SIMILAR PATTERNS OF AMINO ACIDS FOR 4W5N_A_IPHA903
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bg6 | N-(1-D-CARBOXYLETHYL)-L-NORVALINEDEHYDROGENASE (Arthrobactersp. 1C) |
PF02317(Octopine_DH)PF02558(ApbA) | 4 | TYR A 183THR A 135GLY A 133LEU A 104 | None | 1.09A | 4w5nA-1bg6A:1.6 | 4w5nA-1bg6A:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fob | BETA-1,4-GALACTANASE (Aspergillusaculeatus) |
PF07745(Glyco_hydro_53) | 4 | TYR A 151THR A 148GLY A 140LEU A 180 | None | 1.02A | 4w5nA-1fobA:1.4 | 4w5nA-1fobA:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lrw | METHANOLDEHYDROGENASESUBUNIT 1 (Paracoccusdenitrificans) |
PF01011(PQQ)PF13360(PQQ_2) | 4 | TYR A 183THR A 185GLY A 172LEU A 158 | None | 1.29A | 4w5nA-1lrwA:0.0 | 4w5nA-1lrwA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n7u | ADSORPTION PROTEINP2 (Salmonellavirus PRD1) |
PF09214(Prd1-P2) | 4 | TYR A 44THR A 360GLY A 48LEU A 35 | None | 1.04A | 4w5nA-1n7uA:0.0 | 4w5nA-1n7uA:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ndg | IMMUNOGLOBULIN GAMMA1 CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 4 | TYR B 359THR B 357GLY B 349LEU B 380 | None | 1.28A | 4w5nA-1ndgB:undetectable | 4w5nA-1ndgB:12.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qnz | 0.5B ANTIBODY (HEAVYCHAIN) (Mus musculus) |
PF07686(V-set) | 4 | TYR H 172THR H 170GLY H 161LEU H 193 | None | 1.42A | 4w5nA-1qnzH:undetectable | 4w5nA-1qnzH:9.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qr0 | 4'-PHOSPHOPANTETHEINYL TRANSFERASE SFP (Bacillussubtilis) |
PF01648(ACPS) | 4 | TYR A 4THR A 216GLY A 5LEU A 223 | None | 1.31A | 4w5nA-1qr0A:0.3 | 4w5nA-1qr0A:13.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w6s | METHANOLDEHYDROGENASESUBUNIT 1 (Methylobacteriumextorquens) |
PF01011(PQQ)PF13360(PQQ_2) | 4 | TYR A 183THR A 185GLY A 172LEU A 158 | None | 1.23A | 4w5nA-1w6sA:0.0 | 4w5nA-1w6sA:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a39 | ENDOGLUCANASE I (Humicolainsolens) |
PF00840(Glyco_hydro_7) | 4 | TYR A 323THR A 214GLY A 331LEU A 280 | None | 1.33A | 4w5nA-2a39A:0.0 | 4w5nA-2a39A:18.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fk5 | FUCULOSE-1-PHOSPHATEALDOLASE (Thermusthermophilus) |
PF00596(Aldolase_II) | 4 | TYR A 114THR A 175GLY A 111LEU A 109 | None | 1.34A | 4w5nA-2fk5A:undetectable | 4w5nA-2fk5A:14.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hcs | RNA-DIRECTED RNAPOLYMERASE (NS5) (West Nile virus) |
PF00972(Flavi_NS5) | 4 | TYR A 610THR A 614GLY A 508LEU A 512 | None | 1.47A | 4w5nA-2hcsA:undetectable | 4w5nA-2hcsA:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lhf | OUTER MEMBRANEPROTEIN H1 (Pseudomonasaeruginosa) |
PF13505(OMP_b-brl) | 4 | TYR A 172THR A 9GLY A 174LEU A 128 | None | 1.34A | 4w5nA-2lhfA:undetectable | 4w5nA-2lhfA:11.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ood | BLR3880 PROTEIN (Bradyrhizobiumdiazoefficiens) |
