SIMILAR PATTERNS OF AMINO ACIDS FOR 4W5N_A_IPHA903

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg6 N-(1-D-CARBOXYLETHYL
)-L-NORVALINE
DEHYDROGENASE


(Arthrobacter
sp. 1C)
PF02317
(Octopine_DH)
PF02558
(ApbA)
4 TYR A 183
THR A 135
GLY A 133
LEU A 104
None
1.09A 4w5nA-1bg6A:
1.6
4w5nA-1bg6A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fob BETA-1,4-GALACTANASE

(Aspergillus
aculeatus)
PF07745
(Glyco_hydro_53)
4 TYR A 151
THR A 148
GLY A 140
LEU A 180
None
1.02A 4w5nA-1fobA:
1.4
4w5nA-1fobA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrw METHANOL
DEHYDROGENASE
SUBUNIT 1


(Paracoccus
denitrificans)
PF01011
(PQQ)
PF13360
(PQQ_2)
4 TYR A 183
THR A 185
GLY A 172
LEU A 158
None
1.29A 4w5nA-1lrwA:
0.0
4w5nA-1lrwA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7u ADSORPTION PROTEIN
P2


(Salmonella
virus PRD1)
PF09214
(Prd1-P2)
4 TYR A  44
THR A 360
GLY A  48
LEU A  35
None
1.04A 4w5nA-1n7uA:
0.0
4w5nA-1n7uA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ndg IMMUNOGLOBULIN GAMMA
1 CHAIN


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 TYR B 359
THR B 357
GLY B 349
LEU B 380
None
1.28A 4w5nA-1ndgB:
undetectable
4w5nA-1ndgB:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qnz 0.5B ANTIBODY (HEAVY
CHAIN)


(Mus musculus)
PF07686
(V-set)
4 TYR H 172
THR H 170
GLY H 161
LEU H 193
None
1.42A 4w5nA-1qnzH:
undetectable
4w5nA-1qnzH:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qr0 4'-PHOSPHOPANTETHEIN
YL TRANSFERASE SFP


(Bacillus
subtilis)
PF01648
(ACPS)
4 TYR A   4
THR A 216
GLY A   5
LEU A 223
None
1.31A 4w5nA-1qr0A:
0.3
4w5nA-1qr0A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1


(Methylobacterium
extorquens)
PF01011
(PQQ)
PF13360
(PQQ_2)
4 TYR A 183
THR A 185
GLY A 172
LEU A 158
None
1.23A 4w5nA-1w6sA:
0.0
4w5nA-1w6sA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a39 ENDOGLUCANASE I

(Humicola
insolens)
PF00840
(Glyco_hydro_7)
4 TYR A 323
THR A 214
GLY A 331
LEU A 280
None
1.33A 4w5nA-2a39A:
0.0
4w5nA-2a39A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE


(Thermus
thermophilus)
PF00596
(Aldolase_II)
4 TYR A 114
THR A 175
GLY A 111
LEU A 109
None
1.34A 4w5nA-2fk5A:
undetectable
4w5nA-2fk5A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcs RNA-DIRECTED RNA
POLYMERASE (NS5)


(West Nile virus)
PF00972
(Flavi_NS5)
4 TYR A 610
THR A 614
GLY A 508
LEU A 512
None
1.47A 4w5nA-2hcsA:
undetectable
4w5nA-2hcsA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lhf OUTER MEMBRANE
PROTEIN H1


(Pseudomonas
aeruginosa)
PF13505
(OMP_b-brl)
4 TYR A 172
THR A   9
GLY A 174
LEU A 128
None
1.34A 4w5nA-2lhfA:
undetectable
4w5nA-2lhfA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens)
PF01979
(Amidohydro_1)
4 TYR A 259
THR A 233
GLY A 271
LEU A 277
None
1.13A 4w5nA-2oodA:
undetectable
4w5nA-2oodA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkj TYROSYL-TRNA
SYNTHETASE


(Neurospora
crassa)
PF00579
(tRNA-synt_1b)
4 TYR A 274
THR A  80
GLY A 311
LEU A 281
None
1.38A 4w5nA-2rkjA:
undetectable
4w5nA-2rkjA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611)
PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C)
4 TYR A 177
THR A 149
GLY A 186
LEU A 261
None
1.23A 4w5nA-2yheA:
undetectable
4w5nA-2yheA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE


(Bifidobacterium
longum)
PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N)
4 TYR A 107
THR A 113
GLY A 110
LEU A 361
None
1.13A 4w5nA-3ai7A:
2.4
4w5nA-3ai7A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9n ALKANE MONOOXYGENASE

