1.04A 4w5oA-5hvnA:
3.9		 4w5oA-5hvnA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME

(Brucella
melitensis) 		PF01053
(Cys_Met_Meta_PP) 		4 ARG A 197
PRO A 211
ILE A 213
ASP A 233
 None
 0.85A 4w5oA-5ijgA:
2.9		 4w5oA-5ijgA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		4 ILE A 102
GLN A 103
ILE A 109
ASP A 110
 None
 1.04A 4w5oA-5jboA:
2.3		 4w5oA-5jboA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mac RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE-OXYGENAS
E TYPE III

(Methanococcoides
burtonii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ARG A 389
ILE A 382
ILE A 362
ASP A 366
 None
None
None
MG  A 503 (-2.2A)
 1.00A 4w5oA-5macA:
undetectable		 4w5oA-5macA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nsj PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX

(Whitewater
Arroyo
mammarenavirus) 		no annotation 4 ILE A 162
GLN A 160
PRO A 159
ILE A 177
 None
 1.08A 4w5oA-5nsjA:
undetectable		 4w5oA-5nsjA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o76 UBV.PCBL UBIQUITIN
VARIANT

(Homo sapiens) 		no annotation 4 ILE E  44
GLN E  49
ILE E  23
ASP E  52
 None
 0.71A 4w5oA-5o76E:
undetectable		 4w5oA-5o76E:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucl POLYUBIQUITIN-B

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.93A 4w5oA-5uclA:
undetectable		 4w5oA-5uclA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uju NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		4 ILE A 452
GLN A 347
PRO A 346
ILE A 349
 None
 1.06A 4w5oA-5ujuA:
5.3		 4w5oA-5ujuA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um6 UBIQUITIN-ACTIVATING
ENZYME E1 1

(Schizosaccharomyces
pombe) 		PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB) 		4 ILE A 901
PRO A 904
ILE A 916
ASP A 914
 None
 0.89A 4w5oA-5um6A:
2.1		 4w5oA-5um6A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v5g UBIQUITIN VARIANT
CC.4

(synthetic
construct) 		PF00240
(ubiquitin) 		4 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
EDO  B 101 ( 4.1A)
None
EDO  B 101 (-2.5A)
 0.71A 4w5oA-5v5gB:
undetectable		 4w5oA-5v5gB:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6a ME.2

(Homo sapiens) 		PF00240
(ubiquitin) 		4 ILE B  44
GLN B  49
ILE B  23
ASP B  52
 None
 0.80A 4w5oA-5v6aB:
undetectable		 4w5oA-5v6aB:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6t PLEXIN-D1

(Mus musculus) 		PF08337
(Plexin_cytopl) 		4 CYH A1806
ILE A1803
PRO A1768
ILE A1725
 None
 1.03A 4w5oA-5v6tA:
undetectable		 4w5oA-5v6tA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vix POLYUBIQUITIN

(Naegleria
gruberi) 		PF00240
(ubiquitin) 		4 ILE A  44
GLN A  49
ILE A  23
ASP A  52
 None
 0.85A 4w5oA-5vixA:
undetectable		 4w5oA-5vixA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vix POLYUBIQUITIN

(Naegleria
gruberi) 		PF00240
(ubiquitin) 		4 ILE A 120
GLN A 125
ILE A  99
ASP A 128
 NO3  A 201 (-4.5A)
None
None
None
 0.72A 4w5oA-5vixA:
undetectable		 4w5oA-5vixA:
13.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 5 CYH A 692
ILE A 693
PRO A 701
ILE A 703
ASP A 772
 None
 0.50A 4w5oA-5vm9A:
55.6		 4w5oA-5vm9A:
79.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 7 ARG A 688
CYH A 691
ILE A 692
GLN A 699
PRO A 700
ILE A 702
ASP A 771
 None
 0.66A 4w5oA-5weaA:
58.7		 4w5oA-5weaA:
99.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0z FLAGELLAR MOTOR
SWITCH PROTEIN
(FLIM)

(Helicobacter
pylori) 		PF02154
(FliM) 		4 CYH E 217
ILE E 216
PRO E 219
ILE E 191
 None
 0.94A 4w5oA-5x0zE:
undetectable		 4w5oA-5x0zE:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xct VH(S112C)-SARAH
CHIMERA

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF11629
(Mst1_SARAH) 		4 ARG A 154
GLN A 155
PRO A 156
ILE A 157
 None
 1.09A 4w5oA-5xctA:
undetectable		 4w5oA-5xctA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xcu VH(S112C)-SARAH
CHIMERA,VH(S112C)-SA
RAH CHIMERA

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF11629
(Mst1_SARAH) 		4 ARG A 154
GLN A 155
PRO A 156
ILE A 157
 None
 1.06A 4w5oA-5xcuA:
undetectable		 4w5oA-5xcuA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z06 BDI_3064 PROTEIN

(Parabacteroides
distasonis) 		no annotation 4 ARG A 586
ILE A 589
GLN A 585
ILE A 583
 None
 0.79A 4w5oA-5z06A:
undetectable		 4w5oA-5z06A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zc2 -

(-) 		no annotation 4 ARG B 240
ILE B  90
GLN B 239
ASP B 237
 None
 1.07A 4w5oA-5zc2B:
undetectable		 4w5oA-5zc2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 GLN A2222
PRO A2223
ILE A2224
ASP A2326
 None
 1.02A 4w5oA-6b3rA:
undetectable		 4w5oA-6b3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3

(Homo sapiens) 		no annotation 4 ARG A 455
ILE A 456
PRO A 218
ILE A 223
 None
 0.93A 4w5oA-6c01A:
undetectable		 4w5oA-6c01A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw PROBABLE
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
MBHJ

(Pyrococcus
furiosus) 		no annotation 4 CYH J  38
ILE J  40
PRO J 134
ILE J 139
 SF4  J 201 (-3.0A)
None
None
None
 1.04A 4w5oA-6cfwJ:
undetectable		 4w5oA-6cfwJ:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 4 ARG A1096
ILE A1117
GLN A1111
ILE A1023
 None
 1.05A 4w5oA-6eojA:
undetectable		 4w5oA-6eojA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gng -

(-) 		no annotation 4 ILE A 483
GLN A 242
PRO A 243
ILE A 245
 None
 1.07A 4w5oA-6gngA:
2.2		 4w5oA-6gngA:
undetectable