PF01979(Amidohydro_1) | 4 | TYR A 259THR A 233GLY A 271LEU A 277 | None | 1.13A | 4w5nA-2oodA:undetectable | 4w5nA-2oodA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rkj | TYROSYL-TRNASYNTHETASE (Neurosporacrassa) |
PF00579(tRNA-synt_1b) | 4 | TYR A 274THR A 80GLY A 311LEU A 281 | None | 1.38A | 4w5nA-2rkjA:undetectable | 4w5nA-2rkjA:17.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yhe | SEC-ALKYL SULFATASE (Pseudomonas sp.DSM 6611) |
PF00753(Lactamase_B)PF14863(Alkyl_sulf_dimr)PF14864(Alkyl_sulf_C) | 4 | TYR A 177THR A 149GLY A 186LEU A 261 | None | 1.23A | 4w5nA-2yheA:undetectable | 4w5nA-2yheA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ai7 | XYLULOSE-5-PHOSPHATE/FRUCTOSE-6-PHOSPHATE PHOSPHOKETOLASE (Bifidobacteriumlongum) |
PF03894(XFP)PF09363(XFP_C)PF09364(XFP_N) | 4 | TYR A 107THR A 113GLY A 110LEU A 361 | None | 1.13A | 4w5nA-3ai7A:2.4 | 4w5nA-3ai7A:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3b9n | ALKANE MONOOXYGENASE (Geobacillusthermodenitrificans) |
PF00296(Bac_luciferase) | 4 | TYR A 66THR A 72GLY A 307LEU A 305 | None | 0.87A | 4w5nA-3b9nA:undetectable | 4w5nA-3b9nA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j7a | 40S RIBOSOMALPROTEIN US5 (Plasmodiumfalciparum) |
PF00333(Ribosomal_S5)PF03719(Ribosomal_S5_C) | 4 | TYR G 234THR G 233GLY G 235LEU G 241 | None | 1.39A | 4w5nA-3j7aG:undetectable | 4w5nA-3j7aG:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lv4 | GLYCOSIDE HYDROLASEYXIA (Bacilluslicheniformis) |
PF04616(Glyco_hydro_43)PF16369(GH43_C) | 4 | TYR A 313THR A 336GLY A 317LEU A 332 | None | 0.95A | 4w5nA-3lv4A:undetectable | 4w5nA-3lv4A:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mlw | HUMAN MONOCLONALANTI-HIV-1 GP120 V3ANTIBODY 1006-15DFAB HEAVY CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | TYR H 59THR H 57GLY H 49LEU H 80 | None | 1.40A | 4w5nA-3mlwH:undetectable | 4w5nA-3mlwH:13.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n6n | RNA-DEPENDENT RNAPOLYMERASE (Enterovirus A) |
PF00680(RdRP_1) | 4 | TYR A 154THR A 272GLY A 268LEU A 187 | None | 1.43A | 4w5nA-3n6nA:undetectable | 4w5nA-3n6nA:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tgl | TRIACYL-GLYCEROLACYLHYDROLASE (Rhizomucormiehei) |
PF01764(Lipase_3) | 4 | TYR A 99THR A 105GLY A 180LEU A 151 | None | 1.08A | 4w5nA-3tglA:undetectable | 4w5nA-3tglA:15.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ui7 | CAMP ANDCAMP-INHIBITED CGMP3',5'-CYCLICPHOSPHODIESTERASE10A (Homo sapiens) |
PF00233(PDEase_I) | 4 | TYR A 638THR A 671GLY A 667LEU A 645 | None | 1.04A | 4w5nA-3ui7A:undetectable | 4w5nA-3ui7A:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wq4 | BETA-PRIMEVEROSIDASE (Camelliasinensis) |
PF00232(Glyco_hydro_1) | 4 | TYR A 460THR A 462GLY A 46LEU A 505 | None | 1.41A | 4w5nA-3wq4A:2.3 | 4w5nA-3wq4A:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zl8 | UDP-N-ACETYLMURAMOYL-TRIPEPTIDE--D-ALANYL-D-ALANINE LIGASE (Thermotogamaritima) |