(Geobacillus
thermodenitrificans)
PF00296
(Bac_luciferase)
4 TYR A  66
THR A  72
GLY A 307
LEU A 305
None
0.87A 4w5nA-3b9nA:
undetectable
4w5nA-3b9nA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7a 40S RIBOSOMAL
PROTEIN US5


(Plasmodium
falciparum)
PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C)
4 TYR G 234
THR G 233
GLY G 235
LEU G 241
None
1.39A 4w5nA-3j7aG:
undetectable
4w5nA-3j7aG:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lv4 GLYCOSIDE HYDROLASE
YXIA


(Bacillus
licheniformis)
PF04616
(Glyco_hydro_43)
PF16369
(GH43_C)
4 TYR A 313
THR A 336
GLY A 317
LEU A 332
None
0.95A 4w5nA-3lv4A:
undetectable
4w5nA-3lv4A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mlw HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 1006-15D
FAB HEAVY CHAIN


(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
4 TYR H  59
THR H  57
GLY H  49
LEU H  80
None
1.40A 4w5nA-3mlwH:
undetectable
4w5nA-3mlwH:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6n RNA-DEPENDENT RNA
POLYMERASE


(Enterovirus A)
PF00680
(RdRP_1)
4 TYR A 154
THR A 272
GLY A 268
LEU A 187
None
1.43A 4w5nA-3n6nA:
undetectable
4w5nA-3n6nA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE


(Rhizomucor
miehei)
PF01764
(Lipase_3)
4 TYR A  99
THR A 105
GLY A 180
LEU A 151
None
1.08A 4w5nA-3tglA:
undetectable
4w5nA-3tglA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ui7 CAMP AND
CAMP-INHIBITED CGMP
3',5'-CYCLIC
PHOSPHODIESTERASE
10A


(Homo sapiens)
PF00233
(PDEase_I)
4 TYR A 638
THR A 671
GLY A 667
LEU A 645
None
1.04A 4w5nA-3ui7A:
undetectable
4w5nA-3ui7A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq4 BETA-PRIMEVEROSIDASE

(Camellia
sinensis)
PF00232
(Glyco_hydro_1)
4 TYR A 460
THR A 462
GLY A  46
LEU A 505
None
1.41A 4w5nA-3wq4A:
2.3
4w5nA-3wq4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zl8 UDP-N-ACETYLMURAMOYL
-TRIPEPTIDE--D-ALANY
L-D-ALANINE LIGASE


(Thermotoga
maritima)
PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
4 TYR A 233
THR A 238
GLY A 236
LEU A 303
None
0.96A 4w5nA-3zl8A:
2.0
4w5nA-3zl8A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A


(Aspergillus
nidulans)
PF07745
(Glyco_hydro_53)
4 TYR A 151
THR A 148
GLY A 140
LEU A 180
None
1.02A 4w5nA-4bf7A:
2.6
4w5nA-4bf7A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cot EXTRACELLULAR
ENDO-ALPHA-(1->5)-L-
ARABINANASE 2


(Bacillus
subtilis)
PF04616
(Glyco_hydro_43)
PF16369
(GH43_C)
4 TYR A 313
THR A 336
GLY A 317
LEU A 332
None
0.96A 4w5nA-4cotA:
undetectable
4w5nA-4cotA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e09 PLASMID PARTITIONING
PROTEIN PARF


(Escherichia
coli)
PF01656
(CbiA)
4 TYR A 172
THR A  17
GLY A  14
LEU A 136
ACP  A 301 (-3.9A)
ACP  A 301 (-3.4A)
ACP  A 301 (-3.2A)
None
1.49A 4w5nA-4e09A:
4.0
4w5nA-4e09A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmg VP1

(Human
polyomavirus 5)
PF00718
(Polyoma_coat)
4 TYR A  79
THR A  78
GLY A 304
LEU A 138
None
0.95A 4w5nA-4fmgA:
undetectable
4w5nA-4fmgA:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4laq SINGLE HEAVY CHAIN
VARIABLE FRAGMENT


(Mus musculus)
PF07686
(V-set)
4 TYR H  59
THR H  57
GLY H  49
LEU H  80
None
1.36A 4w5nA-4laqH:
undetectable
4w5nA-4laqH:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqo METHANOL
DEHYDROGENASE
PROTEIN, LARGE
SUBUNIT


(Methylococcus
capsulatus)
no annotation 4 TYR B 211
THR B 213
GLY B 200
LEU B 186
None
1.28A 4w5nA-4tqoB:
undetectable
4w5nA-4tqoB:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ut1 FLAGELLAR
HOOK-ASSOCIATED
PROTEIN


(Burkholderia
pseudomallei)
PF06429
(Flg_bbr_C)
4 TYR A 365
THR A 361
GLY A 401
LEU A 404
None
1.50A 4w5nA-4ut1A:
undetectable
4w5nA-4ut1A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1b ANTE