PF01225(Mur_ligase)PF02875(Mur_ligase_C)PF08245(Mur_ligase_M) | 4 | TYR A 233THR A 238GLY A 236LEU A 303 | None | 0.96A | 4w5nA-3zl8A:2.0 | 4w5nA-3zl8A:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bf7 | ARABINOGALACTANENDO-1,4-BETA-GALACTOSIDASE A (Aspergillusnidulans) |
PF07745(Glyco_hydro_53) | 4 | TYR A 151THR A 148GLY A 140LEU A 180 | None | 1.02A | 4w5nA-4bf7A:2.6 | 4w5nA-4bf7A:18.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cot | EXTRACELLULARENDO-ALPHA-(1->5)-L-ARABINANASE 2 (Bacillussubtilis) |
PF04616(Glyco_hydro_43)PF16369(GH43_C) | 4 | TYR A 313THR A 336GLY A 317LEU A 332 | None | 0.96A | 4w5nA-4cotA:undetectable | 4w5nA-4cotA:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e09 | PLASMID PARTITIONINGPROTEIN PARF (Escherichiacoli) |
PF01656(CbiA) | 4 | TYR A 172THR A 17GLY A 14LEU A 136 | ACP A 301 (-3.9A)ACP A 301 (-3.4A)ACP A 301 (-3.2A)None | 1.49A | 4w5nA-4e09A:4.0 | 4w5nA-4e09A:12.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fmg | VP1 (Humanpolyomavirus 5) |
PF00718(Polyoma_coat) | 4 | TYR A 79THR A 78GLY A 304LEU A 138 | None | 0.95A | 4w5nA-4fmgA:undetectable | 4w5nA-4fmgA:15.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4laq | SINGLE HEAVY CHAINVARIABLE FRAGMENT (Mus musculus) |
PF07686(V-set) | 4 | TYR H 59THR H 57GLY H 49LEU H 80 | None | 1.36A | 4w5nA-4laqH:undetectable | 4w5nA-4laqH:7.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tqo | METHANOLDEHYDROGENASEPROTEIN, LARGESUBUNIT (Methylococcuscapsulatus) |
no annotation | 4 | TYR B 211THR B 213GLY B 200LEU B 186 | None | 1.28A | 4w5nA-4tqoB:undetectable | 4w5nA-4tqoB:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ut1 | FLAGELLARHOOK-ASSOCIATEDPROTEIN (Burkholderiapseudomallei) |
PF06429(Flg_bbr_C) | 4 | TYR A 365THR A 361GLY A 401LEU A 404 | None | 1.50A | 4w5nA-4ut1A:undetectable | 4w5nA-4ut1A:21.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y1b | ANTE (Streptomycessp. NRRL 2288) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | TYR A 64THR A 326GLY A 324LEU A 214 | NAP A 501 (-3.2A)NAP A 501 (-3.6A)NAP A 501 ( 3.3A)NAP A 501 (-3.8A) | 1.16A | 4w5nA-4y1bA:undetectable | 4w5nA-4y1bA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yue | S4B6 FAB HEAVY CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 4 | TYR H 63THR H 61GLY H 52LEU H 84 | None | 1.43A | 4w5nA-4yueH:undetectable | 4w5nA-4yueH:14.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z9r | OMEGA-3POLYUNSATURATEDFATTY ACID SYNTHASESUBUNIT PFAD (Shewanellaoneidensis) |
PF03060(NMO) | 4 | TYR A 104THR A 334GLY A 107LEU A 118 | NoneNoneFMN A 602 (-3.2A)None | 1.31A | 4w5nA-4z9rA:undetectable | 4w5nA-4z9rA:20.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ayu | IG VH,ANTI-LYSOZYME (Mus musculus) |
PF07686(V-set) | 4 | TYR H 59THR H 57GLY H 49LEU H 80 | None | 1.33A | 4w5nA-5ayuH:undetectable | 4w5nA-5ayuH:8.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b2g | ENDOLYSIN,CLAUDIN-4 (Homo sapiens;Escherichiavirus T4) |