(Streptomyces
sp. NRRL 2288)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 TYR A  64
THR A 326
GLY A 324
LEU A 214
NAP  A 501 (-3.2A)
NAP  A 501 (-3.6A)
NAP  A 501 ( 3.3A)
NAP  A 501 (-3.8A)
1.16A 4w5nA-4y1bA:
undetectable
4w5nA-4y1bA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yue S4B6 FAB HEAVY CHAIN

(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 TYR H  63
THR H  61
GLY H  52
LEU H  84
None
1.43A 4w5nA-4yueH:
undetectable
4w5nA-4yueH:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9r OMEGA-3
POLYUNSATURATED
FATTY ACID SYNTHASE
SUBUNIT PFAD


(Shewanella
oneidensis)
PF03060
(NMO)
4 TYR A 104
THR A 334
GLY A 107
LEU A 118
None
None
FMN  A 602 (-3.2A)
None
1.31A 4w5nA-4z9rA:
undetectable
4w5nA-4z9rA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayu IG VH,ANTI-LYSOZYME

(Mus musculus)
PF07686
(V-set)
4 TYR H  59
THR H  57
GLY H  49
LEU H  80
None
1.33A 4w5nA-5ayuH:
undetectable
4w5nA-5ayuH:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2g ENDOLYSIN,CLAUDIN-4

(Homo sapiens;
Escherichia
virus T4)
PF00822
(PMP22_Claudin)
PF00959
(Phage_lysozyme)
4 TYR A1018
THR A1026
GLY A1028
LEU A1013
None
1.30A 4w5nA-5b2gA:
undetectable
4w5nA-5b2gA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0o COHESIN SUBUNIT
PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P


(Lachancea
thermotolerans)
no annotation 4 TYR A 268
THR A 301
GLY A 298
LEU A 322
None
1.39A 4w5nA-5f0oA:
undetectable
4w5nA-5f0oA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hkj COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
A,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
C,COMPLEMENT C1Q
SUBCOMPONENT SUBUNIT
B


(Homo sapiens)
PF00386
(C1q)
4 TYR A 326
THR A 328
GLY A 401
LEU A 267
None
1.29A 4w5nA-5hkjA:
undetectable
4w5nA-5hkjA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp6 EXTRACELLULAR
ARABINANASE


(Geobacillus
stearothermophilus)
PF04616
(Glyco_hydro_43)
PF13385
(Laminin_G_3)
PF16369
(GH43_C)
4 TYR A 390
THR A 413
GLY A 394
LEU A 409
None
0.96A 4w5nA-5hp6A:
undetectable
4w5nA-5hp6A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i92 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE


(Pseudomonas
aeruginosa)
PF00202
(Aminotran_3)
4 TYR A  55
THR A 403
GLY A 401
LEU A 357
None
None
EDO  A 502 (-3.7A)
EDO  A 502 (-3.8A)
1.18A 4w5nA-5i92A:
2.5
4w5nA-5i92A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijv BOVINE FAB E03 HEAVY
CHAIN


(Bos taurus)
no annotation 4 TYR H  59
THR H  57
GLY H  49
LEU H  80
None
1.12A 4w5nA-5ijvH:
undetectable
4w5nA-5ijvH:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8s AMINO ACYL PEPTIDASE

(Sporosarcina
psychrophila)
PF00326
(Peptidase_S9)
4 TYR A 171
THR A 157
GLY A 152
LEU A 148
None
1.48A 4w5nA-5l8sA:
4.2
4w5nA-5l8sA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sx4 PANITUMUMAB FAB
HEAVY CHAIN


(Homo sapiens)
no annotation 4 TYR J  61
THR J  59
GLY J  51
LEU J  82
None
1.34A 4w5nA-5sx4J:
undetectable
4w5nA-5sx4J:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjf ALLOPHYCOCYANIN
ALPHA SUBUNIT


(Gracilaria
chilensis)
PF00502
(Phycobilisome)
4 TYR A 116
THR A 121
GLY A 125
LEU A  85
CYC  A 201 (-4.6A)
CYC  A 201 (-3.7A)
CYC  A 201 (-3.0A)
CYC  A 201 ( 3.6A)
1.25A 4w5nA-5tjfA:
undetectable
4w5nA-5tjfA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tmh POLYPROTEIN

(Zika virus)
PF00972
(Flavi_NS5)
PF01728
(FtsJ)
4 TYR A 609
THR A 613
GLY A 507
LEU A 511
None
1.42A 4w5nA-5tmhA:
undetectable
4w5nA-5tmhA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens)
no annotation 4 TYR A 174
THR A 183
GLY A 201
LEU A 382
None
0.47A 4w5nA-5weaA:
60.4
4w5nA-5weaA:
undetectable