PF00822(PMP22_Claudin)PF00959(Phage_lysozyme) | 4 | TYR A1018THR A1026GLY A1028LEU A1013 | None | 1.30A | 4w5nA-5b2gA:undetectable | 4w5nA-5b2gA:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f0o | COHESIN SUBUNITPDS5,KLTH0D07062P,KLTH0D07062P,KLTH0D07062P,COHESIN SUBUNIT PDS5,KLTH0D07062P,KLTH0D07062P,KLTH0D07062P,COHESIN SUBUNIT PDS5,KLTH0D07062P,KLTH0D07062P,KLTH0D07062P,COHESIN SUBUNIT PDS5,KLTH0D07062P,KLTH0D07062P (Lachanceathermotolerans) |
no annotation | 4 | TYR A 268THR A 301GLY A 298LEU A 322 | None | 1.39A | 4w5nA-5f0oA:undetectable | 4w5nA-5f0oA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hkj | COMPLEMENT C1QSUBCOMPONENT SUBUNITA,COMPLEMENT C1QSUBCOMPONENT SUBUNITC,COMPLEMENT C1QSUBCOMPONENT SUBUNITB (Homo sapiens) |
PF00386(C1q) | 4 | TYR A 326THR A 328GLY A 401LEU A 267 | None | 1.29A | 4w5nA-5hkjA:undetectable | 4w5nA-5hkjA:19.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hp6 | EXTRACELLULARARABINANASE (Geobacillusstearothermophilus) |
PF04616(Glyco_hydro_43)PF13385(Laminin_G_3)PF16369(GH43_C) | 4 | TYR A 390THR A 413GLY A 394LEU A 409 | None | 0.96A | 4w5nA-5hp6A:undetectable | 4w5nA-5hp6A:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i92 | GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE (Pseudomonasaeruginosa) |
PF00202(Aminotran_3) | 4 | TYR A 55THR A 403GLY A 401LEU A 357 | NoneNoneEDO A 502 (-3.7A)EDO A 502 (-3.8A) | 1.18A | 4w5nA-5i92A:2.5 | 4w5nA-5i92A:19.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ijv | BOVINE FAB E03 HEAVYCHAIN (Bos taurus) |
no annotation | 4 | TYR H 59THR H 57GLY H 49LEU H 80 | None | 1.12A | 4w5nA-5ijvH:undetectable | 4w5nA-5ijvH:14.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5l8s | AMINO ACYL PEPTIDASE (Sporosarcinapsychrophila) |
PF00326(Peptidase_S9) | 4 | TYR A 171THR A 157GLY A 152LEU A 148 | None | 1.48A | 4w5nA-5l8sA:4.2 | 4w5nA-5l8sA:21.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5sx4 | PANITUMUMAB FABHEAVY CHAIN (Homo sapiens) |
no annotation | 4 | TYR J 61THR J 59GLY J 51LEU J 82 | None | 1.34A | 4w5nA-5sx4J:undetectable | 4w5nA-5sx4J:12.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tjf | ALLOPHYCOCYANINALPHA SUBUNIT (Gracilariachilensis) |
PF00502(Phycobilisome) | 4 | TYR A 116THR A 121GLY A 125LEU A 85 | CYC A 201 (-4.6A)CYC A 201 (-3.7A)CYC A 201 (-3.0A)CYC A 201 ( 3.6A) | 1.25A | 4w5nA-5tjfA:undetectable | 4w5nA-5tjfA:12.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tmh | POLYPROTEIN (Zika virus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 4 | TYR A 609THR A 613GLY A 507LEU A 511 | None | 1.42A | 4w5nA-5tmhA:undetectable | 4w5nA-5tmhA:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wea | PROTEIN ARGONAUTE-2 (Homo sapiens) |
no annotation | 4 | TYR A 174THR A 183GLY A 201LEU A 382 | None | 0.47A | 4w5nA-5weaA:60.4 | 4w5nA-5weaA:undetectable |